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Aliases for MIR103A1 Gene

Subcategory (RNA class) for MIR103A1 Gene

miRNA

Quality Score for this RNA gene is

14.2

Aliases for MIR103A1 Gene

  • MicroRNA 103a-1 2 3 5
  • MicroRNA 103-1 2 3
  • Hsa-Mir-103a-1 3
  • Hsa-Mir-103-1 3
  • Mir-103a-1 3
  • MIRN103-1 3
  • MIR103-1 3

External Ids for MIR103A1 Gene

Previous HGNC Symbols for MIR103A1 Gene

  • MIRN103-1
  • MIR103-1

Previous GeneCards Identifiers for MIR103A1 Gene

  • GC05M167988

Summaries for MIR103A1 Gene

Entrez Gene Summary for MIR103A1 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR103A1 Gene

MIR103A1 (MicroRNA 103a-1) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cardiomyocyte hypertrophy and MicroRNAs in cancer.

fRNAdb sequence ontologies for MIR103A1 Gene - the ORGUL cluster for this gene includes several descriptions:

  • miRNA: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

View fRNAdb secondary structures for MIR103A1

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR103A1 Gene

Genomics for MIR103A1 Gene

Regulatory Elements for MIR103A1 Gene

Enhancers for MIR103A1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05G168583 0.6 ENCODE 11.2 -23.6 -23592 1.6 TBL1XR1 SIN3A JUNB REST DPF2 RAD21 IKZF1 NFE2 ZNF652 SPI1 MIR103A1 RARS ENSG00000254192 FBLL1 PANK3 RPL10P9
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR103A1 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR103A1 Gene

Chromosome:
5
Start:
168,560,896 bp from pter
End:
168,560,973 bp from pter
Size:
78 bases
Orientation:
Minus strand

Genomic View for MIR103A1 Gene

Genes around MIR103A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR103A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR103A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR103A1 Gene

ORGUL Member Location for MIR103A1 Gene

ORGUL Member Location for MIR103A1 gene

Proteins for MIR103A1 Gene

Post-translational modifications for MIR103A1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR103A1 Gene

Domains & Families for MIR103A1 Gene

Gene Families for MIR103A1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR103A1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR103A1 Gene

Function for MIR103A1 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR103A1 Gene

Localization for MIR103A1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR103A1 Gene

Pathways & Interactions for MIR103A1 Gene

genes like me logo Genes that share pathways with MIR103A1: view

Pathways by source for MIR103A1 Gene

1 BioSystems pathway for MIR103A1 Gene
1 KEGG pathway for MIR103A1 Gene

Interacting Proteins for MIR103A1 Gene

Gene Ontology (GO) - Biological Process for MIR103A1 Gene

None

No data available for SIGNOR curated interactions for MIR103A1 Gene

Drugs & Compounds for MIR103A1 Gene

No Compound Related Data Available

Transcripts for MIR103A1 Gene

fRNAdb Secondary structures for MIR103A1 Gene

  • hsa-mir-103a-1_MI0000109_Homo_sapiens_miR-103a-1_stem-loop_hairpin
  • AF480545

mRNA/cDNA for MIR103A1 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR103A1 Gene

No ASD Table

Relevant External Links for MIR103A1 Gene

GeneLoc Exon Structure for
MIR103A1
ECgene alternative splicing isoforms for
MIR103A1

Expression for MIR103A1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR103A1 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR103A1 Gene:

MIR103A1
genes like me logo Genes that share expression patterns with MIR103A1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR103A1 Gene

Orthologs for MIR103A1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR103A1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia bta-mir-103-1 35
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir103-1 35
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-103-1 35
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-103-1 35
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-103-1 35
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-103-1 35
  • 96 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-103 35
  • 68 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-103 35
  • 72 (a)
ManyToMany
Species where no ortholog for MIR103A1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR103A1 Gene

ENSEMBL:
Gene Tree for MIR103A1 (if available)
TreeFam:
Gene Tree for MIR103A1 (if available)

Paralogs for MIR103A1 Gene

No data available for Paralogs for MIR103A1 Gene

Variants for MIR103A1 Gene

Sequence variations from dbSNP and Humsavar for MIR103A1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1002908307 -- 168,561,039(+) GAGCA(C/T)AGCTG intron-variant, downstream-variant-500B, upstream-variant-2KB
rs1003313499 -- 168,562,850(+) AGCAA(A/C)GGAGT intron-variant, upstream-variant-2KB
rs1003365809 -- 168,562,603(+) CAGAA(C/G)AGTAA intron-variant, upstream-variant-2KB
rs1003495276 -- 168,562,546(+) GGGGT(A/G)CACAA intron-variant, upstream-variant-2KB
rs1003963661 -- 168,562,182(+) AGAAG(C/T)GCTAA intron-variant, upstream-variant-2KB

Relevant External Links for MIR103A1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR103A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR103A1 Gene

Disorders for MIR103A1 Gene

Relevant External Links for MIR103A1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR103A1

No disorders were found for MIR103A1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR103A1 Gene

Publications for MIR103A1 Gene

  1. MicroRNA-103 suppresses tumor cell proliferation by targeting PDCD10 in prostate cancer. (PMID: 26771762) Fu X. … Wang H. (Prostate 2016) 3 64
  2. Plasma microRNA-103, microRNA-107, and microRNA-194 levels are not biomarkers for human diffuse gastric cancer. (PMID: 27909811) Oze I. … Yuasa Y. (J. Cancer Res. Clin. Oncol. 2016) 3 64
  3. microRNA-103a functions as a mechanosensitive microRNA to inhibit bone formation through targeting Runx2. (PMID: 25195535) Zuo B. … Chen X. (J. Bone Miner. Res. 2015) 3 64
  4. miR-103/107 modulates multidrug resistance in human gastric carcinoma by downregulating Cav-1. (PMID: 25407491) Zhang Y. … Liu Y. (Tumour Biol. 2015) 3 64
  5. miRNA-103: molecular link between insulin resistance and nonalcoholic fatty liver disease. (PMID: 25593466) Xu Q. … Yao M.X. (World J. Gastroenterol. 2015) 3 64

Products for MIR103A1 Gene

Sources for MIR103A1 Gene

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