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Aliases for MIR101-2 Gene

Subcategory (RNA class) for MIR101-2 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR101-2 Gene

  • MicroRNA 101-2 2 3 5
  • Hsa-Mir-101-2 3
  • Mir-101-2 3
  • MIRN101-2 3

External Ids for MIR101-2 Gene

Previous HGNC Symbols for MIR101-2 Gene

  • MIRN101-2

Previous GeneCards Identifiers for MIR101-2 Gene

  • GC09P004843
  • GC09P004852
  • GC09P004855
  • GC09P004854
  • GC09P004856
  • GC09P004857
  • GC09P004858
  • GC09P004859
  • GC09P004861
  • GC09P004862

Summaries for MIR101-2 Gene

Entrez Gene Summary for MIR101-2 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR101-2 Gene

MIR101-2 (MicroRNA 101-2) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer and Metastatic brain tumor.

Additional gene information for MIR101-2 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR101-2 Gene

Genomics for MIR101-2 Gene

GeneHancer (GH) Regulatory Elements for MIR101-2 Gene

Promoters and enhancers for MIR101-2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09I004848 Enhancer 1.2 Ensembl ENCODE dbSUPER 550.8 -0.1 -50 2.7 ELF3 SOX13 CTCF FOXA2 ZIC2 RAD21 RARA YY1 TEAD3 HNF4G ENSG00000228165 GC09P004850 GC09P004851 GC09P004853 MIR101-2 JAK2 RCL1 KLF4P1 GC09M004845
GH09I004851 Enhancer 0.3 ENCODE 550.8 +1.5 1499 0.2 TRIM28 GC09P004850 GC09P004851 GC09P004853 MIR101-2 ENSG00000228165 PIR61723 RCL1 GC09M004845
GH09I004983 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 10.5 +135.2 135224 3.8 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF207 ZNF143 JAK2 ENSG00000228165 MIR101-2 MTND6P5 MTCO1P11 CSNK1G2P1 GC09M004845
GH09I004791 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 10.9 -57.0 -56979 3.3 PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF2 ZNF213 ZNF207 ZNF143 FOS RCL1 RIC1 JAK2 PDSS1P1 ENSG00000228165 MIR101-2 KLF4P1 GC09P004780
GH09I004797 Enhancer 1.1 Ensembl ENCODE 10.9 -52.1 -52100 1.6 SMAD1 YY1 TCF12 GATA2 ZNF143 ATF7 NCOA1 ZNF592 MBD2 SMARCA4 MIR101-2 ENSG00000228165 JAK2 KLF4P1 RCL1 GC09P004780
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR101-2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR101-2 Gene

Genomic Locations for MIR101-2 Gene
chr9:4,850,297-4,850,375
(GRCh38/hg38)
Size:
79 bases
Orientation:
Plus strand
chr9:4,850,291-4,850,381
(GRCh37/hg19)

Genomic View for MIR101-2 Gene

Genes around MIR101-2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR101-2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR101-2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR101-2 Gene

Proteins for MIR101-2 Gene

Post-translational modifications for MIR101-2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR101-2 Gene

Domains & Families for MIR101-2 Gene

Gene Families for MIR101-2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR101-2: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR101-2 Gene

Function for MIR101-2 Gene

Phenotypes From GWAS Catalog for MIR101-2 Gene

Gene Ontology (GO) - Molecular Function for MIR101-2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 20829195
genes like me logo Genes that share ontologies with MIR101-2: view

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR101-2 Gene

Localization for MIR101-2 Gene

Gene Ontology (GO) - Cellular Components for MIR101-2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 26646931
genes like me logo Genes that share ontologies with MIR101-2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR101-2 Gene

Pathways & Interactions for MIR101-2 Gene

genes like me logo Genes that share pathways with MIR101-2: view

Pathways by source for MIR101-2 Gene

1 BioSystems pathway for MIR101-2 Gene
1 KEGG pathway for MIR101-2 Gene

Interacting Proteins for MIR101-2 Gene

Gene Ontology (GO) - Biological Process for MIR101-2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IDA 20829195
genes like me logo Genes that share ontologies with MIR101-2: view

No data available for SIGNOR curated interactions for MIR101-2 Gene

Drugs & Compounds for MIR101-2 Gene

No Compound Related Data Available

Transcripts for MIR101-2 Gene

mRNA/cDNA for MIR101-2 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR101-2 Gene

No ASD Table

Relevant External Links for MIR101-2 Gene

GeneLoc Exon Structure for
MIR101-2
ECgene alternative splicing isoforms for
MIR101-2

Expression for MIR101-2 Gene

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR101-2 Gene

Orthologs for MIR101-2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR101-2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia bta-mir-101-2 34
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-101-2 34
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-101-2 34
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-101-2 34
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-101-2 34 34
  • 97 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Mir101b 34
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-101-1 34
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-101-2 34
  • 98 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-101b 34
  • 64 (a)
OneToOne
Species where no ortholog for MIR101-2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR101-2 Gene

ENSEMBL:
Gene Tree for MIR101-2 (if available)
TreeFam:
Gene Tree for MIR101-2 (if available)

Paralogs for MIR101-2 Gene

No data available for Paralogs for MIR101-2 Gene

Variants for MIR101-2 Gene

Sequence variations from dbSNP and Humsavar for MIR101-2 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000101938 -- 4,849,946(+) A/G upstream_transcript_variant
rs1000154499 -- 4,849,757(+) G/A upstream_transcript_variant
rs1001109149 -- 4,849,041(+) G/A upstream_transcript_variant
rs1002233884 -- 4,848,628(+) C/G upstream_transcript_variant
rs1002324069 -- 4,849,077(+) T/G upstream_transcript_variant

Additional Variant Information for MIR101-2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR101-2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR101-2 Gene

Disorders for MIR101-2 Gene

Additional Disease Information for MIR101-2

No disorders were found for MIR101-2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR101-2 Gene

Publications for MIR101-2 Gene

  1. miR-101 Enhances Cisplatin-Induced DNA Damage Through Decreasing Nicotinamide Adenine Dinucleotide Phosphate Levels by Directly Repressing Tp53-Induced Glycolysis and Apoptosis Regulator Expression in Prostate Cancer Cells. (PMID: 28384067) Huang S … Wang S (DNA and cell biology 2017) 3 58
  2. The long non-coding RNA NEAT1 interacted with miR-101 modulates breast cancer growth by targeting EZH2. (PMID: 28034643) Qian K … Xu X (Archives of biochemistry and biophysics 2017) 3 58
  3. Association of MicroRNAs and YRNAs With Platelet Function. (PMID: 26646931) Kaudewitz D … Mayr M (Circulation research 2016) 3 58
  4. Vascular mimicry formation is promoted by paracrine TGF-β and SDF1 of cancer-associated fibroblasts and inhibited by miR-101 in hepatocellular carcinoma. (PMID: 27693460) Yang J … Zhuang SM (Cancer letters 2016) 3 58
  5. Long non-coding RNA XIST regulates gastric cancer progression by acting as a molecular sponge of miR-101 to modulate EZH2 expression. (PMID: 27620004) Chen DL … Xu RH (Journal of experimental & clinical cancer research : CR 2016) 3 58

Products for MIR101-2 Gene

Sources for MIR101-2 Gene

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