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Aliases for MIR101-2 Gene

Subcategory (RNA class) for MIR101-2 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR101-2 Gene

  • MicroRNA 101-2 2 3 5
  • Hsa-Mir-101-2 3
  • Mir-101-2 3
  • MIRN101-2 3

External Ids for MIR101-2 Gene

Previous HGNC Symbols for MIR101-2 Gene

  • MIRN101-2

Previous GeneCards Identifiers for MIR101-2 Gene

  • GC09P004843
  • GC09P004852
  • GC09P004855
  • GC09P004854
  • GC09P004856
  • GC09P004857
  • GC09P004858
  • GC09P004859

Summaries for MIR101-2 Gene

Entrez Gene Summary for MIR101-2 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR101-2 Gene

MIR101-2 (MicroRNA 101-2) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Metastatic brain tumor and MicroRNAs in cancer.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR101-2 Gene

Genomics for MIR101-2 Gene

Regulatory Elements for MIR101-2 Gene

Enhancers for MIR101-2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09G004983 1.3 ENCODE dbSUPER 10.5 +135.2 135224 3.8 HDGF PKNOX1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207 RIC1 ENSG00000228165 MIR101-2 AK4P4 MTND6P5 MTCO1P11 JAK2 CSNK1G2P1
GH09G004797 1.2 Ensembl ENCODE 10.9 -52.1 -52101 1.6 YY1 TCF12 GATA2 ZNF143 ZNF263 NCOA1 ZNF592 MBD2 SMARCA4 MYNN MIR101-2 ENSG00000228165 JAK2 KLF4P1 RCL1
GH09G004791 1.1 ENCODE 10.9 -57.0 -56979 3.3 PKNOX1 CREB3L1 MLX AGO1 ARID4B SIN3A DMAP1 ZNF2 ZNF143 ZNF207 RCL1 JAK2 MIR101-2 ENSG00000228165 KLF4P1
GH09G004815 1 Ensembl ENCODE 11.9 -34.7 -34741 0.9 TBL1XR1 EBF1 RELA ARID3A CBX5 POLR2A EED ETV6 RELB ZSCAN29 RCL1 ENSG00000228165 MIR101-2 JAK2 KLF4P1 GC09P004850
GH09G004987 1.1 ENCODE dbSUPER 10.5 +138.0 137956 1.5 HDAC1 HDGF CBX3 RB1 CREB3L1 ARNT NFRKB ARID4B ZNF2 RAD21 MIR101-2 ENSG00000228165 JAK2 CSNK1G2P1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR101-2 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR101-2 Gene

Chromosome:
9
Start:
4,850,297 bp from pter
End:
4,850,375 bp from pter
Size:
79 bases
Orientation:
Plus strand

Genomic View for MIR101-2 Gene

Genes around MIR101-2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR101-2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR101-2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR101-2 Gene

Proteins for MIR101-2 Gene

Post-translational modifications for MIR101-2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR101-2 Gene

Domains & Families for MIR101-2 Gene

Gene Families for MIR101-2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR101-2: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR101-2 Gene

Function for MIR101-2 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR101-2 Gene

Localization for MIR101-2 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR101-2 Gene

Pathways & Interactions for MIR101-2 Gene

genes like me logo Genes that share pathways with MIR101-2: view

Pathways by source for MIR101-2 Gene

1 BioSystems pathway for MIR101-2 Gene
1 KEGG pathway for MIR101-2 Gene

Interacting Proteins for MIR101-2 Gene

Gene Ontology (GO) - Biological Process for MIR101-2 Gene

None

No data available for SIGNOR curated interactions for MIR101-2 Gene

Drugs & Compounds for MIR101-2 Gene

No Compound Related Data Available

Transcripts for MIR101-2 Gene

mRNA/cDNA for MIR101-2 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR101-2 Gene

No ASD Table

Relevant External Links for MIR101-2 Gene

GeneLoc Exon Structure for
MIR101-2
ECgene alternative splicing isoforms for
MIR101-2

Expression for MIR101-2 Gene

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR101-2 Gene

Orthologs for MIR101-2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR101-2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia bta-mir-101-2 35
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-101-2 35
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-101-2 35
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-101-2 35
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-101-2 35 35
  • 97 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Mir101b 35
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-101-1 35
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-101-2 35
  • 98 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-101b 35
  • 64 (a)
OneToOne
Species where no ortholog for MIR101-2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR101-2 Gene

ENSEMBL:
Gene Tree for MIR101-2 (if available)
TreeFam:
Gene Tree for MIR101-2 (if available)

Paralogs for MIR101-2 Gene

No data available for Paralogs for MIR101-2 Gene

Variants for MIR101-2 Gene

Sequence variations from dbSNP and Humsavar for MIR101-2 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1000101938 -- 4,849,946(+) AGGAT(A/G)TGAGC intron-variant, upstream-variant-2KB
rs1000154499 -- 4,849,757(+) CCCAG(A/G)TAACT intron-variant, upstream-variant-2KB
rs1001109149 -- 4,849,041(+) TGAGC(A/G)TCATC intron-variant, upstream-variant-2KB
rs1002233884 -- 4,848,628(+) TTATT(C/G)CAGAA intron-variant, upstream-variant-2KB
rs1002324069 -- 4,849,077(+) CATCT(G/T)CTAGA intron-variant, upstream-variant-2KB

Relevant External Links for MIR101-2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR101-2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR101-2 Gene

Disorders for MIR101-2 Gene

Relevant External Links for MIR101-2

Human Genome Epidemiology (HuGE) Navigator
MIR101-2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR101-2

No disorders were found for MIR101-2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR101-2 Gene

Publications for MIR101-2 Gene

  1. miR-101 Enhances Cisplatin-Induced DNA Damage Through Decreasing Nicotinamide Adenine Dinucleotide Phosphate Levels by Directly Repressing Tp53-Induced Glycolysis and Apoptosis Regulator Expression in Prostate Cancer Cells. (PMID: 28384067) Huang S. … Wang S. (DNA Cell Biol. 2017) 3 64
  2. miR-101-2, miR-125b-2 and miR-451a act as potential tumor suppressors in gastric cancer through regulation of the PI3K/AKT/mTOR pathway. (PMID: 26458815) Riquelme I. … Roa J.C. (Cell Oncol (Dordr) 2016) 3 64
  3. MicroRNA-101 polymorphisms and risk of head and neck squamous cell carcinoma in a Chinese population. (PMID: 26490987) Miao L. … Chen N. (Tumour Biol. 2016) 3 64
  4. MicroRNA-101 targets von Hippel-Lindau tumor suppressor (VHL) to induce HIF1I+ mediated apoptosis and cell cycle arrest in normoxia condition. (PMID: 26841847) Liu N. … Gao J.X. (Sci Rep 2016) 3 64
  5. [miR-101 inhibits the proliferation and migration of breast cancer cells via downregulating the expression of DNA methyltransferase 3a]. (PMID: 26927545) Liu J. … Liu D. (Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2016) 3 64

Products for MIR101-2 Gene

Sources for MIR101-2 Gene

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