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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MIR100HG Gene

RNA gene   GIFtS: 24
GCID: GC11M121902

Mir-100-Let-7a-2 Cluster Host Gene (Non-Protein Coding)

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Subcategory (RNA class): lncRNA

Quality score for this RNA gene is 9

Aliases
Mir-100-Let-7a-2 Cluster Host Gene (Non-Protein Coding)1 2
Adipogenesis Down-Regulated Transcript 11
AGD12

External Ids:    HGNC: 395221   Entrez Gene: 3999592   Ensembl: ENSG000002552487   
ORGUL members:    fRNAdb10:FR058175      
H-InvDB12:HIT000191978    
NCBI13:L09269    
NONCODE14:n372791 n372790 n372884 n381785 n372886 see all 14      
RNAdb15:HIV1678    

Export aliases for MIR100HG gene to outside databases

Previous GC identifer: GC11M121961


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for MIR100HG Gene: 
MIR100HG (mir-100-let-7a-2 cluster host gene (non-protein coding)) is an RNA gene, and is affiliated with the lncRNA class. Diseases associated with MIR100HG include myopia.

fRNAdb sequence ontology for MIR100HG:
ncRNA - An RNA transcript that does not encode for a protein rather the RNA molecule is the gene product.

View fRNAdb secondary structures for MIR100HG

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_033899.8  NC_018922.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for MIR100HG
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for MIR100HG

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MIR100HG


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q24.1   Ensembl cytogenetic band:  11q24.1   HGNC cytogenetic band: 11q24.1

MIR100HG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MIR100HG gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M121902:  view genomic region     (about GC identifiers)

Start:
121,899,063 bp from pter      End:
122,073,770 bp from pter
Size:
174,708 bases      Orientation:
minus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for MIR100HG

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB: --


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
LNCRNA: Long non-coding RNAs

  --

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Animal Models:
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MIR100HG

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
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Browse Tocris compounds for MIR100HG

Search CenterWatch for drugs/clinical trials and news about MIR100HG

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section
1 fRNAdb Secondary structure:


Unigene Clusters for MIR100HG:

Mir-100-let-7a-2 cluster host gene (non-protein coding)
Hs.44098  [show with all ESTs], Hs.732590  [show with all ESTs]
Unigene Representative Sequences: AK123947, AB075498
14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000530955(sense_overlapping) ENST00000532319(sense_overlapping) ENST00000531470(sense_overlapping) ENST00000531381(sense_overlapping) ENST00000529823(sense_overlapping)
ENST00000524376(sense_overlapping) ENST00000528986(sense_overlapping) ENST00000531071(sense_overlapping) ENST00000534195(sense_overlapping) ENST00000532890(sense_overlapping)
ENST00000532315(sense_overlapping) ENST00000534297(sense_overlapping) ENST00000530072(sense_overlapping) ENST00000531629(sense_overlapping)
miRNA
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Additional mRNA sequence: 

AB075498.1 AK091713.1 AK311309.1 AL832469.1 BC040599.1 BX538058.1 NR_024430.1 

23 DOTS entries:

DT.95089767  DT.211601  DT.95264897  DT.92053401  DT.120737828  DT.97842184  DT.100752275  DT.120737783 
DT.120737767  DT.95264898  DT.97842182  DT.120737786  DT.120737871  DT.40243724  DT.40315345  DT.101964246 
DT.120737703  DT.120737776  DT.120737860  DT.120737867  DT.75143417  DT.91979339  DT.97800803 

24/139 AceView cDNA sequences (see all 139):

BF060946 BI753385 BM462594 CA396628 BQ959997 CA396990 BM966955 AU117663 
CA418008 BM672072 BX538058 AA887671 BM460512 AA613964 AU118519 AA401861 
BX381192 AW169201 AI027125 BM893692 BQ021459 AA428694 BM541657 AI783770 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

Expression evidence for MIR100HG:H-invDB

MIR100HG expression in normal human tissues (normalized intensities)      MIR100HG embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: ATAATTGTTG
MIR100HG Expression
About this image


MIR100HG expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/1 selected tissues (see all 1) fully expand
 
 Endothelium (Cardiovascular System)
         CD31, CD144 positive cells ( Two-step protocol for endothelial differentiation by...

Genevestigator expression for MIR100HG

SOURCE GeneReport for Unigene clusters: Hs.44098 Hs.732590
    SABiosciences Custom PCR Arrays for MIR100HG
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In Situ
Assay Products:
 

 
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section
  --

ENSEMBL Gene Tree for MIR100HG (if available)
TreeFam Gene Tree for MIR100HG (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/1909 SNPs in MIR100HG are shown (see all 1909)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 11 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs557122791,2
C--117968567(+) ACACA-/CACA/C
ACACACACA
TCTTA
1 -- int11NA 2
rs1868196641,2
--121842106(+) TCTTGC/TATGGA 1 -- int10--------
rs171260981,2
C,F,H--121842120(+) TTGTGA/CAGATT 1 -- int19Minor allele frequency- C:0.01NA NS EA WA 682
rs1491214001,2
--121842175(+) AGAGGC/TCTTCT 1 -- int10--------
rs171261011,2
C,F--121842230(+) CAGAAT/CGGGAG 1 -- int14Minor allele frequency- C:0.04NA 258
rs1431811881,2
--121842240(+) GAAATA/GGAGAA 1 -- int10--------
rs1930025141,2
--121842338(+) CTACCC/TGACAG 1 -- int10--------
rs1482605041,2
--121842454(+) GGGAGA/GAGCAG 1 -- int10--------
rs346521551,2
F--121842506(+) GCTGGC/ACCACA 1 -- int11Minor allele frequency- A:0.50NA 4
rs1158009811,2
C,F--121842543(+) TCTCTC/TTCACA 1 -- int11Minor allele frequency- T:0.02WA 118

HapMap Linkage Disequilibrium report for MIR100HG (121899063 - 122073770 bp)

Structural Variations
     Database of Genomic Variants (DGV) 4 variations for MIR100HG:    About this table     
Variant IDTypeSubtypePubMed ID
esv274332CNV Insertion20981092
nsv898430CNV Gain21882294
dgv17n68CNV Gain17160897
esv275465CNV Gain+Loss21479260

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM information: 194071 604499 607967 609270 609470    
2 diseases for MIR100HG:    About MalaCards
myopia    


MIR100HG for disorders           About GeneDecksing


Export disorders for MIR100HG gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for MIR100HG gene integrated from 9 sources:
(articles sorted by number of sources associating them with MIR100HG)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Evaluation of BLID and LOC399959 as candidate genes f or high myopia in the Chinese Han population. (PubMed id 21031016)1, 3 Zhao F....Zhou X. (2010)
  2. Transcripts of unknown function in multiple-signaling pathways involved in human stem cell differentiation. (PubMed id 19531736)1, 3 Kikuchi K.... Aizawa Y. (2009)
  3. A genome-wide association analysis identified a novel susceptible locus for pathological myopia at 11q24.1. (PubMed id 19779542)1 Nakanishi H....Matsuda F. (2009)
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
  6. (PubMed id 15103394)10 
  7. (PubMed id 18089548)10 
  8. (PubMed id 15608161)10 

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 399959 HGNC: 39522 AceView: LOC399959 Ensembl:ENSG00000255248 euGenes: HUgn399959
ECgene: MIR100HG H-InvDB: MIR100HG

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
  --

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for MIR100HG gene:
Search GeneIP for patents involving MIR100HG

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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