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Aliases for MIR100 Gene

Subcategory (RNA class) for MIR100 Gene

miRNA

Quality Score for this RNA gene is

13.2

Aliases for MIR100 Gene

  • MicroRNA 100 2 3
  • MIRN100 3 6
  • Hsa-Mir-100 3
  • MiR-100 3

External Ids for MIR100 Gene

Previous HGNC Symbols for MIR100 Gene

  • MIRN100

Previous GeneCards Identifiers for MIR100 Gene

  • GC11M121531
  • GC11M122023
  • GC11M122027
  • GC11M122030
  • GC11M122033

Summaries for MIR100 Gene

Entrez Gene Summary for MIR100 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR100 Gene

MIR100 (MicroRNA 100) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR100 include esophageal cancer. Among its related pathways are MicroRNAs in cancer and miRNAs involved in DDR.

fRNAdb sequence ontologies for MIR100 Gene

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

View fRNAdb secondary structures for MIR100

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR100 Gene

Genomics for MIR100 Gene

Genomic Location for MIR100 Gene

Start:
122,152,229 bp from pter
End:
122,152,308 bp from pter
Size:
80 bases
Orientation:
Minus strand

Genomic View for MIR100 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR100 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR100 Gene

ORGUL Member Location for MIR100 Gene

ORGUL Member Location for MIR100 gene

No data available for Regulatory Elements for MIR100 Gene

Proteins for MIR100 Gene

Post-translational modifications for MIR100 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR100 Gene

Domains for MIR100 Gene

Gene Families for MIR100 Gene

HGNC:
  • MIR :ncRNAs / Micro RNAs

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR100: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR100 Gene

Function for MIR100 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MIR100 Gene

Localization for MIR100 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR100 Gene

Pathways for MIR100 Gene

genes like me logo Genes that share pathways with MIR100: view

Pathways by source for MIR100 Gene

1 BioSystems pathway for MIR100 Gene
1 KEGG pathway for MIR100 Gene

Interacting Proteins for MIR100 Gene

Gene Ontology (GO) - Biological Process for MIR100 Gene

None

Transcripts for MIR100 Gene

fRNAdb Secondary structures for MIR100 Gene

  • hsa-miR-100-5p_MIMAT0000098_Homo_sapiens_miR-100-5p_mature

mRNA/cDNA for MIR100 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR100 Gene

No ASD Table

Relevant External Links for MIR100 Gene

GeneLoc Exon Structure for
MIR100
ECgene alternative splicing isoforms for
MIR100

Expression for MIR100 Gene

mRNA expression in normal human tissues for MIR100 Gene

genes like me logo Genes that share expressions with MIR100: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for MIR100 Gene

Orthologs for MIR100 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR100 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia bta-mir-100 36
  • 93 (a)
ManyToMany
bta-mir-10a 36
  • 45 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia cfa-mir-10a 36
  • 54 (a)
ManyToMany
cfa-mir-99a-2 36
  • 88 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-100 36
  • 93 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Mir100 36
  • 90 (a)
ManyToMany
Mir10a 36
  • 45 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-100 36
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-10a 36
  • 57 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia aca-mir-10a 36
  • 42 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii dre-mir-100-1 36
  • 73 (a)
ManyToMany
dre-mir-10a 36
  • 45 (a)
ManyToMany
mir100-2 36
  • 84 (a)
ManyToMany
Species with no ortholog for MIR100:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR100 Gene

ENSEMBL:
Gene Tree for MIR100 (if available)
TreeFam:
Gene Tree for MIR100 (if available)

Paralogs for MIR100 Gene

No data available for Paralogs for MIR100 Gene

Variants for MIR100 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR100 Gene

Variant ID Type Subtype PubMed ID
dgv17n68 CNV Gain 17160897
nsv898430 CNV Gain 21882294

Relevant External Links for MIR100 Gene

HapMap Linkage Disequilibrium report
MIR100

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for MIR100 Gene

Disorders for MIR100 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for MIR100 Gene in MalaCards »

(1) Diseases for MIR100 Gene including...

Relevant External Links for MIR100

Genetic Association Database (GAD)
MIR100
Human Genome Epidemiology (HuGE) Navigator
MIR100
genes like me logo Genes that share disorders with MIR100: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for MIR100 Gene

Publications for MIR100 Gene

  1. Genetic variations in microRNA-related genes are associated with survival and recurrence in patients with renal cell carcinoma. (PMID: 20732906) Lin J. … Wu X. (Carcinogenesis 2010) 3 48
  2. Genetic variation in MicroRNA genes and risk of oral premalignant lesions. (PMID: 19851984) Clague J. … Wu X. (Mol. Carcinog. 2010) 3 48
  3. Genetic variations in microRNA-related genes are novel susceptibility loci for esophageal cancer risk. (PMID: 19138993) Ye Y. … Wu X. (Cancer Prev Res (Phila) 2008) 3 48
  4. Change in expression of miR-let7c, miR-100, and miR-218 from high grade localized prostate cancer to metastasis. (PMID: 19372056) Leite K.R. … Srougi M. (Urol. Oncol. 2011) 3
  5. Significance of Plk1 regulation by miR-100 in human nasopharyngeal cancer. (PMID: 19739117) Shi W. … Liu F.F. (Int. J. Cancer 2010) 3

Products for MIR100 Gene

Sources for MIR100 Gene

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