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Aliases for MIR100 Gene

Subcategory (RNA class) for MIR100 Gene

miRNA

Quality Score for this RNA gene is

13.2

Aliases for MIR100 Gene

  • MicroRNA 100 2 3 5
  • Hsa-Mir-100 3
  • MiR-100 3
  • MIRN100 3

External Ids for MIR100 Gene

Previous HGNC Symbols for MIR100 Gene

  • MIRN100

Previous GeneCards Identifiers for MIR100 Gene

  • GC11M121531
  • GC11M122023
  • GC11M122027
  • GC11M122030
  • GC11M122033

Summaries for MIR100 Gene

Entrez Gene Summary for MIR100 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR100 Gene

MIR100 (MicroRNA 100) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are miRNAs involved in DNA damage response and MicroRNAs in cancer.

fRNAdb sequence ontologies for MIR100 Gene

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

View fRNAdb secondary structures for MIR100

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR100 Gene

Genomics for MIR100 Gene

Regulatory Elements for MIR100 Gene

Enhancers for MIR100 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G122153 1.2 Ensembl ENCODE dbSUPER 0.4 -10.2 -10220 18.5 CTCF JUN ZSCAN4 RAD21 POLR2A FOS MAFK TCF7L2 BHLHE40 CHD1 BLID MIR100HG ENSG00000255015 UBASH3B GC11M122154 GC11M122156 MIR100 GC11P122184
GH11G122174 1.6 FANTOM5 Ensembl ENCODE dbSUPER 0.3 -26.5 -26486 8.4 TAF1 SIN3A ZNF316 GATA2 POLR2A SCRT2 FOS NFE2 MAFK TCF7L2 BLID MIR100HG ENSG00000255219 GC11P122184 GC11M122154 MIR100 GC11M122156
GH11G122172 0.8 Ensembl ENCODE dbSUPER 0.3 -20.8 -20831 1.6 BLID MIR100HG GC11P122184 GC11M122156 GC11M122154 MIR100
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR100 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR100 Gene

Chromosome:
11
Start:
122,152,229 bp from pter
End:
122,152,308 bp from pter
Size:
80 bases
Orientation:
Minus strand

Genomic View for MIR100 Gene

Genes around MIR100 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR100 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR100 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR100 Gene

ORGUL Member Location for MIR100 Gene

ORGUL Member Location for MIR100 gene

Proteins for MIR100 Gene

Post-translational modifications for MIR100 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR100 Gene

Domains & Families for MIR100 Gene

Gene Families for MIR100 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR100: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR100 Gene

Function for MIR100 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR100 Gene

Localization for MIR100 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR100 Gene

Pathways & Interactions for MIR100 Gene

genes like me logo Genes that share pathways with MIR100: view

Pathways by source for MIR100 Gene

1 BioSystems pathway for MIR100 Gene
1 KEGG pathway for MIR100 Gene

Interacting Proteins for MIR100 Gene

Gene Ontology (GO) - Biological Process for MIR100 Gene

None

No data available for SIGNOR curated interactions for MIR100 Gene

Drugs & Compounds for MIR100 Gene

No Compound Related Data Available

Transcripts for MIR100 Gene

fRNAdb Secondary structures for MIR100 Gene

  • hsa-miR-100-5p_MIMAT0000098_Homo_sapiens_miR-100-5p_mature

mRNA/cDNA for MIR100 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR100 Gene

No ASD Table

Relevant External Links for MIR100 Gene

GeneLoc Exon Structure for
MIR100
ECgene alternative splicing isoforms for
MIR100

Expression for MIR100 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR100 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR100 Gene:

MIR100
genes like me logo Genes that share expression patterns with MIR100: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR100 Gene

Orthologs for MIR100 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR100 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-100 35
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-100 35
  • 93 (a)
ManyToMany
bta-mir-10a 35
  • 45 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-100 35
  • 93 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Mir100 35
  • 90 (a)
ManyToMany
Mir10a 35
  • 45 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia cfa-mir-99a-2 35
  • 88 (a)
ManyToMany
cfa-mir-10a 35
  • 54 (a)
ManyToMany
chicken
(Gallus gallus)
Aves gga-mir-10a 35
  • 57 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia aca-mir-10a 35
  • 42 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii mir100-2 35
  • 84 (a)
ManyToMany
dre-mir-100-1 35
  • 73 (a)
ManyToMany
dre-mir-10a 35
  • 45 (a)
ManyToMany
Species where no ortholog for MIR100 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR100 Gene

ENSEMBL:
Gene Tree for MIR100 (if available)
TreeFam:
Gene Tree for MIR100 (if available)

Paralogs for MIR100 Gene

No data available for Paralogs for MIR100 Gene

Variants for MIR100 Gene

Sequence variations from dbSNP and Humsavar for MIR100 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000145703 -- 122,152,421(+) GAAAG(A/G)ACTTC intron-variant, upstream-variant-2KB
rs1000408935 -- 122,152,670(+) AACAC(-/AT)GAGAG intron-variant, upstream-variant-2KB
rs1000477387 -- 122,153,768(+) GGGGA(A/T)CAAAA intron-variant, upstream-variant-2KB
rs1002966616 -- 122,153,140(+) TACAT(A/G)TAAGA intron-variant, upstream-variant-2KB
rs1003067767 -- 122,153,403(+) CACTC(C/G)TTTCT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR100 Gene

Variant ID Type Subtype PubMed ID
dgv17n68 CNV gain 17160897

Relevant External Links for MIR100 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR100

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR100 Gene

Disorders for MIR100 Gene

Relevant External Links for MIR100

Genetic Association Database (GAD)
MIR100
Human Genome Epidemiology (HuGE) Navigator
MIR100
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR100

No disorders were found for MIR100 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR100 Gene

Publications for MIR100 Gene

  1. Genetic variation in MicroRNA genes and risk of oral premalignant lesions. (PMID: 19851984) Clague J. … Wu X. (Mol. Carcinog. 2010) 3 46 64
  2. Genetic variations in microRNA-related genes are associated with survival and recurrence in patients with renal cell carcinoma. (PMID: 20732906) Lin J. … Wu X. (Carcinogenesis 2010) 3 46 64
  3. Genetic variations in microRNA-related genes are novel susceptibility loci for esophageal cancer risk. (PMID: 19138993) Ye Y. … Wu X. (Cancer Prev Res (Phila) 2008) 3 46 64
  4. Downregulation of microRNA-100/microRNA-125b is associated with lymph node metastasis in early colorectal cancer with submucosal invasion. (PMID: 28032929) Fujino Y. … Takayama T. (Cancer Sci. 2017) 3 64
  5. Evaluation of miR-182/miR-100 Ratio for Diagnosis and Survival Prediction in Bladder Cancer. (PMID: 27631180) Chen Z. … Shi L. (Arch Iran Med 2016) 3 64

Products for MIR100 Gene

Sources for MIR100 Gene

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