Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MIR1-2 Gene

Subcategory (RNA class) for MIR1-2 Gene


Quality Score for this RNA gene is


Aliases for MIR1-2 Gene

  • MicroRNA 1-2 2 3
  • Hsa-Mir-1-2 3
  • MiRNA1-2 3
  • MIRN1-2 3

External Ids for MIR1-2 Gene

Previous HGNC Symbols for MIR1-2 Gene

  • MIRN1-2

Previous GeneCards Identifiers for MIR1-2 Gene

  • GC18M017667
  • GC18M019408

Summaries for MIR1-2 Gene

Entrez Gene Summary for MIR1-2 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR1-2 Gene

MIR1-2 (MicroRNA 1-2) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer and TFs Regulate miRNAs related to cardiac hypertrophy.

fRNAdb sequence ontologies for MIR1-2 Gene - the ORGUL cluster for this gene includes several descriptions:

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR1-2

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR1-2 Gene

Genomics for MIR1-2 Gene

Genomic Location for MIR1-2 Gene

21,828,996 bp from pter
21,829,106 bp from pter
111 bases
Minus strand

Genomic View for MIR1-2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR1-2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR1-2 Gene

ORGUL Member Location for MIR1-2 Gene

ORGUL Member Location for MIR1-2 gene

No data available for Regulatory Elements for MIR1-2 Gene

Proteins for MIR1-2 Gene

Post-translational modifications for MIR1-2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR1-2 Gene

Domains for MIR1-2 Gene

Gene Families for MIR1-2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR1-2: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR1-2 Gene

Function for MIR1-2 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MIR1-2 Gene

Localization for MIR1-2 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR1-2 Gene

Pathways for MIR1-2 Gene

genes like me logo Genes that share pathways with MIR1-2: view

Pathways by source for MIR1-2 Gene

1 BioSystems pathway for MIR1-2 Gene
1 KEGG pathway for MIR1-2 Gene

Interacting Proteins for MIR1-2 Gene

Gene Ontology (GO) - Biological Process for MIR1-2 Gene


Transcripts for MIR1-2 Gene

fRNAdb Secondary structures for MIR1-2 Gene

  • hsa-miR-1_MIMAT0000416_Homo_sapiens_miR-1_mature
  • FR084914
  • hsa-mir-1-2_MI0000437_Homo_sapiens_miR-1-2_stem-loop_hairpin

mRNA/cDNA for MIR1-2 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR1-2 Gene

No ASD Table

Relevant External Links for MIR1-2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR1-2 Gene

mRNA differential expression in normal tissues according to GTEx for MIR1-2 Gene

This gene is overexpressed in Muscle - Skeletal (27.9), Heart - Atrial Appendage (13.0), and Heart - Left Ventricle (5.7).

Primer Products

In Situ Assay Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for MIR1-2 Gene

Orthologs for MIR1-2 Gene

Evolution for MIR1-2 Gene

Gene Tree for MIR1-2 (if available)
Gene Tree for MIR1-2 (if available)

No data available for Orthologs for MIR1-2 Gene

Paralogs for MIR1-2 Gene

No data available for Paralogs for MIR1-2 Gene

Variants for MIR1-2 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR1-2 Gene

Variant ID Type Subtype PubMed ID
nsv909450 CNV Gain 21882294
nsv2222 CNV Insertion 18451855
dgv3395n71 CNV Loss 21882294
nsv909453 CNV Loss 21882294

Relevant External Links for MIR1-2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for MIR1-2 Gene

Disorders for MIR1-2 Gene

Relevant External Links for MIR1-2

Human Genome Epidemiology (HuGE) Navigator

No disorders were found for MIR1-2 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for MIR1-2 Gene

Publications for MIR1-2 Gene

  1. Identification of tissue-specific microRNAs from mouse. (PMID: 12007417) Lagos-Quintana M. … Tuschl T. (Curr. Biol. 2002) 3
  2. Serum response factor regulates a muscle-specific microRNA that targets Hand2 during cardiogenesis. (PMID: 15951802) Zhao Y. … Srivastava D. (Nature 2005) 3
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3
  4. A mammalian microRNA expression atlas based on small RNA library sequencing. (PMID: 17604727) Landgraf P. … Tuschl T. (Cell 2007) 3
  5. Analysis of deep sequencing microRNA expression profile from human embryonic stem cells derived mesenchymal stem cells reveals possible role of let-7 microRNA family in downstream targeting of hepatic nuclear factor 4 alpha. (PMID: 20158877) Koh W. … Tanavde V. (BMC Genomics 2010) 3

Products for MIR1-2 Gene

Sources for MIR1-2 Gene

Back to Top