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Aliases for MIR1-2 Gene

Subcategory (RNA class) for MIR1-2 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR1-2 Gene

  • MicroRNA 1-2 2 3
  • MIR133A1 Host Gene 5
  • Hsa-Mir-1-2 3
  • MIR133A1HG 5
  • MiRNA1-2 3
  • Mir-1-2 3
  • MIRN1-2 3

External Ids for MIR1-2 Gene

Previous HGNC Symbols for MIR1-2 Gene

  • MIRN1-2

Previous GeneCards Identifiers for MIR1-2 Gene

  • GC18M017667
  • GC18M019408

Summaries for MIR1-2 Gene

Entrez Gene Summary for MIR1-2 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR1-2 Gene

MIR1-2 (MicroRNA 1-2) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are TFs Regulate miRNAs related to cardiac hypertrophy and MicroRNAs in cancer.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR1-2 Gene

Genomics for MIR1-2 Gene

Regulatory Elements for MIR1-2 Gene

Enhancers for MIR1-2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around MIR1-2 on UCSC Golden Path with GeneCards custom track

Promoters for MIR1-2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for MIR1-2 Gene

Chromosome:
18
Start:
21,825,487 bp from pter
End:
21,831,410 bp from pter
Size:
5,924 bases
Orientation:
Minus strand

Genomic View for MIR1-2 Gene

Genes around MIR1-2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR1-2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR1-2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR1-2 Gene

ORGUL Member Location for MIR1-2 Gene

ORGUL Member Location for MIR1-2 gene

Proteins for MIR1-2 Gene

Post-translational modifications for MIR1-2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR1-2 Gene

Domains & Families for MIR1-2 Gene

Gene Families for MIR1-2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR1-2: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR1-2 Gene

Function for MIR1-2 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR1-2 Gene

Localization for MIR1-2 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR1-2 Gene

Pathways & Interactions for MIR1-2 Gene

genes like me logo Genes that share pathways with MIR1-2: view

Pathways by source for MIR1-2 Gene

1 BioSystems pathway for MIR1-2 Gene
1 KEGG pathway for MIR1-2 Gene

Interacting Proteins for MIR1-2 Gene

Gene Ontology (GO) - Biological Process for MIR1-2 Gene

None

No data available for SIGNOR curated interactions for MIR1-2 Gene

Drugs & Compounds for MIR1-2 Gene

No Compound Related Data Available

Transcripts for MIR1-2 Gene

mRNA/cDNA for MIR1-2 Gene

(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR1-2 Gene

No ASD Table

Relevant External Links for MIR1-2 Gene

GeneLoc Exon Structure for
MIR1-2
ECgene alternative splicing isoforms for
MIR1-2

Expression for MIR1-2 Gene

mRNA differential expression in normal tissues according to GTEx for MIR1-2 Gene

This gene is overexpressed in Muscle - Skeletal (x27.9), Heart - Atrial Appendage (x13.0), and Heart - Left Ventricle (x5.7).

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR1-2 Gene

Orthologs for MIR1-2 Gene

Evolution for MIR1-2 Gene

ENSEMBL:
Gene Tree for MIR1-2 (if available)
TreeFam:
Gene Tree for MIR1-2 (if available)

No data available for Orthologs for MIR1-2 Gene

Paralogs for MIR1-2 Gene

No data available for Paralogs for MIR1-2 Gene

Variants for MIR1-2 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR1-2 Gene

Variant ID Type Subtype PubMed ID
nsv2222 CNV insertion 18451855

Relevant External Links for MIR1-2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR1-2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Variation tolerance for MIR1-2 Gene

Disorders for MIR1-2 Gene

Relevant External Links for MIR1-2

Human Genome Epidemiology (HuGE) Navigator
MIR1-2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR1-2

No disorders were found for MIR1-2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR1-2 Gene

Publications for MIR1-2 Gene

  1. MALAT1 induced migration and invasion of human breast cancer cells by competitively binding miR-1 with cdc42. (PMID: 26926567) Chou J. … Xi T. (Biochem. Biophys. Res. Commun. 2016) 3 65
  2. Effect of microRNA-1 on hepatocellular carcinoma tumor endothelial cells. (PMID: 26019452) Hu C. … Li W. (World J. Gastroenterol. 2015) 3 65
  3. The potential value of miR-1 and miR-374b as biomarkers for colorectal cancer. (PMID: 26045793) Wu X. … Xu Y. (Int J Clin Exp Pathol 2015) 3 65
  4. MicroRNA Stability in Postmortem FFPE Tissues: Quantitative Analysis Using Autoptic Samples from Acute Myocardial Infarction Patients. (PMID: 26046358) Kakimoto Y. … Osawa M. (PLoS ONE 2015) 3 65
  5. Abnormal expression of miR-1 in breast carcinoma as a potent prognostic factor. (PMID: 26331797) Minemura H. … Suzuki T. (Cancer Sci. 2015) 3 65

Products for MIR1-2 Gene

Sources for MIR1-2 Gene

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