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Aliases for MIR1-2 Gene

Subcategory (RNA class) for MIR1-2 Gene


Quality Score for this RNA gene is


Aliases for MIR1-2 Gene

  • MicroRNA 1-2 2 3 5
  • Hsa-Mir-1-2 3
  • MiRNA1-2 3
  • Mir-1-2 3
  • MIRN1-2 3

External Ids for MIR1-2 Gene

Previous HGNC Symbols for MIR1-2 Gene

  • MIRN1-2

Previous GeneCards Identifiers for MIR1-2 Gene

  • GC18M017667
  • GC18M019408

Summaries for MIR1-2 Gene

Entrez Gene Summary for MIR1-2 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR1-2 Gene

MIR1-2 (MicroRNA 1-2) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer and TarBasePathway.

fRNAdb sequence ontologies for MIR1-2 Gene - the ORGUL cluster for this gene includes several descriptions:

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR1-2

Additional gene information for MIR1-2 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR1-2 Gene

Genomics for MIR1-2 Gene

Regulatory Elements for MIR1-2 Gene

Enhancers for MIR1-2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH18H021852 0.8 Ensembl ENCODE 11.4 -24.0 -23998 1.1 HDGF PKNOX1 RUNX3 SPI1 RFX5 ENSG00000199977 MIR1-2 MIR133A1 MIR320C1 RPL34P32 MIR133A1HG
GH18H021825 0.6 ENCODE 0.7 -0.4 -437 7.9 MAFF ZNF316 MAFG HNF4A MLLT1 EMSY MAFK MIB1 MIR320C1 MIR133A1HG ABHD3 MIR1-2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR1-2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR1-2 Gene

Genomic Locations for MIR1-2 Gene
85 bases
Minus strand

Genomic View for MIR1-2 Gene

Genes around MIR1-2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR1-2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR1-2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR1-2 Gene

ORGUL Member Location for MIR1-2 Gene

ORGUL Member Location for MIR1-2 gene

Proteins for MIR1-2 Gene

Post-translational modifications for MIR1-2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR1-2 Gene

Domains & Families for MIR1-2 Gene

Gene Families for MIR1-2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR1-2: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR1-2 Gene

Function for MIR1-2 Gene

Gene Ontology (GO) - Molecular Function for MIR1-2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 17397913
genes like me logo Genes that share ontologies with MIR1-2: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR1-2 Gene

Localization for MIR1-2 Gene

Gene Ontology (GO) - Cellular Components for MIR1-2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 20159880
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with MIR1-2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR1-2 Gene

Pathways & Interactions for MIR1-2 Gene

SuperPathways for MIR1-2 Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
2 TarBasePathway
genes like me logo Genes that share pathways with MIR1-2: view

Pathways by source for MIR1-2 Gene

1 BioSystems pathway for MIR1-2 Gene
1 KEGG pathway for MIR1-2 Gene

Interacting Proteins for MIR1-2 Gene

Gene Ontology (GO) - Biological Process for MIR1-2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001934 positive regulation of protein phosphorylation IDA 19131648
GO:0010455 positive regulation of cell fate commitment ISS --
GO:0010460 positive regulation of heart rate ISS --
GO:0010614 negative regulation of cardiac muscle hypertrophy ISS --
GO:0010831 positive regulation of myotube differentiation ISS --
genes like me logo Genes that share ontologies with MIR1-2: view

No data available for SIGNOR curated interactions for MIR1-2 Gene

Drugs & Compounds for MIR1-2 Gene

No Compound Related Data Available

Transcripts for MIR1-2 Gene

fRNAdb Secondary structures for MIR1-2 Gene

  • FR309639
  • hsa-mir-1-2_MI0000437_Homo_sapiens_miR-1-2_stem-loop_hairpin

mRNA/cDNA for MIR1-2 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR1-2 Gene

No ASD Table

Relevant External Links for MIR1-2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR1-2 Gene

mRNA differential expression in normal tissues according to GTEx for MIR1-2 Gene

This gene is overexpressed in Muscle - Skeletal (x27.9), Heart - Atrial Appendage (x13.0), and Heart - Left Ventricle (x5.7).

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR1-2 Gene

Orthologs for MIR1-2 Gene

Evolution for MIR1-2 Gene

Gene Tree for MIR1-2 (if available)
Gene Tree for MIR1-2 (if available)

No data available for Orthologs for MIR1-2 Gene

Paralogs for MIR1-2 Gene

No data available for Paralogs for MIR1-2 Gene

Variants for MIR1-2 Gene

Sequence variations from dbSNP and Humsavar for MIR1-2 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs1002876525 -- 21,830,061(+) GCAGG(A/G)ATAGT intron-variant, upstream-variant-2KB
rs1003659130 -- 21,829,848(+) TAAAG(A/G)ATAAC intron-variant, upstream-variant-2KB
rs1003759963 -- 21,830,284(+) TAGAA(A/G)CTAAT intron-variant, upstream-variant-2KB
rs1005936609 -- 21,830,901(+) AACCA(A/C)CAACA intron-variant, upstream-variant-2KB
rs1006071649 -- 21,831,017(+) ACAAA(-/G)GCCAA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR1-2 Gene

Variant ID Type Subtype PubMed ID
nsv2222 CNV insertion 18451855

Relevant External Links for MIR1-2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR1-2 Gene

Disorders for MIR1-2 Gene

Relevant External Links for MIR1-2

Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MIR1-2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR1-2 Gene

Publications for MIR1-2 Gene

  1. Identification of tissue-specific microRNAs from mouse. (PMID: 12007417) Lagos-Quintana M … Tuschl T (Current biology : CB 2002) 1 3 60
  2. Analysis of Circulating miR-1, miR-23a, and miR-26a in Atrial Fibrillation Patients Undergoing Coronary Bypass Artery Grafting Surgery. (PMID: 28422282) Feldman A … Farsky P (Annals of human genetics 2017) 3 60
  3. The role of MALAT1/miR-1/slug axis on radioresistance in nasopharyngeal carcinoma. (PMID: 26482776) Jin C … Ma L (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016) 3 60
  4. The regulatory function of microRNA-1 in arrhythmias. (PMID: 26671473) Liao C … Xu D (Molecular bioSystems 2016) 3 60
  5. Differential microRNA expression profiling of mesothelioma and expression analysis of miR-1 and miR-214 in mesothelioma. (PMID: 26820394) Amatya VJ … Takeshima Y (International journal of oncology 2016) 3 60

Products for MIR1-2 Gene

Sources for MIR1-2 Gene

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