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Aliases for MIR1-1 Gene

Subcategory (RNA class) for MIR1-1 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR1-1 Gene

  • MicroRNA 1-1 2 3
  • Hsa-Mir-1-1 3
  • MiRNA1-1 3
  • MIRN1-1 3

External Ids for MIR1-1 Gene

ORGUL Members for MIR1-1 Gene

Previous HGNC Symbols for MIR1-1 Gene

  • MIRN1-1

Previous GeneCards Identifiers for MIR1-1 Gene

  • GC20P060563
  • GC20P061153
  • GC20P061156
  • GC20P061159

Summaries for MIR1-1 Gene

Entrez Gene Summary for MIR1-1 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR1-1 Gene

MIR1-1 (MicroRNA 1-1) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Heart Development and MicroRNAs in cancer.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR1-1 Gene

Genomics for MIR1-1 Gene

Genomic Location for MIR1-1 Gene

Start:
62,554,303 bp from pter
End:
62,554,379 bp from pter
Size:
77 bases
Orientation:
Plus strand

Genomic View for MIR1-1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR1-1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR1-1 Gene

No data available for Regulatory Elements for MIR1-1 Gene

Proteins for MIR1-1 Gene

Post-translational modifications for MIR1-1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR1-1 Gene

Domains for MIR1-1 Gene

Gene Families for MIR1-1 Gene

HGNC:
  • MIR :ncRNAs / Micro RNAs

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR1-1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR1-1 Gene

Function for MIR1-1 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MIR1-1 Gene

Localization for MIR1-1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR1-1 Gene

Pathways for MIR1-1 Gene

genes like me logo Genes that share pathways with MIR1-1: view

Pathways by source for MIR1-1 Gene

Interacting Proteins for MIR1-1 Gene

Gene Ontology (GO) - Biological Process for MIR1-1 Gene

None

Transcripts for MIR1-1 Gene

mRNA/cDNA for MIR1-1 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR1-1 Gene

No ASD Table

Relevant External Links for MIR1-1 Gene

GeneLoc Exon Structure for
MIR1-1
ECgene alternative splicing isoforms for
MIR1-1

Expression for MIR1-1 Gene

mRNA expression in normal human tissues for MIR1-1 Gene

genes like me logo Genes that share expressions with MIR1-1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for MIR1-1 Gene

Orthologs for MIR1-1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR1-1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-1-1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-1-1 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-1-1 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir1a-1 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-1-2 36
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-1a-1 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-1a-2 36
  • 70 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii mir1-1 36
  • 63 (a)
OneToOne
Species with no ortholog for MIR1-1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR1-1 Gene

ENSEMBL:
Gene Tree for MIR1-1 (if available)
TreeFam:
Gene Tree for MIR1-1 (if available)

Paralogs for MIR1-1 Gene

No data available for Paralogs for MIR1-1 Gene

Variants for MIR1-1 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR1-1 Gene

Variant ID Type Subtype PubMed ID
nsv913047 CNV Loss 21882294
esv2422398 CNV Duplication 17116639
nsv470556 CNV Loss 18288195
dgv4603n71 CNV Loss 21882294
nsv459065 CNV Gain 19166990
nsv913073 CNV Loss 21882294
dgv4608n71 CNV Loss 21882294
dgv4610n71 CNV Loss 21882294
nsv459068 CNV Gain 19166990
essv22589 CNV CNV 17122850
nsv913101 CNV Loss 21882294
nsv913103 CNV Loss 21882294

Relevant External Links for MIR1-1 Gene

HapMap Linkage Disequilibrium report
MIR1-1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for MIR1-1 Gene

Disorders for MIR1-1 Gene

No disorders were found for MIR1-1 Gene.

No data available for UniProtKB/Swiss-Prot for MIR1-1 Gene

Publications for MIR1-1 Gene

  1. Identification of tissue-specific microRNAs from mouse. (PMID: 12007417) Lagos-Quintana M. … Tuschl T. (Curr. Biol. 2002) 3
  2. Serum response factor regulates a muscle-specific microRNA that targets Hand2 during cardiogenesis. (PMID: 15951802) Zhao Y. … Srivastava D. (Nature 2005) 3
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3
  4. A mammalian microRNA expression atlas based on small RNA library sequencing. (PMID: 17604727) Landgraf P. … Tuschl T. (Cell 2007) 3
  5. MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure. (PMID: 17606841) Thum T. … Bauersachs J. (Circulation 2007) 3

Products for MIR1-1 Gene

Sources for MIR1-1 Gene

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