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MIPOL1 Gene

protein-coding   GIFtS: 49
GCID: GC14P037667

Mirror-Image Polydactyly 1

  See MIPOL1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Mirror-Image Polydactyly 11 2
Mirror-Image Polydactyly Gene 1 Protein2

External Ids:    HGNC: 214601   Entrez Gene: 1452822   Ensembl: ENSG000001513387   OMIM: 6068505   UniProtKB: Q8TD103   

Export aliases for MIPOL1 gene to outside databases

Previous GC identifers: GC14P035069 GC14P031546 GC14P035657 GC14P036736 GC14P017781


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MIPOL1 Gene:
This gene encodes a coiled-coil domain-containing protein. The encoded protein may function as a tumor suppressor.
A translocation that results in truncation of the protein encoded by this locus has been associated with
mirror-image polydactyly, also known as Laurin-Sandrow Syndrome. Alternatively spliced transcript variants have
been described. (provided by RefSeq, Sep 2010)

GeneCards Summary for MIPOL1 Gene:
MIPOL1 (mirror-image polydactyly 1) is a protein-coding gene. Diseases associated with MIPOL1 include mirror-image polydactyly, and laurin-sandrow syndrome.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000014.9  NT_026437.13  NC_018925.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MIPOL1 gene promoter:
         AP-1   ATF-2   E47   CBF-B   CBF-A   Hand1   c-Jun   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMIPOL1 promoter sequence
   Search Chromatin IP Primers for MIPOL1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MIPOL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q13.3   Ensembl cytogenetic band:  14q13.3   HGNC cytogenetic band: 14q13.3

MIPOL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MIPOL1 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P037667:  view genomic region     (about GC identifiers)

Start:
37,667,118 bp from pter      End:
38,021,566 bp from pter
Size:
354,449 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MIPO1_HUMAN, Q8TD10 (See protein sequence)
Recommended Name: Mirror-image polydactyly gene 1 protein  
Size: 442 amino acids; 51537 Da
Secondary accessions: D3DSA4 Q7Z3J0 Q8IV14
Alternative splicing: 3 isoforms:  Q8TD10-1   Q8TD10-2   Q8TD10-3   (May be due to a competing acceptor splice site. No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MIPOL1: NX_Q8TD10

Explore proteomics data for MIPOL1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MIPOL1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001182225.1  NP_001182226.1  NP_620059.1  

    ENSEMBL proteins: 
     ENSP00000451297   ENSP00000333539   ENSP00000438319   ENSP00000450479   ENSP00000452478  
     ENSP00000450575   ENSP00000379589   ENSP00000444254   ENSP00000442529   ENSP00000437891  

    MIPOL1 Human Recombinant Protein Products:

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    Novus Biologicals MIPOL1 Proteins
    Novus Biologicals MIPOL1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MIPOL1

     
    Search eBioscience for Proteins for MIPOL1 

    MIPOL1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Abcam antibodies for MIPOL1
    Cloud-Clone Corp. Antibodies for MIPOL1
    Search ThermoFisher Antibodies for MIPOL1
    LSBio Antibodies in human, mouse, rat for MIPOL1

    MIPOL1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for MIPOL1
    Cloud-Clone Corp. CLIAs for MIPOL1
    Search eBioscience for ELISAs for MIPOL1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR026175 MIPOL1

    Graphical View of Domain Structure for InterPro Entry Q8TD10

    ProtoNet protein and cluster: Q8TD10


    Find genes that share domains with MIPOL1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MIPOL1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MIPOL1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MIPOL1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MIPOL1

    miRNA
    Products:
        
    miRTarBase miRNAs that target MIPOL1:
    hsa-mir-215-5p (MIRT024688), hsa-mir-192-5p (MIRT026684), hsa-let-7a-3p (MIRT039001)

    Block miRNA regulation of human, mouse, rat MIPOL1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MIPOL1 (see all 67):
    hsa-miR-140-5p hsa-miR-576-3p hsa-miR-15a hsa-miR-128 hsa-miR-3613-3p hsa-miR-761 hsa-miR-1 hsa-miR-466
    SwitchGear 3'UTR luciferase reporter plasmids (see all 2): MIPOL1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MIPOL1
    Predesigned siRNA for gene silencing in human, mouse, rat MIPOL1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MIPOL1

    Clone
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    OriGene clones in human, mouse for MIPOL1 (see all 7)
    OriGene ORF clones in mouse, rat for MIPOL1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): MIPOL1 (NM_001195296)
    Sino Biological Human cDNA Clone for MIPOL1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MIPOL1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MIPOL1

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for MIPOL1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MIPOL1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    cytoskeleton1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA19667180

    Find genes that share ontologies with MIPOL1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MIPOL1
    Interactions:

        Search GeneGlobe Interaction Network for MIPOL1

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for MIPOL1 (ENSP000003335394) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MIPOL1 (MIPO1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MIPOL1 gene (3 alternative transcripts): 
    NM_001195296.1  NM_001195297.1  NM_138731.6  

    Unigene Cluster for MIPOL1:

    Mirror-image polydactyly 1
    Hs.660396  [show with all ESTs]
    Unigene Representative Sequence: BX647795
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000556615 ENST00000327441(uc001wud.3 uc010ams.3 uc001wuc.3 uc001wue.3 uc010amt.3)
    ENST00000554930 ENST00000539062 ENST00000556451(uc001wub.4) ENST00000555870(uc010amr.2)
    ENST00000556753 ENST00000554114 ENST00000539174 ENST00000553349 ENST00000556940
    ENST00000396294 ENST00000537471 ENST00000545536 ENST00000536774
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MIPOL1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MIPOL1 (see all 67):
    hsa-miR-140-5p hsa-miR-576-3p hsa-miR-15a hsa-miR-128 hsa-miR-3613-3p hsa-miR-761 hsa-miR-1 hsa-miR-466
    SwitchGear 3'UTR luciferase reporter plasmids (see all 2): MIPOL1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MIPOL1
    Predesigned siRNA for gene silencing in human, mouse, rat MIPOL1
    Clone
    Products:
         
    OriGene clones in human, mouse for MIPOL1 (see all 7)
    OriGene ORF clones in mouse, rat for MIPOL1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): MIPOL1 (NM_001195296)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MIPOL1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MIPOL1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for MIPOL1
    OriGene qSTAR qPCR primer pairs in human, mouse for MIPOL1
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat MIPOL1
      QuantiTect SYBR Green Assays in human, mouse, rat MIPOL1
      QuantiFast Probe-based Assays in human, mouse, rat MIPOL1

    Additional mRNA sequence: 

    AK291850.1 AY059470.1 BC035870.1 BC036124.1 BC036523.1 BX537396.1 BX537870.1 BX647795.1 
    FJ423747.1 

    7 DOTS entries:

    DT.75131896  DT.40237807  DT.101983778  DT.101983779  DT.40263711  DT.97833436  DT.91675093 

    Selected AceView cDNA sequences (see all 43):

    BG190320 CK823627 AW008456 CA425382 BC036124 BQ129264 BC035870 BG291923 
    BX647795 BX509916 BX537396 BQ220174 AA565460 CB105473 AA012815 BX537870 
    BX490083 AI250034 BQ129413 BG204575 NM_138731 BX503675 BI964772 BP340598 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for MIPOL1    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b
    SP1:                                                  -                                         -               
    SP2:              -     -                             -                                                         
    SP3:              -                                   -                                         -               
    SP4:                                                                                                            


    ECgene alternative splicing isoforms for MIPOL1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MIPOL1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    MIPOL1 Expression
    About this image

    MIPOL1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MIPOL1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.660396

    UniProtKB/Swiss-Prot: MIPO1_HUMAN, Q8TD10
    Tissue specificity: Expressed very weakly in heart, liver, skeletal muscle, kidney, pancreas and fetal kidney. Not
    detected in brain, placenta and lung

        Custom PCR Arrays for MIPOL1
    Primer
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    QuantiTect SYBR Green Assays in human, mouse, rat MIPOL1
    QuantiFast Probe-based Assays in human, mouse, rat MIPOL1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MIPOL1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for MIPOL1 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mipol11 , 5 mirror-image polydactyly gene 1 homolog (human)1, 5 82.45(n)1
    76.46(a)1
      12 (24.70 cM)5
    734901  NM_001164370.11  NP_001157842.11 
     572304275 
    chicken
    (Gallus gallus)
    Aves MIPOL11 mirror-image polydactyly 1 72.84(n)
    65.12(a)
      423331  XM_004941766.1  XP_004941823.1 
    lizard
    (Anolis carolinensis)
    Reptilia MIPOL16
    mirror-image polydactyly 1
    52(a)
    1 ↔ 1
    1(25315006-25494906)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia mipol11 mirror-image polydactyly 1 61.16(n)
    53.33(a)
      100379932  XM_002935336.2  XP_002935382.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mipol11 mirror-image polydactyly 1 54.69(n)
    49.7(a)
      321390  XM_002665149.3  XP_002665195.3 


    ENSEMBL Gene Tree for MIPOL1 (if available)
    TreeFam Gene Tree for MIPOL1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MIPOL1 (see all 6535)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs340093521,2
    C--17780914(+) AAAAAA/-AAAAA 3 -- us2k11Minor allele frequency- -:0.00NA 2
    rs764539541,2
    C--17784392(+) TGTGTA/GTGTAT 3 -- int10--------
    rs584897981,2
    C--17893320(+) TCTCTATCT/-  
            
    GTTTT
    3 -- int11Minor allele frequency- -:0.00NA 2
    rs30619421,2
    C--17899727(+) TTTTT-/T/TTT 
            
    CCTTT
    6 -- int1 cds1 trp31NA 2
    rs344246201,2
    C--17913836(+) TTTTT-/T/T   
       T
    /TTT
    GCAAC
    6 -- int1 cds11NA 2
    rs714499881,2
    C--17916676(+) GAAATATATA/
            
    ATATG
    3 -- int11Minor allele frequency- -:0.50NA 2
    rs80222801,2
    C,A,H--17947280(+) GAACTA/GGGTAC 3 -- int113Minor allele frequency- G:0.01NA WA CSA EA 376
    rs106065541,2
    C--17950313(+) ATTGC-/AGAGTTT 3 -- int10--------
    rs113560721,2
    C--17956020(+) TTTTTA/TAAAAA 3 -- int10--------
    rs2014107541,2
    C--17986535(+) GGTTTC/TTAGCT 3 -- int10--------

    HapMap Linkage Disequilibrium report for MIPOL1 (37667118 - 37917118 bp, first 250kb of MIPOL1)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for MIPOL1 (see all 14):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv821405CNV Deletion20802225
    esv2632367CNV Insertion19546169
    esv273044CNV Insertion20981092
    esv268493CNV Insertion20981092
    nsv901640CNV Loss21882294
    nsv901641CNV Loss21882294
    nsv901638CNV Loss21882294
    dgv1876n71CNV Loss21882294
    nsv901639CNV Loss21882294
    esv2617029CNV Loss19546169

    Human Gene Mutation Database (HGMD): MIPOL1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MIPOL1
    DNA2.0 Custom Variant and Variant Library Synthesis for MIPOL1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606850   
    OMIM disorders: 135750  
    UniProtKB/Swiss-Prot: MIPO1_HUMAN, Q8TD10
  • Note=A chromosomal aberration involving MIPOL1 is found in a patient with mirror-image polydactyly of
    hands and feet without other anomalies (MIP). Translocation t(2;14)(p23.3;q13). MIP is a very rare congenital
    anomaly characterized by mirror-image duplication of digits. MIP is occasionally associated with dimelia of the
    ulna and fibula, tibial and/or fibular hypoplasia, nasal abnormality and other malformations. Most MIP cases are
    sporadic, but very rare parent-child transmissions observed in familial cases suggest an autosomal mode of
    inheritance

  • 3 diseases for MIPOL1:    
    About MalaCards
    mirror-image polydactyly    laurin-sandrow syndrome    polydactyly


    Find genes that share disorders with MIPOL1           About GenesLikeMe

    Genetic Association Database (GAD): MIPOL1
    Human Genome Epidemiology (HuGE) Navigator: MIPOL1 (1 document)

    Export disorders for MIPOL1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MIPOL1 gene, integrated from 10 sources (see all 11):
    (articles sorted by number of sources associating them with MIPOL1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel gene is disrupted at a 14q13 breakpoint of t(2;14) in a patient with mirror-image polydactyly of hands and feet. (PubMed id 11954550)1, 2, 3, 9 Kondoh S.... Yoshiura K. (J. Hum. Genet. 2002)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Chromosome 14 transfer and functional studies identify a candidate tumor suppressor gene, mirror image polydactyly 1, in nasopharyngeal carcinoma. (PubMed id 19667180)1, 3 Cheung A.K....Lung M.L. (Proc. Natl. Acad. Sci. U.S.A. 2009)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Rearrangement in the PITX2 and MIPOL1 genes in a patient with a t(4;14) chromosome. (PubMed id 12700605)1, 9 Kamnasaran D....Cox D.W. (Eur. J. Hum. Genet. 2003)
    6. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PubMed id 24255178)1 Couzens A.L....Gingras A.C. (Sci Signal 2013)
    7. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    8. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    9. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    10. Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (PubMed id 16712791)1 Wang A.G....Kim N.S. (Biochem. Biophys. Res. Commun. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 145282 HGNC: 21460 AceView: MIPOL1 Ensembl:ENSG00000151338 euGenes: HUgn145282
    ECgene: MIPOL1 H-InvDB: MIPOL1

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MIPOL1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    Patent Information for MIPOL1 gene:
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