MIPOL1 Gene
protein-coding GIFtS: 45
GCID: GC14P037667
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mirror-image polydactyly 1
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Aliases
for MIPOL1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Mirror-Image Polydactyly 11 2 | | Mirror-Image Polydactyly Gene 1 Protein2 |
Export aliases for MIPOL1 gene to outside databasesPrevious GC identifers: GC14P035069 GC14P031546 GC14P035657 GC14P036736 GC14P017781 |
Summaries
for MIPOL1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MIPOL1:
This gene encodes a coiled-coil domain-containing protein. The encoded protein may function as a tumor suppressor. Atranslocation that results in truncation of the protein encoded by this locus has been associated with mirror-imagepolydactyly, also known as Laurin-Sandrow Syndrome. Alternatively spliced transcript variants have been described.(provided by RefSeq, Sep 2010)
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Genomic Views
for MIPOL1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000014.8 NC_018925.1 NT_026437.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MIPOL1 gene promoter:
AP-1 ATF-2 E47 CBF-B CBF-A Hand1 c-Jun CBF(2)
Other transcription factors
Search SABiosciences Chromatin IP Primers for MIPOL1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MIPOL1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 14q13.3 Ensembl cytogenetic band: 14q13.3 HGNC cytogenetic band: 14q13.3MIPOL1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 14 GeneLoc Exon Structure GeneLoc location for GC14P037667: view genomic region
(about GC identifiers)
Start:
|
37,667,118 bp from pter |
End:
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38,021,566 bp from pter |
Size:
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354,449 bases |
Orientation:
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plus strand |
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Proteins
for MIPOL1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MIPO1_HUMAN, Q8TD10 (See
protein sequence)Recommended Name: Mirror-image polydactyly gene 1 protein Size: 442 amino acids; 51537 Da
Secondary accessions: D3DSA4 Q7Z3J0 Q8IV14Alternative splicing: 3 isoforms: Q8TD10-1 Q8TD10-2 Q8TD10-3 (May be due to a competing acceptor splice site. No experimental confirmation available)Explore the universe of human proteins at neXtProt for MIPOL1: NX_Q8TD10
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8TD10
MIPOL1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001182225.1 NP_001182226.1 NP_620059.1
ENSEMBL proteins: ENSP00000451297 ENSP00000333539 ENSP00000438319 ENSP00000450479 ENSP00000452478 ENSP00000450575 ENSP00000379589 ENSP00000444254 ENSP00000442529 ENSP00000437891
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table
MIPOL1 for ontologies About GeneDecksing
MIPOL1 Antibody Products:
Assay Products for MIPOL1: |
Protein
Domains /
Families
for MIPOL1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MIPOL1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8TD10ProtoNet protein and cluster: Q8TD10 |
Function
for MIPOL1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MIPOL1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MIPOL1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for MIPOL1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MIPOL1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MIPOL1 |
|
Pathways & Interactions
for MIPOL1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MIPOL1
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for MIPOL1 (ENSP000003335394) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for MIPOL1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MIPOL1
Search CenterWatch for drugs/clinical trials and news about MIPOL1 / MIPO1
|
Transcripts
for MIPOL1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MIPOL1 gene (3 alternative transcripts): NM_001195296.1 NM_001195297.1 NM_138731.6 Unigene Cluster for MIPOL1: Mirror-image polydactyly 1 Hs.660396 [show with all ESTs]Unigene Representative Sequence: BX64779516 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000556615 ENST00000327441(uc001wud.3 uc010ams.3 uc001wuc.3 uc001wue.3 uc010amt.3)
ENST00000554930 ENST00000539062 ENST00000556451(uc001wub.4) ENST00000555870(uc010amr.2)
ENST00000556753 ENST00000554114 ENST00000539174 ENST00000553349 ENST00000556940
ENST00000553562 ENST00000396294 ENST00000537471 ENST00000545536 ENST00000536774
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MIPOL1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MIPOL1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): MIPOL1 (NM_001195296) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MIPOL1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MIPOL1 |
Additional cDNA sequence: AK291850.1 AY059470.1 BC035870.1 BC036124.1 BC036523.1 BX537396.1 BX537870.1 BX647795.1 FJ423747.1 7 DOTS entries: DT.75131896 DT.40237807 DT.101983778 DT.101983779 DT.40263711 DT.97833436 DT.91675093 24/43 AceView cDNA sequences (see all 43): BG190320 CA425382 AW008456 BC035870 BQ129264 BC036124 CK823627 AI492095 CB105473 BP340598 AI806326 BI964772 AI250034 NM_138731 BC036523 BG204575 BI561546 BG718644 BG291923 BU181684 BX490083 BQ129413 BI917134 AA012815
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for MIPOL1 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b |
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| SP1: | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | - | | | | | | |
| SP2: | | | | | - | | - | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | - | | | | | | | | | | | | - | | | | | | | | | | | | | | - | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for MIPOL1
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Expression
for MIPOL1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MIPOL1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See MIPOL1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MIPOL1
SOURCE GeneReport for Unigene cluster: Hs.660396
UniProtKB/Swiss-Prot: MIPO1_HUMAN, Q8TD10Tissue specificity: Expressed very weakly in heart, liver, skeletal muscle, kidney, pancreas and fetal kidney. Notdetected in brain, placenta and lung
SABiosciences Custom PCR Arrays for MIPOL1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MIPOL1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat MIPOL1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MIPOL1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MIPOL1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MIPOL1 |
Orthologs
for MIPOL1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for MIPOL1 gene from 4/12 species (see all 12) About this table
ENSEMBL Gene Tree for MIPOL1 (if available)
TreeFam Gene Tree for MIPOL1 (if available) |
Paralogs
for MIPOL1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for MIPOL1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 14 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MIPOL1 (37667118 - 37917118 bp, first 250kb of MIPOL1)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for MIPOL1
2 CNVs: 66623 101927
4 Indels: 101928 76631 71888 87185
Human Gene Mutation Database (HGMD): MIPOL1
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MIPOL1 |
|
Disorders
/ Diseases
for MIPOL1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MIPOL1 for disorders About GeneDecksing
OMIM gene information: 606850
OMIM disorders: 135750
UniProtKB/Swiss-Prot: MIPO1_HUMAN, Q8TD10
Note=A chromosomal aberration involving MIPOL1 is found in a patient with mirror-image polydactyly of handsand feet without other anomalies (MIP). Translocation t(2;14)(p23.3;q13). MIP is a very rare congenital anomalycharacterized by mirror-image duplication of digits. MIP is occasionally associated with dimelia of the ulna andfibula, tibial and/or fibular hypoplasia, nasal abnormality and other malformations. Most MIP cases are sporadic, butvery rare parent-child transmissions observed in familial cases suggest an autosomal mode of inheritance
9  diseases for MIPOL1: About MalaCardsmirror-image polydactyly polydactyly laurin-sandrow syndrome adult astrocytic tumour
fibular hypoplasia intrahepatic cholangiocarcinoma cholangiocarcinoma nasopharyngitis
carcinoma
Human Genome Epidemiology (HuGE) Navigator: MIPOL1 (1 document)
Export disorders for MIPOL1 gene to outside databases
|
Publications
for MIPOL1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MIPOL1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with MIPOL1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A novel gene is disrupted at a 14q13 breakpoint of t(2;14) in a patient with mirror-image polydactyly of hands and feet. (PubMed id 11954550)1, 2, 3, 9 Kondoh S.... Yoshiura K. (2002)
- Chromosome 14 transfer and functional studies identif y a candidate tumor suppressor gene, mirror image polydactyly 1, in nasopharyng eal carcinoma. (PubMed id 19667180)1, 3 Cheung A.K....Lung M.L. (2009)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Rearrangement in the PITX2 and MIPOL1 genes in a patient with a t(4;14) chromosome. (PubMed id 12700605)1, 9 Kamnasaran D....Cox D.W. (2003)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (PubMed id 16712791)1 Wang A.G....Kim N.S. (2006)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for MIPOL1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MIPOL1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MIPOL1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MIPOL1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MIPOL1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for MIPOL1 gene:
Search GeneIP for patents involving MIPOL1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MIPOL1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for MIPOL1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MIPOL1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MIPOL1 | | | OriGene Protein Over-expression Lysate for MIPOL1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MIPOL1 | | OriGene 3'-UTR Clone for MIPOL1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MIPOL1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MIPOL1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for MIPOL1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MIPOL1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MIPOL1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MIPOL1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MIPOL1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MIPOL1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MIPOL1 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MIPOL1 |
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