Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MIPOL1 Gene

Aliases for MIPOL1 Gene

  • Mirror-Image Polydactyly 1 2 3

External Ids for MIPOL1 Gene

Summaries for MIPOL1 Gene

Entrez Gene Summary for MIPOL1 Gene

  • This gene encodes a coiled-coil domain-containing protein. The encoded protein may function as a tumor suppressor. A translocation that results in truncation of the protein encoded by this locus has been associated with mirror-image polydactyly, also known as Laurin-Sandrow Syndrome. Alternatively spliced transcript variants have been described. [provided by RefSeq, Sep 2010]

GeneCards Summary for MIPOL1 Gene

MIPOL1 (Mirror-Image Polydactyly 1) is a Protein Coding gene. Diseases associated with MIPOL1 include polydactyly and laurin-sandrow syndrome.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIPOL1 Gene

Genomics for MIPOL1 Gene

Genomic Location for MIPOL1 Gene

Start:
37,197,913 bp from pter
End:
37,552,361 bp from pter
Size:
354,449 bases
Orientation:
Plus strand

Genomic View for MIPOL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIPOL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIPOL1 Gene

Regulatory Elements for MIPOL1 Gene

Proteins for MIPOL1 Gene

  • Protein details for MIPOL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TD10-MIPO1_HUMAN
    Recommended name:
    Mirror-image polydactyly gene 1 protein
    Protein Accession:
    Q8TD10
    Secondary Accessions:
    • D3DSA4
    • Q7Z3J0
    • Q8IV14

    Protein attributes for MIPOL1 Gene

    Size:
    442 amino acids
    Molecular mass:
    51537 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MIPOL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MIPOL1 Gene

Proteomics data for MIPOL1 Gene at MOPED

Post-translational modifications for MIPOL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MIPOL1 Gene

Domains for MIPOL1 Gene

Protein Domains for MIPOL1 Gene

InterPro:
ProtoNet:
genes like me logo Genes that share domains with MIPOL1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for MIPOL1 Gene

Function for MIPOL1 Gene

Gene Ontology (GO) - Molecular Function for MIPOL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with MIPOL1: view

miRNA for MIPOL1 Gene

miRTarBase miRNAs that target MIPOL1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for MIPOL1 Gene

Localization for MIPOL1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MIPOL1 Gene COMPARTMENTS Subcellular localization image for MIPOL1 gene
Compartment Confidence
nucleus 5
cytosol 3
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for MIPOL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 19667180
genes like me logo Genes that share ontologies with MIPOL1: view

Pathways for MIPOL1 Gene

SuperPathways for MIPOL1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIPOL1 Gene

None

No data available for Pathways by source for MIPOL1 Gene

Transcripts for MIPOL1 Gene

Unigene Clusters for MIPOL1 Gene

Mirror-image polydactyly 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MIPOL1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b
SP1: - -
SP2: - - -
SP3: - - -
SP4:

Relevant External Links for MIPOL1 Gene

GeneLoc Exon Structure for
MIPOL1
ECgene alternative splicing isoforms for
MIPOL1

Expression for MIPOL1 Gene

mRNA expression in normal human tissues for MIPOL1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MIPOL1 Gene

SOURCE GeneReport for Unigene cluster for MIPOL1 Gene Hs.660396

mRNA Expression by UniProt/SwissProt for MIPOL1 Gene

Q8TD10-MIPO1_HUMAN
Tissue specificity: Expressed very weakly in heart, liver, skeletal muscle, kidney, pancreas and fetal kidney. Not detected in brain, placenta and lung.
genes like me logo Genes that share expressions with MIPOL1: view

Orthologs for MIPOL1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIPOL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MIPOL1 36
  • 99.7 (n)
  • 99.55 (a)
MIPOL1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MIPOL1 36
  • 89.97 (n)
  • 85.49 (a)
MIPOL1 37
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MIPOL1 36
  • 90.01 (n)
  • 85.13 (a)
MIPOL1 37
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mipol1 36
  • 82.45 (n)
  • 76.46 (a)
Mipol1 16
Mipol1 37
  • 74 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MIPOL1 37
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 65 (a)
OneToMany
-- 37
  • 54 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Mipol1 36
  • 83.17 (n)
  • 77.14 (a)
chicken
(Gallus gallus)
Aves MIPOL1 36
  • 72.84 (n)
  • 65.12 (a)
MIPOL1 37
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MIPOL1 37
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mipol1 36
  • 61.16 (n)
  • 53.33 (a)
zebrafish
(Danio rerio)
Actinopterygii mipol1 36
  • 54.69 (n)
  • 49.7 (a)
mipol1 37
  • 30 (a)
OneToOne
Species with no ortholog for MIPOL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIPOL1 Gene

ENSEMBL:
Gene Tree for MIPOL1 (if available)
TreeFam:
Gene Tree for MIPOL1 (if available)

Paralogs for MIPOL1 Gene

No data available for Paralogs for MIPOL1 Gene

Variants for MIPOL1 Gene

Sequence variations from dbSNP and Humsavar for MIPOL1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs714229 -- 37,242,535(-) TTATA(C/T)CATAA intron-variant
rs714230 -- 37,242,728(-) TCTCC(C/T)CCATC intron-variant
rs719135 -- 37,369,009(-) CAAAG(A/G)GTGCC intron-variant
rs719136 -- 37,368,620(-) CCATT(A/C)CTTAA intron-variant
rs743077 -- 37,290,302(-) GTTGT(A/G)GTGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MIPOL1 Gene

Variant ID Type Subtype PubMed ID
nsv901635 CNV Gain 21882294
dgv1876n71 CNV Loss 21882294
nsv901638 CNV Loss 21882294
nsv901639 CNV Loss 21882294
esv2617029 CNV Loss 19546169
nsv511542 CNV Loss 21212237
esv23551 CNV Gain 19812545
nsv821405 CNV Deletion 20802225
nsv901640 CNV Loss 21882294
esv2632367 CNV Insertion 19546169
esv268493 CNV Insertion 20981092
esv273044 CNV Insertion 20981092
nsv901641 CNV Loss 21882294
nsv826923 CNV Gain 20364138

Relevant External Links for MIPOL1 Gene

HapMap Linkage Disequilibrium report
MIPOL1
Human Gene Mutation Database (HGMD)
MIPOL1

Disorders for MIPOL1 Gene

(1) OMIM Diseases for MIPOL1 Gene (606850)

UniProtKB/Swiss-Prot

MIPO1_HUMAN
  • Note=A chromosomal aberration involving MIPOL1 is found in a patient with mirror-image polydactyly of hands and feet without other anomalies (MIP). Translocation t(2;14)(p23.3;q13). MIP is a very rare congenital anomaly characterized by mirror-image duplication of digits. MIP is occasionally associated with dimelia of the ulna and fibula, tibial and/or fibular hypoplasia, nasal abnormality and other malformations. Most MIP cases are sporadic, but very rare parent-child transmissions observed in familial cases suggest an autosomal mode of inheritance.

Relevant External Links for MIPOL1

Genetic Association Database (GAD)
MIPOL1
Human Genome Epidemiology (HuGE) Navigator
MIPOL1
genes like me logo Genes that share disorders with MIPOL1: view

Publications for MIPOL1 Gene

  1. A novel gene is disrupted at a 14q13 breakpoint of t(2;14) in a patient with mirror-image polydactyly of hands and feet. (PMID: 11954550) Kondoh S. … Yoshiura K. (J. Hum. Genet. 2002) 2 3 4 23
  2. Rearrangement in the PITX2 and MIPOL1 genes in a patient with a t(4;14) chromosome. (PMID: 12700605) Kamnasaran D. … Cox D.W. (Eur. J. Hum. Genet. 2003) 3 23
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Chromosome 14 transfer and functional studies identify a candidate tumor suppressor gene, mirror image polydactyly 1, in nasopharyngeal carcinoma. (PMID: 19667180) Cheung A.K. … Lung M.L. (Proc. Natl. Acad. Sci. U.S.A. 2009) 2 3
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49

Products for MIPOL1 Gene

Sources for MIPOL1 Gene

Back to Top

Content