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Aliases for MIPEP Gene

Aliases for MIPEP Gene

  • Mitochondrial Intermediate Peptidase 2 3 5
  • EC 3.4.24.59 4 63
  • MIP 3 4
  • HMIP 3

External Ids for MIPEP Gene

Previous GeneCards Identifiers for MIPEP Gene

  • GC13M022284
  • GC13M018284
  • GC13M023234
  • GC13M022102
  • GC13M023202
  • GC13M024304
  • GC13M005115

Summaries for MIPEP Gene

Entrez Gene Summary for MIPEP Gene

  • The product of this gene performs the final step in processing a specific class of nuclear-encoded proteins targeted to the mitochondrial matrix or inner membrane. This protein is primarily involved in the maturation of oxidative phosphorylation (OXPHOS)-related proteins. This gene may contribute to the functional effects of frataxin deficiency and the clinical manifestations of Friedreich ataxia. [provided by RefSeq, Jul 2008]

GeneCards Summary for MIPEP Gene

MIPEP (Mitochondrial Intermediate Peptidase) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Aquaporin-mediated transport. GO annotations related to this gene include metalloendopeptidase activity.

UniProtKB/Swiss-Prot for MIPEP Gene

  • Cleaves proteins, imported into the mitochondrion, to their mature size.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIPEP Gene

Genomics for MIPEP Gene

Regulatory Elements for MIPEP Gene

Promoters for MIPEP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MIPEP on UCSC Golden Path with GeneCards custom track

Genomic Location for MIPEP Gene

Chromosome:
13
Start:
23,730,188 bp from pter
End:
23,889,448 bp from pter
Size:
159,261 bases
Orientation:
Minus strand

Genomic View for MIPEP Gene

Genes around MIPEP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIPEP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIPEP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIPEP Gene

Proteins for MIPEP Gene

  • Protein details for MIPEP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99797-MIPEP_HUMAN
    Recommended name:
    Mitochondrial intermediate peptidase
    Protein Accession:
    Q99797
    Secondary Accessions:
    • Q5JV15
    • Q5T9Q9
    • Q96G65

    Protein attributes for MIPEP Gene

    Size:
    713 amino acids
    Molecular mass:
    80641 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Monomer.

neXtProt entry for MIPEP Gene

Proteomics data for MIPEP Gene at MOPED

Selected DME Specific Peptides for MIPEP Gene

Post-translational modifications for MIPEP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MIPEP Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains & Families for MIPEP Gene

Protein Domains for MIPEP Gene

Suggested Antigen Peptide Sequences for MIPEP Gene

Graphical View of Domain Structure for InterPro Entry

Q99797

UniProtKB/Swiss-Prot:

MIPEP_HUMAN :
  • Belongs to the peptidase M3 family.
Family:
  • Belongs to the peptidase M3 family.
genes like me logo Genes that share domains with MIPEP: view

No data available for Gene Families for MIPEP Gene

Function for MIPEP Gene

Molecular function for MIPEP Gene

GENATLAS Biochemistry:
mitochondrial intermediate peptidase,involved in the biogenesis of the oxidative phosphorylation system
UniProtKB/Swiss-Prot CatalyticActivity:
Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activity is divalent cation-dependent. It is stimulated by manganese, magnesium or calcium ions and reversibly inhibited by zinc, cobalt and iron (By similarity).
UniProtKB/Swiss-Prot Function:
Cleaves proteins, imported into the mitochondrion, to their mature size.

Enzyme Numbers (IUBMB) for MIPEP Gene

genes like me logo Genes that share phenotypes with MIPEP: view

Animal Model Products

miRNA for MIPEP Gene

miRTarBase miRNAs that target MIPEP

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MIPEP Gene

Localization for MIPEP Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIPEP Gene

Mitochondrion matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MIPEP Gene COMPARTMENTS Subcellular localization image for MIPEP gene
Compartment Confidence
mitochondrion 5
cytosol 2
nucleus 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for MIPEP Gene

Pathways & Interactions for MIPEP Gene

genes like me logo Genes that share pathways with MIPEP: view

Pathways by source for MIPEP Gene

Gene Ontology (GO) - Biological Process for MIPEP Gene

None

No data available for SIGNOR curated interactions for MIPEP Gene

Drugs & Compounds for MIPEP Gene

(6) Drugs for MIPEP Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cobalt Pharma 155
Manganese Pharma 32
calcium Nutra 0
Magnesium Nutra 0

(3) Additional Compounds for MIPEP Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Fe2+
  • Armco iron
  • Carbonyl iron
  • FE
  • Ferrovac e
  • Hematite
15438-31-0
genes like me logo Genes that share compounds with MIPEP: view

Transcripts for MIPEP Gene

Unigene Clusters for MIPEP Gene

Mitochondrial intermediate peptidase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MIPEP Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
SP1:
SP2:
SP3: -

Relevant External Links for MIPEP Gene

GeneLoc Exon Structure for
MIPEP
ECgene alternative splicing isoforms for
MIPEP

Expression for MIPEP Gene

mRNA expression in normal human tissues for MIPEP Gene

Protein differential expression in normal tissues from HIPED for MIPEP Gene

This gene is overexpressed in Esophagus (6.9), Adrenal (6.9), Tonsil (6.5), Uterus (6.4), and Salivary gland (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MIPEP Gene



SOURCE GeneReport for Unigene cluster for MIPEP Gene Hs.507498

genes like me logo Genes that share expression patterns with MIPEP: view

Protein tissue co-expression partners for MIPEP Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MIPEP Gene

Orthologs for MIPEP Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MIPEP Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MIPEP 35
  • 82.3 (n)
  • 89.35 (a)
MIPEP 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MIPEP 35
  • 90.09 (n)
  • 92.26 (a)
MIPEP 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mipep 35
  • 83.14 (n)
  • 85.57 (a)
Mipep 16
Mipep 36
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MIPEP 35
  • 99.63 (n)
  • 99.44 (a)
MIPEP 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mipep 35
  • 82.71 (n)
  • 86.21 (a)
oppossum
(Monodelphis domestica)
Mammalia MIPEP 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MIPEP 36
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves MIPEP 35
  • 76.63 (n)
  • 80.84 (a)
MIPEP 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MIPEP 36
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mipep 35
  • 72.31 (n)
  • 78.94 (a)
Str.10085 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.23844 35
zebrafish
(Danio rerio)
Actinopterygii Dr.29606 35
mipep 35
  • 69 (n)
  • 73.62 (a)
mipep 36
  • 72 (a)
OneToMany
MIPEP (1 of 2) 36
  • 71 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG7791 37
  • 48 (a)
CG7791 35
  • 52.53 (n)
  • 50.38 (a)
CG7791 36
  • 48 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007728 35
  • 56.11 (n)
  • 51.2 (a)
worm
(Caenorhabditis elegans)
Secernentea Y67H2A.7 37
  • 39 (a)
CELE_Y67H2A.7 35
  • 46.52 (n)
  • 36.11 (a)
Y67H2A.7 36
  • 33 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR198W 35
  • 47.09 (n)
  • 38.66 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B12397g 35
  • 44.65 (n)
  • 35.65 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes OCT1 35
  • 46.93 (n)
  • 34.88 (a)
OCT1 36
  • 30 (a)
OneToOne
OCT1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G51540 35
  • 47.83 (n)
  • 34.67 (a)
rice
(Oryza sativa)
Liliopsida Os06g0686500 35
  • 46.42 (n)
  • 34.36 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1536 35
bread mold
(Neurospora crassa)
Ascomycetes NCU02063 35
  • 45.05 (n)
  • 36.41 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes oct1 35
  • 48.08 (n)
  • 37.12 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.690 36
  • 49 (a)
OneToOne
Species with no ortholog for MIPEP:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MIPEP Gene

ENSEMBL:
Gene Tree for MIPEP (if available)
TreeFam:
Gene Tree for MIPEP (if available)

Paralogs for MIPEP Gene

Pseudogenes.org Pseudogenes for MIPEP Gene

genes like me logo Genes that share paralogs with MIPEP: view

No data available for Paralogs for MIPEP Gene

Variants for MIPEP Gene

Sequence variations from dbSNP and Humsavar for MIPEP Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs2312296 - 23,881,741(-) AGAAG(C/T)TGCGG reference, missense
rs11551114 - 23,862,336(-) GATAC(A/G)AGGGA reference, missense
rs12858248 - 23,837,737(+) CTCCA(C/T)GGATA reference, missense
rs7333040 - 23,837,633(+) CATGC(C/T)AGGAG reference, missense
rs16765 -- 23,844,175(+) GATGC(A/G)GGCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MIPEP Gene

Variant ID Type Subtype PubMed ID
esv2422502 CNV Duplication 17116639
esv2747122 CNV Deletion 23290073
esv5325 CNV Complex 18987735
nsv455837 CNV Gain 19166990
nsv525965 CNV Gain 19592680
dgv1561n71 CNV Gain 21882294
esv2751136 CNV Loss 17911159
dgv1565n71 CNV Gain 21882294
esv2747134 CNV Deletion 23290073
esv2659554 CNV Deletion 23128226
nsv899927 CNV Gain 21882294
nsv899928 CNV Loss 21882294
esv21543 CNV Gain 19812545
nsv832566 CNV Gain 17160897
esv2658569 CNV Deletion 23128226

Variation tolerance for MIPEP Gene

Residual Variation Intolerance Score: 94.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.85; 67.23% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MIPEP Gene

HapMap Linkage Disequilibrium report
MIPEP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MIPEP Gene

Disorders for MIPEP Gene

Relevant External Links for MIPEP

Genetic Association Database (GAD)
MIPEP
Human Genome Epidemiology (HuGE) Navigator
MIPEP
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIPEP

No disorders were found for MIPEP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIPEP Gene

Publications for MIPEP Gene

  1. Cloning, expression, and chromosomal assignment of the human mitochondrial intermediate peptidase gene (MIPEP). (PMID: 9073519) Chew A. … Isaya G. (Genomics 1997) 2 3 4 23 67
  2. Functional and genomic analysis of the human mitochondrial intermediate peptidase, a putative protein partner of frataxin. (PMID: 10783257) Chew A. … Isaya G. (Genomics 2000) 3 23
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Genome wide association study of fetal hemoglobin in sickle cell anemia in Tanzania. (PMID: 25372704) Mtatiro S.N. … Barrett J.C. (PLoS ONE 2014) 3
  5. Development and application of a DNA microarray-based yeast two-hybrid system. (PMID: 23275563) Suter B. … Wanker E.E. (Nucleic Acids Res. 2013) 3

Products for MIPEP Gene

Sources for MIPEP Gene

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