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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MIPEP Gene

protein-coding   GIFtS: 61
GCID: GC13M024304

Mitochondrial Intermediate Peptidase

Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Mitochondrial Intermediate Peptidase1 2
MIP2 3
EC 3.4.24.593 8
HMIP2

External Ids:    HGNC: 71041   Entrez Gene: 42852   Ensembl: ENSG000000270017   OMIM: 6022415   UniProtKB: Q997973   

Export aliases for MIPEP gene to outside databases

Previous GC identifers: GC13M022284 GC13M018284 GC13M023234 GC13M022102 GC13M023202 GC13M005115


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MIPEP Gene:
The product of this gene performs the final step in processing a specific class of nuclear-encoded proteins
targeted to the mitochondrial matrix or inner membrane. This protein is primarily involved in the maturation of
oxidative phosphorylation (OXPHOS)-related proteins. This gene may contribute to the functional effects of
frataxin deficiency and the clinical manifestations of Friedreich ataxia. (provided by RefSeq, Jul 2008)

GeneCards Summary for MIPEP Gene: 
MIPEP (mitochondrial intermediate peptidase) is a protein-coding gene. Diseases associated with MIPEP include friedreich ataxia, and ataxia. GO annotations related to this gene include metalloendopeptidase activity and metal ion binding.

UniProtKB/Swiss-Prot: MIPEP_HUMAN, Q99797
Function: Cleaves proteins, imported into the mitochondrion, to their mature size




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NT_024524.14  NC_018924.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MIPEP gene promoter:
         HFH-3   Lmo2   MIF-1   Ik-3   Meis-1b   FOXI1   HEN1   Ik-2   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMIPEP promoter sequence
   Search SABiosciences Chromatin IP Primers for MIPEP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MIPEP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q12   Ensembl cytogenetic band:  13q12.12   HGNC cytogenetic band: 13q12

MIPEP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MIPEP gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M024304:  view genomic region     (about GC identifiers)

Start:
24,304,328 bp from pter      End:
24,463,587 bp from pter
Size:
159,260 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MIPEP_HUMAN, Q99797 (See protein sequence)
Recommended Name: Mitochondrial intermediate peptidase precursor  
Size: 713 amino acids; 80641 Da
Cofactor: Binds 1 zinc ion (By similarity)
Subunit: Monomer (By similarity)
Subcellular location: Mitochondrion matrix
Secondary accessions: Q5JV15 Q5T9Q9 Q96G65

Explore the universe of human proteins at neXtProt for MIPEP: NX_Q99797

Explore proteomics data for MIPEP at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q99797

  • 3 DME Specific Peptides for MIPEP (Q99797)
     HSMLGRT  TAWQLRFSHLVGYGA  VSTSWSPVGAAFNVKPQ 

    MIPEP Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MIPEP Protein Expression
    REFSEQ proteins: NP_005923.2  
    ENSEMBL proteins: 
     ENSP00000397404   ENSP00000371607  

    Human Recombinant Protein Products for MIPEP: 
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    Novus Biologicals MIPEP Protein
    Novus Biologicals MIPEP Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MIPEP 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IDA--
    GO:0005759mitochondrial matrix IEA--

    MIPEP for ontologies           About GeneDecksing



    MIPEP Antibody Products: 
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    Cloud-Clone Corp. ELISAs for MIPEP 
    Cloud-Clone Corp. CLIAs for MIPEP


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR024079 MetalloPept_cat_dom
     IPR024077 Neurolysin/TOP_dom2
     IPR001567 Pept_M3A_M3B
     IPR024080 Neurolysin/TOP_N

    Graphical View of Domain Structure for InterPro Entry Q99797

    ProtoNet protein and cluster: Q99797

    1 Blocks protein domain: IPB001567 Peptidase M3

    UniProtKB/Swiss-Prot: MIPEP_HUMAN, Q99797
    Similarity: Belongs to the peptidase M3 family


    MIPEP for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MIPEP_HUMAN, Q99797
    Function: Cleaves proteins, imported into the mitochondrion, to their mature size
    Catalytic activity: Release of an N-terminal octapeptide as second stage of processing of some proteins imported
    into the mitochondrion
    Enzyme regulation: Activity is divalent cation-dependent. It is stimulated by manganese, magnesium or calcium ions
    and reversibly inhibited by zinc, cobalt and iron (By similarity)

         Genatlas biochemistry entry for MIPEP:
    mitochondrial intermediate peptidase,involved in the biogenesis of the oxidative phosphorylation system

         Enzyme Number (IUBMB): EC 3.4.24.591 2

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004222metalloendopeptidase activity IEA--
    GO:0046872metal ion binding IEA--
         
    MIPEP for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for MIPEP:
     High actin ratio cells  Increased G1 DNA content 

         1 MGI phenotypic allele for Mipep (no phenotypes)

    MIPEP for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for MIPEP 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MIPEP

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MIPEP 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MIPEP 

    miRNA
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    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate MIPEP
    SwitchGear 3'UTR luciferase reporter plasmidMIPEP 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
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    Gene Editing
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    Sino Biological Human cDNA Clone for MIPEP
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MIPEP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MIPEP
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                         Customized lentivirus expression plasmids for stable overexpression of MIPEP 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MIPEP


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MIPEP

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/27 Interacting proteins for MIPEP (Q997972, 3 ENSP000003716074) via UniProtKB, MINT, STRING, and/or I2D (see all 27)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAPK6Q166592, 3MINT-8261483 I2D: score=2 
    ILKQ134182, 3, ENSP000002994214MINT-8258599 I2D: score=2 STRING: ENSP00000299421
    MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
    GTF2BQ004033I2D: score=4 
    ARL1P406163I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IEA--
    GO:0006627protein processing involved in protein targeting to mitochondrion TAS9073519

    MIPEP for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MIPEP for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MIPEP

    5 HMDB Compounds for MIPEP    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    CobaltCo (see all 6)7440-48-4--
    IronArmco iron (see all 19)7439-89-6--
    MagnesiumMagnesium (see all 2)7439-95-4--
    Manganesemanganese 7439-96-5--

    4 Novoseek inferred chemical compound relationships for MIPEP gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ornithine 56.8 2 1672532 (1), 1560019 (1)
    iron-sulfur 51.8 1 1672532 (1)
    malate 44.6 2 1672532 (1), 1560019 (1)
    iron 6.11 1 10332043 (1)

    Search CenterWatch for drugs/clinical trials and news about MIPEP

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MIPEP gene: 
    NM_005932.3  

    Unigene Cluster for MIPEP:

    Mitochondrial intermediate peptidase
    Hs.507498  [show with all ESTs]
    Unigene Representative Sequence: NM_005932
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000464194 ENST00000433710 ENST00000382172(uc001uox.4) ENST00000494139
    ENST00000469167

    miRNA
    Products:
         
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    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate MIPEP
    SwitchGear 3'UTR luciferase reporter plasmidMIPEP 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MIPEP
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MIPEP
    Clone
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    OriGene ORF clones in mouse, rat for MIPEP
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    GenScript: all cDNA clones in your preferred vector: MIPEP (NM_005932)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MIPEP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MIPEP
    Sirion Biotech Customized lentivirus for stable overexpression of MIPEP 
                         Customized lentivirus expression plasmids for stable overexpression of MIPEP 
    Primer
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    OriGene qPCR primer pairs and template standards for MIPEP
    OriGene qSTAR qPCR primer pairs in human, mouse for MIPEP
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MIPEP
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MIPEP
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MIPEP

    Additional mRNA sequence: 

    AK225290.1 AK291923.1 AK308908.1 BC009934.2 U80034.1 

    11 DOTS entries:

    DT.113047  DT.92437588  DT.100837789  DT.70102470  DT.100774568  DT.100774574  DT.113048  DT.120769751 
    DT.120769758  DT.91910060  DT.92437589 

    24/118 AceView cDNA sequences (see all 118):

    BU687034 AU132796 BE695059 BQ270980 CF541033 CR616891 AA341752 BM828947 
    BM924599 BP365848 BM478969 AI201673 CB306951 CB306711 BX106440 BG576150 
    BM678777 CA423434 BP365890 BM720497 BM920821 BC009934 F28007 CB269894 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for MIPEP    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
    SP1:                                                            
    SP2:                                                            
    SP3:        -                                                   


    ECgene alternative splicing isoforms for MIPEP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MIPEP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAGATAATGA
    MIPEP Expression
    About this image


    See MIPEP Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MIPEP

    SOURCE GeneReport for Unigene cluster: Hs.507498
        SABiosciences Expression via Pathway-Focused PCR Array including MIPEP: 
              Mitochondria in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MIPEP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MIPEP gene from 10/24 species (see all 24)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mipep1 , 5 mitochondrial intermediate peptidase1, 5 82.81(n)1
    85.29(a)1
      14 (31.95 cM)5
    704781  NM_027436.31  NP_081712.21 
     607845665 
    chicken
    (Gallus gallus)
    Aves MIPEP1 mitochondrial intermediate peptidase 76.18(n)
    80.06(a)
      418942  XM_417136.3  XP_417136.2 
    lizard
    (Anolis carolinensis)
    Reptilia MIPEP6
    Uncharacterized protein
    78(a)
    1 ↔ 1
    3(188795027-188863814)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.238442 Xenopus laevis transcribed sequence with moderate similarity more 77.05(n)    BU913760.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.296062 Transcribed sequence with moderate similarity to protein more 75.41(n)    CD758926.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG77911 , 3 mitochondrial intermediate peptidase3
    CG77911
    48(a)3
    52.22(n)1
    49.78(a)1
      41F93
    355111  NM_136339.21  NP_610183.11 
    worm
    (Caenorhabditis elegans)
    Secernentea Y67H2A.73
    CELE_Y67H2A.71
    Protein Y67H2A.71 39(a)3
    46.67(n)1
    35.97(a)1
      IV(13303921-13310875)3
    1782901  NM_070157.31  NP_502558.21 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes OCT1(YKL134C)4
    OCT11
    Mitochondrial intermediate peptidase, cleaves destabilizing more4
    Oct1p1
    46.72(n)1
    34.72(a)1
      11(191442-189124)4
    8537241, 4  NP_012788.21  NP_012788.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G515401 mitochondrial intermediate peptidase 47.78(n)
    34.83(a)
      835228  NM_124533.2  NP_199967.2 
    rice
    (Oryza sativa)
    Liliopsida Os06g06865001 hypothetical protein 46.42(n)
    34.36(a)
      4341884  NM_001064936.1  NP_001058401.1 


    ENSEMBL Gene Tree for MIPEP (if available)
    TreeFam Gene Tree for MIPEP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MIPEP gene

    MIPEP for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for MIPEP
    PGOHUM00000248519 PGOHUM00000244501 PGOHUM00000232965


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3499 SNPs in MIPEP are shown (see all 3499)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0389374
    ----see VAR_0389372 S G mis40--------
    rs1830412641,2
    --5258125(+) ACTTAC/TTAATT 1 -- ds50010--------
    rs1437736741,2
    --5258250(+) CCACAC/TTTGGT 1 -- ds50010--------
    rs1868355281,2
    --5258375(+) GACTGC/TTTCAA 1 -- ds50010--------
    rs340426141,2
    C--5258566(+) ATATTT/GGCCAA 1 -- ds50011Minor allele frequency- G:0.00NA 2
    rs1481301381,2
    --5258681(+) TCTCAC/TAGCTG 1 -- ut310--------
    rs1917131941,2
    --5258689(+) CTGTAA/GCATTT 1 -- ut310--------
    rs1503081231,2
    C,F--5258846(+) GCATAC/TCTGCA 2 D G mis11Minor allele frequency- T:0.00NA 4548
    rs1147231351,2
    C,F--5259090(+) TAAATA/GTATTT 1 -- int11Minor allele frequency- G:0.03WA 118
    rs38293451,2
    C,F,A,H--5259279(+) TAGAAA/TTCTTA 1 -- int19Minor allele frequency- T:0.32NA WA CSA EA 368

    HapMap Linkage Disequilibrium report for MIPEP (24304328 - 24463587 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/15 variations for MIPEP (see all 15):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2659554CNV Deletion23128226
    esv2658569CNV Deletion23128226
    esv2747122CNV Deletion23290073
    esv2747134CNV Deletion23290073
    esv2422502CNV Duplication17116639
    nsv899928CNV Loss21882294
    esv2751136CNV Loss17911159
    nsv832566CNV Gain17160897
    nsv899927CNV Gain21882294
    nsv525965CNV Gain19592680

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602241    OMIM disorders: --

    5 diseases for MIPEP:    About MalaCards
    friedreich ataxia    ataxia    myopia    hypoxia
    neuronitis


    MIPEP for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    2 Novoseek inferred disease relationships for MIPEP gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    friedreich ataxia 60.8 3 10783257 (1)
    neurodegenerative diseases 21.2 4 10783257 (2)

    Genetic Association Database (GAD): MIPEP
    Human Genome Epidemiology (HuGE) Navigator: MIPEP (1 document)

    Export disorders for MIPEP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MIPEP gene, integrated from 9 sources (see all 37):
    (articles sorted by number of sources associating them with MIPEP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, expression, and chromosomal assignment of the human mitochondrial intermediate peptidase gene (MIPEP). (PubMed id 9073519)1, 2, 3, 9 Chew A.... Isaya G. (1997)
    2. Genetic variants at 13q12.12 are associated with high myopia in the Han Chinese population. (PubMed id 21640322)1, 4 Shi Y....Yang Z. (2011)
    3. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    4. Functional and genomic analysis of the human mitochondrial intermediate peptidase, a putative protein partner of frataxin. (PubMed id 10783257)1, 9 Chew A....Isaya G. (2000)
    5. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PubMed id 22589738)1 Fox C.S....Borecki I.B. (2012)
    6. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    7. A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
    8. A genome-wide association study identifies two new lun g cancer susceptibility loci at 13q12.12 and 22q12.2 in Han Chinese. (PubMed id 21725308)1 Hu Z....Shen H. (2011)
    9. Proteomic profiling of Myc-associated proteins. (PubMed id 21150319)1 Agrawal P....Sedivy J.M. (2010)
    10. Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4285 HGNC: 7104 AceView: MIPEP Ensembl:ENSG00000027001 euGenes: HUgn4285
    ECgene: MIPEP H-InvDB: MIPEP

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MIPEP Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MIPEP Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MIPEP gene:
    Search GeneIP for patents involving MIPEP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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