MIOX Gene

Aliases
for MIOX gene

Previous GC identifers: GC22P049216 GC22P049272 GC22P033815

Summaries
for MIOX gene

Genomic Views
for MIOX gene

RefSeq DNA sequence:

NC_000022.10  NC_018933.1  NT_011526.7  

SwitchGear Promoter luciferase reporter plasmid: MIOX promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MIOX

MIOX Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P050925:  view genomic region     (about GC identifiers)

Proteins
for MIOX gene

1 PDB 3D structure from and Proteopedia for MIOX:

2IBN (3D)    

Explore the universe of human proteins at neXtProt for MIOX: NX_Q9UGB7

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: MIOX OriGene Protein Over-expression Lysate: MIOX OriGene Custom Protein Services for MIOX
	GenScript Custom Purified and Recombinant Proteins Services for MIOX
	Novus Biologicals MIOX Protein Novus Biologicals MIOX Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for MIOX

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	OriGene Antibodies (see all 12): MIOX OriGene Custom Antibody Services for MIOX
	GenScript Custom Superior Antibodies Services for MIOX
	Novus Biologicals MIOX Antibodies
	Search for Antibodies for MIOX at Abcam
	Uscn Antibodies for MIOX
	Search ThermoFisher Antibodies for MIOX

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for MIOX
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for MIOX

Protein Domains /
Families
for MIOX gene

ProtoNet protein and cluster: Q9UGB7

Function
for MIOX gene

Enzyme Number (IUBMB): EC 1.13.99.1^{1 2}

miRNA Products:		OriGene 3'-UTR Clone: MIOX Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MIOX
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate MIOX
		SwitchGear 3'UTR luciferase reporter plasmid: MIOX 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MIOX (see all 7) OriGene shRNA RFP: MIOX OriGene siRNA: MIOX
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MIOX

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for MIOX

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MIOX (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MIOX OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: MIOX (NM_017584)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MIOX
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MIOX

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for MIOX
		Search LifeMap BioReagents cell lines for MIOX

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MIOX

Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

Pathways & Interactions
for MIOX gene

	Super-pathway	contained gene-specific pathways
1	Inositol phosphate metabolism	Inositol phosphate metabolism 1.00
2	Pentose and glucuronate interconversions	Ascorbate and aldarate metabolism 0.62

2         Kegg Pathways  (Kegg details for MIOX)

	Ascorbate and aldarate metabolism
	Inositol phosphate metabolism

MIOX for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for MIOX

STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

5/6 Interacting proteins for MIOX (Q9UGB7³ ENSP00000216075⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 6)

Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

Drugs & Compounds
for MIOX gene

Transcripts
for MIOX gene

Expression
for MIOX gene

MIOX expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGCCCTGGG

Stem Cell Differentiation: 1 LifeMap Cell
	Name			Category
	Secondary follicles (Primary Cell)			Ovary, Reproductive System
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MIOX Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MIOX
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MIOX
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MIOX

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MIOX

Orthologs
for MIOX gene

Paralogs
for MIOX gene

Paralogs for MIOX gene

MIOX for paralogs           About GeneDecksing


1 Pseudogenes.org Pseudogene for MIOX
PGOHUM00000249420

Genomic Variants
for MIOX gene

10/250 NCBI SNPs in MIOX are shown (see all 250)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 22 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1424365761,2		--	50923215(+)	CCCTCC/TGTGTC	3	--	us2k1 ut31		0	--	--	--	--
rs7617451,2	C,F,O,H,	--	50923217(+)	CTCCGC/TGTCGC	3	--	ut31 us2k1		21		MN NS EA NA WA CSA	2525
rs60099711,2	C,A,H	--	50923282(+)	CTGCAC/ACCACT	3	--	ut31 us2k1		5		NS EA NA	420
rs1390109621,2	C,	--	50923282(+)	TGCAC-/CCACCCCCAC CTTCCCCAGCAACCACT	3	--	ut31 us2k1		0	--	--	--	--
rs1158172971,2	C	--	50923288(+)	CCACTC/TCCAGC	3	--	ut31 us2k1		0	--	--	--	--
rs1814383591,2		--	50923386(+)	CTGAGG/TTCAGG	3	--	ut31 us2k1		0	--	--	--	--
rs622394831,2	C,F,	--	50923390(+)	GTTCAG/CGAGTT	3	--	ut31 us2k1		2		NA	4
rs43420451,2	C,F,A,	--	50923408(+)	AGCCTA/GGCCAA	3	--	ut31 us2k1		5		NA WA CSA	9
rs1504520391,2		--	50923420(+)	ATGGTA/GAAATC	3	--	ut31 us2k1		0	--	--	--	--
rs355533991,2	C	--	50923776(+)	GTTTC-/AAAAAA	3	--	ut31 us2k1		1		CSA	2

HapMap Linkage Disequilibrium report for MIOX (50925213 - 50929077 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for MIOX
     1 CNV: 5192

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MIOX

DNA2.0 Custom Variant and Variant Library Synthesis for MIOX

Disorders / Diseases
for MIOX gene

Publications
for MIOX gene

PubMed articles for MIOX gene, integrated from 9 sources (see all 28): (articles sorted by number of sources associating them with MIOX)

Utopia: connect your pdf to the dynamic world of online information

1. Identification of a renal-specific oxido-reductase in newborn diabetic mice. (PubMed id 10944187)^{1, 2, 3} Yang Q....Kanwar Y.S. (2000)
2. Molecular cloning, expression, and characterization of myo-inositol oxygenase from mouse, rat, and human kidney. (PubMed id 15504367)^{1, 2, 9} Arner R.J.... Reddy C.C. (2004)
3. Structural and biophysical characterization of human myo-inositol oxygenase. (PubMed id 18364358)^{1, 2, 9} Thorsell A.G....Hallberg B.M. (2008)
4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
6. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)^{1, 2} Collins J.E.... Dunham I. (2004)
7. myo-Inositol oxygenase: molecular cloning and expression of a unique enzyme that oxidizes myo-inositol and D-chiro-inositol. (PubMed id 11716759)^{1, 3} Arner R.J....Reddy C.C. (2001)
8. The DNA sequence of human chromosome 22. (PubMed id 10591208)^{1, 2} Dunham I....O'Brien K.P. (1999)
9. Up-regulation of human myo-inositol oxygenase by hyperosmotic stress in renal proximal tubular epithelial cells. (PubMed id 15778219)^{1, 9} Prabhu K.S....Reddy C.C. (2005)
10. Polymorphisms of myo-inositol oxygenase gene are asso ciated with Type 1 diabetes mellitus. (PubMed id 19896870)¹ Yang B....Demaine A.G. (2009)

External Searches for MIOX gene

Genome Databases showing MIOX gene

Other Databases showing MIOX gene

Specialized Databases showing MIOX gene

Products
for MIOX gene