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Aliases for MIOX Gene

Aliases for MIOX Gene

  • Myo-Inositol Oxygenase 2 3 4
  • Kidney-Specific Protein 32 2 3 4
  • Aldehyde Reductase (Aldose Reductase) Like 6 2 3
  • Renal-Specific Oxidoreductase 3 4
  • Aldehyde Reductase-Like 6 3 4
  • MI Oxygenase 3 4
  • EC 1.13.99.1 4 63
  • ALDRL6 3 4
  • Inositol Oxygenase 3
  • KSP32 4
  • RSOR 4

External Ids for MIOX Gene

Previous HGNC Symbols for MIOX Gene

  • ALDRL6

Previous GeneCards Identifiers for MIOX Gene

  • GC22P049216
  • GC22P049272
  • GC22P050925
  • GC22P033815

Summaries for MIOX Gene

GeneCards Summary for MIOX Gene

MIOX (Myo-Inositol Oxygenase) is a Protein Coding gene. Among its related pathways are Inositol phosphate metabolism (KEGG) and Glucuronidation. GO annotations related to this gene include NADP binding and aldo-keto reductase (NADP) activity.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIOX Gene

Genomics for MIOX Gene

Regulatory Elements for MIOX Gene

Genomic Location for MIOX Gene

Start:
50,486,784 bp from pter
End:
50,490,648 bp from pter
Size:
3,865 bases
Orientation:
Plus strand

Genomic View for MIOX Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIOX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIOX Gene

Proteins for MIOX Gene

  • Protein details for MIOX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UGB7-MIOX_HUMAN
    Recommended name:
    Inositol oxygenase
    Protein Accession:
    Q9UGB7
    Secondary Accessions:
    • Q05DJ6
    • Q5S8C9
    • Q9BZZ1
    • Q9UHB8

    Protein attributes for MIOX Gene

    Size:
    285 amino acids
    Molecular mass:
    33010 Da
    Cofactor:
    Name=Fe cation; Xref=ChEBI:CHEBI:24875; Note=Binds 2 iron ions per subunit.;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for MIOX Gene

    Alternative splice isoforms for MIOX Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MIOX Gene

Proteomics data for MIOX Gene at MOPED

Post-translational modifications for MIOX Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MIOX Gene

Domains for MIOX Gene

Protein Domains for MIOX Gene

Suggested Antigen Peptide Sequences for MIOX Gene

Graphical View of Domain Structure for InterPro Entry

Q9UGB7

UniProtKB/Swiss-Prot:

MIOX_HUMAN :
  • Q9UGB7
Family:
  • Belongs to the myo-inositol oxygenase family.
genes like me logo Genes that share domains with MIOX: view

No data available for Gene Families for MIOX Gene

Function for MIOX Gene

Molecular function for MIOX Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Myo-inositol + O(2) = D-glucuronate + H(2)O.

Enzyme Numbers (IUBMB) for MIOX Gene

Gene Ontology (GO) - Molecular Function for MIOX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004033 aldo-keto reductase (NADP) activity ISS --
GO:0005506 iron ion binding --
GO:0008199 ferric iron binding IDA 18364358
GO:0016651 oxidoreductase activity, acting on NAD(P)H IEA --
GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ISS --
genes like me logo Genes that share ontologies with MIOX: view

Phenotypes for MIOX Gene

GenomeRNAi human phenotypes for MIOX:
genes like me logo Genes that share phenotypes with MIOX: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MIOX

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MIOX Gene

Localization for MIOX Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIOX Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MIOX Gene COMPARTMENTS Subcellular localization image for MIOX gene
Compartment Confidence
cytosol 3
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for MIOX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm ISS --
GO:0016234 inclusion body ISS --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with MIOX: view

Pathways for MIOX Gene

genes like me logo Genes that share pathways with MIOX: view

Pathways by source for MIOX Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

UniProtKB/Swiss-Prot Q9UGB7-MIOX_HUMAN

  • Pathway: Polyol metabolism; myo-inositol degradation into D-glucuronate; D-glucuronate from myo-inositol: step 1/1

Interacting Proteins for MIOX Gene

Gene Ontology (GO) - Biological Process for MIOX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019310 inositol catabolic process ISS --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with MIOX: view

Compounds for MIOX Gene

(5) HMDB Compounds for MIOX Gene

Compound Synonyms Cas Number PubMed IDs
D-Glucuronic acid
  • D-(+)-glucuronate
6556-12-3
Iron
  • Armco iron
7439-89-6
Myoinositol
  • MI
87-89-8
Oxygen
  • Oxygen
7782-44-7
Water
  • Dihydrogen oxide
7732-18-5

(9) Novoseek inferred chemical compound relationships for MIOX Gene

Compound -log(P) Hits PubMed IDs
hematite 95.3 46
inositol 84.4 34
glucuronic acid 82.6 6
d-glucuronic acid 77.6 2
glycol 72.6 2
genes like me logo Genes that share compounds with MIOX: view

Transcripts for MIOX Gene

Unigene Clusters for MIOX Gene

Myo-inositol oxygenase:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MIOX

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIOX Gene

No ASD Table

Relevant External Links for MIOX Gene

GeneLoc Exon Structure for
MIOX
ECgene alternative splicing isoforms for
MIOX

Expression for MIOX Gene

mRNA expression in normal human tissues for MIOX Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MIOX Gene

This gene is overexpressed in Kidney - Cortex (50.8).

Protein differential expression in normal tissues for MIOX Gene

This gene is overexpressed in Kidney (68.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for MIOX Gene

SOURCE GeneReport for Unigene cluster for MIOX Gene Hs.129227

mRNA Expression by UniProt/SwissProt for MIOX Gene

Q9UGB7-MIOX_HUMAN
Tissue specificity: Kidney specific
genes like me logo Genes that share expressions with MIOX: view

Expression partners for MIOX Gene

In Situ Assay Products

Orthologs for MIOX Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MIOX Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MIOX 35
  • 87.72 (n)
  • 86.67 (a)
MIOX 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MIOX 35
  • 86.78 (n)
  • 88.77 (a)
MIOX 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Miox 35
  • 86.08 (n)
  • 89.82 (a)
Miox 16
Miox 36
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Miox 35
  • 85.5 (n)
  • 90.53 (a)
oppossum
(Monodelphis domestica)
Mammalia MIOX 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MIOX 36
  • 70 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MIOX 36
  • 100 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia miox 35
  • 66.67 (n)
  • 70.5 (a)
zebrafish
(Danio rerio)
Actinopterygii miox 35
  • 68.82 (n)
  • 67.63 (a)
miox 36
  • 67 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9888 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003636 35
  • 61.78 (n)
  • 58.97 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6910 35
  • 62.42 (n)
  • 57.09 (a)
CG6910 36
  • 53 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C54E4.5 35
  • 57.38 (n)
  • 51.91 (a)
C54E4.5 36
  • 50 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR482W 35
  • 51.84 (n)
  • 44.49 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E10737g 35
  • 49.93 (n)
  • 45.88 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons MIOX1 35
  • 55.04 (n)
  • 48.06 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.6304 35
barley
(Hordeum vulgare)
Liliopsida Hv.1000 35
rice
(Oryza sativa)
Liliopsida Os.6345 35
Os06g0561000 35
  • 62.13 (n)
  • 50.19 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.2631 35
corn
(Zea mays)
Liliopsida Zm.16227 35
bread mold
(Neurospora crassa)
Ascomycetes NCU08856 35
  • 52.64 (n)
  • 44.4 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.33 36
  • 57 (a)
OneToOne
Species with no ortholog for MIOX:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for MIOX Gene

ENSEMBL:
Gene Tree for MIOX (if available)
TreeFam:
Gene Tree for MIOX (if available)

Paralogs for MIOX Gene

Pseudogenes.org Pseudogenes for MIOX Gene

genes like me logo Genes that share paralogs with MIOX: view

No data available for Paralogs for MIOX Gene

Variants for MIOX Gene

Sequence variations from dbSNP and Humsavar for MIOX Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs1055271 -- 50,489,911(+) GCCTG(C/G)AGAGG utr-variant-3-prime, nc-transcript-variant
rs1055272 -- 50,489,913(+) CTGGA(A/G)AGGCC utr-variant-3-prime, nc-transcript-variant
rs1064043 -- 50,490,015(+) CCTGG(C/G)GTCAA utr-variant-3-prime, nc-transcript-variant
rs2232875 -- 50,486,963(+) CTGGT(A/G)GCCAG intron-variant, upstream-variant-2KB
rs2232876 -- 50,486,976(+) ACTCC(C/T)GCCCT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIOX Gene

Variant ID Type Subtype PubMed ID
nsv915495 CNV Loss 21882294
nsv914525 CNV Loss 21882294
dgv5062n71 CNV Loss 21882294
nsv834238 CNV Loss 17160897
dgv5063n71 CNV Loss 21882294
nsv914541 CNV Loss 21882294
nsv471224 CNV Loss 18288195
nsv914542 CNV Loss 21882294
nsv914543 CNV Loss 21882294
nsv829338 CNV Gain 20364138
nsv914544 CNV Loss 21882294
nsv3669 CNV Insertion 18451855
dgv5064n71 CNV Loss 21882294
dgv5065n71 CNV Loss 21882294
nsv834239 CNV Loss 17160897

Relevant External Links for MIOX Gene

HapMap Linkage Disequilibrium report
MIOX

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MIOX Gene

Disorders for MIOX Gene

Relevant External Links for MIOX

Genetic Association Database (GAD)
MIOX
Human Genome Epidemiology (HuGE) Navigator
MIOX

No disorders were found for MIOX Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for MIOX Gene

Publications for MIOX Gene

  1. Molecular cloning, expression, and characterization of myo-inositol oxygenase from mouse, rat, and human kidney. (PMID: 15504367) Arner R.J. … Reddy C.C. (Biochem. Biophys. Res. Commun. 2004) 3 4 23
  2. Structural and biophysical characterization of human myo-inositol oxygenase. (PMID: 18364358) Thorsell A.G. … Hallberg B.M. (J. Biol. Chem. 2008) 3 4 23
  3. Identification of a renal-specific oxido-reductase in newborn diabetic mice. (PMID: 10944187) Yang Q. … Kanwar Y.S. (Proc. Natl. Acad. Sci. U.S.A. 2000) 2 3 4
  4. myo-Inositol oxygenase: molecular cloning and expression of a unique enzyme that oxidizes myo-inositol and D-chiro-inositol. (PMID: 11716759) Arner R.J. … Reddy C.C. (Biochem. J. 2001) 2 3
  5. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 3 4

Products for MIOX Gene

Sources for MIOX Gene

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