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Aliases for MIOX Gene

Aliases for MIOX Gene

  • Myo-Inositol Oxygenase 2 3 4 5
  • Kidney-Specific Protein 32 2 3 4
  • Aldehyde Reductase (Aldose Reductase) Like 6 2 3
  • Renal-Specific Oxidoreductase 3 4
  • Aldehyde Reductase-Like 6 3 4
  • MI Oxygenase 3 4
  • EC 1.13.99.1 4 63
  • ALDRL6 3 4
  • KSP32 4
  • RSOR 4

External Ids for MIOX Gene

Previous HGNC Symbols for MIOX Gene

  • ALDRL6

Previous GeneCards Identifiers for MIOX Gene

  • GC22P049216
  • GC22P049272
  • GC22P050925
  • GC22P033815

Summaries for MIOX Gene

GeneCards Summary for MIOX Gene

MIOX (Myo-Inositol Oxygenase) is a Protein Coding gene. Among its related pathways are Inositol phosphate metabolism (KEGG) and Porphyrin and chlorophyll metabolism. GO annotations related to this gene include iron ion binding and oxidoreductase activity, acting on NAD(P)H.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIOX Gene

Genomics for MIOX Gene

Regulatory Elements for MIOX Gene

Enhancers for MIOX Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MIOX on UCSC Golden Path with GeneCards custom track

Promoters for MIOX Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MIOX on UCSC Golden Path with GeneCards custom track

Genomic Location for MIOX Gene

Chromosome:
22
Start:
50,483,988 bp from pter
End:
50,490,648 bp from pter
Size:
6,661 bases
Orientation:
Plus strand

Genomic View for MIOX Gene

Genes around MIOX on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIOX Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIOX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIOX Gene

Proteins for MIOX Gene

  • Protein details for MIOX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UGB7-MIOX_HUMAN
    Recommended name:
    Inositol oxygenase
    Protein Accession:
    Q9UGB7
    Secondary Accessions:
    • Q05DJ6
    • Q5S8C9
    • Q9BZZ1
    • Q9UHB8

    Protein attributes for MIOX Gene

    Size:
    285 amino acids
    Molecular mass:
    33010 Da
    Cofactor:
    Name=Fe cation; Xref=ChEBI:CHEBI:24875;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for MIOX Gene

    Alternative splice isoforms for MIOX Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MIOX Gene

Proteomics data for MIOX Gene at MOPED

Post-translational modifications for MIOX Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MIOX Gene

Domains & Families for MIOX Gene

Protein Domains for MIOX Gene

Suggested Antigen Peptide Sequences for MIOX Gene

Graphical View of Domain Structure for InterPro Entry

Q9UGB7

UniProtKB/Swiss-Prot:

MIOX_HUMAN :
  • Belongs to the myo-inositol oxygenase family.
Family:
  • Belongs to the myo-inositol oxygenase family.
genes like me logo Genes that share domains with MIOX: view

No data available for Gene Families for MIOX Gene

Function for MIOX Gene

Molecular function for MIOX Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Myo-inositol + O(2) = D-glucuronate + H(2)O.

Enzyme Numbers (IUBMB) for MIOX Gene

Gene Ontology (GO) - Molecular Function for MIOX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004033 aldo-keto reductase (NADP) activity ISS --
GO:0005506 iron ion binding IEA --
GO:0008199 ferric iron binding IDA 18364358
GO:0016651 oxidoreductase activity, acting on NAD(P)H IEA --
genes like me logo Genes that share ontologies with MIOX: view
genes like me logo Genes that share phenotypes with MIOX: view

Animal Model Products

  • Taconic Biosciences Mouse Models for MIOX

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MIOX Gene

Localization for MIOX Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIOX Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MIOX Gene COMPARTMENTS Subcellular localization image for MIOX gene
Compartment Confidence
extracellular 5
cytosol 4
nucleus 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for MIOX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,ISS --
genes like me logo Genes that share ontologies with MIOX: view

Pathways & Interactions for MIOX Gene

genes like me logo Genes that share pathways with MIOX: view

Pathways by source for MIOX Gene

UniProtKB/Swiss-Prot Q9UGB7-MIOX_HUMAN

  • Pathway: Polyol metabolism; myo-inositol degradation into D-glucuronate; D-glucuronate from myo-inositol: step 1/1.

Interacting Proteins for MIOX Gene

Gene Ontology (GO) - Biological Process for MIOX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019310 inositol catabolic process IEA,ISS --
genes like me logo Genes that share ontologies with MIOX: view

No data available for SIGNOR curated interactions for MIOX Gene

Drugs & Compounds for MIOX Gene

(5) Drugs for MIOX Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
D-Glucuronic acid Experimental Pharma 0

(7) Additional Compounds for MIOX Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
oxygen
  • Dioxygen
  • Molecular oxygen
  • O2
  • Oxygen
  • Oxygen molecule
7782-44-7
Fe2+
  • Armco iron
  • Carbonyl iron
  • FE
  • Ferrovac e
  • Hematite
15438-31-0
Myoinositol
  • cis-1,2,3,5-trans-4,6-Cyclohexanehexol
  • i-Inositol
  • Iso-Inositol
  • Meat sugar
  • Meso-Inositol
87-89-8
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with MIOX: view

Transcripts for MIOX Gene

Unigene Clusters for MIOX Gene

Myo-inositol oxygenase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MIOX Gene

No ASD Table

Relevant External Links for MIOX Gene

GeneLoc Exon Structure for
MIOX
ECgene alternative splicing isoforms for
MIOX

Expression for MIOX Gene

mRNA expression in normal human tissues for MIOX Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MIOX Gene

This gene is overexpressed in Kidney - Cortex (x50.8).

Protein differential expression in normal tissues from HIPED for MIOX Gene

This gene is overexpressed in Kidney (68.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MIOX Gene



SOURCE GeneReport for Unigene cluster for MIOX Gene Hs.129227

mRNA Expression by UniProt/SwissProt for MIOX Gene

Q9UGB7-MIOX_HUMAN
Tissue specificity: Kidney specific.
genes like me logo Genes that share expression patterns with MIOX: view

Protein tissue co-expression partners for MIOX Gene

- Elite partner

Primer Products

Orthologs for MIOX Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MIOX Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MIOX 35
  • 87.72 (n)
  • 86.67 (a)
MIOX 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MIOX 35
  • 86.78 (n)
  • 88.77 (a)
MIOX 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Miox 35
  • 86.08 (n)
  • 89.82 (a)
Miox 16
Miox 36
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Miox 35
  • 85.5 (n)
  • 90.53 (a)
oppossum
(Monodelphis domestica)
Mammalia MIOX 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MIOX 36
  • 70 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MIOX 36
  • 100 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia miox 35
  • 66.67 (n)
  • 70.5 (a)
zebrafish
(Danio rerio)
Actinopterygii miox 35
  • 68.82 (n)
  • 67.63 (a)
miox 36
  • 67 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9888 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003636 35
  • 61.78 (n)
  • 58.97 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6910 35
  • 62.42 (n)
  • 57.09 (a)
CG6910 36
  • 53 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C54E4.5 35
  • 57.38 (n)
  • 51.91 (a)
C54E4.5 36
  • 50 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR482W 35
  • 51.84 (n)
  • 44.49 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E10737g 35
  • 49.93 (n)
  • 45.88 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons MIOX1 35
  • 55.04 (n)
  • 48.06 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.6304 35
barley
(Hordeum vulgare)
Liliopsida Hv.1000 35
rice
(Oryza sativa)
Liliopsida Os.6345 35
Os06g0561000 35
  • 62.13 (n)
  • 50.19 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.2631 35
corn
(Zea mays)
Liliopsida Zm.16227 35
bread mold
(Neurospora crassa)
Ascomycetes NCU08856 35
  • 52.64 (n)
  • 44.4 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.33 36
  • 57 (a)
OneToOne
Species with no ortholog for MIOX:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for MIOX Gene

ENSEMBL:
Gene Tree for MIOX (if available)
TreeFam:
Gene Tree for MIOX (if available)

Paralogs for MIOX Gene

Pseudogenes.org Pseudogenes for MIOX Gene

genes like me logo Genes that share paralogs with MIOX: view

No data available for Paralogs for MIOX Gene

Variants for MIOX Gene

Sequence variations from dbSNP and Humsavar for MIOX Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs2232875 -- 50,486,963(+) CTGGT(A/G)GCCAG intron-variant, upstream-variant-2KB
rs2232876 -- 50,486,976(+) ACTCC(C/T)GCCCT intron-variant, upstream-variant-2KB
rs2232877 -- 50,487,038(+) CAGCG(G/T)CTGCC intron-variant, upstream-variant-2KB
rs2232878 -- 50,487,243(+) TGGCG(C/T)GGGAG intron-variant, upstream-variant-2KB
rs2232879 -- 50,487,342(+) GTGGA(A/G)CTGAC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIOX Gene

Variant ID Type Subtype PubMed ID
nsv915495 CNV Loss 21882294
nsv914525 CNV Loss 21882294
dgv5062n71 CNV Loss 21882294
nsv834238 CNV Loss 17160897
dgv5063n71 CNV Loss 21882294
nsv914541 CNV Loss 21882294
nsv471224 CNV Loss 18288195
nsv914542 CNV Loss 21882294
nsv914543 CNV Loss 21882294
nsv829338 CNV Gain 20364138
nsv914544 CNV Loss 21882294
nsv3669 CNV Insertion 18451855
dgv5064n71 CNV Loss 21882294
dgv5065n71 CNV Loss 21882294
nsv834239 CNV Loss 17160897

Variation tolerance for MIOX Gene

Residual Variation Intolerance Score: 90.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.16; 39.24% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for MIOX Gene

Disorders for MIOX Gene

Relevant External Links for MIOX

Genetic Association Database (GAD)
MIOX
Human Genome Epidemiology (HuGE) Navigator
MIOX
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIOX

No disorders were found for MIOX Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIOX Gene

Publications for MIOX Gene

  1. Identification of a renal-specific oxido-reductase in newborn diabetic mice. (PMID: 10944187) Yang Q. … Kanwar Y.S. (Proc. Natl. Acad. Sci. U.S.A. 2000) 2 3 4 67
  2. Structural and biophysical characterization of human myo-inositol oxygenase. (PMID: 18364358) Thorsell A.G. … Hallberg B.M. (J. Biol. Chem. 2008) 3 23
  3. Up-regulation of human myo-inositol oxygenase by hyperosmotic stress in renal proximal tubular epithelial cells. (PMID: 15778219) Prabhu K.S. … Reddy C.C. (J. Biol. Chem. 2005) 3 23
  4. Molecular cloning, expression, and characterization of myo-inositol oxygenase from mouse, rat, and human kidney. (PMID: 15504367) Arner R.J. … Reddy C.C. (Biochem. Biophys. Res. Commun. 2004) 3 23
  5. myo-Inositol oxygenase: molecular cloning and expression of a unique enzyme that oxidizes myo-inositol and D-chiro-inositol. (PMID: 11716759) Arner R.J. … Reddy C.C. (Biochem. J. 2001) 2 3

Products for MIOX Gene

Sources for MIOX Gene

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