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MIOX Gene

protein-coding   GIFtS: 54
GCID: GC22P050925

Myo-Inositol Oxygenase

(Previous name: aldehyde reductase (aldose reductase) like 6)
(Previous symbol: ALDRL6)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Myo-Inositol Oxygenase1 2 3     MI Oxygenase2 3
ALDRL61 2 3     EC 1.13.99.13 8
Kidney-Specific Protein 321 2 3     Inositol Oxygenase2
Aldehyde Reductase (Aldose Reductase) Like 61 2     KSP323
Aldehyde Reductase-Like 62 3     RSOR3
Renal-Specific Oxidoreductase2 3     

External Ids:    HGNC: 145221   Entrez Gene: 555862   Ensembl: ENSG000001002537   OMIM: 6067745   UniProtKB: Q9UGB73   

Export aliases for MIOX gene to outside databases

Previous GC identifers: GC22P049216 GC22P049272 GC22P033815


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MIOX Gene:
MIOX (myo-inositol oxygenase) is a protein-coding gene. Diseases associated with MIOX include whipple disease, and type 1 diabetes mellitus. GO annotations related to this gene include aldo-keto reductase (NADP) activity and NADP binding.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000022.11  NT_011526.8  NC_018933.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MIOX gene promoter:
         Egr-3   RP58   Elk-1   RelA   AP-2gamma   C/EBPalpha   AP-2beta   ARP-1   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMIOX promoter sequence
   Search Chromatin IP Primers for MIOX

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MIOX


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.3   Ensembl cytogenetic band:  22q13.33   HGNC cytogenetic band: 22q13.3

MIOX Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MIOX gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P050925:  view genomic region     (about GC identifiers)

Start:
50,925,213 bp from pter      End:
50,929,077 bp from pter
Size:
3,865 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MIOX_HUMAN, Q9UGB7 (See protein sequence)
Recommended Name: Inositol oxygenase  
Size: 285 amino acids; 33010 Da
Cofactor: Binds 2 iron ions per subunit
1 PDB 3D structure from and Proteopedia for MIOX:
2IBN (3D)    
Secondary accessions: Q05DJ6 Q5S8C9 Q9BZZ1 Q9UHB8
Alternative splicing: 2 isoforms:  Q9UGB7-1   Q9UGB7-2   

Explore the universe of human proteins at neXtProt for MIOX: NX_Q9UGB7

Explore proteomics data for MIOX at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for MIOX (Q9UGB7) (see all 9)
     HDLGKVL  TYKLMHT  HPDKDWF  EFNKFDLY 


    See MIOX Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060054.4  
    ENSEMBL proteins: 
     ENSP00000379082   ENSP00000216075   ENSP00000379081   ENSP00000409894  

    MIOX Human Recombinant Protein Products:

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    GenScript Custom Purified and Recombinant Proteins Services for MIOX
    Novus Biologicals MIOX Protein
    Novus Biologicals MIOX Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MIOX

    MIOX Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Novus Biologicals MIOX Antibodies
    Abcam antibodies for MIOX
    Cloud-Clone Corp. Antibodies for MIOX
    ThermoFisher Antibody for MIOX
    LSBio Antibodies in human, mouse, rat for MIOX

    MIOX Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for MIOX
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MIOX
    Cloud-Clone Corp. CLIAs for MIOX


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR007828 Inositol_oxygenase

    Graphical View of Domain Structure for InterPro Entry Q9UGB7

    ProtoNet protein and cluster: Q9UGB7

    1 Blocks protein domain: IPB007828 Protein of unknown function DUF706

    UniProtKB/Swiss-Prot: MIOX_HUMAN, Q9UGB7
    Similarity: Belongs to the myo-inositol oxygenase family


    MIOX for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MIOX_HUMAN, Q9UGB7
    Catalytic activity: Myo-inositol + O(2) = D-glucuronate + H(2)O

         Enzyme Number (IUBMB): EC 1.13.99.11 2

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004033aldo-keto reductase (NADP) activity ISS--
    GO:0005506iron ion binding ----
    GO:0008199ferric iron binding IDA18364358
    GO:0016651oxidoreductase activity, acting on NAD(P)H IEA--
    GO:0016701oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ISS--
         
    MIOX for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for MIOX:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MIOX
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MIOX

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MIOX
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MIOX

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat MIOX using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate MIOX
    SwitchGear 3'UTR luciferase reporter plasmidMIOX 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MIOX
    Predesigned siRNA for gene silencing in human, mouse, rat MIOX

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MIOX

    Clone
    Products:
         
    OriGene clones in human, mouse for MIOX (see all 6)
    OriGene ORF clones in mouse, rat for MIOX
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MIOX (NM_017584)
    Sino Biological Human cDNA Clone for MIOX
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MIOX
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MIOX

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for MIOX
    Browse ESI BIO Cell Lines and PureStem Progenitors for MIOX 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MIOX


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MIOX_HUMAN, Q9UGB7: Cytoplasm (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus2
    extracellular1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ISS--
    GO:0016234inclusion body ISS--

    MIOX for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MIOX About    
    See pathways by source

    SuperPathContained pathways About
    1Inositol phosphate metabolism (KEGG)
    Inositol phosphate metabolism0.61
    2Glucuronidation
    Ascorbate and aldarate metabolism0.61

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    2 Kegg Pathways  (Kegg details for MIOX):
        Ascorbate and aldarate metabolism
    Inositol phosphate metabolism

    UniProtKB/Swiss-Prot: MIOX_HUMAN, Q9UGB7
    Pathway: Polyol metabolism; myo-inositol degradation into D-glucuronate; D-glucuronate from myo-inositol: step 1/1


    MIOX for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MIOX: 

              Cell Lineage Identification in human mouse rat
              Terminal Differentiation Markers in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for MIOX

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    Selected Interacting proteins for MIOX (Q9UGB73 ENSP000002160754) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LIX1LQ8IVB53I2D: score=5 
    GLI2P100703I2D: score=4 
    IMPA1ENSP000004085264STRING: ENSP00000408526
    IMPA2ENSP000002691594STRING: ENSP00000269159
    GUSBENSP000003027284STRING: ENSP00000302728
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0019310inositol catabolic process ISS--
    GO:0055114oxidation-reduction process ----

    MIOX for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MIOX

    5 HMDB Compounds for MIOX    About this table
    CompoundSynonyms CAS #PubMed Ids
    D-Glucuronic acidD-(+)-glucuronate (see all 15)6556-12-3--
    IronArmco iron (see all 19)7439-89-6--
    MyoinositolMI (see all 11)87-89-8--
    OxygenOxygen (see all 5)7782-44-7--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    9 Novoseek inferred chemical compound relationships for MIOX gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hematite 95.3 75 15778219 (6), 16332355 (6), 15504367 (6), 19091876 (5) (see all 15)
    inositol 84.4 96 15778219 (4), 19091876 (4), 17012379 (3), 14976233 (2) (see all 15)
    glucuronic acid 82.6 16 18364358 (1), 16634621 (1), 16895396 (1), 16634620 (1) (see all 6)
    d-glucuronic acid 77.6 6 15778219 (1), 15504367 (1)
    glycol 72.6 2 16634621 (1), 16606846 (1)
    ascorbic acid 41.5 13 19091876 (4), 14976233 (1), 16634620 (1)
    iron 41.4 4 15504367 (1), 16634620 (1)
    mannitol 33.1 2 15778219 (1)
    oxygen 1.42 3 16634621 (1), 16634620 (1)



    MIOX for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MIOX gene: 
    NM_017584.5  

    Unigene Cluster for MIOX:

    Myo-inositol oxygenase
    Hs.129227  [show with all ESTs]
    Unigene Representative Sequence: BC064395
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000395733 ENST00000216075 ENST00000395732(uc003bll.1 uc003blm.1 uc003bln.1)
    ENST00000451761
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MIOX using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate MIOX
    SwitchGear 3'UTR luciferase reporter plasmidMIOX 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MIOX
    Predesigned siRNA for gene silencing in human, mouse, rat MIOX
    Clone
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    OriGene clones in human, mouse for MIOX (see all 6)
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MIOX (NM_017584)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MIOX
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MIOX
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for MIOX
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MIOX
      QuantiTect SYBR Green Assays in human, mouse, rat MIOX
      QuantiFast Probe-based Assays in human, mouse, rat MIOX

    Additional mRNA sequence: 

    AF197129.1 AY064416.1 AY738258.1 BC012025.1 BC064395.1 BC073848.1 CR456478.1 

    4 DOTS entries:

    DT.91944039  DT.95372501  DT.86854821  DT.424241 

    Selected AceView cDNA sequences (see all 82):

    BF222464 BI850744 AY064416 AI580280 BC012025 AI478354 AI949898 NM_017584 
    BF868686 CA424408 BI517625 CR456478 BC064395 BX280539 BI759437 AI636246 
    BC073848 BM924395 BQ330382 AI792051 AI758936 AW015026 AI768500 AI767537 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MIOX expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGCCCTGGG
    MIOX Expression
    About this image


    MIOX expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Ovary (Reproductive System)
             Secondary follicles
     
     Liver (Hepatobiliary System)
     
     Kidney (Urinary System)
    MIOX Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MIOX Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.129227

    UniProtKB/Swiss-Prot: MIOX_HUMAN, Q9UGB7
    Tissue specificity: Kidney specific

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MIOX: 
              Cell Lineage Identification in human mouse rat
              Terminal Differentiation Markers in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for MIOX
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MIOX
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MIOX

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MIOX gene from Selected species (see all 24)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Miox1 , 5 myo-inositol oxygenase1, 5 86.08(n)1
    89.82(a)1
      15 (44.82 cM)5
    567271  NM_019977.21  NP_064361.21 
     893343985 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia miox1 myo-inositol oxygenase 66.67(n)
    70.5(a)
      496668  XM_002939372.2  XP_002939418.2 
    zebrafish
    (Danio rerio)
    Actinopterygii miox1 myo-inositol oxygenase 68.82(n)
    67.63(a)
      571850  NM_001030266.1  NP_001025437.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG69101 CG6910 62.42(n)
    57.09(a)
      39391  NM_140299.3  NP_648556.3 
    worm
    (Caenorhabditis elegans)
    Secernentea C54E4.51 C54E4.5 57.38(n)
    51.91(a)
      183790  NM_067769.3  NP_500170.3 
    A. gossypii yeast
    (Ashbya gossypii)
    Saccharomycetes AGOS_AFR482W1 AGOS_AFR482W 51.84(n)
    44.49(a)
      4622308  NM_212165.1  NP_986029.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons MIOX11 MIOX1 55.04(n)
    48.06(a)
      838014  NM_101319.3  NP_172904.2 
    rice
    (Oryza sativa)
    Liliopsida Os.63452 Oryza sativa (japonica cultivar-group) cDNA clone0 more 82.24(n)    AK103977.1 


    ENSEMBL Gene Tree for MIOX (if available)
    TreeFam Gene Tree for MIOX (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MIOX gene

    MIOX for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for MIOX
    PGOHUM00000249420


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MIOX (see all 258)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs563742811,2
    C--50925367(+) CAGAG-/AGGCTCT 1 -- int10--------
    rs22328751,2
    C,F--50925392(+) CTGGTG/AGCCAG 1 -- int12Minor allele frequency- A:0.02NA EU 949
    rs22328761,2
    C,F,A,H--50925405(+) ACTCCC/TGCCCT 1 -- int17Minor allele frequency- T:0.31NA CSA WA EA 366
    rs1459248231,2
    C--50925433(+) CCAGC-/CCTCCTCC 1 -- int10--------
    rs105388661,2
    C--50925443(+) CCTCC-/TCCGTCCA 2 -- int1 cds10--------
    rs22328771,2
    C,F--50925467(+) CAGCGG/TCTGCC 1 -- int10--------
    rs22328781,2
    C,H--50925672(+) TGGCGC/TGGGAG 1 -- int111Minor allele frequency- T:0.05NA WA CSA 255
    rs1843160011,2
    C--50925765(+) TTCCTC/TGTGGA 1 -- int10--------
    rs22328791,2
    C,F,H--50925771(+) GTGGAG/ACTGAC 1 -- int117Minor allele frequency- A:0.12NS NA CSA WA EU 2467
    rs1511513501,2
    C--50925884(+) CTTCCG/AGAACT 2 /Q /R mis11Minor allele frequency- A:0.00NA 4542

    HapMap Linkage Disequilibrium report for MIOX (50925213 - 50929077 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for MIOX (see all 15):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv3669CNV Insertion18451855
    nsv914541CNV Loss21882294
    nsv915495CNV Loss21882294
    dgv5065n71CNV Loss21882294
    nsv914544CNV Loss21882294
    dgv5062n71CNV Loss21882294
    nsv834238CNV Loss17160897
    dgv5064n71CNV Loss21882294
    nsv914543CNV Loss21882294
    nsv914525CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MIOX
    DNA2.0 Custom Variant and Variant Library Synthesis for MIOX

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606774    OMIM disorders: --

    5 diseases for MIOX:    
    About MalaCards
    whipple disease    type 1 diabetes mellitus    type 1 diabetes    diabetes mellitus
    malaria


    MIOX for disorders           About GeneDecksing

    Genetic Association Database (GAD): MIOX
    Human Genome Epidemiology (HuGE) Navigator: MIOX (1 document)

    Export disorders for MIOX gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MIOX gene, integrated from 10 sources (see all 28):
    (articles sorted by number of sources associating them with MIOX)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a renal-specific oxido-reductase in newborn diabetic mice. (PubMed id 10944187)1, 2, 3 Yang Q....Kanwar Y.S. (Proc. Natl. Acad. Sci. U.S.A. 2000)
    2. Molecular cloning, expression, and characterization of myo-inositol oxygenase from mouse, rat, and human kidney. (PubMed id 15504367)1, 2, 9 Arner R.J.... Reddy C.C. (Biochem. Biophys. Res. Commun. 2004)
    3. Structural and biophysical characterization of human myo-inositol oxygenase. (PubMed id 18364358)1, 2, 9 Thorsell A.G.... Hallberg B.M. (J. Biol. Chem. 2008)
    4. Polymorphisms of myo-inositol oxygenase gene are associated with Type 1 diabetes mellitus. (PubMed id 19896870)1, 4 Yang B....Demaine A.G. (J. Diabetes Complicat. 2010)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (Genome Biol. 2004)
    8. myo-Inositol oxygenase: molecular cloning and expression of a unique enzyme that oxidizes myo-inositol and D-chiro-inositol. (PubMed id 11716759)1, 3 Arner R.J....Reddy C.C. (Biochem. J. 2001)
    9. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I.... Wright H. (Nature 1999)
    10. Up-regulation of human myo-inositol oxygenase by hyperosmotic stress in renal proximal tubular epithelial cells. (PubMed id 15778219)1, 9 Prabhu K.S....Reddy C.C. (J. Biol. Chem. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
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      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55586 HGNC: 14522 AceView: ALDRL6 Ensembl:ENSG00000100253 euGenes: HUgn55586
    ECgene: MIOX Kegg: 55586 H-InvDB: MIOX

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MIOX Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MIOX gene:
    Search GeneIP for patents involving MIOX

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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