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Aliases for MIOX Gene

Aliases for MIOX Gene

  • Myo-Inositol Oxygenase 2 3 4 5
  • Kidney-Specific Protein 32 2 3 4
  • Aldehyde Reductase (Aldose Reductase) Like 6 2 3
  • Renal-Specific Oxidoreductase 3 4
  • Aldehyde Reductase-Like 6 3 4
  • MI Oxygenase 3 4
  • EC 4 61
  • ALDRL6 3 4
  • Inositol Oxygenase 3
  • KSP32 4
  • RSOR 4

External Ids for MIOX Gene

Previous HGNC Symbols for MIOX Gene

  • ALDRL6

Previous GeneCards Identifiers for MIOX Gene

  • GC22P049216
  • GC22P049272
  • GC22P050925
  • GC22P033815

Summaries for MIOX Gene

GeneCards Summary for MIOX Gene

MIOX (Myo-Inositol Oxygenase) is a Protein Coding gene. Among its related pathways are Inositol phosphate metabolism (KEGG) and Porphyrin and chlorophyll metabolism. GO annotations related to this gene include iron ion binding and oxidoreductase activity, acting on NAD(P)H.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIOX Gene

Genomics for MIOX Gene

Regulatory Elements for MIOX Gene

Enhancers for MIOX Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22F050398 1.3 FANTOM5 Ensembl ENCODE 11.8 -84.3 -84301 2.4 CTCF USF1 SAP130 ARID4B MAX ZIC2 RAD21 YY1 HNF4G SMC3 TYMP ODF3B MIOX PIM3 PLXNB2 TRABD CHKB SCO2 HDAC10 GC22P050399
GH22F050451 0.9 FANTOM5 ENCODE 16.7 -31.3 -31256 1.7 ZNF324 ZNF362 JUND PATZ1 ZEB2 ZBTB20 MIOX DENND6B TUBGCP6 CHKB PPP6R2 SBF1 NCAPH2 MOV10L1 HDAC10 GC22P050436
GH22F050505 1.1 ENCODE 12.1 +23.9 23866 4.2 PKNOX1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 SP3 SYCE3 LMF2 TYMP MIOX LOC105377205 ARSA ENSG00000272940 NCAPH2
GH22F050396 1 ENCODE 11.8 -86.9 -86921 1.1 ATF1 MLX ARID4B DMAP1 ZNF263 SP5 NFYC ZHX2 MIER2 PPARG MIOX PPP6R2 GC22P050399 GC22P050372
GH22F050443 0.8 ENCODE 12.6 -39.0 -39026 2.5 KLF1 ZEB1 HIC1 GLIS2 POLR2A PATZ1 SCRT2 ZBTB10 SCRT1 PAF1 PLXNB2 ADM2 SBF1 MIOX MAPK8IP2 CHKB SYCE3 PPP6R2 GC22P050436 GC22P050437
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIOX on UCSC Golden Path with GeneCards custom track

Promoters for MIOX Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000620254 -1988 1601 DRAP1 KLF1 USF1 SAP130 CEBPG EGR1 POLR2A EZH2 GATAD2A MAZ

Genomic Location for MIOX Gene

50,483,988 bp from pter
50,490,648 bp from pter
6,661 bases
Plus strand

Genomic View for MIOX Gene

Genes around MIOX on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIOX Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIOX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIOX Gene

Proteins for MIOX Gene

  • Protein details for MIOX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Inositol oxygenase
    Protein Accession:
    Secondary Accessions:
    • Q05DJ6
    • Q5S8C9
    • Q9BZZ1
    • Q9UHB8

    Protein attributes for MIOX Gene

    285 amino acids
    Molecular mass:
    33010 Da
    Name=Fe cation; Xref=ChEBI:CHEBI:24875;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for MIOX Gene

    Alternative splice isoforms for MIOX Gene


neXtProt entry for MIOX Gene

Selected DME Specific Peptides for MIOX Gene


Post-translational modifications for MIOX Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MIOX Gene

Domains & Families for MIOX Gene

Protein Domains for MIOX Gene

Suggested Antigen Peptide Sequences for MIOX Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the myo-inositol oxygenase family.
  • Belongs to the myo-inositol oxygenase family.
genes like me logo Genes that share domains with MIOX: view

No data available for Gene Families for MIOX Gene

Function for MIOX Gene

Molecular function for MIOX Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Myo-inositol + O(2) = D-glucuronate + H(2)O.

Enzyme Numbers (IUBMB) for MIOX Gene

Gene Ontology (GO) - Molecular Function for MIOX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004033 aldo-keto reductase (NADP) activity ISS --
GO:0005506 iron ion binding IEA --
GO:0008199 ferric iron binding IDA 18364358
GO:0016491 oxidoreductase activity IEA --
GO:0016651 oxidoreductase activity, acting on NAD(P)H IEA --
genes like me logo Genes that share ontologies with MIOX: view
genes like me logo Genes that share phenotypes with MIOX: view

Animal Model Products

  • Taconic Biosciences Mouse Models for MIOX

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MIOX Gene

Localization for MIOX Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIOX Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIOX gene
Compartment Confidence
extracellular 5
cytosol 4
nucleus 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for MIOX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,ISS --
GO:0016234 inclusion body ISS --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with MIOX: view

Pathways & Interactions for MIOX Gene

genes like me logo Genes that share pathways with MIOX: view

Pathways by source for MIOX Gene

UniProtKB/Swiss-Prot Q9UGB7-MIOX_HUMAN

  • Pathway: Polyol metabolism; myo-inositol degradation into D-glucuronate; D-glucuronate from myo-inositol: step 1/1.

Interacting Proteins for MIOX Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 7)
Selected Interacting proteins: ENSP00000216075 Q9UGB7-MIOX_HUMAN for MIOX Gene via STRING IID

Gene Ontology (GO) - Biological Process for MIOX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019310 inositol catabolic process IEA,ISS --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with MIOX: view

No data available for SIGNOR curated interactions for MIOX Gene

Drugs & Compounds for MIOX Gene

(7) Drugs for MIOX Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Oxygen Approved, Vet_approved Pharma 0
Water Approved Pharma 0
D-Glucuronic acid Experimental Pharma 0

(5) Additional Compounds for MIOX Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Armco iron
  • Carbonyl iron
  • FE
  • Ferrovac e
  • Hematite
  • cis-1,2,3,5-trans-4,6-Cyclohexanehexol
  • i-Inositol
  • Iso-Inositol
  • Meat sugar
  • Meso-Inositol
genes like me logo Genes that share compounds with MIOX: view

Transcripts for MIOX Gene

Unigene Clusters for MIOX Gene

Myo-inositol oxygenase:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIOX Gene

No ASD Table

Relevant External Links for MIOX Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIOX Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIOX Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MIOX Gene

This gene is overexpressed in Kidney - Cortex (x50.8).

Protein differential expression in normal tissues from HIPED for MIOX Gene

This gene is overexpressed in Kidney (68.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MIOX Gene

Protein tissue co-expression partners for MIOX Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MIOX Gene:


SOURCE GeneReport for Unigene cluster for MIOX Gene:


mRNA Expression by UniProt/SwissProt for MIOX Gene:

Tissue specificity: Kidney specific.
genes like me logo Genes that share expression patterns with MIOX: view

Primer Products

Orthologs for MIOX Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MIOX Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MIOX 35
  • 100 (a)
(Bos Taurus)
Mammalia MIOX 34 35
  • 87.72 (n)
(Canis familiaris)
Mammalia MIOX 34 35
  • 86.78 (n)
(Mus musculus)
Mammalia Miox 34 16 35
  • 86.08 (n)
(Rattus norvegicus)
Mammalia Miox 34
  • 85.5 (n)
(Monodelphis domestica)
Mammalia MIOX 35
  • 85 (a)
(Ornithorhynchus anatinus)
Mammalia MIOX 35
  • 70 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia miox 34
  • 66.67 (n)
(Danio rerio)
Actinopterygii miox 34 35
  • 68.82 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9888 34
fruit fly
(Drosophila melanogaster)
Insecta CG6910 34 35
  • 62.42 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003636 34
  • 61.78 (n)
(Caenorhabditis elegans)
Secernentea C54E4.5 34 35
  • 57.38 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR482W 34
  • 51.84 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E10737g 34
  • 49.93 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons MIOX1 34
  • 55.04 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.6304 34
(Oryza sativa)
Liliopsida Os06g0561000 34
  • 62.13 (n)
Os.6345 34
(Hordeum vulgare)
Liliopsida Hv.1000 34
(Triticum aestivum)
Liliopsida Ta.2631 34
(Zea mays)
Liliopsida Zm.16227 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.33 35
  • 57 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU08856 34
  • 52.64 (n)
Species where no ortholog for MIOX was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for MIOX Gene

Gene Tree for MIOX (if available)
Gene Tree for MIOX (if available)

Paralogs for MIOX Gene Pseudogenes for MIOX Gene

genes like me logo Genes that share paralogs with MIOX: view

No data available for Paralogs for MIOX Gene

Variants for MIOX Gene

Sequence variations from dbSNP and Humsavar for MIOX Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs1055271 -- 50,489,911(+) GCCTG(C/G)AGAGG nc-transcript-variant, utr-variant-3-prime
rs1055272 -- 50,489,913(+) CTGGA(A/G)AGGCC nc-transcript-variant, utr-variant-3-prime
rs1064043 -- 50,490,015(+) CCTGG(C/G)GTCAA nc-transcript-variant, utr-variant-3-prime
rs111414974 -- 50,488,736(+) CACGG(-/C)CCCCC intron-variant, reference, frameshift-variant
rs111581490 -- 50,483,956(+) GAAAG(G/T)GCTCC upstream-variant-2KB, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MIOX Gene

Variant ID Type Subtype PubMed ID
nsv1057656 CNV gain 25217958
nsv1073179 CNV deletion 25765185
nsv1160782 CNV deletion 26073780
nsv3669 CNV insertion 18451855
nsv471224 CNV loss 18288195
nsv829338 CNV gain 20364138
nsv834238 CNV loss 17160897
nsv834239 CNV loss 17160897
nsv955201 CNV deletion 24416366

Variation tolerance for MIOX Gene

Residual Variation Intolerance Score: 90.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.16; 39.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MIOX Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MIOX Gene

Disorders for MIOX Gene

Relevant External Links for MIOX

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MIOX Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIOX Gene

Publications for MIOX Gene

  1. Structural and biophysical characterization of human myo-inositol oxygenase. (PMID: 18364358) Thorsell A.G. … Hallberg B.M. (J. Biol. Chem. 2008) 3 4 22 64
  2. Molecular cloning, expression, and characterization of myo-inositol oxygenase from mouse, rat, and human kidney. (PMID: 15504367) Arner R.J. … Reddy C.C. (Biochem. Biophys. Res. Commun. 2004) 3 4 22 64
  3. Identification of a renal-specific oxido-reductase in newborn diabetic mice. (PMID: 10944187) Yang Q. … Kanwar Y.S. (Proc. Natl. Acad. Sci. U.S.A. 2000) 2 3 4 64
  4. Polymorphisms of myo-inositol oxygenase gene are associated with Type 1 diabetes mellitus. (PMID: 19896870) Yang B. … Demaine A.G. (J. Diabetes Complicat. 2010) 3 46 64
  5. Up-regulation of human myo-inositol oxygenase by hyperosmotic stress in renal proximal tubular epithelial cells. (PMID: 15778219) Prabhu K.S. … Reddy C.C. (J. Biol. Chem. 2005) 3 22 64

Products for MIOX Gene

Sources for MIOX Gene

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