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Aliases for MIOS Gene

Aliases for MIOS Gene

  • Missing Oocyte, Meiosis Regulator, Homolog (Drosophila) 2 3
  • WD Repeat-Containing Protein Mio 2 3
  • WUGSC:H_DJ1159O04.1 3
  • H_DJ1159O04.1 3

External Ids for MIOS Gene

Summaries for MIOS Gene

GeneCards Summary for MIOS Gene

MIOS (Missing Oocyte, Meiosis Regulator, Homolog (Drosophila)) is a Protein Coding gene.

UniProtKB/Swiss-Prot for MIOS Gene

  • As a component of the GATOR2 complex, inhibits GATOR1 complex, an inhibitor of the amino acid-sensing branch of the TORC1 pathway

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIOS Gene

Genomics for MIOS Gene

Genomic Location for MIOS Gene

Start:
7,566,872 bp from pter
End:
7,608,929 bp from pter
Size:
42,058 bases
Orientation:
Plus strand

Genomic View for MIOS Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIOS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIOS Gene

Proteins for MIOS Gene

  • Protein details for MIOS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NXC5-MIO_HUMAN
    Recommended name:
    WD repeat-containing protein mio
    Protein Accession:
    Q9NXC5
    Secondary Accessions:
    • B2RTV6
    • O75216
    • Q7L551
    • Q9H092

    Protein attributes for MIOS Gene

    Size:
    875 amino acids
    Molecular mass:
    98584 Da
    Quaternary structure:
    • Within the GATOR complex, component of the GATOR2 subcomplex, made of MIOS, SEC13, SEH1L, WDR24 and WDR59. The GATOR complex strongly interacts with RRAGA/RRAGC and RRAGB/RRAGC heterodimers.

    Alternative splice isoforms for MIOS Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MIOS Gene

Proteomics data for MIOS Gene at MOPED

Post-translational modifications for MIOS Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys479

Other Protein References for MIOS Gene

No data available for DME Specific Peptides for MIOS Gene

Domains for MIOS Gene

Protein Domains for MIOS Gene

UniProtKB/Swiss-Prot:

MIO_HUMAN
Family:
  • Belongs to the WD repeat mio family.:
    • Q9NXC5
Similarity:
  • Contains 6 WD repeats.:
    • Q9NXC5
genes like me logo Genes that share domains with MIOS: view

No data available for Gene Families for MIOS Gene

Function for MIOS Gene

Molecular function for MIOS Gene

UniProtKB/Swiss-Prot Function: As a component of the GATOR2 complex, inhibits GATOR1 complex, an inhibitor of the amino acid-sensing branch of the TORC1 pathway

Gene Ontology (GO) - Molecular Function for MIOS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with MIOS: view

miRNA for MIOS Gene

miRTarBase miRNAs that target MIOS

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for MIOS Gene

Localization for MIOS Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MIOS Gene COMPARTMENTS Subcellular localization image for MIOS gene
Compartment Confidence
cytosol 2
nucleus 2
lysosome 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for MIOS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005765 lysosomal membrane IDA 17897319
GO:0030054 cell junction IDA --
genes like me logo Genes that share ontologies with MIOS: view

Pathways for MIOS Gene

SuperPathways for MIOS Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIOS Gene

None

No data available for Pathways by source for MIOS Gene

Transcripts for MIOS Gene

Unigene Clusters for MIOS Gene

Missing oocyte, meiosis regulator, homolog (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MIOS Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d · 4e ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b
SP1: - - -
SP2:
SP3: - -
SP4:
SP5: - - -
SP6: - -
SP7:

Relevant External Links for MIOS Gene

GeneLoc Exon Structure for
MIOS
ECgene alternative splicing isoforms for
MIOS

Expression for MIOS Gene

mRNA expression in normal human tissues for MIOS Gene

mRNA differential expression in normal tissues according to GTEx for MIOS Gene

This gene is overexpressed in Muscle - Skeletal (7.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MIOS Gene

SOURCE GeneReport for Unigene cluster for MIOS Gene Hs.520215

genes like me logo Genes that share expressions with MIOS: view

Orthologs for MIOS Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MIOS Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MIOS 36
  • 99.43 (n)
  • 100 (a)
MIOS 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MIOS 36
  • 92.99 (n)
  • 98.06 (a)
MIOS 37
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MIOS 36
  • 94.1 (n)
  • 99.2 (a)
MIOS 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mios 36
  • 91.96 (n)
  • 98.17 (a)
Mios 16
Mios 37
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MIOS 37
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MIOS 37
  • 63 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mios 36
  • 92.46 (n)
  • 98.06 (a)
chicken
(Gallus gallus)
Aves MIOS 36
  • 81.69 (n)
  • 92.11 (a)
MIOS 37
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MIOS 37
  • 90 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.11478 36
tropical clawed frog
(Silurana tropicalis)
Amphibia mios 36
  • 76.47 (n)
  • 88.56 (a)
Str.1409 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12236 36
zebrafish
(Danio rerio)
Actinopterygii mios 36
  • 70.08 (n)
  • 82.76 (a)
mios 37
  • 82 (a)
OneToOne
zgc55958 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007984 36
  • 44.72 (n)
  • 37 (a)
fruit fly
(Drosophila melanogaster)
Insecta mio 36
  • 46.06 (n)
  • 36.92 (a)
mio 37
  • 33 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SEA4 37
  • 23 (a)
OneToOne
SEA4 39
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 45 (a)
OneToMany
CSA.3384 37
  • 45 (a)
OneToMany
Species with no ortholog for MIOS:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIOS Gene

ENSEMBL:
Gene Tree for MIOS (if available)
TreeFam:
Gene Tree for MIOS (if available)

Paralogs for MIOS Gene

No data available for Paralogs for MIOS Gene

Variants for MIOS Gene

Sequence variations from dbSNP and Humsavar for MIOS Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs4222 -- 7,607,056(-) TTCCC(C/T)GTTGT reference, synonymous-codon
rs1013002 -- 7,584,954(+) TTCTT(A/G)TAGTT intron-variant
rs3840622 -- 7,593,408(-) AAAAA(-/A)GAACA intron-variant
rs3840623 -- 7,583,692(-) TAATC(-/T)TTTAA intron-variant
rs3815229 -- 7,596,069(+) GAAGT(A/G)CCCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MIOS Gene

Variant ID Type Subtype PubMed ID
esv2752174 CNV Gain 17911159
dgv7158n71 CNV Gain 21882294
dgv7159n71 CNV Gain 21882294
nsv887477 CNV Gain 21882294
nsv8043 CNV Gain 18304495

Relevant External Links for MIOS Gene

HapMap Linkage Disequilibrium report
MIOS
Human Gene Mutation Database (HGMD)
MIOS

Disorders for MIOS Gene

No disorders were found for MIOS Gene.

No data available for UniProtKB/Swiss-Prot for MIOS Gene

Publications for MIOS Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. missing oocyte encodes a highly conserved nuclear protein required for the maintenance of the meiotic cycle and oocyte identity in Drosophila. (PMID: 14973288) Iida T. … Lilly M.A. (Development 2004) 2 3
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. Integral and associated lysosomal membrane proteins. (PMID: 17897319) Schroeder B. … Hasilik A. (Traffic 2007) 3
  5. Defining the human deubiquitinating enzyme interaction landscape. (PMID: 19615732) Sowa M.E. … Harper J.W. (Cell 2009) 3

Products for MIOS Gene

Sources for MIOS Gene

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