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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MIOS Gene

protein-coding   GIFtS: 43
GCID: GC07P007574

Missing Oocyte, Meiosis Regulator, Homolog (Drosophila)

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Missing Oocyte, Meiosis Regulator, Homolog (Drosophila)1 2
WD Repeat-Containing Protein Mio1 2
H_DJ1159O04.12
WUGSC:H_DJ1159O04.12

External Ids:    HGNC: 219051   Entrez Gene: 544682   Ensembl: ENSG000001646547   OMIM: 6153595   UniProtKB: Q9NXC53   

Export aliases for MIOS gene to outside databases

Previous GC identifer: GC07P007455


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for MIOS Gene: 
MIOS (missing oocyte, meiosis regulator, homolog (Drosophila)) is a protein-coding gene. Diseases associated with MIOS include gastroparesis.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NT_007819.17  NC_018918.2  NT_079592.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MIOS gene promoter:
         SREBP-1c   Tal-1beta   AP-2gamma   SREBP-1b   FOXL1   E47   SREBP-1a   AP-2beta   AP-2alpha   AP-2alphaA   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for MIOS

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MIOS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p21.3   Ensembl cytogenetic band:  7p21.3   HGNC cytogenetic band: 7p21.3

MIOS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MIOS gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P007574:  view genomic region     (about GC identifiers)

Start:
7,606,503 bp from pter      End:
7,648,560 bp from pter
Size:
42,058 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 7,653,840-7,694,325     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MIO_HUMAN, Q9NXC5 (See protein sequence)
Recommended Name: WD repeat-containing protein mio  
Size: 875 amino acids; 98584 Da
Secondary accessions: B2RTV6 O75216 Q7L551 Q9H092
Alternative splicing: 2 isoforms:  Q9NXC5-1   Q9NXC5-2   

Explore the universe of human proteins at neXtProt for MIOS: NX_Q9NXC5

Explore proteomics data for MIOS at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NXC5

  • MIOS Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MIOS Protein Expression
    REFSEQ proteins: NP_061878.3  
    ENSEMBL proteins: 
     ENSP00000339881   ENSP00000384088   ENSP00000413050   ENSP00000410752   ENSP00000407518  
     ENSP00000413489  

    Human Recombinant Protein Products for MIOS: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Protein Over-expression Lysate for MIOS
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for MIOS
    GenScript Custom Purified and Recombinant Proteins Services for MIOS
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MIOS 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005765lysosomal membrane IDA17897319

    MIOS for ontologies           About GeneDecksing



    MIOS Antibody Products: 
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    Novus Biologicals MIOS Antibody
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    Assay Products for MIOS: 
    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for MIOS 
    Cloud-Clone Corp. CLIAs for MIOS


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR001680 WD40_repeat
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry Q9NXC5

    ProtoNet protein and cluster: Q9NXC5

    1 Blocks protein domain: IPB001680 G-protein beta WD-40 repeat signature

    UniProtKB/Swiss-Prot: MIO_HUMAN, Q9NXC5
    Similarity: Belongs to the WD repeat mio family
    Similarity: Contains 6 WD repeats


    MIOS for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    MIOS for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for MIOS 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MIOS

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MIOS 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MIOS 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MIOS
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate MIOS:
    hsa-miR-593 hsa-miR-202 hsa-miR-888 hsa-miR-371-5p hsa-miR-1305
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MIOS
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MIOS

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of MIOS

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for MIOS (see all 8)
    OriGene ORF clones in mouse, rat for MIOS
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MIOS (NM_019005)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MIOS
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MIOS
    Sirion Biotech Customized lentivirus for stable overexpression of MIOS 
                         Customized lentivirus expression plasmids for stable overexpression of MIOS 

    Cell Line
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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MIOS


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MIOS

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5/84 Interacting proteins for MIOS (Q9NXC53 ENSP000003398814) via UniProtKB, MINT, STRING, and/or I2D (see all 84)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MIOS (MIO)

    Search CenterWatch for drugs/clinical trials and news about MIOS / MIO

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MIOS gene: 
    NM_019005.3  

    Unigene Cluster for MIOS:

    Missing oocyte, meiosis regulator, homolog (Drosophila)
    Hs.520215  [show with all ESTs]
    Unigene Representative Sequence: AL136892
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000340080(uc003srf.3 uc010ktp.1) ENST00000405785 ENST00000433635
    ENST00000456533 ENST00000433056 ENST00000445169 ENST00000461907 ENST00000493227(uc003srg.3 uc010ktq.3)
    ENST00000479694
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MIOS
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate MIOS:
    hsa-miR-593 hsa-miR-202 hsa-miR-888 hsa-miR-371-5p hsa-miR-1305
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MIOS
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MIOS
    Clone
    Products:
         
    OriGene clones in human, mouse for MIOS (see all 8)
    OriGene ORF clones in mouse, rat for MIOS
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MIOS (NM_019005)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MIOS
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MIOS
    Sirion Biotech Customized lentivirus for stable overexpression of MIOS 
                         Customized lentivirus expression plasmids for stable overexpression of MIOS 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for MIOS
    OriGene qSTAR qPCR primer pairs in human, mouse for MIOS
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MIOS
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MIOS
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MIOS

    Additional mRNA sequence: 

    AK294561.1 AL136892.1 BC005883.2 BC068512.1 BC140833.1 BC140834.1 

    13 DOTS entries:

    DT.415945  DT.95161181  DT.121128113  DT.100783156  DT.97810691  DT.40117393  DT.75101384  DT.100023466 
    DT.121128107  DT.121128111  DT.40311337  DT.100844431  DT.121128146 

    24/166 AceView cDNA sequences (see all 166):

    AI123551 CA772428 AA847203 BU182526 BG685105 AA906626 BQ421959 AA033696 
    AA806714 AA831394 W76427 BM727267 AI914166 W88763 BM023372 BM684587 
    BM127090 AA375271 BQ878955 CD243481 AA767044 BQ431850 AA865016 AI093432 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for MIOS (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d · 4e ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b
    SP1:                          -                                                     -                                               -                     
    SP2:                                                                                                                                                      
    SP3:                          -     -                                                                                                                     
    SP4:                                                                                                                                                      
    SP5:                          -     -     -                                                                                                               


    ECgene alternative splicing isoforms for MIOS

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MIOS expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGTTCTGTTC
    MIOS Expression
    About this image


    See MIOS Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MIOS

    SOURCE GeneReport for Unigene cluster: Hs.520215
        SABiosciences Custom PCR Arrays for MIOS
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MIOS

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for MIOS gene from 7/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mios1 , 5 missing oocyte, meiosis regulator, homolog (Drosophila)1, 5 91.96(n)1
    98.17(a)1
      6 (3.51 cM)5
    2528751  NM_145374.21  NP_663349.21 
     82092225 
    chicken
    (Gallus gallus)
    Aves MIOS1 missing oocyte, meiosis regulator, homolog (Drosophila) 81.69(n)
    92.11(a)
      420577  XM_418678.3  XP_418678.2 
    lizard
    (Anolis carolinensis)
    Reptilia MIOS6
    Uncharacterized protein
    90(a)
    1 ↔ 1
    6(23668172-23680423)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.114782 Xenopus laevis transcribed sequence with weak similarity more 80.34(n)    BX843109.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc559582 hypothetical protein MGC55958 74.81(n)   393208  BC047198.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta mio1 missing oocyte 45.54(n)
    36.36(a)
      33399  NM_134812.2  NP_608656.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SEA4(YBL104C)4 Subunit of the SEA (Seh1-associated) complex, a coatomer-related more   --   2(21293-18177) 852170  NP_009446.2 


    ENSEMBL Gene Tree for MIOS (if available)
    TreeFam Gene Tree for MIOS (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1087 SNPs in MIOS are shown (see all 1087)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs105279741,2
    C--7474387(+) TGCAC-/GT/GTGTG
    TGTGTGTGTGT
    GTGTG
    1 -- int11NA 2
    rs1153004901,2
    C,F--7604646(+) GTCACC/TTAAAA 1 -- us2k11Minor allele frequency- T:0.05WA 118
    rs9726001,2
    C,H--7604656(+) AGAAGA/GTAAGA 1 -- us2k113Minor allele frequency- G:0.03MN NA WA CSA EA 558
    rs1932667971,2
    --7604773(+) CATCTC/TCTGAG 1 -- us2k10--------
    rs1150189741,2
    F--7604844(+) ATTGAT/ACTGAG 1 -- us2k11Minor allele frequency- A:0.02WA 118
    rs786301271,2
    F--7604858(+) TTGTGT/GGGGGG 1 -- us2k11Minor allele frequency- G:0.09WA 118
    rs38238421,2
    C,F,A,H--7604913(-) TCACTC/TCAAAC 1 -- us2k127Minor allele frequency- T:0.49NS EA NA WA 2586
    rs1165473661,2
    F--7604969(+) CCTACA/GTTCTT 1 -- us2k11Minor allele frequency- G:0.02WA 118
    rs1429403151,2
    --7605083(+) GCCATC/TACCAC 1 -- us2k10--------
    rs37575331,2
    C,F,H--7605203(-) CAAAAC/GTGAGT 1 -- us2k111Minor allele frequency- G:0.17NA NS EA WA 918

    HapMap Linkage Disequilibrium report for MIOS (7606503 - 7648560 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for MIOS:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv7158n71CNV Gain21882294
    nsv8043CNV Gain18304495
    nsv887477CNV Gain21882294
    dgv7159n71CNV Gain21882294
    esv2752174CNV Gain17911159

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing MIOS
    DNA2.0 Custom Variant and Variant Library Synthesis for MIOS

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 615359    OMIM disorders: --

    2 diseases for MIOS:    About MalaCards
    gastroparesis    


    MIOS for disorders           About GeneDecksing


    Export disorders for MIOS gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MIOS gene, integrated from 9 sources (see all 19):
    (articles sorted by number of sources associating them with MIOS)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    2. missing oocyte encodes a highly conserved nuclear protein required for the maintenance of the meiotic cycle and oocyte identity in Drosophila. (PubMed id 14973288)1, 3 Iida T. and Lilly M.A. (2004)
    3. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    4. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    5. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    6. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
    7. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    8. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
    9. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (2009)
    10. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 54468 HGNC: 21905 AceView: FLJ20323 Ensembl:ENSG00000164654 euGenes: HUgn54468
    ECgene: MIOS H-InvDB: MIOS

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MIOS Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MIOS gene:
    Search GeneIP for patents involving MIOS

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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