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MIOS Gene

protein-coding   GIFtS: 47
GCID: GC07P007574

Missing Oocyte, Meiosis Regulator, Homolog (Drosophila)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Missing Oocyte, Meiosis Regulator, Homolog (Drosophila)1 2
WD Repeat-Containing Protein Mio1 2
H_DJ1159O04.12
WUGSC:H_DJ1159O04.12

External Ids:    HGNC: 219051   Entrez Gene: 544682   Ensembl: ENSG000001646547   OMIM: 6153595   UniProtKB: Q9NXC53   

Export aliases for MIOS gene to outside databases

Previous GC identifer: GC07P007455


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MIOS Gene:
MIOS (missing oocyte, meiosis regulator, homolog (Drosophila)) is a protein-coding gene. Diseases associated with MIOS include gastroparesis, and malaria.

UniProtKB/Swiss-Prot: MIO_HUMAN, Q9NXC5
Function: As a component of the GATOR2 complex, inhibits GATOR1 complex, an inhibitor of the amino acid-sensing
branch of the TORC1 pathway




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000007.14  NT_007819.18  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MIOS gene promoter:
         SREBP-1c   Tal-1beta   AP-2gamma   SREBP-1b   FOXL1   E47   SREBP-1a   AP-2beta   AP-2alpha   AP-2alphaA   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for MIOS

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MIOS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p21.3   Ensembl cytogenetic band:  7p21.3   HGNC cytogenetic band: 7p21.3

MIOS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MIOS gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P007574:  view genomic region     (about GC identifiers)

Start:
7,606,503 bp from pter      End:
7,648,560 bp from pter
Size:
42,058 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 7,653,840-7,694,325     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: MIO_HUMAN, Q9NXC5 (See protein sequence)
Recommended Name: WD repeat-containing protein mio  
Size: 875 amino acids; 98584 Da
Subunit: Within the GATOR complex, component of the GATOR2 subcomplex, made of MIOS, SEC13, SEH1L, WDR24 and
WDR59. The GATOR complex strongly interacts with RRAGA/RRAGC and RRAGB/RRAGC heterodimers
Secondary accessions: B2RTV6 O75216 Q7L551 Q9H092
Alternative splicing: 2 isoforms:  Q9NXC5-1   Q9NXC5-2   

Explore the universe of human proteins at neXtProt for MIOS: NX_Q9NXC5

Explore proteomics data for MIOS at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys479
  • Modification sites at PhosphoSitePlus

  • See MIOS Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_061878.3  
    ENSEMBL proteins: 
     ENSP00000339881   ENSP00000384088   ENSP00000413050   ENSP00000410752   ENSP00000407518  
     ENSP00000413489  

    MIOS Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for MIOS
    OriGene Custom MassSpec
    OriGene Custom Protein Services for MIOS
    GenScript Custom Purified and Recombinant Proteins Services for MIOS
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MIOS

    MIOS Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for MIOS
    Novus Biologicals MIOS Antibody
    Abcam antibodies for MIOS
    Cloud-Clone Corp. Antibodies for MIOS
    Search ThermoFisher Antibodies for MIOS
    Search LSBio for Antibodies for MIOS

    MIOS Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MIOS
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MIOS
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MIOS
    Cloud-Clone Corp. CLIAs for MIOS


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR001680 WD40_repeat
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry Q9NXC5

    ProtoNet protein and cluster: Q9NXC5

    1 Blocks protein domain: IPB001680 G-protein beta WD-40 repeat signature

    UniProtKB/Swiss-Prot: MIO_HUMAN, Q9NXC5
    Similarity: Belongs to the WD repeat mio family
    Similarity: Contains 6 WD repeats


    MIOS for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MIO_HUMAN, Q9NXC5
    Function: As a component of the GATOR2 complex, inhibits GATOR1 complex, an inhibitor of the amino acid-sensing
    branch of the TORC1 pathway

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    MIOS for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MIOS
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MIOS

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MIOS
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MIOS

    miRNA
    Products:
        
    miRTarBase miRNAs that target MIOS:
    hsa-mir-98-5p (MIRT027587), hsa-let-7b-5p (MIRT032301)

    Block miRNA regulation of human, mouse, rat MIOS using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate MIOS:
    hsa-miR-593 hsa-miR-202 hsa-miR-888 hsa-miR-371-5p hsa-miR-1305
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MIOS
    Predesigned siRNA for gene silencing in human, mouse, rat MIOS

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MIOS

    Clone
    Products:
         
    OriGene clones in human, mouse for MIOS (see all 7)
    OriGene ORF clones in mouse, rat for MIOS
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MIOS (NM_019005)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MIOS
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MIOS

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MIOS
    Browse ESI BIO Cell Lines and PureStem Progenitors for MIOS 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MIOS


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    lysosome1
    mitochondrion1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005765lysosomal membrane IDA17897319

    MIOS for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MIOS
    Interactions:

        Search GeneGlobe Interaction Network for MIOS

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MIOS (Q9NXC53 ENSP000003398814) via UniProtKB, MINT, STRING, and/or I2D (see all 103)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MIOS (MIO)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MIOS gene: 
    NM_019005.3  

    Unigene Cluster for MIOS:

    Missing oocyte, meiosis regulator, homolog (Drosophila)
    Hs.520215  [show with all ESTs]
    Unigene Representative Sequence: AL136892
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000340080(uc003srf.3 uc010ktp.1) ENST00000405785 ENST00000433635
    ENST00000456533 ENST00000433056 ENST00000445169 ENST00000461907 ENST00000493227(uc003srg.3 uc010ktq.3)
    ENST00000479694
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MIOS using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate MIOS:
    hsa-miR-593 hsa-miR-202 hsa-miR-888 hsa-miR-371-5p hsa-miR-1305
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MIOS
    Predesigned siRNA for gene silencing in human, mouse, rat MIOS
    Clone
    Products:
         
    OriGene clones in human, mouse for MIOS (see all 7)
    OriGene ORF clones in mouse, rat for MIOS
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MIOS (NM_019005)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MIOS
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MIOS
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for MIOS
    OriGene qSTAR qPCR primer pairs in human, mouse for MIOS
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MIOS
      QuantiTect SYBR Green Assays in human, mouse, rat MIOS
      QuantiFast Probe-based Assays in human, mouse, rat MIOS

    Additional mRNA sequence: 

    AK294561.1 AL136892.1 BC005883.2 BC068512.1 BC140833.1 BC140834.1 

    13 DOTS entries:

    DT.415945  DT.95161181  DT.121128113  DT.100783156  DT.97810691  DT.40117393  DT.75101384  DT.100023466 
    DT.121128107  DT.121128111  DT.40311337  DT.100844431  DT.121128146 

    Selected AceView cDNA sequences (see all 166):

    AI914166 BM684587 W88763 AA865016 BM023372 AA375271 BM127090 BQ431850 
    AA767044 BM727267 CD243481 BQ421959 CA772428 AA831394 W76427 AA847203 
    BQ878955 BU182526 AA906626 AI123551 AA806714 AA033696 BG685105 BG219473 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MIOS (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d · 4e ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b
    SP1:                          -                                                     -                                               -                     
    SP2:                                                                                                                                                      
    SP3:                          -     -                                                                                                                     
    SP4:                                                                                                                                                      
    SP5:                          -     -     -                                                                                                               


    ECgene alternative splicing isoforms for MIOS

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MIOS expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGTTCTGTTC
    MIOS Expression
    About this image

    MIOS Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MIOS Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.520215
        Custom PCR Arrays for MIOS
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for MIOS
    OriGene qSTAR qPCR primer pairs in human, mouse for MIOS
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MIOS
    QuantiTect SYBR Green Assays in human, mouse, rat MIOS
    QuantiFast Probe-based Assays in human, mouse, rat MIOS
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MIOS

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for MIOS gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mios1 , 5 missing oocyte, meiosis regulator, homolog (Drosophila)1, 5 91.96(n)1
    98.17(a)1
      6 (3.51 cM)5
    2528751  NM_145374.21  NP_663349.21 
     82092225 
    chicken
    (Gallus gallus)
    Aves MIOS1 missing oocyte, meiosis regulator, homolog (Drosophila) 81.69(n)
    92.11(a)
      420577  XM_418678.4  XP_418678.2 
    lizard
    (Anolis carolinensis)
    Reptilia MIOS6
    missing oocyte, meiosis regulator, homolog (Drosop...
    90(a)
    1 ↔ 1
    6(23668172-23680423)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.114782 Xenopus laevis transcribed sequence with weak similarity more 80.34(n)    BX843109.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc559582 hypothetical protein MGC55958 74.81(n)   393208  BC047198.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta mio1 missing oocyte 46.06(n)
    36.92(a)
      33399  NM_134812.3  NP_608656.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SEA4(YBL104C)4 Subunit of the SEA (Seh1-associated) complex, a coatomer-related more   --   2(21293-18177) 852170  NP_009446.2 


    ENSEMBL Gene Tree for MIOS (if available)
    TreeFam Gene Tree for MIOS (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MIOS (see all 1087)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs105279741,2
    C--7474387(+) TGCAC-/GT/GTGTG
    TGTGTGTGTGT
    GTGTG
    1 -- int11NA 2
    rs1153004901,2
    C,F--7604646(+) GTCACC/TTAAAA 1 -- us2k11Minor allele frequency- T:0.05WA 118
    rs9726001,2
    C,H--7604656(+) AGAAGA/GTAAGA 1 -- us2k113Minor allele frequency- G:0.03MN NA WA CSA EA 558
    rs1932667971,2
    --7604773(+) CATCTC/TCTGAG 1 -- us2k10--------
    rs1150189741,2
    F--7604844(+) ATTGAT/ACTGAG 1 -- us2k11Minor allele frequency- A:0.02WA 118
    rs786301271,2
    F--7604858(+) TTGTGT/GGGGGG 1 -- us2k11Minor allele frequency- G:0.09WA 118
    rs38238421,2
    C,F,A,H--7604913(-) TCACTC/TCAAAC 1 -- us2k127Minor allele frequency- T:0.49NS EA NA WA 2586
    rs1165473661,2
    F--7604969(+) CCTACA/GTTCTT 1 -- us2k11Minor allele frequency- G:0.02WA 118
    rs1429403151,2
    --7605083(+) GCCATC/TACCAC 1 -- us2k10--------
    rs37575331,2
    C,F,H--7605203(-) CAAAAC/GTGAGT 1 -- us2k111Minor allele frequency- G:0.17NA NS EA WA 918

    HapMap Linkage Disequilibrium report for MIOS (7606503 - 7648560 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for MIOS:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv7158n71CNV Gain21882294
    nsv8043CNV Gain18304495
    nsv887477CNV Gain21882294
    dgv7159n71CNV Gain21882294
    esv2752174CNV Gain17911159

    Human Gene Mutation Database (HGMD): MIOS
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MIOS
    DNA2.0 Custom Variant and Variant Library Synthesis for MIOS

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 615359    OMIM disorders: --

    2 diseases for MIOS:    
    About MalaCards
    gastroparesis    malaria


    MIOS for disorders           About GeneDecksing


    Export disorders for MIOS gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MIOS gene, integrated from 10 sources (see all 21):
    (articles sorted by number of sources associating them with MIOS)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    2. missing oocyte encodes a highly conserved nuclear protein required for the maintenance of the meiotic cycle and oocyte identity in Drosophila. (PubMed id 14973288)1, 3 Iida T. and Lilly M.A. (Development 2004)
    3. A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1. (PubMed id 23723238)2 Bar-Peled L....Sabatini D.M. (Science 2013)
    4. The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition. (PubMed id 24163370)1 Lu L....Zhang L. (J. Biol. Chem. 2013)
    5. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    6. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    7. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    8. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    9. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    10. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (Sci. Signal. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 54468 HGNC: 21905 AceView: FLJ20323 Ensembl:ENSG00000164654 euGenes: HUgn54468
    ECgene: MIOS H-InvDB: MIOS

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MIOS Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MIOS gene:
    Search GeneIP for patents involving MIOS

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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