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Aliases for MIOS Gene

Aliases for MIOS Gene

  • Missing Oocyte, Meiosis Regulator, Homolog (Drosophila) 2 3 5
  • WD Repeat-Containing Protein Mio 2
  • WUGSC:H_DJ1159O04.1 3
  • H_DJ1159O04.1 3
  • MIO 3

External Ids for MIOS Gene

Previous GeneCards Identifiers for MIOS Gene

  • GC07P007455

Summaries for MIOS Gene

GeneCards Summary for MIOS Gene

MIOS (Missing Oocyte, Meiosis Regulator, Homolog (Drosophila)) is a Protein Coding gene. Among its related pathways are PI3K / Akt Signaling.

UniProtKB/Swiss-Prot for MIOS Gene

  • As a component of the GATOR2 complex, inhibits GATOR1 complex, an inhibitor of the amino acid-sensing branch of the TORC1 pathway.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIOS Gene

Genomics for MIOS Gene

Regulatory Elements for MIOS Gene

Enhancers for MIOS Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MIOS on UCSC Golden Path with GeneCards custom track

Promoters for MIOS Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MIOS on UCSC Golden Path with GeneCards custom track

Genomic Location for MIOS Gene

Chromosome:
7
Start:
7,566,872 bp from pter
End:
7,608,929 bp from pter
Size:
42,058 bases
Orientation:
Plus strand

Genomic View for MIOS Gene

Genes around MIOS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIOS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIOS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIOS Gene

Proteins for MIOS Gene

  • Protein details for MIOS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NXC5-MIO_HUMAN
    Recommended name:
    WD repeat-containing protein mio
    Protein Accession:
    Q9NXC5
    Secondary Accessions:
    • B2RTV6
    • O75216
    • Q7L551
    • Q9H092

    Protein attributes for MIOS Gene

    Size:
    875 amino acids
    Molecular mass:
    98584 Da
    Quaternary structure:
    • Within the GATOR complex, component of the GATOR2 subcomplex, made of MIOS, SEC13, SEH1L, WDR24 and WDR59. The GATOR complex strongly interacts with RRAGA/RRAGC and RRAGB/RRAGC heterodimers.

    Alternative splice isoforms for MIOS Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MIOS Gene

Proteomics data for MIOS Gene at MOPED

Post-translational modifications for MIOS Gene

  • Ubiquitination at Lys 479
  • Modification sites at PhosphoSitePlus

Other Protein References for MIOS Gene

No data available for DME Specific Peptides for MIOS Gene

Domains & Families for MIOS Gene

Suggested Antigen Peptide Sequences for MIOS Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NXC5

UniProtKB/Swiss-Prot:

MIO_HUMAN :
  • Belongs to the WD repeat mio family.
  • Contains 6 WD repeats.
Family:
  • Belongs to the WD repeat mio family.
Similarity:
  • Contains 6 WD repeats.
genes like me logo Genes that share domains with MIOS: view

No data available for Gene Families for MIOS Gene

Function for MIOS Gene

Molecular function for MIOS Gene

UniProtKB/Swiss-Prot Function:
As a component of the GATOR2 complex, inhibits GATOR1 complex, an inhibitor of the amino acid-sensing branch of the TORC1 pathway.
genes like me logo Genes that share phenotypes with MIOS: view

Animal Model Products

CRISPR Products

miRNA for MIOS Gene

miRTarBase miRNAs that target MIOS

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MIOS Gene

Localization for MIOS Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MIOS Gene COMPARTMENTS Subcellular localization image for MIOS gene
Compartment Confidence
lysosome 5
nucleus 5
vacuole 5
cytosol 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for MIOS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005765 lysosomal membrane IDA 17897319
genes like me logo Genes that share ontologies with MIOS: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MIOS Gene

Pathways & Interactions for MIOS Gene

SuperPathways for MIOS Gene

Superpath Contained pathways
1 PI3K / Akt Signaling
genes like me logo Genes that share pathways with MIOS: view

Pathways by source for MIOS Gene

1 Cell Signaling Technology pathway for MIOS Gene

Gene Ontology (GO) - Biological Process for MIOS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0034198 cellular response to amino acid starvation IMP 23723238
genes like me logo Genes that share ontologies with MIOS: view

No data available for SIGNOR curated interactions for MIOS Gene

Drugs & Compounds for MIOS Gene

No Compound Related Data Available

Transcripts for MIOS Gene

Unigene Clusters for MIOS Gene

Missing oocyte, meiosis regulator, homolog (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MIOS Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d · 4e ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b
SP1: - - -
SP2:
SP3: - -
SP4:
SP5: - - -
SP6: - -
SP7:

Relevant External Links for MIOS Gene

GeneLoc Exon Structure for
MIOS
ECgene alternative splicing isoforms for
MIOS

Expression for MIOS Gene

mRNA expression in normal human tissues for MIOS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MIOS Gene

This gene is overexpressed in Muscle - Skeletal (x7.9).

Protein differential expression in normal tissues from HIPED for MIOS Gene

This gene is overexpressed in Lymph node (11.6), Peripheral blood mononuclear cells (10.3), and Blymphocyte (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MIOS Gene



SOURCE GeneReport for Unigene cluster for MIOS Gene Hs.520215

genes like me logo Genes that share expression patterns with MIOS: view

Protein tissue co-expression partners for MIOS Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for MIOS Gene

Orthologs for MIOS Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MIOS Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MIOS 35
  • 92.99 (n)
  • 98.06 (a)
MIOS 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MIOS 35
  • 94.1 (n)
  • 99.2 (a)
MIOS 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mios 35
  • 91.96 (n)
  • 98.17 (a)
Mios 16
Mios 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MIOS 35
  • 99.43 (n)
  • 100 (a)
MIOS 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mios 35
  • 92.46 (n)
  • 98.06 (a)
oppossum
(Monodelphis domestica)
Mammalia MIOS 36
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MIOS 36
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves MIOS 35
  • 81.69 (n)
  • 92.11 (a)
MIOS 36
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MIOS 36
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mios 35
  • 76.47 (n)
  • 88.56 (a)
Str.1409 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.11478 35
zebrafish
(Danio rerio)
Actinopterygii mios 35
  • 70.08 (n)
  • 82.76 (a)
zgc55958 35
mios 36
  • 82 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12236 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007984 35
  • 44.72 (n)
  • 37 (a)
fruit fly
(Drosophila melanogaster)
Insecta mio 35
  • 46.06 (n)
  • 36.92 (a)
mio 36
  • 33 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SEA4 36
  • 23 (a)
OneToOne
SEA4 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 45 (a)
OneToMany
CSA.3384 36
  • 45 (a)
OneToMany
Species with no ortholog for MIOS:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIOS Gene

ENSEMBL:
Gene Tree for MIOS (if available)
TreeFam:
Gene Tree for MIOS (if available)

Paralogs for MIOS Gene

No data available for Paralogs for MIOS Gene

Variants for MIOS Gene

Sequence variations from dbSNP and Humsavar for MIOS Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1013002 -- 7,584,954(+) TTCTT(A/G)TAGTT intron-variant
rs6949441 -- 7,597,693(+) TTTTT(G/T)TTTGT intron-variant
rs6956562 -- 7,593,622(+) GGCAC(A/G)GTGAC intron-variant
rs6958110 -- 7,594,706(+) GTTCT(A/G)TTTTC intron-variant
rs1544465 -- 7,579,089(+) TGTAT(A/G)GGACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MIOS Gene

Variant ID Type Subtype PubMed ID
esv2752174 CNV Gain 17911159
dgv7158n71 CNV Gain 21882294
dgv7159n71 CNV Gain 21882294
nsv887477 CNV Gain 21882294
nsv8043 CNV Gain 18304495

Variation tolerance for MIOS Gene

Residual Variation Intolerance Score: 4.26% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.74; 32.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MIOS Gene

Human Gene Mutation Database (HGMD)
MIOS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MIOS Gene

Disorders for MIOS Gene

Relevant External Links for MIOS

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIOS

No disorders were found for MIOS Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIOS Gene

Publications for MIOS Gene

  1. A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1. (PMID: 23723238) Bar-Peled L. … Sabatini D.M. (Science 2013) 3 4 67
  2. missing oocyte encodes a highly conserved nuclear protein required for the maintenance of the meiotic cycle and oocyte identity in Drosophila. (PMID: 14973288) Iida T. … Lilly M.A. (Development 2004) 2 3
  3. Proteomic analysis and identification of cellular interactors of the giant ubiquitin ligase HERC2. (PMID: 25476789) Galligan J.T. … Howley P.M. (J. Proteome Res. 2015) 3
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for MIOS Gene

Sources for MIOS Gene

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