MIOS Gene
protein-coding GIFtS: 44
GCID: GC07P007574
|
|
missing oocyte, meiosis regulator, homolog (Drosophila)
| |
Aliases
for MIOS gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Missing Oocyte, Meiosis Regulator, Homolog (Drosophila)1 2 | | FLJ203231 | | H_DJ1159O04.12 | | WUGSC:H_DJ1159O04.12 | | WD Repeat-Containing Protein Mio2 |
Export aliases for MIOS gene to outside databasesPrevious GC identifer: GC07P007455 |
Summaries
for MIOS gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for MIOS gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007819.17 NT_079592.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MIOS gene promoter:
SREBP-1c Tal-1beta AP-2gamma SREBP-1b FOXL1 E47 SREBP-1a AP-2beta AP-2alpha AP-2alphaA
Other transcription factors
Search SABiosciences Chromatin IP Primers for MIOS
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MIOS |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7p21.3 Ensembl cytogenetic band: 7p21.3 HGNC cytogenetic band: 7p21.3MIOS Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07P007574: view genomic region
(about GC identifiers)
Start:
|
7,606,503 bp from pter |
End:
|
7,648,560 bp from pter |
Size:
|
42,058 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr7+,CRA_TCAG 7,653,840-7,694,325 |
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Proteins
for MIOS gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MIO_HUMAN, Q9NXC5 (See
protein sequence)Recommended Name: WD repeat-containing protein mio Size: 875 amino acids; 98584 Da
Secondary accessions: B2RTV6 O75216 Q7L551 Q9H092Alternative splicing: 2 isoforms: Q9NXC5-1 Q9NXC5-2 Explore the universe of human proteins at neXtProt for MIOS: NX_Q9NXC5
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NXC5
MIOS Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_061878.3
ENSEMBL proteins: ENSP00000339881 ENSP00000384088 ENSP00000413050 ENSP00000410752 ENSP00000407518 ENSP00000413489
Human Recombinant Protein Products:
MIOS Antibody Products:
Assay Products for MIOS: |
Protein
Domains /
Families
for MIOS gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MIOS for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9NXC5ProtoNet protein and cluster: Q9NXC5 1 Blocks protein family: IPB001680 G-protein beta WD-40 repeat signature
UniProtKB/Swiss-Prot: MIO_HUMAN, Q9NXC5Similarity: Belongs to the WD repeat mio familySimilarity: Contains 6 WD repeats |
Function
for MIOS gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MIOS (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MIOS (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: MIOS (NM_019005) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MIOS | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MIOS |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MIOS |
|
Pathways & Interactions
for MIOS gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MIOS
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
5/78 Interacting proteins for MIOS (Q9NXC53 ENSP000003398814) via UniProtKB, MINT, STRING, and/or I2D (see all 78)About this table
|
Drugs & Compounds
for MIOS gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MIOS
Search CenterWatch for drugs/clinical trials and news about MIOS / MIO
|
Transcripts
for MIOS gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MIOS gene: NM_019005.3 Unigene Cluster for MIOS: Missing oocyte, meiosis regulator, homolog (Drosophila) Hs.520215 [show with all ESTs]Unigene Representative Sequence: AL1368929 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000340080(uc003srf.3 uc010ktp.1) ENST00000405785 ENST00000433635
ENST00000456533 ENST00000433056 ENST00000445169 ENST00000461907 ENST00000493227(uc003srg.3 uc010ktq.3)
ENST00000479694
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MIOS (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MIOS (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: MIOS (NM_019005) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MIOS | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MIOS |
Additional cDNA sequence: AK294561.1 AL136892.1 BC005883.2 BC068512.1 BC140833.1 BC140834.1 13 DOTS entries: DT.415945 DT.95161181 DT.121128113 DT.100783156 DT.97810691 DT.40117393 DT.75101384 DT.100023466 DT.121128107 DT.121128111 DT.40311337 DT.100844431 DT.121128146 24/166 AceView cDNA sequences (see all 166): BG685105 BM023372 BM127090 AA767044 CD243481 BQ431850 AI914166 BM684587 BM727267 BU182526 AA847203 AA865016 AA806714 BQ878955 AA831394 CA772428 AI123551 AA033696 AA375271 W76427 W88763 AA906626 BQ421959 AA759303
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for MIOS (see all 7) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | · | 4d | · | 4e | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13a | · | 13b |
|---|
|
| SP1: | | | | | | | | | - | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | - | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for MIOS
|
Expression
for MIOS gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MIOS expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGTTCTGTTC
About this image
See MIOS Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MIOS
SOURCE GeneReport for Unigene cluster: Hs.520215
SABiosciences Custom PCR Arrays for MIOS
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MIOS
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MIOS | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MIOS | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MIOS | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MIOS |
Orthologs
for MIOS gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for MIOS gene from 6/25 species (see all 25) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Mios1 , 5 |
missing oocyte, meiosis regulator, homolog (Drosophila)1, 5 |
91.96(n)1
98.17(a)1 |
|
6 (3.51 cM)5
2528751 NM_145374.21 NP_663349.21
82092225 |
chicken
(Gallus gallus) |
Aves |
MIOS1 |
missing oocyte, meiosis regulator, homolog (Drosophila) |
81.69(n)
92.11(a) |
|
420577 XM_418678.3 XP_418678.2 |
lizard
(Anolis carolinensis) |
Reptilia |
MIOS6 |
-- |
90(a) |
1 ↔ 1 |
6(23668172-23680363) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.114782 |
Xenopus laevis transcribed sequence with weak similarity more |
80.34(n) |
|
BX843109.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
zgc559582 |
hypothetical protein MGC55958 |
74.81(n) |
|
393208 BC047198.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
mio1 |
missing oocyte |
45.54(n)
36.36(a) |
|
33399 NM_134812.2 NP_608656.1 |
ENSEMBL Gene Tree for MIOS (if available)
TreeFam Gene Tree for MIOS (if available) |
Paralogs
for MIOS gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for MIOS gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MIOS (7606503 - 7648560 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for MIOS
1 CNV: 8546 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MIOS |
|
Disorders
/ Diseases
for MIOS gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MIOS for disorders About GeneDecksing
1  disease for MIOS: About MalaCardsgastroparesis
Export disorders for MIOS gene to outside databases
|
Publications
for MIOS gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MIOS gene, integrated from 9 sources (see all 16):
(articles sorted by number of sources associating them with MIOS) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- missing oocyte encodes a highly conserved nuclear protein required for the maintenance of the meiotic cycle and oocyte identity in Drosophila. (PubMed id 14973288)1, 3 Iida T. and Lilly M.A. (2004)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
- Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (2009)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
|
External Searches for MIOS gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MIOS gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MIOS gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MIOS gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MIOS | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for MIOS gene:
Search GeneIP for patents involving MIOS
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MIOS gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for MIOS | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MIOS | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MIOS | | | OriGene Protein Over-expression Lysate for MIOS | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MIOS | | OriGene 3'-UTR Clone for MIOS | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MIOS | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MIOS | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for MIOS | | OriGene Custom Protein Services for MIOS | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MIOS | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MIOS | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MIOS | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MIOS | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MIOS | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MIOS |
| |
 |  |  |  | |
| | | | Search Tocris compounds for MIOS |
| |  |  |  |  | | | | |
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 | | | MIOS Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MIOS |
|  |  |  | | | | Search ThermoFisher Antibodies for MIOS |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MIOS |
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