Aliases for MINPP1 Gene
External Ids for MINPP1 Gene
Previous GeneCards Identifiers for MINPP1 Gene
This gene encodes multiple inositol polyphosphate phosphatase; an enzyme that removes 3-phosphate from inositol phosphate substrates. It is the only enzyme known to hydrolzye inositol pentakisphosphate and inositol hexakisphosphate. This enzyme also converts 2,3 bisphosphoglycerate (2,3-BPG) to 2-phosphoglycerate; an activity formerly thought to be exclusive to 2,3-BPG synthase/2-phosphatase (BPGM) in the Rapoport-Luebering shunt of the glycolytic pathway.[provided by RefSeq, Sep 2009]
GeneCards Summary for MINPP1 Gene
MINPP1 (Multiple Inositol-Polyphosphate Phosphatase 1) is a Protein Coding gene. Diseases associated with MINPP1 include Thyroid Cancer, Nonmedullary, 2 and Polyposis, Juvenile Intestinal. Among its related pathways are Inositol phosphate metabolism (KEGG) and Synthesis of IPs in the ER lumen. GO annotations related to this gene include phosphatase activity and phosphohistidine phosphatase activity.
UniProtKB/Swiss-Prot for MINPP1 Gene
Acts as a phosphoinositide 5- and phosphoinositide 6-phosphatase and regulates cellular levels of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6). Also acts as a 2,3-bisphosphoglycerate 3-phosphatase, by mediating the dephosphorylation of 2,3-bisphosphoglycerate (2,3-BPG) to produce phospho-D-glycerate without formation of 3-phosphoglycerate. May play a role in bone development (endochondral ossification). May play a role in the transition of chondrocytes from proliferation to hypertrophy (By similarity).