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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MINPP1 Gene

protein-coding   GIFtS: 64
GCID: GC10P089264

multiple inositol-polyphosphate phosphatase 1

(Previous names: multiple inositol polyphosphate histidine phosphatase,...)
 Explore 12 diseases affiliated with
MINPP1 via our new
 Human Malady Compendium 
Biological research products
for MINPP1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Multiple Inositol-Polyphosphate Phosphatase 11 2     EC 3.1.3.623 8
MIPP1 2 3     HIPER12 5
Multiple Inositol Polyphosphate Histidine Phosphatase, 11 2     MINPP22
Inositol (1,3,4,5)-Tetrakisphosphate 3-Phosphatase2 3     Multiple Inositol Polyphosphate Phosphatase 12
Ins(1,3,4,5)P(4) 3-Phosphatase2 3     Multiple Inositol Polyphosphate Phosphatase 22
2,3-Bisphosphoglycerate 3-Phosphatase2 3     EC 3.1.3.803
2,3-BPG Phosphatase2 3     

External Ids:    HGNC: 71021   Entrez Gene: 95622   Ensembl: ENSG000001077897   OMIM: 6053915   UniProtKB: Q9UNW13   

Export aliases for MINPP1 gene to outside databases

Previous GC identifers: GC10P088146 GC10P088486 GC10P089395 GC10P088929 GC10P089254 GC10P082898


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MINPP1:
This gene encodes multiple inositol polyphosphate phosphatase; an enzyme that removes 3-phosphate from inositol
phosphate substrates. It is the only enzyme known to hydrolzye inositol pentakisphosphate and inositol
hexakisphosphate. This enzyme also converts 2,3 bisphosphoglycerate (2,3-BPG) to 2-phosphoglycerate; an activity
formerly thought to be exclusive to 2,3-BPG synthase/2-phosphatase (BPGM) in the Rapoport-Luebering shunt of the
glycolytic pathway.(provided by RefSeq, Sep 2009)

UniProtKB/Swiss-Prot: MINP1_HUMAN, Q9UNW1
Function: Acts as a phosphoinositide 5- and phosphoinositide 6-phosphatase and regulates cellular levels of inositol
pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6). Also acts as a 2,3-bisphosphoglycerate 3-phosphatase,
by mediating the dephosphorylation of 2,3-bisphosphoglycerate (2,3-BPG) to produce phospho-D-glycerate without
formation of 3-phosphoglycerate. May play a role in bone development (endochondral ossification)

Gene Wiki entry for MINPP1


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.1  NT_030059.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MINPP1 gene promoter:
         AML1a   Tal-1   Lmo2   Nkx2-5   E47   FOXL1   HEN1   POU2F1   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMINPP1 promoter sequence
   Search SABiosciences Chromatin IP Primers for MINPP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MINPP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q23   Ensembl cytogenetic band:  10q23.2   HGNC cytogenetic band: 10q23

MINPP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MINPP1 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P089264:  view genomic region     (about GC identifiers)

Start:
89,264,223 bp from pter      End:
89,313,218 bp from pter
Size:
48,996 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MINP1_HUMAN, Q9UNW1 (See protein sequence)
Recommended Name: Multiple inositol polyphosphate phosphatase 1 precursor  
Size: 487 amino acids; 55051 Da
Subcellular location: Endoplasmic reticulum lumen (By similarity)
Sequence caution: Sequence=BAD93056.1; Type=Erroneous initiation;
Secondary accessions: F5H683 O95172 O95286 Q59EJ2 Q9UGA3
Alternative splicing: 4 isoforms:  Q9UNW1-1   Q9UNW1-2   Q9UNW1-3   Q9UNW1-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MINPP1: NX_Q9UNW1

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9UNW1

  • 3 DME Specific Peptides for MINPP1 (Q9UNW1)
     NDKLMRFFDHCEKFLT  TALYHVEAFKTGPEMQ  CTPVQLVALIRHGTRYPT 

    MINPP1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001171588.1  NP_001171589.1  NP_004888.2  

    ENSEMBL proteins: 
     ENSP00000361064   ENSP00000361062   ENSP00000437823  
    Reactome Protein details: Q9UNW1
    Human Recombinant Protein Products: 
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    Novus Biologicals MINPP1 Protein
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    Uscn Proteins for MINPP1

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum TAS10087200
    GO:0005788endoplasmic reticulum lumen IEA--


    MINPP1 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for MINPP1


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    MINPP1 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR000560 His_Pase_superF_clade-2
     IPR016274 Histidine_acid_Pase_euk

    Graphical View of Domain Structure for InterPro Entry Q9UNW1

    ProtoNet protein and cluster: Q9UNW1

    1 Blocks protein family: IPB000560 Histidine acid phosphatase

    UniProtKB/Swiss-Prot: MINP1_HUMAN, Q9UNW1
    Similarity: Belongs to the histidine acid phosphatase family. MINPP1 subfamily


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: MINP1_HUMAN, Q9UNW1
    Function: Acts as a phosphoinositide 5- and phosphoinositide 6-phosphatase and regulates cellular levels of inositol
    pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6). Also acts as a 2,3-bisphosphoglycerate 3-phosphatase,
    by mediating the dephosphorylation of 2,3-bisphosphoglycerate (2,3-BPG) to produce phospho-D-glycerate without
    formation of 3-phosphoglycerate. May play a role in bone development (endochondral ossification)
    Catalytic activity: Myo-inositol hexakisphosphate + H(2)O = myo-inositol pentakisphosphate (mixed isomers) + phosphate
    Catalytic activity: 2,3-bisphospho-D-glycerate + H(2)O = 2-phospho-D-glycerate + phosphate
    Biophysicochemical properties: Kinetic parameters: KM=0.61 mM for 2,3-bisphosphoglycerate; Vmax=15.8 nmol/min/mg enzyme
    with 2,3-bisphospho-D-glycerate as substrate;

         Genatlas biochemistry entry for MINPP1:
    multiple inositol polyphosphate phosphatase 1,belonging to a distinct group of histidine phosphatase

    Enzyme Numbers (IUBMB): EC 3.1.3.621 2 EC 3.1.3.801

    miRNA
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    hsa-miR-30c hsa-miR-3607-3p hsa-miR-30a hsa-miR-30b hsa-miR-30d hsa-miR-30e
    SwitchGear 3'UTR luciferase reporter plasmidMINPP1 3' UTR sequence
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MINPP1

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    Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003993acid phosphatase activity IEA--
    GO:0008969phosphohistidine phosphatase activity TAS10087200
    GO:0030351inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity ----
    GO:0030352inositol-1,4,5,6-tetrakisphosphate 6-phosphatase activity ----
    GO:0034417bisphosphoglycerate 3-phosphatase activity IDA18413611


    MINPP1 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for MINPP1:
     Decreased Salmonella enterica   Decreased focal adhesion (FA)  

    Animal Models:
         Mouse knock-out Minpp1tm1Prr for MINPP1
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Minpp1):
     normal 

    MINPP1 for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/6 super-pathways (see all 6About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1D-myo-inositol (1,3,4)-trisphosphate biosynthesis
    D-myo-inositol (1,3,4)-trisphosphate biosynthesis1.00
    superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism0.75
    2Inositol phosphate metabolism
    Inositol phosphate metabolism1.00
    superpathway of inositol phosphate compounds0.59
    3D-myo-inositol (3,4,5,6)-tetrakisphosphate biosynthesis
    D-myo-inositol (1,4,5,6)-tetrakisphosphate biosynthesis0.67
    Synthesis of IPs in the ER lumen0.00
    4Rapoport-Luebering glycolytic shunt
    Rapoport-Luebering glycolytic shunt1.00
    5Metabolism
    Metabolism1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5 BioSystems Pathways for MINPP1 
        Rapoport-Luebering glycolytic shunt
    D-myo-inositol (1,3,4)-trisphosphate biosynthesis
    D-myo-inositol (1,4,5,6)-tetrakisphosphate biosynthesis
    superpathway of inositol phosphate compounds
    superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism

    3        Reactome Pathways for MINPP1
        Synthesis of IPs in the ER lumen
    Metabolism
    Inositol phosphate metabolism


    1         Kegg Pathway  (Kegg details for MINPP1):
        Inositol phosphate metabolism


    MINPP1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MINPP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/30 Interacting proteins for MINPP1 (Q9UNW13 ENSP000003610644) via UniProtKB, MINT, STRING, and/or I2D (see all 30)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ACTA1P681333, ENSP000003556454I2D: score=2 STRING: ENSP00000355645
    SRFP118313, ENSP000002653544I2D: score=1 STRING: ENSP00000265354
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    BPGMENSP000003420324STRING: ENSP00000342032
    ITPKCENSP000002633704STRING: ENSP00000263370
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001503ossification NAS9923613
    GO:0006797polyphosphate metabolic process TAS10087200
    GO:0030282bone mineralization NAS9923613


    MINPP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MINPP1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for MINPP1

    5 HMDB Compounds for MINPP1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Inositol 1,3,4,5-tetraphosphate1,3,4,5-tetrakis(dihydrogen phosphate) myo-Inositol (see all 16)102850-29-3--
    Inositol 1,4,5-trisphosphate1D-myo-Inositol 1,4,5-trisphosphate (see all 4)88269-39-0--
    Myo-inositol hexakisphosphate1D-myo-Inositol 1,2,3,4,5,6-hexakisphosphate (see all 9)83-86-3--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--
    2 Novoseek chemical compound relationships for MINPP1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    phytate 67.7 2 15979280 (2)
    inositol 54.8 1 9923613 (1)

    Search CenterWatch for drugs/clinical trials and news about MINPP1 / MINP1 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MINPP1 gene (3 alternative transcripts): 
    NM_001178117.1  NM_001178118.1  NM_004897.4  

    Unigene Cluster for MINPP1:

    Multiple inositol-polyphosphate phosphatase 1
    Hs.121260  [show with all ESTs]
    Unigene Representative Sequence: NM_004897
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000371996(uc001keu.3 uc009xtf.2) ENST00000371994(uc001kev.3)
    ENST00000472891 ENST00000536010(uc021pvv.1)

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    hsa-miR-30c hsa-miR-3607-3p hsa-miR-30a hsa-miR-30b hsa-miR-30d hsa-miR-30e
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    Additional cDNA sequence: 

    AB209819.1 AF046914.1 AF084943.1 AF084944.1 AK304624.1 AK309176.1 AK312937.1 AL050356.1 
    AY358938.1 BC032504.1 

    6 DOTS entries:

    DT.410746  DT.100817951  DT.100817947  DT.100817952  DT.100817954  DT.121249170 

    24/117 AceView cDNA sequences (see all 117):

    AW961214 AF084944 CR595009 BU625626 BX351615 BX396922 BQ002769 AA666012 
    Z44288 AA315402 BQ004246 BC032504 F10100 BQ575074 BF968487 BQ632253 
    BQ003601 AU279759 AW204904 F12482 NM_004897 CA442671 BE048544 Z40249 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for MINPP1    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c
    SP1:                                      -                     
    SP2:                                                            
    SP3:                    -                 -                     
    SP4:                                                            


    ECgene alternative splicing isoforms for MINPP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MINPP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AAATGTAAGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See MINPP1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MINPP1

    SOURCE GeneReport for Unigene cluster: Hs.121260

    UniProtKB/Swiss-Prot: MINP1_HUMAN, Q9UNW1
    Tissue specificity: Widely expressed with highest levels in kidney, liver and placenta

        SABiosciences Custom PCR Arrays for MINPP1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MINPP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MINPP1 gene from 7/25 species (see all 25)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Minpp11 , 5 multiple inositol polyphosphate histidine phosphatase more1, 5 81.7(n)1
    83.16(a)1
      19 (27.25 cM)5
    173301  NM_010799.21  NP_034929.11 
     324857695 
    chicken
    (Gallus gallus)
    Aves MINPP11 multiple inositol-polyphosphate phosphatase 1 66.12(n)
    60.84(a)
      395356  NM_204644.1  NP_989975.1 
    lizard
    (Anolis carolinensis)
    Reptilia MINPP16
    --
    54(a)
    1 ↔ 1
    GL343246.1(1154804-1173426)
    zebrafish
    (Danio rerio)
    Actinopterygii zgc560802 similar to multiple inositol polyphosphate histidine more 74.82(n)   394075  BC047824.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Mipp21 , 3 inositol/phosphatidylinositol phosphatase3
    Multiple inositol polyphosphate phosphatase 21
    26(a)3
    42.25(n)1
    30.27(a)1
      5D43
    315441  NM_078500.31  NP_511055.11 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G098701 histidine acid phosphatase-like protein 42.09(n)
    28.91(a)
      837519  NM_100861.3  NP_563856.1 
    rice
    (Oryza sativa)
    Liliopsida Os03g08181001 hypothetical protein 43.4(n)
    28.96(a)
      4334577  NM_001058240.1  NP_001051705.1 


    ENSEMBL Gene Tree for MINPP1 (if available)
    TreeFam Gene Tree for MINPP1 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/806 NCBI SNPs in MINPP1 are shown (see all 806    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs797152951,2
    F,--82897257(+) ATAGCG/AGCCTA 2 -- us2k11Minor allele frequency- A:0.06WA 118
    rs2001422361,2
    C--82897336(+) TTTCAA/GANNNN 2 -- us2k10--------
    rs733442551,2
    C,F,--82897907(+) CTAAAT/AGCTAA 2 -- us2k15Minor allele frequency- A:0.15WA CSA NA 244
    rs1163351851,2
    C,F,--82898010(+) CTAAAG/AATGGT 2 -- us2k11Minor allele frequency- A:0.03WA 118
    rs741504701,2
    C,--82898522(+) CATGAC/TTCAAT 2 -- us2k12Minor allele frequency- T:0.05WA 120
    rs22331631,2
    C,--82898994(+) CACACC/TCAAAA 2 -- ut512Minor allele frequency- T:0.04NA 122
    rs741504711,2
    C,--82899103(+) GCCACG/CGCTGT 2 -- ut512Minor allele frequency- C:0.03WA 120
    rs22331641,2
    --82899149(+) GAGCCA/TCAAGT 2 -- ut510--------
    rs22331651,2
    C,--82899204(+) GCCAGA/GGGTTG 2 -- ut512Minor allele frequency- G:0.13WA 120
    rs22331661,2
    --82899266(+) GCCCTC/GCAGAC 2 -- ut510--------

    HapMap Linkage Disequilibrium report for MINPP1 (89264223 - 89313218 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 13 variations for MINPP1
         7 CNVs: 58478 58477 65747 2885 65750 65749 3815
         6 Indels: 85421 39773 75350 75349 85422 75348
    Human Gene Mutation Database (HGMD): MINPP1

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MINPP1
    DNA2.0 Custom Variant and Variant Library Synthesis for MINPP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    MINPP1 for disorders           About GeneDecksing

    OMIM gene information: 605391   
    OMIM disorders: 188470  
    UniProtKB/Swiss-Prot: MINP1_HUMAN, Q9UNW1
  • Note=Defects in MINPP1 may be involved in follicular thyroid tumors development

  • 12 diseases for MINPP1:    About MalaCards
    bannayan-riley-ruvalcaba syndrome    ruvalcaba syndrome    cowden disease    follicular thyroid carcinoma
    fanconi's anemia    thyroid carcinoma    thyroiditis    anemia
    alzheimer's disease    carcinoma    prostate cancer    prostatitis

    1 disease from the University of Copenhagen DISEASES database for MINPP1:
    Bannayan-Riley-Ruvalcaba syndrome

    1 Novoseek disease relationship for MINPP1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 5 11297621 (3)

    Human Genome Epidemiology (HuGE) Navigator: MINPP1 (3 documents)

    Export disorders for MINPP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MINPP1 gene, integrated from 9 sources (see all 26):
    (articles sorted by number of sources associating them with MINPP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Multiple inositol polyphosphate phosphatase: evolution as a distinct group within the histidine phosphatase family and chromosomal localization of the human and mouse genes to chromosomes 10q23 and 19. (PubMed id 10087200)1, 2, 3, 9 Chi H.... Reynolds P.R. (1999)
    2. Somatic mutation and germline variants of MINPP1, a phosphatase gene located in proximity to PTEN on 10q23.3, in follicular thyroid carcinomas. (PubMed id 11297621)1, 2, 9 Gimm O.... Eng C. (2001)
    3. The human and rat forms of multiple inositol polyphosphate phosphatase: functional homology with a histidine acid phosphatase up- regulated during endochondral ossification. (PubMed id 9923613)1, 2, 9 Caffrey J.J.... Shears S.B. (1999)
    4. Dephosphorylation of 2,3-bisphosphoglycerate by MIPP expands the regulatory capacity of the Rapoport-Luebering glycolytic shunt. (PubMed id 18413611)1, 2 Cho J....Shears S.B. (2008)
    5. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
    8. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    9. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
    10. Cloning and characterization of ectopically expressed transcripts for the actin-binding protein MIPP in mouse mammary carcinomas. (PubMed id 11536049)1, 9 VanHouten J.N....Asch B.B. (2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9562 HGNC: 7102 AceView: MINPP1 Ensembl:ENSG00000107789 euGenes: HUgn9562
    ECgene: MINPP1 Kegg: 9562 H-InvDB: MINPP1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MINPP1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MINPP1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MINPP1 gene:
    Search GeneIP for patents involving MINPP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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