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Aliases for MINPP1 Gene

Aliases for MINPP1 Gene

  • Multiple Inositol-Polyphosphate Phosphatase 1 2 3
  • Multiple Inositol Polyphosphate Histidine Phosphatase, 1 2 3
  • Inositol (1,3,4,5)-Tetrakisphosphate 3-Phosphatase 3 4
  • 2,3-Bisphosphoglycerate 3-Phosphatase 3 4
  • Ins(1,3,4,5)P(4) 3-Phosphatase 3 4
  • 2,3-BPG Phosphatase 3 4
  • EC 3.1.3.62 4 63
  • HIPER1 3 6
  • MIPP 3 4
  • Multiple Inositol Polyphosphate Phosphatase 1 3
  • Multiple Inositol Polyphosphate Phosphatase 2 3
  • EC 3.1.3.80 4
  • MINPP2 3

External Ids for MINPP1 Gene

Previous GeneCards Identifiers for MINPP1 Gene

  • GC10P088146
  • GC10P088486
  • GC10P089395
  • GC10P088929
  • GC10P089254
  • GC10P082898
  • GC10P089264

Summaries for MINPP1 Gene

Entrez Gene Summary for MINPP1 Gene

  • This gene encodes multiple inositol polyphosphate phosphatase; an enzyme that removes 3-phosphate from inositol phosphate substrates. It is the only enzyme known to hydrolzye inositol pentakisphosphate and inositol hexakisphosphate. This enzyme also converts 2,3 bisphosphoglycerate (2,3-BPG) to 2-phosphoglycerate; an activity formerly thought to be exclusive to 2,3-BPG synthase/2-phosphatase (BPGM) in the Rapoport-Luebering shunt of the glycolytic pathway.[provided by RefSeq, Sep 2009]

GeneCards Summary for MINPP1 Gene

MINPP1 (Multiple Inositol-Polyphosphate Phosphatase 1) is a Protein Coding gene. Diseases associated with MINPP1 include thyroid carcinoma, follicular and bannayan-riley-ruvalcaba syndrome. Among its related pathways are Metabolism and Inositol phosphate metabolism (KEGG). GO annotations related to this gene include acid phosphatase activity and bisphosphoglycerate 3-phosphatase activity.

UniProtKB/Swiss-Prot for MINPP1 Gene

  • Acts as a phosphoinositide 5- and phosphoinositide 6-phosphatase and regulates cellular levels of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6). Also acts as a 2,3-bisphosphoglycerate 3-phosphatase, by mediating the dephosphorylation of 2,3-bisphosphoglycerate (2,3-BPG) to produce phospho-D-glycerate without formation of 3-phosphoglycerate. May play a role in bone development (endochondral ossification).

Gene Wiki entry for MINPP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MINPP1 Gene

Genomics for MINPP1 Gene

Regulatory Elements for MINPP1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MINPP1 Gene

Start:
87,504,466 bp from pter
End:
87,553,461 bp from pter
Size:
48,996 bases
Orientation:
Plus strand

Genomic View for MINPP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MINPP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MINPP1 Gene

Proteins for MINPP1 Gene

  • Protein details for MINPP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UNW1-MINP1_HUMAN
    Recommended name:
    Multiple inositol polyphosphate phosphatase 1
    Protein Accession:
    Q9UNW1
    Secondary Accessions:
    • F5H683
    • O95172
    • O95286
    • Q59EJ2
    • Q9UGA3

    Protein attributes for MINPP1 Gene

    Size:
    487 amino acids
    Molecular mass:
    55051 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAD93056.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for MINPP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MINPP1 Gene

Proteomics data for MINPP1 Gene at MOPED

Selected DME Specific Peptides for MINPP1 Gene

Post-translational modifications for MINPP1 Gene

  • Glycosylation at Ser42, Asn242, and Asn481
  • Modification sites at PhosphoSitePlus

Other Protein References for MINPP1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

Domains for MINPP1 Gene

Protein Domains for MINPP1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UNW1

UniProtKB/Swiss-Prot:

MINP1_HUMAN :
  • Q9UNW1
Family:
  • Belongs to the histidine acid phosphatase family. MINPP1 subfamily.
genes like me logo Genes that share domains with MINPP1: view

No data available for Gene Families for MINPP1 Gene

Function for MINPP1 Gene

Molecular function for MINPP1 Gene

GENATLAS Biochemistry: multiple inositol polyphosphate phosphatase 1,belonging to a distinct group of histidine phosphatase
UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=0.61 mM for 2,3-bisphosphoglycerate {ECO:0000269 PubMed:18413611}; Vmax=15.8 nmol/min/mg enzyme with 2,3-bisphospho-D-glycerate as substrate {ECO:0000269 PubMed:18413611};
UniProtKB/Swiss-Prot CatalyticActivity: Myo-inositol hexakisphosphate + H(2)O = myo-inositol pentakisphosphate (mixed isomers) + phosphate.
UniProtKB/Swiss-Prot CatalyticActivity: 2,3-bisphospho-D-glycerate + H(2)O = 2-phospho-D-glycerate + phosphate.
UniProtKB/Swiss-Prot Function: Acts as a phosphoinositide 5- and phosphoinositide 6-phosphatase and regulates cellular levels of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6). Also acts as a 2,3-bisphosphoglycerate 3-phosphatase, by mediating the dephosphorylation of 2,3-bisphosphoglycerate (2,3-BPG) to produce phospho-D-glycerate without formation of 3-phosphoglycerate. May play a role in bone development (endochondral ossification).

Enzyme Numbers (IUBMB) for MINPP1 Gene

Gene Ontology (GO) - Molecular Function for MINPP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003993 acid phosphatase activity IEA --
GO:0008969 phosphohistidine phosphatase activity TAS 10087200
GO:0016791 phosphatase activity --
GO:0034417 bisphosphoglycerate 3-phosphatase activity IDA 18413611
GO:0052826 inositol hexakisphosphate 2-phosphatase activity IEA --
genes like me logo Genes that share ontologies with MINPP1: view

Phenotypes for MINPP1 Gene

MGI mutant phenotypes for MINPP1:
inferred from 1 alleles
GenomeRNAi human phenotypes for MINPP1:
genes like me logo Genes that share phenotypes with MINPP1: view

Animal Models for MINPP1 Gene

MGI Knock Outs for MINPP1:

Animal Model Products

CRISPR Products

miRNA for MINPP1 Gene

No data available for Transcription Factor Targeting and HOMER Transcription for MINPP1 Gene

Localization for MINPP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MINPP1 Gene

Endoplasmic reticulum lumen.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MINPP1 Gene COMPARTMENTS Subcellular localization image for MINPP1 gene
Compartment Confidence
endoplasmic reticulum 4
extracellular 2
mitochondrion 2
cytosol 1
lysosome 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for MINPP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum TAS 10087200
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with MINPP1: view

Pathways for MINPP1 Gene

genes like me logo Genes that share pathways with MINPP1: view

Gene Ontology (GO) - Biological Process for MINPP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001503 ossification NAS 9923613
GO:0006797 polyphosphate metabolic process TAS 10087200
GO:0016311 dephosphorylation TAS 10087200
GO:0030282 bone mineralization NAS 9923613
GO:0043647 inositol phosphate metabolic process TAS --
genes like me logo Genes that share ontologies with MINPP1: view

Compounds for MINPP1 Gene

(5) HMDB Compounds for MINPP1 Gene

Compound Synonyms Cas Number PubMed IDs
Inositol 1,3,4,5-tetraphosphate
  • 1,3,4,5-tetrakis(dihydrogen phosphate) myo-Inositol
102850-29-3
Inositol 1,4,5-trisphosphate
  • 1D-myo-Inositol 1,4,5-trisphosphate
88269-39-0
Myo-inositol hexakisphosphate
  • 1D-myo-Inositol 1,2,3,4,5,6-hexakisphosphate
83-86-3
Phosphate
  • NFB Orthophosphate
14265-44-2
Water
  • Dihydrogen oxide
7732-18-5

(2) Novoseek inferred chemical compound relationships for MINPP1 Gene

Compound -log(P) Hits PubMed IDs
phytate 67.7 2
inositol 54.8 1
genes like me logo Genes that share compounds with MINPP1: view

Transcripts for MINPP1 Gene

Unigene Clusters for MINPP1 Gene

Multiple inositol-polyphosphate phosphatase 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MINPP1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MINPP1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c
SP1: -
SP2:
SP3: - -
SP4:

Relevant External Links for MINPP1 Gene

GeneLoc Exon Structure for
MINPP1
ECgene alternative splicing isoforms for
MINPP1

Expression for MINPP1 Gene

mRNA expression in normal human tissues for MINPP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MINPP1 Gene

SOURCE GeneReport for Unigene cluster for MINPP1 Gene Hs.121260

mRNA Expression by UniProt/SwissProt for MINPP1 Gene

Q9UNW1-MINP1_HUMAN
Tissue specificity: Widely expressed with highest levels in kidney, liver and placenta.
genes like me logo Genes that share expressions with MINPP1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for MINPP1 Gene

Orthologs for MINPP1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MINPP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MINPP1 35
  • 99.11 (n)
  • 98.77 (a)
MINPP1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MINPP1 35
  • 88.61 (n)
  • 87.24 (a)
MINPP1 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MINPP1 35
  • 88.56 (n)
  • 91.61 (a)
MINPP1 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Minpp1 35
  • 81.7 (n)
  • 83.16 (a)
Minpp1 16
Minpp1 36
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MINPP1 36
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MINPP1 36
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Minpp1 35
  • 82.88 (n)
  • 84.2 (a)
chicken
(Gallus gallus)
Aves MINPP1 35
  • 66.43 (n)
  • 61.63 (a)
MINPP1 36
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MINPP1 36
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia minpp1 35
  • 59.95 (n)
  • 56.52 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.485 35
zebrafish
(Danio rerio)
Actinopterygii minpp1a 36
  • 44 (a)
OneToMany
minpp1b 35
  • 55.09 (n)
  • 48.38 (a)
minpp1b 36
  • 45 (a)
OneToMany
zgc56080 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003555 35
  • 43.47 (n)
  • 29.44 (a)
fruit fly
(Drosophila melanogaster)
Insecta Mipp1 36
  • 24 (a)
OneToMany
Mipp2 35
  • 42.43 (n)
  • 30 (a)
Mipp2 36
  • 26 (a)
OneToMany
Mipp2 37
  • 26 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PHO11 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G09870 35
  • 42.09 (n)
  • 28.91 (a)
rice
(Oryza sativa)
Liliopsida Os03g0818100 35
  • 43.56 (n)
  • 28.57 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 38 (a)
OneToOne
Species with no ortholog for MINPP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MINPP1 Gene

ENSEMBL:
Gene Tree for MINPP1 (if available)
TreeFam:
Gene Tree for MINPP1 (if available)

Paralogs for MINPP1 Gene

No data available for Paralogs for MINPP1 Gene

Variants for MINPP1 Gene

Sequence variations from dbSNP and Humsavar for MINPP1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs942422 -- 87,550,570(+) TTACA(C/T)GCTTT intron-variant
rs1063692 -- 87,505,359(+) GTAGA(A/G)AAGGG synonymous-codon, reference
rs1408377 -- 87,550,905(+) ACTCA(C/T)CAAGT intron-variant
rs2233162 -- 87,504,496(+) GTGCT(A/G)TTTTG utr-variant-5-prime
rs2233163 -- 87,504,564(+) CACAC(C/T)CAAAA utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for MINPP1 Gene

Variant ID Type Subtype PubMed ID
dgv310e1 CNV Complex 17122850
nsv428236 CNV Loss 18775914
dgv315e1 CNV Complex 17122850
essv7646 CNV CNV 17122850
esv26704 CNV Gain+Loss 19812545
nsv510993 CNV Complex 20534489
nsv511458 CNV Loss 21212237
nsv512173 CNV Loss 21212237
dgv166n67 CNV Gain 20364138
nsv825496 CNV Loss 20364138
nsv820304 CNV Gain 19587683
esv2739239 CNV Deletion 23290073
esv1003677 CNV Loss 20482838
nsv825497 CNV Gain 20364138
nsv821205 CNV Deletion 20802225
nsv825499 CNV Loss 20364138
esv2657019 CNV Deletion 23128226
nsv508598 CNV Loss 20534489
nsv819899 CNV Loss 19587683

Relevant External Links for MINPP1 Gene

HapMap Linkage Disequilibrium report
MINPP1
Human Gene Mutation Database (HGMD)
MINPP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MINPP1 Gene

Disorders for MINPP1 Gene

(1) OMIM Diseases for MINPP1 Gene (605391)

UniProtKB/Swiss-Prot

MINP1_HUMAN
  • Note=Defects in MINPP1 may be involved in follicular thyroid tumors development.

(1) University of Copenhagen DISEASES for MINPP1 Gene

(1) Novoseek inferred disease relationships for MINPP1 Gene

Disease -log(P) Hits PubMed IDs
tumors 0 3

Relevant External Links for MINPP1

Genetic Association Database (GAD)
MINPP1
Human Genome Epidemiology (HuGE) Navigator
MINPP1
genes like me logo Genes that share disorders with MINPP1: view

Publications for MINPP1 Gene

  1. Multiple inositol polyphosphate phosphatase: evolution as a distinct group within the histidine phosphatase family and chromosomal localization of the human and mouse genes to chromosomes 10q23 and 19. (PMID: 10087200) Chi H. … Reynolds P.R. (Genomics 1999) 2 3 4 23
  2. Somatic mutation and germline variants of MINPP1, a phosphatase gene located in proximity to PTEN on 10q23.3, in follicular thyroid carcinomas. (PMID: 11297621) Gimm O. … Eng C. (J. Clin. Endocrinol. Metab. 2001) 3 4 23
  3. The human and rat forms of multiple inositol polyphosphate phosphatase: functional homology with a histidine acid phosphatase up- regulated during endochondral ossification. (PMID: 9923613) Caffrey J.J. … Shears S.B. (FEBS Lett. 1999) 3 4 23
  4. A meta-analysis of four genome-wide association studies of survival to age 90 years or older: the Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium. (PMID: 20304771) Newman A.B. … Murabito J.M. (J. Gerontol. A Biol. Sci. Med. Sci. 2010) 3 48
  5. Cloning and characterization of ectopically expressed transcripts for the actin-binding protein MIPP in mouse mammary carcinomas. (PMID: 11536049) VanHouten J.N. … Asch B.B. (Oncogene 2001) 3 23

Products for MINPP1 Gene

Sources for MINPP1 Gene

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