Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



MINPP1 Gene

protein-coding   GIFtS: 68
GCID: GC10P089264

Multiple Inositol-Polyphosphate Phosphatase 1

(Previous names: multiple inositol polyphosphate histidine phosphatase, 1)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Multiple Inositol-Polyphosphate Phosphatase 11 2     EC 3.1.3.623 8
Multiple Inositol Polyphosphate Histidine Phosphatase, 11 2     HIPER12 5
Inositol (1,3,4,5)-Tetrakisphosphate 3-Phosphatase2 3     MINPP22
Ins(1,3,4,5)P(4) 3-Phosphatase2 3     Multiple Inositol Polyphosphate Phosphatase 12
2,3-Bisphosphoglycerate 3-Phosphatase2 3     Multiple Inositol Polyphosphate Phosphatase 22
2,3-BPG Phosphatase2 3     EC 3.1.3.803
MIPP2 3     

External Ids:    HGNC: 71021   Entrez Gene: 95622   Ensembl: ENSG000001077897   OMIM: 6053915   UniProtKB: Q9UNW13   

Export aliases for MINPP1 gene to outside databases

Previous GC identifers: GC10P088146 GC10P088486 GC10P089395 GC10P088929 GC10P089254 GC10P082898


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for MINPP1 Gene:
This gene encodes multiple inositol polyphosphate phosphatase; an enzyme that removes 3-phosphate from inositol
phosphate substrates. It is the only enzyme known to hydrolzye inositol pentakisphosphate and inositol
hexakisphosphate. This enzyme also converts 2,3 bisphosphoglycerate (2,3-BPG) to 2-phosphoglycerate; an activity
formerly thought to be exclusive to 2,3-BPG synthase/2-phosphatase (BPGM) in the Rapoport-Luebering shunt of the
glycolytic pathway.(provided by RefSeq, Sep 2009)

GeneCards Summary for MINPP1 Gene:
MINPP1 (multiple inositol-polyphosphate phosphatase 1) is a protein-coding gene. Diseases associated with MINPP1 include follicular thyroid carcinoma, and bannayan-riley-ruvalcaba syndrome. GO annotations related to this gene include bisphosphoglycerate 3-phosphatase activity and acid phosphatase activity.

UniProtKB/Swiss-Prot: MINP1_HUMAN, Q9UNW1
Function: Acts as a phosphoinositide 5- and phosphoinositide 6-phosphatase and regulates cellular levels of
inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6). Also acts as a 2,3-bisphosphoglycerate
3-phosphatase, by mediating the dephosphorylation of 2,3-bisphosphoglycerate (2,3-BPG) to produce
phospho-D-glycerate without formation of 3-phosphoglycerate. May play a role in bone development (endochondral
ossification)

Gene Wiki entry for MINPP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000010.11  NT_030059.14  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MINPP1 gene promoter:
         AML1a   Tal-1   Lmo2   Nkx2-5   E47   FOXL1   HEN1   POU2F1   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMINPP1 promoter sequence
   Search Chromatin IP Primers for MINPP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MINPP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q23   Ensembl cytogenetic band:  10q23.2   HGNC cytogenetic band: 10q23

MINPP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MINPP1 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P089264:  view genomic region     (about GC identifiers)

Start:
89,264,223 bp from pter      End:
89,313,218 bp from pter
Size:
48,996 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: MINP1_HUMAN, Q9UNW1 (See protein sequence)
Recommended Name: Multiple inositol polyphosphate phosphatase 1 precursor  
Size: 487 amino acids; 55051 Da
Sequence caution: Sequence=BAD93056.1; Type=Erroneous initiation;
Secondary accessions: F5H683 O95172 O95286 Q59EJ2 Q9UGA3
Alternative splicing: 4 isoforms:  Q9UNW1-1   Q9UNW1-2   Q9UNW1-3   Q9UNW1-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MINPP1: NX_Q9UNW1

Explore proteomics data for MINPP1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Ser42, Asn242, Asn481
  • Modification sites at PhosphoSitePlus
  • 3 DME Specific Peptides for MINPP1 (Q9UNW1)
     NDKLMRFFDHCEKFLT  TALYHVEAFKTGPEMQ  CTPVQLVALIRHGTRYPT 


    See MINPP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001171588.1  NP_001171589.1  NP_004888.2  

    ENSEMBL proteins: 
     ENSP00000361064   ENSP00000361062   ENSP00000437823  
    Reactome Protein details: Q9UNW1

    MINPP1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for MINPP1
    OriGene Protein Over-expression Lysate for MINPP1
    OriGene MassSpec for MINPP1
    OriGene Custom Protein Services for MINPP1
    GenScript Custom Purified and Recombinant Proteins Services for MINPP1
    Novus Biologicals MINPP1 Protein
    Novus Biologicals MINPP1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MINPP1

    MINPP1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for MINPP1
    OriGene Custom Antibody Services for MINPP1
    Novus Biologicals MINPP1 Antibodies
    Abcam antibodies for MINPP1
    Cloud-Clone Corp. Antibodies for MINPP1
    ThermoFisher Antibody for MINPP1
    LSBio Antibodies in human, mouse, rat for MINPP1

    MINPP1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MINPP1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MINPP1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MINPP1
    Cloud-Clone Corp. CLIAs for MINPP1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    2 InterPro protein domains:
     IPR000560 His_Pase_superF_clade-2
     IPR016274 Histidine_acid_Pase_euk

    Graphical View of Domain Structure for InterPro Entry Q9UNW1

    ProtoNet protein and cluster: Q9UNW1

    1 Blocks protein domain: IPB000560 Histidine acid phosphatase

    UniProtKB/Swiss-Prot: MINP1_HUMAN, Q9UNW1
    Similarity: Belongs to the histidine acid phosphatase family. MINPP1 subfamily


    MINPP1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MINP1_HUMAN, Q9UNW1
    Function: Acts as a phosphoinositide 5- and phosphoinositide 6-phosphatase and regulates cellular levels of
    inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6). Also acts as a 2,3-bisphosphoglycerate
    3-phosphatase, by mediating the dephosphorylation of 2,3-bisphosphoglycerate (2,3-BPG) to produce
    phospho-D-glycerate without formation of 3-phosphoglycerate. May play a role in bone development (endochondral
    ossification)
    Catalytic activity: Myo-inositol hexakisphosphate + H(2)O = myo-inositol pentakisphosphate (mixed isomers) +
    phosphate
    Catalytic activity: 2,3-bisphospho-D-glycerate + H(2)O = 2-phospho-D-glycerate + phosphate
    Biophysicochemical properties: Kinetic parameters: KM=0.61 mM for 2,3-bisphosphoglycerate; Vmax=15.8 nmol/min/mg
    enzyme with 2,3-bisphospho-D-glycerate as substrate;

         Genatlas biochemistry entry for MINPP1:
    multiple inositol polyphosphate phosphatase 1,belonging to a distinct group of histidine phosphatase

         Enzyme Numbers (IUBMB): EC 3.1.3.621 2 EC 3.1.3.801

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003993acid phosphatase activity IEA--
    GO:0008969phosphohistidine phosphatase activity TAS10087200
    GO:0016791phosphatase activity ----
    GO:0034417bisphosphoglycerate 3-phosphatase activity IDA18413611
    GO:0052826inositol hexakisphosphate 2-phosphatase activity IEA--
         
    MINPP1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for MINPP1:
     Decreased Salmonella enterica   Decreased focal adhesion (FA)  

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Minpp1):
     normal 

    MINPP1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Minpp1tm1Prr for MINPP1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MINPP1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MINPP1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MINPP1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MINPP1

    miRNA
    Products:
        
    miRTarBase miRNAs that target MINPP1:
    hsa-mir-374b-5p (MIRT016067), hsa-mir-454-5p (MIRT039251), hsa-mir-340-5p (MIRT019569), hsa-mir-1 (MIRT023881)

    Block miRNA regulation of human, mouse, rat MINPP1 using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate MINPP1:
    hsa-miR-30c hsa-miR-3607-3p hsa-miR-30a hsa-miR-30b hsa-miR-30d hsa-miR-30e
    SwitchGear 3'UTR luciferase reporter plasmidMINPP1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MINPP1
    Predesigned siRNA for gene silencing in human, mouse, rat MINPP1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MINPP1

    Clone
    Products:
         
    OriGene clones in human, mouse for MINPP1 (see all 14)
    OriGene ORF clones in mouse, rat for MINPP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): MINPP1 (NM_004897)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MINPP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MINPP1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MINPP1
    Browse ESI BIO Cell Lines and PureStem Progenitors for MINPP1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MINPP1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    MINP1_HUMAN, Q9UNW1: Endoplasmic reticulum lumen (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum4
    extracellular2
    mitochondrion2
    cytosol1
    lysosome1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum TAS10087200
    GO:0005788endoplasmic reticulum lumen TAS--

    MINPP1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for MINPP1 About    
    See pathways by source

    SuperPathContained pathways About
    1Inositol phosphate metabolism (KEGG)
    Inositol phosphate metabolism0.61
    superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism0.00
    superpathway of inositol phosphate compounds0.60
    D-myo-inositol (1,3,4)-trisphosphate biosynthesis0.00
    2Inositol phosphate metabolism (REACTOME)
    Inositol phosphate metabolism0.59
    D-myo-inositol (1,4,5,6)-tetrakisphosphate biosynthesis0.00
    Synthesis of IPs in the ER lumen0.00
    3Metabolism
    Metabolism0.38
    4Rapoport-Luebering glycolytic shunt
    Rapoport-Luebering glycolytic shunt

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5 BioSystems Pathways for MINPP1
        D-myo-inositol (1,3,4)-trisphosphate biosynthesis
    Rapoport-Luebering glycolytic shunt
    D-myo-inositol (1,4,5,6)-tetrakisphosphate biosynthesis
    superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism
    superpathway of inositol phosphate compounds

    1 Reactome Pathway for MINPP1
        Synthesis of IPs in the ER lumen


    1 Kegg Pathway  (Kegg details for MINPP1):
        Inositol phosphate metabolism


    MINPP1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MINPP1
    Interactions:

        Search GeneGlobe Interaction Network for MINPP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MINPP1 (Q9UNW13 ENSP000003610644) via UniProtKB, MINT, STRING, and/or I2D (see all 57)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ACTA1P681333, ENSP000003556454I2D: score=2 STRING: ENSP00000355645
    SRFP118313, ENSP000002653544I2D: score=1 STRING: ENSP00000265354
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    BPGMENSP000003420324STRING: ENSP00000342032
    ITPK1ENSP000002676154STRING: ENSP00000267615
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001503ossification NAS9923613
    GO:0006797polyphosphate metabolic process TAS10087200
    GO:0016311dephosphorylation TAS10087200
    GO:0030282bone mineralization NAS9923613
    GO:0043647inositol phosphate metabolic process TAS--

    MINPP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MINPP1 (MINP1)

    5 HMDB Compounds for MINPP1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Inositol 1,3,4,5-tetraphosphate1,3,4,5-tetrakis(dihydrogen phosphate) myo-Inositol (see all 16)102850-29-3--
    Inositol 1,4,5-trisphosphate1D-myo-Inositol 1,4,5-trisphosphate (see all 4)88269-39-0--
    Myo-inositol hexakisphosphate1D-myo-Inositol 1,2,3,4,5,6-hexakisphosphate (see all 9)83-86-3--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    2 Novoseek inferred chemical compound relationships for MINPP1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    phytate 67.7 2 15979280 (2)
    inositol 54.8 1 9923613 (1)



    MINPP1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for MINPP1 gene (3 alternative transcripts): 
    NM_001178117.1  NM_001178118.1  NM_004897.4  

    Unigene Cluster for MINPP1:

    Multiple inositol-polyphosphate phosphatase 1
    Hs.121260  [show with all ESTs]
    Unigene Representative Sequence: NM_004897
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000371996(uc001keu.3 uc009xtf.2) ENST00000371994(uc001kev.3)
    ENST00000472891 ENST00000536010(uc021pvv.1)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MINPP1 using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate MINPP1:
    hsa-miR-30c hsa-miR-3607-3p hsa-miR-30a hsa-miR-30b hsa-miR-30d hsa-miR-30e
    SwitchGear 3'UTR luciferase reporter plasmidMINPP1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MINPP1
    Predesigned siRNA for gene silencing in human, mouse, rat MINPP1
    Clone
    Products:
         
    OriGene clones in human, mouse for MINPP1 (see all 14)
    OriGene ORF clones in mouse, rat for MINPP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): MINPP1 (NM_004897)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MINPP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MINPP1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for MINPP1
    OriGene qSTAR qPCR primer pairs in human, mouse for MINPP1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MINPP1
      QuantiTect SYBR Green Assays in human, mouse, rat MINPP1
      QuantiFast Probe-based Assays in human, mouse, rat MINPP1

    Additional mRNA sequence: 

    AB209819.1 AF046914.1 AF084943.1 AF084944.1 AK304624.1 AK309176.1 AK312937.1 AL050356.1 
    AY358938.1 BC032504.1 

    6 DOTS entries:

    DT.410746  DT.100817951  DT.100817947  DT.100817952  DT.100817954  DT.121249170 

    Selected AceView cDNA sequences (see all 117):

    BX280983 CB240630 BX351615 AF084944 AF084943 AU279759 BU625626 AI474316 
    AW243689 BG431150 AA315402 BQ003601 BC032504 CA442671 BQ575074 F10100 
    Z44288 AA878054 BX396922 CR595009 BQ004246 BX494748 AW827102 BQ002769 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for MINPP1    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c
    SP1:                                      -                     
    SP2:                                                            
    SP3:                    -                 -                     
    SP4:                                                            


    ECgene alternative splicing isoforms for MINPP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    MINPP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAATGTAAGA
    MINPP1 Expression
    About this image


    MINPP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Kidney (Urinary System)
             Metanephros
    MINPP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MINPP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.121260

    UniProtKB/Swiss-Prot: MINP1_HUMAN, Q9UNW1
    Tissue specificity: Widely expressed with highest levels in kidney, liver and placenta

        Custom PCR Arrays for MINPP1
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for MINPP1
    OriGene qSTAR qPCR primer pairs in human, mouse for MINPP1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MINPP1
    QuantiTect SYBR Green Assays in human, mouse, rat MINPP1
    QuantiFast Probe-based Assays in human, mouse, rat MINPP1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MINPP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MINPP1 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Minpp11 , 5 multiple inositol polyphosphate histidine phosphatase more1, 5 81.7(n)1
    83.16(a)1
      19 (27.25 cM)5
    173301  NM_010799.21  NP_034929.11 
     324857695 
    chicken
    (Gallus gallus)
    Aves MINPP11 multiple inositol-polyphosphate phosphatase 1 66.43(n)
    61.63(a)
      395356  NM_204644.1  NP_989975.1 
    lizard
    (Anolis carolinensis)
    Reptilia MINPP16
    multiple inositol-polyphosphate phosphatase 1
    49(a)
    1 ↔ 1
    GL343246.1(1154804-1173553)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia minpp11 multiple inositol-polyphosphate phosphatase 1 59.95(n)
    56.52(a)
      100493648  XM_002935426.2  XP_002935472.2 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc560802 similar to multiple inositol polyphosphate histidine more 74.82(n)   394075  BC047824.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Mipp21 , 3 inositol/phosphatidylinositol
    phosphatase3
    Multiple inositol polyphosphate phosphatase 21
    26(a)3
    42.43(n)1
    30(a)1
      5D43
    315441  NM_078500.41  NP_511055.11 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G098701 AT1G09870 42.09(n)
    28.91(a)
      837519  NM_100861.3  NP_563856.1 
    rice
    (Oryza sativa)
    Liliopsida Os03g08181001 Os03g0818100 43.56(n)
    28.57(a)
      4334577  NM_001058240.1  NP_001051705.1 


    ENSEMBL Gene Tree for MINPP1 (if available)
    TreeFam Gene Tree for MINPP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for MINPP1 (see all 935)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0228364
    A follicular thyroid carcinoma4--see VAR_0228362 S L mis40--------
    rs1048941711,2
    Cpathogenic189639867(+) TTTGCA/GAGTGC 6 Q R mis10--------
    rs57867761,2
    C--89267253(+) TTTTTT/-GCATA 3 -- int1 us2k12Minor allele frequency- -:0.00NA CSA 4
    rs710194821,2
    C--89275580(-) AAAAA-/ATTCTT 3 -- int11Minor allele frequency- A:0.00NA 2
    rs755714421,2
    F--89282525(+) AAAATA/GTCAAT 3 -- int11Minor allele frequency- G:0.02EA 120
    rs764063971,2
    --89282785(+) GTGTTC/TAAGTT 3 -- int10--------
    rs347679421,2
    C--89283114(+) TTCTG-/TTTTTT 3 -- int12Minor allele frequency- T:0.25NA 4
    rs570912211,2
    C--89283275(+) TTTTT-/TGTATT 3 -- int11Minor allele frequency- T:0.00NA 2
    rs1130690761,2
    C,F--89284438(+) GGCCAC/TTGTAG 3 -- int11Minor allele frequency- T:0.50NA 2
    rs770818131,2
    F--89288003(+) CTTCTG/ACTAGC 3 -- int11Minor allele frequency- A:0.50NA 2

    HapMap Linkage Disequilibrium report for MINPP1 (89264223 - 89313218 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for MINPP1 (see all 19):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2657019CNV Deletion23128226
    nsv821205CNV Deletion20802225
    esv2739239CNV Deletion23290073
    esv1003677CNV Loss20482838
    nsv825499CNV Loss20364138
    nsv508598CNV Loss20534489
    nsv512173CNV Loss21212237
    nsv825496CNV Loss20364138
    nsv428236CNV Loss18775914
    nsv511458CNV Loss21212237

    Human Gene Mutation Database (HGMD): MINPP1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MINPP1
    DNA2.0 Custom Variant and Variant Library Synthesis for MINPP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 605391   
    OMIM disorders: 188470  
    UniProtKB/Swiss-Prot: MINP1_HUMAN, Q9UNW1
  • Note=Defects in MINPP1 may be involved in follicular thyroid tumors development

  • 13 diseases for MINPP1:    
    About MalaCards
    follicular thyroid carcinoma    bannayan-riley-ruvalcaba syndrome    ruvalcaba syndrome    cowden disease
    labyrinthitis    fanconi's anemia    thyroiditis    alzheimer's disease
    prostate cancer    multiple myeloma    prostatitis    malaria
    myeloma

    1 disease from the University of Copenhagen DISEASES database for MINPP1:
    Bannayan-Riley-Ruvalcaba syndrome

    MINPP1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    1 Novoseek inferred disease relationship for MINPP1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 5 11297621 (3)

    Genetic Association Database (GAD): MINPP1
    Human Genome Epidemiology (HuGE) Navigator: MINPP1 (3 documents)

    Export disorders for MINPP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for MINPP1 gene, integrated from 10 sources (see all 28):
    (articles sorted by number of sources associating them with MINPP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Multiple inositol polyphosphate phosphatase: evolution as a distinct group within the histidine phosphatase family and chromosomal localization of the human and mouse genes to chromosomes 10q23 and 19. (PubMed id 10087200)1, 2, 3, 9 Chi H.... Reynolds P.R. (Genomics 1999)
    2. Somatic mutation and germline variants of MINPP1, a phosphatase gene located in proximity to PTEN on 10q23.3, in follicular thyroid carcinomas. (PubMed id 11297621)1, 2, 9 Gimm O.... Eng C. (J. Clin. Endocrinol. Metab. 2001)
    3. The human and rat forms of multiple inositol polyphosphate phosphatase: functional homology with a histidine acid phosphatase up- regulated during endochondral ossification. (PubMed id 9923613)1, 2, 9 Caffrey J.J.... Shears S.B. (FEBS Lett. 1999)
    4. A meta-analysis of four genome-wide association studies of survival to age 90 years or older: the Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium. (PubMed id 20304771)1, 4 Newman A.B....Murabito J.M. (J. Gerontol. A Biol. Sci. Med. Sci. 2010)
    5. Dephosphorylation of 2,3-bisphosphoglycerate by MIPP expands the regulatory capacity of the Rapoport-Luebering glycolytic shunt. (PubMed id 18413611)1, 2 Cho J.... Shears S.B. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    6. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (Am. J. Hum. Genet. 2006)
    7. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (J. Proteome Res. 2005)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (Nature 2004)
    10. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 9562 HGNC: 7102 AceView: MINPP1 Ensembl:ENSG00000107789 euGenes: HUgn9562
    ECgene: MINPP1 Kegg: 9562 H-InvDB: MINPP1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for MINPP1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MINPP1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for MINPP1 gene:
    Search GeneIP for patents involving MINPP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for MINPP1   OriGene RNAi products in human, mouse, rat for MINPP1  
     OriGene qPCR primer pairs and template standards for MINPP1   OriGene Protein Over-expression Lysate for MINPP1  
     OriGene MassSpec something-or-other for MINPP1   OriGene clones in human, mouse for MINPP1  
     OriGene qSTAR qPCR primer pairs in human, mouse for MINPP1   OriGene Purified Protein for MINPP1  
     OriGene ORF clones in mouse, rat for MINPP1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for MINPP1   OriGene Custom Protein Services for MINPP1  

     
     
     Block miRNA regulation of human, mouse, rat MINPP1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing MINPP1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MINPP1 Predesigned siRNA for gene silencing in human, mouse, rat MINPP1
     QuantiFast Probe-based Assays in human, mouse, rat MINPP1 QuantiTect SYBR Green Assays in human, mouse, rat MINPP1
     Custom PCR Arrays for MINPP1 Search Chromatin IP Primers for MINPP1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MINPP1  Search GeneGlobe Interaction Network for MINPP1
     Regulatory tfbs in MINPP1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for MINPP1 GenScript cDNA clones with any tag delivered in your preferred vector for MINPP1
     GenScript Custom Assay Services for MINPP1 GenScript Custom overexpressing Cell Line Services for MINPP1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for MINPP1 (MINP1)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     MINPP1 antibodies
     MINPP1 proteins
     MINPP1 lysates
     Antibodies for MINPP1
     See all of Abcam's Antibodies, Kits and Proteins for MINPP1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for MINPP1
     Antibodies for MINPP1
     ELISAs for MINPP1
     CLIAs for MINPP1



     Browse ESI BIO Cell Lines and PureStem Progenitors for MINPP1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MINPP1
     SwitchGear 3'UTR luciferase reporter plasmids for MINPP1
     SwitchGear Promoter luciferase reporter plasmids for MINPP1
     ThermoFisher Antibody for MINPP1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MINPP1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MINPP1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MINPP1
     LSBio Antibodies in human, mouse, rat for MINPP1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      MINPP1 gene at Home site.
    Version: 3.12.142 28 July 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4