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MINOS1-NBL1 Gene

protein-coding   GIFtS: 20
GCID: GC01P019925

MINOS1-NBL1 Readthrough

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
MINOS1-NBL1 Readthrough1 2
C1orf151-NBL12
C1orf151-NBL1 Read-Through Protein2

External Ids:    HGNC: 483381   Entrez Gene: 1005327362   Ensembl: ENSG000002701367   UniProtKB: R4GMM14   UniProtKB: R4GMY44   
UniProtKB: R4GNA14   
ORGUL members:         

Export aliases for MINOS1-NBL1 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MINOS1-NBL1 Gene:
This locus represents naturally occurring read-through transcription between the neighboring chromosome 1 open
reading frame 151 (GeneID 440574) and neuroblastoma suppressor of tumorigenicity 1 (GeneID 4681) genes on
chromosome 1. The read-through transcripts produce at least two proteins, each of which share identity with
proteins translated from the downstream neuroblastoma suppressor of tumorigenicity 1 locus. (provided by RefSeq,
Feb 2011)

GeneCards Summary for MINOS1-NBL1 Gene:
MINOS1-NBL1 (MINOS1-NBL1 readthrough) is a protein-coding gene. Diseases associated with MINOS1-NBL1 include neuroblastoma 1, and neuroblastoma. An important paralog of this gene is NBL1.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for MINOS1-NBL1
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MINOS1-NBL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.13   Ensembl cytogenetic band:  1p36.13   HGNC cytogenetic band: 1p36.13

MINOS1-NBL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MINOS1-NBL1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P019925:  view genomic region     (about GC identifiers)

Start:
19,923,471 bp from pter      End:
19,984,949 bp from pter
Size:
61,479 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/TrEMBL: R4GMM1 (See protein sequence)
Recommended Name: Protein MINOS1-NBL1  
Size: 46 amino acids; 5154 Da
Caution: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered
as preliminary data

UniProtKB/TrEMBL: R4GMY4 (See protein sequence)

Recommended Name: Protein MINOS1-NBL1  
Size: 114 amino acids; 12455 Da
Caution: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered
as preliminary data

UniProtKB/TrEMBL: R4GNA1 (See protein sequence)

Recommended Name: Protein MINOS1-NBL1  
Size: 71 amino acids; 8074 Da
Caution: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered
as preliminary data

REFSEQ proteins (2 alternative transcripts): 
NP_001191017.1  NP_001191018.1  

ENSEMBL proteins: 
 ENSP00000473411   ENSP00000473550   ENSP00000473403   ENSP00000473256  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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3 InterPro protein domains:
 IPR016728 Neuroblast_suppress_tumour_1
 IPR004133 DAN
 IPR007512 DUF543

Graphical View of Domain Structure for InterPro Entry R4GMM1
Graphical View of Domain Structure for InterPro Entry R4GMY4
Graphical View of Domain Structure for InterPro Entry R4GNA1

ProtoNet protein and cluster: R4GMM1


MINOS1-NBL1 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0016015morphogen activity ----
GO:0036122BMP binding ----
     
MINOS1-NBL1 for ontologies           About GeneDecksing


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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region ----
GO:0005739mitochondrion ----

MINOS1-NBL1 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MINOS1-NBL1
Interactions:

    Search GeneGlobe Interaction Network for MINOS1-NBL1

Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007399nervous system development ----
GO:0035582sequestering of BMP in extracellular matrix ----
GO:0045666positive regulation of neuron differentiation ----
GO:0048263determination of dorsal identity ----
GO:0048812neuron projection morphogenesis ----

MINOS1-NBL1 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for MINOS1-NBL1 gene (2 alternative transcripts): 
NM_001204088.1  NM_001204089.1  

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000602662 ENST00000602384 ENST00000602293 ENST00000602450
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GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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MINOS1-NBL1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
MINOS1-NBL1 Expression
About this image

MINOS1-NBL1 Protein expression data from MOPED1, PaxDb2 and MaxQB3 --
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In Situ
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MINOS1-NBL1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for MINOS1-NBL1 gene from Selected species (see all 8)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Nbl11 neuroblastoma, suppression of tumorigenicity 1 89.51(n)
93.82(a)
  17965  NM_008675.2  NP_032701.2 
chicken
(Gallus gallus)
Aves NBL11 neuroblastoma, suppression of tumorigenicity 1 79.31(n)
79.19(a)
  373952  NM_204149.1  NP_989480.1 
lizard
(Anolis carolinensis)
Reptilia --
Uncharacterized protein
61(a)
1 → many
GL344078.1(38851-58076)
tropical clawed frog
(Xenopus tropicalis)
Amphibia nbl11 neuroblastoma 1, DAN family BMP antagonist 80.15(n)
80.15(a)
  448558  NM_001006825.1  NP_001006826.1 
zebrafish
(Danio rerio)
Actinopterygii nbl11 neuroblastoma, suppression of tumorigenicity 1 69.39(n)
68.71(a)
  404629  NM_207097.1  NP_996980.1 


ENSEMBL Gene Tree for MINOS1-NBL1 (if available)
TreeFam Gene Tree for MINOS1-NBL1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for MINOS1-NBL1 gene
NBL11 2  
3 SIMAP similar genes for MINOS1-NBL1 using alignment to 3 protein entries:     R4GMM1_HUMAN (see all proteins):
MINOS1    NBL1    GREM1

MINOS1-NBL1 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for MINOS1-NBL1 (see all 234)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 1 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1405898951,2
C--19957089(+) AAAACA/C/TACACA 2 -- int10--------
rs360968541,2
C--19957112(+) CACAC-/ACACACA 2 -- int11Minor allele frequency- AC:0.50NA 2
rs671442181,2
C--19957122(+) CACAC-/AC    
   
/CACT
TTATT
2 -- int12NA CSA 4
rs1145854541,2
F--19957122(+) CACACA/TCTTAT 2 -- int12Minor allele frequency- T:0.06NA EA 240
rs357961341,2
C,F--19957125(+) ACACTT/CATTTA 2 -- int15Minor allele frequency- C:0.15NA CSA WA EA 362
rs1896363151,2
--19957233(+) AACTAC/TTACTG 2 -- int10--------
rs1815299191,2
--19957257(+) AGGATA/TATTGG 2 -- int10--------
rs1862228891,2
--19957343(+) AAGGAA/GGAGTG 2 -- int10--------
rs1906952151,2
--19957436(+) TTCCCC/GGTCCA 2 -- int10--------
rs580552351,2
F--19957512(+) CTATTA/CTCCTC 2 -- int11Minor allele frequency- C:0.02WA 118

HapMap Linkage Disequilibrium report for MINOS1-NBL1 (19923471 - 19984949 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for MINOS1-NBL1: --
Site Specific Mutation Identification with PCR Assays
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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3 diseases for MINOS1-NBL1:    
About MalaCards
neuroblastoma 1    neuroblastoma    neuronitis


MINOS1-NBL1 for disorders           About GeneDecksing


Export disorders for MINOS1-NBL1 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed article for MINOS1-NBL1 gene integrated from 10 sources:
(articles sorted by number of sources associating them with MINOS1-NBL1)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PubMed id 20967262)1 Prakash T....Taylor T.D. (PLoS ONE 2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 100532736 HGNC: 48338 Ensembl:ENSG00000270136 euGenes: HUgn100532736 ECgene: MINOS1-NBL1
H-InvDB: MINOS1-NBL1

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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  --

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for MINOS1-NBL1 gene:
Search GeneIP for patents involving MINOS1-NBL1

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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