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Aliases for MINOS1-NBL1 Gene

Aliases for MINOS1-NBL1 Gene

  • MINOS1-NBL1 Readthrough 2 3 5
  • C1orf151-NBL1 Read-Through Protein 3
  • C1orf151-NBL1 3

External Ids for MINOS1-NBL1 Gene

Previous GeneCards Identifiers for MINOS1-NBL1 Gene

  • GC01P019925

Summaries for MINOS1-NBL1 Gene

Entrez Gene Summary for MINOS1-NBL1 Gene

  • This locus represents naturally occurring read-through transcription between the neighboring chromosome 1 open reading frame 151 (GeneID 440574) and neuroblastoma suppressor of tumorigenicity 1 (GeneID 4681) genes on chromosome 1. The read-through transcripts produce at least two proteins, each of which share identity with proteins translated from the downstream neuroblastoma suppressor of tumorigenicity 1 locus. [provided by RefSeq, Feb 2011]

GeneCards Summary for MINOS1-NBL1 Gene

MINOS1-NBL1 (MINOS1-NBL1 Readthrough) is a Protein Coding gene. Among its related pathways are TGF-beta signaling pathway. GO annotations related to this gene include protein homodimerization activity and morphogen activity. An important paralog of this gene is NBL1.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MINOS1-NBL1 Gene

Genomics for MINOS1-NBL1 Gene

Regulatory Elements for MINOS1-NBL1 Gene

Enhancers for MINOS1-NBL1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F019599 1.3 FANTOM5 Ensembl 0.8 +2.8 2825 1.6 ELF3 MLX ARID4B DMAP1 RAD21 THRB ZNF48 RARA SLC30A9 GATA4 NBL1 AKR7A2 TMCO4 MINOS1 MINOS1-NBL1 RPS14P3
GH01F019595 1.1 ENCODE 0.8 +0.1 113 3.4 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 MUL1 NBL1 AKR7A2 MINOS1 MINOS1-NBL1 RPS14P3
GH01F019605 0.4 Ensembl 0.4 +9.3 9324 1.0 ZNF316 ZNF143 NBL1 AKR7A2 RPS14P3 MINOS1 MINOS1-NBL1
GH01F019606 0.4 ENCODE 0.4 +10.0 10025 0.2 ZNF316 TCF7 RPS14P3 MINOS1 MINOS1-NBL1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MINOS1-NBL1 on UCSC Golden Path with GeneCards custom track

Promoters for MINOS1-NBL1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001517994 323 2201 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1

Genomic Location for MINOS1-NBL1 Gene

Chromosome:
1
Start:
19,596,977 bp from pter
End:
19,658,456 bp from pter
Size:
61,480 bases
Orientation:
Plus strand

Genomic View for MINOS1-NBL1 Gene

Genes around MINOS1-NBL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MINOS1-NBL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MINOS1-NBL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MINOS1-NBL1 Gene

Proteins for MINOS1-NBL1 Gene

  • Protein details for MINOS1-NBL1 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    R4GMM1
    Recommended name:
    Protein MINOS1-NBL1
    Protein Accession:
    R4GMM1

    Protein attributes for MINOS1-NBL1 Gene

    Size:
    46 amino acids
    Molecular mass:
    5154 Da
    Quaternary structure:
    No Data Available
  • Protein details for MINOS1-NBL1 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    R4GMY4
    Recommended name:
    MICOS complex subunit MIC10
    Protein Accession:
    R4GMY4

    Protein attributes for MINOS1-NBL1 Gene

    Size:
    70 amino acids
    Molecular mass:
    7931 Da
    Quaternary structure:
    • Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
  • Protein details for MINOS1-NBL1 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    R4GNA1
    Recommended name:
    MICOS complex subunit MIC10
    Protein Accession:
    R4GNA1

    Protein attributes for MINOS1-NBL1 Gene

    Size:
    71 amino acids
    Molecular mass:
    8074 Da
    Quaternary structure:
    • Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.

neXtProt entry for MINOS1-NBL1 Gene

Post-translational modifications for MINOS1-NBL1 Gene

No Post-translational modifications

Other Protein References for MINOS1-NBL1 Gene

No data available for DME Specific Peptides for MINOS1-NBL1 Gene

Domains & Families for MINOS1-NBL1 Gene

Protein Domains for MINOS1-NBL1 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MINOS1-NBL1: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MINOS1-NBL1 Gene

Function for MINOS1-NBL1 Gene

Animal Model Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MINOS1-NBL1 Gene

Localization for MINOS1-NBL1 Gene

Gene Ontology (GO) - Cellular Components for MINOS1-NBL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005743 mitochondrial inner membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0061617 MICOS complex IEA --
genes like me logo Genes that share ontologies with MINOS1-NBL1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for MINOS1-NBL1 Gene

Pathways & Interactions for MINOS1-NBL1 Gene

SuperPathways for MINOS1-NBL1 Gene

SuperPathway Contained pathways
1 TGF-beta signaling pathway
genes like me logo Genes that share pathways with MINOS1-NBL1: view

Pathways by source for MINOS1-NBL1 Gene

1 KEGG pathway for MINOS1-NBL1 Gene

Interacting Proteins for MINOS1-NBL1 Gene

Gene Ontology (GO) - Biological Process for MINOS1-NBL1 Gene

None

No data available for SIGNOR curated interactions for MINOS1-NBL1 Gene

Transcripts for MINOS1-NBL1 Gene

mRNA/cDNA for MINOS1-NBL1 Gene

(2) REFSEQ mRNAs :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MINOS1-NBL1 Gene

No ASD Table

Relevant External Links for MINOS1-NBL1 Gene

GeneLoc Exon Structure for
MINOS1-NBL1
ECgene alternative splicing isoforms for
MINOS1-NBL1

Expression for MINOS1-NBL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MINOS1-NBL1 Gene

genes like me logo Genes that share expression patterns with MINOS1-NBL1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MINOS1-NBL1 Gene

Orthologs for MINOS1-NBL1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MINOS1-NBL1 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia -- 35
  • 98 (a)
OneToMany
NBL1 34
  • 91.58 (n)
cow
(Bos Taurus)
Mammalia -- 35
  • 95 (a)
OneToMany
NBL1 34
  • 89.12 (n)
mouse
(Mus musculus)
Mammalia Nbl1 34 35
  • 89.51 (n)
rat
(Rattus norvegicus)
Mammalia Nbl1 34
  • 88.39 (n)
chicken
(Gallus gallus)
Aves NBL1 34 35
  • 79.31 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 61 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia nbl1 34
  • 80.15 (n)
zebrafish
(Danio rerio)
Actinopterygii nbl1 34
  • 69.39 (n)
NBL1 35
  • 52 (a)
OneToMany
Species where no ortholog for MINOS1-NBL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MINOS1-NBL1 Gene

ENSEMBL:
Gene Tree for MINOS1-NBL1 (if available)
TreeFam:
Gene Tree for MINOS1-NBL1 (if available)

Paralogs for MINOS1-NBL1 Gene

Paralogs for MINOS1-NBL1 Gene

(3) SIMAP similar genes for MINOS1-NBL1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with MINOS1-NBL1: view

Variants for MINOS1-NBL1 Gene

Sequence variations from dbSNP and Humsavar for MINOS1-NBL1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10489858 -- 19,620,762(+) TTTGA(C/T)TGAGT intron-variant
rs10489859 -- 19,621,312(+) GTGAA(C/G)ACTTG intron-variant
rs1049959 -- 19,657,853(+) CCAGA(A/G)GGAGG utr-variant-3-prime
rs1050027 -- 19,658,380(+) GGCTT(C/T)TGGAG utr-variant-3-prime
rs10569237 -- 19,647,863(+) TGTGT(-/GTGC)GTGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MINOS1-NBL1 Gene

Variant ID Type Subtype PubMed ID
esv1007512 OTHER inversion 20482838
esv2395760 CNV deletion 18987734
esv2665804 CNV deletion 23128226
esv3553344 CNV deletion 23714750
esv7640 CNV gain 19470904
nsv1011246 CNV gain 25217958
nsv1076211 CNV deletion 25765185
nsv1077188 CNV deletion 25765185
nsv1077193 CNV deletion 25765185
nsv1142753 CNV deletion 24896259
nsv1144359 CNV deletion 24896259
nsv954899 CNV deletion 24416366
nsv945809 CNV duplication 23825009
nsv545729 CNV loss 21841781
nsv508991 CNV insertion 20534489
nsv474503 CNV novel sequence insertion 20440878
nsv159533 CNV deletion 16902084
nsv1146286 CNV deletion 26484159

Variation tolerance for MINOS1-NBL1 Gene

Gene Damage Index Score: 0.66; 14.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MINOS1-NBL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MINOS1-NBL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MINOS1-NBL1 Gene

Disorders for MINOS1-NBL1 Gene

Relevant External Links for MINOS1-NBL1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MINOS1-NBL1

No disorders were found for MINOS1-NBL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MINOS1-NBL1 Gene

Publications for MINOS1-NBL1 Gene

  1. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T. … Taylor T.D. (PLoS ONE 2010) 3 64

Products for MINOS1-NBL1 Gene

Sources for MINOS1-NBL1 Gene

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