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Aliases for MINOS1 Gene

Aliases for MINOS1 Gene

  • Mitochondrial Inner Membrane Organizing System 1 2 3 5
  • Mitochondrial Inner Membrane Organizing System Protein 1 3 4
  • C1orf151 3 4
  • MIC10 3 4
  • Chromosome 1 Open Reading Frame 151 2
  • UPF0327 Protein C1orf151 3
  • RP5-1056L3.2 3
  • MIO10 3

External Ids for MINOS1 Gene

Previous HGNC Symbols for MINOS1 Gene

  • C1orf151

Previous GeneCards Identifiers for MINOS1 Gene

  • GC01P019924

Summaries for MINOS1 Gene

GeneCards Summary for MINOS1 Gene

MINOS1 (Mitochondrial Inner Membrane Organizing System 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for MINOS1 Gene

  • Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MINOS1 Gene

Genomics for MINOS1 Gene

Regulatory Elements for MINOS1 Gene

Promoters for MINOS1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MINOS1 on UCSC Golden Path with GeneCards custom track

Genomic Location for MINOS1 Gene

Chromosome:
1
Start:
19,596,977 bp from pter
End:
19,629,821 bp from pter
Size:
32,845 bases
Orientation:
Plus strand

Genomic View for MINOS1 Gene

Genes around MINOS1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MINOS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MINOS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MINOS1 Gene

Proteins for MINOS1 Gene

  • Protein details for MINOS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5TGZ0-MIC10_HUMAN
    Recommended name:
    MICOS complex subunit MIC10
    Protein Accession:
    Q5TGZ0
    Secondary Accessions:
    • Q96G68

    Protein attributes for MINOS1 Gene

    Size:
    78 amino acids
    Molecular mass:
    8808 Da
    Quaternary structure:
    • Component of the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MINOS1/MIC10, CHCHD3/MIC19, CHCHD6/MIC25, APOOL/MIC27, IMMT/MIC60, APOO/MIC23/MIC26 and QIL1/MIC13. This complex was also known under the names MINOS or MitOS complex. The MICOS complex associates with mitochondrial outer membrane proteins SAMM50, MTX1, MTX2 and DNAJC11, mitochondrial inner membrane protein TMEM11 and with HSPA9. Interacts with IMMT/MIC60 and QIL1/MIC13. Interacts with APOO/MIC23/MIC26 and APOOL/MIC27.
    SequenceCaution:
    • Sequence=AAH09927.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for MINOS1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MINOS1 Gene

Proteomics data for MINOS1 Gene at MOPED

Post-translational modifications for MINOS1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MINOS1 Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for MINOS1

No data available for DME Specific Peptides for MINOS1 Gene

Domains & Families for MINOS1 Gene

Protein Domains for MINOS1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MINOS1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5TGZ0

UniProtKB/Swiss-Prot:

MIC10_HUMAN :
  • Belongs to the MICOS complex subunit Mic10 family.
Family:
  • Belongs to the MICOS complex subunit Mic10 family.
genes like me logo Genes that share domains with MINOS1: view

No data available for Gene Families for MINOS1 Gene

Function for MINOS1 Gene

Molecular function for MINOS1 Gene

UniProtKB/Swiss-Prot Function:
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.

Gene Ontology (GO) - Molecular Function for MINOS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with MINOS1: view
genes like me logo Genes that share phenotypes with MINOS1: view

Animal Model Products

CRISPR Products

miRNA for MINOS1 Gene

miRTarBase miRNAs that target MINOS1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MINOS1 Gene

Localization for MINOS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MINOS1 Gene

Mitochondrion inner membrane; Single-pass membrane protein. Note=The C-terminus is located in the intermembrane space (By similarity), while the location of the N-terminus has not been determined yet. As some programs predict the presence of 2 closely apposed membrane domains, it has been proposed that the protein may cross the membrane twice and that both termini may face the intermembrane space (PubMed:22114354). {ECO:0000250, ECO:0000269 PubMed:22114354}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MINOS1 Gene COMPARTMENTS Subcellular localization image for MINOS1 gene
Compartment Confidence
mitochondrion 5
cytosol 2
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MINOS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA,IDA 20833797
genes like me logo Genes that share ontologies with MINOS1: view

Pathways & Interactions for MINOS1 Gene

SuperPathways for MINOS1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MINOS1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MINOS1 Gene

Drugs & Compounds for MINOS1 Gene

No Compound Related Data Available

Transcripts for MINOS1 Gene

Unigene Clusters for MINOS1 Gene

Mitochondrial inner membrane organizing system 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MINOS1 Gene

No ASD Table

Relevant External Links for MINOS1 Gene

GeneLoc Exon Structure for
MINOS1
ECgene alternative splicing isoforms for
MINOS1

Expression for MINOS1 Gene

mRNA expression in normal human tissues for MINOS1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MINOS1 Gene

This gene is overexpressed in Bone (16.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MINOS1 Gene



SOURCE GeneReport for Unigene cluster for MINOS1 Gene Hs.466662

genes like me logo Genes that share expression patterns with MINOS1: view

Protein tissue co-expression partners for MINOS1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MINOS1 Gene

Orthologs for MINOS1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MINOS1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MINOS1 35
  • 89.78 (n)
  • 94.67 (a)
dog
(Canis familiaris)
Mammalia MINOS1 35
  • 94.67 (n)
  • 94.67 (a)
MINOS1 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Minos1 35
  • 88.89 (n)
  • 93.33 (a)
Minos1 16
Minos1 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MINOS1 35
  • 99.05 (n)
  • 100 (a)
MINOS1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100361944 35
  • 88 (n)
  • 90.67 (a)
oppossum
(Monodelphis domestica)
Mammalia MINOS1 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MINOS1 36
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves MINOS1 35
  • 81.08 (n)
  • 82.43 (a)
MINOS1 36
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100135143 35
  • 72.97 (n)
  • 78.38 (a)
zebrafish
(Danio rerio)
Actinopterygii minos1 35
  • 66.67 (n)
  • 69.57 (a)
minos1 36
  • 66 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F54A3.5 36
  • 40 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MIC10 38
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5565 36
  • 27 (a)
OneToOne
Species with no ortholog for MINOS1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MINOS1 Gene

ENSEMBL:
Gene Tree for MINOS1 (if available)
TreeFam:
Gene Tree for MINOS1 (if available)

Paralogs for MINOS1 Gene

(1) SIMAP similar genes for MINOS1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MINOS1: view

No data available for Paralogs for MINOS1 Gene

Variants for MINOS1 Gene

Variation tolerance for MINOS1 Gene

Residual Variation Intolerance Score: 54.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.03; 0.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MINOS1 Gene

HapMap Linkage Disequilibrium report
MINOS1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Structural Variations from Database of Genomic Variants (DGV) for MINOS1 Gene

Disorders for MINOS1 Gene

Relevant External Links for MINOS1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MINOS1

No disorders were found for MINOS1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MINOS1 Gene

Publications for MINOS1 Gene

  1. The non-glycosylated isoform of MIC26 is a constituent of the mammalian MICOS complex and promotes formation of crista junctions. (PMID: 25764979) Koob S. … Reichert A.S. (Biochim. Biophys. Acta 2015) 3 4 67
  2. Dual role of mitofilin in mitochondrial membrane organization and protein biogenesis. (PMID: 21944719) von der Malsburg K. … van der Laan M. (Dev. Cell 2011) 2 3
  3. Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt. (PMID: 25737280) Murn J. … Shi Y. (Genes Dev. 2015) 3
  4. Proteomic analysis of the epidermal growth factor receptor (EGFR) interactome and post-translational modifications associated with receptor endocytosis in response to EGF and stress. (PMID: 24797263) Tong J. … Moran M.F. (Mol. Cell Proteomics 2014) 3
  5. Genome-wide association study identifies a novel susceptibility gene for serum TSH levels in Chinese populations. (PMID: 24852370) Zhan M. … Song H.D. (Hum. Mol. Genet. 2014) 3

Products for MINOS1 Gene

Sources for MINOS1 Gene

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