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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MINOS1 Gene

protein-coding   GIFtS: 43
GCID: GC01P019924

Mitochondrial Inner Membrane Organizing System 1

(Previous name: chromosome 1 open reading frame 151)
(Previous symbol: C1orf151)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Mitochondrial Inner Membrane Organizing System 11 2
C1orf1511 2 3
Chromosome 1 Open Reading Frame 1511
MIO102
Mitochondrial Inner Membrane Organizing System Protein 12
UPF0327 Protein C1orf1512

External Ids:    HGNC: 320681   Entrez Gene: 4405742   Ensembl: ENSG000001734367   UniProtKB: Q5TGZ03   
ORGUL members:         
NONCODE14:n409375      

Export aliases for MINOS1 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for MINOS1 Gene: 
MINOS1 (mitochondrial inner membrane organizing system 1) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with MINOS1 include intrahepatic cholangiocarcinoma, and cholangiocarcinoma. GO annotations related to this gene include molecular_function.

UniProtKB/Swiss-Prot: MOS1_HUMAN, Q5TGZ0
Function: May play a role in mitochondrial architecture (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_004610.19  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for MINOS1
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMINOS1 promoter sequence
   Search SABiosciences Chromatin IP Primers for MINOS1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MINOS1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.13   Ensembl cytogenetic band:  1p36.13   HGNC cytogenetic band: 1p36.13

MINOS1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MINOS1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P019924:  view genomic region     (about GC identifiers)

Start:
19,923,471 bp from pter      End:
19,956,315 bp from pter
Size:
32,845 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MOS1_HUMAN, Q5TGZ0 (See protein sequence)
Recommended Name: Mitochondrial inner membrane organizing system protein 1  
Size: 78 amino acids; 8808 Da
Subunit: Component of the MINOS/MitOS complex, that includes IMMT, HSPA9 and CHCHD3 and associates with
mitochondrial outer membrane proteins SAMM50, MTX1 and MTX2
Subcellular location: Mitochondrion inner membrane; Single-pass membrane protein. Note=The C-terminus is located
in the intermembrane space (By similarity), while the location of the N-terminus has not been determined yet. As
some programs predict the presence of 2 closely apposed membrane domains, it has been proposed that the protein
may cross the membrane twice and that both termini may face the intermembrane space (PubMed:22114354)
Sequence caution: Sequence=AAH09927.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: Q96G68
Alternative splicing: 2 isoforms:  Q5TGZ0-1   Q5TGZ0-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MINOS1: NX_Q5TGZ0

Explore proteomics data for MINOS1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q5TGZ0

  • MINOS1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MINOS1 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001027535.1  NP_001191011.1  NP_001191012.1  

    ENSEMBL proteins: 
     ENSP00000325562  

    Human Recombinant Protein Products for MINOS1: 
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    Cloud-Clone Corp. Proteins for MINOS1 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IBA--
    GO:0005743mitochondrial inner membrane IEA--
    GO:0016021integral to membrane IEA--

    MINOS1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR007512 DUF543

    Graphical View of Domain Structure for InterPro Entry Q5TGZ0

    ProtoNet protein and cluster: Q5TGZ0

    UniProtKB/Swiss-Prot: MOS1_HUMAN, Q5TGZ0
    Similarity: Belongs to the mitochondrial organizing structure protein type 1 family


    MINOS1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MOS1_HUMAN, Q5TGZ0
    Function: May play a role in mitochondrial architecture (By similarity)

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
         
    MINOS1 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for MINOS1 
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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MINOS1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/39 Interacting proteins for MINOS1 (Q5TGZ03 ENSP000003255624) via UniProtKB, MINT, STRING, and/or I2D (see all 39)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ACOT9Q9Y3053, ENSP000003686054I2D: score=1 STRING: ENSP00000368605
    ACSL4O604883, ENSP000003397874I2D: score=1 STRING: ENSP00000339787
    C1QBPQ070213, ENSP000002256984I2D: score=1 STRING: ENSP00000225698
    DNAJC11Q9NVH13, ENSP000003668004I2D: score=1 STRING: ENSP00000366800
    GDI1P311503, ENSP000003940714I2D: score=1 STRING: ENSP00000394071
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--

    MINOS1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MINOS1 (MOS1)

    Search CenterWatch for drugs/clinical trials and news about MINOS1 / MOS1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MINOS1 gene (3 alternative transcripts): 
    NM_001032363.3  NM_001204082.1  NM_001204083.1  

    Unigene Cluster for MINOS1:

    Mitochondrial inner membrane organizing system 1
    Hs.466662  [show with all ESTs]
    Unigene Representative Sequence: NM_001204083
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000486890 ENST00000322753(uc001bch.2 uc001bci.2 uc021oht.1 uc021ohu.1 uc021ohv.1)
    ENST00000498067 ENST00000462646 ENST00000467029 ENST00000481464 ENST00000498642
    ENST00000479642 ENST00000485362
    miRNA
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    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate MINOS1
    SwitchGear 3'UTR luciferase reporter plasmidMINOS1 3' UTR sequence
    Inhib. RNA
    Products:
         
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MINOS1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MINOS1

    Additional mRNA sequence: 

    AK094318.1 AK096240.1 BC070388.1 NR_033757.2 NR_033758.2 

    24/29 DOTS entries (see all 29):

    DT.316188  DT.91704380  DT.121421100  DT.100817073  DT.212981  DT.100767844  DT.92434766  DT.97759687 
    DT.100059410  DT.99997086  DT.121421203  DT.91693037  DT.121421145  DT.121421075  DT.121421161  DT.91990568 
    DT.92434762  DT.95278272  DT.99973574  DT.121420957  DT.121420988  DT.121421050  DT.203724  DT.97836009 

    24/683 AceView cDNA sequences (see all 683):

    BF724246 AI160894 CA431732 BU624114 CA436821 AI927268 BM923803 BM738394 
    CA423593 AI005016 AI087950 AA962155 BM737839 BG057665 T31861 AI888629 
    AI814216 BM974841 CK821425 BQ224585 BM504924 AA713647 AI475505 CA435607 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MINOS1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTATTCCTC
    MINOS1 Expression
    About this image


    See MINOS1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MINOS1

    SOURCE GeneReport for Unigene cluster: Hs.466662
        SABiosciences Custom PCR Arrays for MINOS1
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MINOS1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for MINOS1 gene from 4/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Minos11 , 5 mitochondrial inner membrane organizing system 11, 5 89.64(n)1
    94.59(a)1
      4 (70.57 cM)5
    4337711  NM_001163006.21  NP_001156478.11 
     1391018145 
    chicken
    (Gallus gallus)
    Aves MINOS11 mitochondrial inner membrane organizing system 1 81.74(n)
    83.56(a)
      419474  XM_417631.3  XP_417631.2 
    zebrafish
    (Danio rerio)
    Actinopterygii minos11 mitochondrial inner membrane organizing system 1 65.32(n)
    66.22(a)
      751699  NM_001142955.1  NP_001136427.1 
    worm
    (Caenorhabditis elegans)
    Secernentea F54A3.56
    Mitochondrial inner membrane organizing system pro...
    40(a)
    1 ↔ 1
    II(2224357-2225710)


    ENSEMBL Gene Tree for MINOS1 (if available)
    TreeFam Gene Tree for MINOS1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MINOS1 gene
    1 SIMAP similar gene for MINOS1 using alignment to 1 protein entry:     MOS1_HUMAN:
    NBL1

    MINOS1 for paralogs           About GeneDecksing


    5 Pseudogenes.org Pseudogenes for MINOS1
    PGOHUM00000239778 PGOHUM00000256720 PGOHUM00000237148 PGOHUM00000257059 PGOHUM00000257092


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    2 SNPs in MINOS1 are shown    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs605804721,2
    ----19935517(+) TTTTT-/TGAGAT 5 -- int10--------
    rs3718032151,2
    ----19936861(+) CCCGG-/CTTT  
      TTTTTT
    TTTTT
    5 -- int10--------

    HapMap Linkage Disequilibrium report for MINOS1 (19923471 - 19956315 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for MINOS1: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing MINOS1
    DNA2.0 Custom Variant and Variant Library Synthesis for MINOS1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    3 diseases for MINOS1:    About MalaCards
    intrahepatic cholangiocarcinoma    cholangiocarcinoma    gastric cancer


    MINOS1 for disorders           About GeneDecksing


    Export disorders for MINOS1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MINOS1 gene, integrated from 9 sources (see all 11):
    (articles sorted by number of sources associating them with MINOS1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. MINOS1 is a conserved component of mitofilin complexe s and required for mitochondrial function and cristae organization. (PubMed id 22114354)1, 2 Alkhaja A.K....Deckers M. (2012)
    2. Dual role of mitofilin in mitochondrial membrane orga nization and protein biogenesis. (PubMed id 21944719)1, 3 von der Malsburg K....van der Laan M. (2011)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    6. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
    7. Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (PubMed id 16712791)1 Wang A.G....Kim N.S. (2006)
    8. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    9. Transcriptome analysis of human gastric cancer. (PubMed id 16341674)1 Oh J.H....Kim N.S. (2005)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 440574 HGNC: 32068 AceView: NBL1 Ensembl:ENSG00000173436 euGenes: HUgn440574
    ECgene: MINOS1 H-InvDB: MINOS1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MINOS1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MINOS1 gene:
    Search GeneIP for patents involving MINOS1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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