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Aliases for MINOS1 Gene

Aliases for MINOS1 Gene

  • Mitochondrial Inner Membrane Organizing System 1 2 3 5
  • Mitochondrial Inner Membrane Organizing System Protein 1 3 4
  • C1orf151 3 4
  • MIC10 3 4
  • Chromosome 1 Open Reading Frame 151 2
  • MICOS Complex Subunit MIC10 3
  • UPF0327 Protein C1orf151 3
  • RP5-1056L3.2 3
  • MIO10 3

External Ids for MINOS1 Gene

Previous HGNC Symbols for MINOS1 Gene

  • C1orf151

Previous GeneCards Identifiers for MINOS1 Gene

  • GC01P019924

Summaries for MINOS1 Gene

GeneCards Summary for MINOS1 Gene

MINOS1 (Mitochondrial Inner Membrane Organizing System 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for MINOS1 Gene

  • Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.

Additional gene information for MINOS1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MINOS1 Gene

Genomics for MINOS1 Gene

Regulatory Elements for MINOS1 Gene

Enhancers for MINOS1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H019619 1.4 Ensembl ENCODE dbSUPER 13.2 +23.2 23188 0 ELF3 FOXA2 ATF1 MLX ARID4B DMAP1 RARA CREM MIXL1 THAP11 LOC105378614 MINOS1 RNU4-28P RPS14P3 NBL1
GH01H019383 1.5 Ensembl ENCODE dbSUPER 11.9 -211.1 -211141 4 FOXA2 ARID4B DMAP1 SLC30A9 ZNF143 SP5 KAT8 NFIL3 RCOR2 HNF4A CAPZB AKR7A2 LOC105378614 MINOS1 RNU4-28P NBL1 HTR6 PQLC2 GC01P019361 RN7SL277P
GH01H019389 1.4 Ensembl ENCODE dbSUPER 11.9 -205.0 -205020 4 HDAC1 ATF1 RB1 TBL1XR1 ZNF2 RAD21 ZNF766 GATA2 ZNF143 RCOR1 LOC105378614 MINOS1 CAPZB RNU4-28P PQLC2 AKR7A2 AKR7A3 RN7SL277P GC01P019361
GH01H019622 0.9 ENCODE dbSUPER 13.1 +26.4 26446 1 GATAD2A ARID4B HMG20A ATF2 NFIL3 JUND ZNF629 CEBPA CREB1 HNF4A MINOS1 LOC105378614 RNU4-28P CDA AKR7A2 NBL1 RPS14P3
GH01H019388 0.4 dbSUPER 11.9 -208.1 -208081 1 RAD21 LOC105378614 MINOS1 RNU4-28P CAPZB PQLC2 GC01P019361 RN7SL277P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MINOS1 on UCSC Golden Path with GeneCards custom track

Promoters for MINOS1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000002480 323 1801 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1

Genomic Location for MINOS1 Gene

Chromosome:
1
Start:
19,596,977 bp from pter
End:
19,629,821 bp from pter
Size:
32,845 bases
Orientation:
Plus strand

Genomic View for MINOS1 Gene

Genes around MINOS1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MINOS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MINOS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MINOS1 Gene

Proteins for MINOS1 Gene

  • Protein details for MINOS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5TGZ0-MIC10_HUMAN
    Recommended name:
    MICOS complex subunit MIC10
    Protein Accession:
    Q5TGZ0
    Secondary Accessions:
    • Q96G68

    Protein attributes for MINOS1 Gene

    Size:
    78 amino acids
    Molecular mass:
    8808 Da
    Quaternary structure:
    • Component of the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MINOS1/MIC10, CHCHD3/MIC19, CHCHD6/MIC25, APOOL/MIC27, IMMT/MIC60, APOO/MIC23/MIC26 and QIL1/MIC13. This complex was also known under the names MINOS or MitOS complex. The MICOS complex associates with mitochondrial outer membrane proteins SAMM50, MTX1, MTX2 and DNAJC11, mitochondrial inner membrane protein TMEM11 and with HSPA9. Interacts with IMMT/MIC60 and QIL1/MIC13. Interacts with APOO/MIC23/MIC26 and APOOL/MIC27.
    SequenceCaution:
    • Sequence=AAH09927.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for MINOS1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MINOS1 Gene

Post-translational modifications for MINOS1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MINOS1 Gene

No data available for DME Specific Peptides for MINOS1 Gene

Domains & Families for MINOS1 Gene

Gene Families for MINOS1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for MINOS1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MINOS1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5TGZ0

UniProtKB/Swiss-Prot:

MIC10_HUMAN :
  • Belongs to the MICOS complex subunit Mic10 family.
Family:
  • Belongs to the MICOS complex subunit Mic10 family.
genes like me logo Genes that share domains with MINOS1: view

Function for MINOS1 Gene

Molecular function for MINOS1 Gene

UniProtKB/Swiss-Prot Function:
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.

Phenotypes From GWAS Catalog for MINOS1 Gene

Gene Ontology (GO) - Molecular Function for MINOS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 25764979
genes like me logo Genes that share ontologies with MINOS1: view
genes like me logo Genes that share phenotypes with MINOS1: view

Animal Model Products

CRISPR Products

miRNA for MINOS1 Gene

miRTarBase miRNAs that target MINOS1

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for MINOS1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MINOS1 Gene

Localization for MINOS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MINOS1 Gene

Mitochondrion inner membrane; Single-pass membrane protein. Note=The C-terminus is located in the intermembrane space (By similarity), while the location of the N-terminus has not been determined yet. As some programs predict the presence of 2 closely apposed membrane domains, it has been proposed that the protein may cross the membrane twice and that both termini may face the intermembrane space (PubMed:22114354). {ECO:0000250, ECO:0000269 PubMed:22114354}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MINOS1 gene
Compartment Confidence
mitochondrion 5
cytosol 2
extracellular 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MINOS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA,IEA 20833797
GO:0005743 mitochondrial inner membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0061617 MICOS complex IEA --
genes like me logo Genes that share ontologies with MINOS1: view

Pathways & Interactions for MINOS1 Gene

SuperPathways for MINOS1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MINOS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with MINOS1: view

No data available for Pathways by source and SIGNOR curated interactions for MINOS1 Gene

Drugs & Compounds for MINOS1 Gene

No Compound Related Data Available

Transcripts for MINOS1 Gene

Unigene Clusters for MINOS1 Gene

Mitochondrial inner membrane organizing system 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for MINOS1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MINOS1 Gene

No ASD Table

Relevant External Links for MINOS1 Gene

GeneLoc Exon Structure for
MINOS1
ECgene alternative splicing isoforms for
MINOS1

Expression for MINOS1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MINOS1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MINOS1 Gene

This gene is overexpressed in Bone (16.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MINOS1 Gene



Protein tissue co-expression partners for MINOS1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MINOS1 Gene:

MINOS1

SOURCE GeneReport for Unigene cluster for MINOS1 Gene:

Hs.466662

Evidence on tissue expression from TISSUES for MINOS1 Gene

  • Nervous system(3.9)
genes like me logo Genes that share expression patterns with MINOS1: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MINOS1 Gene

Orthologs for MINOS1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MINOS1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MINOS1 33 34
  • 99.05 (n)
dog
(Canis familiaris)
Mammalia MINOS1 33 34
  • 94.67 (n)
oppossum
(Monodelphis domestica)
Mammalia MINOS1 34
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MINOS1 33
  • 89.78 (n)
mouse
(Mus musculus)
Mammalia Minos1 33 16 34
  • 88.89 (n)
rat
(Rattus norvegicus)
Mammalia LOC100361944 33
  • 88 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MINOS1 34
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves MINOS1 33 34
  • 81.08 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100135143 33
  • 72.97 (n)
zebrafish
(Danio rerio)
Actinopterygii minos1 33 34
  • 66.67 (n)
worm
(Caenorhabditis elegans)
Secernentea F54A3.5 34
  • 40 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MIC10 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5565 34
  • 27 (a)
OneToOne
Species where no ortholog for MINOS1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MINOS1 Gene

ENSEMBL:
Gene Tree for MINOS1 (if available)
TreeFam:
Gene Tree for MINOS1 (if available)

Paralogs for MINOS1 Gene

(1) SIMAP similar genes for MINOS1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MINOS1: view

No data available for Paralogs for MINOS1 Gene

Variants for MINOS1 Gene

Sequence variations from dbSNP and Humsavar for MINOS1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000068305 -- 19,595,625(+) AAACA(A/G)TCCTC intron-variant, upstream-variant-2KB
rs1000116952 -- 19,596,053(+) AATCA(C/T)CTCTA intron-variant, upstream-variant-2KB
rs1000170163 -- 19,603,599(+) GGCTG(A/T)GTCCC intron-variant
rs1000280616 -- 19,597,670(+) AATTG(C/T)GCTGG intron-variant, upstream-variant-2KB
rs1000492563 -- 19,621,320(+) TTGTT(A/G)CTACC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MINOS1 Gene

Variant ID Type Subtype PubMed ID
esv1007512 OTHER inversion 20482838
esv3553344 CNV deletion 23714750
nsv1011246 CNV gain 25217958
nsv1076211 CNV deletion 25765185
nsv1144359 CNV deletion 24896259
nsv159533 CNV deletion 16902084
nsv508991 CNV insertion 20534489
nsv945809 CNV duplication 23825009

Variation tolerance for MINOS1 Gene

Residual Variation Intolerance Score: 54.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.03; 0.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MINOS1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MINOS1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MINOS1 Gene

Disorders for MINOS1 Gene

Relevant External Links for MINOS1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MINOS1

No disorders were found for MINOS1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MINOS1 Gene

Publications for MINOS1 Gene

  1. The non-glycosylated isoform of MIC26 is a constituent of the mammalian MICOS complex and promotes formation of crista junctions. (PMID: 25764979) Koob S … Reichert AS (Biochimica et biophysica acta 2015) 3 4 60
  2. MINOS1 is a conserved component of mitofilin complexes and required for mitochondrial function and cristae organization. (PMID: 22114354) Alkhaja AK … Deckers M (Molecular biology of the cell 2012) 3 4 60
  3. Dual role of mitofilin in mitochondrial membrane organization and protein biogenesis. (PMID: 21944719) von der Malsburg K … van der Laan M (Developmental cell 2011) 2 3 60
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 60
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60

Products for MINOS1 Gene

Sources for MINOS1 Gene

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