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Aliases for MINK1 Gene

Aliases for MINK1 Gene

  • Misshapen Like Kinase 1 2 3
  • Misshapen/NIK-Related Kinase 2 3 4
  • Mitogen-Activated Protein Kinase Kinase Kinase Kinase 6 3 4
  • MAPK/ERK Kinase Kinase Kinase 6 3 4
  • Misshapen-Like Kinase 1 2 5
  • MEK Kinase Kinase 6 3 4
  • EC 2.7.11.1 4 63
  • MEKKK 6 3 4
  • MAP4K6 3 4
  • MinK 3 4
  • YSK2 3 4
  • B55 3 4
  • ZC3 3 4
  • Misshapen-Like Kinase 1 (Zebrafish) 2
  • GCK Family Kinase MINK 3
  • GCK Family Kinase MiNK 4
  • EC 2.7.11 63

External Ids for MINK1 Gene

Previous GeneCards Identifiers for MINK1 Gene

  • GC17P004684
  • GC17P004736

Summaries for MINK1 Gene

Entrez Gene Summary for MINK1 Gene

  • This gene encodes a serine/threonine kinase belonging to the germinal center kinase (GCK) family. The protein is structurally similar to the kinases that are related to NIK and may belong to a distinct subfamily of NIK-related kinases within the GCK family. Studies of the mouse homolog indicate an up-regulation of expression in the course of postnatal mouse cerebral development and activation of the cJun N-terminal kinase (JNK) and the p38 pathways. [provided by RefSeq, Mar 2016]

GeneCards Summary for MINK1 Gene

MINK1 (Misshapen Like Kinase 1) is a Protein Coding gene. Among its related pathways are Cellular Senescence and Insulin Signaling. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAP4K3.

UniProtKB/Swiss-Prot for MINK1 Gene

  • Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking. Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons. Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates: TANC1 upon stimulation by RAP2A, MBP and SMAD1. Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1.

  • Isoform 4 can activate the JNK pathway. Involved in the regulation of actin cytoskeleton reorganization, cell-matrix adhesion, cell-cell adhesion and cell migration.

Gene Wiki entry for MINK1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MINK1 Gene

Genomics for MINK1 Gene

Regulatory Elements for MINK1 Gene

Enhancers for MINK1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MINK1 on UCSC Golden Path with GeneCards custom track

Promoters for MINK1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MINK1 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the MINK1 gene promoter:

Genomic Location for MINK1 Gene

Chromosome:
17
Start:
4,833,340 bp from pter
End:
4,898,061 bp from pter
Size:
64,722 bases
Orientation:
Plus strand

Genomic View for MINK1 Gene

Genes around MINK1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MINK1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MINK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MINK1 Gene

Proteins for MINK1 Gene

  • Protein details for MINK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N4C8-MINK1_HUMAN
    Recommended name:
    Misshapen-like kinase 1
    Protein Accession:
    Q8N4C8
    Secondary Accessions:
    • D3DTK3
    • D3DTK4
    • Q5U8Z0
    • Q9P1X1
    • Q9P2R8

    Protein attributes for MINK1 Gene

    Size:
    1332 amino acids
    Molecular mass:
    149822 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interacts with TANC1 (By similarity). Interacts with RAP2A. Isoform 4 interacts with NCK1.

    Alternative splice isoforms for MINK1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MINK1 Gene

Proteomics data for MINK1 Gene at MOPED

Post-translational modifications for MINK1 Gene

Domains & Families for MINK1 Gene

Gene Families for MINK1 Gene

Suggested Antigen Peptide Sequences for MINK1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N4C8

UniProtKB/Swiss-Prot:

MINK1_HUMAN :
  • Contains 1 CNH domain.
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
Domain:
  • Contains 1 CNH domain.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
genes like me logo Genes that share domains with MINK1: view

Function for MINK1 Gene

Molecular function for MINK1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot Function:
Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking. Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons. Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates: TANC1 upon stimulation by RAP2A, MBP and SMAD1. Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1.
UniProtKB/Swiss-Prot Function:
Isoform 4 can activate the JNK pathway. Involved in the regulation of actin cytoskeleton reorganization, cell-matrix adhesion, cell-cell adhesion and cell migration.
UniProtKB/Swiss-Prot Induction:
Activated after Ras induction via a mechanism involving reactive oxygen species.

Enzyme Numbers (IUBMB) for MINK1 Gene

genes like me logo Genes that share phenotypes with MINK1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for MINK1

miRNA for MINK1 Gene

miRTarBase miRNAs that target MINK1

In Situ Assay Products

Flow Cytometry Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MINK1 Gene

Localization for MINK1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MINK1 Gene

Cytoplasm. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell projection, axon. Cell projection, dendrite.
Isoform 4: Golgi apparatus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MINK1 Gene COMPARTMENTS Subcellular localization image for MINK1 gene
Compartment Confidence
cytosol 5
extracellular 5
golgi apparatus 5
nucleus 4
plasma membrane 3
cytoskeleton 1
endosome 1

Gene Ontology (GO) - Cellular Components for MINK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0030425 dendrite IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with MINK1: view

Pathways & Interactions for MINK1 Gene

genes like me logo Genes that share pathways with MINK1: view

Pathways by source for MINK1 Gene

SIGNOR curated interactions for MINK1 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for MINK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001952 regulation of cell-matrix adhesion IMP 15469942
GO:0006468 protein phosphorylation IEA,ISS --
GO:0006950 response to stress ISS --
GO:0007268 synaptic transmission ISS --
GO:0007275 multicellular organism development ISS --
genes like me logo Genes that share ontologies with MINK1: view

Drugs & Compounds for MINK1 Gene

(2) Drugs for MINK1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Magnesium Nutra 0

(1) Additional Compounds for MINK1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with MINK1: view

Transcripts for MINK1 Gene

Unigene Clusters for MINK1 Gene

Misshapen-like kinase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MINK1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b · 18c ^ 19a · 19b ^ 20a ·
SP1:
SP2:
SP3: -
SP4:
SP5:
SP6: - - - - - - - - - - - - - - - -
SP7:
SP8: - -
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

ExUns: 20b · 20c ^ 21 ^ 22a · 22b ^ 23 ^ 24a · 24b ^ 25 ^ 26a · 26b · 26c · 26d ^ 27 ^ 28a · 28b ^ 29a · 29b · 29c
SP1: -
SP2:
SP3: -
SP4: -
SP5:
SP6: - -
SP7:
SP8:
SP9: - -
SP10: -
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for MINK1 Gene

GeneLoc Exon Structure for
MINK1
ECgene alternative splicing isoforms for
MINK1

Expression for MINK1 Gene

mRNA expression in normal human tissues for MINK1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MINK1 Gene

This gene is overexpressed in Brain (29.9), Heart (10.6), and Frontal cortex (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MINK1 Gene



SOURCE GeneReport for Unigene cluster for MINK1 Gene Hs.443417

mRNA Expression by UniProt/SwissProt for MINK1 Gene

Q8N4C8-MINK1_HUMAN
Tissue specificity: Expressed in the brain, isoform 2 is more abundant than isoform 1. Isoform 3 is ubiquitously expressed. Isoform 1 is most abundant in the skeletal muscle. Isoform 4 is ubiquitously expressed with relative high levels in brain, skeletal muscle, pancreas and testis.
genes like me logo Genes that share expression patterns with MINK1: view

Protein tissue co-expression partners for MINK1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for MINK1 Gene

Orthologs for MINK1 Gene

This gene was present in the common ancestor of animals.

Orthologs for MINK1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MINK1 35
  • 91.95 (n)
  • 97.48 (a)
MINK1 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MINK1 35
  • 89.81 (n)
  • 95.34 (a)
MINK 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mink1 35
  • 91.01 (n)
  • 97.45 (a)
Mink1 16
Mink1 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MINK1 35
  • 99.7 (n)
  • 99.77 (a)
MINK1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mink1 35
  • 90.46 (n)
  • 97.07 (a)
oppossum
(Monodelphis domestica)
Mammalia MINK1 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 48 (a)
ManyToMany
chicken
(Gallus gallus)
Aves NRK 36
  • 58 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia MINK1 36
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mink1 35
  • 77.1 (n)
  • 86.23 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.538 35
zebrafish
(Danio rerio)
Actinopterygii mink1 36
  • 76 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta msn 36
  • 43 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea mig-15 36
  • 51 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3520 36
  • 46 (a)
OneToMany
Species with no ortholog for MINK1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MINK1 Gene

ENSEMBL:
Gene Tree for MINK1 (if available)
TreeFam:
Gene Tree for MINK1 (if available)

Paralogs for MINK1 Gene

Paralogs for MINK1 Gene

genes like me logo Genes that share paralogs with MINK1: view

Variants for MINK1 Gene

Sequence variations from dbSNP and Humsavar for MINK1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs56131206 - 4,890,709(+) ATCCC(A/G)CTGAC reference, missense
VAR_040800 -
rs11556634 - 4,892,979(+) TCCAG(A/C/G/T)CTCCT reference, missense
rs11556635 - 4,892,991(+) CAAAC(C/T)GGACA reference, missense
rs2302319 - 4,894,010(-) GCTGA(C/T)GCTGT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for MINK1 Gene

Variant ID Type Subtype PubMed ID
nsv833346 CNV Loss 17160897
nsv833347 CNV Loss 17160897
esv2537517 CNV Insertion 19546169
esv1520671 CNV Insertion 17803354
nsv833349 CNV Loss 17160897
esv2715558 CNV Deletion 23290073
nsv1953 CNV Insertion 18451855
nsv509647 CNV Insertion 20534489
nsv907619 CNV Loss 21882294
nsv907620 CNV Loss 21882294
esv1005973 CNV Insertion 20482838
esv2715559 CNV Deletion 23290073
nsv833350 CNV Loss 17160897

Variation tolerance for MINK1 Gene

Residual Variation Intolerance Score: 4.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.48; 85.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MINK1 Gene

HapMap Linkage Disequilibrium report
MINK1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MINK1 Gene

Disorders for MINK1 Gene

Relevant External Links for MINK1

Genetic Association Database (GAD)
MINK1
Human Genome Epidemiology (HuGE) Navigator
MINK1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MINK1

No disorders were found for MINK1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MINK1 Gene

Publications for MINK1 Gene

  1. Molecular cloning of MINK, a novel member of mammalian GCK family kinases, which is up-regulated during postnatal mouse cerebral development. (PMID: 10708748) Dan I. … Kusumi A. (FEBS Lett. 2000) 2 3 4 67
  2. Computational and experimental studies on human misshapen/NIK-related kinase MINK-1. (PMID: 15032605) Qu K. … Xu D. (Curr. Med. Chem. 2004) 3 23
  3. Identification and functional characterization of a novel human misshapen/Nck interacting kinase-related kinase, hMINK beta. (PMID: 15469942) Hu Y. … Xu X. (J. Biol. Chem. 2004) 3 23
  4. Overlapping of MINK and CHRNE gene loci in the course of mammalian evolution. (PMID: 12087176) Dan I. … Kusumi A. (Nucleic Acids Res. 2002) 2 3
  5. The role of Misshapen NCK-related kinase (MINK), a novel Ste20 family kinase, in the IRES-mediated protein translation of human enterovirus 71. (PMID: 25747578) Leong S.Y. … Chu J.J. (PLoS Pathog. 2015) 3

Products for MINK1 Gene

Sources for MINK1 Gene

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