Aliases for MINK1 Gene
Aliases for MINK1 Gene
External Ids for MINK1 Gene
- HGNC: 17565
- Entrez Gene: 50488
- Ensembl: ENSG00000141503
- OMIM: 609426
- UniProtKB: Q8N4C8
Previous GeneCards Identifiers for MINK1 Gene
- GC17P004684
- GC17P004736
Summaries for MINK1 Gene
-
This gene encodes a serine/threonine kinase belonging to the germinal center kinase (GCK) family. The protein is structurally similar to the kinases that are related to NIK and may belong to a distinct subfamily of NIK-related kinases within the GCK family. Studies of the mouse homolog indicate an up-regulation of expression in the course of postnatal mouse cerebral development and activation of the cJun N-terminal kinase (JNK) and the p38 pathways. [provided by RefSeq, Mar 2016]
GeneCards Summary for MINK1 Gene
MINK1 (Misshapen Like Kinase 1) is a Protein Coding gene. Diseases associated with MINK1 include Long Qt Syndrome and Long Qt Syndrome 1. Among its related pathways are Angiopoietin Like Protein 8 Regulatory Pathway and Cellular Senescence (REACTOME). Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is TNIK.
UniProtKB/Swiss-Prot for MINK1 Gene
-
Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking. Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons. Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates: TANC1 upon stimulation by RAP2A, MBP and SMAD1. Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1.
-
Isoform 4 can activate the JNK pathway. Involved in the regulation of actin cytoskeleton reorganization, cell-matrix adhesion, cell-cell adhesion and cell migration.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MINK1 Gene
Genomics for MINK1 Gene
GeneHancer (GH) Regulatory Elements for MINK1 Gene
Promoters and enhancers for MINK1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around MINK1 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for MINK1 Gene
Genomic Locations for MINK1 Gene
- chr17:4,833,340-4,898,061
- (GRCh38/hg38)
- Size:
- 64,722 bases
- Orientation:
- Plus strand
- chr17:4,736,635-4,801,356
- (GRCh37/hg19)
Genomic View for MINK1 Gene
Genes around MINK1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17p13.2 by Ensembl
- 17p13.2 by Entrez Gene
- 17p13.2 by HGNC
MINK1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MINK1 Gene
Proteins for MINK1 Gene
-
Protein details for MINK1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8N4C8-MINK1_HUMAN
- Recommended name:
- Misshapen-like kinase 1
- Protein Accession:
- Q8N4C8
- D3DTK3
- D3DTK4
- Q5U8Z0
- Q9P1X1
- Q9P2R8
Protein attributes for MINK1 Gene
- Size:
- 1332 amino acids
- Molecular mass:
- 149822 Da
- Cofactor:
- Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Quaternary structure:
-
- Interacts with TANC1 (By similarity). Interacts with RAP2A. Isoform 4 interacts with NCK1.
Protein Expression for MINK1 Gene
Selected DME Specific Peptides for MINK1 Gene
- Q8N4C8:
-
- FIGTPYWMAPEV
- PFIRDQP
- EGVYVNTYGR
- VVLQWGEMP
- TGHLDGVFMHK
- VIHRDIKGQNVLLT
- SVVNVNPTN
- MEFCGAGS
- EILCAALWGVNLL
- RNDKVFF
- LRDPAGIFEL
- VGNGTYGQVYKGRHVKTGQLAAIKVMDVT
- ILHNDPEVEKKQGW
- PRLKSKKWSKKF
- ERQVRIQLKDHIDR
- GITAIEMAEGAPPLC
- RVYYLSWLR
- GLMLLDRSGQGKVY
- LNLLITISG
- ETEYEYSGSEEE
- YAWAPKPYHKFM
- WMAPEVI
- VKLVDFGVSAQL
- RRRFQQMDVLEGLN
- ATYYGAFIKK
- GTPYWMAPE
- DQLWLVMEFCG
- KAIEIRSV
- YERIKFLV
- AAIKVMDVTEDEEEEI
- PEIRKYKK
- DYSSSSEE
Post-translational modifications for MINK1 Gene
- Autophosphorylated.
Other Protein References for MINK1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for MINK1
- Novus Biologicals Antibodies for MINK1
-
Abcam antibodies for MINK1
- Invitrogen Antibodies for MINK1
- GeneTex MINK1 antibody for MINK1
Protein Products
-
OriGene Purified Proteins for MINK1
- Search Origene for MassSpec and Protein Over-expression Lysates for MINK1
- Origene Custom Protein Services for MINK1
- Search GeneTex for Proteins for MINK1
-
Abcam proteins for MINK1
Assay Products
Domains & Families for MINK1 Gene
Gene Families for MINK1 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for MINK1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for MINK1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q8N4C8UniProtKB/Swiss-Prot:
MINK1_HUMAN :- Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
- Family:
-
- Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
Function for MINK1 Gene
Molecular function for MINK1 Gene
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + a protein = ADP + a phosphoprotein.
- UniProtKB/Swiss-Prot Function:
- Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking. Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons. Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates: TANC1 upon stimulation by RAP2A, MBP and SMAD1. Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1.
- UniProtKB/Swiss-Prot Function:
- Isoform 4 can activate the JNK pathway. Involved in the regulation of actin cytoskeleton reorganization, cell-matrix adhesion, cell-cell adhesion and cell migration.
- UniProtKB/Swiss-Prot Induction:
- Activated after Ras induction via a mechanism involving reactive oxygen species.
Enzyme Numbers (IUBMB) for MINK1 Gene
Phenotypes From GWAS Catalog for MINK1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004672 | protein kinase activity | IEA,TAS | 10708748 |
| GO:0004674 | protein serine/threonine kinase activity | IDA,IEA | 18930710 |
| GO:0005515 | protein binding | IPI | 15469942 |
| GO:0005524 | ATP binding | IEA,ISS | -- |
| GO:0008349 | MAP kinase kinase kinase kinase activity | IBA | -- |
Phenotypes for MINK1 Gene
- GenomeRNAi human phenotypes for MINK1:
-
- Increased vaccinia virus (VACV) infection
- Decreased viability ratio
- Increased transferrin (TF) endocytosis
- Increased shRNA abundance (Z-score > 2)
- Decreased shRNA abundance (Z-score < -2)
- Decreased substrate adherent cell growth
- Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance
- Decreased cell migration
- Decreased homologous recombination repair frequency
- Increased cell death HMECs cells
- Decreased viability
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for MINK1
-
-
ViGene Biosciences lentiviral particle packaged cDNA for MINK1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for MINK1 gene
- Search ViGene Biosciences for MINK1
CRISPR Products
-
OriGene CRISPR knockouts for MINK1
- genomics-online: gRNA clones - Search results for available MINK1 gene related products
- Applied Biological Materials CRISPR for MINK1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for MINK1
- GenScript: Design CRISPR guide RNA sequences for MINK1
miRNA for MINK1 Gene
- miRTarBase miRNAs that target MINK1
-
- hsa-mir-1301-3p (MIRT036060)
- hsa-mir-760 (MIRT036771)
- hsa-mir-744-5p (MIRT037477)
- hsa-mir-18a-3p (MIRT040973)
- hsa-mir-186-5p (MIRT045281)
- hsa-mir-222-3p (MIRT046617)
- hsa-mir-92a-3p (MIRT049099)
- hsa-mir-15a-5p (MIRT077781)
- hsa-mir-16-5p (MIRT077782)
- hsa-mir-15b-5p (MIRT077784)
- hsa-mir-195-5p (MIRT077785)
- hsa-mir-17-5p (MIRT077830)
- hsa-mir-20a-5p (MIRT077831)
- hsa-mir-93-5p (MIRT077832)
- hsa-mir-106a-5p (MIRT077833)
- hsa-mir-106b-5p (MIRT077835)
- hsa-mir-302a-3p (MIRT077836)
- hsa-mir-302b-3p (MIRT077837)
- hsa-mir-302c-3p (MIRT077838)
- hsa-mir-302d-3p (MIRT077839)
- hsa-mir-372-3p (MIRT077840)
- hsa-mir-373-3p (MIRT077841)
- hsa-mir-20b-5p (MIRT077842)
- hsa-mir-520e (MIRT077844)
- hsa-mir-520f-3p (MIRT077845)
- hsa-mir-520a-3p (MIRT077847)
- hsa-mir-526b-3p (MIRT077848)
- hsa-mir-520b (MIRT077850)
- hsa-mir-520c-3p (MIRT077851)
- hsa-mir-519d-3p (MIRT077852)
- hsa-mir-520d-3p (MIRT077853)
- hsa-mir-302e (MIRT077857)
- hsa-mir-3646 (MIRT077859)
- hsa-mir-3662 (MIRT077860)
- hsa-mir-15b-3p (MIRT146636)
- hsa-mir-625-5p (MIRT146648)
- hsa-mir-1275 (MIRT146654)
- hsa-mir-3179 (MIRT146657)
- hsa-mir-3180-3p (MIRT146658)
- hsa-mir-3196 (MIRT146659)
- hsa-mir-3202 (MIRT146661)
- hsa-mir-3180 (MIRT146673)
- hsa-mir-4665-5p (MIRT146684)
- hsa-mir-4747-5p (MIRT146689)
- hsa-mir-5196-5p (MIRT146696)
- hsa-mir-6740-5p (MIRT146703)
- hsa-mir-6783-5p (MIRT146704)
- hsa-mir-6816-5p (MIRT146706)
- hsa-mir-7109-5p (MIRT146714)
- hsa-mir-487b-3p (MIRT440240)
- hsa-mir-6883-5p (MIRT473200)
- hsa-mir-6785-5p (MIRT473201)
- hsa-mir-4728-5p (MIRT473202)
- hsa-mir-6739-5p (MIRT473203)
- hsa-mir-149-3p (MIRT473204)
- hsa-mir-6733-5p (MIRT473205)
- hsa-mir-3153 (MIRT473206)
- hsa-mir-423-5p (MIRT473207)
- hsa-mir-3184-5p (MIRT473208)
- hsa-mir-6754-5p (MIRT473209)
- hsa-mir-4441 (MIRT473210)
- hsa-mir-4270 (MIRT473211)
- hsa-mir-4739 (MIRT473212)
- hsa-mir-4756-5p (MIRT473213)
- hsa-mir-1321 (MIRT473214)
- hsa-mir-583 (MIRT473215)
- hsa-mir-1538 (MIRT493190)
- hsa-mir-4745-3p (MIRT493191)
- hsa-mir-671-5p (MIRT493192)
- hsa-mir-1247-3p (MIRT493193)
- hsa-mir-5572 (MIRT701956)
- hsa-mir-4260 (MIRT701957)
- hsa-mir-450a-2-3p (MIRT701958)
- hsa-mir-3942-3p (MIRT701959)
- hsa-mir-6803-5p (MIRT701960)
- hsa-mir-6751-5p (MIRT701961)
- hsa-mir-5010-5p (MIRT701962)
- hsa-mir-4525 (MIRT701963)
- hsa-mir-3160-5p (MIRT701964)
- hsa-mir-3185 (MIRT701965)
- hsa-mir-4796-3p (MIRT701966)
- hsa-mir-548ah-5p (MIRT701967)
- hsa-mir-3609 (MIRT701968)
- hsa-mir-1291 (MIRT762291)
- hsa-mir-1296-3p (MIRT762370)
- hsa-mir-194-3p (MIRT763460)
- hsa-mir-214-3p (MIRT763831)
- hsa-mir-3173-5p (MIRT765228)
- hsa-mir-3619-5p (MIRT766105)
- hsa-mir-424-5p (MIRT767957)
- hsa-mir-4291 (MIRT768406)
- hsa-mir-4519 (MIRT769943)
- hsa-mir-497-5p (MIRT772808)
- hsa-mir-6752-3p (MIRT778353)
- hsa-mir-6775-3p (MIRT778729)
- hsa-mir-6799-3p (MIRT779381)
- hsa-mir-6838-5p (MIRT780092)
- hsa-mir-761 (MIRT781784)
- hsa-mir-922 (MIRT782649)
miRNA Products
- Search ViGene Biosciences for MINK1
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for MINK1
- Browse OriGene Inhibitory RNA Products For MINK1
- genomics-online: shRNA clones - Search results for available MINK1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for MINK1 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for MINK1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MINK1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for MINK1
- genomics-online: cdna clones - Search results for available MINK1 gene related products
- orf clones - Search results for available MINK1 gene related products
- Applied Biological Materials Clones for MINK1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for MINK1
-
ViGene Biosciences adenoviral particle packaged cDNA for MINK1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for MINK1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for MINK1 gene
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MINK1 Gene
Localization for MINK1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for MINK1 Gene
- Cytoplasm. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell projection, axon. Cell projection, dendrite.
- Isoform 4: Golgi apparatus.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| cytosol | 5 |
| golgi apparatus | 5 |
| nucleus | 4 |
| plasma membrane | 3 |
| cytoskeleton | 1 |
| endosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IDA,IEA | 18930710 |
| GO:0005794 | Golgi apparatus | IEA,IDA | 15469942 |
| GO:0005829 | cytosol | TAS | -- |
| GO:0005886 | plasma membrane | IEA | -- |
| GO:0014069 | postsynaptic density | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for MINK1 Gene
Pathways & Interactions for MINK1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Cellular Senescence (REACTOME) | ||
| 2 | Angiopoietin Like Protein 8 Regulatory Pathway | ||
| 3 | MAPK signaling pathway | ||
Pathways by source for MINK1 Gene
3 BioSystems pathways for MINK1 Gene
3 Reactome pathways for MINK1 Gene
Interacting Proteins for MINK1 Gene
Selected Interacting proteins:
ENSP00000347427
Q8N4C8-MINK1_HUMAN
for MINK1 Gene via
STRING
UniProtKB
IID
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000185 | activation of MAPKKK activity | IEA | -- |
| GO:0001952 | regulation of cell-matrix adhesion | IMP | 15469942 |
| GO:0006468 | protein phosphorylation | ISS,IEA | -- |
| GO:0006950 | response to stress | ISS | -- |
| GO:0007254 | JNK cascade | TAS | 10708748 |
Drugs & Compounds for MINK1 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| ADP |
|
Full agonist, Agonist | 58-64-0 |
|
Transcripts for MINK1 Gene
mRNA/cDNA for MINK1 Gene
- (14) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (57) Selected AceView cDNA sequences:
- (13) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for MINK1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for MINK1
- genomics-online: gRNA clones - Search results for available MINK1 gene related products
- Applied Biological Materials CRISPR for MINK1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for MINK1
- GenScript: Design CRISPR guide RNA sequences for MINK1
miRNA Products
- Search ViGene Biosciences for MINK1
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for MINK1
- Browse OriGene Inhibitory RNA Products For MINK1
- genomics-online: shRNA clones - Search results for available MINK1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for MINK1 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for MINK1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MINK1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for MINK1
- genomics-online: cdna clones - Search results for available MINK1 gene related products
- orf clones - Search results for available MINK1 gene related products
- Applied Biological Materials Clones for MINK1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14a | · | 14b | ^ | 15 | ^ | 16a | · | 16b | ^ | 17 | ^ | 18a | · | 18b | · | 18c | ^ | 19a | · | 19b | ^ | 20a | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP14: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP15: |
| ExUns: | 20b | · | 20c | ^ | 21 | ^ | 22a | · | 22b | ^ | 23 | ^ | 24a | · | 24b | ^ | 25 | ^ | 26a | · | 26b | · | 26c | · | 26d | ^ | 27 | ^ | 28a | · | 28b | ^ | 29a | · | 29b | · | 29c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||||||||||||||||
| SP2: | |||||||||||||||||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||||||||||
| SP6: | - | - | |||||||||||||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||||||||||||||
| SP8: | |||||||||||||||||||||||||||||||||||||
| SP9: | - | - | |||||||||||||||||||||||||||||||||||
| SP10: | - | ||||||||||||||||||||||||||||||||||||
| SP11: | |||||||||||||||||||||||||||||||||||||
| SP12: | |||||||||||||||||||||||||||||||||||||
| SP13: | |||||||||||||||||||||||||||||||||||||
| SP14: | |||||||||||||||||||||||||||||||||||||
| SP15: |
Expression for MINK1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
This gene is overexpressed in Brain (29.9), Heart (10.6), and Frontal cortex (6.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MINK1 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of MINK1 Gene:
MINK1SOURCE GeneReport for Unigene cluster for MINK1 Gene:
Hs.443417mRNA Expression by UniProt/SwissProt for MINK1 Gene:
Q8N4C8-MINK1_HUMAN
Tissue specificity:
Expressed in the brain, isoform 2 is more abundant than isoform 1. Isoform 3 is ubiquitously expressed. Isoform 1 is most abundant in the skeletal muscle. Isoform 4 is ubiquitously expressed with relative high levels in brain, skeletal muscle, pancreas and testis.
Evidence on tissue expression from TISSUES for MINK1 Gene
- Nervous system(4.7)
- Blood(4.4)
- Liver(4.2)
Primer Products
-
OriGene qPCR primer pairs for MINK1
- genomics-online: primer clones - Search results for available MINK1 gene related products
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MINK1 Gene
Orthologs for MINK1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | MINK1 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | MINK 34 |
|
OneToOne | |
| MINK1 33 |
|
||||
| oppossum (Monodelphis domestica) |
Mammalia | MINK1 34 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | MINK1 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Mink1 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Mink1 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
ManyToMany | |
| chicken (Gallus gallus) |
Aves | NRK 34 |
|
ManyToMany | |
| lizard (Anolis carolinensis) |
Reptilia | MINK1 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | mink1 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | mink1 34 |
|
OneToOne | |
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.538 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | msn 34 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | mig-15 34 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.3520 34 |
|
OneToMany |
- Species where no ortholog for MINK1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for MINK1 Gene
(40) SIMAP similar genes for MINK1 Gene using alignment to 5 proteins:
Variants for MINK1 Gene
| SNP ID | Clin | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1053751 | benign, Congenital Myasthenic Syndrome, Dominant/Recessive | 4,897,991(+) | C/T | 3_prime_UTR_variant, genic_downstream_transcript_variant | |
| rs1053754 | benign, Congenital Myasthenic Syndrome, Dominant/Recessive | 4,897,993(+) | A/C/T | 3_prime_UTR_variant, genic_downstream_transcript_variant | |
| rs113366718 | uncertain-significance, Congenital Myasthenic Syndrome, Dominant/Recessive | 4,897,931(+) | A/C | 3_prime_UTR_variant, genic_downstream_transcript_variant | |
| rs116802199 | likely-benign, Congenital Myasthenic Syndrome, Dominant/Recessive | 4,897,806(+) | A/C | 3_prime_UTR_variant, genic_downstream_transcript_variant | |
| rs144554248 | likely-benign, Congenital Myasthenic Syndrome, Dominant/Recessive | 4,898,126(+) | G/A | downstream_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv3088n100 | CNV | gain | 25217958 |
| esv1005973 | CNV | insertion | 20482838 |
| esv1520671 | CNV | insertion | 17803354 |
| esv2537517 | CNV | insertion | 19546169 |
| esv2715558 | CNV | deletion | 23290073 |
| esv2715559 | CNV | deletion | 23290073 |
| esv3341973 | CNV | duplication | 20981092 |
| esv3440715 | CNV | insertion | 20981092 |
| esv3572365 | CNV | gain | 25503493 |
| esv3582499 | CNV | loss | 25503493 |
| esv3639796 | CNV | loss | 21293372 |
| nsv1953 | CNV | insertion | 18451855 |
| nsv474658 | CNV | novel sequence insertion | 20440878 |
| nsv480316 | CNV | novel sequence insertion | 20440878 |
| nsv480688 | CNV | novel sequence insertion | 20440878 |
| nsv480726 | CNV | novel sequence insertion | 20440878 |
| nsv480878 | CNV | novel sequence insertion | 20440878 |
| nsv509647 | CNV | insertion | 20534489 |
| nsv574273 | CNV | gain | 21841781 |
| nsv574275 | CNV | gain | 21841781 |
| nsv833346 | CNV | loss | 17160897 |
| nsv833347 | CNV | loss | 17160897 |
| nsv833349 | CNV | loss | 17160897 |
| nsv833350 | CNV | loss | 17160897 |
| nsv952112 | CNV | deletion | 24416366 |
| nsv952113 | CNV | deletion | 24416366 |
| nsv960043 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
4.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
8.48;
85.80% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for MINK1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MINK1
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MINK1 Gene
Disorders for MINK1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| long qt syndrome |
|
|
| long qt syndrome 1 |
|
|
Search MINK1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for MINK1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for MINK1 Gene
Publications for MINK1 Gene
- Identification and functional characterization of a novel human misshapen/Nck interacting kinase-related kinase, hMINK beta. (PMID: 15469942) Hu Y … Xu X (The Journal of biological chemistry 2004) 3 4 22 58
- Molecular cloning of MINK, a novel member of mammalian GCK family kinases, which is up-regulated during postnatal mouse cerebral development. (PMID: 10708748) Dan I … Kusumi A (FEBS letters 2000) 2 3 4 58
- Smad inhibition by the Ste20 kinase Misshapen. (PMID: 21690388) Kaneko S … Xu L (Proceedings of the National Academy of Sciences of the United States of America 2011) 3 4 58
- MINK is a Rap2 effector for phosphorylation of the postsynaptic scaffold protein TANC1. (PMID: 18930710) Nonaka H … Kariya KI (Biochemical and biophysical research communications 2008) 3 4 58
- Molecular genetic analysis of long QT syndrome in Norway indicating a high prevalence of heterozygous mutation carriers. (PMID: 18752142) Berge KE … Leren TP (Scandinavian journal of clinical and laboratory investigation 2008) 3 44 58
Products for MINK1 Gene
- Browse R&D Systems for Antibodies
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- Custom Antibody ServicesOriGene Antibodies for MINK1
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for MINK1
- Search Origene for MassSpec and Protein Over-expression Lysates for MINK1
- Origene Custom Protein Services for MINK1
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MINK1
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- OriGene qPCR primer pairs for MINK1
- OriGene CRISPR knockouts for MINK1
- OriGene ORF clones in human for MINK1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For MINK1
- GenScript: Next-day shipping of latest version cDNA ORF clones for MINK1 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for MINK1
- GenScript Custom Assay Services for MINK1
- GenScript Custom overexpressing Cell Line Services for MINK1
- GenScript: Design CRISPR guide RNA sequences for MINK1
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for MINK1
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse Sino Biological ELISA Kits
- Browse Sino Biological ELISA Pair Sets
- Browse Sino Biological CRO Services
- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for MINK1
- Novus Biologicals proteins and lysates for MINK1
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for MINK1
- Abcam proteins for MINK1
- Find your target
- Browse Primary Antibodies
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- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Browse Antibodies at Cloud-Clone Corp.
- Browse Proteins at Cloud-Clone Corp.
- Browse Assay Kits at Cloud-Clone Corp.
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Invitrogen Antibodies for MINK1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Cyagen custom Knockout/knockin (KOKI) mouse models for MINK1
- VectorBuilder custom plasmid, inducible vectors for MINK1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MINK1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for MINK1
- antibodies-online: Search results for 49 available MINK1 Antibodies ranked by validation data
- Compare Top MINK1 Antibodies
- antibodies-online: Search results for 4 available MINK1 Elisa Kits ranked by validation data
- Compare Top MINK1 Elisa Kits
- antibodies-online: Search results for 7 available MINK1 Proteins ranked by validation data
- Compare Top MINK1 Proteins
- GeneTex MINK1 antibody for MINK1
- Search GeneTex for Proteins for MINK1
- ViGene Biosciences adenoviral particle packaged cDNA for MINK1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for MINK1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for MINK1 gene
- Search ViGene Biosciences for MINK1
- Horizon Cell Lines for MINK1
- genomics-online: cdna clones - Search results for available MINK1 gene related products
- orf clones - Search results for available MINK1 gene related products
- genomics-online: gRNA clones - Search results for available MINK1 gene related products
- genomics-online: primer clones - Search results for available MINK1 gene related products
- genomics-online: shRNA clones - Search results for available MINK1 gene related products
Sources for MINK1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew