Aliases for MINK1 Gene
Aliases for MINK1 Gene
External Ids for MINK1 Gene
- HGNC: 17565
- Entrez Gene: 50488
- Ensembl: ENSG00000141503
- OMIM: 609426
- UniProtKB: Q8N4C8
Previous GeneCards Identifiers for MINK1 Gene
- GC17P004684
- GC17P004736
Summaries for MINK1 Gene
-
This gene encodes a serine/threonine kinase belonging to the germinal center kinase (GCK) family. The protein is structurally similar to the kinases that are related to NIK and may belong to a distinct subfamily of NIK-related kinases within the GCK family. Studies of the mouse homolog indicate an up-regulation of expression in the course of postnatal mouse cerebral development and activation of the cJun N-terminal kinase (JNK) and the p38 pathways. [provided by RefSeq, Mar 2016]
GeneCards Summary for MINK1 Gene
MINK1 (Misshapen Like Kinase 1) is a Protein Coding gene. Among its related pathways are Cellular Senescence and Angiopoietin Like Protein 8 Regulatory Pathway. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is TNIK.
UniProtKB/Swiss-Prot for MINK1 Gene
-
Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking. Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons. Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates: TANC1 upon stimulation by RAP2A, MBP and SMAD1. Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1.
-
Isoform 4 can activate the JNK pathway. Involved in the regulation of actin cytoskeleton reorganization, cell-matrix adhesion, cell-cell adhesion and cell migration.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MINK1 Gene
Genomics for MINK1 Gene
Regulatory Elements for MINK1 Gene
Enhancers for MINK1 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around MINK1 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the MINK1 gene promoter:
Regulatory Element Products
Genomic Location for MINK1 Gene
- Chromosome:
- 17
- Start:
- 4,833,340 bp from pter
- End:
- 4,898,061 bp from pter
- Size:
- 64,722 bases
- Orientation:
- Plus strand
Genomic View for MINK1 Gene
Genes around MINK1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17p13.2 by Ensembl
- 17p13.2 by Entrez Gene
- 17p13.2 by HGNC
MINK1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MINK1 Gene
Proteins for MINK1 Gene
-
Protein details for MINK1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8N4C8-MINK1_HUMAN
- Recommended name:
- Misshapen-like kinase 1
- Protein Accession:
- Q8N4C8
- D3DTK3
- D3DTK4
- Q5U8Z0
- Q9P1X1
- Q9P2R8
Protein attributes for MINK1 Gene
- Size:
- 1332 amino acids
- Molecular mass:
- 149822 Da
- Cofactor:
- Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Quaternary structure:
-
- Interacts with TANC1 (By similarity). Interacts with RAP2A. Isoform 4 interacts with NCK1.
Protein Expression for MINK1 Gene
Selected DME Specific Peptides for MINK1 Gene
- Q8N4C8:
-
- FIGTPYWMAPEV
- PFIRDQP
- EGVYVNTYGR
- VVLQWGEMP
- TGHLDGVFMHK
- VIHRDIKGQNVLLT
- SVVNVNPTN
- MEFCGAGS
- EILCAALWGVNLL
- RNDKVFF
- LRDPAGIFEL
- VGNGTYGQVYKGRHVKTGQLAAIKVMDVT
- ILHNDPEVEKKQGW
- PRLKSKKWSKKF
- ERQVRIQLKDHIDR
- GITAIEMAEGAPPLC
- RVYYLSWLR
- GLMLLDRSGQGKVY
- LNLLITISG
- ETEYEYSGSEEE
- YAWAPKPYHKFM
- WMAPEVI
- VKLVDFGVSAQL
- RRRFQQMDVLEGLN
- ATYYGAFIKK
- GTPYWMAPE
- DQLWLVMEFCG
- KAIEIRSV
- YERIKFLV
- AAIKVMDVTEDEEEEI
- PEIRKYKK
- DYSSSSEE
Post-translational modifications for MINK1 Gene
- Autophosphorylated.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for MINK1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for MINK1
- Novus Biologicals Antibodies for MINK1
- Invitrogen Antibodies for MINK1
- antibodies-online Antibodies for MINK1: See all 43
- GeneTex MINK1 antibody for MINK1
Protein Products
-
OriGene Purified Proteins for MINK1
- Search Origene for MassSpec and Protein Over-expression Lysates for MINK1
- Origene Custom Protein Services for MINK1
- Search GeneTex for Proteins for MINK1
Assay Products
- antibodies-online Kits for MINK1: See all 4
Domains & Families for MINK1 Gene
Gene Families for MINK1 Gene
- HGNC:
- IUPHAR :
Protein Domains for MINK1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for MINK1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q8N4C8UniProtKB/Swiss-Prot:
MINK1_HUMAN :- Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
- Family:
-
- Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
Function for MINK1 Gene
Molecular function for MINK1 Gene
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + a protein = ADP + a phosphoprotein.
- UniProtKB/Swiss-Prot Function:
- Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking. Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons. Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates: TANC1 upon stimulation by RAP2A, MBP and SMAD1. Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1.
- UniProtKB/Swiss-Prot Function:
- Isoform 4 can activate the JNK pathway. Involved in the regulation of actin cytoskeleton reorganization, cell-matrix adhesion, cell-cell adhesion and cell migration.
- UniProtKB/Swiss-Prot Induction:
- Activated after Ras induction via a mechanism involving reactive oxygen species.
Enzyme Numbers (IUBMB) for MINK1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004672 | protein kinase activity | IEA,TAS | 10708748 |
| GO:0004674 | protein serine/threonine kinase activity | IDA,IEA | 18930710 |
| GO:0004702 | signal transducer, downstream of receptor, with serine/threonine kinase activity | IBA | -- |
| GO:0005515 | protein binding | IPI | 15469942 |
| GO:0005524 | ATP binding | IEA,ISS | -- |
Phenotypes for MINK1 Gene
- GenomeRNAi human phenotypes for MINK1:
-
- Increased vaccinia virus (VACV) infection
- Decreased viability ratio
- Increased transferrin (TF) endocytosis
- Increased shRNA abundance (Z-score > 2)
- Decreased shRNA abundance (Z-score < -2)
- Decreased substrate adherent cell growth
- Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance
- Decreased cell migration
- Decreased homologous recombination repair frequency
- Increased cell death HMECs cells
- Decreased viability
Animal Model Products
-
Taconic Biosciences Mouse Models for MINK1
- Cyagen custom Knockout/knockin (KOKI) mouse models for MINK1
-
-
ViGene Biosciences lentiviral particle packaged cDNA for MINK1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for MINK1 gene
- Search ViGene Biosciences for MINK1
CRISPR Products
-
OriGene CRISPR knockouts for MINK1
-
Santa Cruz Biotechnology (SCBT) CRISPR for MINK1
- GenScript: Design CRISPR guide RNA sequences for MINK1
miRNA for MINK1 Gene
- miRTarBase miRNAs that target MINK1
-
- hsa-mir-1301-3p (MIRT036060)
- hsa-mir-760 (MIRT036771)
- hsa-mir-744-5p (MIRT037477)
- hsa-mir-18a-3p (MIRT040973)
- hsa-mir-186-5p (MIRT045281)
- hsa-mir-222-3p (MIRT046617)
- hsa-mir-92a-3p (MIRT049099)
- hsa-mir-15a-5p (MIRT077781)
- hsa-mir-16-5p (MIRT077782)
- hsa-mir-15b-5p (MIRT077784)
- hsa-mir-195-5p (MIRT077785)
- hsa-mir-17-5p (MIRT077830)
- hsa-mir-20a-5p (MIRT077831)
- hsa-mir-93-5p (MIRT077832)
- hsa-mir-106a-5p (MIRT077833)
- hsa-mir-106b-5p (MIRT077835)
- hsa-mir-302a-3p (MIRT077836)
- hsa-mir-302b-3p (MIRT077837)
- hsa-mir-302c-3p (MIRT077838)
- hsa-mir-302d-3p (MIRT077839)
- hsa-mir-372-3p (MIRT077840)
- hsa-mir-373-3p (MIRT077841)
- hsa-mir-20b-5p (MIRT077842)
- hsa-mir-520e (MIRT077844)
- hsa-mir-520f-3p (MIRT077845)
- hsa-mir-520a-3p (MIRT077847)
- hsa-mir-526b-3p (MIRT077848)
- hsa-mir-520b (MIRT077850)
- hsa-mir-520c-3p (MIRT077851)
- hsa-mir-519d-3p (MIRT077852)
- hsa-mir-520d-3p (MIRT077853)
- hsa-mir-302e (MIRT077857)
- hsa-mir-3646 (MIRT077859)
- hsa-mir-3662 (MIRT077860)
- hsa-mir-15b-3p (MIRT146636)
- hsa-mir-625-5p (MIRT146648)
- hsa-mir-1275 (MIRT146654)
- hsa-mir-3179 (MIRT146657)
- hsa-mir-3180-3p (MIRT146658)
- hsa-mir-3196 (MIRT146659)
- hsa-mir-3202 (MIRT146661)
- hsa-mir-3180 (MIRT146673)
- hsa-mir-4665-5p (MIRT146684)
- hsa-mir-4747-5p (MIRT146689)
- hsa-mir-5196-5p (MIRT146696)
- hsa-mir-6740-5p (MIRT146703)
- hsa-mir-6783-5p (MIRT146704)
- hsa-mir-6816-5p (MIRT146706)
- hsa-mir-7109-5p (MIRT146714)
- hsa-mir-487b-3p (MIRT440240)
- hsa-mir-6883-5p (MIRT473200)
- hsa-mir-6785-5p (MIRT473201)
- hsa-mir-4728-5p (MIRT473202)
- hsa-mir-6739-5p (MIRT473203)
- hsa-mir-149-3p (MIRT473204)
- hsa-mir-6733-5p (MIRT473205)
- hsa-mir-3153 (MIRT473206)
- hsa-mir-423-5p (MIRT473207)
- hsa-mir-3184-5p (MIRT473208)
- hsa-mir-6754-5p (MIRT473209)
- hsa-mir-4441 (MIRT473210)
- hsa-mir-4270 (MIRT473211)
- hsa-mir-4739 (MIRT473212)
- hsa-mir-4756-5p (MIRT473213)
- hsa-mir-1321 (MIRT473214)
- hsa-mir-583 (MIRT473215)
- hsa-mir-1538 (MIRT493190)
- hsa-mir-4745-3p (MIRT493191)
- hsa-mir-671-5p (MIRT493192)
- hsa-mir-1247-3p (MIRT493193)
- hsa-mir-5572 (MIRT701956)
- hsa-mir-4260 (MIRT701957)
- hsa-mir-450a-2-3p (MIRT701958)
- hsa-mir-3942-3p (MIRT701959)
- hsa-mir-6803-5p (MIRT701960)
- hsa-mir-6751-5p (MIRT701961)
- hsa-mir-5010-5p (MIRT701962)
- hsa-mir-4525 (MIRT701963)
- hsa-mir-3160-5p (MIRT701964)
- hsa-mir-3185 (MIRT701965)
- hsa-mir-4796-3p (MIRT701966)
- hsa-mir-548ah-5p (MIRT701967)
- hsa-mir-3609 (MIRT701968)
miRNA Products
- Search ViGene Biosciences for MINK1
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for MINK1
- Browse OriGene Inhibitory RNA Products For MINK1
-
ViGene Biosciences ready-to-package AAV shRNAs for MINK1 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for MINK1
- VectorBuilder custom plasmid, inducible vectors for MINK1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MINK1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for MINK1
-
ViGene Biosciences adenoviral particle packaged cDNA for MINK1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for MINK1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for MINK1 gene
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MINK1 Gene
Localization for MINK1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for MINK1 Gene
- Cytoplasm. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell projection, axon. Cell projection, dendrite.
- Isoform 4: Golgi apparatus.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| cytosol | 5 |
| golgi apparatus | 5 |
| nucleus | 4 |
| plasma membrane | 3 |
| cytoskeleton | 1 |
| endosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IDA,IEA | 18930710 |
| GO:0005794 | Golgi apparatus | IEA,IDA | 15469942 |
| GO:0005829 | cytosol | TAS | -- |
| GO:0005886 | plasma membrane | IEA | -- |
| GO:0014069 | postsynaptic density | IEA | -- |
Pathways & Interactions for MINK1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Cellular Senescence | ||
| 2 | Angiopoietin Like Protein 8 Regulatory Pathway | ||
| 3 | MAPK signaling pathway | ||
Pathways by source for MINK1 Gene
3 BioSystems pathways for MINK1 Gene
3 Reactome pathways for MINK1 Gene
Interacting Proteins for MINK1 Gene
Selected Interacting proteins:
ENSP00000347427
Q8N4C8-MINK1_HUMAN
for MINK1 Gene via
STRING
IID
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001952 | regulation of cell-matrix adhesion | IMP | 15469942 |
| GO:0006468 | protein phosphorylation | IEA,ISS | -- |
| GO:0006950 | response to stress | ISS | -- |
| GO:0007254 | JNK cascade | TAS | 10708748 |
| GO:0007268 | chemical synaptic transmission | ISS | -- |
Drugs & Compounds for MINK1 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| ADP |
|
Full agonist, Agonist | 58-64-0 |
|
Transcripts for MINK1 Gene
mRNA/cDNA for MINK1 Gene
- (14) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (1) Selected AceView cDNA sequences:
- (13) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for MINK1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for MINK1
-
Santa Cruz Biotechnology (SCBT) CRISPR for MINK1
- GenScript: Design CRISPR guide RNA sequences for MINK1
miRNA Products
- Search ViGene Biosciences for MINK1
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for MINK1
- Browse OriGene Inhibitory RNA Products For MINK1
-
ViGene Biosciences ready-to-package AAV shRNAs for MINK1 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for MINK1
- VectorBuilder custom plasmid, inducible vectors for MINK1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MINK1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14a | · | 14b | ^ | 15 | ^ | 16a | · | 16b | ^ | 17 | ^ | 18a | · | 18b | · | 18c | ^ | 19a | · | 19b | ^ | 20a | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP14: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP15: |
| ExUns: | 20b | · | 20c | ^ | 21 | ^ | 22a | · | 22b | ^ | 23 | ^ | 24a | · | 24b | ^ | 25 | ^ | 26a | · | 26b | · | 26c | · | 26d | ^ | 27 | ^ | 28a | · | 28b | ^ | 29a | · | 29b | · | 29c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||||||||||||||||
| SP2: | |||||||||||||||||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||||||||||
| SP6: | - | - | |||||||||||||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||||||||||||||
| SP8: | |||||||||||||||||||||||||||||||||||||
| SP9: | - | - | |||||||||||||||||||||||||||||||||||
| SP10: | - | ||||||||||||||||||||||||||||||||||||
| SP11: | |||||||||||||||||||||||||||||||||||||
| SP12: | |||||||||||||||||||||||||||||||||||||
| SP13: | |||||||||||||||||||||||||||||||||||||
| SP14: | |||||||||||||||||||||||||||||||||||||
| SP15: |
Expression for MINK1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
This gene is overexpressed in Brain (29.9), Heart (10.6), and Frontal cortex (6.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MINK1 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of MINK1 Gene:
MINK1SOURCE GeneReport for Unigene cluster for MINK1 Gene:
Hs.443417mRNA Expression by UniProt/SwissProt for MINK1 Gene:
Q8N4C8-MINK1_HUMAN
Tissue specificity:
Expressed in the brain, isoform 2 is more abundant than isoform 1. Isoform 3 is ubiquitously expressed. Isoform 1 is most abundant in the skeletal muscle. Isoform 4 is ubiquitously expressed with relative high levels in brain, skeletal muscle, pancreas and testis.
Evidence on tissue expression from TISSUES for MINK1 Gene
- Nervous system(4.7)
- Blood(4.4)
- Liver(4.2)
Primer Products
-
OriGene qPCR primer pairs for MINK1
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MINK1 Gene
Orthologs for MINK1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | MINK1 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | MINK 35 |
|
OneToOne | |
| MINK1 34 |
|
||||
| oppossum (Monodelphis domestica) |
Mammalia | MINK1 35 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | MINK1 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Mink1 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Mink1 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 35 |
|
ManyToMany | |
| chicken (Gallus gallus) |
Aves | NRK 35 |
|
ManyToMany | |
| lizard (Anolis carolinensis) |
Reptilia | MINK1 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | mink1 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | mink1 35 |
|
OneToOne | |
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.538 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | msn 35 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | mig-15 35 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.3520 35 |
|
OneToMany |
- Species where no ortholog for MINK1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for MINK1 Gene
(40) SIMAP similar genes for MINK1 Gene using alignment to 5 proteins:
Variants for MINK1 Gene
| SNP ID | Clin | Chr 17 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| VAR_046061 | A gastric adenocarcinoma sample | ||||
| rs116802199 | Likely benign | 4,897,806(+) | CCCCC(A/C)AACTC | downstream-variant-500B, upstream-variant-2KB, utr-variant-3-prime | |
| rs144554248 | Likely benign | 4,898,126(+) | GGGTG(A/G)GGAAG | downstream-variant-500B, upstream-variant-2KB, utr-variant-3-prime | |
| rs113366718 | Uncertain significance | 4,897,931(+) | TCTCC(A/C)CGCCC | downstream-variant-500B, upstream-variant-2KB, utr-variant-3-prime | |
| rs192238331 | Uncertain significance | 4,897,860(+) | ATTCC(C/T)GACCC | downstream-variant-500B, upstream-variant-2KB, utr-variant-3-prime |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv3088n100 | CNV | gain | 25217958 |
| esv1005973 | CNV | insertion | 20482838 |
| esv1520671 | CNV | insertion | 17803354 |
| esv2537517 | CNV | insertion | 19546169 |
| esv2715558 | CNV | deletion | 23290073 |
| esv2715559 | CNV | deletion | 23290073 |
| esv3341973 | CNV | duplication | 20981092 |
| esv3440715 | CNV | insertion | 20981092 |
| esv3572365 | CNV | gain | 25503493 |
| esv3582499 | CNV | loss | 25503493 |
| esv3639796 | CNV | loss | 21293372 |
| nsv1953 | CNV | insertion | 18451855 |
| nsv474658 | CNV | novel sequence insertion | 20440878 |
| nsv480316 | CNV | novel sequence insertion | 20440878 |
| nsv480688 | CNV | novel sequence insertion | 20440878 |
| nsv480726 | CNV | novel sequence insertion | 20440878 |
| nsv480878 | CNV | novel sequence insertion | 20440878 |
| nsv509647 | CNV | insertion | 20534489 |
| nsv574273 | CNV | gain | 21841781 |
| nsv574275 | CNV | gain | 21841781 |
| nsv833346 | CNV | loss | 17160897 |
| nsv833347 | CNV | loss | 17160897 |
| nsv833349 | CNV | loss | 17160897 |
| nsv833350 | CNV | loss | 17160897 |
| nsv952112 | CNV | deletion | 24416366 |
| nsv952113 | CNV | deletion | 24416366 |
| nsv960043 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
4.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
8.48;
85.80% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for MINK1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MINK1
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MINK1 Gene
Disorders for MINK1 Gene
Relevant External Links for MINK1
No disorders were found for MINK1 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MINK1 Gene
Publications for MINK1 Gene
- Identification and functional characterization of a novel human misshapen/Nck interacting kinase-related kinase, hMINK beta. (PMID: 15469942) Hu Y. … Xu X. (J. Biol. Chem. 2004) 3 4 22 64
- Molecular cloning of MINK, a novel member of mammalian GCK family kinases, which is up-regulated during postnatal mouse cerebral development. (PMID: 10708748) Dan I. … Kusumi A. (FEBS Lett. 2000) 2 3 4 64
- Smad inhibition by the Ste20 kinase Misshapen. (PMID: 21690388) Kaneko S. … Xu L. (Proc. Natl. Acad. Sci. U.S.A. 2011) 3 4 64
- Molecular genetic analysis of long QT syndrome in Norway indicating a high prevalence of heterozygous mutation carriers. (PMID: 18752142) Berge K.E. … Leren T.P. (Scand. J. Clin. Lab. Invest. 2008) 3 46 64
- MINK is a Rap2 effector for phosphorylation of the postsynaptic scaffold protein TANC1. (PMID: 18930710) Nonaka H. … Kariya K. (Biochem. Biophys. Res. Commun. 2008) 3 4 64
Products for MINK1 Gene
- Browse R&D Systems for Antibodies
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- Custom Antibody ServicesOriGene Antibodies for MINK1
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for MINK1
- Search Origene for MassSpec and Protein Over-expression Lysates for MINK1
- Origene Custom Protein Services for MINK1
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for MINK1
- Browse OriGene Inhibitory RNA Products For MINK1
- OriGene qPCR primer pairs for MINK1
- OriGene CRISPR knockouts for MINK1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For MINK1
- GenScript: Next-day shipping cDNA ORF clone for MINK1 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for MINK1
- GenScript Custom Assay Services for MINK1
- GenScript Custom overexpressing Cell Line Services for MINK1
- GenScript: Design CRISPR guide RNA sequences for MINK1
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for MINK1
- Browse Sino Biological cDNA Clones
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- Sino Biological Antibodies
- Sino Biological ELISA Kits and Pair Sets
- Sino Biological Cell Lysates
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- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for MINK1
- Novus Biologicals proteins and lysates for MINK1
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Taconic Biosciences Mouse Models for MINK1
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for MINK1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for MINK1
- antibodies-online Antibodies for MINK1: See all 43
- antibodies-online Kits for MINK1: See all 4
- Search antibodies-online for proteins
- Search antibodies-online for peptides
- GeneTex MINK1 antibody for MINK1
- Search GeneTex for Proteins for MINK1
- ViGene Biosciences adenoviral particle packaged cDNA for MINK1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for MINK1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for MINK1 gene
- Search ViGene Biosciences for MINK1
- Horizon Cell Lines for MINK1
- Cyagen custom Knockout/knockin (KOKI) mouse models for MINK1
- VectorBuilder custom plasmid, inducible vectors for MINK1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MINK1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for MINK1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
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- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
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- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
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- (133) NCBI Bookshelf
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- (135) Gene Damage Index
- (136) ViGene Biosciences
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- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer