MINK1 Gene
protein-coding GIFtS: 56
GCID: GC17P004736
|
|
misshapen-like kinase 1(Previous name: misshapen-like kinase 1 (zebrafish) )
| |
Aliases
for MINK1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Misshapen-Like Kinase 11 2 | | MAPK/ERK Kinase Kinase Kinase 62 3 | | MINK1 2 3 5 | | MEK Kinase Kinase 62 3 | | B551 2 3 | | MEKKK 62 3 | | MAP4K61 2 3 | | EC 2.7.11.13 8 | | YSK21 2 3 | | Misshapen-Like Kinase 1 (Zebrafish)1 | | ZC31 2 3 | | HMINK1 | | GCK Family Kinase MiNK2 3 | | HMINKbeta1 | | Misshapen/NIK-Related Kinase2 3 | | Serine/Threonine Protein Kinase2 | | Mitogen-Activated Protein Kinase Kinase Kinase Kinase 62 3 | | EC 2.7.118 |
Export aliases for MINK1 gene to outside databasesPrevious GC identifer: GC17P004684 |
Summaries
for MINK1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MINK1:
This gene encodes a serine/threonine kinase belonging to the germinal center kinase (GCK) family. The protein isstructurally similar to the kinases that are related to NIK and may belong to a distinct subfamily of NIK-relatedkinases within the GCK family. Studies of the mouse homolog indicate an up-regulation of expression in the course ofpostnatal mouse cerebral development and activation of the cJun N-terminal kinase (JNK) and the p38 pathways.Alternative splicing occurs at this locus and four transcript variants encoding distinct isoforms have beenidentified. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: MINK1_HUMAN, Q8N4C8Function: Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transductionto control neuronal structure and AMPA receptor trafficking. Required for normal synaptic density, dendritecomplexity, as well as surface AMPA receptor expression in hippocampal neurons. Can activate the JNK and MAPK14/p38pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERKpathway. Phosphorylates: TANC1 upon stimulation by RAP2A, MBP and SMAD1. Has an essential function in negativeselection of thymocytes, perhaps by coupling NCK1 to activation of JNK1Function: Isoform 4 can activate the JNK pathway. Involved in the regulation of actin cytoskeleton reorganization,cell-matrix adhesion, cell-cell adhesion and cell migration
Gene Wiki entry for MINK1
|
Genomic Views
for MINK1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010718.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MINK1 gene promoter:
AP-1 ATF-2 c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for MINK1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MINK1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17p13.2 Ensembl cytogenetic band: 17p13.2 HGNC cytogenetic band: 17p13.2MINK1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P004736: view genomic region
(about GC identifiers)
Start:
|
4,736,635 bp from pter |
End:
|
4,801,356 bp from pter |
Size:
|
64,722 bases |
Orientation:
|
plus strand |
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Proteins
for MINK1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MINK1_HUMAN, Q8N4C8 (See
protein sequence)Recommended Name: Misshapen-like kinase 1 Size: 1332 amino acids; 149822 Da
Cofactor: Magnesium (By similarity)
Subunit: Interacts with TANC1 (By similarity). Interacts with RAP2A. Isoform 4 interacts with NCK1
Subcellular location: Cytoplasm. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density (Bysimilarity). Cell projection, axon (By similarity). Cell projection, dendrite (By similarity)
Subcellular location: Isoform 4: Golgi apparatus
Secondary accessions: D3DTK3 D3DTK4 Q5U8Z0 Q9P1X1 Q9P2R8Alternative splicing: 5 isoforms: Q8N4C8-1 Q8N4C8-2 Q8N4C8-3 Q8N4C8-4 Q8N4C8-5 Explore the universe of human proteins at neXtProt for MINK1: NX_Q8N4C8
Post-translational modifications:
Autophosphorylated1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8N4C8
4/32 DME Specific Peptides for MINK1 (Q8N4C8) (see all 32)
MINK1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (4 alternative transcripts):
NP_001020108.1 NP_056531.1 NP_722549.2 NP_733763.1
ENSEMBL proteins: ENSP00000347427 ENSP00000269296 ENSP00000461500 ENSP00000406487 ENSP00000459269 ENSP00000459699 ENSP00000459102
Human Recombinant Protein Products for MINK1:
Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table
MINK1 for ontologies About GeneDecksing
MINK1 Antibody Products:
Assay Products for MINK1: |
Protein
Domains /
Families
for MINK1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MINK1 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q8N4C8ProtoNet protein and cluster: Q8N4C8 1 Blocks protein family: IPB001180 Citron-like
UniProtKB/Swiss-Prot: MINK1_HUMAN, Q8N4C8Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamilySimilarity: Contains 1 CNH domainSimilarity: Contains 1 protein kinase domain |
Function
for MINK1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: MINK1_HUMAN, Q8N4C8Function: Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transductionto control neuronal structure and AMPA receptor trafficking. Required for normal synaptic density, dendritecomplexity, as well as surface AMPA receptor expression in hippocampal neurons. Can activate the JNK and MAPK14/p38pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERKpathway. Phosphorylates: TANC1 upon stimulation by RAP2A, MBP and SMAD1. Has an essential function in negativeselection of thymocytes, perhaps by coupling NCK1 to activation of JNK1Function: Isoform 4 can activate the JNK pathway. Involved in the regulation of actin cytoskeleton reorganization,cell-matrix adhesion, cell-cell adhesion and cell migrationCatalytic activity: ATP + a protein = ADP + a phosphoproteinInduction: Activated after Ras induction via a mechanism involving reactive oxygen species Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table
MINK1 for ontologies About GeneDecksing
Phenotypes:
3 GenomeRNAi human phenotypes for MINK1:
1 MGI phenotypic allele  for Mink1 (no phenotypes)
MINK1 for phenotypes About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MINK1 (see all 9)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MINK1 (see all 4)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 4): MINK1 (NM_001024937) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MINK1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MINK1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MINK1 |
|
Pathways & Interactions
for MINK1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Insulin Signaling | | | 2 | MAPK signaling pathway | |
2  BioSystems Pathways for MINK1
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MINK1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 15)
5/18 Interacting proteins for MINK1 (Q8N4C83 ENSP000003474274) via UniProtKB, MINT, STRING, and/or I2D (see all 18)About this table
Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15): About this table
MINK1 for ontologies About GeneDecksing
|
Drugs & Compounds
for MINK1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MINK1
1 HMDB Compound for MINK1 About this table
Search CenterWatch for drugs/clinical trials and news about MINK1
|
Transcripts
for MINK1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MINK1 gene (4 alternative transcripts): NM_001024937.3 NM_015716.4 NM_153827.4 NM_170663.4 Unigene Cluster for MINK1: Misshapen-like kinase 1 Hs.443417 [show with all ESTs]Unigene Representative Sequence: BC09468613 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000355280(uc010vsl.2 uc010vsm.2 uc010vsn.2) ENST00000572330
ENST00000347992(uc010vsk.2) ENST00000574453(uc010vso.2) ENST00000453408
ENST00000577021 ENST00000571207(uc010vsp.2) ENST00000572629 ENST00000571526
ENST00000572304 ENST00000574871 ENST00000575511 ENST00000576037
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MINK1 (see all 9)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MINK1 (see all 4)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 4): MINK1 (NM_001024937) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MINK1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MINK1 |
Additional cDNA sequence: AB035698.1 AB041926.1 AF218033.1 AY775058.1 BC028888.1 BC034673.1 BC094686.1 17 DOTS entries: DT.450495 DT.101966234 DT.100794683 DT.95135307 DT.100794679 DT.100794681 DT.97859616 DT.100794680 DT.95084687 DT.102838682 DT.95135308 DT.92409449 DT.120991493 DT.120991431 DT.97859617 DT.121427451 DT.95332072 24/57 AceView cDNA sequences (see all 57): BM967105 BM717445 BM715816 BF868921 AI125161 AL157418 CA454128 BM718065 BI908161 AA366908 BF724524 BG680567 BM701243 AW751287 CK823412 BQ716738 CK823411 BM893807 BM722585 BU838349 BG757547 AW802152 BM906355 AI087028
GeneLoc Exon Structure
5/15 Alternative Splicing Database (ASD) splice patterns (SP) for MINK1 (see all 15) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14a | · | 14b | ^ | 15 | ^ | 16a | · | 16b | ^ | 17 | ^ | 18a | · | 18b | · | 18c | ^ | 19a | · | 19b | ^ | 20a | · |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 20b | · | 20c | ^ | 21 | ^ | 22a | · | 22b | ^ | 23 | ^ | 24a | · | 24b | ^ | 25 | ^ | 26a | · | 26b | · | 26c | · | 26d | ^ | 27 | ^ | 28a | · | 28b | ^ | 29a | · | 29b | · | 29c |
|---|
|
| SP1: | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for MINK1
|
Expression
for MINK1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MINK1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCCTTCCCCG
About this image
See MINK1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MINK1
SOURCE GeneReport for Unigene cluster: Hs.443417
UniProtKB/Swiss-Prot: MINK1_HUMAN, Q8N4C8Tissue specificity: Expressed in the brain, isoform 2 is more abundant than isoform 1. Isoform 3 is ubiquitouslyexpressed. Isoform 1 is most abundant in the skeletal muscle. Isoform 4 is ubiquitously expressed with relative highlevels in brain, skeletal muscle, pancreas and testis
SABiosciences Custom PCR Arrays for MINK1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MINK1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MINK1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MINK1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MINK1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MINK1 |
Orthologs
for MINK1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for MINK1 gene from 6/22 species (see all 22) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
MINK16 |
-- |
77(a) |
1 ↔ 1 |
GL344055.1(1901-56547) |
zebrafish
(Danio rerio) |
Actinopterygii |
mink16 |
misshapen-like kinase 1 |
73(a) |
1 ↔ 1 |
5(39906030-39985212) |
fruit fly
(Drosophila melanogaster) |
Insecta |
msn6 |
misshapen |
40(a) |
1 → many |
3L(2554847-2586540) |
worm
(Caenorhabditis elegans) |
Secernentea |
mig-151 |
Protein MIG-15 |
59(n)
63.46(a) |
|
181248 NM_001029802.2 NP_001024973.1 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
SIK16 |
protein kinase domain-containing protein |
19(a) |
1 → many |
1(26020089-26026171) |
rice
(Oryza sativa) |
Liliopsida |
-- |
STE_PAK_Ste20_KHSh_GCKh_HPKh.1 - STE kinases inclu... |
18(a) |
1 → many |
3(31132935-31141859) |
ENSEMBL Gene Tree for MINK1 (if available)
TreeFam Gene Tree for MINK1 (if available) |
Paralogs
for MINK1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MINK1 gene
- TAOK22 MAP4K52 TAOK32 NRK2 TNIK2 MAP4K22 MAP4K12 MAP4K32
- MAP4K42 TAOK12 STK102 SLK2
18/41 SIMAP similar genes for MINK1 using alignment to 5 protein entries: MINK1_HUMAN (see all proteins)
(see all similar genes):MINK MAP4K5 TNIK MYO3A PHKG2 MAP4K2
MAP4K4 STK25 PAK4 MYO3B PAK2 STK3
TAOK3 MST4 NEK9 STK24 STK4/SLC36AL fusion DKFZp686J1430
MINK1 for paralogs About GeneDecksing
|
Genomic Variants
for MINK1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MINK1 (4736635 - 4801356 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 16 variations for MINK1
12 CNVs: 35471 4986 77505 35472 35470 88325 4987 35473 4985 35474 88323 35475
4 Indels: 77507 102392 77506 88324 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MINK1 |
|
Disorders
/ Diseases
for MINK1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MINK1 for disorders About GeneDecksing
OMIM gene information: 609426
OMIM disorders: --
10  diseases for MINK1: About MalaCardscerebritis supranuclear palsy progressive supranuclear palsy long qt syndrome
atrophic rhinitis atrial fibrillation balanitis rhinitis
choroiditis neuronitis
Human Genome Epidemiology (HuGE) Navigator: MINK1 (3 documents)
Export disorders for MINK1 gene to outside databases
|
Publications
for MINK1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MINK1 gene, integrated from 9 sources (see all 37):
(articles sorted by number of sources associating them with MINK1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Molecular cloning of MINK, a novel member of mammalian GCK family kinases, which is up-regulated during postnatal mouse cerebral development. (PubMed id 10708748)1, 2, 3 Dan I.... Kusumi A. (2000)
- Identification and functional characterization of a novel human misshapen/Nck interacting kinase-related kinase, hMINK beta. (PubMed id 15469942)1, 2, 9 Hu Y.... Xu X. (2004)
- MINK is a Rap2 effector for phosphorylation of the postsynaptic scaffold protein TANC1. (PubMed id 18930710)1, 2 Nonaka H....Kariya K. (2008)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Overlapping of MINK and CHRNE gene loci in the course of mammalian evolution. (PubMed id 12087176)1, 3 Dan I.... Kusumi A. (2002)
- Computational and experimental studies on human misshapen/NIK-related kinase MINK-1. (PubMed id 15032605)1, 9 Qu K....Xu D. (2004)
- Misshapen-like kinase 1 (MINK1) is a novel component o f striatin-interacting phosphatase and kinase (STRIPAK) and is required for the completion of cytokinesis. (PubMed id 22665485)1 Hyodo T....Senga T. (2012)
- Mink1 regulates I^-catenin-independent Wnt signaling v ia Prickle phosphorylation. (PubMed id 22037766)1 Daulat A.M....Angers S. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
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External Searches for MINK1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing MINK1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing MINK1 gene
(According to HUGE)
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Specialized Databases showing MINK1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for MINK1 | Pharmacogenomics, SNPs, Pathways |
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| Patent Information for MINK1 gene:
Search GeneIP for patents involving MINK1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for MINK1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for MINK1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MINK1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MINK1 | | | OriGene Protein Over-expression Lysate for MINK1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MINK1 | | OriGene 3'-UTR Clone for MINK1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MINK1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MINK1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for MINK1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for MINK1 | | OriGene Custom Protein Services for MINK1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MINK1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MINK1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MINK1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MINK1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MINK1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MINK1 |
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| | | | Search Tocris compounds for MINK1 |
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 | | | MINK1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MINK1 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for MINK1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MINK1 |
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