Aliases for MINK1 Gene
Aliases for MINK1 Gene
External Ids for MINK1 Gene
- HGNC: 17565
- Entrez Gene: 50488
- Ensembl: ENSG00000141503
- OMIM: 609426
- UniProtKB: Q8N4C8
Previous GeneCards Identifiers for MINK1 Gene
- GC17P004684
- GC17P004736
Summaries for MINK1 Gene
-
This gene encodes a serine/threonine kinase belonging to the germinal center kinase (GCK) family. The protein is structurally similar to the kinases that are related to NIK and may belong to a distinct subfamily of NIK-related kinases within the GCK family. Studies of the mouse homolog indicate an up-regulation of expression in the course of postnatal mouse cerebral development and activation of the cJun N-terminal kinase (JNK) and the p38 pathways. [provided by RefSeq, Mar 2016]
GeneCards Summary for MINK1 Gene
MINK1 (Misshapen Like Kinase 1) is a Protein Coding gene. Among its related pathways are Cellular Senescence and MAPK signaling pathway. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAP4K3.
UniProtKB/Swiss-Prot for MINK1 Gene
-
Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking. Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons. Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates: TANC1 upon stimulation by RAP2A, MBP and SMAD1. Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1.
-
Isoform 4 can activate the JNK pathway. Involved in the regulation of actin cytoskeleton reorganization, cell-matrix adhesion, cell-cell adhesion and cell migration.
No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MINK1 Gene
Genomics for MINK1 Gene
Regulatory Elements for MINK1 Gene
Enhancers for MINK1 Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around MINK1 on UCSC Golden Path with GeneCards custom track
Promoters for MINK1 Gene
| Ensembl Regulatory Elements (ENSRs) | TSS Distance (bp) | Size (bp) | Binding Sites for Transcription Factors within promoters |
|---|
ENSRs around MINK1 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the MINK1 gene promoter:
Regulatory Element Products
Genomic Location for MINK1 Gene
- Chromosome:
- 17
- Start:
- 4,833,340 bp from pter
- End:
- 4,898,061 bp from pter
- Size:
- 64,722 bases
- Orientation:
- Plus strand
Genomic View for MINK1 Gene
Genes around MINK1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17p13.2 by Ensembl
- 17p13.2 by Entrez Gene
- 17p13.2 by HGNC
MINK1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MINK1 Gene
Proteins for MINK1 Gene
-
Protein details for MINK1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8N4C8-MINK1_HUMAN
- Recommended name:
- Misshapen-like kinase 1
- Protein Accession:
- Q8N4C8
- D3DTK3
- D3DTK4
- Q5U8Z0
- Q9P1X1
- Q9P2R8
Protein attributes for MINK1 Gene
- Size:
- 1332 amino acids
- Molecular mass:
- 149822 Da
- Cofactor:
- Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Quaternary structure:
-
- Interacts with TANC1 (By similarity). Interacts with RAP2A. Isoform 4 interacts with NCK1.
Protein Expression for MINK1 Gene
Selected DME Specific Peptides for MINK1 Gene
- Q8N4C8:
-
- FIGTPYWMAPEV
- PFIRDQP
- EGVYVNTYGR
- VVLQWGEMP
- TGHLDGVFMHK
- VIHRDIKGQNVLLT
- SVVNVNPTN
- MEFCGAGS
- EILCAALWGVNLL
- RNDKVFF
- LRDPAGIFEL
- VGNGTYGQVYKGRHVKTGQLAAIKVMDVT
- ILHNDPEVEKKQGW
- PRLKSKKWSKKF
- ERQVRIQLKDHIDR
- GITAIEMAEGAPPLC
- RVYYLSWLR
- GLMLLDRSGQGKVY
- LNLLITISG
- ETEYEYSGSEEE
- YAWAPKPYHKFM
- WMAPEVI
- VKLVDFGVSAQL
- RRRFQQMDVLEGLN
- ATYYGAFIKK
- GTPYWMAPE
- DQLWLVMEFCG
- KAIEIRSV
- YERIKFLV
- AAIKVMDVTEDEEEEI
- PEIRKYKK
- DYSSSSEE
Post-translational modifications for MINK1 Gene
- Autophosphorylated.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for MINK1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for MINK1
- Invitrogen Antibodies for MINK1
- antibodies-online Antibodies for MINK1: See all 43
- GeneTex MINK1 antibody for MINK1
-
Santa Cruz Biotechnology (SCBT) Antibodies for MINK1
Protein Products
- EMD Millipore Purified and/or Recombinant MINK1 Protein
-
OriGene Purified Proteins for MINK1
- Search Origene for MassSpec and Protein Over-expression Lysates for MINK1
- Origene Custom Protein Services for MINK1
- Search GeneTex for Proteins for MINK1
Assay Products
- antibodies-online Kits for MINK1: See all 4
Domains & Families for MINK1 Gene
Gene Families for MINK1 Gene
- IUPHAR :
Protein Domains for MINK1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for MINK1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q8N4C8UniProtKB/Swiss-Prot:
MINK1_HUMAN :- Contains 1 CNH domain.
- Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
- Domain:
-
- Contains 1 CNH domain.
- Contains 1 protein kinase domain.
- Family:
-
- Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
Function for MINK1 Gene
Molecular function for MINK1 Gene
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + a protein = ADP + a phosphoprotein.
- UniProtKB/Swiss-Prot Function:
- Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking. Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons. Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates: TANC1 upon stimulation by RAP2A, MBP and SMAD1. Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1.
- UniProtKB/Swiss-Prot Function:
- Isoform 4 can activate the JNK pathway. Involved in the regulation of actin cytoskeleton reorganization, cell-matrix adhesion, cell-cell adhesion and cell migration.
- UniProtKB/Swiss-Prot Induction:
- Activated after Ras induction via a mechanism involving reactive oxygen species.
Enzyme Numbers (IUBMB) for MINK1 Gene
- EC 2.7.11.1 63 4
- EC 2.7.11 63
Phenotypes for MINK1 Gene
- GenomeRNAi human phenotypes for MINK1:
-
- Increased vaccinia virus (VACV) infection
- Increased transferrin (TF) endocytosis
- Increased shRNA abundance (Z-score > 2)
- Decreased shRNA abundance (Z-score < -2)
- Decreased substrate adherent cell growth
- Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance
- Decreased cell migration
- Decreased homologous recombination repair frequency
- Increased cell death HMECs cells
- Decreased viability
Animal Model Products
-
Taconic Biosciences Mouse Models for MINK1
-
ViGene Biosciences lentiviral particle packaged cDNA for MINK1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for MINK1 gene
- Search ViGene Biosciences for MINK1
CRISPR Products
-
OriGene CRISPR knockouts for MINK1
-
Santa Cruz Biotechnology (SCBT) CRISPR for MINK1
- GenScript: Design CRISPR guide RNA sequences for MINK1
miRNA for MINK1 Gene
- miRTarBase miRNAs that target MINK1
-
- hsa-mir-1301-3p (MIRT036060)
- hsa-mir-760 (MIRT036771)
- hsa-mir-744-5p (MIRT037477)
- hsa-mir-18a-3p (MIRT040973)
- hsa-mir-186-5p (MIRT045281)
- hsa-mir-222-3p (MIRT046617)
- hsa-mir-92a-3p (MIRT049099)
- hsa-mir-15a-5p (MIRT077781)
- hsa-mir-16-5p (MIRT077782)
- hsa-mir-15b-5p (MIRT077784)
- hsa-mir-195-5p (MIRT077785)
- hsa-mir-17-5p (MIRT077830)
- hsa-mir-20a-5p (MIRT077831)
- hsa-mir-93-5p (MIRT077832)
- hsa-mir-106a-5p (MIRT077833)
- hsa-mir-106b-5p (MIRT077835)
- hsa-mir-302a-3p (MIRT077836)
- hsa-mir-302b-3p (MIRT077837)
- hsa-mir-302c-3p (MIRT077838)
- hsa-mir-302d-3p (MIRT077839)
- hsa-mir-372-3p (MIRT077840)
- hsa-mir-373-3p (MIRT077841)
- hsa-mir-20b-5p (MIRT077842)
- hsa-mir-520e (MIRT077844)
- hsa-mir-520f-3p (MIRT077845)
- hsa-mir-520a-3p (MIRT077847)
- hsa-mir-526b-3p (MIRT077848)
- hsa-mir-520b (MIRT077850)
- hsa-mir-520c-3p (MIRT077851)
- hsa-mir-519d-3p (MIRT077852)
- hsa-mir-520d-3p (MIRT077853)
- hsa-mir-302e (MIRT077857)
- hsa-mir-3646 (MIRT077859)
- hsa-mir-3662 (MIRT077860)
- hsa-mir-15b-3p (MIRT146636)
- hsa-mir-625-5p (MIRT146648)
- hsa-mir-1275 (MIRT146654)
- hsa-mir-3179 (MIRT146657)
- hsa-mir-3180-3p (MIRT146658)
- hsa-mir-3196 (MIRT146659)
- hsa-mir-3202 (MIRT146661)
- hsa-mir-3180 (MIRT146673)
- hsa-mir-4665-5p (MIRT146684)
- hsa-mir-4747-5p (MIRT146689)
- hsa-mir-5196-5p (MIRT146696)
- hsa-mir-6740-5p (MIRT146703)
- hsa-mir-6783-5p (MIRT146704)
- hsa-mir-6816-5p (MIRT146706)
- hsa-mir-7109-5p (MIRT146714)
- hsa-mir-487b-3p (MIRT440240)
- hsa-mir-6883-5p (MIRT473200)
- hsa-mir-6785-5p (MIRT473201)
- hsa-mir-4728-5p (MIRT473202)
- hsa-mir-6739-5p (MIRT473203)
- hsa-mir-149-3p (MIRT473204)
- hsa-mir-6733-5p (MIRT473205)
- hsa-mir-3153 (MIRT473206)
- hsa-mir-423-5p (MIRT473207)
- hsa-mir-3184-5p (MIRT473208)
- hsa-mir-6754-5p (MIRT473209)
- hsa-mir-4441 (MIRT473210)
- hsa-mir-4270 (MIRT473211)
- hsa-mir-4739 (MIRT473212)
- hsa-mir-4756-5p (MIRT473213)
- hsa-mir-1321 (MIRT473214)
- hsa-mir-583 (MIRT473215)
- hsa-mir-1538 (MIRT493190)
- hsa-mir-4745-3p (MIRT493191)
- hsa-mir-671-5p (MIRT493192)
- hsa-mir-1247-3p (MIRT493193)
- hsa-mir-5572 (MIRT701956)
- hsa-mir-4260 (MIRT701957)
- hsa-mir-450a-2-3p (MIRT701958)
- hsa-mir-3942-3p (MIRT701959)
- hsa-mir-6803-5p (MIRT701960)
- hsa-mir-6751-5p (MIRT701961)
- hsa-mir-5010-5p (MIRT701962)
- hsa-mir-4525 (MIRT701963)
- hsa-mir-3160-5p (MIRT701964)
- hsa-mir-3185 (MIRT701965)
- hsa-mir-4796-3p (MIRT701966)
- hsa-mir-548ah-5p (MIRT701967)
- hsa-mir-3609 (MIRT701968)
miRNA Products
- Search ViGene Biosciences for MINK1
Inhibitory RNA Products
- Origene RNAi, shRNA, mouse_rna, and siRNA products in human, mouse, rat for MINK1
- Browse OriGene Inhibitory RNA Products For MINK1
-
ViGene Biosciences ready-to-package AAV shRNAs for MINK1 gene
Clone Products
- OriGene clones in human for MINK1
- OriGene ORF clones in human,mouse,rat for MINK1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for MINK1
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for MINK1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for MINK1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for MINK1 gene
Flow Cytometry Products
No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MINK1 Gene
Localization for MINK1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for MINK1 Gene
- Cytoplasm. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell projection, axon. Cell projection, dendrite.
- Isoform 4: Golgi apparatus.
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| extracellular | 5 |
| golgi apparatus | 5 |
| nucleus | 4 |
| plasma membrane | 3 |
| cytoskeleton | 1 |
| endosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005829 | cytosol | TAS | -- |
| GO:0030425 | dendrite | IEA | -- |
| GO:0070062 | extracellular exosome | IDA | 19056867 |
Pathways & Interactions for MINK1 Gene
More details on SuperPathways for MINK1| Superpath | Contained pathways | ||
|---|---|---|---|
| 1 | Cellular Senescence | ||
| 2 | Insulin Signaling | ||
| 3 | MAPK signaling pathway |
Pathways by source for MINK1 Gene
2 BioSystems pathways for MINK1 Gene
3 Reactome pathways for MINK1 Gene
Interacting Proteins for MINK1 Gene
Selected Interacting proteins:
ENSP00000347427
Q8N4C8-MINK1_HUMAN
for MINK1 Gene via
STRING
UniProtKB
I2D
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001952 | regulation of cell-matrix adhesion | IMP | 15469942 |
| GO:0006468 | protein phosphorylation | IEA,ISS | -- |
| GO:0006950 | response to stress | ISS | -- |
| GO:0007268 | synaptic transmission | ISS | -- |
| GO:0007275 | multicellular organism development | ISS | -- |
Drugs & Compounds for MINK1 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| ADP |
|
Full agonist, Agonist | 58-64-0 |
|
Transcripts for MINK1 Gene
mRNA/cDNA for MINK1 Gene
- (20) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (57) Selected AceView cDNA sequences:
- (13) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for MINK1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for MINK1
-
Santa Cruz Biotechnology (SCBT) CRISPR for MINK1
- GenScript: Design CRISPR guide RNA sequences for MINK1
miRNA Products
- Search ViGene Biosciences for MINK1
Inhibitory RNA Products
- Origene RNAi, shRNA, mouse_rna, and siRNA products in human, mouse, rat for MINK1
- Browse OriGene Inhibitory RNA Products For MINK1
-
ViGene Biosciences ready-to-package AAV shRNAs for MINK1 gene
Clone Products
- OriGene clones in human for MINK1
- OriGene ORF clones in human,mouse,rat for MINK1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for MINK1
Flow Cytometry Products
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14a | · | 14b | ^ | 15 | ^ | 16a | · | 16b | ^ | 17 | ^ | 18a | · | 18b | · | 18c | ^ | 19a | · | 19b | ^ | 20a | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP14: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP15: |
| ExUns: | 20b | · | 20c | ^ | 21 | ^ | 22a | · | 22b | ^ | 23 | ^ | 24a | · | 24b | ^ | 25 | ^ | 26a | · | 26b | · | 26c | · | 26d | ^ | 27 | ^ | 28a | · | 28b | ^ | 29a | · | 29b | · | 29c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||||||||||||||||
| SP2: | |||||||||||||||||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||||||||||
| SP6: | - | - | |||||||||||||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||||||||||||||
| SP8: | |||||||||||||||||||||||||||||||||||||
| SP9: | - | - | |||||||||||||||||||||||||||||||||||
| SP10: | - | ||||||||||||||||||||||||||||||||||||
| SP11: | |||||||||||||||||||||||||||||||||||||
| SP12: | |||||||||||||||||||||||||||||||||||||
| SP13: | |||||||||||||||||||||||||||||||||||||
| SP14: | |||||||||||||||||||||||||||||||||||||
| SP15: |
Expression for MINK1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
This gene is overexpressed in Brain (29.9), Heart (10.6), and Frontal cortex (6.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MINK1 Gene
SOURCE GeneReport for Unigene cluster for MINK1 Gene Hs.443417
mRNA Expression by UniProt/SwissProt for MINK1 Gene
Q8N4C8-MINK1_HUMAN
Tissue specificity:
Expressed in the brain, isoform 2 is more abundant than isoform 1. Isoform 3 is ubiquitously expressed. Isoform 1 is most abundant in the skeletal muscle. Isoform 4 is ubiquitously expressed with relative high levels in brain, skeletal muscle, pancreas and testis.
- Elite partner
Primer Products
-
OriGene qPCR primer pairs for MINK1
No data available for mRNA differential expression in normal tissues for MINK1 Gene
Orthologs for MINK1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | MINK1 35 |
|
||
| MINK1 36 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | MINK1 35 |
|
||
| MINK 36 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Mink1 35 |
|
||
| Mink1 16 |
|
||||
| Mink1 36 |
|
OneToOne | |||
| chimpanzee (Pan troglodytes) |
Mammalia | MINK1 35 |
|
||
| MINK1 36 |
|
OneToOne | |||
| rat (Rattus norvegicus) |
Mammalia | Mink1 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | MINK1 36 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 36 |
|
ManyToMany | |
| chicken (Gallus gallus) |
Aves | NRK 36 |
|
ManyToMany | |
| lizard (Anolis carolinensis) |
Reptilia | MINK1 36 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | mink1 35 |
|
||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.538 35 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | mink1 36 |
|
OneToOne | |
| fruit fly (Drosophila melanogaster) |
Insecta | msn 36 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | mig-15 36 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.3520 36 |
|
OneToMany |
- Species with no ortholog for MINK1:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for MINK1 Gene
(40) SIMAP similar genes for MINK1 Gene using alignment to 5 proteins:
Variants for MINK1 Gene
| SNP ID | Clin | Chr 17 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs56131206 | - | 4,890,709(+) | ATCCC(A/G)CTGAC | reference, missense | |
| VAR_040800 | - | ||||
| rs11556634 | - | 4,892,979(+) | TCCAG(A/C/G/T)CTCCT | reference, missense | |
| rs11556635 | - | 4,892,991(+) | CAAAC(C/T)GGACA | reference, missense | |
| rs2302319 | - | 4,894,010(-) | GCTGA(C/T)GCTGT | reference, missense |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv833346 | CNV | Loss | 17160897 |
| nsv833347 | CNV | Loss | 17160897 |
| esv2537517 | CNV | Insertion | 19546169 |
| esv1520671 | CNV | Insertion | 17803354 |
| nsv833349 | CNV | Loss | 17160897 |
| esv2715558 | CNV | Deletion | 23290073 |
| nsv1953 | CNV | Insertion | 18451855 |
| nsv509647 | CNV | Insertion | 20534489 |
| nsv907619 | CNV | Loss | 21882294 |
| nsv907620 | CNV | Loss | 21882294 |
| esv1005973 | CNV | Insertion | 20482838 |
| esv2715559 | CNV | Deletion | 23290073 |
| nsv833350 | CNV | Loss | 17160897 |
Residual Variation Intolerance Score:
4.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
8.48;
85.80% of all genes are more intolerant (likely to be disease-causing)
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for MINK1 Gene
Disorders for MINK1 Gene
Relevant External Links for MINK1
No disorders were found for MINK1 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MINK1 Gene
Publications for MINK1 Gene
- Molecular cloning of MINK, a novel member of mammalian GCK family kinases, which is up-regulated during postnatal mouse cerebral development. (PMID: 10708748) Dan I. … Kusumi A. (FEBS Lett. 2000) 2 3 4 67
- Computational and experimental studies on human misshapen/NIK-related kinase MINK-1. (PMID: 15032605) Qu K. … Xu D. (Curr. Med. Chem. 2004) 3 23
- Identification and functional characterization of a novel human misshapen/Nck interacting kinase-related kinase, hMINK beta. (PMID: 15469942) Hu Y. … Xu X. (J. Biol. Chem. 2004) 3 23
- Overlapping of MINK and CHRNE gene loci in the course of mammalian evolution. (PMID: 12087176) Dan I. … Kusumi A. (Nucleic Acids Res. 2002) 2 3
- The role of Misshapen NCK-related kinase (MINK), a novel Ste20 family kinase, in the IRES-mediated protein translation of human enterovirus 71. (PMID: 25747578) Leong S.Y. … Chu J.J. (PLoS Pathog. 2015) 3
Products for MINK1 Gene
- Browse R&D Systems for Antibodies
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- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for MINK1
- Search Origene for MassSpec and Protein Over-expression Lysates for MINK1
- Origene Custom Protein Services for MINK1
- Origene siRNA, shRNA, mouse_rna, and RNAi products in human, mouse, rat for MINK1
- Browse OriGene Inhibitory RNA Products For MINK1
- OriGene qPCR primer pairs for MINK1
- OriGene CRISPR knockouts for MINK1
- OriGene clones in human for MINK1
- OriGene ORF clones in human,mouse,rat for MINK1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- GenScript: Next-day shipping cDNA clones in your preferred vector
- GenScript Custom Purified and Recombinant Proteins Services for MINK1
- GenScript Custom Assay Services for MINK1
- GenScript Custom overexpressing Cell Line Services for MINK1
- GenScript: Design CRISPR guide RNA sequences for MINK1
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for MINK1
- Novus Biologicals Antibodies for MINK1
- Novus Biologicals proteins and lysates for MINK1
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Taconic Biosciences Mouse Models for MINK1
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Addgene plasmids for MINK1
- antibodies-online Antibodies for MINK1: See all 43
- antibodies-online Kits for MINK1: See all 4
- Search antibodies-online for proteins
- Search antibodies-online for peptides
- GeneTex MINK1 antibody for MINK1
- Search GeneTex for Proteins for MINK1
- ViGene Biosciences adenoviral particle packaged cDNA for MINK1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for MINK1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for MINK1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for MINK1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for MINK1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for MINK1 gene
- Search ViGene Biosciences for MINK1
- Search ViGene Biosciences for MINK1
- Santa Cruz Biotechnology (SCBT) Antibodies for MINK1
- Search Santa Cruz Biotechnology (SCBT) for MINK1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for MINK1
Sources for MINK1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) I2D
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
- (58) HUGE
- (59) IMGT
- (60) Leiden
- (61) MILLIPORE
- (62) miRBase
- (63) DME
- (64) Nature
- (65) NCBI
- (66) OriGene
- (67) PubMed
- (68) R&D Systems
- (69) Salk
- (70) TGDB
- (71) Tufts
- (72) YEDA
- (73) CROW21
- (74) Tocris
- (75) Abcam
- (76) Novus
- (77) ProSpec
- (78) Sino Biological
- (79) GenScript
- (80) Qiagen
- (81) Cloud-Clone Corp.
- (82) Enzo Life Sciences
- (83) OCA
- (84) Proteopedia
- (85) MOPED
- (86) SPIRE
- (87) neXtProt
- (88) Reactome
- (89) GeneGo (Thomson Reuters)
- (90) fRNAdb
- (91) DISEASES
- (92) SIMAP
- (93) GenomeRNAi
- (94) LifeMap
- (95) miRTarBase
- (96) MalaCards
- (97) Invitrogen
- (98) BitterDB
- (99) Vector BioLabs
- (100) ESI-BIO
- (101) RefSeq
- (102) BioSystems
- (103) MaxQB
- (104) IUPHAR
- (105) BioGPS
- (106) Illumina
- (107) COMPARTMENTS
- (108) HOMER
- (109) PaxDb
- (110) ApexBio
- (111) Addgene
- (112) Advanced Cell Diagnostics
- (113) antibodies-online
- (114) CYP
- (115) NONCODE
- (116) SwitchGear Genomics
- (117) TreeFam
- (118) PathCards
- (119) GeneReviews
- (120) GeneTex
- (121) Taconic Biosciences
- (122) GTEx
- (123) ProteomicsDB
- (124) SCBT
- (125) DGIdb
- (126) ClinicalTrials
- (127) FDA Approved Drugs
- (128) RVIS
- (129) SIGNOR
- (130) diseasecard
- (131) NIH Rare Diseases
- (132) Orphanet
- (133) UMLS
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- (135) Disease Ontology
- (136) Genetics Home Reference
- (137) MeSH
- (138) MedlinePlus
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- (141) NCBI Bookshelf
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- (144) ViGene Biosciences
- (145) HPO
- (146) UDN
- (147) VISTA
- (148) FANTOM5
- (149) ENCODE
- (150) ProSci
- (151) Horizon