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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MINK1 Gene

protein-coding   GIFtS: 61
GCID: GC17P004736

Misshapen-Like Kinase 1

(Previous name: misshapen-like kinase 1 (zebrafish))
  8 related diseases
at
MalaCards
 

Aliases
for MINK1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section
Aliases
Misshapen-Like Kinase 11 2     MAPK/ERK Kinase Kinase Kinase 62 3
Misshapen/NIK-Related Kinase1 2 3     MEK Kinase Kinase 62 3
MINK2 3 5     MEKKK 62 3
GCK Family Kinase MiNK2 3     EC 2.7.11.13 8
Mitogen-Activated Protein Kinase Kinase Kinase Kinase 62 3     Misshapen-Like Kinase 1 (Zebrafish)1
B552 3     hMINK2
MAP4K62 3     hMINKbeta2
YSK22 3     Serine/Threonine Protein Kinase2
ZC32 3     EC 2.7.118

External Ids:    HGNC: 175651   Entrez Gene: 504882   Ensembl: ENSG000001415037   OMIM: 6094265   UniProtKB: Q8N4C83   

Export aliases for MINK1 gene to outside databases

Previous GC identifer: GC17P004684


Summaries
for MINK1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for MINK1 Gene:
This gene encodes a serine/threonine kinase belonging to the germinal center kinase (GCK) family. The protein is
structurally similar to the kinases that are related to NIK and may belong to a distinct subfamily of NIK-related
kinases within the GCK family. Studies of the mouse homolog indicate an up-regulation of expression in the course of
postnatal mouse cerebral development and activation of the cJun N-terminal kinase (JNK) and the p38 pathways.
Alternative splicing occurs at this locus and four transcript variants encoding distinct isoforms have been
identified. (provided by RefSeq, Jul 2008)

GeneCards Summary for MINK1 Gene: 
MINK1 (misshapen-like kinase 1) is a protein-coding gene. Diseases associated with MINK1 include atrophic rhinitis, and balanitis, and among its related super-pathways are MAPK signaling pathway. GO annotations related to this gene include protein serine/threonine kinase activity and small GTPase regulator activity. An important paralog of this gene is TAOK2.

UniProtKB/Swiss-Prot: MINK1_HUMAN, Q8N4C8
Function: Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction
to control neuronal structure and AMPA receptor trafficking. Required for normal synaptic density, dendrite
complexity, as well as surface AMPA receptor expression in hippocampal neurons. Can activate the JNK and MAPK14/p38
pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK
pathway. Phosphorylates: TANC1 upon stimulation by RAP2A, MBP and SMAD1. Has an essential function in negative
selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1
Function: Isoform 4 can activate the JNK pathway. Involved in the regulation of actin cytoskeleton reorganization,
cell-matrix adhesion, cell-cell adhesion and cell migration

Gene Wiki entry for MINK1 Gene


Genomic Views
for MINK1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010718.16  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MINK1 gene promoter:
         AP-1   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MINK1 promoter sequence
   Search SABiosciences Chromatin IP Primers for MINK1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MINK1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.2   Ensembl cytogenetic band:  17p13.2   HGNC cytogenetic band: 17p13.2

MINK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MINK1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P004736:  view genomic region     (about GC identifiers)

Start:
 4,736,635 bp from pter      End:
 4,801,356 bp from pter
Size:
 64,722 bases      Orientation:
 plus strand

Proteins
for MINK1 gene

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section
UniProtKB/Swiss-Prot: MINK1_HUMAN, Q8N4C8 (See protein sequence)
Recommended Name: Misshapen-like kinase 1  
Size: 1332 amino acids; 149822 Da
Cofactor: Magnesium (By similarity)
Subunit: Interacts with TANC1 (By similarity). Interacts with RAP2A. Isoform 4 interacts with NCK1
Subcellular location: Cytoplasm. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density (By
similarity). Cell projection, axon (By similarity). Cell projection, dendrite (By similarity)
Subcellular location: Isoform 4: Golgi apparatus
Secondary accessions: D3DTK3 D3DTK4 Q5U8Z0 Q9P1X1 Q9P2R8
Alternative splicing: 5 isoforms:  Q8N4C8-1   Q8N4C8-2   Q8N4C8-3   Q8N4C8-4   Q8N4C8-5   

Explore the universe of human proteins at neXtProt for MINK1: NX_Q8N4C8

Explore proteomics data for MINK1 at MOPED 

Post-translational modifications:

  • UniProtKB: Autophosphorylated
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8N4C8

    • 4/32 DME Specific Peptides for MINK1 (Q8N4C8) (see all 32)
     PFIRDQP  WMAPEVI  RNDKVFF  MEFCGAGS 

    MINK1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MINK1 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001020108.1  NP_056531.1  NP_722549.2  NP_733763.1  

    ENSEMBL proteins: 
     ENSP00000347427   ENSP00000269296   ENSP00000461500   ENSP00000406487   ENSP00000459269  
     ENSP00000459699   ENSP00000459102  

    Human Recombinant Protein Products for MINK1: 
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    GenScript Purified and Recombinant Proteins for MINK1
    Novus Biologicals MINK1 Protein
    Novus Biologicals MINK1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MINK1 

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA18930710
    GO:0005794Golgi apparatus IDA15469942
    GO:0005886plasma membrane IEA--
    GO:0014069postsynaptic density IEA--
    GO:0030054cell junction IEA--

    MINK1 for ontologies           About GeneDecksing



    MINK1 Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for MINK1 

    Assay Products for MINK1: 
    Browse Kits and Assays available from EMD Millipore
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    GenScript MINK1-Activity-based Kinase Assay for Compound Screening
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    Cloud-Clone Corp. ELISAs for MINK1 
    Cloud-Clone Corp. CLIAs for MINK1

    Protein Domains /
    Families
    for MINK1 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    		 IUPHAR Guide to PHARMACOLOGY protein family classification: misshapen-like kinase 1 
    MSN subfamily

    5/6 InterPro protein domains (see all 6):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q8N4C8

    ProtoNet protein and cluster: Q8N4C8

    1 Blocks protein domain: IPB001180 Citron-like

    UniProtKB/Swiss-Prot: MINK1_HUMAN, Q8N4C8
    Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily
    Similarity: Contains 1 CNH domain
    Similarity: Contains 1 protein kinase domain


    MINK1 for domains           About GeneDecksing


    Function
    for MINK1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MINK1_HUMAN, Q8N4C8
    Function: Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction
    to control neuronal structure and AMPA receptor trafficking. Required for normal synaptic density, dendrite
    complexity, as well as surface AMPA receptor expression in hippocampal neurons. Can activate the JNK and MAPK14/p38
    pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK
    pathway. Phosphorylates: TANC1 upon stimulation by RAP2A, MBP and SMAD1. Has an essential function in negative
    selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1
    Function: Isoform 4 can activate the JNK pathway. Involved in the regulation of actin cytoskeleton reorganization,
    cell-matrix adhesion, cell-cell adhesion and cell migration
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Induction: Activated after Ras induction via a mechanism involving reactive oxygen species

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity TAS10708748
    GO:0004674protein serine/threonine kinase activity IDA18930710
    GO:0004713protein tyrosine kinase activity ----
    GO:0005083small GTPase regulator activity IEA--
    GO:0005515protein binding IPI15469942
         
    MINK1 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for MINK1:
     Decreased substrate adherent c  Increased cell death in HCC-19  Increased cell spreading 

         1 MGI phenotypic allele for Mink1 (no phenotypes)

    MINK1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for MINK1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MINK1

    miRNA
    Products:        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MINK1
    8/93 QIAGEN miScript miRNA Assays for microRNAs that regulate MINK1 (see all 93):
    hsa-miR-3938 hsa-miR-520e hsa-miR-520f hsa-miR-4254 hsa-miR-106a hsa-miR-15a hsa-miR-342-3p hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmid: MINK1 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MINK1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MINK1
    Sirion Biotech Custom design and validation of potent shRNA sequences against MINK1

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of MINK1
                         Customized adenovirus for potent knockdown of MINK1

    Clone
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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MINK1

    Cell Line
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                         Customized inducible knockdown cell line services for MINK1
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    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MINK1


    Pathways & Interactions
    for MINK1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MINK1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1MAPK signaling pathway
    		MAPK signaling pathway0.50
    2Insulin Signaling
    		Insulin Signaling


    2 BioSystems Pathways for MINK1
        MAPK signaling pathway
    Insulin Signaling


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MINK1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    5/18 Interacting proteins for MINK1 (Q8N4C83 ENSP000003474274) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CALM1P621583, ENSP000003494674I2D: score=1 STRING: ENSP00000349467
    CALM2P621583I2D: score=1 
    CALM3P621583I2D: score=1 
    ABI1Q8IZP03, ENSP000003653124I2D: score=2 STRING: ENSP00000365312
    YWHABP319463, ENSP000003001614I2D: score=2 STRING: ENSP00000300161
    About this table

    Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001952regulation of cell-matrix adhesion IMP15469942
    GO:0006468protein phosphorylation ISS--
    GO:0006950response to stress ISS--
    GO:0007243intracellular protein kinase cascade ISS--
    GO:0007254JNK cascade TAS10708748

    MINK1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for MINK1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, IUPHAR, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MINK1

    1 HMDB Compound for MINK1    About this table
    CompoundSynonyms CAS #PubMed Ids
    MagnesiumMagnesium (see all 2)7439-95-4--

    Search CenterWatch for drugs/clinical trials and news about MINK1

    Transcripts
    for MINK1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MINK1 gene (4 alternative transcripts): 
    NM_001024937.3  NM_015716.4  NM_153827.4  NM_170663.4  

    Unigene Cluster for MINK1:

    Misshapen-like kinase 1
    Hs.443417  [show with all ESTs]
    Unigene Representative Sequence: BC094686
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000355280(uc010vsl.2 uc010vsm.2 uc010vsn.2) ENST00000572330
    ENST00000347992(uc010vsk.2) ENST00000574453(uc010vso.2) ENST00000453408
    ENST00000577021 ENST00000571207(uc010vsp.2) ENST00000572629 ENST00000571526
    ENST00000572304 ENST00000574871 ENST00000575511 ENST00000576037
    miRNA
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    8/93 QIAGEN miScript miRNA Assays for microRNAs that regulate MINK1 (see all 93):
    hsa-miR-3938 hsa-miR-520e hsa-miR-520f hsa-miR-4254 hsa-miR-106a hsa-miR-15a hsa-miR-342-3p hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmid: MINK1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for MINK1
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    Clone
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    Primer
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    Additional mRNA sequence: 

    AB035698.1 AB041926.1 AF218033.1 AY775058.1 BC028888.1 BC034673.1 BC094686.1 

    17 DOTS entries:

    DT.450495  DT.101966234  DT.100794683  DT.95135307  DT.100794679  DT.100794681  DT.97859616  DT.100794680 
    DT.95084687  DT.102838682  DT.95135308  DT.92409449  DT.120991493  DT.120991431  DT.97859617  DT.121427451 
    DT.95332072 

    24/57 AceView cDNA sequences (see all 57):

    BM717445 BM718065 BF724524 AA366908 CA454128 BI908161 AL157418 BF868921 
    BM715816 AI125161 BM967105 BM701243 BG680567 CK823412 BG757547 BU838349 
    AK096610 AW802152 BM906355 AI087028 BE882515 BM796630 BI754257 CK823411 

    GeneLoc Exon Structure

    5/15 Alternative Splicing Database (ASD) splice patterns (SP) for MINK1 (see all 15)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b · 18c ^ 19a · 19b ^ 20a ·
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                      -                     
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 20b · 20c ^ 21 ^ 22a · 22b ^ 23 ^ 24a · 24b ^ 25 ^ 26a · 26b · 26c · 26d ^ 27 ^ 28a · 28b ^ 29a · 29b · 29c
    SP1:                    -                                                                                             
    SP2:                                                                                                                  
    SP3:                    -                                                                                             
    SP4:                    -                                                                                             
    SP5:                                                                                                                  


    ECgene alternative splicing isoforms for MINK1

    Expression
    for MINK1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MINK1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCTTCCCCG
    MINK1 Expression
    About this image


    See MINK1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MINK1

    SOURCE GeneReport for Unigene cluster: Hs.443417

    UniProtKB/Swiss-Prot: MINK1_HUMAN, Q8N4C8
    Tissue specificity: Expressed in the brain, isoform 2 is more abundant than isoform 1. Isoform 3 is ubiquitously
    expressed. Isoform 1 is most abundant in the skeletal muscle. Isoform 4 is ubiquitously expressed with relative high
    levels in brain, skeletal muscle, pancreas and testis

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    Orthologs
    for MINK1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for MINK1 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Mink11 , 5 misshapen-like kinase 1 (zebrafish)1, 5 91(n)1
    97.47(a)1    		   11 (43.00 cM)5
    509321  NM_176893.21  NP_795712.21 
     705628905 
    lizard
    (Anolis carolinensis)    		 Reptilia MINK16
    		 Uncharacterized protein
    		 75(a)
    		 1 ↔ 1
    		 GL344055.1(1901-57511)
    zebrafish
    (Danio rerio)    		 Actinopterygii mink16
    		 misshapen-like kinase 1
    		 75(a)
    		 1 ↔ 1
    		 5(39906030-39985212)
    fruit fly
    (Drosophila melanogaster)    		 Insecta msn6
    		 misshapen
    		 40(a)
    		 1 → many
    		 3L(2554847-2586540)
    worm
    (Caenorhabditis elegans)    		 Secernentea mig-151 Protein MIG-15 59(n)
    63.46(a)    		   181248  NM_001029802.2  NP_001024973.1 


    ENSEMBL Gene Tree for MINK1 (if available)
    TreeFam Gene Tree for MINK1 (if available)

    Paralogs
    for MINK1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MINK1 gene
    TAOK22  MAP4K52  TAOK32  NRK2  TNIK2  MAP4K22  MAP4K12  MAP4K32  
    MAP4K42  STK102  TAOK12  SLK2  
    18/41 SIMAP similar genes for MINK1 using alignment to 5 protein entries:     MINK1_HUMAN (see all proteins) (see all similar genes):
    MINK    MAP4K5    TNIK    MYO3A    PHKG2    MAP4K2
    MAP4K4    STK25    MYO3B    PAK2    STK3    TAOK3
    MST4    NEK9    STK24    STK4/SLC36AL fusion    PAK4    DKFZp686J1430

    MINK1 for paralogs           About GeneDecksing



    Genomic Variants
    for MINK1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1643 SNPs in MINK1 are shown (see all 1643)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 17 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    VAR_0460614
    		A gastric adenocarcinoma sample4--see VAR_0460612 E V mis40--------
    VAR_0408004
    		----see VAR_0408002 I V mis40--------
    rs1378810621,2
    		--4721497(+) AGGCCA/GAGGCA 4 -- us2k10--------
    rs797692611,2
    		C,F--4721591(+) CCAGGT/CGTAGT 4 -- us2k12Minor allele frequency- C:0.26NA EA 240
    rs1408399761,2
    		C--4721604(+) CATGCA/GCTGCC 4 -- us2k10--------
    rs1458568441,2
    		--4721606(+) TGCGCC/TGCCTG 4 -- us2k10--------
    rs1481673881,2
    		--4721647(+) GAGGAC/TAGCTT 4 -- us2k10--------
    rs1806886911,2
    		--4721809(+) CGGGCA/GGATCA 4 -- us2k10--------
    rs620736301,2
    		--4722065(+) ATTGAC/TTTGAA 4 -- us2k10--------
    rs1457599481,2
    		C--4722327(+) TGAGGA/GTCATA 4 -- us2k10--------

    HapMap Linkage Disequilibrium report for MINK1 (4736635 - 4801356 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/13 variations for MINK1 (see all 13):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2715558CNV Deletion23290073
    esv2715559CNV Deletion23290073
    nsv1953CNV Insertion18451855
    esv1005973CNV Insertion20482838
    esv1520671CNV Insertion17803354
    esv2537517CNV Insertion19546169
    nsv509647CNV Insertion20534489
    nsv907620CNV Loss21882294
    nsv833347CNV Loss17160897
    nsv833350CNV Loss17160897

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    Disorders / Diseases
    for MINK1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MINK1 for disorders           About GeneDecksing

    OMIM gene information: 609426    OMIM disorders: --

    8 diseases for MINK1:    About MalaCards
    atrophic rhinitis    balanitis    progressive supranuclear palsy    cerebritis
    long qt syndrome    rhinitis    choroiditis    neuronitis

    Genetic Association Database (GAD): MINK1
    Human Genome Epidemiology (HuGE) Navigator: MINK1 (3 documents)

    Export disorders for MINK1 gene to outside databases

    Publications
    for MINK1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MINK1 gene, integrated from 9 sources (see all 42):
    (articles sorted by number of sources associating them with MINK1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of MINK, a novel member of mammalian GCK family kinases, which is up-regulated during postnatal mouse cerebral development. (PubMed id 10708748)1, 2, 3 Dan I.... Kusumi A. (2000)
    2. Identification and functional characterization of a novel human misshapen/Nck interacting kinase-related kinase, hMINK beta. (PubMed id 15469942)1, 2, 9 Hu Y.... Xu X. (2004)
    3. MINK is a Rap2 effector for phosphorylation of the postsynaptic scaffold protein TANC1. (PubMed id 18930710)1, 2 Nonaka H....Kariya K. (2008)
    4. Molecular genetic analysis of long QT syndrome in Norway indicating a high prevalence of heterozygous mutation carriers. (PubMed id 18752142)1, 4 Berge K.E....Leren T.P. (2008)
    5. Analysis of minK and eNOS genes as candidate loci for predisposition to non-valvular atrial fibrillation. (PubMed id 16760206)1, 4 Fatini C....Gensini G.F. (2006)
    6. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    7. MinK gene polymorphism in the pathogenesis of lone atrial fibrillation. (PubMed id 17165161)1, 4 Prystupa A....Lorenc T. (2006)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. Overlapping of MINK and CHRNE gene loci in the course of mammalian evolution. (PubMed id 12087176)1, 3 Dan I.... Kusumi A. (2002)
    10. Computational and experimental studies on human misshapen/NIK-related kinase MINK-1. (PubMed id 15032605)1, 9 Qu K....Xu D. (2004)

    External Searches for MINK1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing MINK1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 50488 HGNC: 17565 AceView: MINK Ensembl:ENSG00000141503 euGenes: HUgn50488
    ECgene: MINK1 H-InvDB: MINK1

    Other Databases showing MINK1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing MINK1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MINK1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for MINK1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MINK1 gene:
    Search GeneIP for patents involving MINK1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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