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Aliases for MINK1 Gene

Aliases for MINK1 Gene

  • Misshapen-Like Kinase 1 2 3
  • Misshapen/NIK-Related Kinase 2 3 4
  • MINK 3 4 6
  • Mitogen-Activated Protein Kinase Kinase Kinase Kinase 6 3 4
  • MAPK/ERK Kinase Kinase Kinase 6 3 4
  • MEK Kinase Kinase 6 3 4
  • EC 2.7.11.1 4 63
  • MEKKK 6 3 4
  • MAP4K6 3 4
  • YSK2 3 4
  • B55 3 4
  • ZC3 3 4
  • Misshapen-Like Kinase 1 (Zebrafish) 2
  • Serine/Threonine Protein Kinase 3
  • GCK Family Kinase MINK 3
  • GCK Family Kinase MiNK 4
  • HMINKbeta 3
  • EC 2.7.11 63
  • HMINK 3

External Ids for MINK1 Gene

Previous GeneCards Identifiers for MINK1 Gene

  • GC17P004684
  • GC17P004736

Summaries for MINK1 Gene

Entrez Gene Summary for MINK1 Gene

  • This gene encodes a serine/threonine kinase belonging to the germinal center kinase (GCK) family. The protein is structurally similar to the kinases that are related to NIK and may belong to a distinct subfamily of NIK-related kinases within the GCK family. Studies of the mouse homolog indicate an up-regulation of expression in the course of postnatal mouse cerebral development and activation of the cJun N-terminal kinase (JNK) and the p38 pathways. Alternative splicing occurs at this locus and four transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for MINK1 Gene

MINK1 (Misshapen-Like Kinase 1) is a Protein Coding gene. Among its related pathways are MAPK signaling pathway and Cellular Senescence. GO annotations related to this gene include protein serine/threonine kinase activity. An important paralog of this gene is MAP4K3.

UniProtKB/Swiss-Prot for MINK1 Gene

  • Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking. Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons. Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates: TANC1 upon stimulation by RAP2A, MBP and SMAD1. Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1

  • Isoform 4 can activate the JNK pathway. Involved in the regulation of actin cytoskeleton reorganization, cell-matrix adhesion, cell-cell adhesion and cell migration

Gene Wiki entry for MINK1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MINK1 Gene

Genomics for MINK1 Gene

Regulatory Elements for MINK1 Gene

Transcription factor binding sites by QIAGEN in the MINK1 gene promoter:

Genomic Location for MINK1 Gene

Start:
4,833,340 bp from pter
End:
4,898,061 bp from pter
Size:
64,722 bases
Orientation:
Plus strand

Genomic View for MINK1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MINK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MINK1 Gene

Proteins for MINK1 Gene

  • Protein details for MINK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N4C8-MINK1_HUMAN
    Recommended name:
    Misshapen-like kinase 1
    Protein Accession:
    Q8N4C8
    Secondary Accessions:
    • D3DTK3
    • D3DTK4
    • Q5U8Z0
    • Q9P1X1
    • Q9P2R8

    Protein attributes for MINK1 Gene

    Size:
    1332 amino acids
    Molecular mass:
    149822 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interacts with TANC1 (By similarity). Interacts with RAP2A. Isoform 4 interacts with NCK1.

    Alternative splice isoforms for MINK1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MINK1 Gene

Proteomics data for MINK1 Gene at MOPED

Post-translational modifications for MINK1 Gene

Other Protein References for MINK1 Gene

Antibody Products

Domains for MINK1 Gene

Gene Families for MINK1 Gene

Suggested Antigen Peptide Sequences for MINK1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N4C8

UniProtKB/Swiss-Prot:

MINK1_HUMAN :
  • Q8N4C8
Domain:
  • Contains 1 CNH domain.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
genes like me logo Genes that share domains with MINK1: view

Function for MINK1 Gene

Molecular function for MINK1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot Function:
Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking. Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons. Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates: TANC1 upon stimulation by RAP2A, MBP and SMAD1. Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1
UniProtKB/Swiss-Prot Function:
Isoform 4 can activate the JNK pathway. Involved in the regulation of actin cytoskeleton reorganization, cell-matrix adhesion, cell-cell adhesion and cell migration
UniProtKB/Swiss-Prot Induction:
Activated after Ras induction via a mechanism involving reactive oxygen species.

Enzyme Numbers (IUBMB) for MINK1 Gene

Gene Ontology (GO) - Molecular Function for MINK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity TAS 10708748
GO:0004674 protein serine/threonine kinase activity IDA 18930710
GO:0004702 receptor signaling protein serine/threonine kinase activity IBA --
GO:0004713 protein tyrosine kinase activity --
GO:0005515 protein binding IPI 15469942
genes like me logo Genes that share ontologies with MINK1: view

Phenotypes for MINK1 Gene

genes like me logo Genes that share phenotypes with MINK1: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MINK1

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for MINK1 Gene

Localization for MINK1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MINK1 Gene

Cytoplasm. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell projection, axon. Cell projection, dendrite.
Isoform 4: Golgi apparatus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MINK1 Gene COMPARTMENTS Subcellular localization image for MINK1 gene
Compartment Confidence
golgi apparatus 5
nucleus 3
plasma membrane 3
cytoskeleton 2
cytosol 2

Gene Ontology (GO) - Cellular Components for MINK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 18930710
GO:0005794 Golgi apparatus IDA 15469942
GO:0005829 cytosol TAS --
GO:0014069 postsynaptic density IEA --
GO:0030054 cell junction IEA --
genes like me logo Genes that share ontologies with MINK1: view

Pathways for MINK1 Gene

genes like me logo Genes that share pathways with MINK1: view

Pathways by source for MINK1 Gene

Gene Ontology (GO) - Biological Process for MINK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001952 regulation of cell-matrix adhesion IMP 15469942
GO:0006468 protein phosphorylation ISS --
GO:0006950 response to stress ISS --
GO:0007254 JNK cascade TAS 10708748
GO:0007268 synaptic transmission ISS --
genes like me logo Genes that share ontologies with MINK1: view

Compounds for MINK1 Gene

(1) HMDB Compounds for MINK1 Gene

Compound Synonyms Cas Number PubMed IDs
Magnesium
  • Magnesium
7439-95-4
genes like me logo Genes that share compounds with MINK1: view

Transcripts for MINK1 Gene

Unigene Clusters for MINK1 Gene

Misshapen-like kinase 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MINK1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MINK1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b · 18c ^ 19a · 19b ^ 20a ·
SP1:
SP2:
SP3: -
SP4:
SP5:
SP6: - - - - - - - - - - - - - - - -
SP7:
SP8: - -
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

ExUns: 20b · 20c ^ 21 ^ 22a · 22b ^ 23 ^ 24a · 24b ^ 25 ^ 26a · 26b · 26c · 26d ^ 27 ^ 28a · 28b ^ 29a · 29b · 29c
SP1: -
SP2:
SP3: -
SP4: -
SP5:
SP6: - -
SP7:
SP8:
SP9: - -
SP10: -
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for MINK1 Gene

GeneLoc Exon Structure for
MINK1
ECgene alternative splicing isoforms for
MINK1

Expression for MINK1 Gene

mRNA expression in normal human tissues for MINK1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for MINK1 Gene

This gene is overexpressed in Brain (29.9), Heart (10.6), and Frontal cortex (6.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MINK1 Gene

SOURCE GeneReport for Unigene cluster for MINK1 Gene Hs.443417

mRNA Expression by UniProt/SwissProt for MINK1 Gene

Q8N4C8-MINK1_HUMAN
Tissue specificity: Expressed in the brain, isoform 2 is more abundant than isoform 1. Isoform 3 is ubiquitously expressed. Isoform 1 is most abundant in the skeletal muscle. Isoform 4 is ubiquitously expressed with relative high levels in brain, skeletal muscle, pancreas and testis.
genes like me logo Genes that share expressions with MINK1: view

Expression partners for MINK1 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for MINK1 Gene

Orthologs for MINK1 Gene

This gene was present in the common ancestor of animals.

Orthologs for MINK1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MINK1 35
  • 91.95 (n)
  • 97.48 (a)
MINK1 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MINK1 35
  • 89.81 (n)
  • 95.34 (a)
MINK 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mink1 35
  • 91.01 (n)
  • 97.45 (a)
Mink1 16
Mink1 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MINK1 35
  • 99.7 (n)
  • 99.77 (a)
MINK1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mink1 35
  • 90.46 (n)
  • 97.07 (a)
oppossum
(Monodelphis domestica)
Mammalia MINK1 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 48 (a)
ManyToMany
chicken
(Gallus gallus)
Aves NRK 36
  • 58 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia MINK1 36
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mink1 35
  • 77.1 (n)
  • 86.23 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.538 35
zebrafish
(Danio rerio)
Actinopterygii mink1 36
  • 76 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta msn 36
  • 43 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea mig-15 36
  • 51 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3520 36
  • 46 (a)
OneToMany
Species with no ortholog for MINK1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MINK1 Gene

ENSEMBL:
Gene Tree for MINK1 (if available)
TreeFam:
Gene Tree for MINK1 (if available)

Paralogs for MINK1 Gene

Paralogs for MINK1 Gene

genes like me logo Genes that share paralogs with MINK1: view

Variants for MINK1 Gene

Sequence variations from dbSNP and Humsavar for MINK1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs2246656 -- 4,891,197(+) ACACG(C/T)GCGCA intron-variant
rs2270158 -- 4,895,941(-) TCCCC(A/G)TGGTC intron-variant
rs2270159 -- 4,881,431(-) GAGTG(C/T)GGGGC intron-variant
rs2277681 -- 4,889,757(+) GAGCG(C/T)GAGCA reference, synonymous-codon
rs2277682 -- 4,890,072(+) TGTCA(C/T)CCCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MINK1 Gene

Variant ID Type Subtype PubMed ID
nsv833346 CNV Loss 17160897
nsv833347 CNV Loss 17160897
esv2537517 CNV Insertion 19546169
esv1520671 CNV Insertion 17803354
nsv833349 CNV Loss 17160897
esv2715558 CNV Deletion 23290073
nsv1953 CNV Insertion 18451855
nsv509647 CNV Insertion 20534489
nsv907619 CNV Loss 21882294
nsv907620 CNV Loss 21882294
esv1005973 CNV Insertion 20482838
esv2715559 CNV Deletion 23290073
nsv833350 CNV Loss 17160897

Relevant External Links for MINK1 Gene

HapMap Linkage Disequilibrium report
MINK1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MINK1 Gene

Disorders for MINK1 Gene

Relevant External Links for MINK1

Genetic Association Database (GAD)
MINK1
Human Genome Epidemiology (HuGE) Navigator
MINK1

No disorders were found for MINK1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for MINK1 Gene

Publications for MINK1 Gene

  1. Molecular cloning of MINK, a novel member of mammalian GCK family kinases, which is up-regulated during postnatal mouse cerebral development. (PMID: 10708748) Dan I. … Kusumi A. (FEBS Lett. 2000) 2 3 4
  2. Identification and functional characterization of a novel human misshapen/Nck interacting kinase-related kinase, hMINK beta. (PMID: 15469942) Hu Y. … Xu X. (J. Biol. Chem. 2004) 3 4 23
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Computational and experimental studies on human misshapen/NIK-related kinase MINK-1. (PMID: 15032605) Qu K. … Xu D. (Curr. Med. Chem. 2004) 3 23
  5. Overlapping of MINK and CHRNE gene loci in the course of mammalian evolution. (PMID: 12087176) Dan I. … Kusumi A. (Nucleic Acids Res. 2002) 2 3

Products for MINK1 Gene

  • Addgene plasmids for MINK1

Sources for MINK1 Gene

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