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Aliases for MINDY4B Gene

Aliases for MINDY4B Gene

  • MINDY Family Member 4B 2 3 5
  • Family With Sequence Similarity 188 Member B2 2 3
  • Protein FAM188B2 3 4
  • FAM188B2 3 4
  • C3orf76 3 4
  • Inactive Ubiquitin Carboxyl-Terminal Hydrolase MINDY-4B 3
  • Family With Sequence Similarity 188, Member B2 2
  • Chromosome 3 Open Reading Frame 76 2
  • Putative UPF0526 Protein B 3

External Ids for MINDY4B Gene

Previous HGNC Symbols for MINDY4B Gene

  • C3orf76
  • FAM188B2

Summaries for MINDY4B Gene

GeneCards Summary for MINDY4B Gene

MINDY4B (MINDY Family Member 4B) is a Protein Coding gene. An important paralog of this gene is MINDY4.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MINDY4B Gene

Genomics for MINDY4B Gene

Regulatory Elements for MINDY4B Gene

Enhancers for MINDY4B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G150724 1.6 FANTOM5 ENCODE dbSUPER 10.8 +177.8 177789 5.6 HDGF ATF1 PKNOX1 CREB3L1 ARNT TCF12 ZNF121 ELK1 GATA2 ZNF143 ERICH6-AS1 SIAH2 ERICH6 SIAH2-AS1 ENSG00000243273 MINDY4B SNRPCP3 LOC101928105
GH03G151145 1.3 Ensembl ENCODE dbSUPER 10.8 -240.8 -240768 1.7 RAD21 YY1 SCRT2 ZNF143 FOS DEK ZNF654 ZHX2 CEBPB GATAD2B MED12L P2RY14 MINDY4B ENSG00000243273 CLRN1 CLRN1-AS1 GC03M151148
GH03G150865 1.1 Ensembl ENCODE 12.3 +39.9 39939 0.6 ZSCAN4 ZBTB40 ZNF2 RAD21 RFX5 ZNF143 RELB PAF1 ZNF654 CEBPB ENSG00000243273 MINDY4B CLRN1 CLRN1-AS1
GH03G150925 1.2 FANTOM5 Ensembl ENCODE 11.2 -20.4 -20431 0.9 CTCF ZNF654 KLF1 PKNOX1 RNF2 REST RAD21 CBX8 GATA2 ZNF143 MINDY4B ENSG00000243273 CLRN1 CLRN1-AS1 MED12L P2RY14 ENSG00000260234
GH03G150869 0.8 Ensembl ENCODE 12.3 +34.8 34821 2.3 ZNF341 CEBPB FOS EZH2 ENSG00000243273 MINDY4B CLRN1 CLRN1-AS1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MINDY4B on UCSC Golden Path with GeneCards custom track

Genomic Location for MINDY4B Gene

150,871,045 bp from pter
150,905,439 bp from pter
34,395 bases
Minus strand

Genomic View for MINDY4B Gene

Genes around MINDY4B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MINDY4B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MINDY4B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MINDY4B Gene

Proteins for MINDY4B Gene

  • Protein details for MINDY4B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Inactive ubiquitin carboxyl-terminal hydrolase MINDY-4B
    Protein Accession:

    Protein attributes for MINDY4B Gene

    360 amino acids
    Molecular mass:
    41070 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MINDY4B Gene

Post-translational modifications for MINDY4B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MINDY4B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MINDY4B Gene

Domains & Families for MINDY4B Gene

Gene Families for MINDY4B Gene

Protein Domains for MINDY4B Gene


Suggested Antigen Peptide Sequences for MINDY4B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase MINDY family. FAM188 subfamily.
  • Belongs to the peptidase MINDY family. FAM188 subfamily.
genes like me logo Genes that share domains with MINDY4B: view

Function for MINDY4B Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MINDY4B Gene

Localization for MINDY4B Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MINDY4B gene
Compartment Confidence
mitochondrion 2
peroxisome 1
cytosol 1
golgi apparatus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for MINDY4B Gene

Pathways & Interactions for MINDY4B Gene

SuperPathways for MINDY4B Gene

No Data Available

Interacting Proteins for MINDY4B Gene

Gene Ontology (GO) - Biological Process for MINDY4B Gene


No data available for Pathways by source and SIGNOR curated interactions for MINDY4B Gene

Drugs & Compounds for MINDY4B Gene

No Compound Related Data Available

Transcripts for MINDY4B Gene

mRNA/cDNA for MINDY4B Gene

(3) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MINDY4B Gene

No ASD Table

Relevant External Links for MINDY4B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MINDY4B Gene

NURSA nuclear receptor signaling pathways regulating expression of MINDY4B Gene:

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MINDY4B Gene

Orthologs for MINDY4B Gene

This gene was present in the common ancestor of animals.

Orthologs for MINDY4B Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia FAM188B2 35
  • 83 (a)
(Bos Taurus)
Mammalia FAM188B2 35
  • 79 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 17 (a)
(Gallus gallus)
Aves FAM188B2 35
  • 64 (a)
(Anolis carolinensis)
Reptilia FAM188B2 35
  • 63 (a)
(Danio rerio)
Actinopterygii FAM188B2 35
  • 58 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG14142 35
  • 23 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 22 (a)
Species where no ortholog for MINDY4B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MINDY4B Gene

Gene Tree for MINDY4B (if available)
Gene Tree for MINDY4B (if available)

Paralogs for MINDY4B Gene

Paralogs for MINDY4B Gene

genes like me logo Genes that share paralogs with MINDY4B: view

Variants for MINDY4B Gene

Sequence variations from dbSNP and Humsavar for MINDY4B Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000057775 -- 150,888,054(+) GTGAG(A/C)CGAGA intron-variant
rs1000292313 -- 150,891,081(+) CTGCT(C/T)CTTCT reference, missense
rs1000379210 -- 150,879,635(+) GCCCT(C/T)GTTCA intron-variant
rs1000595479 -- 150,889,946(+) AATGG(C/T)CATTT intron-variant
rs1000749602 -- 150,884,515(+) TGTAT(A/T)TATTT intron-variant

Variation tolerance for MINDY4B Gene

Gene Damage Index Score: 1.70; 32.35% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MINDY4B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MINDY4B Gene

Disorders for MINDY4B Gene

Relevant External Links for MINDY4B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MINDY4B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MINDY4B Gene

Publications for MINDY4B Gene

  1. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny D.M. … Gibbs R.A. (Nature 2006) 3 4 64
  2. Alternative splice variants of the USH3A gene Clarin 1 (CLRN1). (PMID: 20717163) Vastinsalo H. … Sankila E.M. (Eur. J. Hum. Genet. 2011) 3 64
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 64

Products for MINDY4B Gene

Sources for MINDY4B Gene

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