Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MINDY1 Gene

Aliases for MINDY1 Gene

  • MINDY Lysine 48 Deubiquitinase 1 2 3 5
  • Motif Interacting With Ub-Containing Novel DUB 2 3
  • Family With Sequence Similarity 63 Member A 2 3
  • MIU-Containing Novel DUB Family Member 1 2 3
  • Deubiquitinating Enzyme MINDY-1 3 4
  • MINDY Deubiquitinase 1 2 3
  • Protein FAM63A 3 4
  • FAM63A 3 4
  • Ubiquitin Carboxyl-Terminal Hydrolase MINDY-1 3
  • Family With Sequence Similarity 63, Member A 2
  • EC 3.4.19.12 4
  • KIAA1390 4
  • MINDY-1 3

External Ids for MINDY1 Gene

Previous HGNC Symbols for MINDY1 Gene

  • FAM63A

Summaries for MINDY1 Gene

GeneCards Summary for MINDY1 Gene

MINDY1 (MINDY Lysine 48 Deubiquitinase 1) is a Protein Coding gene. An important paralog of this gene is MINDY2.

UniProtKB/Swiss-Prot for MINDY1 Gene

  • Hydrolase that can specifically remove Lys-48-linked conjugated ubiquitin from proteins. Has exodeubiquitinase activity and has a preference for long polyubiquitin chains. May play a regulatory role at the level of protein turnover.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MINDY1 Gene

Genomics for MINDY1 Gene

Regulatory Elements for MINDY1 Gene

Enhancers for MINDY1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G151308 2 FANTOM5 Ensembl ENCODE dbSUPER 10.8 -303.6 -303559 6.1 CREB3L1 AGO1 ZFP64 DMAP1 FEZF1 YY1 SLC30A9 ZNF143 ZNF263 SP3 MRPL9 GABPB2 SETDB1 GOLPH3L LYSMD1 PRPF3 UBE2D3P3 ZNF687 ADAMTSL4 RFX5
GH01G150925 1.1 ENCODE 10.6 +82.1 82099 2.4 HDGF PKNOX1 MLX CREB3L1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 HORMAD1 GABPB2 GOLPH3L UBE2D3P3 CTSK MRPL9 SF3B4 SETDB1 VPS45 PRPF3
GH01G151134 0.9 dbSUPER 11 -127.5 -127545 2.7 FOXA2 RAD21 ZNF48 RARA FOS ZNF362 CEBPB NFIL3 ZNF579 MIER3 BNIPL GABPB2 SEMA6C TNFAIP8L2 TMOD4 PRUNE1 MINDY1 SCNM1 LYSMD1 RNU6-884P
GH01G150969 1.8 FANTOM5 ENCODE dbSUPER 5.2 +33.4 33421 10.6 MLX ZFP64 DMAP1 YY1 ZNF143 SP3 SSRP1 GLIS1 RCOR2 NBN HORMAD1 ANXA9 GOLPH3L ARNT MCL1 CDC42SE1 ZNF687 CTSS MINDY1 LYSMD1
GH01G150484 0.9 Ensembl ENCODE 9.3 +523.5 523495 0.8 CTCF TAL1 REST RAD21 FOSL1 E2F1 ARID1B JUND SMARCA4 NCOR1 ECM1 ADAMTSL4 LOC100289061 ADAMTSL4-AS1 PRPF3 APH1A C1orf54 CA14 UBE2D3P3 CTSK
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MINDY1 on UCSC Golden Path with GeneCards custom track

Genomic Location for MINDY1 Gene

Chromosome:
1
Start:
150,996,086 bp from pter
End:
151,008,378 bp from pter
Size:
12,293 bases
Orientation:
Minus strand

Genomic View for MINDY1 Gene

Genes around MINDY1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MINDY1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MINDY1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MINDY1 Gene

Proteins for MINDY1 Gene

  • Protein details for MINDY1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N5J2-MINY1_HUMAN
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase MINDY-1
    Protein Accession:
    Q8N5J2
    Secondary Accessions:
    • B3KWP4
    • B3KWV8
    • B4DXF2
    • B4E1S4
    • D3DV09
    • J3KP53
    • Q5SZF0
    • Q9NUL9
    • Q9P2F7

    Protein attributes for MINDY1 Gene

    Size:
    469 amino acids
    Molecular mass:
    51778 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA92628.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MINDY1 Gene

    Alternative splice isoforms for MINDY1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MINDY1 Gene

Post-translational modifications for MINDY1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MINDY1 Gene

Domains & Families for MINDY1 Gene

Gene Families for MINDY1 Gene

Protein Domains for MINDY1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MINDY1 Gene

Graphical View of Domain Structure for InterPro Entry

Q8N5J2

UniProtKB/Swiss-Prot:

MINY1_HUMAN :
  • Belongs to the peptidase MINDY family. FAM63 subfamily.
Family:
  • Belongs to the peptidase MINDY family. FAM63 subfamily.
genes like me logo Genes that share domains with MINDY1: view

Function for MINDY1 Gene

Molecular function for MINDY1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
UniProtKB/Swiss-Prot Function:
Hydrolase that can specifically remove Lys-48-linked conjugated ubiquitin from proteins. Has exodeubiquitinase activity and has a preference for long polyubiquitin chains. May play a regulatory role at the level of protein turnover.

Enzyme Numbers (IUBMB) for MINDY1 Gene

Gene Ontology (GO) - Molecular Function for MINDY1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004843 thiol-dependent ubiquitin-specific protease activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0008233 peptidase activity IEA --
GO:0008234 cysteine-type peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with MINDY1: view
genes like me logo Genes that share phenotypes with MINDY1: view

Animal Models for MINDY1 Gene

MGI Knock Outs for MINDY1:

Animal Model Products

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MINDY1 Gene

Localization for MINDY1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MINDY1 gene
Compartment Confidence
extracellular 5
nucleus 2
peroxisome 1
cytosol 1

Gene Ontology (GO) - Cellular Components for MINDY1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with MINDY1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MINDY1 Gene

Pathways & Interactions for MINDY1 Gene

SuperPathways for MINDY1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MINDY1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0008150 biological_process ND --
GO:0071108 protein K48-linked deubiquitination IEA --
genes like me logo Genes that share ontologies with MINDY1: view

No data available for Pathways by source and SIGNOR curated interactions for MINDY1 Gene

Drugs & Compounds for MINDY1 Gene

No Compound Related Data Available

Transcripts for MINDY1 Gene

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for MINDY1 Gene

No ASD Table

Relevant External Links for MINDY1 Gene

GeneLoc Exon Structure for
MINDY1
ECgene alternative splicing isoforms for
MINDY1

Expression for MINDY1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of MINDY1 Gene:

MINDY1

Evidence on tissue expression from TISSUES for MINDY1 Gene

  • Nervous system(4.8)
  • Liver(4.1)
genes like me logo Genes that share expression patterns with MINDY1: view

Primer Products

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MINDY1 Gene

Orthologs for MINDY1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MINDY1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM63A 34 35
  • 99.42 (n)
dog
(Canis familiaris)
Mammalia FAM63A 34 35
  • 87.73 (n)
cow
(Bos Taurus)
Mammalia FAM63A 34 35
  • 85.65 (n)
mouse
(Mus musculus)
Mammalia Fam63a 34 16 35
  • 84.01 (n)
rat
(Rattus norvegicus)
Mammalia Fam63a 34
  • 83.65 (n)
oppossum
(Monodelphis domestica)
Mammalia FAM63A 35
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 42 (a)
ManyToMany
chicken
(Gallus gallus)
Aves LOC100859849 34
  • 73.25 (n)
FAM63A 35
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM63A 35
  • 47 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam63a 34
  • 69.21 (n)
zebrafish
(Danio rerio)
Actinopterygii fam63a 34 35
  • 66.07 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.877 34
worm
(Caenorhabditis elegans)
Secernentea Y55F3AM.9 35
  • 31 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 35
  • 25 (a)
ManyToMany
-- 35
  • 22 (a)
ManyToMany
-- 37
rice
(Oryza sativa)
Liliopsida Os.20605 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1538 35
  • 49 (a)
OneToMany
Species where no ortholog for MINDY1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MINDY1 Gene

ENSEMBL:
Gene Tree for MINDY1 (if available)
TreeFam:
Gene Tree for MINDY1 (if available)

Paralogs for MINDY1 Gene

Paralogs for MINDY1 Gene

genes like me logo Genes that share paralogs with MINDY1: view

Variants for MINDY1 Gene

Sequence variations from dbSNP and Humsavar for MINDY1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000195456 -- 150,998,226(+) ACTTG(C/T)TCCTC reference, synonymous-codon
rs1000283227 -- 151,005,157(+) TTGAA(C/G)AAAAG intron-variant
rs1000397284 -- 151,001,521(+) AAAGC(C/T)AAGGG intron-variant
rs1000499435 -- 150,996,792(+) GCCCA(C/T)CTTGG intron-variant, downstream-variant-500B, utr-variant-3-prime
rs1001007281 -- 151,003,622(+) CTAGG(A/C/T)TGGTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MINDY1 Gene

Variant ID Type Subtype PubMed ID
nsv1008496 CNV gain 25217958
nsv522317 CNV loss 19592680
nsv522840 CNV gain 19592680

Variation tolerance for MINDY1 Gene

Residual Variation Intolerance Score: 72.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.68; 57.15% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MINDY1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MINDY1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MINDY1 Gene

Disorders for MINDY1 Gene

Relevant External Links for MINDY1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MINDY1

No disorders were found for MINDY1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MINDY1 Gene

Publications for MINDY1 Gene

  1. MINDY-1 is a member of an evolutionarily conserved and structurally distinct new family of deubiquitinating enzymes. (PMID: 27292798) Abdul Rehman S.A. … Kulathu Y. (Mol. Cell 2016) 2 3 4 64
  2. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4 64
  3. A single MIU motif of MINDY-1 recognizes K48-linked polyubiquitin chains. (PMID: 28082312) Kristariyanto Y.A. … Kulathu Y. (EMBO Rep. 2017) 3 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for MINDY1 Gene

Sources for MINDY1 Gene

Content
Loading form....