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Aliases for MINDY1 Gene

Aliases for MINDY1 Gene

  • MINDY Lysine 48 Deubiquitinase 1 2 3 5
  • Motif Interacting With Ub-Containing Novel DUB 2 3
  • Family With Sequence Similarity 63 Member A 2 3
  • MIU-Containing Novel DUB Family Member 1 2 3
  • Deubiquitinating Enzyme MINDY-1 3 4
  • MINDY Deubiquitinase 1 2 3
  • Protein FAM63A 3 4
  • FAM63A 3 4
  • Ubiquitin Carboxyl-Terminal Hydrolase MINDY-1 3
  • Family With Sequence Similarity 63, Member A 2
  • EC 3.4.19.12 4
  • KIAA1390 4
  • MINDY-1 3

External Ids for MINDY1 Gene

Previous HGNC Symbols for MINDY1 Gene

  • FAM63A

Summaries for MINDY1 Gene

GeneCards Summary for MINDY1 Gene

MINDY1 (MINDY Lysine 48 Deubiquitinase 1) is a Protein Coding gene. An important paralog of this gene is MINDY2.

UniProtKB/Swiss-Prot for MINDY1 Gene

  • Hydrolase that can specifically remove Lys-48-linked conjugated ubiquitin from proteins. Has exodeubiquitinase activity and has a preference for long polyubiquitin chains. May play a regulatory role at the level of protein turnover.

Additional gene information for MINDY1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MINDY1 Gene

Genomics for MINDY1 Gene

Regulatory Elements for MINDY1 Gene

Enhancers for MINDY1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H151308 2 FANTOM5 Ensembl ENCODE dbSUPER 10.8 -303.6 -303559 6 PKNOX1 FOXA2 ARNT ARID4B SIN3A YY1 ZNF766 FOS DEK SP3 PIP5K1A PRPF3 GABPB2 PI4KB MRPL9 ZNF687 RFX5 LOC100507670 SETDB1 POGZ
GH01H150925 1.1 ENCODE 10.6 +82.1 82099 2 HDGF PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 HORMAD1 GABPB2 POGZ PI4KB PRPF3 UBE2D3P3 CTSK SF3B4 RPRD2 SETDB1
GH01H150969 1.8 FANTOM5 ENCODE dbSUPER 5.2 +33.4 33421 10 MLX ZFP64 DMAP1 YY1 ZNF143 SP3 ZC3H11A SSRP1 GLIS1 RCOR2 HORMAD1 SETDB1 ZNF687 PRPF3 PIP5K1A ARNT GOLPH3L PI4KB UBE2D3P3 GABPB2
GH01H150484 0.9 Ensembl ENCODE 9.4 +523.5 523495 0 CTCF TAL1 REST RAD21 FOSL1 E2F1 CC2D1A SMARCA4 NCOR1 SMC3 ECM1 ADAMTSL4 LOC100289061 ADAMTSL4-AS1 PRPF3 APH1A C1orf54 CA14 UBE2D3P3 CTSK
GH01H151099 0.7 ENCODE 10.9 -91.6 -91602 0 CTCF ZNF654 TRIM22 ZNF384 REST NFXL1 RAD21 RFX5 ZNF664 TARDBP TNFAIP8L2 SEMA6C GABPB2 PRUNE1 MINDY1 TMOD4 SCNM1 LYSMD1 VPS72 PIP5K1A
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MINDY1 on UCSC Golden Path with GeneCards custom track

Genomic Location for MINDY1 Gene

Chromosome:
1
Start:
150,996,086 bp from pter
End:
151,008,378 bp from pter
Size:
12,293 bases
Orientation:
Minus strand

Genomic View for MINDY1 Gene

Genes around MINDY1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MINDY1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MINDY1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MINDY1 Gene

Proteins for MINDY1 Gene

  • Protein details for MINDY1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N5J2-MINY1_HUMAN
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase MINDY-1
    Protein Accession:
    Q8N5J2
    Secondary Accessions:
    • B3KWP4
    • B3KWV8
    • B4DXF2
    • B4E1S4
    • D3DV09
    • J3KP53
    • Q5SZF0
    • Q9NUL9
    • Q9P2F7

    Protein attributes for MINDY1 Gene

    Size:
    469 amino acids
    Molecular mass:
    51778 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA92628.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MINDY1 Gene

    Alternative splice isoforms for MINDY1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MINDY1 Gene

Post-translational modifications for MINDY1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MINDY1 Gene

Domains & Families for MINDY1 Gene

Gene Families for MINDY1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MINDY1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MINDY1 Gene

Graphical View of Domain Structure for InterPro Entry

Q8N5J2

UniProtKB/Swiss-Prot:

MINY1_HUMAN :
  • Belongs to the peptidase MINDY family. FAM63 subfamily.
Family:
  • Belongs to the peptidase MINDY family. FAM63 subfamily.
genes like me logo Genes that share domains with MINDY1: view

Function for MINDY1 Gene

Molecular function for MINDY1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
UniProtKB/Swiss-Prot Function:
Hydrolase that can specifically remove Lys-48-linked conjugated ubiquitin from proteins. Has exodeubiquitinase activity and has a preference for long polyubiquitin chains. May play a regulatory role at the level of protein turnover.

Enzyme Numbers (IUBMB) for MINDY1 Gene

Phenotypes From GWAS Catalog for MINDY1 Gene

Gene Ontology (GO) - Molecular Function for MINDY1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004843 thiol-dependent ubiquitin-specific protease activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0008233 peptidase activity IEA --
GO:0008234 cysteine-type peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with MINDY1: view
genes like me logo Genes that share phenotypes with MINDY1: view

Animal Models for MINDY1 Gene

MGI Knock Outs for MINDY1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for MINDY1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MINDY1 Gene

Localization for MINDY1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MINDY1 gene
Compartment Confidence
extracellular 5
nucleus 2
peroxisome 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MINDY1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with MINDY1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MINDY1 Gene

Pathways & Interactions for MINDY1 Gene

SuperPathways for MINDY1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MINDY1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0008150 biological_process ND --
GO:0071108 protein K48-linked deubiquitination IEA --
genes like me logo Genes that share ontologies with MINDY1: view

No data available for Pathways by source and SIGNOR curated interactions for MINDY1 Gene

Drugs & Compounds for MINDY1 Gene

No Compound Related Data Available

Transcripts for MINDY1 Gene

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for MINDY1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MINDY1 Gene

No ASD Table

Relevant External Links for MINDY1 Gene

GeneLoc Exon Structure for
MINDY1
ECgene alternative splicing isoforms for
MINDY1

Expression for MINDY1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of MINDY1 Gene:

MINDY1

Evidence on tissue expression from TISSUES for MINDY1 Gene

  • Nervous system(4.8)
  • Liver(4.1)
genes like me logo Genes that share expression patterns with MINDY1: view

Primer Products

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MINDY1 Gene

Orthologs for MINDY1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MINDY1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM63A 33 34
  • 99.42 (n)
dog
(Canis familiaris)
Mammalia FAM63A 34 33
  • 87.73 (n)
OneToOne
cow
(Bos Taurus)
Mammalia FAM63A 34 33
  • 85.65 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Fam63a 34 33
  • 84.01 (n)
OneToOne
Mindy1 16
rat
(Rattus norvegicus)
Mammalia Fam63a 33
  • 83.65 (n)
oppossum
(Monodelphis domestica)
Mammalia FAM63A 34
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 42 (a)
ManyToMany
chicken
(Gallus gallus)
Aves LOC100859849 33
  • 73.25 (n)
FAM63A 34
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM63A 34
  • 47 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam63a 33
  • 69.21 (n)
zebrafish
(Danio rerio)
Actinopterygii fam63a 33 34
  • 66.07 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.877 33
worm
(Caenorhabditis elegans)
Secernentea Y55F3AM.9 34
  • 31 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 34
  • 25 (a)
ManyToMany
-- 34
  • 22 (a)
ManyToMany
-- 36
rice
(Oryza sativa)
Liliopsida Os.20605 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1538 34
  • 49 (a)
OneToMany
Species where no ortholog for MINDY1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MINDY1 Gene

ENSEMBL:
Gene Tree for MINDY1 (if available)
TreeFam:
Gene Tree for MINDY1 (if available)

Paralogs for MINDY1 Gene

Paralogs for MINDY1 Gene

genes like me logo Genes that share paralogs with MINDY1: view

Variants for MINDY1 Gene

Sequence variations from dbSNP and Humsavar for MINDY1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000195456 -- 150,998,226(+) ACTTG(C/T)TCCTC reference, synonymous-codon
rs1000283227 -- 151,005,157(+) TTGAA(C/G)AAAAG intron-variant
rs1000397284 -- 151,001,521(+) AAAGC(C/T)AAGGG intron-variant
rs1000499435 -- 150,996,792(+) GCCCA(C/T)CTTGG intron-variant, downstream-variant-500B, utr-variant-3-prime
rs1001007281 -- 151,003,622(+) CTAGG(A/C/T)TGGTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MINDY1 Gene

Variant ID Type Subtype PubMed ID
nsv1008496 CNV gain 25217958
nsv522317 CNV loss 19592680
nsv522840 CNV gain 19592680

Variation tolerance for MINDY1 Gene

Residual Variation Intolerance Score: 72.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.68; 57.15% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MINDY1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MINDY1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MINDY1 Gene

Disorders for MINDY1 Gene

Relevant External Links for MINDY1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MINDY1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MINDY1

No disorders were found for MINDY1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MINDY1 Gene

Publications for MINDY1 Gene

  1. MINDY-1 Is a Member of an Evolutionarily Conserved and Structurally Distinct New Family of Deubiquitinating Enzymes. (PMID: 27292798) Abdul Rehman SA … Kulathu Y (Molecular cell 2016) 2 3 4 60
  2. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3 4 60
  3. A single MIU motif of MINDY-1 recognizes K48-linked polyubiquitin chains. (PMID: 28082312) Kristariyanto YA … Kulathu Y (EMBO reports 2017) 3 4 60
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60

Products for MINDY1 Gene

Sources for MINDY1 Gene

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