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MINA Gene

protein-coding   GIFtS: 58
GCID: GC03M097660

MYC Induced Nuclear Antigen

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
MYC Induced Nuclear Antigen1 2     NO522 3
MDIG2 3 5     ROX2 3
MINA532 3 5     Bifunctional Lysine-Specific Demethylase And Histidyl-Hydroxylase MINA2
Histone Lysine Demethylase MINA2 3     Mineral Dust Induced Gene Protein2
Mineral Dust-Induced Gene Protein2 3     Myc-Induced Nuclear Antigen, 53 KDa2
Nucleolar Protein 522 3     EC 1.14.11.-3
Ribosomal Oxygenase MINA2 3     MYC-Induced Nuclear Antigen3
60S Ribosomal Protein L27a Histidine Hydroxylase2 3     

External Ids:    HGNC: 194411   Entrez Gene: 848642   Ensembl: ENSG000001708547   OMIM: 6120495   UniProtKB: Q8IUF83   

Export aliases for MINA gene to outside databases

Previous GC identifers: GC03M098985 GC03M099146 GC03M095030


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MINA Gene:
MINA is a c-Myc (MYC; MIM 190080) target gene that may play a role in cell proliferation or regulation of cell
growth. (Tsuneoka et al., 2002 (PubMed 12091391); Zhang et al., 2005 (PubMed 15897898)).(supplied by OMIM, May
2008)

GeneCards Summary for MINA Gene:
MINA (MYC induced nuclear antigen) is a protein-coding gene. Diseases associated with MINA include esophageal squamous cell carcinoma, and gingivitis. GO annotations related to this gene include RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription and dioxygenase activity.

UniProtKB/Swiss-Prot: MINA_HUMAN, Q8IUF8
Function: Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Is
involved in the demethylation of trimethylated 'Lys-9' on histone H3 (H3K9me3), leading to an increase in
ribosomal RNA expression. Also catalyzes the hydroxylation of 60S ribosomal protein L27a on 'His-39'. May play an
important role in cell growth and survival. May be involved in ribosome biogenesis, most likely during the
assembly process of pre-ribosomal particles

Gene Wiki entry for MINA Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NT_005612.17  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MINA gene promoter:
         RORalpha1   S8   FOXO3   HNF-3beta   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMINA promoter sequence
   Search Chromatin IP Primers for MINA

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MINA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q11.2   Ensembl cytogenetic band:  3q11.2   HGNC cytogenetic band: 3q22.1

MINA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MINA gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M097660:  view genomic region     (about GC identifiers)

Start:
97,660,661 bp from pter      End:
97,691,301 bp from pter
Size:
30,641 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MINA_HUMAN, Q8IUF8 (See protein sequence)
Recommended Name: Bifunctional lysine-specific demethylase and histidyl-hydroxylase MINA  
Size: 465 amino acids; 52800 Da
Cofactor: Binds 1 Fe(2+) ion per subunit (By similarity)
Sequence caution: Sequence=CAH10679.1; Type=Erroneous termination; Positions=431; Note=Translated as Trp;
1 PDB 3D structure from and Proteopedia for MINA:
2XDV (3D)    
Secondary accessions: D3DN35 Q6AHW4 Q6SKS0 Q8IU69 Q8IUF6 Q8IUF7 Q96C17 Q96KB0
Alternative splicing: 4 isoforms:  Q8IUF8-1   Q8IUF8-2   Q8IUF8-3   Q8IUF8-4   

Explore the universe of human proteins at neXtProt for MINA: NX_Q8IUF8

Explore proteomics data for MINA at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MINA Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001035998.1  NP_001248758.1  NP_116167.3  NP_694822.2  

    ENSEMBL proteins: 
     ENSP00000328251   ENSP00000377748   ENSP00000353395   ENSP00000421347   ENSP00000424955  
     ENSP00000424530   ENSP00000423816   ENSP00000327424  

    MINA Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Purified Protein for MINA
    OriGene Protein Over-expression Lysate for MINA
    OriGene MassSpec for MINA
    OriGene Custom Protein Services for MINA
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    Novus Biologicals MINA Protein
    Novus Biologicals MINA Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MINA

    MINA Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Novus Biologicals MINA Antibodies
    Abcam antibodies for MINA
    Cloud-Clone Corp. Antibodies for MINA
    ThermoFisher Antibody for MINA
    LSBio Antibodies in human, mouse, rat for MINA

    MINA Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for MINA
    Browse Enzo Life Sciences for kits & assays
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    Cloud-Clone Corp. CLIAs for MINA


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR013109 NO66/MINA
     IPR003347 JmjC_dom

    Graphical View of Domain Structure for InterPro Entry Q8IUF8

    ProtoNet protein and cluster: Q8IUF8

    2 Blocks protein domains:
    IPB003347 Transcription factor jumonji
    IPB013109 Cupin 4


    UniProtKB/Swiss-Prot: MINA_HUMAN, Q8IUF8
    Similarity: Belongs to the MINA53/NO66 family
    Similarity: Contains 1 JmjC domain


    MINA for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MINA_HUMAN, Q8IUF8
    Function: Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Is
    involved in the demethylation of trimethylated 'Lys-9' on histone H3 (H3K9me3), leading to an increase in
    ribosomal RNA expression. Also catalyzes the hydroxylation of 60S ribosomal protein L27a on 'His-39'. May play an
    important role in cell growth and survival. May be involved in ribosome biogenesis, most likely during the
    assembly process of pre-ribosomal particles
    Catalytic activity: L-histidine-[60S ribosomal protein L27a] + 2-oxoglutarate + O(2) =
    (3S)-3-hydroxy-L-histidine-[60S ribosomal protein L27a] + succinate + CO(2)
    Induction: Up-regulated in response to MYC, in alveolar macrophages from coal miners and in silica
    particle-treated A549 lung cancer cells

         Enzyme Number (IUBMB): EC 1.14.11.-1

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001191RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription IEA--
    GO:0005515protein binding ----
    GO:0046872metal ion binding IEA--
    GO:0051213dioxygenase activity IEA--
         
    MINA for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for MINA:
     Decreased number of cells in m 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Mina):
     hematopoietic system  homeostasis/metabolism  immune system  respiratory system 

    MINA for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Minatm1Mtsun for MINA

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MINA
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MINA

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MINA
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MINA

    miRNA
    Products:
        
    miRTarBase miRNAs that target MINA:
    hsa-mir-92a-3p (MIRT049594), hsa-mir-7-5p (MIRT025908), hsa-mir-16-5p (MIRT031956), hsa-mir-124-3p (MIRT023061)

    Block miRNA regulation of human, mouse, rat MINA using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MINA (see all 45):
    hsa-miR-562 hsa-miR-4254 hsa-miR-607 hsa-miR-1245 hsa-miR-1258 hsa-miR-548m hsa-miR-298 hsa-miR-654-5p
    SwitchGear 3'UTR luciferase reporter plasmidMINA 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MINA
    Predesigned siRNA for gene silencing in human, mouse, rat MINA

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MINA

    Clone
    Products:
         
    OriGene clones in human, mouse for MINA (see all 20)
    OriGene ORF clones in mouse, rat for MINA
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): MINA (NM_001042533)
    Sino Biological Human cDNA Clone for MINA
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MINA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MINA

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MINA
    Browse ESI BIO Cell Lines and PureStem Progenitors for MINA 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MINA


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MINA_HUMAN, Q8IUF8: Nucleus. Nucleus, nucleolus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005667transcription factor complex IEA--
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol IEA--

    MINA for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MINA About    
    See pathways by source

    SuperPathContained pathways About
    1Validated targets of C-MYC transcriptional activation
    Validated targets of C-MYC transcriptional activation


    1 BioSystems Pathway for MINA
        Validated targets of C-MYC transcriptional activation



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MINA
    Interactions:

        GeneGlobe Interaction Network for MINA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for MINA (Q8IUF82, 3 ENSP000003282514) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MYCP011063, ENSP000003672074I2D: score=2 STRING: ENSP00000367207
    MYBBP1AQ9BQG03, ENSP000003709684I2D: score=1 STRING: ENSP00000370968
    PRKAA1Q131313I2D: score=1 
    MINAQ8IUF82MINT-68176
    MAXENSP000003514904STRING: ENSP00000351490
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter ----
    GO:0042254ribosome biogenesis IEA--

    MINA for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MINA



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MINA gene (4 alternative transcripts): 
    NM_001042533.2  NM_001261829.1  NM_032778.5  NM_153182.3  

    Unigene Cluster for MINA:

    MYC induced nuclear antigen
    Hs.570562  [show with all ESTs]
    Unigene Representative Sequence: NM_001042533
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000333396(uc003dsa.1 uc003drz.1 uc003dsb.1 uc003dsc.1)
    ENST00000394198 ENST00000506682 ENST00000360258 ENST00000503517 ENST00000503097
    ENST00000514314(uc010hpa.1) ENST00000507612 ENST00000506099 ENST00000330299(uc010hpb.1)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MINA using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MINA (see all 45):
    hsa-miR-562 hsa-miR-4254 hsa-miR-607 hsa-miR-1245 hsa-miR-1258 hsa-miR-548m hsa-miR-298 hsa-miR-654-5p
    SwitchGear 3'UTR luciferase reporter plasmidMINA 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MINA
    Predesigned siRNA for gene silencing in human, mouse, rat MINA
    Clone
    Products:
         
    OriGene clones in human, mouse for MINA (see all 20)
    OriGene ORF clones in mouse, rat for MINA
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): MINA (NM_001042533)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MINA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MINA
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for MINA
    OriGene qSTAR qPCR primer pairs in human, mouse for MINA
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MINA
      QuantiTect SYBR Green Assays in human, mouse, rat MINA
      QuantiFast Probe-based Assays in human, mouse, rat MINA

    Additional mRNA sequence: 

    AB083189.1 AB083190.1 AB083192.1 AB083193.1 AK027299.1 AY302110.3 AY390536.1 BC014928.1 
    CR627479.1 DQ453796.1 

    11 DOTS entries:

    DT.101977824  DT.95268418  DT.95356072  DT.100027234  DT.99944672  DT.95148055  DT.40203063  DT.100027233 
    DT.120924275  DT.97764336  DT.100027235 

    Selected AceView cDNA sequences (see all 135):

    AA602595 BX093929 AB083192 AY302110 BE463617 BQ002687 AA464689 BQ001416 
    AA866035 BU676897 AI271552 BX384540 CR604605 BM129584 Z28710 AW263409 
    AY456380 BQ017091 BX360674 AI961917 AI696914 BI758152 AI720443 BI858882 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MINA (see all 9)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b
    SP1:                                                                          -     -                                         -               
    SP2:                                                                          -                                                               
    SP3:                                                                          -     -                                                         
    SP4:                                                                                                                          -               
    SP5:        -     -                                                                                                                           


    ECgene alternative splicing isoforms for MINA

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MINA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAGAAAGAA
    MINA Expression
    About this image


    MINA expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    MINA Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MINA Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.570562

    UniProtKB/Swiss-Prot: MINA_HUMAN, Q8IUF8
    Tissue specificity: Expressed in liver, skeletal muscle, heart, pancreas, and placenta. Not detected in brain,
    lung or kidney. Expressed in several lung cancer tissues, but is barely detected in the adjacent non-cancerous
    tissues. Also highly expressed in several esophageal squamous cell carcinoma (ESCC), and colon cancer tissues,
    and in various cancer cell lines

        Custom PCR Arrays for MINA
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for MINA
    OriGene qSTAR qPCR primer pairs in human, mouse for MINA
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MINA
    QuantiTect SYBR Green Assays in human, mouse, rat MINA
    QuantiFast Probe-based Assays in human, mouse, rat MINA
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MINA

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MINA gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mina1 , 5 myc induced nuclear antigen1, 5 80.93(n)1
    76.56(a)1
      16 (34.83 cM)5
    670141  NM_025910.31  NP_080186.31 
     594717755 
    chicken
    (Gallus gallus)
    Aves MINA1 MYC induced nuclear antigen 70.78(n)
    71.86(a)
      418436  NM_001079723.1  NP_001073191.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    64(a)
    64(a)
    many → 1
    many → 1
    3(164055169-164070151)
    2(118718177-118719168)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.148932 Xenopus laevis transcribed sequence with weak similarity more 75.77(n)    BX848254.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc638732 hypothetical protein MGC63873 78.8(n)   393308  BC053125.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG29826
    --
    18(a)
    1 ↔ 1
    X(4213473-4215778)
    worm
    (Caenorhabditis elegans)
    Secernentea jmjc-16
    Protein JMJC-1, isoform a
    17(a)
    1 ↔ 1
    I(3631090-3636485) WBGene00020902


    ENSEMBL Gene Tree for MINA (if available)
    TreeFam Gene Tree for MINA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MINA gene
    1 SIMAP similar gene for MINA using alignment to 4 protein entries:     MINA_HUMAN (see all proteins):
    NO66

    MINA for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for MINA
    PGOHUM00000248224


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MINA (see all 564)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2002480681,2
    C--97664611(+) TCACAA/C/GGATAG 4 -- int10--------
    rs21722571,2,,4
    C,F,A,H--97664725(+) TTGAGC/TTTCAT 8 T A mis133Minor allele frequency- T:0.49EA NA NS WA CSA EU 10349
    rs1997696301,2
    --97664752(+) AAATGC/TATTAG 4 -- int10--------
    rs1387926301,2
    --97664897(+) GTGACA/GGGTGT 4 -- int10--------
    rs1414181701,2
    --97665014(+) AAGAGC/TATCTT 4 -- int10--------
    rs588715511,2
    C,F--97665162(+) GAAGTC/AATTAA 4 -- int11Minor allele frequency- A:0.09EA 120
    rs1146507541,2
    F--97665324(+) AGATAA/TGGGCA 4 -- int11Minor allele frequency- T:0.01WA 118
    rs2011632241,2
    --97665420(+) TGTAC-/TTTTGA 4 -- int10--------
    rs1432454081,2
    C--97665430(+) GGATG-/TATA  
            
    TATAT
    4 -- int10--------
    rs676240661,2
    C--97665431(+) TATAT-/ATAT/ATATATAT
    CTAT
    /TATA/TATATA
    CTATT
    12 -- int1 cds10--------

    HapMap Linkage Disequilibrium report for MINA (97660661 - 97691301 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for MINA:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv520553CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MINA
    DNA2.0 Custom Variant and Variant Library Synthesis for MINA

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612049    OMIM disorders: --

    7 diseases for MINA:    
    About MalaCards
    esophageal squamous cell carcinoma    gingivitis    lung cancer    renal cell carcinoma
    esophagitis    squamous cell carcinoma    asthma


    MINA for disorders           About GeneDecksing


    Export disorders for MINA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MINA gene, integrated from 10 sources (see all 35):
    (articles sorted by number of sources associating them with MINA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel myc target gene, mina53, that is involved in cell proliferation. (PubMed id 12091391)1, 2, 3, 9 Tsuneoka M.... Kimura H. (J. Biol. Chem. 2002)
    2. Lung cancer-associated JmjC domain protein mdig suppresses formation of tri-methyl lysine 9 of histone H3. (PubMed id 19502796)1, 2 Lu Y.... Chen F. (Cell Cycle 2009)
    3. The human mineral dust-induced gene, mdig, is a cell growth regulating gene associated with lung cancer. (PubMed id 15897898)1, 2 Zhang Y.... Chen F. (Oncogene 2005)
    4. Protein NO52 -- a constitutive nucleolar component sharing high sequence homologies to protein NO66. (PubMed id 15819408)1, 2 Eilbracht J.... Schmidt-Zachmann M.S. (Eur. J. Cell Biol. 2005)
    5. Mina53 as a potential prognostic factor for esophageal squamous cell carcinoma. (PubMed id 15534111)1, 2 Tsuneoka M.... Kimura H. (Clin. Cancer Res. 2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. NO66, a highly conserved dual location protein in the nucleolus and in a special type of synchronously replicating chromatin. (PubMed id 14742713)1, 2 Eilbracht J.... Schmidt-Zachmann M.S. (Mol. Biol. Cell 2004)
    8. Increased expression of a Myc target gene Mina53 in human colon cancer. (PubMed id 14695334)1, 2 Teye K.... Kimura H. (Am. J. Pathol. 2004)
    9. Increased expression of mdig predicts poorer survival of the breast cancer patients. (PubMed id 24309373)1 Thakur C....Chen F. (Gene 2014)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84864 HGNC: 19441 AceView: MINA Ensembl:ENSG00000170854 euGenes: HUgn84864
    ECgene: MINA H-InvDB: MINA

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MINA Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MINA Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MINA gene:
    Search GeneIP for patents involving MINA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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