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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MINA Gene

protein-coding   GIFtS: 54
GCID: GC03M097660

MYC induced nuclear antigen
 Explore 9 diseases affiliated with
MINA via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MINA    

Aliases
for MINA gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
MYC Induced Nuclear Antigen1 2     ROX2 3
MINA531 2 3 5     FLJ143931
MDIG2 3 5     Mdig1
Histone Lysine Demethylase MINA2 3     Bifunctional Lysine-Specific Demethylase And Histidyl-Hydroxylase MINA2
Mineral Dust-Induced Gene Protein2 3     Mineral Dust Induced Gene Protein2
Nucleolar Protein 522 3     Myc-Induced Nuclear Antigen, 53 KDa2
Ribosomal Oxygenase MINA2 3     EC 1.14.11.-3
60S Ribosomal Protein L27a Histidine Hydroxylase2 3     MYC-Induced Nuclear Antigen3
NO522 3     

External Ids:    HGNC: 194411   Entrez Gene: 848642   Ensembl: ENSG000001708547   OMIM: 6120495   UniProtKB: Q8IUF83   

Export aliases for MINA gene to outside databases

Previous GC identifers: GC03M098985 GC03M099146 GC03M095030


Summaries
for MINA gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for MINA:
MINA is a c-Myc (MYC; MIM 190080) target gene that may play a role in cell proliferation or regulation of cell growth.
(Tsuneoka et al., 2002 (PubMed 12091391); Zhang et al., 2005 (PubMed 15897898)).(supplied by OMIM, May 2008)

UniProtKB/Swiss-Prot: MINA_HUMAN, Q8IUF8
Function: Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Is
involved in the demethylation of trimethylated 'Lys-9' on histone H3 (H3K9me3), leading to an increase in ribosomal
RNA expression. Also catalyzes the hydroxylation of 60S ribosomal protein L27a on 'His-39'. May play an important role
in cell growth and survival. May be involved in ribosome biogenesis, most likely during the assembly process of
pre-ribosomal particles

Gene Wiki entry for MINA


Genomic Views
for MINA gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_005612.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MINA gene promoter:
         RORalpha1   S8   FOXO3   HNF-3beta   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MINA promoter sequence
   Search SABiosciences Chromatin IP Primers for MINA

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MINA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q11.2   Ensembl cytogenetic band:  3q11.2   HGNC cytogenetic band: 3q22.1

MINA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MINA gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M097660:  view genomic region     (about GC identifiers)

Start:
 97,660,661 bp from pter      End:
 97,691,301 bp from pter
Size:
 30,641 bases      Orientation:
 minus strand

Proteins
for MINA gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MINA_HUMAN, Q8IUF8 (See protein sequence)
Recommended Name: Bifunctional lysine-specific demethylase and histidyl-hydroxylase MINA  
Size: 465 amino acids; 52800 Da
Cofactor: Binds 1 Fe(2+) ion per subunit (By similarity)
Subcellular location: Nucleus. Nucleus, nucleolus
Sequence caution: Sequence=CAH10679.1; Type=Erroneous termination; Positions=431; Note=Translated as Trp;
1 PDB 3D structure from and Proteopedia for MINA:
2XDV (3D)    
Secondary accessions: D3DN35 Q6AHW4 Q6SKS0 Q8IU69 Q8IUF6 Q8IUF7 Q96C17 Q96KB0
Alternative splicing: 4 isoforms:  Q8IUF8-1   Q8IUF8-2   Q8IUF8-3   Q8IUF8-4   

Explore the universe of human proteins at neXtProt for MINA: NX_Q8IUF8

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8IUF8

    • MINA Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (4 alternative transcripts): 
    NP_001035998.1  NP_001248758.1  NP_116167.3  NP_694822.2  

    ENSEMBL proteins: 
     ENSP00000328251   ENSP00000377748   ENSP00000353395   ENSP00000421347   ENSP00000424955  
     ENSP00000424530   ENSP00000423816   ENSP00000327424  

    Human Recombinant Protein Products: 
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    OriGene Purified Protein: MINA
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    Novus Biologicals MINA Protein
    Novus Biologicals MINA Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for MINA

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005667transcription factor complex IEA--
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol IEA--


    MINA for ontologies           About GeneDecksing



    MINA Antibody Products: 
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    Uscn Antibodies for MINA
    ThermoFisher Antibodies for MINA

    Assay Products for MINA: 
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    Uscn ELISAs and CLIAs for MINA

    Protein Domains /
    Families
    for MINA gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MINA for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR013109 NO66/MINA
     IPR003347 JmjC_dom

    Graphical View of Domain Structure for InterPro Entry Q8IUF8

    ProtoNet protein and cluster: Q8IUF8

    2 Blocks protein families:
    IPB003347 Transcription factor jumonji
    IPB013109 Cupin 4


    UniProtKB/Swiss-Prot: MINA_HUMAN, Q8IUF8
    Similarity: Belongs to the MINA53/NO66 family
    Similarity: Contains 1 JmjC domain


    Function
    for MINA gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: MINA_HUMAN, Q8IUF8
    Function: Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Is
    involved in the demethylation of trimethylated 'Lys-9' on histone H3 (H3K9me3), leading to an increase in ribosomal
    RNA expression. Also catalyzes the hydroxylation of 60S ribosomal protein L27a on 'His-39'. May play an important role
    in cell growth and survival. May be involved in ribosome biogenesis, most likely during the assembly process of
    pre-ribosomal particles
    Catalytic activity: L-histidine-[60S ribosomal protein L27a] + 2-oxoglutarate + O(2) = (3S)-3-hydroxy-L-histidine-[60S
    ribosomal protein L27a] + succinate + CO(2)
    Induction: Up-regulated in response to MYC, in alveolar macrophages from coal miners and in silica particle-treated
    A549 lung cancer cells

    Enzyme Number (IUBMB): EC 1.14.11.-1

    miRNA
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    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MINA
    8/45 QIAGEN miScript miRNA Assays for microRNAs that regulate MINA (see all 45):
    hsa-miR-562 hsa-miR-4254 hsa-miR-607 hsa-miR-1245 hsa-miR-1258 hsa-miR-548m hsa-miR-298 hsa-miR-654-5p
    SwitchGear 3'UTR luciferase reporter plasmid: MINA 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MINA (see all 7)
    OriGene shRNA RFP: MINA
    OriGene siRNA: MINA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MINA

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for MINA

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MINA (see all 6)
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): MINA (NM_001042533)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MINA 

    Cell Line
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    Search LifeMap BioReagents cell lines for MINA

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MINA

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001191RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription IEA--
    GO:0016702oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen IEA--
    GO:0046872metal ion binding IEA--


    MINA for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for MINA:
     Decreased number of cells in m 


    Pathways & Interactions
    for MINA gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Validated targets of C-MYC transcriptional activation
    		Validated targets of C-MYC transcriptional activation1.00


    1 BioSystems Pathway for MINA 
        Validated targets of C-MYC transcriptional activation


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MINA

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5/6 Interacting proteins for MINA (Q8IUF82, 3 ENSP000003282514) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MYCP011063, ENSP000003672074I2D: score=2 STRING: ENSP00000367207
    MYBBP1AQ9BQG03, ENSP000003709684I2D: score=1 STRING: ENSP00000370968
    PRKAA1Q131313I2D: score=1 
    MINAQ8IUF82MINT-68176
    MAXENSP000003514904STRING: ENSP00000351490
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0042254ribosome biogenesis IEA--


    MINA for ontologies           About GeneDecksing



    Drugs & Compounds
    for MINA gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MINA
    Search CenterWatch for drugs/clinical trials and news about MINA 

    Transcripts
    for MINA gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MINA gene (4 alternative transcripts): 
    NM_001042533.2  NM_001261829.1  NM_032778.5  NM_153182.3  

    Unigene Cluster for MINA:

    MYC induced nuclear antigen
    Hs.570562  [show with all ESTs]
    Unigene Representative Sequence: NM_001042533
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000333396(uc003dsa.1 uc003drz.1 uc003dsb.1 uc003dsc.1)
    ENST00000394198 ENST00000506682 ENST00000360258 ENST00000503517 ENST00000503097
    ENST00000514314(uc010hpa.1) ENST00000507612 ENST00000506099 ENST00000330299(uc010hpb.1)


    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 3): MINA
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MINA
    8/45 QIAGEN miScript miRNA Assays for microRNAs that regulate MINA (see all 45):
    hsa-miR-562 hsa-miR-4254 hsa-miR-607 hsa-miR-1245 hsa-miR-1258 hsa-miR-548m hsa-miR-298 hsa-miR-654-5p
    SwitchGear 3'UTR luciferase reporter plasmid: MINA 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MINA (see all 7)
    OriGene shRNA RFP: MINA
    OriGene siRNA: MINA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MINA
    Clone
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): MINA (NM_001042533)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MINA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MINA 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MINA
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MINA

    Additional cDNA sequence: 

    AB083189.1 AB083190.1 AB083192.1 AB083193.1 AK027299.1 AY302110.3 AY390536.1 BC014928.1 
    CR627479.1 DQ453796.1 

    10 DOTS entries:

    DT.101977824  DT.95356072  DT.100027234  DT.99944672  DT.95268418  DT.40203063  DT.95148055  DT.97764336 
    DT.100027233  DT.100027235 

    24/135 AceView cDNA sequences (see all 135):

    AI271552 AA464689 AW297807 AA297302 BU676897 Z28710 BI758152 AW263409 
    AI720443 AB083192 BQ001416 BQ002687 BF102569 AI696914 AY302110 CR604605 
    BM993108 AA866035 AY390536 BX360674 BX093929 BQ017091 CR626231 BE463617 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for MINA (see all 9)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b
    SP1:                                                                          -     -                                         -               
    SP2:                                                                          -                                                               
    SP3:                                                                          -     -                                                         
    SP4:                                                                                                                          -               
    SP5:        -     -                                                                                                                           


    ECgene alternative splicing isoforms for MINA

    Expression
    for MINA gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MINA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AAAGAAAGAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See MINA Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MINA

    SOURCE GeneReport for Unigene cluster: Hs.570562

    UniProtKB/Swiss-Prot: MINA_HUMAN, Q8IUF8
    Tissue specificity: Expressed in liver, skeletal muscle, heart, pancreas, and placenta. Not detected in brain, lung or
    kidney. Expressed in several lung cancer tissues, but is barely detected in the adjacent non-cancerous tissues. Also
    highly expressed in several esophageal squamous cell carcinoma (ESCC), and colon cancer tissues, and in various cancer
    cell lines

        SABiosciences Custom PCR Arrays for MINA
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MINA
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MINA

    Orthologs
    for MINA gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MINA gene from 8/25 species (see all 25)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Mina1 , 5 myc induced nuclear antigen1, 5 80.93(n)1
    76.56(a)1    		   16 (34.83 cM)5
    670141  NM_025910.31  NP_080186.31 
     594717755 
    chicken
    (Gallus gallus)    		 Aves MINA1 MYC induced nuclear antigen 70.78(n)
    71.86(a)    		   418436  NM_001079723.1  NP_001073191.1 
    lizard
    (Anolis carolinensis)    		 Reptilia --
    --
    		 --
    		 64(a)
    63(a)
    		 many → 1
    many → 1
    		 3(164055169-164066747)
    2(118718177-118719168)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.148932 Xenopus laevis transcribed sequence with weak similarity more 75.77(n)    BX848254.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc638732 hypothetical protein MGC63873 78.8(n)   393308  BC053125.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG29826
    		 --
    		 17(a)
    		 1 ↔ 1
    		 X(4213473-4215778)
    worm
    (Caenorhabditis elegans)    		 Secernentea jmjc-16
    		 Lysine-specific demethylase NO66
    		 16(a)
    		 1 ↔ 1
    		 I(3631093-3636488)
    rice
    (Oryza sativa)    		 Liliopsida --
    		 expressed protein
    		 13(a)
    		 1 ↔ 1
    		 4(33446573-33449714)


    ENSEMBL Gene Tree for MINA (if available)
    TreeFam Gene Tree for MINA (if available) 

    Paralogs
    for MINA gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MINA gene
    1 SIMAP similar gene for MINA using alignment to 4 protein entries:     MINA_HUMAN (see all proteins):
    NO66

    MINA for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for MINA
    PGOHUM00000248224


    Genomic Variants
    for MINA gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/473 NCBI SNPs in MINA are shown (see all 473)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 3 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs8320891,2
    		C,F,H,--97660198(+) TTTTTG/ATTTTG 5 -- ds5001 int129Minor allele frequency- A:0.25MN EA NA NS WA CSA 2679
    rs1404371671,2
    		--97660443(+) TTGGAA/CAATGT 5 -- ds5001 int10--------
    rs1812093051,2
    		--97660466(+) TGTTCC/TTTACT 5 -- int1 ds50010--------
    rs1441802441,2
    		--97660552(+) AAGCAA/GTAGAA 5 -- int1 ds50010--------
    rs1871255861,2
    		--97660799(+) ACCAAC/GCTCAA 5 -- int1 ut310--------
    rs1914080841,2
    		--97660848(+) TTCCAA/GTTCAC 5 -- int1 ut310--------
    rs1407923871,2
    		C,--97660944(+) ATCTC-/CTACCCAC 5 -- int1 ut310--------
    rs1833745951,2
    		--97660947(+) TCCTAC/TCCACA 5 -- ut31 int10--------
    rs1877786711,2
    		--97661124(+) CCCTTG/TTAGGC 5 -- int1 ut310--------
    rs1426283101,2
    		--97661407(+) AATTAC/TGCTTG 5 -- int1 ut310--------

    HapMap Linkage Disequilibrium report for MINA (97660661 - 97691301 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for MINA: --

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    Disorders / Diseases
    for MINA gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MINA for disorders           About GeneDecksing

    OMIM gene information: 612049    OMIM disorders: --

    9 diseases for MINA:    About MalaCards
    esophageal squamous cell carcinoma    squamous cell carcinoma    renal cell carcinoma    gingivitis
    esophagitis    colon cancer    lung cancer    carcinoma
    asthma


    Export disorders for MINA gene to outside databases

    Publications
    for MINA gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MINA gene, integrated from 9 sources (see all 32):
    (articles sorted by number of sources associating them with MINA)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel myc target gene, mina53, that is involved in cell proliferation. (PubMed id 12091391)1, 2, 3, 9 Tsuneoka M.... Kimura H. (2002)
    2. Lung cancer-associated JmjC domain protein mdig suppresses formation of tri-methyl lysine 9 of histone H3. (PubMed id 19502796)1, 2 Lu Y....Chen F. (2009)
    3. The human mineral dust-induced gene, mdig, is a cell growth regulating gene associated with lung cancer. (PubMed id 15897898)1, 2 Zhang Y.... Chen F. (2005)
    4. Protein NO52 -- a constitutive nucleolar component sharing high sequence homologies to protein NO66. (PubMed id 15819408)1, 2 Eilbracht J.... Schmidt-Zachmann M.S. (2005)
    5. Mina53 as a potential prognostic factor for esophageal squamous cell carcinoma. (PubMed id 15534111)1, 2 Tsuneoka M.... Kimura H. (2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. NO66, a highly conserved dual location protein in the nucleolus and in a special type of synchronously replicating chromatin. (PubMed id 14742713)1, 2 Eilbracht J.... Schmidt-Zachmann M.S. (2004)
    8. Increased expression of a Myc target gene Mina53 in human colon cancer. (PubMed id 14695334)1, 2 Teye K.... Kimura H. (2004)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    10. Oxygenase-catalyzed ribosome hydroxylation occurs in prokaryotes and humans. (PubMed id 23103944)2 Ge W....Schofield C.J. (2012)

    External Searches for MINA gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    NCBI Bookshelf
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    Genome Databases showing MINA gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 84864 HGNC: 19441 AceView: MINA Ensembl:ENSG00000170854 euGenes: HUgn84864
    ECgene: MINA H-InvDB: MINA

    Other Databases showing MINA gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing MINA gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MINA Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for MINA gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MINA gene:
    Search GeneIP for patents involving MINA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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