Aliases for MINA Gene
External Ids for MINA Gene
Previous GeneCards Identifiers for MINA Gene
MINA is a c-Myc (MYC; MIM 190080) target gene that may play a role in cell proliferation or regulation of cell growth. (Tsuneoka et al., 2002 [PubMed 12091391]; Zhang et al., 2005 [PubMed 15897898]).[supplied by OMIM, May 2008]
GeneCards Summary for MINA Gene
MINA (MYC Induced Nuclear Antigen) is a Protein Coding gene. Diseases associated with MINA include lung cancer. Among its related pathways are Validated targets of C-MYC transcriptional activation. GO annotations related to this gene include dioxygenase activity and transcriptional repressor activity, RNA polymerase II transcription factor binding.
UniProtKB/Swiss-Prot for MINA Gene
Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Is involved in the demethylation of trimethylated Lys-9 on histone H3 (H3K9me3), leading to an increase in ribosomal RNA expression. Also catalyzes the hydroxylation of 60S ribosomal protein L27a on His-39. May play an important role in cell growth and survival. May be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles.