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Aliases for MINA Gene

Aliases for MINA Gene

  • MYC Induced Nuclear Antigen 2 3 5
  • 60S Ribosomal Protein L27a Histidine Hydroxylase 3 4
  • Histone Lysine Demethylase MINA 3 4
  • Ribosomal Oxygenase MINA 3 4
  • Nucleolar Protein 52 3 4
  • MINA53 3 4
  • MDIG 3 4
  • NO52 3 4
  • ROX 3 4
  • Bifunctional Lysine-Specific Demethylase And Histidyl-Hydroxylase MINA 3
  • Myc-Induced Nuclear Antigen, 53 KDa 3
  • Mineral Dust Induced Gene Protein 3
  • Mineral Dust-Induced Gene Protein 4
  • MYC-Induced Nuclear Antigen 4
  • EC 1.14.11.- 4

External Ids for MINA Gene

Previous GeneCards Identifiers for MINA Gene

  • GC03M098985
  • GC03M099146
  • GC03M097660
  • GC03M095030

Summaries for MINA Gene

Entrez Gene Summary for MINA Gene

  • MINA is a c-Myc (MYC; MIM 190080) target gene that may play a role in cell proliferation or regulation of cell growth. (Tsuneoka et al., 2002 [PubMed 12091391]; Zhang et al., 2005 [PubMed 15897898]).[supplied by OMIM, May 2008]

GeneCards Summary for MINA Gene

MINA (MYC Induced Nuclear Antigen) is a Protein Coding gene. Diseases associated with MINA include Lung Cancer. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Chromatin organization. GO annotations related to this gene include dioxygenase activity and transcriptional repressor activity, RNA polymerase II transcription factor binding. An important paralog of this gene is C14orf169.

UniProtKB/Swiss-Prot for MINA Gene

  • Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Is involved in the demethylation of trimethylated Lys-9 on histone H3 (H3K9me3), leading to an increase in ribosomal RNA expression. Also catalyzes the hydroxylation of 60S ribosomal protein L27a on His-39. May play an important role in cell growth and survival. May be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles.

Gene Wiki entry for MINA Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MINA Gene

Genomics for MINA Gene

Regulatory Elements for MINA Gene

Enhancers for MINA Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F097882 1.3 Ensembl ENCODE 15.1 +89.5 89467 0.8 GATA3 JUND SMARCA4 HMBOX1 FEZF1 EZH2 MINA LOC105373994
GH03F098003 0.6 Ensembl 11.9 -31.2 -31244 0.6 SPI1 MINA ARL6 ST3GAL6-AS1 GABRR3
GH03F097910 0.9 Ensembl ENCODE 11.4 +61.4 61386 1.7 HDAC1 ATF1 PKNOX1 ARNT TBL1XR1 NFRKB GATA2 ETV6 ZBTB2 NCOA1 MINA CRYBG3 LOC105373994
GH03F098012 0.9 Ensembl ENCODE 10.9 -41.1 -41123 1.2 SOX13 CTCF PKNOX1 JUN CEBPG ZNF48 PRDM10 FOS TCF7L2 SOX5 CRYBG3 MINA ARL6 GABRR3
GH03F097820 0.7 ENCODE 10.5 +150.0 149978 3.1 TBP ZNF76 SIN3A DMAP1 ZNF48 YY1 EGR1 ZNF366 SCRT2 ZNF143 MINA CRYBG3 LOC105373994
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MINA on UCSC Golden Path with GeneCards custom track

Promoters for MINA Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001368910 657 2801 HDGF PKNOX1 WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF48 YY1 CBX5

Genomic Location for MINA Gene

Chromosome:
3
Start:
97,941,817 bp from pter
End:
97,972,457 bp from pter
Size:
30,641 bases
Orientation:
Minus strand

Genomic View for MINA Gene

Genes around MINA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MINA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MINA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MINA Gene

Proteins for MINA Gene

  • Protein details for MINA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IUF8-MINA_HUMAN
    Recommended name:
    Bifunctional lysine-specific demethylase and histidyl-hydroxylase MINA
    Protein Accession:
    Q8IUF8
    Secondary Accessions:
    • D3DN35
    • Q6AHW4
    • Q6SKS0
    • Q8IU69
    • Q8IUF6
    • Q8IUF7
    • Q96C17
    • Q96KB0

    Protein attributes for MINA Gene

    Size:
    465 amino acids
    Molecular mass:
    52800 Da
    Cofactor:
    Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAH10679.1; Type=Erroneous termination; Positions=431; Note=Translated as Trp.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MINA Gene

    Alternative splice isoforms for MINA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MINA Gene

Post-translational modifications for MINA Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for MINA

No data available for DME Specific Peptides for MINA Gene

Domains & Families for MINA Gene

Protein Domains for MINA Gene

Suggested Antigen Peptide Sequences for MINA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IUF8

UniProtKB/Swiss-Prot:

MINA_HUMAN :
  • Contains 1 JmjC domain.
  • Belongs to the ROX family. MINA53 subfamily.
Domain:
  • Contains 1 JmjC domain.
Family:
  • Belongs to the ROX family. MINA53 subfamily.
genes like me logo Genes that share domains with MINA: view

No data available for Gene Families for MINA Gene

Function for MINA Gene

Molecular function for MINA Gene

UniProtKB/Swiss-Prot CatalyticActivity:
L-histidine-[60S ribosomal protein L27a] + 2-oxoglutarate + O(2) = (3S)-3-hydroxy-L-histidine-[60S ribosomal protein L27a] + succinate + CO(2).
UniProtKB/Swiss-Prot Function:
Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Is involved in the demethylation of trimethylated Lys-9 on histone H3 (H3K9me3), leading to an increase in ribosomal RNA expression. Also catalyzes the hydroxylation of 60S ribosomal protein L27a on His-39. May play an important role in cell growth and survival. May be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles.
UniProtKB/Swiss-Prot Induction:
Up-regulated in response to MYC, in alveolar macrophages from coal miners and in silica particle-treated A549 lung cancer cells.

Enzyme Numbers (IUBMB) for MINA Gene

Gene Ontology (GO) - Molecular Function for MINA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding IEA --
GO:0005506 iron ion binding IBA --
GO:0016491 oxidoreductase activity IEA --
GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors IBA --
GO:0042802 identical protein binding IPI 16189514
genes like me logo Genes that share ontologies with MINA: view
genes like me logo Genes that share phenotypes with MINA: view

Animal Models for MINA Gene

MGI Knock Outs for MINA:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MINA Gene

Localization for MINA Gene

Subcellular locations from UniProtKB/Swiss-Prot for MINA Gene

Nucleus. Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MINA Gene COMPARTMENTS Subcellular localization image for MINA gene
Compartment Confidence
nucleus 5
cytosol 4

Gene Ontology (GO) - Cellular Components for MINA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005667 transcription factor complex IEA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with MINA: view

Pathways & Interactions for MINA Gene

genes like me logo Genes that share pathways with MINA: view

Pathways by source for MINA Gene

Gene Ontology (GO) - Biological Process for MINA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0018193 peptidyl-amino acid modification IBA --
GO:0042254 ribosome biogenesis IEA,IBA --
genes like me logo Genes that share ontologies with MINA: view

No data available for SIGNOR curated interactions for MINA Gene

Drugs & Compounds for MINA Gene

(2) Drugs for MINA Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Oxygen Approved, Vet_approved Pharma 0
Succinic acid Approved Nutra Full agonist, Agonist 0

(1) Additional Compounds for MINA Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Oxoglutaric acid
  • 2-Ketoglutarate
  • 2-Ketoglutaric acid
  • 2-Oxo-1,5-pentanedioate
  • 2-Oxo-1,5-pentanedioic acid
  • 2-Oxoglutarate
328-50-7
genes like me logo Genes that share compounds with MINA: view

Transcripts for MINA Gene

Unigene Clusters for MINA Gene

MYC induced nuclear antigen:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MINA Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b
SP1: - - -
SP2: -
SP3: - -
SP4: -
SP5: - -
SP6:
SP7: -
SP8:
SP9:

Relevant External Links for MINA Gene

GeneLoc Exon Structure for
MINA
ECgene alternative splicing isoforms for
MINA

Expression for MINA Gene

mRNA expression in normal human tissues for MINA Gene

Protein differential expression in normal tissues from HIPED for MINA Gene

This gene is overexpressed in Breast (59.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MINA Gene



Protein tissue co-expression partners for MINA Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MINA Gene:

MINA

SOURCE GeneReport for Unigene cluster for MINA Gene:

Hs.570562

mRNA Expression by UniProt/SwissProt for MINA Gene:

Q8IUF8-MINA_HUMAN
Tissue specificity: Expressed in liver, skeletal muscle, heart, pancreas, and placenta. Not detected in brain, lung or kidney. Expressed in several lung cancer tissues, but is barely detected in the adjacent non-cancerous tissues. Also highly expressed in several esophageal squamous cell carcinoma (ESCC), and colon cancer tissues, and in various cancer cell lines.
genes like me logo Genes that share expression patterns with MINA: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for MINA Gene

Orthologs for MINA Gene

This gene was present in the common ancestor of animals.

Orthologs for MINA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MINA 34 35
  • 99.43 (n)
cow
(Bos Taurus)
Mammalia MINA 34 35
  • 85.76 (n)
rat
(Rattus norvegicus)
Mammalia Mina 34
  • 82.15 (n)
mouse
(Mus musculus)
Mammalia Mina 34 16 35
  • 80.93 (n)
dog
(Canis familiaris)
Mammalia MINA 34 35
  • 80.13 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MINA 35
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MINA 35
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves MINA 34 35
  • 70.78 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 64 (a)
OneToMany
-- 35
  • 64 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia mina 34
  • 59.19 (n)
Str.7087 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.14893 34
zebrafish
(Danio rerio)
Actinopterygii minal 34 35
  • 59.7 (n)
zgc63873 34
fruit fly
(Drosophila melanogaster)
Insecta CG2982 35
  • 18 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea jmjc-1 35
  • 17 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8544 35
  • 36 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.10438 34
Species where no ortholog for MINA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MINA Gene

ENSEMBL:
Gene Tree for MINA (if available)
TreeFam:
Gene Tree for MINA (if available)

Paralogs for MINA Gene

Paralogs for MINA Gene

(1) SIMAP similar genes for MINA Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with MINA: view

Variants for MINA Gene

Sequence variations from dbSNP and Humsavar for MINA Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs10542689 -- 97,962,357(+) TAAGA(-/C)CCCCC intron-variant
rs10644219 -- 97,965,229(+) AAAAA(-/A/AAA)GGCCC intron-variant
rs111366380 -- 97,947,632(+) ACATC(A/G)TTATG intron-variant
rs111422927 -- 97,957,267(+) GCCGA(A/G)GCAGG intron-variant
rs111454975 -- 97,967,285(+) CACCG(A/G)CAGAC nc-transcript-variant, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for MINA Gene

Variant ID Type Subtype PubMed ID
nsv1012322 CNV gain 25217958
nsv1013060 CNV gain 25217958
nsv520553 CNV gain 19592680

Variation tolerance for MINA Gene

Residual Variation Intolerance Score: 87% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.87; 93.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MINA Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MINA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MINA Gene

Disorders for MINA Gene

MalaCards: The human disease database

(1) MalaCards diseases for MINA Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
lung cancer
  • lung cancer, protection against
- elite association - COSMIC cancer census association via MalaCards
Search MINA in MalaCards View complete list of genes associated with diseases

Relevant External Links for MINA

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MINA
genes like me logo Genes that share disorders with MINA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MINA Gene

Publications for MINA Gene

  1. A novel myc target gene, mina53, that is involved in cell proliferation. (PMID: 12091391) Tsuneoka M. … Kimura H. (J. Biol. Chem. 2002) 2 3 4 22 64
  2. Lung cancer-associated JmjC domain protein mdig suppresses formation of tri-methyl lysine 9 of histone H3. (PMID: 19502796) Lu Y. … Chen F. (Cell Cycle 2009) 3 4 64
  3. Protein NO52 -- a constitutive nucleolar component sharing high sequence homologies to protein NO66. (PMID: 15819408) Eilbracht J. … Schmidt-Zachmann M.S. (Eur. J. Cell Biol. 2005) 3 4 64
  4. The human mineral dust-induced gene, mdig, is a cell growth regulating gene associated with lung cancer. (PMID: 15897898) Zhang Y. … Chen F. (Oncogene 2005) 3 4 64
  5. Increased expression of a Myc target gene Mina53 in human colon cancer. (PMID: 14695334) Teye K. … Kimura H. (Am. J. Pathol. 2004) 3 4 64

Products for MINA Gene

Sources for MINA Gene

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