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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MILR1 Gene

protein-coding   GIFtS: 33
GCID: GC17P062462

Mast Cell Immunoglobulin-Like Receptor 1

(Previous name: chromosome 17 open reading frame 60)
(Previous symbol: C17orf60)
  Search for MILR1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Mast Cell Immunoglobulin-Like Receptor 11 2 3     Chromosome 17 Open Reading Frame 601
C17orf601 2 3     ALLERGIN-1L2
Allergy Inhibitory Receptor 11 2 3     ALLERGIN-1S12
Mast Cell Antigen 321 2 3     Allergin-12
MCA-322 3     allergin-12
MCA322 3     Probable Mast Cell Antigen 32 Homolog2

External Ids:    HGNC: 275701   Entrez Gene: 2840212   Ensembl: ENSG000002716057   UniProtKB: Q7Z6M33   

Export aliases for MILR1 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for MILR1 Gene: 
MILR1 (mast cell immunoglobulin-like receptor 1) is a protein-coding gene.

UniProtKB/Swiss-Prot: MILR1_HUMAN, Q7Z6M3
Function: Immunoglobulin-like receptor which plays an inhibitory role in degranulation of mast cells. Negatively
regulates IgE-mediated mast cell activation and suppresses the type I immediate hypersensitivity reaction (By
similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.2  NT_010783.15  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for MILR1
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for MILR1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MILR1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q23.3   Ensembl cytogenetic band:  17q23.3   HGNC cytogenetic band: 17q23.3

MILR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MILR1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P062462:  view genomic region     (about GC identifiers)

Start:
62,461,567 bp from pter      End:
62,464,760 bp from pter
Size:
3,194 bases      Orientation:
plus strand

1 alternative location:
Chr17+,NW_003315947 252,962-272,490     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
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About This Section

UniProtKB/Swiss-Prot: MILR1_HUMAN, Q7Z6M3 (See protein sequence)
Recommended Name: Allergin-1 precursor  
Size: 343 amino acids; 38735 Da
Subunit: Monomer (By similarity). Interacts (tyrosine-phosphorylated) with PTPN6, PTPN11 and INPP5D (By
similarity)
Subcellular location: Cell membrane; Single-pass type I membrane protein
Sequence caution: Sequence=AAI36595.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAG62433.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: A1L458 B4DUS1 B7ZM50 B9EGN0 D6RUW6 D6RUW8
Alternative splicing: 3 isoforms:  Q7Z6M3-1   Q7Z6M3-2   Q7Z6M3-3   

Explore the universe of human proteins at neXtProt for MILR1: NX_Q7Z6M3

Explore proteomics data for MILR1 at MOPED 

Post-translational modifications:

  • UniProtKB: N-glycosylated
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q7Z6M3

  • MILR1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MILR1 Protein Expression
    REFSEQ proteins: NP_001078892.1  
    ENSEMBL proteins: 
     ENSP00000474549   ENSP00000474420  

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    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral to plasma membrane NAS--

    MILR1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing

    2 InterPro protein domains:
     IPR013783 Ig-like_fold
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry Q7Z6M3

    ProtoNet protein and cluster: Q7Z6M3

    UniProtKB/Swiss-Prot: MILR1_HUMAN, Q7Z6M3
    Similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains


    MILR1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MILR1_HUMAN, Q7Z6M3
    Function: Immunoglobulin-like receptor which plays an inhibitory role in degranulation of mast cells. Negatively
    regulates IgE-mediated mast cell activation and suppresses the type I immediate hypersensitivity reaction (By
    similarity)

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    MILR1 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Milr1):
     immune system 

    MILR1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Milr1tm1Shib for MILR1

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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MILR1

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0033004negative regulation of mast cell activation ISS--
    GO:0043303mast cell degranulation ISS--

    MILR1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MILR1

    Search CenterWatch for drugs/clinical trials and news about MILR1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MILR1 gene: 
    NM_001085423.1  

    Unigene Cluster for MILR1:

    Mast cell immunoglobulin-like receptor 1
    Hs.631749  [show with all ESTs]
    Unigene Representative Sequence: AK300768
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000603557 ENST00000605096
    miRNA
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    Additional mRNA sequence: 

    AB542950.1 AB542951.1 AB542952.1 AK300768.1 BC014523.1 BC018972.1 BC053534.1 BC130406.1 
    BC136594.1 BC144272.1 

    4 DOTS entries:

    DT.97846407  DT.100748485  DT.120899175  DT.97825468 

    24/46 AceView cDNA sequences (see all 46):

    BQ684458 BC018972 BU184713 BE514055 BU162752 CB151283 BQ883718 CB110038 
    BC053534 BQ677966 BU164411 BU168851 BE269997 BQ680512 BQ683770 BM042081 
    BU196027 BU151556 BU174151 BQ889000 BQ375072 CD687595 AA809265 AW868340 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MILR1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTCGACCTC
    MILR1 Expression
    About this image


    See MILR1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MILR1

    SOURCE GeneReport for Unigene cluster: Hs.631749

    UniProtKB/Swiss-Prot: MILR1_HUMAN, Q7Z6M3
    Tissue specificity: Expressed in myeloid cells (dendritic cells, macrophages and neutrophils, weak expression on
    B-cells but not in T-cells or natural killer cells), peripheral blood basophils and mast cells (at protein level)

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MILR1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for MILR1 gene from 2/6 species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Milr15 predicted gene 885   --   11 (70.00 cM) 106751226 
    chicken
    (Gallus gallus)
    Aves MILR11 mast cell immunoglobulin-like receptor 1 50(n)
    37.96(a)
      417417  XM_415669.3  XP_415669.3 


    ENSEMBL Gene Tree for MILR1 (if available)
    TreeFam Gene Tree for MILR1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/76 SNPs in MILR1 are shown (see all 76)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1466989201,2
    --62461116(+) AGGAAA/GATCGC 1 -- int10--------
    rs3682225351,2
    C--62461598(+) CCAGGA/GACCGT 2 N D mis10--------
    rs1910863521,2
    C--62461656(+) ACAAGC/AAAGTA 2 /E /A mis11Minor allele frequency- A:0.00EU 569
    rs1480973341,2
    C--62461676(+) TGTTGC/TGTGTT 1 -- int10--------
    rs80676311,2
    C,F,H--62461759(+) AAAAGG/AGATAG 1 -- int15Minor allele frequency- A:0.02NS EA WA 534
    rs588896271,2
    C,F--62462368(+) CATGAG/AATGTG 1 -- int11Minor allele frequency- A:0.05EA 120
    rs116577691,2
    C,H--62462402(+) agatgA/Tgattt 1 -- int10--------
    rs1420270841,2
    C--62462567(+) AGGAAA/TCTGTG 2 T S mis10--------
    rs1460087851,2
    C--62462593(+) AGGCCA/GTGTGT 2 P syn10--------
    rs3765403131,2
    C--62462689(+) AATTCC/TTATTC 1 -- int10--------

    HapMap Linkage Disequilibrium report for MILR1 (62461567 - 62464760 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for MILR1: --
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MILR1 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with MILR1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. An immunoglobulin-like receptor, Allergin-1, inhibits immunoglobulin E-mediated immediate hypersensitivity reactions. (PubMed id 20526344)1, 2, 3 Hitomi K.... Shibuya A. (2010)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 284021 HGNC: 27570 AceView: LOC284021 Ensembl:ENSG00000271605 euGenes: HUgn284021
    ECgene: MILR1 H-InvDB: MILR1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MILR1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MILR1 gene:
    Search GeneIP for patents involving MILR1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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