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Aliases for MILR1 Gene

Aliases for MILR1 Gene

  • Mast Cell Immunoglobulin-Like Receptor 1 2 3 4
  • Allergy Inhibitory Receptor 1 2 3 4
  • Mast Cell Antigen 32 2 3 4
  • C17orf60 3 4
  • MCA-32 3 4
  • MCA32 3 4
  • Probable Mast Cell Antigen 32 Homolog 3
  • Chromosome 17 Open Reading Frame 60 2
  • Allergin-1 3

External Ids for MILR1 Gene

Previous Symbols for MILR1 Gene

  • C17orf60

Summaries for MILR1 Gene

GeneCards Summary for MILR1 Gene

MILR1 (Mast Cell Immunoglobulin-Like Receptor 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for MILR1 Gene

  • Immunoglobulin-like receptor which plays an inhibitory role in degranulation of mast cells. Negatively regulates IgE-mediated mast cell activation and suppresses the type I immediate hypersensitivity reaction (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MILR1 Gene

Genomics for MILR1 Gene

Genomic Location for MILR1 Gene

Start:
64,447,182 bp from pter
End:
64,492,396 bp from pter
Size:
45,215 bases
Orientation:
Plus strand

Genomic View for MILR1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MILR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MILR1 Gene

No data available for Regulatory Elements for MILR1 Gene

Proteins for MILR1 Gene

  • Protein details for MILR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z6M3-MILR1_HUMAN
    Recommended name:
    Allergin-1
    Protein Accession:
    Q7Z6M3
    Secondary Accessions:
    • A1L458
    • B4DUS1
    • B7ZM50
    • B9EGN0
    • D6RUW6
    • D6RUW8

    Protein attributes for MILR1 Gene

    Size:
    343 amino acids
    Molecular mass:
    38735 Da
    Quaternary structure:
    • Monomer. Interacts (tyrosine-phosphorylated) with PTPN6, PTPN11 and INPP5D.
    SequenceCaution:
    • Sequence=AAI36595.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAG62433.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for MILR1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MILR1 Gene

Proteomics data for MILR1 Gene at MOPED

Post-translational modifications for MILR1 Gene

No data available for DME Specific Peptides for MILR1 Gene

Domains for MILR1 Gene

Gene Families for MILR1 Gene

HGNC:
  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing

Protein Domains for MILR1 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

MILR1_HUMAN
Domain:
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.:
    • Q7Z6M3
genes like me logo Genes that share domains with MILR1: view

Function for MILR1 Gene

Molecular function for MILR1 Gene

UniProtKB/Swiss-Prot Function: Immunoglobulin-like receptor which plays an inhibitory role in degranulation of mast cells. Negatively regulates IgE-mediated mast cell activation and suppresses the type I immediate hypersensitivity reaction (By similarity).

Gene Ontology (GO) - Molecular Function for MILR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with MILR1: view

Phenotypes for MILR1 Gene

genes like me logo Genes that share phenotypes with MILR1: view

Animal Models for MILR1 Gene

MGI Knock Outs for MILR1:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for MILR1 Gene

Localization for MILR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MILR1 Gene

Cell membrane; Single-pass type I membrane protein.

Gene Ontology (GO) - Cellular Components for MILR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane NAS 20526344
GO:0042629 mast cell granule ISS --
genes like me logo Genes that share ontologies with MILR1: view

Pathways for MILR1 Gene

SuperPathways for MILR1 Gene

No Data Available

Interacting Proteins for MILR1 Gene

Gene Ontology (GO) - Biological Process for MILR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0033004 negative regulation of mast cell activation ISS --
GO:0043303 mast cell degranulation ISS --
genes like me logo Genes that share ontologies with MILR1: view

No data available for Pathways by source for MILR1 Gene

Transcripts for MILR1 Gene

Unigene Clusters for MILR1 Gene

Mast cell immunoglobulin-like receptor 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MILR1 Gene

No ASD Table

Relevant External Links for MILR1 Gene

GeneLoc Exon Structure for
MILR1
ECgene alternative splicing isoforms for
MILR1

Expression for MILR1 Gene

mRNA expression in normal human tissues for MILR1 Gene

mRNA differential expression in normal tissues according to GTEx for MILR1 Gene

This gene is overexpressed in Whole Blood (13.9) and Spleen (4.7).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for MILR1 Gene

SOURCE GeneReport for Unigene cluster for MILR1 Gene Hs.631749

mRNA Expression by UniProt/SwissProt for MILR1 Gene

Q7Z6M3-MILR1_HUMAN
Tissue specificity: Expressed in myeloid cells (dendritic cells, macrophages and neutrophils, weak expression on B-cells but not in T-cells or natural killer cells), peripheral blood basophils and mast cells (at protein level).
genes like me logo Genes that share expressions with MILR1: view

Orthologs for MILR1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MILR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MILR1 36
  • 98.54 (n)
  • 97.08 (a)
MILR1 37
  • 22 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MILR1 36
  • 77.25 (n)
  • 62.91 (a)
MILR1 37
  • 14 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MILR1 36
  • 78.34 (n)
  • 63.8 (a)
MILR1 37
  • 15 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Milr1 16
Milr1 37
  • 6 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MILR1 37
  • 3 (a)
OneToOne
chicken
(Gallus gallus)
Aves MILR1 36
  • 47.56 (n)
  • 36.18 (a)
MILR1 37
  • 2 (a)
OneToOne
Species with no ortholog for MILR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MILR1 Gene

ENSEMBL:
Gene Tree for MILR1 (if available)
TreeFam:
Gene Tree for MILR1 (if available)

Paralogs for MILR1 Gene

No data available for Paralogs for MILR1 Gene

Variants for MILR1 Gene

Sequence variations from dbSNP and Humsavar for MILR1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs4077660 -- 64,455,486(+) TCTTG(C/T)TCTGT intron-variant
rs6504230 -- 64,448,998(+) TCTTA(C/T)AGGAA upstream-variant-2KB, intron-variant
rs7211797 -- 64,452,178(+) agtga(C/T)cctcc intron-variant
rs7213455 -- 64,448,440(+) GTTTA(A/T)CAAAA upstream-variant-2KB, intron-variant
rs7213906 -- 64,448,632(+) aggag(C/G)ctgag upstream-variant-2KB, intron-variant

Relevant External Links for MILR1 Gene

HapMap Linkage Disequilibrium report
MILR1

No data available for Structural Variations from Database of Genomic Variants (DGV) for MILR1 Gene

Disorders for MILR1 Gene

No disorders were found for MILR1 Gene.

No data available for UniProtKB/Swiss-Prot for MILR1 Gene

Publications for MILR1 Gene

  1. An immunoglobulin-like receptor, Allergin-1, inhibits immunoglobulin E-mediated immediate hypersensitivity reactions. (PMID: 20526344) Hitomi K. … Shibuya A. (Nat. Immunol. 2010) 2 3 4
  2. Expression and function of Allergin-1 on human primary mast cells. (PMID: 24116093) Nagai K. … Shibuya A. (PLoS ONE 2013) 3
  3. [Immunoglobulin-like receptor, allergin-1 regulates the activation of mast cells]. (PMID: 24552759) Tahara-Hanaoka S. … Shibuya A. (Arerugi 2013) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4

Products for MILR1 Gene

  • QIAGEN qRT-PCR Assays for microRNAs that regulate MILR1
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for MILR1
    • Block miRNA regulation of MILR1 using miScript Target Protectors

    Sources for MILR1 Gene

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