MILR1 Gene
protein-coding GIFtS: 31
GCID: GC17P062462
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mast cell immunoglobulin-like receptor 1(Previous name: chromosome 17 open reading frame 60 )
(Previous symbol: C17orf60)
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Aliases
for MILR1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Mast Cell Immunoglobulin-Like Receptor 11 2 3 | | MCA322 3 | | C17orf601 2 3 | | Chromosome 17 Open Reading Frame 601 | | MCA-321 2 3 | | ALLERGIN-1L2 | | Allergin-11 2 | | ALLERGIN-1S12 | | Allergy Inhibitory Receptor 12 3 | | Allergin-11 2 | | Mast Cell Antigen 322 3 | | Probable Mast Cell Antigen 32 Homolog2 |
Export aliases for MILR1 gene to outside databases |
Summaries
for MILR1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: MILR1_HUMAN, Q7Z6M3Function: Immunoglobulin-like receptor which plays an inhibitory role in degranulation of mast cells. Negativelyregulates IgE-mediated mast cell activation and suppresses the type I immediate hypersensitivity reaction (Bysimilarity)
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Genomic Views
for MILR1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010783.15
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for MILR1
Other transcription factors
Search SABiosciences Chromatin IP Primers for MILR1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MILR1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q23.3 HGNC cytogenetic band: 17q23.3MILR1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P062462: view genomic region
(about GC identifiers)
Start:
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62,461,566 bp from pter |
End:
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62,464,760 bp from pter |
Size:
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3,195 bases |
Orientation:
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plus strand |
1 alternative location:
| Chr17+,PATCHES 62,485,854-62,505,382 |
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Proteins
for MILR1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MILR1_HUMAN, Q7Z6M3 (See
protein sequence)Recommended Name: Allergin-1 precursor Size: 343 amino acids; 38735 Da
Subunit: Monomer (By similarity). Interacts (tyrosine-phosphorylated) with PTPN6, PTPN11 and INPP5D (By similarity)
Subcellular location: Cell membrane; Single-pass type I membrane protein
Sequence caution: Sequence=AAI36595.1; Type=Erroneous initiation; Note=Translation N-terminally extended;Sequence=BAG62433.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: A1L458 B4DUS1 B7ZM50 B9EGN0 D6RUW6 D6RUW8Alternative splicing: 3 isoforms: Q7Z6M3-1 Q7Z6M3-2 Q7Z6M3-3 Explore the universe of human proteins at neXtProt for MILR1: NX_Q7Z6M3
Post-translational modifications:
N-glycosylated1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q7Z6M3
MILR1 Protein expression data from MOPED and PaxDb: --
REFSEQ proteins: NP_001078892.1
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005887 | integral to plasma membrane |
NAS | -- |
MILR1 for ontologies About GeneDecksing
MILR1 Antibody Products:
Assay Products for MILR1: |
Protein
Domains /
Families
for MILR1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MILR1 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q7Z6M3ProtoNet protein and cluster: Q7Z6M3 UniProtKB/Swiss-Prot: MILR1_HUMAN, Q7Z6M3Similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains |
Function
for MILR1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: MILR1_HUMAN, Q7Z6M3Function: Immunoglobulin-like receptor which plays an inhibitory role in degranulation of mast cells. Negativelyregulates IgE-mediated mast cell activation and suppresses the type I immediate hypersensitivity reaction (Bysimilarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MILR1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MILR1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript Custom all cDNA clones Services for MILR1 | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MILR1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MILR1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MILR1 |
Animal Models:
Mouse knock-out Milr1tm1Shib for MILR1
1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Milr1):
MILR1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for MILR1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MILR1
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0033004 | negative regulation of mast cell activation |
ISS | -- | | GO:0043303 | mast cell degranulation |
ISS | -- |
MILR1 for ontologies About GeneDecksing
|
Drugs & Compounds
for MILR1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MILR1
Search CenterWatch for drugs/clinical trials and news about MILR1
|
Transcripts
for MILR1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MILR1 gene: NM_001085423.1 Unigene Cluster for MILR1: Mast cell immunoglobulin-like receptor 1 Hs.631749 [show with all ESTs]Unigene Representative Sequence: AK300768
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MILR1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MILR1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for MILR1 | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MILR1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MILR1 |
Additional cDNA sequence: AB542950.1 AB542951.1 AB542952.1 AK300768.1 BC014523.1 BC018972.1 BC053534.1 BC130406.1 BC136594.1 BC144272.1 4 DOTS entries: DT.97846407 DT.100748485 DT.120899175 DT.97825468 24/46 AceView cDNA sequences (see all 46): CB151283 BU196027 BQ684458 BU174151 BU151556 BE269997 BQ683770 BE514055 BC053534 BU162752 BU164411 BC018972 BU184713 BQ677966 BU168851 CB110038 BQ883718 BQ680512 BQ889000 BM042081 BQ878037 BG475211 CA421348 BU177778
GeneLoc Exon Structure
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Expression
for MILR1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MILR1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCTCGACCTC
About this image
Genevestigator expression for MILR1
SOURCE GeneReport for Unigene cluster: Hs.631749
UniProtKB/Swiss-Prot: MILR1_HUMAN, Q7Z6M3Tissue specificity: Expressed in myeloid cells (dendritic cells, macrophages and neutrophils, weak expression onB-cells but not in T-cells or natural killer cells), peripheral blood basophils and mast cells (at protein level)
SABiosciences Custom PCR Arrays for MILR1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MILR1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat MILR1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MILR1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MILR1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MILR1 |
Orthologs
for MILR1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for MILR1 gene from 2/4 species (see all 4) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Milr15 |
predicted gene 885 |
-- |
|
11 (70.00 cM) 106751203 |
chicken
(Gallus gallus) |
Aves |
MILR11 |
mast cell immunoglobulin-like receptor 1 |
50(n)
37.96(a) |
|
417417 XM_415669.3 XP_415669.3 |
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Paralogs
for MILR1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for MILR1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MILR1 (62461566 - 62464760 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MILR1: -- | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for MILR1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for MILR1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MILR1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with MILR1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- An immunoglobulin-like receptor, Allergin-1, inhibits immunoglobulin E-mediated immediate hypersensitivity reactions. (PubMed id 20526344)1, 2, 3 Hitomi K.... Shibuya A. (2010)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for MILR1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing MILR1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MILR1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MILR1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MILR1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for MILR1 gene:
Search GeneIP for patents involving MILR1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MILR1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for MILR1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MILR1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MILR1 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MILR1 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MILR1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MILR1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for MILR1 | | OriGene Custom Protein Services for MILR1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MILR1 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MILR1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MILR1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MILR1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MILR1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MILR1 |
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 | | | MILR1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MILR1 |
|  |  |  | | | | Search ThermoFisher Antibodies for MILR1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MILR1 |
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