Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MILR1 Gene

Aliases for MILR1 Gene

  • Mast Cell Immunoglobulin Like Receptor 1 2 3
  • Mast Cell Immunoglobulin-Like Receptor 1 2 3 4 5
  • Allergy Inhibitory Receptor 1 2 3 4
  • Mast Cell Antigen 32 2 3 4
  • C17orf60 3 4
  • MCA-32 3 4
  • MCA32 3 4
  • Probable Mast Cell Antigen 32 Homolog 3
  • Chromosome 17 Open Reading Frame 60 2
  • Allergin-1 3

External Ids for MILR1 Gene

Previous HGNC Symbols for MILR1 Gene

  • C17orf60

Previous GeneCards Identifiers for MILR1 Gene

  • GC17P062462

Summaries for MILR1 Gene

GeneCards Summary for MILR1 Gene

MILR1 (Mast Cell Immunoglobulin Like Receptor 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for MILR1 Gene

  • Immunoglobulin-like receptor which plays an inhibitory role in degranulation of mast cells. Negatively regulates IgE-mediated mast cell activation and suppresses the type I immediate hypersensitivity reaction (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MILR1 Gene

Genomics for MILR1 Gene

Regulatory Elements for MILR1 Gene

Enhancers for MILR1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MILR1 on UCSC Golden Path with GeneCards custom track

Genomic Location for MILR1 Gene

Chromosome:
17
Start:
64,447,249 bp from pter
End:
64,479,383 bp from pter
Size:
32,135 bases
Orientation:
Plus strand

Genomic View for MILR1 Gene

Genes around MILR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MILR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MILR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MILR1 Gene

Proteins for MILR1 Gene

  • Protein details for MILR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z6M3-MILR1_HUMAN
    Recommended name:
    Allergin-1
    Protein Accession:
    Q7Z6M3
    Secondary Accessions:
    • A1L458
    • B4DUS1
    • B7ZM50
    • B9EGN0
    • D6RUW6
    • D6RUW8

    Protein attributes for MILR1 Gene

    Size:
    343 amino acids
    Molecular mass:
    38735 Da
    Quaternary structure:
    • Monomer. Interacts (tyrosine-phosphorylated) with PTPN6, PTPN11 and INPP5D.
    SequenceCaution:
    • Sequence=AAI36595.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAG62433.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for MILR1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MILR1 Gene

Proteomics data for MILR1 Gene at MOPED

Post-translational modifications for MILR1 Gene

No data available for DME Specific Peptides for MILR1 Gene

Domains & Families for MILR1 Gene

Gene Families for MILR1 Gene

Protein Domains for MILR1 Gene

Suggested Antigen Peptide Sequences for MILR1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7Z6M3

UniProtKB/Swiss-Prot:

MILR1_HUMAN :
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
Domain:
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
genes like me logo Genes that share domains with MILR1: view

Function for MILR1 Gene

Molecular function for MILR1 Gene

UniProtKB/Swiss-Prot Function:
Immunoglobulin-like receptor which plays an inhibitory role in degranulation of mast cells. Negatively regulates IgE-mediated mast cell activation and suppresses the type I immediate hypersensitivity reaction (By similarity).

Phenotypes for MILR1 Gene

genes like me logo Genes that share phenotypes with MILR1: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MILR1 Gene

Localization for MILR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MILR1 Gene

Cell membrane; Single-pass type I membrane protein.

No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MILR1 Gene

Pathways & Interactions for MILR1 Gene

SuperPathways for MILR1 Gene

No Data Available

Interacting Proteins for MILR1 Gene

Gene Ontology (GO) - Biological Process for MILR1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MILR1 Gene

Drugs & Compounds for MILR1 Gene

No Compound Related Data Available

Transcripts for MILR1 Gene

Unigene Clusters for MILR1 Gene

Mast cell immunoglobulin-like receptor 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MILR1 Gene

No ASD Table

Relevant External Links for MILR1 Gene

GeneLoc Exon Structure for
MILR1
ECgene alternative splicing isoforms for
MILR1

Expression for MILR1 Gene

mRNA expression in normal human tissues for MILR1 Gene

mRNA differential expression in normal tissues according to GTEx for MILR1 Gene

This gene is overexpressed in Whole Blood (x13.9) and Spleen (x4.7).

Protein differential expression in normal tissues from HIPED for MILR1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (51.4), Monocytes (9.5), and Adipocyte (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for MILR1 Gene



SOURCE GeneReport for Unigene cluster for MILR1 Gene Hs.631749

mRNA Expression by UniProt/SwissProt for MILR1 Gene

Q7Z6M3-MILR1_HUMAN
Tissue specificity: Expressed in myeloid cells (dendritic cells, macrophages and neutrophils, weak expression on B-cells but not in T-cells or natural killer cells), peripheral blood basophils and mast cells (at protein level).
genes like me logo Genes that share expression patterns with MILR1: view

Protein tissue co-expression partners for MILR1 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for MILR1 Gene

Orthologs for MILR1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MILR1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MILR1 35
  • 77.25 (n)
  • 62.91 (a)
MILR1 36
  • 14 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MILR1 35
  • 78.34 (n)
  • 63.8 (a)
MILR1 36
  • 15 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MILR1 35
  • 98.54 (n)
  • 97.08 (a)
MILR1 36
  • 22 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Milr1 36
  • 6 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MILR1 36
  • 3 (a)
OneToOne
chicken
(Gallus gallus)
Aves MILR1 35
  • 47.56 (n)
  • 36.18 (a)
MILR1 36
  • 2 (a)
OneToOne
Species with no ortholog for MILR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MILR1 Gene

ENSEMBL:
Gene Tree for MILR1 (if available)
TreeFam:
Gene Tree for MILR1 (if available)

Paralogs for MILR1 Gene

No data available for Paralogs for MILR1 Gene

Variants for MILR1 Gene

Sequence variations from dbSNP and Humsavar for MILR1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs4077660 -- 64,455,486(+) tcttg(C/T)tctgt intron-variant
rs6504230 -- 64,448,998(+) TCTTA(C/T)AGGAA intron-variant, upstream-variant-2KB
rs7211797 -- 64,452,178(+) agtga(C/T)cctcc intron-variant
rs7224553 -- 64,450,417(+) CCAAT(C/T)CTTCT intron-variant
rs7213455 -- 64,448,440(+) GTTTA(A/T)CAAAA intron-variant, upstream-variant-2KB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) , Variation tolerance and Relevant External Links for MILR1 Gene

Disorders for MILR1 Gene

Relevant External Links for MILR1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MILR1

No disorders were found for MILR1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MILR1 Gene

Publications for MILR1 Gene

  1. An immunoglobulin-like receptor, Allergin-1, inhibits immunoglobulin E-mediated immediate hypersensitivity reactions. (PMID: 20526344) Hitomi K. … Shibuya A. (Nat. Immunol. 2010) 2 3 4 67
  2. Influence of MILR1 promoter polymorphism on expression levels and the phenotype of atopy. (PMID: 25007884) Nanatsue K. … Noguchi E. (J. Hum. Genet. 2014) 3
  3. Expression and function of Allergin-1 on human primary mast cells. (PMID: 24116093) Nagai K. … Shibuya A. (PLoS ONE 2013) 3
  4. [Immunoglobulin-like receptor, allergin-1 regulates the activation of mast cells]. (PMID: 24552759) Tahara-Hanaoka S. … Shibuya A. (Arerugi 2013) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for MILR1 Gene

Sources for MILR1 Gene

Content