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MIIP Gene

protein-coding   GIFtS: 49
GCID: GC01P012079

Migration And Invasion Inhibitory Protein

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Migration And Invasion Inhibitory Protein1 2     Invasion Inhibitory Protein 451
Invasion-Inhibitory Protein 452 3     Migration And Invasion-Inhibitory Protein2
IIP452 3     IIp453
IGFBP2-Binding Protein2 3     

External Ids:    HGNC: 257151   Entrez Gene: 606722   Ensembl: ENSG000001166917   OMIM: 6087725   UniProtKB: Q5JXC23   
ORGUL members:         

Export aliases for MIIP gene to outside databases

Previous GC identifers: GC01P012004 GC01P011234


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MIIP Gene:
This gene encodes a protein that interacts with the oncogene protein insulin-like growth factor binding protein 2
and may function as an inhibitor of cell migration and invasion. This protein also interacts with the cell
division protein 20 and may be involved in regulating mitotic progression. This protein may function as a tumor
suppressor by inhibiting the growth or certain cancers. (provided by RefSeq, Sep 2011)

GeneCards Summary for MIIP Gene:
MIIP (migration and invasion inhibitory protein) is a protein-coding gene. Diseases associated with MIIP include breast cancer.

UniProtKB/Swiss-Prot: MIIP_HUMAN, Q5JXC2
Function: Inhibits glioma cells invasion and down-regulates adhesion- and motility-associated genes such as NFKB2
and ICAM1. Exhibits opposing effects to IGFBP2 on cell invasion




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MIIP gene promoter:
         Oct-B1   AP-2gamma   HNF-1A   C/EBPalpha   Evi-1   HEN1   HNF-1   AP-2beta   AP-2alpha   AP-2alphaA   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for MIIP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MIIP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.22   Ensembl cytogenetic band:  1p36.22   HGNC cytogenetic band: 1p36.22

MIIP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MIIP gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P012079:  view genomic region     (about GC identifiers)

Start:
12,079,512 bp from pter      End:
12,092,106 bp from pter
Size:
12,595 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MIIP_HUMAN, Q5JXC2 (See protein sequence)
Recommended Name: Migration and invasion-inhibitory protein  
Size: 388 amino acids; 42824 Da
Subunit: Interacts with IGFBP2
Secondary accessions: C0KL22 Q96HU6 Q9H839 Q9HA00
Alternative splicing: 2 isoforms:  Q5JXC2-1   Q5JXC2-2   

Explore the universe of human proteins at neXtProt for MIIP: NX_Q5JXC2

Explore proteomics data for MIIP at MOPED

Post-translational modifications: 

  • Isoform 2 is degraded by the ubiquitin-proteasome pathway1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MIIP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_068752.2  
    ENSEMBL proteins: 
     ENSP00000235332   ENSP00000392417  

    MIIP Human Recombinant Protein Products:

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    Novus Biologicals MIIP Protein
    Novus Biologicals MIIP Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for MIIP

    MIIP Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Abcam antibodies for MIIP
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    ThermoFisher Antibodies for MIIP
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    MIIP Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MIIP
    Cloud-Clone Corp. CLIAs for MIIP


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: Q5JXC2


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MIIP_HUMAN, Q5JXC2
    Function: Inhibits glioma cells invasion and down-regulates adhesion- and motility-associated genes such as NFKB2
    and ICAM1. Exhibits opposing effects to IGFBP2 on cell invasion
    Induction: Up-regulated by IGFBP2

    Phenotypes:
         2 GenomeRNAi human phenotypes for MIIP:

     Decreased homologous recombina  Increased cell number in G2M,  

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MIIP
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MIIP
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MIIP

    miRNA
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    Predesigned siRNA for gene silencing in human, mouse, rat MIIP

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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MIIP (NM_021933)
    Sino Biological Human cDNA Clone for MIIP
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MIIP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MIIP

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for MIIP 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MIIP


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus2
    cytosol1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MIIP
    Interactions:

        Search GeneGlobe Interaction Network for MIIP

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for MIIP (Q5JXC23 ENSP000002353324) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HDAC6Q9UBN73, ENSP000003340614I2D: score=1 STRING: ENSP00000334061
    CCNB1IP1ENSP000003373964STRING: ENSP00000337396
    PPP1CAENSP000003260314STRING: ENSP00000326031
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MIIP



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MIIP gene (2 alternative transcripts): 
    NM_021933.3  NM_001025374.1  

    Unigene Cluster for MIIP:

    Migration and invasion inhibitory protein
    Hs.8595  [show with all ESTs]
    Unigene Representative Sequence: NM_021933
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000478749 ENST00000235332(uc001ato.2) ENST00000466860 ENST00000498685
    ENST00000492256 ENST00000460823 ENST00000478299 ENST00000436478
    miRNA
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    Search for qRT-PCR Assays for microRNAs that regulate MIIP
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for MIIP
    Predesigned siRNA for gene silencing in human, mouse, rat MIIP
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    OriGene ORF clones in mouse, rat for MIIP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MIIP (NM_021933)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MIIP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MIIP
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for MIIP
    OriGene qSTAR qPCR primer pairs in human, mouse for MIIP
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MIIP
      QuantiTect SYBR Green Assays in human, mouse, rat MIIP
      QuantiFast Probe-based Assays in human, mouse, rat MIIP

    Additional mRNA sequence: 

    AK022500.1 AK024020.1 BC008068.2 FJ618905.1 

    11 DOTS entries:

    DT.113534  DT.95201067  DT.100829493  DT.121415358  DT.100823057  DT.100823064  DT.121415324  DT.92431786 
    DT.91677184  DT.95143564  DT.100823062 

    Selected AceView cDNA sequences (see all 248):

    CB266734 BQ053198 BM782791 CR610913 CR604336 BQ067861 AI863669 CA446531 
    BX336813 CF272255 BI917806 CR622933 BM887856 CA309020 BU684621 CR621410 
    AI568642 BM835418 BQ225309 T49282 BQ052413 AI918881 BM545037 AI962461 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MIIP (see all 11)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11a · 11b
    SP1:                                                                    -           -     -                                       
    SP2:              -                                                     -           -     -                                       
    SP3:              -     -                                               -           -     -                                       
    SP4:              -                                                     -                                                         
    SP5:                                                                    -                                                         


    ECgene alternative splicing isoforms for MIIP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MIIP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATGCGTGTA
    MIIP Expression
    About this image


    MIIP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Eye (Sensory Organs)
             Retina
     
     Testis (Reproductive System)
    MIIP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MIIP Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.8595

    UniProtKB/Swiss-Prot: MIIP_HUMAN, Q5JXC2
    Tissue specificity: Ubiquitous. Isoform 1 is expressed in brain but underexpressed in glioma tissues, at protein
    level. Isoform 2 is not detected in normal organs, but is expressed in gliomas with increasing levels with glioma
    progression. On the contrary, at protein level, isoform 2 is not detected in gliomas, suggesting that this
    isoform is unstable in glioma cells

        Custom PCR Arrays for MIIP
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MIIP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for MIIP gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Miip1 , 5 migration and invasion inhibitory protein1, 5 71.24(n)1
    61.71(a)1
      4 (78.56 cM)5
    280101  NM_001025365.21  NP_001020536.21 
     1478607785 
    chicken
    (Gallus gallus)
    Aves MIIP6
    migration and invasion inhibitory protein
    46(a)
    1 ↔ 1
    21(5491938-5499769)
    zebrafish
    (Danio rerio)
    Actinopterygii MIIP6
    migration and invasion inhibitory protein
    28(a)
    1 ↔ 1
    11(41981119-41995742) ENSDARG00000088346


    ENSEMBL Gene Tree for MIIP (if available)
    TreeFam Gene Tree for MIIP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MIIP (see all 453)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs355558031,2
    C--12078098(+) ATAAA-/TTTTTT 1 -- us2k10--------
    rs1899805211,2
    --12095616(+) AACTAA/CCTCTC 1 -- us2k10--------
    rs778358841,2
    C,F--12095680(+) GCCATC/TTTCTT 1 -- us2k11Minor allele frequency- T:0.04EA 120
    rs1475957061,2
    --12095691(+) GAGTCA/GGAGGG 1 -- us2k10--------
    rs1161666311,2
    F--12095757(+) GGGCTA/GCCTAT 1 -- us2k11Minor allele frequency- G:0.02WA 118
    rs1437808411,2
    --12095775(+) TCATT-/CTTTTT 1 -- us2k10--------
    rs1419446651,2
    C--12095868(+) CCTCCA/GCCTCC 1 -- us2k10--------
    rs1458092411,2
    --12095931(+) TATGCA/GCCACC 1 -- us2k10--------
    rs1821556581,2
    --12096039(+) ACCTCC/TCAAAG 1 -- us2k10--------
    rs1389270051,2
    C--12096104(+) AGAGAC/TGGGGT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for MIIP (12079512 - 12092106 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for MIIP:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv470693CNV Loss18288195
    nsv870502CNV Loss21882294
    nsv871917CNV Loss21882294

    Human Gene Mutation Database (HGMD): MIIP
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MIIP
    DNA2.0 Custom Variant and Variant Library Synthesis for MIIP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608772    OMIM disorders: --

    1 disease for MIIP:    
    About MalaCards
    breast cancer


    MIIP for disorders           About GeneDecksing

    Human Genome Epidemiology (HuGE) Navigator: MIIP (0 documents)

    Export disorders for MIIP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MIIP gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with MIIP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Inactivation of the invasion inhibitory gene IIp45 by alternative splicing in gliomas. (PubMed id 15867349)1, 2, 3, 9 Song S.W.... Zhang W. (Cancer Res. 2005)
    2. IIp45, an insulin-like growth factor binding protein 2 (IGFBP-2) binding protein, antagonizes IGFBP-2 stimulation of glioma cell invasion. (PubMed id 14617774)1, 2, 3 Song S.W.... Zhang W. (Proc. Natl. Acad. Sci. U.S.A. 2003)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Protein phosphatase 1I+ interacting proteins in the human brain. (PubMed id 22321011)1 Esteves S.L....da Cruz e Silva E.F. (OMICS 2012)
    5. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    6. Definition of a functional single nucleotide polymorphism in the cell migration inhibitory gene MIIP that affects the risk of breast cancer. (PubMed id 20103646)1 Song F....Chen K. (Cancer Res. 2010)
    7. IIp45 inhibits cell migration through inhibition of HDAC6. (PubMed id 20008322)1 Wu Y....Zhang W. (J. Biol. Chem. 2010)
    8. Inhibition of gliomagenesis and attenuation of mitotic transition by MIIP. (PubMed id 20418911)1 Ji P....Zhang W. (Oncogene 2010)
    9. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PubMed id 19773279)1 Hosgood H.D....Lan Q. (Occup Environ Med 2009)
    10. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 60672 HGNC: 25715 AceView: FLJ12438 Ensembl:ENSG00000116691 euGenes: HUgn60672
    ECgene: MIIP H-InvDB: MIIP

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MIIP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MIIP gene:
    Search GeneIP for patents involving MIIP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

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