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Aliases for MIIP Gene

Aliases for MIIP Gene

  • Migration And Invasion Inhibitory Protein 2 3
  • Invasion-Inhibitory Protein 45 3 4
  • IGFBP2-Binding Protein 3 4
  • IIP45 3 4
  • Migration And Invasion-Inhibitory Protein 3
  • Invasion Inhibitory Protein 45 2

External Ids for MIIP Gene

Previous GeneCards Identifiers for MIIP Gene

  • GC01P012004
  • GC01P012079
  • GC01P011234

Summaries for MIIP Gene

Entrez Gene Summary for MIIP Gene

  • This gene encodes a protein that interacts with the oncogene protein insulin-like growth factor binding protein 2 and may function as an inhibitor of cell migration and invasion. This protein also interacts with the cell division protein 20 and may be involved in regulating mitotic progression. This protein may function as a tumor suppressor by inhibiting the growth or certain cancers. [provided by RefSeq, Sep 2011]

GeneCards Summary for MIIP Gene

MIIP (Migration And Invasion Inhibitory Protein) is a Protein Coding gene.

UniProtKB/Swiss-Prot for MIIP Gene

  • Inhibits glioma cells invasion and down-regulates adhesion- and motility-associated genes such as NFKB2 and ICAM1. Exhibits opposing effects to IGFBP2 on cell invasion.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIIP Gene

Genomics for MIIP Gene

Regulatory Elements for MIIP Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MIIP Gene

12,019,242 bp from pter
12,032,049 bp from pter
12,808 bases
Plus strand

Genomic View for MIIP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIIP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIIP Gene

Proteins for MIIP Gene

  • Protein details for MIIP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Migration and invasion-inhibitory protein
    Protein Accession:
    Secondary Accessions:
    • C0KL22
    • Q96HU6
    • Q9H839
    • Q9HA00

    Protein attributes for MIIP Gene

    388 amino acids
    Molecular mass:
    42824 Da
    Quaternary structure:
    • Interacts with IGFBP2.

    Alternative splice isoforms for MIIP Gene


neXtProt entry for MIIP Gene

Proteomics data for MIIP Gene at MOPED

Post-translational modifications for MIIP Gene

  • Isoform 2 is degraded by the ubiquitin-proteasome pathway
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MIIP Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for MIIP Gene

Domains for MIIP Gene

Protein Domains for MIIP Gene


Suggested Antigen Peptide Sequences for MIIP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIIP: view

No data available for Gene Families and UniProtKB/Swiss-Prot for MIIP Gene

Function for MIIP Gene

Molecular function for MIIP Gene

UniProtKB/Swiss-Prot Function:
Inhibits glioma cells invasion and down-regulates adhesion- and motility-associated genes such as NFKB2 and ICAM1. Exhibits opposing effects to IGFBP2 on cell invasion.
UniProtKB/Swiss-Prot Induction:
Up-regulated by IGFBP2.

Gene Ontology (GO) - Molecular Function for MIIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with MIIP: view

Phenotypes for MIIP Gene

genes like me logo Genes that share phenotypes with MIIP: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MIIP

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MIIP Gene

Localization for MIIP Gene

Subcellular locations from

Jensen Localization Image for MIIP Gene COMPARTMENTS Subcellular localization image for MIIP gene
Compartment Confidence
nucleus 2
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for MIIP Gene

Pathways for MIIP Gene

SuperPathways for MIIP Gene

No Data Available

Interacting Proteins for MIIP Gene

Gene Ontology (GO) - Biological Process for MIIP Gene


No data available for Pathways by source for MIIP Gene

Transcripts for MIIP Gene

Unigene Clusters for MIIP Gene

Migration and invasion inhibitory protein:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MIIP

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIIP Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11a · 11b
SP1: - - -
SP2: - - - -
SP3: - - - - -
SP4: - -
SP5: -
SP6: -
SP7: - -
SP11: -

Relevant External Links for MIIP Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIIP Gene

mRNA expression in normal human tissues for MIIP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MIIP Gene

This gene is overexpressed in Whole Blood (6.2).

Protein differential expression in normal tissues for MIIP Gene

This gene is overexpressed in Frontal cortex (29.1), Fetal Brain (15.1), Placenta (14.5), and Fetal ovary (9.8).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for MIIP Gene

SOURCE GeneReport for Unigene cluster for MIIP Gene Hs.8595

mRNA Expression by UniProt/SwissProt for MIIP Gene

Tissue specificity: Ubiquitous. Isoform 1 is expressed in brain but underexpressed in glioma tissues, at protein level. Isoform 2 is not detected in normal organs, but is expressed in gliomas with increasing levels with glioma progression. On the contrary, at protein level, isoform 2 is not detected in gliomas, suggesting that this isoform is unstable in glioma cells.
genes like me logo Genes that share expressions with MIIP: view

Expression partners for MIIP Gene

In Situ Assay Products

Orthologs for MIIP Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIIP Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MIIP 35
  • 81.16 (n)
  • 72.55 (a)
  • 71 (a)
(Canis familiaris)
Mammalia MIIP 35
  • 76.72 (n)
  • 65.32 (a)
  • 62 (a)
(Mus musculus)
Mammalia Miip 35
  • 71.24 (n)
  • 61.71 (a)
Miip 16
Miip 36
  • 58 (a)
(Pan troglodytes)
Mammalia MIIP 35
  • 98.45 (n)
  • 97.16 (a)
IIP45 36
  • 97 (a)
(Rattus norvegicus)
Mammalia Miip 35
  • 70.4 (n)
  • 58.67 (a)
(Monodelphis domestica)
Mammalia MIIP 36
  • 41 (a)
(Ornithorhynchus anatinus)
Mammalia MIIP 36
  • 47 (a)
(Gallus gallus)
Aves MIIP 36
  • 46 (a)
(Danio rerio)
Actinopterygii MIIP 36
  • 28 (a)
Species with no ortholog for MIIP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIIP Gene

Gene Tree for MIIP (if available)
Gene Tree for MIIP (if available)

Paralogs for MIIP Gene

No data available for Paralogs for MIIP Gene

Variants for MIIP Gene

Sequence variations from dbSNP and Humsavar for MIIP Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs946461 -- 12,031,153(+) CTGCC(C/T)TGGTG intron-variant
rs1044117 -- 12,031,861(+) CCCCT(C/T)TGGCA utr-variant-3-prime, downstream-variant-500B
rs1044121 -- 12,031,971(+) CCAGA(A/G)AGGGA utr-variant-3-prime, downstream-variant-500B
rs1139720 -- 12,029,848(+) CACCG(A/C/T)GAGAC synonymous-codon, reference, stop-gained
rs1208989 -- 12,029,983(+) CCCAA(A/C)CGCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MIIP Gene

Variant ID Type Subtype PubMed ID
nsv870502 CNV Loss 21882294
nsv470693 CNV Loss 18288195
nsv871917 CNV Loss 21882294

Relevant External Links for MIIP Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MIIP Gene

Disorders for MIIP Gene

Relevant External Links for MIIP

Human Genome Epidemiology (HuGE) Navigator

No disorders were found for MIIP Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for MIIP Gene

Publications for MIIP Gene

  1. Inactivation of the invasion inhibitory gene IIp45 by alternative splicing in gliomas. (PMID: 15867349) Song S.W. … Zhang W. (Cancer Res. 2005) 2 3 4 23
  2. IIp45, an insulin-like growth factor binding protein 2 (IGFBP-2) binding protein, antagonizes IGFBP-2 stimulation of glioma cell invasion. (PMID: 14617774) Song S.W. … Zhang W. (Proc. Natl. Acad. Sci. U.S.A. 2003) 2 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3
  5. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PMID: 19773279) Hosgood H.D. … Lan Q. (Occup Environ Med 2009) 3

Products for MIIP Gene

Sources for MIIP Gene

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