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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MIIP Gene

protein-coding   GIFtS: 47
GCID: GC01P012079

Migration And Invasion Inhibitory Protein

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Migration And Invasion Inhibitory Protein1 2     Invasion Inhibitory Protein 451
Invasion-Inhibitory Protein 452 3     Migration And Invasion-Inhibitory Protein2
IIP452 3     IIp453
IGFBP2-Binding Protein2 3     

External Ids:    HGNC: 257151   Entrez Gene: 606722   Ensembl: ENSG000001166917   OMIM: 6087725   UniProtKB: Q5JXC23   

Export aliases for MIIP gene to outside databases

Previous GC identifers: GC01P012004 GC01P011234


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MIIP Gene:
This gene encodes a protein that interacts with the oncogene protein insulin-like growth factor binding protein 2
and may function as an inhibitor of cell migration and invasion. This protein also interacts with the cell
division protein 20 and may be involved in regulating mitotic progression. This protein may function as a tumor
suppressor by inhibiting the growth or certain cancers. (provided by RefSeq, Sep 2011)

GeneCards Summary for MIIP Gene: 
MIIP (migration and invasion inhibitory protein) is a protein-coding gene. Diseases associated with MIIP include breast cancer.

UniProtKB/Swiss-Prot: MIIP_HUMAN, Q5JXC2
Function: Inhibits glioma cells invasion and down-regulates adhesion- and motility-associated genes such as NFKB2
and ICAM1. Exhibits opposing effects to IGFBP2 on cell invasion




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_021937.19  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MIIP gene promoter:
         Oct-B1   AP-2gamma   HNF-1A   C/EBPalpha   Evi-1   HEN1   HNF-1   AP-2beta   AP-2alpha   AP-2alphaA   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for MIIP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MIIP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.22   Ensembl cytogenetic band:  1p36.22   HGNC cytogenetic band: 1p36.22

MIIP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MIIP gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P012079:  view genomic region     (about GC identifiers)

Start:
12,079,512 bp from pter      End:
12,092,106 bp from pter
Size:
12,595 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MIIP_HUMAN, Q5JXC2 (See protein sequence)
Recommended Name: Migration and invasion-inhibitory protein  
Size: 388 amino acids; 42824 Da
Subunit: Interacts with IGFBP2
Secondary accessions: C0KL22 Q96HU6 Q9H839 Q9HA00
Alternative splicing: 2 isoforms:  Q5JXC2-1   Q5JXC2-2   

Explore the universe of human proteins at neXtProt for MIIP: NX_Q5JXC2

Explore proteomics data for MIIP at MOPED 

Post-translational modifications:

  • UniProtKB: Isoform 2 is degraded by the ubiquitin-proteasome pathway
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q5JXC2

  • MIIP Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MIIP Protein Expression
    REFSEQ proteins: NP_068752.2  
    ENSEMBL proteins: 
     ENSP00000235332   ENSP00000392417  

    Human Recombinant Protein Products for MIIP: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q5JXC2


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MIIP_HUMAN, Q5JXC2
    Function: Inhibits glioma cells invasion and down-regulates adhesion- and motility-associated genes such as NFKB2
    and ICAM1. Exhibits opposing effects to IGFBP2 on cell invasion
    Induction: Up-regulated by IGFBP2

    Phenotypes:
         2 GenomeRNAi human phenotypes for MIIP:

     Decreased homologous recombina  Increased cell number in G2M,  

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for MIIP 
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MIIP


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MIIP

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for MIIP (Q5JXC23 ENSP000002353324) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HDAC6Q9UBN73, ENSP000003340614I2D: score=1 STRING: ENSP00000334061
    CCNB1IP1ENSP000003373964STRING: ENSP00000337396
    PPP1CAENSP000003260314STRING: ENSP00000326031
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MIIP

    Search CenterWatch for drugs/clinical trials and news about MIIP

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MIIP gene (2 alternative transcripts): 
    NM_021933.3  NM_001025374.1  

    Unigene Cluster for MIIP:

    Migration and invasion inhibitory protein
    Hs.8595  [show with all ESTs]
    Unigene Representative Sequence: NM_021933
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000478749 ENST00000235332(uc001ato.2) ENST00000466860 ENST00000498685
    ENST00000492256 ENST00000460823 ENST00000478299 ENST00000436478
    miRNA
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    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MIIP
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MIIP
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    GenScript: all cDNA clones in your preferred vector: MIIP (NM_021933)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MIIP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MIIP
    Sirion Biotech Customized lentivirus for stable overexpression of MIIP 
                         Customized lentivirus expression plasmids for stable overexpression of MIIP 
    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MIIP

    Additional mRNA sequence: 

    AK022500.1 AK024020.1 BC008068.2 FJ618905.1 

    11 DOTS entries:

    DT.113534  DT.95201067  DT.100829493  DT.121415358  DT.100823057  DT.100823064  DT.121415324  DT.92431786 
    DT.91677184  DT.95143564  DT.100823062 

    24/248 AceView cDNA sequences (see all 248):

    CR604336 AL558650 CK299947 BX427491 CR621410 BQ082397 AI381580 BM835418 
    BQ053198 AI962461 BU684621 AI636527 AI096944 BX336813 BM782791 CR592183 
    AK095928 BM543389 CR607498 BM887856 BM681208 AI918881 AI568642 CR603285 

    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for MIIP (see all 11)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11a · 11b
    SP1:                                                                    -           -     -                                       
    SP2:              -                                                     -           -     -                                       
    SP3:              -     -                                               -           -     -                                       
    SP4:              -                                                     -                                                         
    SP5:                                                                    -                                                         


    ECgene alternative splicing isoforms for MIIP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MIIP expression in normal human tissues (normalized intensities)      MIIP embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATGCGTGTA
    MIIP Expression
    About this image


    MIIP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Gut Tube (Gastrointestinal Tract)
             Definitive endoderm-like cells ( A scalable, suspension protocol for derivation of...
     
     Bone (Muscoskeletal System)
             bone marrow   
     
     Blood (Muscoskeletal System)
             bone marrow   
     
     Eye (Sensory Organs)
             retinal progenitor cell p0   
     
     Testis (Reproductive System)

    See MIIP Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MIIP

    SOURCE GeneReport for Unigene cluster: Hs.8595

    UniProtKB/Swiss-Prot: MIIP_HUMAN, Q5JXC2
    Tissue specificity: Ubiquitous. Isoform 1 is expressed in brain but underexpressed in glioma tissues, at protein
    level. Isoform 2 is not detected in normal organs, but is expressed in gliomas with increasing levels with glioma
    progression. On the contrary, at protein level, isoform 2 is not detected in gliomas, suggesting that this
    isoform is unstable in glioma cells

        SABiosciences Custom PCR Arrays for MIIP
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MIIP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for MIIP gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Miip1 , 5 migration and invasion inhibitory protein1, 5 72.96(n)1
    62.53(a)1
      4 (78.56 cM)5
    280101  NM_001025365.21  NP_001020536.21 
     1478607785 
    chicken
    (Gallus gallus)
    Aves MIIP1 migration and invasion inhibitory protein 49.36(n)
    41.72(a)
      419483  XM_417639.3  XP_417639.2 
    zebrafish
    (Danio rerio)
    Actinopterygii MIIP6
    migration and invasion inhibitory protein
    26(a)
    1 ↔ 1
    11(41981119-41995742)


    ENSEMBL Gene Tree for MIIP (if available)
    TreeFam Gene Tree for MIIP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/453 SNPs in MIIP are shown (see all 453)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs355558031,2
    C--12078098(+) ATAAA-/TTTTTT 1 -- us2k10--------
    rs1899805211,2
    --12095616(+) AACTAA/CCTCTC 1 -- us2k10--------
    rs778358841,2
    C,F--12095680(+) GCCATC/TTTCTT 1 -- us2k11Minor allele frequency- T:0.04EA 120
    rs1475957061,2
    --12095691(+) GAGTCA/GGAGGG 1 -- us2k10--------
    rs1161666311,2
    F--12095757(+) GGGCTA/GCCTAT 1 -- us2k11Minor allele frequency- G:0.02WA 118
    rs1437808411,2
    --12095775(+) TCATT-/CTTTTT 1 -- us2k10--------
    rs1419446651,2
    C--12095868(+) CCTCCA/GCCTCC 1 -- us2k10--------
    rs1458092411,2
    --12095931(+) TATGCA/GCCACC 1 -- us2k10--------
    rs1821556581,2
    --12096039(+) ACCTCC/TCAAAG 1 -- us2k10--------
    rs1389270051,2
    C--12096104(+) AGAGAC/TGGGGT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for MIIP (12079512 - 12092106 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for MIIP:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv470693CNV Loss18288195
    nsv870502CNV Loss21882294
    nsv871917CNV Loss21882294


    Human Gene Mutation Database (HGMD): MIIP
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608772    OMIM disorders: --

    2 diseases for MIIP:    About MalaCards
    breast cancer    


    MIIP for disorders           About GeneDecksing

    Human Genome Epidemiology (HuGE) Navigator: MIIP (0 documents)

    Export disorders for MIIP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MIIP gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with MIIP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Inactivation of the invasion inhibitory gene IIp45 by alternative splicing in gliomas. (PubMed id 15867349)1, 2, 3, 9 Song S.W.... Zhang W. (2005)
    2. IIp45, an insulin-like growth factor binding protein 2 (IGFBP-2) binding protein, antagonizes IGFBP-2 stimulation of glioma cell invasion. (PubMed id 14617774)1, 2, 3 Song S.W.... Zhang W. (2003)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Protein phosphatase 1a interacting proteins in the hum an brain. (PubMed id 22321011)1 Esteves S.L....da Cruz e Silva E.F. (2012)
    5. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
    6. Definition of a functional single nucleotide polymorp hism in the cell migration inhibitory gene MIIP that affects the risk of breast cancer. (PubMed id 20103646)1 Song F....Chen K. (2010)
    7. IIp45 inhibits cell migration through inhibition of H DAC6. (PubMed id 20008322)1 Wu Y....Zhang W. (2010)
    8. Inhibition of gliomagenesis and attenuation of mitoti c transition by MIIP. (PubMed id 20418911)1 Ji P....Zhang W. (2010)
    9. Association between genetic variants in VEGF, ERCC3 a nd occupational benzene haematotoxicity. (PubMed id 19773279)1 Hosgood H.D....Lan Q. (2009)
    10. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 60672 HGNC: 25715 AceView: FLJ12438 Ensembl:ENSG00000116691 euGenes: HUgn60672
    ECgene: MIIP H-InvDB: MIIP

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MIIP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MIIP gene:
    Search GeneIP for patents involving MIIP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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