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Aliases for MIIP Gene

Aliases for MIIP Gene

  • Migration And Invasion Inhibitory Protein 2 3 5
  • Invasion-Inhibitory Protein 45 3 4
  • IGFBP2-Binding Protein 3 4
  • IIP45 3 4
  • Invasion Inhibitory Protein 45 2

External Ids for MIIP Gene

Previous GeneCards Identifiers for MIIP Gene

  • GC01P012004
  • GC01P012079
  • GC01P011234

Summaries for MIIP Gene

Entrez Gene Summary for MIIP Gene

  • This gene encodes a protein that interacts with the oncogene protein insulin-like growth factor binding protein 2 and may function as an inhibitor of cell migration and invasion. This protein also interacts with the cell division protein 20 and may be involved in regulating mitotic progression. This protein may function as a tumor suppressor by inhibiting the growth or certain cancers. [provided by RefSeq, Sep 2011]

GeneCards Summary for MIIP Gene

MIIP (Migration And Invasion Inhibitory Protein) is a Protein Coding gene. Diseases associated with MIIP include Glioma.

UniProtKB/Swiss-Prot for MIIP Gene

  • Inhibits glioma cells invasion and down-regulates adhesion- and motility-associated genes such as NFKB2 and ICAM1. Exhibits opposing effects to IGFBP2 on cell invasion.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIIP Gene

Genomics for MIIP Gene

Regulatory Elements for MIIP Gene

Enhancers for MIIP Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MIIP on UCSC Golden Path with GeneCards custom track

Promoters for MIIP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MIIP on UCSC Golden Path with GeneCards custom track

Genomic Location for MIIP Gene

12,019,242 bp from pter
12,032,049 bp from pter
12,808 bases
Plus strand

Genomic View for MIIP Gene

Genes around MIIP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIIP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIIP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIIP Gene

Proteins for MIIP Gene

  • Protein details for MIIP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Migration and invasion-inhibitory protein
    Protein Accession:
    Secondary Accessions:
    • C0KL22
    • Q96HU6
    • Q9H839
    • Q9HA00

    Protein attributes for MIIP Gene

    388 amino acids
    Molecular mass:
    42824 Da
    Quaternary structure:
    • Interacts with IGFBP2.

    Alternative splice isoforms for MIIP Gene


neXtProt entry for MIIP Gene

Proteomics data for MIIP Gene at MOPED

Post-translational modifications for MIIP Gene

  • Isoform 2 is degraded by the ubiquitin-proteasome pathway.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MIIP Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MIIP Gene

Domains & Families for MIIP Gene

Protein Domains for MIIP Gene


Suggested Antigen Peptide Sequences for MIIP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIIP: view

No data available for Gene Families and UniProtKB/Swiss-Prot for MIIP Gene

Function for MIIP Gene

Molecular function for MIIP Gene

UniProtKB/Swiss-Prot Function:
Inhibits glioma cells invasion and down-regulates adhesion- and motility-associated genes such as NFKB2 and ICAM1. Exhibits opposing effects to IGFBP2 on cell invasion.
UniProtKB/Swiss-Prot Induction:
Up-regulated by IGFBP2.
genes like me logo Genes that share phenotypes with MIIP: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIIP Gene

Localization for MIIP Gene

Subcellular locations from

Jensen Localization Image for MIIP Gene COMPARTMENTS Subcellular localization image for MIIP gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for MIIP Gene

Pathways & Interactions for MIIP Gene

SuperPathways for MIIP Gene

No Data Available

Interacting Proteins for MIIP Gene

Gene Ontology (GO) - Biological Process for MIIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010972 negative regulation of G2/M transition of mitotic cell cycle IEA --
genes like me logo Genes that share ontologies with MIIP: view

No data available for Pathways by source and SIGNOR curated interactions for MIIP Gene

Drugs & Compounds for MIIP Gene

No Compound Related Data Available

Transcripts for MIIP Gene

Unigene Clusters for MIIP Gene

Migration and invasion inhibitory protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MIIP Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11a · 11b
SP1: - - -
SP2: - - - -
SP3: - - - - -
SP4: - -
SP5: -
SP6: -
SP7: - -
SP11: -

Relevant External Links for MIIP Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIIP Gene

mRNA expression in normal human tissues for MIIP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MIIP Gene

This gene is overexpressed in Whole Blood (x6.2).

Protein differential expression in normal tissues from HIPED for MIIP Gene

This gene is overexpressed in Frontal cortex (29.1), Fetal Brain (15.1), Placenta (14.5), and Fetal ovary (9.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MIIP Gene

SOURCE GeneReport for Unigene cluster for MIIP Gene Hs.8595

mRNA Expression by UniProt/SwissProt for MIIP Gene

Tissue specificity: Ubiquitous. Isoform 1 is expressed in brain but underexpressed in glioma tissues, at protein level. Isoform 2 is not detected in normal organs, but is expressed in gliomas with increasing levels with glioma progression. On the contrary, at protein level, isoform 2 is not detected in gliomas, suggesting that this isoform is unstable in glioma cells.
genes like me logo Genes that share expression patterns with MIIP: view

Protein tissue co-expression partners for MIIP Gene

Primer Products

Orthologs for MIIP Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIIP Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MIIP 35
  • 81.16 (n)
  • 72.55 (a)
  • 71 (a)
(Canis familiaris)
Mammalia MIIP 35
  • 76.72 (n)
  • 65.32 (a)
  • 62 (a)
(Mus musculus)
Mammalia Miip 35
  • 71.24 (n)
  • 61.71 (a)
Miip 16
Miip 36
  • 58 (a)
(Pan troglodytes)
Mammalia MIIP 35
  • 98.45 (n)
  • 97.16 (a)
IIP45 36
  • 97 (a)
(Rattus norvegicus)
Mammalia Miip 35
  • 70.4 (n)
  • 58.67 (a)
(Monodelphis domestica)
Mammalia MIIP 36
  • 41 (a)
(Ornithorhynchus anatinus)
Mammalia MIIP 36
  • 47 (a)
(Gallus gallus)
Aves MIIP 36
  • 46 (a)
(Danio rerio)
Actinopterygii MIIP 36
  • 28 (a)
Species with no ortholog for MIIP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIIP Gene

Gene Tree for MIIP (if available)
Gene Tree for MIIP (if available)

Paralogs for MIIP Gene

No data available for Paralogs for MIIP Gene

Variants for MIIP Gene

Sequence variations from dbSNP and Humsavar for MIIP Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs11553925 - 12,022,277(-) TGGCA(A/T)TTGGC reference, missense
rs11588712 - 12,022,404(+) AGACC(C/T)CGAGG reference, missense
rs2295283 - 12,022,869(+) TTCCT(A/G)AGAGG reference, missense
rs2295289 - 12,029,788(+) TCAAC(C/T)GGCGC reference, missense
rs35317667 - 12,030,045(+) GCTGT(C/T)GATCC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for MIIP Gene

Variant ID Type Subtype PubMed ID
nsv870502 CNV Loss 21882294
nsv470693 CNV Loss 18288195
nsv871917 CNV Loss 21882294

Variation tolerance for MIIP Gene

Residual Variation Intolerance Score: 93.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.88; 79.47% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MIIP Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MIIP Gene

Disorders for MIIP Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIIP Gene - From: GeneCards

Disorder Aliases PubMed IDs
- elite association - COSMIC cancer census association via MalaCards
Search MIIP in MalaCards View complete list of genes associated with diseases

Relevant External Links for MIIP

Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with MIIP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIIP Gene

Publications for MIIP Gene

  1. Inactivation of the invasion inhibitory gene IIp45 by alternative splicing in gliomas. (PMID: 15867349) Song S.W. … Zhang W. (Cancer Res. 2005) 2 3 4 23 67
  2. IIp45, an insulin-like growth factor binding protein 2 (IGFBP-2) binding protein, antagonizes IGFBP-2 stimulation of glioma cell invasion. (PMID: 14617774) Song S.W. … Zhang W. (Proc. Natl. Acad. Sci. U.S.A. 2003) 2 3
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  4. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3
  5. The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease. (PMID: 24705354) Butland S.L. … Hayden M.R. (Hum. Mol. Genet. 2014) 3

Products for MIIP Gene

Sources for MIIP Gene