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Aliases for MIGA2 Gene

Aliases for MIGA2 Gene

  • Mitoguardin 2 2 3 5
  • Family With Sequence Similarity 73, Member B 2 3
  • Protein FAM73B 3 4
  • C9orf54 3 4
  • FAM73B 3 4
  • Family With Sequence Similarity 73 Member B 2
  • Chromosome 9 Open Reading Frame 54 2
  • Mitoguardin-2 3

External Ids for MIGA2 Gene

Previous HGNC Symbols for MIGA2 Gene

  • C9orf54
  • FAM73B

Summaries for MIGA2 Gene

GeneCards Summary for MIGA2 Gene

MIGA2 (Mitoguardin 2) is a Protein Coding gene. An important paralog of this gene is MIGA1.

UniProtKB/Swiss-Prot for MIGA2 Gene

  • Regulator of mitochondrial fusion: acts by forming homo- and heterodimers at the mitochondrial outer membrane and facilitating the formation of PLD6/MitoPLD dimers. May act by regulating phospholipid metabolism via PLD6/MitoPLD.

Gene Wiki entry for MIGA2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIGA2 Gene

Genomics for MIGA2 Gene

Regulatory Elements for MIGA2 Gene

Enhancers for MIGA2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09G129067 1.6 Ensembl ENCODE dbSUPER 12.7 +33.5 33487 5.2 HDGF PKNOX1 CREB3L1 ARNT YY1 ZNF766 CBX5 FOS REST ZNF592 CRAT ENSG00000234055 MIGA2 URM1 SPOUT1 DOLPP1
GH09G129035 1.1 ENCODE 10.4 +0.7 689 2.9 HDGF PKNOX1 ZFP64 ARID4B SIN3A FEZF1 ZNF2 ZBTB7B YY1 SLC30A9 ENSG00000272593 SPTAN1 LOC105376289 ENSG00000272696 LOC101929314 C9orf50 MIGA2 LOC100506100 ZDHHC12 PKN3
GH09G129064 0.9 ENCODE 12.7 +28.1 28137 0.4 FOXA2 MLX ARID4B DMAP1 ZNF48 YY1 TCF12 ZHX2 NFYC MIER2 CRAT ENSG00000234055 MIGA2 DOLPP1
GH09G129380 1.7 FANTOM5 Ensembl ENCODE dbSUPER 2.8 +346.2 346161 4.6 PKNOX1 PTBP1 RAD21 ZBTB7B GLIS2 RCOR1 FOS CEBPB ZHX2 GATAD2B NTMT1 C9orf50 ENDOG GLE1 USP20 C9orf106 C9orf78 MIGA2 TOR1B ASB6
GH09G129031 0.4 ENCODE 10.6 -4.9 -4889 0.2 ZNF362 SP2 MIGA2 SH3GLB2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIGA2 on UCSC Golden Path with GeneCards custom track

Promoters for MIGA2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000241940 95 1401 HDGF PKNOX1 ZFP64 ARID4B SIN3A FEZF1 ZNF2 ZBTB7B YY1 SLC30A9

Genomic Location for MIGA2 Gene

Chromosome:
9
Start:
129,036,605 bp from pter
End:
129,072,082 bp from pter
Size:
35,478 bases
Orientation:
Plus strand

Genomic View for MIGA2 Gene

Genes around MIGA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIGA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIGA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIGA2 Gene

Proteins for MIGA2 Gene

  • Protein details for MIGA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7L4E1-MIGA2_HUMAN
    Recommended name:
    Mitoguardin 2
    Protein Accession:
    Q7L4E1
    Secondary Accessions:
    • Q8NBM3
    • Q8TEJ6
    • Q969E6

    Protein attributes for MIGA2 Gene

    Size:
    593 amino acids
    Molecular mass:
    65531 Da
    Quaternary structure:
    • Homodimer and heterodimer; forms heterodimers with MIGA1 (PubMed:26711011). Interacts with PLD6/MitoPLD (PubMed:26711011).
    SequenceCaution:
    • Sequence=BAB55159.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB84953.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=EAW87861.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for MIGA2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MIGA2 Gene

Post-translational modifications for MIGA2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MIGA2 Gene

Domains & Families for MIGA2 Gene

Protein Domains for MIGA2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MIGA2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7L4E1

UniProtKB/Swiss-Prot:

MIGA2_HUMAN :
  • Belongs to the mitoguardin family.
Family:
  • Belongs to the mitoguardin family.
genes like me logo Genes that share domains with MIGA2: view

No data available for Gene Families for MIGA2 Gene

Function for MIGA2 Gene

Molecular function for MIGA2 Gene

UniProtKB/Swiss-Prot Function:
Regulator of mitochondrial fusion: acts by forming homo- and heterodimers at the mitochondrial outer membrane and facilitating the formation of PLD6/MitoPLD dimers. May act by regulating phospholipid metabolism via PLD6/MitoPLD.

Gene Ontology (GO) - Molecular Function for MIGA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 26711011
GO:0042803 protein homodimerization activity IDA 26711011
GO:0046982 protein heterodimerization activity IDA 26711011
genes like me logo Genes that share ontologies with MIGA2: view
genes like me logo Genes that share phenotypes with MIGA2: view

Animal Models for MIGA2 Gene

MGI Knock Outs for MIGA2:

Animal Model Products

CRISPR Products

miRNA for MIGA2 Gene

miRTarBase miRNAs that target MIGA2

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MIGA2 Gene

Localization for MIGA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIGA2 Gene

Mitochondrion outer membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIGA2 gene
Compartment Confidence
mitochondrion 3
plasma membrane 2
endoplasmic reticulum 2
cytosol 2
extracellular 1
peroxisome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for MIGA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005741 mitochondrial outer membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0045203 integral component of cell outer membrane IDA 26711011
genes like me logo Genes that share ontologies with MIGA2: view

Pathways & Interactions for MIGA2 Gene

SuperPathways for MIGA2 Gene

No Data Available

Interacting Proteins for MIGA2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000351138%0d%0a9606.ENSP00000417175%0d%0a
Selected Interacting proteins: ENSP00000351138 Q7L4E1-MIGA2_HUMAN for MIGA2 Gene via STRING IID

Gene Ontology (GO) - Biological Process for MIGA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008053 mitochondrial fusion IDA,IEA 26711011
GO:0060348 bone development IEA --
genes like me logo Genes that share ontologies with MIGA2: view

No data available for Pathways by source and SIGNOR curated interactions for MIGA2 Gene

Drugs & Compounds for MIGA2 Gene

No Compound Related Data Available

Transcripts for MIGA2 Gene

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIGA2 Gene

No ASD Table

Relevant External Links for MIGA2 Gene

GeneLoc Exon Structure for
MIGA2
ECgene alternative splicing isoforms for
MIGA2

Expression for MIGA2 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIGA2 Gene:

MIGA2

Evidence on tissue expression from TISSUES for MIGA2 Gene

  • Nervous system(4.9)
  • Spleen(4.2)
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIGA2 Gene

Orthologs for MIGA2 Gene

This gene was present in the common ancestor of animals.

Orthologs for MIGA2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM73B 35 34
  • 99.38 (n)
OneToOne
cow
(Bos Taurus)
Mammalia FAM73B 35 34
  • 90.67 (n)
OneToOne
dog
(Canis familiaris)
Mammalia FAM73B 35 34
  • 89.09 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Fam73b 35 34
  • 86.68 (n)
OneToOne
Miga2 16
rat
(Rattus norvegicus)
Mammalia Fam73b 34
  • 86.04 (n)
oppossum
(Monodelphis domestica)
Mammalia FAM73B 35
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 72 (a)
OneToMany
-- 35
  • 72 (a)
OneToMany
chicken
(Gallus gallus)
Aves FAM73B 35 34
  • 74.48 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM73B 35
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam73b 34
  • 66.37 (n)
Str.11456 34
zebrafish
(Danio rerio)
Actinopterygii fam73b 35 34
  • 62.9 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011689 34
  • 52.97 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG12125 34 35
  • 49.81 (n)
worm
(Caenorhabditis elegans)
Secernentea K01D12.6 35
  • 26 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 46 (a)
OneToMany
Species where no ortholog for MIGA2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MIGA2 Gene

ENSEMBL:
Gene Tree for MIGA2 (if available)
TreeFam:
Gene Tree for MIGA2 (if available)

Paralogs for MIGA2 Gene

Paralogs for MIGA2 Gene

genes like me logo Genes that share paralogs with MIGA2: view

Variants for MIGA2 Gene

Sequence variations from dbSNP and Humsavar for MIGA2 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1000019761 -- 129,042,852(+) AGCCA(C/G/T)GTGGT intron-variant
rs1000086655 -- 129,036,641(+) CCGCC(A/G)GGGAA nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000206416 -- 129,049,005(+) CCACT(C/T)GTGTG intron-variant
rs1000326455 -- 129,056,570(+) CTGAA(-/G)TGCAG intron-variant
rs1000366260 -- 129,044,843(+) GCCTT(C/G)GCCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MIGA2 Gene

Variant ID Type Subtype PubMed ID
esv2665493 CNV deletion 23128226
esv3621823 CNV loss 21293372
nsv509323 CNV insertion 20534489
nsv818725 CNV gain 17921354
nsv831729 CNV loss 17160897

Variation tolerance for MIGA2 Gene

Residual Variation Intolerance Score: 40.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.99; 84.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MIGA2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIGA2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MIGA2 Gene

Disorders for MIGA2 Gene

Relevant External Links for MIGA2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIGA2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIGA2

No disorders were found for MIGA2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIGA2 Gene

Publications for MIGA2 Gene

  1. Mitoguardin-1 and -2 promote maturation and the developmental potential of mouse oocytes by maintaining mitochondrial dynamics and functions. (PMID: 26716412) Liu X.M. … Fan H.Y. (Oncotarget 2016) 2 3 64
  2. Mitoguardin regulates mitochondrial fusion through MitoPLD and is required for neuronal homeostasis. (PMID: 26711011) Zhang Y. … Tong C. (Mol. Cell 2016) 3 4 64
  3. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for MIGA2 Gene

Sources for MIGA2 Gene

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