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Aliases for MIGA1 Gene

Aliases for MIGA1 Gene

  • Mitoguardin 1 2 3 5
  • Protein FAM73A 3 4
  • FAM73A 3 4
  • Family With Sequence Similarity 73, Member A 3
  • Family With Sequence Similarity 73 Member A 2

External Ids for MIGA1 Gene

Previous HGNC Symbols for MIGA1 Gene

  • FAM73A

Summaries for MIGA1 Gene

GeneCards Summary for MIGA1 Gene

MIGA1 (Mitoguardin 1) is a Protein Coding gene. An important paralog of this gene is MIGA2.

UniProtKB/Swiss-Prot for MIGA1 Gene

  • Regulator of mitochondrial fusion: acts by forming homo- and heterodimers at the mitochondrial outer membrane and facilitating the formation of PLD6/MitoPLD dimers. May act by regulating phospholipid metabolism via PLD6/MitoPLD.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIGA1 Gene

Genomics for MIGA1 Gene

Regulatory Elements for MIGA1 Gene

Enhancers for MIGA1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F077829 1 Ensembl ENCODE 10.8 +52.9 52919 6.5 SIN3A GATA3 PRDM10 NFE2 MAFK EZH2 TCF7L2 NFE2L2 RFX1 NR2F2 RNA5SP21 MIGA1 ACTG1P21 USP33 IFI44 NEXN FUBP1 NSRP1P1 LOC653631
GH01F077823 0.9 Ensembl ENCODE 11.5 +45.4 45395 2.4 SCRT1 CTCF HLF JUN BHLHE40 CEBPB RAD21 JUND SCRT2 MYNN MIGA1 RNA5SP21 ACTG1P21 LOC653631 NSRP1P1
GH01F078070 0.9 Ensembl ENCODE 9.4 +291.7 291727 2.1 PKNOX1 JUN CEBPB JUNB FEZF1 YY1 JUND ATF3 ZNF512 FOS GIPC2 ACTG1P21 MIGA1 RNA5SP21 IFI44 RNU6-1102P LOC100131495
GH01F077686 0.8 Ensembl ENCODE 10.4 -92.1 -92140 1.4 ZNF263 CTCF POLR2A ZBTB33 RAD21 ACTG1P21 MIGA1 RNA5SP21 AK5 GIPC2 ZZZ3 USP33
GH01F077900 0.6 ENCODE 10.5 +121.2 121249 0.2 CTCF ZNF654 SMC3 REST RAD21 RFX5 ACTG1P21 MIGA1 RNA5SP21 ZZZ3 NEXN-AS1 DNAJB4
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIGA1 on UCSC Golden Path with GeneCards custom track

Promoters for MIGA1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000539315 279 1800 HDGF PKNOX1 ATF1 ARID4B SIN3A FEZF1 GLI4 DMAP1 ZNF48 ZNF2

Genomic Location for MIGA1 Gene

Chromosome:
1
Start:
77,779,622 bp from pter
End:
77,879,540 bp from pter
Size:
99,919 bases
Orientation:
Plus strand

Genomic View for MIGA1 Gene

Genes around MIGA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIGA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIGA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIGA1 Gene

Proteins for MIGA1 Gene

  • Protein details for MIGA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NAN2-MIGA1_HUMAN
    Recommended name:
    Mitoguardin 1
    Protein Accession:
    Q8NAN2
    Secondary Accessions:
    • Q6MZG0

    Protein attributes for MIGA1 Gene

    Size:
    632 amino acids
    Molecular mass:
    71006 Da
    Quaternary structure:
    • Homodimer and heterodimer; forms heterodimers with MIGA2 (PubMed:26711011). Interacts with PLD6/MitoPLD (PubMed:26711011).

    Alternative splice isoforms for MIGA1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MIGA1 Gene

Post-translational modifications for MIGA1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MIGA1 Gene

Domains & Families for MIGA1 Gene

Protein Domains for MIGA1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MIGA1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NAN2

UniProtKB/Swiss-Prot:

MIGA1_HUMAN :
  • Belongs to the mitoguardin family.
Family:
  • Belongs to the mitoguardin family.
genes like me logo Genes that share domains with MIGA1: view

No data available for Gene Families for MIGA1 Gene

Function for MIGA1 Gene

Molecular function for MIGA1 Gene

UniProtKB/Swiss-Prot Function:
Regulator of mitochondrial fusion: acts by forming homo- and heterodimers at the mitochondrial outer membrane and facilitating the formation of PLD6/MitoPLD dimers. May act by regulating phospholipid metabolism via PLD6/MitoPLD.

Gene Ontology (GO) - Molecular Function for MIGA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 26711011
GO:0042803 protein homodimerization activity IDA 26711011
GO:0046982 protein heterodimerization activity IDA 26711011
genes like me logo Genes that share ontologies with MIGA1: view
genes like me logo Genes that share phenotypes with MIGA1: view

Animal Models for MIGA1 Gene

MGI Knock Outs for MIGA1:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MIGA1 Gene

Localization for MIGA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIGA1 Gene

Mitochondrion outer membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIGA1 gene
Compartment Confidence
mitochondrion 4
nucleus 2
cytosol 2
plasma membrane 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for MIGA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005741 mitochondrial outer membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0045203 integral component of cell outer membrane IDA 26711011
genes like me logo Genes that share ontologies with MIGA1: view

Pathways & Interactions for MIGA1 Gene

SuperPathways for MIGA1 Gene

No Data Available

Interacting Proteins for MIGA1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000359827%0d%0a9606.ENSP00000385269%0d%0a
Selected Interacting proteins: Q8NAN2-MIGA1_HUMAN ENSP00000359827 for MIGA1 Gene via IID STRING

Gene Ontology (GO) - Biological Process for MIGA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008053 mitochondrial fusion IEA,IDA 26711011
genes like me logo Genes that share ontologies with MIGA1: view

No data available for Pathways by source and SIGNOR curated interactions for MIGA1 Gene

Transcripts for MIGA1 Gene

Unigene Clusters for MIGA1 Gene

Family with sequence similarity 73, member A:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIGA1 Gene

No ASD Table

Relevant External Links for MIGA1 Gene

GeneLoc Exon Structure for
MIGA1
ECgene alternative splicing isoforms for
MIGA1

Expression for MIGA1 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIGA1 Gene:

MIGA1

SOURCE GeneReport for Unigene cluster for MIGA1 Gene:

Hs.437755
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIGA1 Gene

Orthologs for MIGA1 Gene

This gene was present in the common ancestor of animals.

Orthologs for MIGA1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM73A 34 35
  • 99.58 (n)
dog
(Canis familiaris)
Mammalia FAM73A 34 35
  • 92.57 (n)
cow
(Bos Taurus)
Mammalia FAM73A 34 35
  • 92.22 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia FAM73A 35
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fam73a 34 35
  • 84.06 (n)
Miga1 16
rat
(Rattus norvegicus)
Mammalia Fam73a 34
  • 81.13 (n)
oppossum
(Monodelphis domestica)
Mammalia FAM73A 35
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM73A 34 35
  • 80.3 (n)
lizard
(Anolis carolinensis)
Reptilia FAM73A 35
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam73a 34
  • 69.38 (n)
zebrafish
(Danio rerio)
Actinopterygii fam73a 34 35
  • 63.32 (n)
Dr.18613 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1985 34
fruit fly
(Drosophila melanogaster)
Insecta CG12125 35
  • 27 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea K01D12.6 35
  • 26 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 42 (a)
OneToMany
Species where no ortholog for MIGA1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MIGA1 Gene

ENSEMBL:
Gene Tree for MIGA1 (if available)
TreeFam:
Gene Tree for MIGA1 (if available)

Paralogs for MIGA1 Gene

Paralogs for MIGA1 Gene

genes like me logo Genes that share paralogs with MIGA1: view

Variants for MIGA1 Gene

Sequence variations from dbSNP and Humsavar for MIGA1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1047939 -- 77,879,246(+) ATGTA(A/T)GTGAA nc-transcript-variant, utr-variant-3-prime
rs10518561 -- 77,822,630(+) ACTTG(C/T)AAATC intron-variant
rs10676009 -- 77,817,975(+) TTTTT(-/T/TT)GCAGC intron-variant
rs10782656 -- 77,852,032(+) GGCAT(C/G)TGCCA intron-variant
rs10873954 -- 77,818,344(+) TCTCG(A/G)ACTCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MIGA1 Gene

Variant ID Type Subtype PubMed ID
nsv947433 CNV duplication 23825009
nsv946007 CNV duplication 23825009
nsv946006 CNV duplication 23825009
nsv830303 CNV loss 17160897
nsv546591 CNV gain 21841781
nsv470719 CNV gain 18288195
esv3586530 CNV loss 21293372
esv2674622 CNV deletion 23128226

Variation tolerance for MIGA1 Gene

Residual Variation Intolerance Score: 17.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.15; 23.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MIGA1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIGA1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MIGA1 Gene

Disorders for MIGA1 Gene

Relevant External Links for MIGA1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIGA1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIGA1

No disorders were found for MIGA1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIGA1 Gene

Publications for MIGA1 Gene

  1. Mitoguardin-1 and -2 promote maturation and the developmental potential of mouse oocytes by maintaining mitochondrial dynamics and functions. (PMID: 26716412) Liu X.M. … Fan H.Y. (Oncotarget 2016) 2 3 64
  2. Mitoguardin regulates mitochondrial fusion through MitoPLD and is required for neuronal homeostasis. (PMID: 26711011) Zhang Y. … Tong C. (Mol. Cell 2016) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64

Products for MIGA1 Gene

Sources for MIGA1 Gene

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