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Aliases for MIF4GD Gene

Aliases for MIF4GD Gene

  • MIF4G Domain Containing 2 3 5
  • SLBP-Interacting Protein 1 2 3 4
  • SLIP1 3 4
  • SLBP (Stem Loop Binding Protein)-Interacting Protein 1 3
  • MIF4G Domain-Containing Protein 3
  • HSLIP1 4
  • AD023 3
  • MIFD 3

External Ids for MIF4GD Gene

Previous HGNC Symbols for MIF4GD Gene

  • MIFD

Previous GeneCards Identifiers for MIF4GD Gene

  • GC17M070774
  • GC17M073262
  • GC17M068672

Summaries for MIF4GD Gene

Entrez Gene Summary for MIF4GD Gene

  • This gene encodes a protein which interacts with the N-terminus of the stem-loop binding protein (SLBP) and the 3' end of histone mRNA. This interaction facilitates the activation of histone mRNA translation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011]

GeneCards Summary for MIF4GD Gene

MIF4GD (MIF4G Domain Containing) is a Protein Coding gene. GO annotations related to this gene include RNA binding and protein C-terminus binding. An important paralog of this gene is CTIF.

UniProtKB/Swiss-Prot for MIF4GD Gene

  • Functions in replication-dependent translation of histone mRNAs which differ from other eukaryotic mRNAs in that they do not end with a poly-A tail but a stem-loop. May participate in circularizing those mRNAs specifically enhancing their translation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIF4GD Gene

Genomics for MIF4GD Gene

Regulatory Elements for MIF4GD Gene

Enhancers for MIF4GD Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F075260 0.5 ENCODE 11.3 +9.5 9493 3.0 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ZFP64 SIN3A DMAP1 ZNF2 YY1 NUP85 UNK MRPS7 NT5C H3F3B ENSG00000266980 HID1-AS1 CASKIN2 ENSG00000267801 MIF4GD
GH17F075265 0.5 ENCODE 11.1 +4.4 4401 3.1 ATF1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF48 YY1 SLC30A9 GATA2 NUP85 MIF4GD MRPS7 PIR61576
GH17F075180 0.2 ENCODE 11 +88.6 88643 3.3 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 YY1 ZNF207 FOS NUP85 ATP5H SUMO2 NT5C ENSG00000267342 MIF4GD KCTD2 CDR2L TRIM65 HN1
GH17F075410 1 Ensembl ENCODE 11 -140.8 -140799 2.2 HDGF PKNOX1 WRNIP1 ARID4B YBX1 ZNF48 ZNF2 ZNF121 SLC30A9 ZNF143 NUP85 ENSG00000266980 LOC101928343 LLGL2 MIR6785 TMEM94 NT5C MIF4GD ENSG00000267342 SPHK1
GH17F075085 1.3 FANTOM5 Ensembl ENCODE 10.9 +179.8 179797 11.9 MLX CREB3L1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 MCM3 SP3 ENSG00000264829 MGC16275 SLC16A5 CDR2L ENSG00000267342 MIF4GD NAT9 MRPS7 MRPL58 MYO15B
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIF4GD on UCSC Golden Path with GeneCards custom track

Promoters for MIF4GD Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001353274 92 2001 CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207 ZNF143 SP3

Genomic Location for MIF4GD Gene

Chromosome:
17
Start:
75,266,228 bp from pter
End:
75,271,292 bp from pter
Size:
5,065 bases
Orientation:
Minus strand

Genomic View for MIF4GD Gene

Genes around MIF4GD on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIF4GD Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIF4GD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIF4GD Gene

Proteins for MIF4GD Gene

  • Protein details for MIF4GD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A9UHW6-MI4GD_HUMAN
    Recommended name:
    MIF4G domain-containing protein
    Protein Accession:
    A9UHW6
    Secondary Accessions:
    • B4DUM7
    • Q8N4Q5
    • Q9HBL5

    Protein attributes for MIF4GD Gene

    Size:
    222 amino acids
    Molecular mass:
    25423 Da
    Quaternary structure:
    • Interacts with EIF4G1, EIF4G2 and SLBP; probably tethered by SLBP to the 3-end of mRNAs ending with the histone stem-loop, it also interacts with EIF4G1 which is bound to their 5-end.
    Miscellaneous:
    • Depletion of MIF4GD results in cell death and reduced histone mRNA translation.
    SequenceCaution:
    • Sequence=AAG09724.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};

    Alternative splice isoforms for MIF4GD Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MIF4GD Gene

Post-translational modifications for MIF4GD Gene

  • Ubiquitination at Lys 53 and Lys 68
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for MIF4GD Gene

Domains & Families for MIF4GD Gene

Protein Domains for MIF4GD Gene

Suggested Antigen Peptide Sequences for MIF4GD Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A9UHW6

UniProtKB/Swiss-Prot:

MI4GD_HUMAN :
  • Contains 1 MIF4G domain.
  • Belongs to the MIF4GD family.
Domain:
  • Contains 1 MIF4G domain.
Family:
  • Belongs to the MIF4GD family.
genes like me logo Genes that share domains with MIF4GD: view

No data available for Gene Families for MIF4GD Gene

Function for MIF4GD Gene

Molecular function for MIF4GD Gene

UniProtKB/Swiss-Prot Function:
Functions in replication-dependent translation of histone mRNAs which differ from other eukaryotic mRNAs in that they do not end with a poly-A tail but a stem-loop. May participate in circularizing those mRNAs specifically enhancing their translation.

Gene Ontology (GO) - Molecular Function for MIF4GD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
GO:0005515 protein binding IPI 16189514
GO:0008022 protein C-terminus binding IPI 17577209
genes like me logo Genes that share ontologies with MIF4GD: view
genes like me logo Genes that share phenotypes with MIF4GD: view

Animal Model Products

miRNA for MIF4GD Gene

miRTarBase miRNAs that target MIF4GD

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MIF4GD Gene

Localization for MIF4GD Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIF4GD Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MIF4GD Gene COMPARTMENTS Subcellular localization image for MIF4GD gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 2
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for MIF4GD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IEA,IDA --
genes like me logo Genes that share ontologies with MIF4GD: view

Pathways & Interactions for MIF4GD Gene

SuperPathways for MIF4GD Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIF4GD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006417 regulation of translation IEA --
genes like me logo Genes that share ontologies with MIF4GD: view

No data available for Pathways by source and SIGNOR curated interactions for MIF4GD Gene

Transcripts for MIF4GD Gene

Unigene Clusters for MIF4GD Gene

MIF4G domain containing:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIF4GD Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c · 3d · 3e ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c · 8d · 8e
SP1: - - - -
SP2: - - -
SP3: - - - - - -
SP4: - - -
SP5: - - - - - - - -
SP6: - - - -
SP7: - - -
SP8: - - - -
SP9: - - - -
SP10:
SP11: - -

Relevant External Links for MIF4GD Gene

GeneLoc Exon Structure for
MIF4GD
ECgene alternative splicing isoforms for
MIF4GD

Expression for MIF4GD Gene

mRNA expression in normal human tissues for MIF4GD Gene

Protein differential expression in normal tissues from HIPED for MIF4GD Gene

This gene is overexpressed in Peripheral blood mononuclear cells (21.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MIF4GD Gene



Protein tissue co-expression partners for MIF4GD Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MIF4GD Gene:

MIF4GD

SOURCE GeneReport for Unigene cluster for MIF4GD Gene:

Hs.325631
genes like me logo Genes that share expression patterns with MIF4GD: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MIF4GD Gene

Orthologs for MIF4GD Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIF4GD Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MIF4GD 34 35
  • 99.87 (n)
dog
(Canis familiaris)
Mammalia -- 35
  • 98 (a)
OneToMany
MIF4GD 34
  • 92.94 (n)
-- 35
  • 61 (a)
OneToMany
cow
(Bos Taurus)
Mammalia MIF4GD 34 35
  • 94.44 (n)
mouse
(Mus musculus)
Mammalia Mif4gd 34 16 35
  • 91.29 (n)
rat
(Rattus norvegicus)
Mammalia Mif4gd 34
  • 91.29 (n)
oppossum
(Monodelphis domestica)
Mammalia MIF4GD 35
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MIF4GD 35
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves MIF4GD 34 35
  • 78.68 (n)
lizard
(Anolis carolinensis)
Reptilia MIF4GD 35
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mif4gd 34
  • 72.96 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC53513 34
zebrafish
(Danio rerio)
Actinopterygii mif4gdb 34 35
  • 72.07 (n)
mif4gda 35
  • 66 (a)
OneToMany
zgc64152 34
Species where no ortholog for MIF4GD was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIF4GD Gene

ENSEMBL:
Gene Tree for MIF4GD (if available)
TreeFam:
Gene Tree for MIF4GD (if available)

Paralogs for MIF4GD Gene

Paralogs for MIF4GD Gene

genes like me logo Genes that share paralogs with MIF4GD: view

Variants for MIF4GD Gene

Sequence variations from dbSNP and Humsavar for MIF4GD Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs112006920 -- 75,270,317(+) CCTGG(A/C)CGGGG intron-variant, upstream-variant-2KB
rs112122132 -- 75,266,796(+) CCAGC(C/T)GGCCG downstream-variant-500B, reference, missense, utr-variant-3-prime
rs112390467 -- 75,269,911(+) TACAG(C/T)CTGAG intron-variant, upstream-variant-2KB
rs112476728 -- 75,267,199(+) TTCTT(A/C)ATCCC intron-variant, utr-variant-3-prime
rs112577980 -- 75,267,908(+) TGTGA(A/G)CCAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MIF4GD Gene

Variant ID Type Subtype PubMed ID
nsv1066312 CNV gain 25217958
nsv510727 CNV deletion 20534489
nsv576027 CNV gain 21841781

Variation tolerance for MIF4GD Gene

Residual Variation Intolerance Score: 18.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.16; 75.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MIF4GD Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIF4GD

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MIF4GD Gene

Disorders for MIF4GD Gene

Relevant External Links for MIF4GD

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIF4GD

No disorders were found for MIF4GD Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIF4GD Gene

Publications for MIF4GD Gene

  1. SLIP1, a factor required for activation of histone mRNA translation by the stem-loop binding protein. (PMID: 18025107) Cakmakci N.G. … Marzluff W.F. (Mol. Cell. Biol. 2008) 2 3 4 64
  2. INT6 interacts with MIF4GD/SLIP1 and is necessary for efficient histone mRNA translation. (PMID: 22532700) Neusiedler J. … Jalinot P. (RNA 2012) 2 3 64
  3. Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. (PMID: 26871637) Yang X. … Vidal M. (Cell 2016) 3 64
  4. MIF4G domain containing protein regulates cell cycle and hepatic carcinogenesis by antagonizing CDK2-dependent p27 stability. (PMID: 24336329) Wan C. … Shen A. (Oncogene 2015) 3 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for MIF4GD Gene

Sources for MIF4GD Gene

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