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Aliases for MIF4GD Gene

Aliases for MIF4GD Gene

  • MIF4G Domain Containing 2 3 5
  • SLBP-Interacting Protein 1 2 3 4
  • SLIP1 3 4
  • SLBP (Stem Loop Binding Protein)-Interacting Protein 1 3
  • HSLIP1 4
  • AD023 3
  • MIFD 3

External Ids for MIF4GD Gene

Previous HGNC Symbols for MIF4GD Gene

  • MIFD

Previous GeneCards Identifiers for MIF4GD Gene

  • GC17M070774
  • GC17M073262
  • GC17M068672

Summaries for MIF4GD Gene

Entrez Gene Summary for MIF4GD Gene

  • This gene encodes a protein which interacts with the N-terminus of the stem-loop binding protein (SLBP) and the 3' end of histone mRNA. This interaction facilitates the activation of histone mRNA translation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011]

GeneCards Summary for MIF4GD Gene

MIF4GD (MIF4G Domain Containing) is a Protein Coding gene. GO annotations related to this gene include RNA binding and protein C-terminus binding. An important paralog of this gene is CTIF.

UniProtKB/Swiss-Prot for MIF4GD Gene

  • Functions in replication-dependent translation of histone mRNAs which differ from other eukaryotic mRNAs in that they do not end with a poly-A tail but a stem-loop. May participate in circularizing those mRNAs specifically enhancing their translation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIF4GD Gene

Genomics for MIF4GD Gene

Regulatory Elements for MIF4GD Gene

Enhancers for MIF4GD Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MIF4GD on UCSC Golden Path with GeneCards custom track

Promoters for MIF4GD Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MIF4GD on UCSC Golden Path with GeneCards custom track

Genomic Location for MIF4GD Gene

75,266,228 bp from pter
75,271,292 bp from pter
5,065 bases
Minus strand

Genomic View for MIF4GD Gene

Genes around MIF4GD on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIF4GD Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIF4GD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIF4GD Gene

Proteins for MIF4GD Gene

  • Protein details for MIF4GD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    MIF4G domain-containing protein
    Protein Accession:
    Secondary Accessions:
    • B4DUM7
    • Q8N4Q5
    • Q9HBL5

    Protein attributes for MIF4GD Gene

    222 amino acids
    Molecular mass:
    25423 Da
    Quaternary structure:
    • Interacts with EIF4G1, EIF4G2 and SLBP; probably tethered by SLBP to the 3-end of mRNAs ending with the histone stem-loop, it also interacts with EIF4G1 which is bound to their 5-end.
    • Depletion of MIF4GD results in cell death and reduced histone mRNA translation.
    • Sequence=AAG09724.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};

    Alternative splice isoforms for MIF4GD Gene


neXtProt entry for MIF4GD Gene

Proteomics data for MIF4GD Gene at MOPED

Post-translational modifications for MIF4GD Gene

  • Ubiquitination at Lys 53 and Lys 68
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for MIF4GD Gene

Domains & Families for MIF4GD Gene

Protein Domains for MIF4GD Gene

Suggested Antigen Peptide Sequences for MIF4GD Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 MIF4G domain.
  • Belongs to the MIF4GD family.
  • Contains 1 MIF4G domain.
  • Belongs to the MIF4GD family.
genes like me logo Genes that share domains with MIF4GD: view

No data available for Gene Families for MIF4GD Gene

Function for MIF4GD Gene

Molecular function for MIF4GD Gene

UniProtKB/Swiss-Prot Function:
Functions in replication-dependent translation of histone mRNAs which differ from other eukaryotic mRNAs in that they do not end with a poly-A tail but a stem-loop. May participate in circularizing those mRNAs specifically enhancing their translation.

Gene Ontology (GO) - Molecular Function for MIF4GD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
GO:0005515 protein binding IEA,IPI 16189514
genes like me logo Genes that share ontologies with MIF4GD: view
genes like me logo Genes that share phenotypes with MIF4GD: view

Animal Model Products

miRNA for MIF4GD Gene

miRTarBase miRNAs that target MIF4GD

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MIF4GD Gene

Localization for MIF4GD Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIF4GD Gene

Cytoplasm. Nucleus.

Subcellular locations from

Jensen Localization Image for MIF4GD Gene COMPARTMENTS Subcellular localization image for MIF4GD gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 2
peroxisome 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for MIF4GD Gene

Pathways & Interactions for MIF4GD Gene

SuperPathways for MIF4GD Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIF4GD Gene


No data available for Pathways by source and SIGNOR curated interactions for MIF4GD Gene

Drugs & Compounds for MIF4GD Gene

No Compound Related Data Available

Transcripts for MIF4GD Gene

Unigene Clusters for MIF4GD Gene

MIF4G domain containing:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MIF4GD Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c · 3d · 3e ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c · 8d · 8e
SP1: - - - -
SP2: - - -
SP3: - - - - - -
SP4: - - -
SP5: - - - - - - - -
SP6: - - - -
SP7: - - -
SP8: - - - -
SP9: - - - -
SP11: - -

Relevant External Links for MIF4GD Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIF4GD Gene

mRNA expression in normal human tissues for MIF4GD Gene

Protein differential expression in normal tissues from HIPED for MIF4GD Gene

This gene is overexpressed in Peripheral blood mononuclear cells (21.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MIF4GD Gene

SOURCE GeneReport for Unigene cluster for MIF4GD Gene Hs.325631

genes like me logo Genes that share expression patterns with MIF4GD: view

Protein tissue co-expression partners for MIF4GD Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MIF4GD Gene

Orthologs for MIF4GD Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIF4GD Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MIF4GD 35
  • 94.44 (n)
  • 97.75 (a)
  • 97 (a)
(Canis familiaris)
Mammalia MIF4GD 35
  • 92.94 (n)
  • 98.2 (a)
-- 36
  • 61 (a)
-- 36
  • 98 (a)
(Mus musculus)
Mammalia Mif4gd 35
  • 91.29 (n)
  • 93.24 (a)
Mif4gd 16
Mif4gd 36
  • 93 (a)
(Pan troglodytes)
Mammalia MIF4GD 35
  • 99.87 (n)
  • 100 (a)
  • 89 (a)
(Rattus norvegicus)
Mammalia Mif4gd 35
  • 91.29 (n)
  • 94.14 (a)
(Monodelphis domestica)
Mammalia MIF4GD 36
  • 91 (a)
(Ornithorhynchus anatinus)
Mammalia MIF4GD 36
  • 77 (a)
(Gallus gallus)
Aves MIF4GD 35
  • 78.68 (n)
  • 83.78 (a)
  • 83 (a)
(Anolis carolinensis)
Reptilia MIF4GD 36
  • 68 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mif4gd 35
  • 72.96 (n)
  • 76.5 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC53513 35
(Danio rerio)
Actinopterygii mif4gdb 35
  • 72.07 (n)
  • 73.87 (a)
zgc64152 35
mif4gda 36
  • 66 (a)
mif4gdb 36
  • 73 (a)
Species with no ortholog for MIF4GD:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIF4GD Gene

Gene Tree for MIF4GD (if available)
Gene Tree for MIF4GD (if available)

Paralogs for MIF4GD Gene

Paralogs for MIF4GD Gene

genes like me logo Genes that share paralogs with MIF4GD: view

Variants for MIF4GD Gene

Sequence variations from dbSNP and Humsavar for MIF4GD Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs4789162 -- 75,267,201(+) CTTCA(A/T)CCCAC intron-variant
rs4789163 -- 75,267,202(+) TTCAT(A/C)CCACT intron-variant
rs11267775 -- 75,267,185(+) GTCTC(-/CAAACCACTTCTT)CAAAC intron-variant
rs12103470 -- 75,268,717(+) AGAGg(A/G)cctgg intron-variant
rs59896034 -- 75,269,014(+) AAAAA(-/A)GGGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MIF4GD Gene

Variant ID Type Subtype PubMed ID
nsv908758 CNV Loss 21882294
nsv908760 CNV Loss 21882294
nsv510727 CNV Loss 20534489
nsv908761 CNV Loss 21882294

Variation tolerance for MIF4GD Gene

Residual Variation Intolerance Score: 18.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.16; 75.80% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for MIF4GD Gene

Disorders for MIF4GD Gene

Relevant External Links for MIF4GD

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MIF4GD Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIF4GD Gene

Publications for MIF4GD Gene

  1. SLIP1, a factor required for activation of histone mRNA translation by the stem-loop binding protein. (PMID: 18025107) Cakmakci N.G. … Marzluff W.F. (Mol. Cell. Biol. 2008) 2 3 4 67
  2. INT6 interacts with MIF4GD/SLIP1 and is necessary for efficient histone mRNA translation. (PMID: 22532700) Neusiedler J. … Jalinot P. (RNA 2012) 2 3
  3. Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. (PMID: 26871637) Yang X. … Vidal M. (Cell 2016) 3
  4. MIF4G domain containing protein regulates cell cycle and hepatic carcinogenesis by antagonizing CDK2-dependent p27 stability. (PMID: 24336329) Wan C. … Shen A. (Oncogene 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for MIF4GD Gene

Sources for MIF4GD Gene