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Aliases for MIF4GD Gene

Aliases for MIF4GD Gene

  • MIF4G Domain Containing 2 3
  • SLBP-Interacting Protein 1 3 4
  • SLIP1 3 4
  • SLBP (Stem Loop Binding Protein)-Interacting Protein 1 3
  • HSLIP1 4
  • AD023 3
  • MIFD 3

External Ids for MIF4GD Gene

Previous HGNC Symbols for MIF4GD Gene

  • MIFD

Previous GeneCards Identifiers for MIF4GD Gene

  • GC17M070774
  • GC17M073262
  • GC17M068672

Summaries for MIF4GD Gene

Entrez Gene Summary for MIF4GD Gene

  • This gene encodes a protein which interacts with the N-terminus of the stem-loop binding protein (SLBP) and the 3' end of histone mRNA. This interaction facilitates the activation of histone mRNA translation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011]

GeneCards Summary for MIF4GD Gene

MIF4GD (MIF4G Domain Containing) is a Protein Coding gene. GO annotations related to this gene include RNA binding and protein C-terminus binding. An important paralog of this gene is CTIF.

UniProtKB/Swiss-Prot for MIF4GD Gene

  • Functions in replication-dependent translation of histone mRNAs which differ from other eukaryotic mRNAs in that they do not end with a poly-A tail but a stem-loop. May participate in circularizing those mRNAs specifically enhancing their translation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIF4GD Gene

Genomics for MIF4GD Gene

Regulatory Elements for MIF4GD Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MIF4GD Gene

Chromosome:
17
Start:
75,266,228 bp from pter
End:
75,271,292 bp from pter
Size:
5,065 bases
Orientation:
Minus strand

Genomic View for MIF4GD Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIF4GD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIF4GD Gene

Proteins for MIF4GD Gene

  • Protein details for MIF4GD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A9UHW6-MI4GD_HUMAN
    Recommended name:
    MIF4G domain-containing protein
    Protein Accession:
    A9UHW6
    Secondary Accessions:
    • B4DUM7
    • Q8N4Q5
    • Q9HBL5

    Protein attributes for MIF4GD Gene

    Size:
    222 amino acids
    Molecular mass:
    25423 Da
    Quaternary structure:
    • Interacts with EIF4G1, EIF4G2 and SLBP; probably tethered by SLBP to the 3-end of mRNAs ending with the histone stem-loop, it also interacts with EIF4G1 which is bound to their 5-end.
    Miscellaneous:
    • Depletion of MIF4GD results in cell death and reduced histone mRNA translation
    SequenceCaution:
    • Sequence=AAG09724.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};

    Alternative splice isoforms for MIF4GD Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MIF4GD Gene

Proteomics data for MIF4GD Gene at MOPED

Post-translational modifications for MIF4GD Gene

  • Ubiquitination at Lys 53 and Lys 68
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for MIF4GD Gene

Domains & Families for MIF4GD Gene

Protein Domains for MIF4GD Gene

Suggested Antigen Peptide Sequences for MIF4GD Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A9UHW6

UniProtKB/Swiss-Prot:

MI4GD_HUMAN :
  • Contains 1 MIF4G domain.
  • Belongs to the MIF4GD family.
Domain:
  • Contains 1 MIF4G domain.
Family:
  • Belongs to the MIF4GD family.
genes like me logo Genes that share domains with MIF4GD: view

No data available for Gene Families for MIF4GD Gene

Function for MIF4GD Gene

Molecular function for MIF4GD Gene

UniProtKB/Swiss-Prot Function:
Functions in replication-dependent translation of histone mRNAs which differ from other eukaryotic mRNAs in that they do not end with a poly-A tail but a stem-loop. May participate in circularizing those mRNAs specifically enhancing their translation.

Gene Ontology (GO) - Molecular Function for MIF4GD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
GO:0005488 binding --
GO:0005515 protein binding IPI 16189514
GO:0008022 protein C-terminus binding IPI 17577209
genes like me logo Genes that share ontologies with MIF4GD: view
genes like me logo Genes that share phenotypes with MIF4GD: view

Animal Model Products

miRNA for MIF4GD Gene

miRTarBase miRNAs that target MIF4GD

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MIF4GD

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for MIF4GD Gene

Localization for MIF4GD Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIF4GD Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MIF4GD Gene COMPARTMENTS Subcellular localization image for MIF4GD gene
Compartment Confidence
nucleus 4
cytosol 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for MIF4GD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with MIF4GD: view

Pathways & Interactions for MIF4GD Gene

SuperPathways for MIF4GD Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIF4GD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006417 regulation of translation IEA --
genes like me logo Genes that share ontologies with MIF4GD: view

No data available for Pathways by source and SIGNOR curated interactions for MIF4GD Gene

Drugs & Compounds for MIF4GD Gene

No Compound Related Data Available

Transcripts for MIF4GD Gene

Unigene Clusters for MIF4GD Gene

MIF4G domain containing:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MIF4GD

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIF4GD Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c · 3d · 3e ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c · 8d · 8e
SP1: - - - -
SP2: - - -
SP3: - - - - - -
SP4: - - -
SP5: - - - - - - - -
SP6: - - - -
SP7: - - -
SP8: - - - -
SP9: - - - -
SP10:
SP11: - -

Relevant External Links for MIF4GD Gene

GeneLoc Exon Structure for
MIF4GD
ECgene alternative splicing isoforms for
MIF4GD

Expression for MIF4GD Gene

mRNA expression in normal human tissues for MIF4GD Gene

Protein differential expression in normal tissues from HIPED for MIF4GD Gene

This gene is overexpressed in Peripheral blood mononuclear cells (21.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MIF4GD Gene



SOURCE GeneReport for Unigene cluster for MIF4GD Gene Hs.325631

genes like me logo Genes that share expression patterns with MIF4GD: view

Protein tissue co-expression partners for MIF4GD Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MIF4GD Gene

Orthologs for MIF4GD Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIF4GD Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MIF4GD 35
  • 94.44 (n)
  • 97.75 (a)
MIF4GD 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MIF4GD 35
  • 92.94 (n)
  • 98.2 (a)
-- 36
  • 61 (a)
OneToMany
-- 36
  • 98 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Mif4gd 35
  • 91.29 (n)
  • 93.24 (a)
Mif4gd 16
Mif4gd 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MIF4GD 35
  • 99.87 (n)
  • 100 (a)
MIF4GD 36
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mif4gd 35
  • 91.29 (n)
  • 94.14 (a)
oppossum
(Monodelphis domestica)
Mammalia MIF4GD 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MIF4GD 36
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves MIF4GD 35
  • 78.68 (n)
  • 83.78 (a)
MIF4GD 36
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MIF4GD 36
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mif4gd 35
  • 72.96 (n)
  • 76.5 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC53513 35
zebrafish
(Danio rerio)
Actinopterygii mif4gdb 35
  • 72.07 (n)
  • 73.87 (a)
zgc64152 35
mif4gda 36
  • 66 (a)
OneToMany
mif4gdb 36
  • 73 (a)
OneToMany
Species with no ortholog for MIF4GD:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIF4GD Gene

ENSEMBL:
Gene Tree for MIF4GD (if available)
TreeFam:
Gene Tree for MIF4GD (if available)

Paralogs for MIF4GD Gene

Paralogs for MIF4GD Gene

genes like me logo Genes that share paralogs with MIF4GD: view

Variants for MIF4GD Gene

Sequence variations from dbSNP and Humsavar for MIF4GD Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs4789162 -- 75,267,201(+) CTTCA(A/T)CCCAC intron-variant
rs4789163 -- 75,267,202(+) TTCAT(A/C)CCACT intron-variant
rs11267775 -- 75,267,185(+) GTCTC(-/CAAACCACTTCTT)CAAAC intron-variant
rs12103470 -- 75,268,717(+) AGAGg(A/G)cctgg intron-variant
rs55815500 -- 75,267,200(+) CTTCA(-/AACCACTTCTTCA)TCCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MIF4GD Gene

Variant ID Type Subtype PubMed ID
nsv908758 CNV Loss 21882294
nsv908760 CNV Loss 21882294
nsv510727 CNV Loss 20534489
nsv908761 CNV Loss 21882294

Variation tolerance for MIF4GD Gene

Residual Variation Intolerance Score: 18.19% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.16; 75.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MIF4GD Gene

HapMap Linkage Disequilibrium report
MIF4GD

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MIF4GD Gene

Disorders for MIF4GD Gene

Relevant External Links for MIF4GD

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIF4GD
genes like me logo Genes that share disorders with MIF4GD: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIF4GD Gene

Publications for MIF4GD Gene

  1. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  2. MIF4G domain containing protein regulates cell cycle and hepatic carcinogenesis by antagonizing CDK2-dependent p27 stability. (PMID: 24336329) Wan C. … Shen A. (Oncogene 2015) 67
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67
  4. Structural and biochemical studies of SLIP1-SLBP identify DBP5 and eIF3g as SLIP1-binding proteins. (PMID: 23804756) von Moeller H. … Conti E. (Nucleic Acids Res. 2013) 67
  5. Assembly of the SLIP1-SLBP complex on histone mRNA requires heterodimerization and sequential binding of SLBP followed by SLIP1. (PMID: 23286197) Bansal N. … Thapar R. (Biochemistry 2013) 67

Products for MIF4GD Gene

Sources for MIF4GD Gene

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