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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MIF Gene

protein-coding   GIFtS: 70
GCID: GC22P024236

Macrophage Migration Inhibitory Factor (Glycosylation-Inhibiting...


(Previous symbol: GLIF)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Macrophage Migration Inhibitory Factor (Glycosylation-Inhibiting
Factor)1 2
     L-Dopachrome Tautomerase2 3
GLIF1 2 3     Macrophage Migration Inhibitory Factor2
Phenylpyruvate Tautomerase2 3     EC 5.3.2.13
GIF2 3     EC 5.3.3.123
MMIF2 3     Glycosylation-Inhibiting Factor3
L-Dopachrome Isomerase2 3     

External Ids:    HGNC: 70971   Entrez Gene: 42822   Ensembl: ENSG000002409727   OMIM: 1536205   UniProtKB: P141743   

Export aliases for MIF gene to outside databases

Previous GC identifers: GC22P020896 GC22P022560 GC22P022561 GC22P022369 GC22P007221


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MIF Gene:
This gene encodes a lymphokine involved in cell-mediated immunity, immunoregulation, and inflammation. It plays a
role in the regulation of macrophage function in host defense through the suppression of anti-inflammatory
effects of glucocorticoids. This lymphokine and the JAB1 protein form a complex in the cytosol near the
peripheral plasma membrane, which may indicate an additional role in integrin signaling pathways. (provided by
RefSeq, Jul 2008)

GeneCards Summary for MIF Gene: 
MIF (macrophage migration inhibitory factor (glycosylation-inhibiting factor)) is a protein-coding gene. Diseases associated with MIF include juvenile rheumatoid arthritis, and ornithosis, and among its related super-pathways are MIF Mediated Glucocorticoid Regulation and Tyrosine metabolism. GO annotations related to this gene include chemoattractant activity and receptor binding.

UniProtKB/Swiss-Prot: MIF_HUMAN, P14174
Function: Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression
of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host
defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and
dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether
the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity

Gene Wiki entry for MIF (Macrophage migration inhibitory factor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NC_018933.2  NT_011520.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MIF gene promoter:
         CREB   Sp1   p53   deltaCREB   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMIF promoter sequence
   Search SABiosciences Chromatin IP Primers for MIF

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MIF


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q11.23   Ensembl cytogenetic band:  22q11.23   HGNC cytogenetic band: 22q11.23

MIF Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MIF gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P024236:  view genomic region     (about GC identifiers)

Start:
24,236,191 bp from pter      End:
24,237,414 bp from pter
Size:
1,224 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MIF_HUMAN, P14174 (See protein sequence)
Recommended Name: Macrophage migration inhibitory factor  
Size: 115 amino acids; 12476 Da
Subunit: Homotrimer. Interacts with CXCR2 extracellular domain (By similarity). Interacts with the CD74
extracellular domain, COPS5 and BNIPL
Subcellular location: Secreted. Cytoplasm. Note=Does not have a cleavable signal sequence and is secreted via a
specialized, non-classical pathway. Secreted by macrophages upon stimulation by bacterial lipopolysaccharide
(LPS), or by M.tuberculosis antigens
Miscellaneous: Serum levels of MIF are elevated in patients with severe sepsis or septic shock. High levels of MIF
are correlated with low survival. Drugs that inhibit tautomerase activity protect against death due to sepsis
6/34 PDB 3D structures from and Proteopedia for MIF (see all 34):
1CA7 (3D)        1CGQ (3D)        1GCZ (3D)        1GD0 (3D)        1GIF (3D)        1LJT (3D)    
Secondary accessions: A5Z1R8 B2R4S3 Q2V4Y5 Q6FHV0

Explore the universe of human proteins at neXtProt for MIF: NX_P14174

Explore proteomics data for MIF at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P14174

  • MIF Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MIF Protein Expression
    REFSEQ proteins: NP_002406.1  
    ENSEMBL proteins: 
     ENSP00000215754  

    Human Recombinant Protein Products for MIF: 
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    Browse recombinant and purified proteins available from Enzo Life Sciences
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    OriGene Protein Over-expression Lysate for MIF
    OriGene MassSpec for MIF 
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    GenScript Purified and Recombinant Proteins for MIF
    Novus Biologicals MIF Proteins
    Novus Biologicals MIF Lysates
    Sino Biological Recombinant Protein for MIF
    Sino Biological Cell Lysate for MIF 
    ProSpec Recombinant Protein for MIF
    Cloud-Clone Corp. Proteins for MIF 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IDA12782713
    GO:0005615extracellular space IEA--
    GO:0005737cytoplasm IEA--
    GO:0009986cell surface IDA12782713

    MIF for ontologies           About GeneDecksing



    MIF Antibody Products: 
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    Abcam antibodies for MIF
    Cloud-Clone Corp. Antibodies for MIF 
    ThermoFisher Antibody for MIF
    LSBio Antibodies in human, mouse, rat for MIF 

    Assay Products for MIF: 
    Browse Kits and Assays available from EMD Millipore
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    R&D Systems ELISAs for MIF         (see all)
    GenScript Custom Assay Services for MIF
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MIF 
    Cloud-Clone Corp. CLIAs for MIF


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR014347 Tautomerase/MIF_sf
     IPR001398 Macrophage_inhib_fac
     IPR019829 Macrophage_inhib_fac_CS

    Graphical View of Domain Structure for InterPro Entry P14174

    ProtoNet protein and cluster: P14174

    1 Blocks protein domain: IPB001398 Macrophage migration inhibitory factor

    UniProtKB/Swiss-Prot: MIF_HUMAN, P14174
    Similarity: Belongs to the MIF family


    MIF for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MIF_HUMAN, P14174
    Function: Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression
    of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host
    defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and
    dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether
    the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity
    Catalytic activity: Keto-phenylpyruvate = enol-phenylpyruvate
    Catalytic activity: L-dopachrome = 5,6-dihydroxyindole-2-carboxylate
    Biophysicochemical properties: Kinetic parameters: KM=249 uM for phenylpyruvate; KM=168 uM for
    p-hydroxyphenylpyruvate; Vmax=2113 umol/min/mg enzyme toward phenylpyruvate; Vmax=524 umol/min/mg enzyme toward
    p-hydroxyphenylpyruvate;
    Induction: Up-regulated in concanavalin-A-treated lymphocytes. Up-regulated in macrophages upon exposure to
    M.tuberculosis antigens

         Genatlas biochemistry entry for MIF:
    macrophage migration inhibitory factor,12.3kDa,expressed in T cells and various tissues,including immunologically
    privileged lens and brain,also involved in mitogenic response and the control of cell cycle progression,maybe the
    same as DDT

         Enzyme Numbers (IUBMB): EC 5.3.3.121 EC 5.3.2.11

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004167dopachrome isomerase activity IDA17526494
    GO:0005102receptor binding IPI12782713
    GO:0005125cytokine activity IDA12782713
    GO:0005126cytokine receptor binding IPI17045821
    GO:0005515protein binding IPI12681488
         
    MIF for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for MIF:
     Proliferating cells 

         6 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Mif):
     cellular  hematopoietic system  homeostasis/metabolism  immune system  normal 
     tumorigenesis 

    MIF for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for MIF: Miftm1Mky Miftm1Gfr Miftm1Dvd

       inGenious Targeting Laboratory - Custom generated mouse model solutions for MIF 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MIF

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MIF 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MIF 

    miRNA
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    miRTarBase miRNAs that target MIF:
    hsa-mir-451 (MIRT000046)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MIF
    1 QIAGEN miScript miRNA Assays for microRNA that regulate MIF:
    hsa-miR-629*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MIF
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of MIF

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for MIF (see all 7)
    OriGene ORF clones in mouse, rat for MIF
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MIF (NM_002415)
    Sino Biological Human cDNA Clone for MIF
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MIF
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MIF
    Sirion Biotech Customized lentivirus for stable overexpression of MIF 
                         Customized lentivirus expression plasmids for stable overexpression of MIF 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for MIF
    Search LifeMap BioReagents cell lines for MIF
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MIF


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MIF About   (see all 8)                                                                                              See pathways by source

    SuperPathContained pathways About
    1PEDF Induced Signaling
    MIF Mediated Glucocorticoid Regulation0.94
    MIF Regulation of Innate Immune Cells0.94
    2Phenylalanine metabolism
    Phenylalanine metabolism0.36
    Tyrosine metabolism0.36
    3Immune response MIF-mediated glucocorticoid regulation
    Immune response MIF-mediated glucocorticoid regulation1.00
    4Toll Comparative Pathway
    Immune response MIF in innate immunity response0.46
    5Cell cycle Cell cycle (generic schema)
    Immune response MIF-JAB1 signaling0.32

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 EMD Millipore Pathways for MIF
        Immune response MIF-mediated glucocorticoid regulation
    Immune response MIF in innate immunity response
    Immune response MIF-JAB1 signaling

    3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MIF
        MIF Regulation of Innate Immune Cells
    MIF Mediated Glucocorticoid Regulation
    MIF Action Through Endocytic Pathway

    3 GeneGo (Thomson Reuters) Pathways for MIF
        Immune response MIF-mediated glucocorticoid regulation
    Immune response MIF in innate immunity response
    Immune response MIF-JAB1 signaling

    2 BioSystems Pathways for MIF
        Adipogenesis
    Spinal Cord Injury



    2         Kegg Pathways  (Kegg details for MIF):
        Tyrosine metabolism
    Phenylalanine metabolism


    MIF for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MIF

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/106 Interacting proteins for MIF (P141741, 2, 3 ENSP000002157544) via UniProtKB, MINT, STRING, and/or I2D (see all 106)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    COPS5Q929052, 3, ENSP000003505124MINT-58209 MINT-58211 MINT-58210 I2D: score=5 STRING: ENSP00000350512
    STRN4Q9NRL32, 3MINT-65601 I2D: score=4 
    COPS6Q7L5N12, 3, ENSP000003041024MINT-58212 I2D: score=3 STRING: ENSP00000304102
    CD74P042333, ENSP000000095304I2D: score=4 STRING: ENSP00000009530
    BNIPLQ7Z4653, ENSP000003579274I2D: score=3 STRING: ENSP00000357927
    About this table

    Gene Ontology (GO): 5/36 biological process terms (GO ID links to tree view) (see all 36):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001516prostaglandin biosynthetic process IDA12782713
    GO:0001934positive regulation of protein phosphorylation ----
    GO:0002906negative regulation of mature B cell apoptotic process IEA--
    GO:0006954inflammatory response IEA--
    GO:0007166cell surface receptor signaling pathway IDA12782713

    MIF for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MIF for compounds           About GeneDecksing

    EMD Millipore small molecules for MIF:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for MIF available from Tocris Bioscience    About this table
    CompoundAction CAS #
    AS 101 Immunomodulator; inhibits IL-10 synthesis and potentiates IL-1alpha, IL-2 and TNF-alpha release [106566-58-9]
    PirfenidoneAntifibrotic agent; regulates cytokine levels in vivo[53179-13-8]
    GIT 27Immunomodulator; reduces production of pro-inflammatory cytokines[6501-72-0]
    4-IPPInhibitor of macrophage migration inhibitory factor (MIF); suicide substrate[41270-96-6]
    ThalidomideTNF-alpha synthesis inhibitor[50-35-1]

    4 HMDB Compounds for MIF    About this table
    CompoundSynonyms CAS #PubMed Ids
    Enol-phenylpyruvate2-Hydroxy-3-phenylpropenoate (see all 5)5801-57-013416270
    2-Hydroxy-3-(4-hydroxyphenyl)propenoic acid2-Hydroxy-3-(4-hydroxyphenyl)propenoate (see all 3)----
    4-Hydroxyphenylpyruvic acid(p-Hydroxyphenyl)pyruvate (see all 25)156-39-8--
    Phenylpyruvic acid2-Oxo-3-phenylpropanoate (see all 16)156-06-9--

    9 DrugBank Compounds for MIF    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    7-Hydroxy-2-Oxo-Chromene-3-Carboxylic Acid Ethyl Ester-- --target--17139284 17016423 10592235
    Citric Acid-- 77-92-9target--17139284 17016423
    3,4-Dihydroxycinnamic Acid-- 331-39-5target--10592235
    3-(4-HYDROXY-PHENYL)PYRUVIC ACID-- --target--10592235
    3-(4-HYDROXYPHENYL)-4,5-DIHYDRO-5-ISOXAZOLE-ACETIC ACID METHYL ESTER-- --target--10592235
    3-FLUORO-4-HYDROXYBENZALDEHYDE O-(CYCLOHEXYLCARBONYL)OXIME-- --target--10592235
    4-HYDROXYBENZALDEHYDE O-(3,3-DIMETHYLBUTANOYL)OXIME-- --target--10592235
    4-HYDROXYBENZALDEHYDE O-(CYCLOHEXYLCARBONYL)OXIME-- --target--10592235
    6-HYDROXY-1,3-BENZOTHIAZOLE-2-SULFONAMIDE-- --target--10592235

    10/76 Novoseek inferred chemical compound relationships for MIF gene (see all 76)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    d-dopachrome 94 30 10079069 (3), 8900542 (2), 9443822 (2), 9716662 (2) (see all 17)
    5-carboxymethyl-2-hydroxymuconate 90.2 9 10079069 (1), 10353846 (1), 10504254 (1), 9443822 (1) (see all 6)
    l-dopachrome 85.2 6 8900542 (1), 9794786 (1), 11032394 (1), 10504254 (1) (see all 5)
    (e)-2-fluoro-p-hydroxycinnamate 84.4 2 10933783 (1), 16279779 (1)
    chmi 84.3 6 18695941 (2), 9665726 (1), 10079069 (1)
    4-oxalocrotonate 73.6 8 10079069 (1), 10353846 (1), 10504254 (1), 12382291 (1) (see all 5)
    5,6-dihydroxyindole 71.5 2 11032394 (1), 9464626 (1)
    4-hydroxyphenylpyruvate 68.6 11 10353846 (2), 11439086 (2), 9395080 (1), 10504254 (1) (see all 6)
    dopaminochrome 59.3 2 10644007 (1), 12835099 (1)
    dopachrome 56.2 8 9794786 (3), 9614090 (1), 10576686 (1), 15145447 (1)

    Search CenterWatch for drugs/clinical trials and news about MIF

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MIF gene: 
    NM_002415.1  

    Unigene Cluster for MIF:

    Macrophage migration inhibitory factor (glycosylation-inhibiting factor)
    Hs.407995  [show with all ESTs]
    Unigene Representative Sequence: BQ056329
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000215754(uc002zyr.1) ENST00000465752(uc011aje.2) ENST00000498385

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MIF
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    Clone
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    OriGene clones in human, mouse for MIF (see all 7)
    OriGene ORF clones in mouse, rat for MIF
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    GenScript: all cDNA clones in your preferred vector: MIF (NM_002415)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MIF
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MIF
    Sirion Biotech Customized lentivirus for stable overexpression of MIF 
                         Customized lentivirus expression plasmids for stable overexpression of MIF 
    Primer
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    OriGene qPCR primer pairs and template standards for MIF
    OriGene qSTAR qPCR primer pairs in human, mouse for MIF
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MIF
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MIF

    Additional mRNA sequence: 

    AF469046.1 AK311929.1 BC000447.2 BC007376.2 BC007676.1 BC008914.2 BC013976.2 BC022414.1 
    BC051440.1 BC053376.1 BT007148.1 CR407644.1 CR456520.1 CR541651.1 EF611126.1 JQ846015.1 
    L10612.1 M25639.1 M95775.1 Z23063.1 

    22 DOTS entries:

    DT.99959987  DT.100045729  DT.451973  DT.92458820  DT.97857690  DT.91661314  DT.100853589  DT.100691841 
    DT.100691845  DT.92458819  DT.100691852  DT.120669373  DT.120669415  DT.95202663  DT.120669428  DT.100763736 
    DT.120669362  DT.100691842  DT.91653854  DT.91845241  DT.91878116  DT.95234056 

    24/1476 AceView cDNA sequences (see all 1476):

    BQ652740 CB851923 AW160393 BM696446 CA432812 BM808120 AI417316 AW193906 
    AW009548 BM504318 AJ271290 CR602271 H44219 BU077824 BU857402 AI084213 
    BG168686 BM687377 AW468709 CB160664 BQ681639 CD674111 CD676270 BC063525 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MIF expression in normal human tissues (normalized intensities)      MIF embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AACGCGGCCA
    MIF Expression
    About this image


    MIF expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/24 selected tissues (see all 24) fully expand
     
     Brain (Nervous System)    fully expand to see all 10 entries
             Thalamus
             ganglion/cranial   
     
     Lower Urinary Tract (Urinary System)    fully expand to see all 3 entries
             Ureter
             visceral organ   
     
     Heart (Cardiovascular System)    fully expand to see all 3 entries
             heart/ventricle   
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Mesenchymal Stem Cells
             Decidua-derived mesenchymal stem cells

    See MIF Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MIF

    SOURCE GeneReport for Unigene cluster: Hs.407995
        SABiosciences Expression via Pathway-Focused PCR Arrays including MIF (see all 10): 
              Amino Acid Metabolism II in human mouse rat
              Wound Healing in human mouse rat
              DNA Damage Signaling Pathway in human mouse rat
              Hypoxia Signaling Pathway in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for MIF gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mif1 , 5 macrophage migration inhibitory factor1, 5 88.7(n)1
    89.57(a)1
      10 (38.59 cM)5
    173191  NM_010798.21  NP_034928.11 
     758593535 
    chicken
    (Gallus gallus)
    Aves MIF1 macrophage migration inhibitory factor (glycosylation-inhibiting more 75.07(n)
    71.3(a)
      100857237  XM_003642234.1  XP_003642282.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia MIF2 macrophage migration inhibitory factor 73.19(n)    AB111063.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.78562 Danio rerio, clone IMAGE5776860, mRNA 78.1(n)    BC049029.1 
    worm
    (Caenorhabditis elegans)
    Secernentea mif-16
    Protein MIF-1
    35(a)
    1 ↔ 1
    III(11847902-11850034)


    ENSEMBL Gene Tree for MIF (if available)
    TreeFam Gene Tree for MIF (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MIF gene
    2 SIMAP similar genes for MIF using alignment to 2 protein entries:     MIF_HUMAN (see all proteins):
    DDT    DDTL

    MIF for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/155 SNPs in MIF are shown (see all 155)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs20121241,2
    C,F,A,H--8189433(+) GGTTCC/TGAATG 1 -- us2k132Minor allele frequency- T:0.23NS EA NA WA CSA 2942
    rs20121331,2
    C,F,A,H--8189503(+) GTCTCG/CGGGTT 1 -- us2k129Minor allele frequency- C:0.18NS EA NA WA CSA 2536
    rs124838591,2
    C,F,H--8189576(+) TTAGCT/CATTAG 1 -- us2k112Minor allele frequency- C:0.27NS NA WA CSA EA 552
    rs124850581,2
    C,F,H--8189628(+) GGGGAA/GCTTAG 1 -- us2k116Minor allele frequency- G:0.19NS EA NA CSA WA 950
    rs1453831651,2
    C--8189685(+) GCCAGA/GTAAGG 1 -- us2k10--------
    rs124850681,2
    C,F,H--8189703(+) TTGTTA/GTGGTA 1 -- us2k19Minor allele frequency- G:0.19NS NA WA EA 546
    rs124838841,2
    C,F,H--8189704(+) TGTTAT/CGGTAA 1 -- us2k114Minor allele frequency- C:0.18NS EA NA WA CSA 826
    rs114283101,2
    C,F--8189882(+) GAGTC-/AGGGGC 1 -- us2k16Minor allele frequency- A:0.20NS CSA 192
    rs339192361,2
    C--8189883(+) AGTCG-/AGGGCT 1 -- us2k10--------
    rs48224431,2
    C,F,A,H--8189967(+) GTCCAG/AGCCAA 1 -- us2k128Minor allele frequency- A:0.21NS EA NA CSA WA 3116

    HapMap Linkage Disequilibrium report for MIF (24236191 - 24237414 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for MIF:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2724041CNV Deletion23290073
    nsv3577CNV Insertion18451855
    nsv914604CNV Loss21882294
    nsv526567CNV Gain19592680
    dgv4906n71CNV Gain21882294
    nsv914599CNV Gain21882294
    nsv834155CNV Gain+Loss17160897
    nsv511075CNV Complex20534489
    nsv7350OTHER Inversion18451855


    Human Gene Mutation Database (HGMD): MIF
    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for MIF

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 153620   
    OMIM disorders: 604302  
    UniProtKB/Swiss-Prot: MIF_HUMAN, P14174
  • Rheumatoid arthritis systemic juvenile (RASJ) [MIM:604302]: An inflammatory articular disorder with
    systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with
    severe extraarticular features and occasionally fatal complications. During active phases of the disorder,
    patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly,
    serositis, myalgia and arthritis. Note=Disease susceptibility is associated with variations affecting the gene
    represented in this entry

  • 20/172 diseases for MIF (see all 172):    About MalaCards
    juvenile rheumatoid arthritis    ornithosis    systemic onset juvenile idiopathic arthritis    cysticercosis
    ocular cicatricial pemphigoid    chikungunya    arthus reaction    macular holes
    melioidosis    rheumatoid vasculitis    hemosiderosis    proliferative diabetic retinopathy
    cicatricial pemphigoid    keratitis    glucocorticoid resistance    malaria
    adult-onset still's disease    acute pyelonephritis    pyelonephritis    plasmodium falciparum malaria

    1 disease from the University of Copenhagen DISEASES database for MIF:
    Rheumatoid arthritis

    MIF for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/93 Novoseek inferred disease relationships for MIF gene (see all 93)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    shock septic 59.1 50 11397892 (4), 10655104 (3), 16125329 (3), 12792855 (2) (see all 28)
    inflammation 57.3 93 15659324 (4), 11673308 (3), 2260882 (2), 15225126 (2) (see all 64)
    sepsis 54.1 118 19756498 (7), 17443469 (6), 19509463 (6), 16115897 (4) (see all 39)
    rheumatoid arthritis 52.8 45 16628200 (3), 17166737 (2), 18442790 (2), 17869648 (2) (see all 33)
    necrosis 49.2 61 11377135 (2), 12480958 (1), 14621041 (1), 15037585 (1) (see all 55)
    systemic inflammatory response syndrome 47 6 16677407 (1), 19540674 (1), 20397261 (1), 17534704 (1) (see all 5)
    tumors 44.9 234 18171602 (7), 12925952 (6), 15973102 (5), 15064733 (5) (see all 99)
    arthritis 40.9 21 18078632 (2), 11207663 (2), 16465610 (2), 12746913 (1) (see all 12)
    autoimmune diseases 36.5 33 10719057 (3), 18721909 (2), 15577740 (2), 20148714 (2) (see all 19)
    hypersensitivity delayed 35.1 4 18288453 (1), 11032394 (1), 2307508 (1), 15770393 (1)

    Genetic Association Database (GAD): MIF
    Human Genome Epidemiology (HuGE) Navigator: MIF (107 documents)

    Export disorders for MIF gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MIF gene, integrated from 9 sources (see all 842):
    (articles sorted by number of sources associating them with MIF)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel 5'-flanking region polymorphism of macrophage migration inhibitory factor is associated with systemic-onset juvenile idiopathic arthritis. (PubMed id 11508429)1, 2, 4, 9 Donn R.P.... Thomson W. (2001)
    2. Molecular cloning of a cDNA encoding a human macrophage migration inhibitory factor. (PubMed id 2552447)1, 2, 3 Weiser W.Y.... David J.R. (1989)
    3. Molecular cloning and functional expression of a cDNA encoding glycosylation-inhibiting factor. (PubMed id 8234256)1, 2, 9 Mikayama T.... Ishii Y. (1993)
    4. Intracellular action of the cytokine MIF to modulate AP-1 activity and the cell cycle through Jab1. (PubMed id 11089976)1, 2, 9 Kleemann R.... Bernhagen J. (2000)
    5. Serum macrophage migration inhibitory factor (MIF) in the intercritical phase of hereditary periodic fevers and its relationship with the MIF-173G/C polymorphism. (PubMed id 17763209)1, 4, 9 Rigante D....Stabile A. (2007)
    6. Correlation of rheumatoid arthritis severity with the genetic functional variants and circulating levels of macrophage migration inhibitory factor. (PubMed id 16200611)1, 4, 9 Radstake T.R....van Riel P.L. (2005)
    7. Polymorphisms of the macrophage inhibitory factor and C-reactive protein genes in subjects with Alzheimer's dementia. (PubMed id 15286457)1, 4, 9 Flex A....Pola P. (2004)
    8. Association of proinflammatory cytokines with end sta ge renal disease. (PubMed id 20303284)1, 4, 9 Tripathi G....Agrawal S. (2010)
    9. Inflammatory cytokine gene polymorphisms increase the risk of atrophic gastritis and intestinal metaplasia. (PubMed id 20380014)1, 4, 9 Li Z.W....Li J.Y. (2010)
    10. A MIF haplotype is associated with the outcome of pat ients with severe sepsis: a case control study. (PubMed id 19941661)1, 4, 9 Lehmann L.E....StA1ber F. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4282 HGNC: 7097 AceView: MIFandSLC2A11 Ensembl:ENSG00000240972 euGenes: HUgn4282
    ECgene: MIF Kegg: 4282 H-InvDB: MIF

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MIF Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MIF Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/mif/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MIF gene:
    Search GeneIP for patents involving MIF

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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