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MIF Gene

protein-coding GIFtS: 71

GC22P022561

macrophage migration inhibitory factor (glycosylation-inhibiting factor)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: GLIF)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EC 5.3.2.1 ^³
GIF ^¹, ², ³
GLIF ^², ³
MMIF ^², ³

Descriptions
Glycosylation-inhibiting factor ^³
Phenylpyruvate tautomerase ^², ³
macrophage migration inhibitory factor ^²
macrophage migration inhibitory factor (glycosylation-inhibiting factor) ^²

External Ids
HGNC: 7097¹
Entrez Gene: 4282²
UniProtKB: P14174³
Ensembl: ENSG00000099964⁷

Search outside databases for aliases for MIF gene

Previous GC identifers: GC22P020896 GC22P022560 GC22P022369

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for MIF:

This gene encodes a lymphokine involved in cell-mediated immunity, immunoregulation, and

inflammation. It plays a role in the regulation of macrophage function in host defense through the

suppression of anti-inflammatory effects of glucocorticoids. This lymphokine and the JAB1 protein

form a complex in the cytosol near the peripheral plasma membrane, which may indicate an

additional role in integrin signaling pathways. [provided by RefSeq]

UniProtKB/Swiss-Prot: MIF_HUMAN, P14174

Function: The expression of MIF at sites of inflammation suggest a role for the mediator in

regulating the function of macrophage in host defense. Also acts as a phenylpyruvate tautomerase

Gene Wiki entry for MIF (Macrophage_migration_inhibitory_factor)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the MIF gene

Entrez Gene cytogenetic band: 22q11.23 Ensembl cytogenetic band: 22q11.23 HGNC cytogenetic band: 22q11.23

MIF Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 22 GeneLoc Exon Structure

GeneLoc location for GC22P022561: (about GC identifiers)

Start:	22,566,565 bp from pter
End:	22,567,409 bp from pter
Size:	845 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000022.9 NT_011520.11

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: MIF_HUMAN, P14174 (See protein sequence)

Recommended Name: Macrophage migration inhibitory factor

Size: 115 amino acids; 12476 Da

Subunit: Homotrimer. Interacts with COPS5 and BNIPL

PDB structures from and Proteopedia :

1CA7 (3D)

1CGQ (3D)

1GCZ (3D)

1GD0 (3D)

1GIF (3D)

1LJT (3D)

1MIF (3D)

1P1G (3D)

2OOH (3D)

2OOW (3D)

2OOZ (3D)

3B9S (3D)

3CE4 (3D)

3DJH (3D)

3DJI (3D)

Secondary accessions: Q2V4Y5

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_002406.1

ENSEMBL proteins:

ENSP00000215754

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	R&D Systems Recombinant & Natural Proteins for MIF
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (MIF)
	Human Recombinant Proteins from Abnova (MIF)

OriGene Purified Recombinant Human Protein: MIF

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IDA	12782713
GO:0005615	extracellular space	IEA	--

About this table

Antibodies for MIF:

	Invitrogen Antibodies for MIF
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for MIF
	R&D Systems Antibodies for MIF
	Antibodies from Abcam (MIF), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (MIF)
	Novus Biologicals Antibodies for MIF

Assays for MIF:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	R&D Systems ELISAs for MIF (see all)
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P14174

ProtoNet protein and cluster: P14174

1 Blocks protein family: IPB001398 Macrophage migration inhibitory factor

UniProtKB/Swiss-Prot: MIF_HUMAN, P14174

Similarity: Belongs to the MIF family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (MIF)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (MIF)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002415

Applied Biosystems Silencer® siRNAs for MIF

Sigma-Aldrich siRNA and siRNA Panels for MIF

Sigma-Aldrich shRNA Panels and shRNA for MIF

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for MIF
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_002415
Myc/DDK tagged cDNA clone in CMV expression vector: NM_002415
untagged cDNA clone in CMV expression vector: NM_002415

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_002415

UniProtKB/Swiss-Prot: MIF_HUMAN, P14174

Function: The expression of MIF at sites of inflammation suggest a role for the mediator in

regulating the function of macrophage in host defense. Also acts as a phenylpyruvate tautomerase

Catalytic activity: Keto-phenylpyruvate = enol-phenylpyruvate

Enzyme Number (IUBMB): EC 5.3.2.1

Genatlas biochemistry entry for MIF:

macrophage migration inhibitory factor,12.3kDa,expressed in T cells and various tissues,including

immunologically privileged lens and brain,also involved in mitogenic response and the control of

cell cycle progression,maybe the same as DDT

6 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Mif):

cellular	hematopoietic system	homeostasis/metabolism	immune system	normal
tumorigenesis

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005125	cytokine activity	IDA	12782713
GO:0005515	protein binding	IPI	12681488 12782713
GO:0016853	isomerase activity	IEA	--
GO:0050178	phenylpyruvate tautomerase activity	IDA	16285950

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

3 Sigma-Aldrich "Your Favorite Gene" Pathways for MIF (Your Favorite Gene powered by Ingenuity)

Tyrosine Metabolism
MIF Regulation of Innate Immunity
Phenylalanine Metabolism

GeneDecks MIF for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for MIF

5/31 Interacting proteins for MIF (ENSP00000215754³ P14174^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 31 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
COPS5	Q92905²	STRING (score=.989) MINT-58209 MINT-58211 MINT-58210
COPS6	Q7L5N1²	STRING (score=.771) MINT-58212
BCL2L11	O43521-1¹	STRING (score=.937) EBI-372712, EBI-526416
DSTYK	Q6XUX3¹	EBI-372712, EBI-1049520
FIBP	O43427¹	EBI-372712, EBI-724809

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5/6 Gene Ontology (GO) biological process terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001516	prostaglandin biosynthetic process	IDA	12782713
GO:0006954	inflammatory response	IEA	--
GO:0007166	cell surface receptor linked signal transduction	IDA	12782713
GO:0008283	cell proliferation	IDA	12782713
GO:0043030	regulation of macrophage activation	NAS	12782713

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Sigma-Aldrich Small Molecules for MIF:

Inhibitor

Browse Tocris compounds for MIF
10/44 Novoseek chemical compound relationships for MIF gene (see all 44 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
d-dopachrome	94.28	30	10079069 (3), 8900542 (2), 9443822 (2), 9716662 (2) (see all 17)
5-carboxymethyl-2-hydroxymuconate	90.77	9	10079069 (1), 10353846 (1), 10504254 (1), 9443822 (1) (see all 6)
l-dopachrome	85.88	6	8900542 (1), 9794786 (1), 11032394 (1), 10504254 (1) (see all 5)
(e)-2-fluoro-p-hydroxycinnamate	85.09	2	10933783 (1), 16279779 (1)
chmi	85.01	6	18695941 (2), 9665726 (1), 10079069 (1)
4-oxalocrotonate	74.71	8	10079069 (1), 10353846 (1), 10504254 (1), 12382291 (1) (see all 5)
dopaminochrome	60.91	2	10644007 (1), 12835099 (1)
dopachrome	58.07	8	9794786 (3), 9614090 (1), 10576686 (1), 15145447 (1)
phenyl agarose	56.01	3	9560321 (1), 9794786 (1)
hemozoin	50.76	9	17060471 (3), 16929348 (1), 10722628 (1), 16636133 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (MIF)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (MIF)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002415

Sigma-Aldrich siRNA and siRNA Panels for MIF

Sigma-Aldrich shRNA Panels and shRNA for MIF

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_002415

REFSEQ mRNAs for MIF gene:

NM_002415.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_002415

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_002415
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_002415
                                 untagged cDNA clone in CMV expression vector: NM_002415

Additional cDNA sequence:

AF469046.1 AK311929.1 BC000447.2 BC007376.2 BC007676.1 BC008914.2 BC013976.2 BC022414.1

BC051440.1 BC053376.1 BT007148.1 CR407644.1 CR456520.1 CR541651.1 CR602271.1 CR606770.1

EF611126.1 L10612.1 M25639.1 M95775.1 Z23063.1

22 DOTS entries:

DT.99959987 DT.100045729 DT.92458820 DT.451973 DT.97857690 DT.91661314 DT.100853589 DT.100691841

DT.100691845 DT.92458819 DT.100691852 DT.120669373 DT.120669415 DT.95202663 DT.120669428 DT.40211388

DT.120669362 DT.100691842 DT.100691847 DT.100763736 DT.91845241 DT.91878116

24/1476 AceView cDNA sequences (see all 1476 ):

BI252196 BQ684691 AW071866 BQ961643 BM557522 BE793353 BC007676 BU075681

CB140254 BC000447 BF111661 AI363384 R71917 AW246102 BE645161 BQ957590

CB156328 BX333470 AI671928 BE312186 BU556978 H23821 CA394825 AW163668

highest scoring ESTs for MIF:

AA025719 AA027224 AA027993 AA121054 AA121539 AA127849 AA143408 AA147893 AA150737 AA156617

Unigene Cluster for MIF:

Macrophage migration inhibitory factor (glycosylation-inhibiting factor)

Hs.407995 [show with all ESTs]

Unigene Representative Sequence: BQ056329

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for MIF

ExUns:	1a	·	1b	·	1c	^	2a	·	2b	^	3a	·	3b	·	3c
SP1:							-
SP2:					-		-
SP3:

About this scheme

ECgene alternative splicing isoforms for MIF

1 Ensembl transcript including schematic representation:

ENST00000215754

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

MIF expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for MIF

¹ / ² / ³

3 probe-sets matching MIF gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
895_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	L19686	0.20	1.00	0.72	1
217871_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_002415	0.60	0.83	0.73	1
217871_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: AACGCGGCCA

SOURCE GeneReport for Unigene cluster: Hs.407995
Expression variation in blood from EXPOLDB for MIF

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for MIF gene from 5/6 species (see all 6 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
cow (Bos taurus)	MIF¹	--	macrophage migration inhibitory factor (glycosylation-inhibiting more	93.62(n) 92.17(a)	280858 NM_001033608.1 NP_001028780.1
rat (Rattus norvegicus)	Mif¹	--	macrophage migration inhibitory factor	89.86(n) 90.43(a)	81683 NM_031051.1 NP_112313.1
mouse (Mus musculus)	Mif^{1, 5}	10 (40.90 cM)⁵	macrophage migration inhibitory factor^{1, 5}	88.7(n)¹ 89.57(a)¹	17319¹ NM_010798.2¹ NP_034928.1¹ AF033192⁵ AF204395⁵ (see all 24)
zebrafish (Danio rerio)	Dr.7856²	--	Danio rerio, clone IMAGE5776860, mRNA	78.1(n)	BC049029.1
African clawed frog (Xenopus laevis)	MIF²	--	macrophage migration inhibitory factor	73.19(n)	AB111063.1

About this table Species with no ortholog for MIF

ENSEMBL Gene Tree for MIF

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for MIF gene

DDT² DDTL²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/74 NCBI SNPs in MIF are shown (see all 74 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 89)

AB	SNP ID	Valid	Chr 22 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs2070767^1,2	A,C,F,H	22567463(+)	`CGGGAC/TATTGG`	1	--	ng3¹		11	EA WA NA NS	600
--	rs2012124^1,2	A,C,F,H	22564664(+)	`ggttcC/Tgaatg`	1	--	ng5¹		13	EU EA WA NS	1004
	rs2000466^1,2	C,F,H,O	22567862(+)	`AAAGAT/GCCCAC`	1	--	ng3¹		11	MN EU EA WA NS	952
	rs4822447^1,2	A,C,F,H	22565380(+)	`CTGGGA/GCTTAG`	1	--	ng5¹		6	WA NS	310
--	rs2012133^1,2	A,C,F,H	22564734(+)	`gtctcG/Cgggtt`	1	--	ng5¹		8	EU EA NS	486
	rs4822443^1,2	A,C,F,H	22565198(+)	`GTCCAG/AGCCAA`	1	--	ng5¹		14	EU EA WA NS	1186
	rs4822445^1,2	A,C,F	22565306(+)	`ATGAGG/ATGTAG`	1	--	ng5¹		5	NS	190
	rs4822446^1,2	A,C,F	22565360(+)	`CAGTCA/GGCTGC`	1	--	ng5¹		5	NS	190
--	rs12483884^1,2	C,F,H	22564935(+)	`TGTTAT/CGGTAA`	1	--	ng5¹		8	EU EA NS	460
--	rs4822448^1,2	A,C,F	22565459(+)	`GAAGGT/GGTGAC`	1	--	ng5¹		5	NS	190

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HapMap Linkage Disequilibrium images for MIF (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 153620 disorders: 604302

UniProtKB/Swiss-Prot: MIF_HUMAN, P14174

Genetic variations in MIF are associated with susceptibility to systemic juvenile

rheumatoid arthritis [MIM:604302]. Systemic juvenile rheumatoid arthritis is juvenile chronic

arthritis associated with severe, debilitating, extraarticular features, and occasionally fatal

complications. Despite medical treatment, many children still experience early joint destruction,

necessitating surgical replacement

10/93 Novoseek disease relationships for MIF gene (see all 93 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
shock septic	59.84	48	11397892 (4), 10655104 (3), 16125329 (3), 12792855 (2) (see all 26)
inflammation	53.56	79	15659324 (4), 11673308 (3), 2260882 (2), 15225126 (2) (see all 55)
rheumatoid arthritis	50.56	43	16628200 (3), 17166737 (2), 18442790 (2), 17869648 (2) (see all 31)
sepsis	50.42	87	17443469 (6), 16115897 (4), 15377884 (4), 10655104 (3) (see all 31)
necrosis	49.02	56	11377135 (2), 12480958 (1), 14621041 (1), 15037585 (1) (see all 50)
tumors	44.96	214	18171602 (7), 12925952 (6), 15973102 (5), 15064733 (5) (see all 99)
arthritis	40.52	21	18078632 (2), 11207663 (2), 16465610 (2), 12746913 (1) (see all 12)
glomerulonephritis	37.28	14	11792756 (2), 10652026 (1), 11757824 (1), 11773615 (1) (see all 12)
hypersensitivity delayed	37.19	4	18288453 (1), 11032394 (1), 2307508 (1), 15770393 (1)
systemic inflammatory response syndrome	37.05	3	16677407 (1), 17534704 (1), 11534567 (1)

About this table

Human Gene Mutation Database: MIF
Genetic Association Database: MIF
Human Genome Epidemiology Navigator: MIF (61 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/607 PubMed articles for MIF gene (see all 607 ):

A novel 5'-flanking region polymorphism of macrophage migration inhibitory factor is associated with systemic-onset juvenile idiopathic arthritis. (PubMed id 11508429)^{1, 3, 4, 6} Donn R.P.... Thomson W. (2001)
Molecular cloning of a cDNA encoding a human macrophage migration inhibitory factor. (PubMed id 2552447)^{2, 3, 4} Weiser W.Y....David J.R. (1989)
Molecular cloning and functional expression of a cDNA encoding glycosylation-inhibiting factor. (PubMed id 8234256)^{1, 3, 4} Mikayama T.... Ishii Y. (1993)
Intracellular action of the cytokine MIF to modulate AP-1 activity and the cell cycle through Jab1. (PubMed id 11089976)^{1, 3, 4} Kleemann R.... Bernhagen J. (2000)
Correlation of rheumatoid arthritis severity with the genetic functional variants and circulating levels of macrophage migration inhibitory factor. (PubMed id 16200611)^{1, 3, 6} Radstake T.R....van Riel P.L. (2005)
Polymorphisms of the macrophage inhibitory factor and C-reactive protein genes in subjects with Alzheimer's dementia. (PubMed id 15286457)^{1, 3, 6} Flex A....Pola P. (2004)
Macrophage migration inhibitory factor gene polymorphism is associated with psoriasis. (PubMed id 15304087)^{1, 3, 6} Donn R.P....Griffiths C.E. (2004)
Macrophage migration inhibitory factor gene polymorphism is associated with sarcoidosis in biopsy proven erythema nodosum. (PubMed id 12180727)^{1, 3, 6} Amoli M.M....Gonzalez-Gay M.A. (2002)
Promoter polymorphism in the macrophage migration inhibitory factor gene is associated with obesity. (PubMed id 16247506)^{1, 3, 6} Sakaue S....Nishimura M. (2006)
Proinflammatory genetic profiles in subjects with history of ischemic stroke. (PubMed id 15308783)^{1, 3, 6} Flex A....Pola R. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 4282	HGNC: 7097	AceView: MIFandSLC2A11	Ensembl:ENSG00000099964	euGenes: HUgn4282
ECgene: MIF	H-InvDB: MIF

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for MIF	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/mif/

Licensable Technologies for MIF
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for MIF:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for MIF-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for MIF		Antibodies for MIF
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for MIF		Small molecules for MIF
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
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GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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MIF Gene at Home site.
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MIF Gene

protein-coding GIFtS: 71

Aliases &
Descriptions
for MIF

Summaries
for MIF

Genomic Location
for MIF

Proteins
for MIF

Protein Domains/
Families
for MIF

Gene Function
for MIF

Pathways & Interactions
for MIF

Drugs & Compounds
for MIF

Transcripts
for MIF

Expression
for MIF

Orthologs
for MIF

Paralogs
for MIF

SNPs/Variants
for MIF

Disorders & Mutations
for MIF

Medical News
for MIF

Publications
for MIF

Search for MIF

Genome Databases showing MIF

Other Databases showing MIF

Specialized Databases showing MIF

Licensable Technologies
for MIF

Services
for MIF

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

MIF Gene

protein-coding GIFtS: 71

Aliases & Descriptionsfor MIF

Summariesfor MIF

Genomic Locationfor MIF

Proteinsfor MIF

Protein Domains/Familiesfor MIF

Gene Functionfor MIF

Pathways & Interactionsfor MIF

Drugs & Compoundsfor MIF

Transcriptsfor MIF

Expression for MIF

Orthologsfor MIF

Paralogsfor MIF

SNPs/Variantsfor MIF

Disorders & Mutationsfor MIF

Medical Newsfor MIF

Publicationsfor MIF

Search for MIF

Genome Databases showing MIF

Other Databases showing MIF

Specialized Databases showing MIF

Licensable Technologiesfor MIF

Servicesfor MIF

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for MIF

Summaries
for MIF

Genomic Location
for MIF

Proteins
for MIF

Protein Domains/
Families
for MIF

Gene Function
for MIF

Pathways & Interactions
for MIF

Drugs & Compounds
for MIF

Transcripts
for MIF

Expression
for MIF

Orthologs
for MIF

Paralogs
for MIF

SNPs/Variants
for MIF

Disorders & Mutations
for MIF

Medical News
for MIF

Publications
for MIF

Licensable Technologies
for MIF

Services
for MIF