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Aliases for MIF Gene

Aliases for MIF Gene

  • Macrophage Migration Inhibitory Factor (Glycosylation-Inhibiting Factor) 2 3 5
  • Phenylpyruvate Tautomerase 3 4
  • L-Dopachrome Tautomerase 3 4
  • L-Dopachrome Isomerase 3 4
  • GLIF 3 4
  • MMIF 3 4
  • GIF 3 4
  • Glycosylation-Inhibiting Factor 4
  • EC 5.3.3.12 4
  • EC 5.3.2.1 4

External Ids for MIF Gene

Previous HGNC Symbols for MIF Gene

  • GLIF

Previous GeneCards Identifiers for MIF Gene

  • GC22P020896
  • GC22P022560
  • GC22P022561
  • GC22P022369
  • GC22P024236
  • GC22P007221

Summaries for MIF Gene

Entrez Gene Summary for MIF Gene

  • This gene encodes a lymphokine involved in cell-mediated immunity, immunoregulation, and inflammation. It plays a role in the regulation of macrophage function in host defense through the suppression of anti-inflammatory effects of glucocorticoids. This lymphokine and the JAB1 protein form a complex in the cytosol near the peripheral plasma membrane, which may indicate an additional role in integrin signaling pathways. [provided by RefSeq, Jul 2008]

GeneCards Summary for MIF Gene

MIF (Macrophage Migration Inhibitory Factor (Glycosylation-Inhibiting Factor)) is a Protein Coding gene. Diseases associated with MIF include rheumatoid arthritis, systemic juvenile and persistent mullerian duct syndrome, type ii. Among its related pathways are Tyrosine metabolism and MIF Action Through Endocytic Pathway. GO annotations related to this gene include receptor binding and cytokine receptor binding. An important paralog of this gene is DDTL.

UniProtKB/Swiss-Prot for MIF Gene

  • Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity.

Tocris Summary for MIF Gene

  • Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation and cell survival/apoptosis but are also involved in several pathophysiological processes.

Gene Wiki entry for MIF Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIF Gene

Genomics for MIF Gene

Regulatory Elements for MIF Gene


Promoters for MIF Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MIF on UCSC Golden Path with GeneCards custom track

Genomic Location for MIF Gene

Chromosome:
22
Start:
23,894,004 bp from pter
End:
23,895,227 bp from pter
Size:
1,224 bases
Orientation:
Plus strand

Genomic View for MIF Gene

Genes around MIF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIF Gene

Proteins for MIF Gene

  • Protein details for MIF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P14174-MIF_HUMAN
    Recommended name:
    Macrophage migration inhibitory factor
    Protein Accession:
    P14174
    Secondary Accessions:
    • A5Z1R8
    • B2R4S3
    • Q2V4Y5
    • Q6FHV0

    Protein attributes for MIF Gene

    Size:
    115 amino acids
    Molecular mass:
    12476 Da
    Quaternary structure:
    • Homotrimer. Interacts with CXCR2 extracellular domain (By similarity). Interacts with the CD74 extracellular domain, COPS5 and BNIPL.
    Miscellaneous:
    • Serum levels of MIF are elevated in patients with severe sepsis or septic shock. High levels of MIF are correlated with low survival. Drugs that inhibit tautomerase activity protect against death due to sepsis.

    Three dimensional structures from OCA and Proteopedia for MIF Gene

neXtProt entry for MIF Gene

Proteomics data for MIF Gene at MOPED

Post-translational modifications for MIF Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MIF Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for MIF Gene

Domains & Families for MIF Gene

Suggested Antigen Peptide Sequences for MIF Gene

Graphical View of Domain Structure for InterPro Entry

P14174

UniProtKB/Swiss-Prot:

MIF_HUMAN :
  • Belongs to the MIF family.
Family:
  • Belongs to the MIF family.
genes like me logo Genes that share domains with MIF: view

No data available for Gene Families for MIF Gene

Function for MIF Gene

Molecular function for MIF Gene

GENATLAS Biochemistry:
macrophage migration inhibitory factor,12.3kDa,expressed in T cells and various tissues,including immunologically privileged lens and brain,also involved in mitogenic response and the control of cell cycle progression,maybe the same as DDT
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=249 uM for phenylpyruvate {ECO:0000269 PubMed:11439086}; KM=168 uM for p-hydroxyphenylpyruvate {ECO:0000269 PubMed:11439086}; Vmax=2113 umol/min/mg enzyme toward phenylpyruvate {ECO:0000269 PubMed:11439086}; Vmax=524 umol/min/mg enzyme toward p-hydroxyphenylpyruvate {ECO:0000269 PubMed:11439086};
UniProtKB/Swiss-Prot CatalyticActivity:
Keto-phenylpyruvate = enol-phenylpyruvate.
UniProtKB/Swiss-Prot CatalyticActivity:
L-dopachrome = 5,6-dihydroxyindole-2-carboxylate.
UniProtKB/Swiss-Prot Function:
Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity.
UniProtKB/Swiss-Prot Induction:
Up-regulated in concanavalin-A-treated lymphocytes. Up-regulated in macrophages upon exposure to M.tuberculosis antigens.

Enzyme Numbers (IUBMB) for MIF Gene

genes like me logo Genes that share phenotypes with MIF: view

Human Phenotype Ontology for MIF Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for MIF Gene

MGI Knock Outs for MIF:

Animal Model Products

miRNA for MIF Gene

No data available for Gene Ontology (GO) - Molecular Function , Transcription Factor Targets and HOMER Transcription for MIF Gene

Localization for MIF Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIF Gene

Secreted. Cytoplasm. Note=Does not have a cleavable signal sequence and is secreted via a specialized, non-classical pathway. Secreted by macrophages upon stimulation by bacterial lipopolysaccharide (LPS), or by M.tuberculosis antigens. {ECO:0000269 PubMed:15908412}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MIF Gene COMPARTMENTS Subcellular localization image for MIF gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 4
cytoskeleton 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for MIF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with MIF: view

Pathways & Interactions for MIF Gene

genes like me logo Genes that share pathways with MIF: view

SIGNOR curated interactions for MIF Gene

Activates:

Gene Ontology (GO) - Biological Process for MIF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001516 prostaglandin biosynthetic process IDA 12782713
GO:0001934 positive regulation of protein phosphorylation IEA --
GO:0002906 negative regulation of mature B cell apoptotic process IEA --
GO:0006954 inflammatory response IEA --
GO:0007569 cell aging IEA --
genes like me logo Genes that share ontologies with MIF: view

Drugs & Compounds for MIF Gene

(53) Drugs for MIF Gene - From: DrugBank, ClinicalTrials, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Thalidomide Approved, Investigational, Withdrawn Pharma Immunomodulatory agent,sedative drug,angiogenesis inhibitor, Immunomodulatory agents, TNF-alpha synthesis inhibitor 1043
3-(4-HYDROXYPHENYL)-4,5-DIHYDRO-5-ISOXAZOLE-ACETIC ACID METHYL ESTER Experimental Pharma Target 0
3-(4-HYDROXY-PHENYL)PYRUVIC ACID Experimental Pharma Target 0
3-FLUORO-4-HYDROXYBENZALDEHYDE O-(CYCLOHEXYLCARBONYL)OXIME Experimental Pharma Target 0
4-HYDROXYBENZALDEHYDE O-(3,3-DIMETHYLBUTANOYL)OXIME Experimental Pharma Target 0

(44) Additional Compounds for MIF Gene - From: Novoseek, HMDB, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
l-dopachrome
  • 2-L-Carboxy-2,3-dihydroindole-5,6-quinone
  • L-Dopachrome
89762-39-0
2-Hydroxy-3-(4-hydroxyphenyl)propenoic acid
  • 2-Hydroxy-3-(4-hydroxyphenyl)propenoate
  • 2-Hydroxy-3-(4-hydroxyphenyl)propenoic acid
  • 4-Hydroxy-enol-phenylpyruvate
4-Hydroxyphenylpyruvic acid
  • (p-hydroxyphenyl)-Pyruvate
  • (p-hydroxyphenyl)-Pyruvic acid
  • (p-Hydroxyphenyl)pyruvate
  • (p-Hydroxyphenyl)pyruvic acid
  • 3-(4-Hydroxyphenyl)-2-oxo-propanoate
156-39-8
5,6-Dihydroxyindole-2-carboxylic acid
  • 5,6-Dhica
  • 5,6-Dihydroxy-1H-indole-2-carboxylate
  • 5,6-Dihydroxy-1H-indole-2-carboxylic acid
  • 5,6-Dihydroxy-2-indolecarboxylate
  • 5,6-Dihydroxy-2-indolecarboxylic acid
4790-08-3
Enol-phenylpyruvate
  • 2-Hydroxy-3-phenylpropenoate
  • 2-Hydroxy-3-phenylpropenoic acid
  • Enol-alpha-ketohydrocinnamic acid
  • Enol-phenylpyruvic acid
  • Phenylpyruvate
5801-57-0

(5) Tocris Compounds for MIF Gene

Compound Action Cas Number
10Z-Hymenialdisine Pan kinase inhibitor; potently inhibits MEK1 82005-12-7
Chicago Sky Blue 6B Potent inhibitor of L-glutamate uptake into synaptic vesicles; also inhibits MIF 2610-05-1
Gabexate mesylate Serine protease inhibitor; inhibits thrombin, trypsin, kallikrein and plasmin 56974-61-9
Pirfenidone Antifibrotic agent; regulates cytokine levels in vivo 53179-13-8
Thalidomide TNF-alpha synthesis inhibitor 50-35-1
genes like me logo Genes that share compounds with MIF: view

Transcripts for MIF Gene

mRNA/cDNA for MIF Gene

Unigene Clusters for MIF Gene

Macrophage migration inhibitory factor (glycosylation-inhibiting factor):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MIF Gene

No ASD Table

Relevant External Links for MIF Gene

GeneLoc Exon Structure for
MIF
ECgene alternative splicing isoforms for
MIF

Expression for MIF Gene

mRNA expression in normal human tissues for MIF Gene

Protein differential expression in normal tissues from HIPED for MIF Gene

This gene is overexpressed in Bone (18.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MIF Gene



SOURCE GeneReport for Unigene cluster for MIF Gene Hs.407995

genes like me logo Genes that share expression patterns with MIF: view

Protein tissue co-expression partners for MIF Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MIF Gene

Orthologs for MIF Gene

This gene was present in the common ancestor of animals.

Orthologs for MIF Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MIF 35
  • 93.62 (n)
  • 92.17 (a)
MIF 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mif 35
  • 88.7 (n)
  • 89.57 (a)
Mif 16
Mif 36
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mif 35
  • 89.86 (n)
  • 90.43 (a)
oppossum
(Monodelphis domestica)
Mammalia MIF 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MIF 36
  • 78 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MIF 36
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves MIF 35
  • 75.07 (n)
  • 71.3 (a)
MIF 36
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mif 35
  • 65.51 (n)
  • 64.35 (a)
African clawed frog
(Xenopus laevis)
Amphibia MIF 35
zebrafish
(Danio rerio)
Actinopterygii Dr.7856 35
mif 35
  • 67.54 (n)
  • 69.3 (a)
mif 36
  • 69 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea mif-1 36
  • 33 (a)
OneToMany
mif-2 36
  • 27 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 27 (a)
OneToOne
Species with no ortholog for MIF:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MIF Gene

ENSEMBL:
Gene Tree for MIF (if available)
TreeFam:
Gene Tree for MIF (if available)

Paralogs for MIF Gene

Paralogs for MIF Gene

(2) SIMAP similar genes for MIF Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MIF: view

Variants for MIF Gene

Sequence variations from dbSNP and Humsavar for MIF Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs35777250 -- 23,893,043(+) CTAGG(C/T)GGTAG upstream-variant-2KB
rs35859154 -- 23,892,478(+) GTTCT(A/G)AATGT upstream-variant-2KB
rs4822443 -- 23,893,011(+) GTCCA(A/G)GCCAA upstream-variant-2KB
rs4822444 -- 23,893,116(+) GTGAT(C/G)AGGTG upstream-variant-2KB
rs4822445 -- 23,893,119(+) ATGAG(A/G)TGTAG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIF Gene

Variant ID Type Subtype PubMed ID
nsv7350 OTHER Inversion 18451855
esv2724041 CNV Deletion 23290073
nsv526567 CNV Gain 19592680
dgv4906n71 CNV Gain 21882294
nsv914599 CNV Gain 21882294
nsv511075 CNV Complex 20534489
nsv834155 CNV Gain+Loss 17160897
nsv3577 CNV Insertion 18451855
nsv914604 CNV Loss 21882294

Variation tolerance for MIF Gene

Gene Damage Index Score: 0.39; 8.64% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MIF Gene

HapMap Linkage Disequilibrium report
MIF
Human Gene Mutation Database (HGMD)
MIF

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MIF Gene

Disorders for MIF Gene

MalaCards: The human disease database

(23) MalaCards diseases for MIF Gene - From: OMIM, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
rheumatoid arthritis, systemic juvenile
  • rheumatoid arthritis systemic juvenile
persistent mullerian duct syndrome, type ii
  • persistent mullerian duct syndrome, type i
systemic onset juvenile idiopathic arthritis
  • still's disease
pulmonary hemosiderosis
  • byssinosis
arthritis
  • inflammatory disorder of joint
- elite association - COSMIC cancer census association via MalaCards
Search MIF in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

MIF_HUMAN
  • Rheumatoid arthritis systemic juvenile (RASJ) [MIM:604302]: An inflammatory articular disorder with systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis. {ECO:0000269 PubMed:11508429}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. {ECO:0000305}.

Relevant External Links for MIF

Genetic Association Database (GAD)
MIF
Human Genome Epidemiology (HuGE) Navigator
MIF
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIF
genes like me logo Genes that share disorders with MIF: view

No data available for Genatlas for MIF Gene

Publications for MIF Gene

  1. A novel 5'-flanking region polymorphism of macrophage migration inhibitory factor is associated with systemic-onset juvenile idiopathic arthritis. (PMID: 11508429) Donn R.P. … Thomson W. (Arthritis Rheum. 2001) 3 4 48 67
  2. Macrophage migration inhibitory factor is a direct target of HBP1-mediated transcriptional repression that is overexpressed in prostate cancer. (PMID: 20383199) Chen Y.C. … Mao Z.B. (Oncogene 2010) 3 23
  3. Up-regulation of cyclooxygenase-2 expression and prostaglandin E2 production in human endometriotic cells by macrophage migration inhibitory factor: involvement of novel kinase signaling pathways. (PMID: 19299454) Carli C. … Akoum A. (Endocrinology 2009) 3 23
  4. NF-kappaB inhibition leads to increased synthesis and secretion of MIF in human CD4+ T cells. (PMID: 19428548) Cho M.L. … Min J.K. (Immunol. Lett. 2009) 3 23
  5. Dual role of macrophage migration inhibitory factor (MIF) in human breast cancer. (PMID: 19602265) Verjans E. … Bernhagen J. (BMC Cancer 2009) 3 23

Products for MIF Gene

Sources for MIF Gene

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