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Aliases for MIER3 Gene

Aliases for MIER3 Gene

  • MIER Family Member 3 2 3 5
  • Mesoderm Induction Early Response 1, Family Member 3 2 3
  • Mi-Er3 3 4
  • Mesoderm Induction Early Response Protein 3 3

External Ids for MIER3 Gene

Previous GeneCards Identifiers for MIER3 Gene

  • GC05M056253
  • GC05M053187
  • GC05M056215

Summaries for MIER3 Gene

GeneCards Summary for MIER3 Gene

MIER3 (MIER Family Member 3) is a Protein Coding gene. GO annotations related to this gene include chromatin binding. An important paralog of this gene is MIER1.

UniProtKB/Swiss-Prot for MIER3 Gene

  • Transcriptional repressor.

Additional gene information for MIER3 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIER3 Gene

Genomics for MIER3 Gene

Regulatory Elements for MIER3 Gene

Enhancers for MIER3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05H057315 1.3 Ensembl ENCODE dbSUPER 44.4 -345.7 -345741 3.1 ZFP64 ZNF140 ZNF697 ZNF664 ZFHX2 ZNF791 POLR2A FOS ZNF433 MAFK MIER3 ENSG00000271828 RPL26P19 GPBP1 ACTBL2 PIR61821 GC05P057319 GC05P057318 GC05M057277
GH05H056636 1.7 FANTOM5 Ensembl ENCODE 16.7 +333.5 333460 3.5 PKNOX1 FOXA2 ZFP64 ARID4B FEZF1 ZNF2 YY1 GLIS2 SP3 SP5 MIER3 C5orf67 LINC01948 MAP3K1 ENSG00000228650
GH05H056908 1.4 ENCODE dbSUPER 19.8 +62.0 62018 3.3 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 SETD9 MIER3 ENSG00000271828 GPBP1 LOC105378980
GH05H057171 1.7 FANTOM5 ENCODE dbSUPER 15.1 -204.6 -204609 9.2 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B ENSG00000271828 GPBP1 MIER3 MAP3K1 SETD9 GC05M057277
GH05H056122 1.4 Ensembl ENCODE 16.7 +847.8 847765 3.4 MLX FEZF1 DMAP1 SLC30A9 SP3 ZC3H11A MEF2D SSRP1 ZNF610 GLIS1 SKIV2L2 MIER3 ENSG00000271828 HNRNPH1P3 RNA5SP183 DHX29 SLC38A9 ENSG00000238326 LOC101928419 LOC105378976
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIER3 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIER3 Gene

Genomic Locations for MIER3 Gene
chr5:56,919,602-56,971,675
(GRCh38/hg38)
Size:
52,074 bases
Orientation:
Minus strand
chr5:56,215,429-56,267,502
(GRCh37/hg19)

Genomic View for MIER3 Gene

Genes around MIER3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIER3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIER3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIER3 Gene

Proteins for MIER3 Gene

  • Protein details for MIER3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z3K6-MIER3_HUMAN
    Recommended name:
    Mesoderm induction early response protein 3
    Protein Accession:
    Q7Z3K6
    Secondary Accessions:
    • B4DRI9
    • B8ZZQ0
    • Q5CZI0
    • Q68CS3
    • Q6MZS7
    • Q86YG8
    • Q8NA13

    Protein attributes for MIER3 Gene

    Size:
    550 amino acids
    Molecular mass:
    61437 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH41348.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC04117.1; Type=Frameshift; Positions=9, 46, 49, 466; Evidence={ECO:0000305}; Sequence=CAD97846.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAE45951.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI56710.1; Type=Frameshift; Positions=4; Evidence={ECO:0000305};

    Alternative splice isoforms for MIER3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MIER3 Gene

Post-translational modifications for MIER3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MIER3 Gene

Domains & Families for MIER3 Gene

Gene Families for MIER3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for MIER3 Gene

Suggested Antigen Peptide Sequences for MIER3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIER3: view

No data available for UniProtKB/Swiss-Prot for MIER3 Gene

Function for MIER3 Gene

Molecular function for MIER3 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional repressor.

Phenotypes From GWAS Catalog for MIER3 Gene

Gene Ontology (GO) - Molecular Function for MIER3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0004407 NOT histone deacetylase activity IDA 28046085
genes like me logo Genes that share ontologies with MIER3: view
genes like me logo Genes that share phenotypes with MIER3: view

Animal Model Products

miRNA for MIER3 Gene

miRTarBase miRNAs that target MIER3

Clone Products

  • Addgene plasmids for MIER3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MIER3 Gene

Localization for MIER3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIER3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIER3 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MIER3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 28046085
GO:0005654 nucleoplasm IDA --
GO:0043234 protein complex IDA 28046085
genes like me logo Genes that share ontologies with MIER3: view

Pathways & Interactions for MIER3 Gene

SuperPathways for MIER3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIER3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0016575 NOT histone deacetylation IDA 28046085
genes like me logo Genes that share ontologies with MIER3: view

No data available for Pathways by source and SIGNOR curated interactions for MIER3 Gene

Drugs & Compounds for MIER3 Gene

No Compound Related Data Available

Transcripts for MIER3 Gene

Unigene Clusters for MIER3 Gene

Mesoderm induction early response 1, family member 3:
Representative Sequences:

Clone Products

  • Addgene plasmids for MIER3

Alternative Splicing Database (ASD) splice patterns (SP) for MIER3 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c
SP1: - - -
SP2: - - - -
SP3: - - - -
SP4:
SP5: -

Relevant External Links for MIER3 Gene

GeneLoc Exon Structure for
MIER3
ECgene alternative splicing isoforms for
MIER3

Expression for MIER3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIER3 Gene

Protein differential expression in normal tissues from HIPED for MIER3 Gene

This gene is overexpressed in Frontal cortex (56.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MIER3 Gene



Protein tissue co-expression partners for MIER3 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIER3 Gene:

MIER3

SOURCE GeneReport for Unigene cluster for MIER3 Gene:

Hs.657594
genes like me logo Genes that share expression patterns with MIER3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIER3 Gene

Orthologs for MIER3 Gene

This gene was present in the common ancestor of animals.

Orthologs for MIER3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MIER3 33 34
  • 99.7 (n)
dog
(Canis familiaris)
Mammalia MIER3 33 34
  • 94.23 (n)
cow
(Bos Taurus)
Mammalia MIER3 33 34
  • 93.93 (n)
rat
(Rattus norvegicus)
Mammalia Mier3 33
  • 88.85 (n)
mouse
(Mus musculus)
Mammalia Mier3 33 16 34
  • 87.93 (n)
oppossum
(Monodelphis domestica)
Mammalia MIER3 34
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MIER3 34
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 34
  • 83 (a)
OneToMany
MIER3 33
  • 81.9 (n)
-- 34
  • 77 (a)
OneToMany
-- 34
  • 65 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia MIER3 34
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mier3 33
  • 73.19 (n)
zebrafish
(Danio rerio)
Actinopterygii mier3 33 34
  • 65.15 (n)
MIER3 (2 of 2) 34
  • 61 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG1620 34
  • 23 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea T07F8.4 34
  • 26 (a)
ManyToMany
F10E7.11 34
  • 21 (a)
ManyToMany
Species where no ortholog for MIER3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MIER3 Gene

ENSEMBL:
Gene Tree for MIER3 (if available)
TreeFam:
Gene Tree for MIER3 (if available)

Paralogs for MIER3 Gene

Paralogs for MIER3 Gene

(2) SIMAP similar genes for MIER3 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with MIER3: view

Variants for MIER3 Gene

Sequence variations from dbSNP and Humsavar for MIER3 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000028732 -- 56,946,600(+) TAGCA(-/G)AATAG intron-variant
rs1000029254 -- 56,924,297(+) AACAA(A/G)TGTGT intron-variant
rs1000060002 -- 56,946,743(+) ATTAA(A/G)TTAAC intron-variant
rs1000094389 -- 56,952,271(+) GCCCG(A/C)TCGCA upstream-variant-2KB
rs1000103388 -- 56,952,774(+) CAATG(A/G)AAGTA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIER3 Gene

Variant ID Type Subtype PubMed ID
nsv950063 CNV duplication 24416366
nsv598216 CNV loss 21841781
nsv598215 CNV gain+loss 21841781
nsv598211 CNV gain 21841781
nsv598210 CNV loss 21841781
nsv1074832 CNV deletion 25765185
esv23156 CNV loss 19812545
dgv9795n54 CNV loss 21841781
dgv9794n54 CNV gain 21841781
dgv9793n54 CNV gain+loss 21841781

Variation tolerance for MIER3 Gene

Residual Variation Intolerance Score: 12.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.12; 51.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MIER3 Gene

Human Gene Mutation Database (HGMD)
MIER3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIER3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MIER3 Gene

Disorders for MIER3 Gene

Relevant External Links for MIER3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIER3

No disorders were found for MIER3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIER3 Gene

Publications for MIER3 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 60
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  4. Differential HDAC1 and 2 Recruitment by Members of the MIER Family. (PMID: 28046085) Derwish R … Gillespie LL (PloS one 2017) 3 60
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60

Products for MIER3 Gene

  • Addgene plasmids for MIER3

Sources for MIER3 Gene

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