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MIER3 Gene

protein-coding   GIFtS: 47
GCID: GC05M056215

Mesoderm Induction Early Response 1, Family Member 3

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Mesoderm Induction Early Response 1, Family Member 31 2
Mesoderm Induction Early Response Protein 32
mi-er32
Mi-er33

External Ids:    HGNC: 266781   Entrez Gene: 1669682   Ensembl: ENSG000001555457   UniProtKB: Q7Z3K63   

Export aliases for MIER3 gene to outside databases

Previous GC identifers: GC05M056253 GC05M053187


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MIER3 Gene:
MIER3 (mesoderm induction early response 1, family member 3) is a protein-coding gene. Diseases associated with MIER3 include breast cancer. GO annotations related to this gene include chromatin binding. An important paralog of this gene is MIER1.

UniProtKB/Swiss-Prot: MIER3_HUMAN, Q7Z3K6
Function: Transcriptional repressor (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000005.10  NT_034772.7  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MIER3 gene promoter:
         E2F-3a   E2F-4   E2F-5   E2F-2   FOXL1   E2F-1   E2F   Nkx6-1   FOXJ2 (long isoform)   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMIER3 promoter sequence
   Search Chromatin IP Primers for MIER3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MIER3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q11.2   Ensembl cytogenetic band:  5q11.2   HGNC cytogenetic band: 5q11.2

MIER3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MIER3 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M056215:  view genomic region     (about GC identifiers)

Start:
56,215,429 bp from pter      End:
56,267,502 bp from pter
Size:
52,074 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: MIER3_HUMAN, Q7Z3K6 (See protein sequence)
Recommended Name: Mesoderm induction early response protein 3  
Size: 550 amino acids; 61437 Da
Sequence caution: Sequence=AAH41348.2; Type=Erroneous initiation; Sequence=BAC04117.1; Type=Frameshift;
Positions=9, 46, 49, 466; Sequence=CAD97846.1; Type=Erroneous initiation; Sequence=CAE45951.2; Type=Erroneous
initiation; Sequence=CAI56710.1; Type=Frameshift; Positions=4;
Secondary accessions: B4DRI9 B8ZZQ0 Q5CZI0 Q68CS3 Q6MZS7 Q86YG8 Q8NA13
Alternative splicing: 5 isoforms:  Q7Z3K6-1   Q7Z3K6-2   Q7Z3K6-3   Q7Z3K6-4   Q7Z3K6-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MIER3: NX_Q7Z3K6

Explore proteomics data for MIER3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MIER3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_689835.3  
    ENSEMBL proteins: 
     ENSP00000370624   ENSP00000370611   ENSP00000370596   ENSP00000408076   ENSP00000386584  
     ENSP00000337027   ENSP00000400693   ENSP00000407169  

    MIER3 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for MIER3
    OriGene Custom MassSpec
    OriGene Custom Protein Services for MIER3
    GenScript Custom Purified and Recombinant Proteins Services for MIER3
    Novus Biologicals MIER3 Protein
    Novus Biologicals MIER3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MIER3

    MIER3 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for MIER3
    Novus Biologicals MIER3 Antibodies
    Abcam antibodies for MIER3
    Cloud-Clone Corp. Antibodies for MIER3
    ThermoFisher Antibody for MIER3
    LSBio Antibodies in human, mouse, rat for MIER3

    MIER3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MIER3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MIER3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MIER3
    Cloud-Clone Corp. CLIAs for MIER3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR017884 SANT_dom
     IPR001005 SANT/Myb
     IPR000949 ELM2_dom
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry Q7Z3K6

    ProtoNet protein and cluster: Q7Z3K6

    UniProtKB/Swiss-Prot: MIER3_HUMAN, Q7Z3K6
    Similarity: Contains 1 ELM2 domain
    Similarity: Contains 1 SANT domain


    MIER3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MIER3_HUMAN, Q7Z3K6
    Function: Transcriptional repressor (By similarity)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003682chromatin binding IEA--
         
    MIER3 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for MIER3:
     Decreased DCP1a protein expres  Increased S DNA content 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MIER3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MIER3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MIER3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MIER3

    miRNA
    Products:
        
    miRTarBase miRNAs that target MIER3:
    hsa-mir-27a-3p (MIRT028735), hsa-mir-331-3p (MIRT019243), hsa-mir-33a-5p (MIRT028197), hsa-mir-615-3p (MIRT040260), hsa-mir-30b-5p (MIRT023461), hsa-mir-32-5p (MIRT028273), hsa-mir-590-3p (MIRT016182), hsa-mir-128-3p (MIRT021919), hsa-mir-374b-5p (MIRT016054)

    Block miRNA regulation of human, mouse, rat MIER3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MIER3 (see all 173):
    hsa-miR-140-5p hsa-miR-106a hsa-miR-128 hsa-miR-519a hsa-miR-3916 hsa-miR-200b hsa-miR-92b hsa-miR-130b
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for MIER3
    Predesigned siRNA for gene silencing in human, mouse, rat MIER3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MIER3

    Clone
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    OriGene clones in human, mouse for MIER3 (see all 7)
    OriGene ORF clones in mouse, rat for MIER3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MIER3 (NM_152622)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MIER3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MIER3

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MIER3
    Browse ESI BIO Cell Lines and PureStem Progenitors for MIER3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MIER3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MIER3_HUMAN, Q7Z3K6: Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    MIER3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MIER3
    Interactions:

        Search GeneGlobe Interaction Network for MIER3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    Selected Interacting proteins for MIER3 (ENSP000003706114) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DMAP1ENSP000003126974STRING: ENSP00000312697
    MRGBPENSP000003595184STRING: ENSP00000359518
    SRCAPENSP000002625184STRING: ENSP00000262518
    HDAC2ENSP000003813314STRING: ENSP00000381331
    PSMA3ENSP000002164554STRING: ENSP00000216455
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--

    MIER3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MIER3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MIER3 gene: 
    NM_152622.3  

    Unigene Cluster for MIER3:

    Mesoderm induction early response 1, family member 3
    Hs.657594  [show with all ESTs]
    Unigene Representative Sequence: BX537798
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000381226(uc003jqz.1 uc003jrc.1) ENST00000381213(uc003jra.1 uc003jrd.1)
    ENST00000381199 ENST00000452157(uc003jrb.1) ENST00000409421 ENST00000336942
    ENST00000451637 ENST00000480115(uc003jre.3) ENST00000546593(uc003jrf.3)
    ENST00000440000(uc003jrg.3) ENST00000497185
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MIER3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MIER3 (see all 173):
    hsa-miR-140-5p hsa-miR-106a hsa-miR-128 hsa-miR-519a hsa-miR-3916 hsa-miR-200b hsa-miR-92b hsa-miR-130b
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MIER3
    Predesigned siRNA for gene silencing in human, mouse, rat MIER3
    Clone
    Products:
         
    OriGene clones in human, mouse for MIER3 (see all 7)
    OriGene ORF clones in mouse, rat for MIER3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MIER3 (NM_152622)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MIER3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MIER3
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for MIER3
    OriGene qSTAR qPCR primer pairs in human, mouse for MIER3
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat MIER3
      QuantiTect SYBR Green Assays in human, mouse, rat MIER3
      QuantiFast Probe-based Assays in human, mouse, rat MIER3

    Additional mRNA sequence: 

    AK002183.1 AK093273.1 AK299285.1 BC013936.1 BC041348.2 BX537798.1 BX640907.1 BX647359.1 
    BX648294.1 CR749246.1 CR749805.1 DQ656004.2 DQ656005.2 DQ656006.2 DQ656007.2 

    9 DOTS entries:

    DT.405591  DT.95263703  DT.86844926  DT.120828137  DT.91682023  DT.120828132  DT.120828174  DT.95263697 
    DT.40128277 

    Selected AceView cDNA sequences (see all 66):

    BQ434022 BC013936 BG942516 BQ959617 AK002183 AI368205 AI274135 CR749246 
    AL597168 AW780232 BM352100 CR749805 AA370176 AI304701 BX640907 BQ228451 
    BU752909 BQ022705 AK093273 BX647359 BC041348 BX537798 BM352420 CF994654 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for MIER3    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c
    SP1:                    -     -           -                                                               
    SP2:        -           -     -           -                                                               
    SP3:        -           -     -           -                                                               
    SP4:                                                                                                      
    SP5:        -                                                                                             


    ECgene alternative splicing isoforms for MIER3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MIER3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTCAGCTGCT
    MIER3 Expression
    About this image

    MIER3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MIER3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.657594
        Custom PCR Arrays for MIER3
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for MIER3
    OriGene qSTAR qPCR primer pairs in human, mouse for MIER3
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat MIER3
    QuantiTect SYBR Green Assays in human, mouse, rat MIER3
    QuantiFast Probe-based Assays in human, mouse, rat MIER3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MIER3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MIER3 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mier31 , 5 mesoderm induction early response 1, family member more1, 5 87.93(n)1
    93.42(a)1
      13 (63.36 cM)5
    2186131  NM_172593.31  NP_766181.21 
     1116861785 
    chicken
    (Gallus gallus)
    Aves MIER31 mesoderm induction early response 1, family member more 81.9(n)
    86.06(a)
      427146  XM_424736.4  XP_424736.3 
    lizard
    (Anolis carolinensis)
    Reptilia MIER36
    mesoderm induction early response 1, family member...
    85(a)
    1 ↔ 1
    2(1852221-1870124)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia mier31 mesoderm induction early response 1, family member more 73.19(n)
    74.22(a)
      493448  NM_001008085.1  NP_001008086.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mier31 mesoderm induction early response 1, family member more 65.15(n)
    66.03(a)
      560884  NM_001030149.2  NP_001025320.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG16206
    --
    23(a)
    1 → many
    2R(3381311-3383971)
    worm
    (Caenorhabditis elegans)
    Secernentea T07F8.46
    F10E7.116
    Protein F10E7.11 (F10E7.11) mRNA, complete cds
    26(a)
    21(a)
    many ↔ many
    many ↔ many
    II(7130485-7132034) WBGene00020320
    II(7120589-7121782) WBGene00017352


    ENSEMBL Gene Tree for MIER3 (if available)
    TreeFam Gene Tree for MIER3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MIER3 gene
    MIER12  MIER22  
    2 SIMAP similar genes for MIER3 using alignment to 4 protein entries:     MIER3_HUMAN (see all proteins):
    MIER1    MIER2

    MIER3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MIER3 (see all 609)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2010152121,2
    --56221870(+) CACAT-/AAAAAA 1 -- int10--------
    rs1135130621,2
    C--56221880(+) AAAAAG/AAGAAA 1 -- int11Minor allele frequency- A:0.50WA 2
    rs750224921,2
    C,F--56221892(+) GAATCT/AAGACA 1 -- int12Minor allele frequency- A:0.05WA 120
    rs8325321,2
    C,A,H--56221938(-) ggtctG/Ataatc 1 -- int112Minor allele frequency- A:0.31NA WA CSA EA 373
    rs783116301,2
    C--56222088(+) AAATTA/TAAAAC 1 -- int10--------
    rs1441653201,2
    C--56222088(+) AAATT-/AAAAAC 1 -- int10--------
    rs2003637001,2
    --56222093(+) AAAAA-/CTTTTA 1 -- int10--------
    rs119572761,2
    C,F,H--56222120(+) gcaagG/Agaata 1 -- int116Minor allele frequency- A:0.11NS EA NA 2098
    rs1142835631,2
    F--56222134(+) AGACAA/GGCCTC 1 -- int11Minor allele frequency- G:0.01NA 120
    rs1833098301,2
    --56222144(+) CAAAAC/TGGAAG 1 -- int10--------

    HapMap Linkage Disequilibrium report for MIER3 (56215429 - 56267502 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for MIER3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv23156CNV Loss19812545

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MIER3
    DNA2.0 Custom Variant and Variant Library Synthesis for MIER3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease for MIER3:    
    About MalaCards
    breast cancer


    MIER3 for disorders           About GeneDecksing


    Export disorders for MIER3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MIER3 gene, integrated from 10 sources (see all 17):
    (articles sorted by number of sources associating them with MIER3)
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    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    3. The functional interactome landscape of the human histone deacetylase family. (PubMed id 23752268)1 Joshi P....Cristea I.M. (Mol. Syst. Biol. 2013)
    4. Rat Mcs1b is concordant to the genome-wide association-identified breast cancer risk locus at human 5q11.2 and MIER3 is a candidate cancer susceptibility gene. (PubMed id 22993404)1 denDekker A.D....Samuelson D.J. (Cancer Res. 2012)
    5. Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes. (PubMed id 21258344)1 Bantscheff M....Drewes G. (Nat. Biotechnol. 2011)
    6. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    7. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (Sci. Signal. 2010)
    8. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (Sci. Signal. 2009)
    9. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    10. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 166968 HGNC: 26678 AceView: FLJ35954 Ensembl:ENSG00000155545 euGenes: HUgn166968
    ECgene: MIER3 H-InvDB: MIER3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MIER3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MIER3 gene:
    Search GeneIP for patents involving MIER3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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