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Aliases for MIER3 Gene

Aliases for MIER3 Gene

  • MIER Family Member 3 2 3
  • Mesoderm Induction Early Response 1, Family Member 3 2 3 5
  • Mi-Er3 3 4

External Ids for MIER3 Gene

Previous GeneCards Identifiers for MIER3 Gene

  • GC05M056253
  • GC05M053187
  • GC05M056215

Summaries for MIER3 Gene

GeneCards Summary for MIER3 Gene

MIER3 (MIER Family Member 3) is a Protein Coding gene. GO annotations related to this gene include chromatin binding. An important paralog of this gene is MIER2.

UniProtKB/Swiss-Prot for MIER3 Gene

  • Transcriptional repressor.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIER3 Gene

Genomics for MIER3 Gene

Regulatory Elements for MIER3 Gene

Genomic Location for MIER3 Gene

Chromosome:
5
Start:
56,919,602 bp from pter
End:
56,971,675 bp from pter
Size:
52,074 bases
Orientation:
Minus strand

Genomic View for MIER3 Gene

Genes around MIER3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIER3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIER3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIER3 Gene

Proteins for MIER3 Gene

  • Protein details for MIER3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z3K6-MIER3_HUMAN
    Recommended name:
    Mesoderm induction early response protein 3
    Protein Accession:
    Q7Z3K6
    Secondary Accessions:
    • B4DRI9
    • B8ZZQ0
    • Q5CZI0
    • Q68CS3
    • Q6MZS7
    • Q86YG8
    • Q8NA13

    Protein attributes for MIER3 Gene

    Size:
    550 amino acids
    Molecular mass:
    61437 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH41348.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC04117.1; Type=Frameshift; Positions=9, 46, 49, 466; Evidence={ECO:0000305}; Sequence=CAD97846.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAE45951.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI56710.1; Type=Frameshift; Positions=4; Evidence={ECO:0000305};

    Alternative splice isoforms for MIER3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MIER3 Gene

Proteomics data for MIER3 Gene at MOPED

Post-translational modifications for MIER3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for MIER3 Gene

Domains & Families for MIER3 Gene

Gene Families for MIER3 Gene

Protein Domains for MIER3 Gene

Suggested Antigen Peptide Sequences for MIER3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7Z3K6

UniProtKB/Swiss-Prot:

MIER3_HUMAN :
  • Contains 1 ELM2 domain.
Domain:
  • Contains 1 ELM2 domain.
  • Contains 1 SANT domain.
genes like me logo Genes that share domains with MIER3: view

Function for MIER3 Gene

Molecular function for MIER3 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional repressor.
genes like me logo Genes that share phenotypes with MIER3: view

Animal Model Products

miRNA for MIER3 Gene

miRTarBase miRNAs that target MIER3

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MIER3 Gene

Localization for MIER3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIER3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MIER3 Gene COMPARTMENTS Subcellular localization image for MIER3 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for MIER3 Gene

Pathways & Interactions for MIER3 Gene

SuperPathways for MIER3 Gene

No Data Available

Interacting Proteins for MIER3 Gene

Gene Ontology (GO) - Biological Process for MIER3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with MIER3: view

No data available for Pathways by source and SIGNOR curated interactions for MIER3 Gene

Drugs & Compounds for MIER3 Gene

No Compound Related Data Available

Transcripts for MIER3 Gene

Unigene Clusters for MIER3 Gene

Mesoderm induction early response 1, family member 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MIER3 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c
SP1: - - -
SP2: - - - -
SP3: - - - -
SP4:
SP5: -

Relevant External Links for MIER3 Gene

GeneLoc Exon Structure for
MIER3
ECgene alternative splicing isoforms for
MIER3

Expression for MIER3 Gene

mRNA expression in normal human tissues for MIER3 Gene

Protein differential expression in normal tissues from HIPED for MIER3 Gene

This gene is overexpressed in Frontal cortex (56.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MIER3 Gene



SOURCE GeneReport for Unigene cluster for MIER3 Gene Hs.657594

genes like me logo Genes that share expression patterns with MIER3: view

Protein tissue co-expression partners for MIER3 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MIER3 Gene

Orthologs for MIER3 Gene

This gene was present in the common ancestor of animals.

Orthologs for MIER3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MIER3 35
  • 93.93 (n)
  • 97.81 (a)
MIER3 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MIER3 35
  • 94.23 (n)
  • 97.63 (a)
MIER3 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mier3 35
  • 87.93 (n)
  • 93.42 (a)
Mier3 16
Mier3 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MIER3 35
  • 99.7 (n)
  • 99.82 (a)
MIER3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mier3 35
  • 88.85 (n)
  • 93.27 (a)
oppossum
(Monodelphis domestica)
Mammalia MIER3 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MIER3 36
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves MIER3 35
  • 81.9 (n)
  • 86.06 (a)
-- 36
  • 77 (a)
OneToMany
-- 36
  • 65 (a)
OneToMany
-- 36
  • 83 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia MIER3 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mier3 35
  • 73.19 (n)
  • 74.22 (a)
zebrafish
(Danio rerio)
Actinopterygii mier3 35
  • 65.15 (n)
  • 66.03 (a)
mier3 36
  • 63 (a)
OneToMany
MIER3 (2 of 2) 36
  • 61 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG1620 36
  • 23 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F10E7.11 36
  • 21 (a)
ManyToMany
T07F8.4 36
  • 26 (a)
ManyToMany
Species with no ortholog for MIER3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MIER3 Gene

ENSEMBL:
Gene Tree for MIER3 (if available)
TreeFam:
Gene Tree for MIER3 (if available)

Paralogs for MIER3 Gene

Paralogs for MIER3 Gene

(2) SIMAP similar genes for MIER3 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with MIER3: view

Variants for MIER3 Gene

Sequence variations from dbSNP and Humsavar for MIER3 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs17854108 - 56,937,637(+) TCAGA(C/T)CATCC reference, missense
VAR_037700 -
VAR_037701 -
VAR_037702 -
rs189695 -- 56,929,942(-) TCAAA(A/G)TACTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MIER3 Gene

Variant ID Type Subtype PubMed ID
esv23156 CNV Loss 19812545

Variation tolerance for MIER3 Gene

Residual Variation Intolerance Score: 12.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.12; 51.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MIER3 Gene

HapMap Linkage Disequilibrium report
MIER3
Human Gene Mutation Database (HGMD)
MIER3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MIER3 Gene

Disorders for MIER3 Gene

Relevant External Links for MIER3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIER3

No disorders were found for MIER3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIER3 Gene

Publications for MIER3 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. The functional interactome landscape of the human histone deacetylase family. (PMID: 23752268) Joshi P. … Cristea I.M. (Mol. Syst. Biol. 2013) 3
  5. Rat Mcs1b is concordant to the genome-wide association-identified breast cancer risk locus at human 5q11.2 and MIER3 is a candidate cancer susceptibility gene. (PMID: 22993404) denDekker A.D. … Samuelson D.J. (Cancer Res. 2012) 3

Products for MIER3 Gene

Sources for MIER3 Gene

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