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Aliases for MIER3 Gene

Aliases for MIER3 Gene

  • MIER Family Member 3 2 3 5
  • Mesoderm Induction Early Response 1, Family Member 3 2 3
  • Mi-Er3 3 4
  • Mesoderm Induction Early Response Protein 3 3

External Ids for MIER3 Gene

Previous GeneCards Identifiers for MIER3 Gene

  • GC05M056253
  • GC05M053187
  • GC05M056215

Summaries for MIER3 Gene

GeneCards Summary for MIER3 Gene

MIER3 (MIER Family Member 3) is a Protein Coding gene. GO annotations related to this gene include chromatin binding. An important paralog of this gene is MIER1.

UniProtKB/Swiss-Prot for MIER3 Gene

  • Transcriptional repressor.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIER3 Gene

Genomics for MIER3 Gene

Regulatory Elements for MIER3 Gene

Enhancers for MIER3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05G056892 1.7 dbSUPER 11.3 +75.6 75555 8.0 HLF CEBPB CEBPG ZNF644 GATA2 IKZF1 CEBPA HMBOX1 ZBTB33 FOS SETD9 ENSG00000237705 ENSG00000235635 MIER3 C5orf67 ENSG00000271828
GH05G056848 1.3 Ensembl ENCODE dbSUPER 9.8 +120.7 120728 4.3 ZMYM3 CEBPG BMI1 ZNF644 ZKSCAN1 FOSL1 ZNF316 RELB MAFK IKZF2 SETD9 MAP3K1 LOC105378980 LINC01948 ENSG00000235635 MIER3 C5orf67 GC05P056845 GC05P056846 ENSG00000237705
GH05G056900 1 Ensembl ENCODE 11.1 +70.8 70843 0.5 CTCF CEBPG EBF1 RAD21 RFX5 GATA3 ZNF143 SMC3 FOS MIXL1 SETD9 ENSG00000235635 MIER3 ENSG00000237705
GH05G057209 0.9 Ensembl dbSUPER 11.3 -237.8 -237826 0.2 ZNF362 RFX1 DPF2 ZFP41 CTBP1 PRDM6 GATA3 SCRT2 TARDBP CUX1 LOC105378980 SETD9 MIER3 ENSG00000235635 GPBP1 GC05M057277
GH05G056871 0.9 ENCODE dbSUPER 10.2 +99.4 99419 1.5 HDAC1 PKNOX1 CEBPG ATF2 HDAC2 ATF3 IKZF1 ZNF629 PBX2 HMBOX1 ENSG00000235635 MIER3 LINC01948 ENSG00000237705 SETD9
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIER3 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIER3 Gene

56,919,602 bp from pter
56,971,675 bp from pter
52,074 bases
Minus strand

Genomic View for MIER3 Gene

Genes around MIER3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIER3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIER3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIER3 Gene

Proteins for MIER3 Gene

  • Protein details for MIER3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Mesoderm induction early response protein 3
    Protein Accession:
    Secondary Accessions:
    • B4DRI9
    • B8ZZQ0
    • Q5CZI0
    • Q68CS3
    • Q6MZS7
    • Q86YG8
    • Q8NA13

    Protein attributes for MIER3 Gene

    550 amino acids
    Molecular mass:
    61437 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH41348.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC04117.1; Type=Frameshift; Positions=9, 46, 49, 466; Evidence={ECO:0000305}; Sequence=CAD97846.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAE45951.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI56710.1; Type=Frameshift; Positions=4; Evidence={ECO:0000305};

    Alternative splice isoforms for MIER3 Gene


neXtProt entry for MIER3 Gene

Post-translational modifications for MIER3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MIER3 Gene

Domains & Families for MIER3 Gene

Gene Families for MIER3 Gene

Protein Domains for MIER3 Gene

Suggested Antigen Peptide Sequences for MIER3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIER3: view

No data available for UniProtKB/Swiss-Prot for MIER3 Gene

Function for MIER3 Gene

Molecular function for MIER3 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional repressor.

Gene Ontology (GO) - Molecular Function for MIER3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with MIER3: view
genes like me logo Genes that share phenotypes with MIER3: view

Animal Model Products

CRISPR Products

miRNA for MIER3 Gene

miRTarBase miRNAs that target MIER3

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for MIER3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MIER3 Gene

Localization for MIER3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIER3 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIER3 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for MIER3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with MIER3: view

Pathways & Interactions for MIER3 Gene

SuperPathways for MIER3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIER3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with MIER3: view

No data available for Pathways by source and SIGNOR curated interactions for MIER3 Gene

Drugs & Compounds for MIER3 Gene

No Compound Related Data Available

Transcripts for MIER3 Gene

Unigene Clusters for MIER3 Gene

Mesoderm induction early response 1, family member 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for MIER3

Alternative Splicing Database (ASD) splice patterns (SP) for MIER3 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c
SP1: - - -
SP2: - - - -
SP3: - - - -
SP5: -

Relevant External Links for MIER3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIER3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIER3 Gene

Protein differential expression in normal tissues from HIPED for MIER3 Gene

This gene is overexpressed in Frontal cortex (56.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MIER3 Gene

Protein tissue co-expression partners for MIER3 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIER3 Gene:


SOURCE GeneReport for Unigene cluster for MIER3 Gene:

genes like me logo Genes that share expression patterns with MIER3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIER3 Gene

Orthologs for MIER3 Gene

This gene was present in the common ancestor of animals.

Orthologs for MIER3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MIER3 34 35
  • 99.7 (n)
(Canis familiaris)
Mammalia MIER3 34 35
  • 94.23 (n)
(Bos Taurus)
Mammalia MIER3 34 35
  • 93.93 (n)
(Rattus norvegicus)
Mammalia Mier3 34
  • 88.85 (n)
(Mus musculus)
Mammalia Mier3 34 16 35
  • 87.93 (n)
(Monodelphis domestica)
Mammalia MIER3 35
  • 87 (a)
(Ornithorhynchus anatinus)
Mammalia MIER3 35
  • 85 (a)
(Gallus gallus)
Aves -- 35
  • 83 (a)
MIER3 34
  • 81.9 (n)
-- 35
  • 77 (a)
-- 35
  • 65 (a)
(Anolis carolinensis)
Reptilia MIER3 35
  • 85 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mier3 34
  • 73.19 (n)
(Danio rerio)
Actinopterygii mier3 34 35
  • 65.15 (n)
MIER3 (2 of 2) 35
  • 61 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1620 35
  • 23 (a)
(Caenorhabditis elegans)
Secernentea T07F8.4 35
  • 26 (a)
F10E7.11 35
  • 21 (a)
Species where no ortholog for MIER3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MIER3 Gene

Gene Tree for MIER3 (if available)
Gene Tree for MIER3 (if available)

Paralogs for MIER3 Gene

Paralogs for MIER3 Gene

(2) SIMAP similar genes for MIER3 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with MIER3: view

Variants for MIER3 Gene

Sequence variations from dbSNP and Humsavar for MIER3 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000028732 -- 56,946,600(+) TAGCA(-/G)AATAG intron-variant
rs1000029254 -- 56,924,297(+) AACAA(A/G)TGTGT intron-variant
rs1000060002 -- 56,946,743(+) ATTAA(A/G)TTAAC intron-variant
rs1000094389 -- 56,952,271(+) GCCCG(A/C)TCGCA upstream-variant-2KB
rs1000103388 -- 56,952,774(+) CAATG(A/G)AAGTA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIER3 Gene

Variant ID Type Subtype PubMed ID
dgv9793n54 CNV gain+loss 21841781
dgv9794n54 CNV gain 21841781
dgv9795n54 CNV loss 21841781
esv23156 CNV loss 19812545
nsv1074832 CNV deletion 25765185
nsv598210 CNV loss 21841781
nsv598211 CNV gain 21841781
nsv598215 CNV gain+loss 21841781
nsv598216 CNV loss 21841781
nsv950063 CNV duplication 24416366

Variation tolerance for MIER3 Gene

Residual Variation Intolerance Score: 12.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.12; 51.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MIER3 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MIER3 Gene

Disorders for MIER3 Gene

Relevant External Links for MIER3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MIER3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIER3 Gene

Publications for MIER3 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64
  5. The functional interactome landscape of the human histone deacetylase family. (PMID: 23752268) Joshi P. … Cristea I.M. (Mol. Syst. Biol. 2013) 3 64

Products for MIER3 Gene

  • Addgene plasmids for MIER3

Sources for MIER3 Gene

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