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Aliases for MIER3 Gene

Aliases for MIER3 Gene

  • MIER Family Member 3 2 3 5
  • Mesoderm Induction Early Response 1, Family Member 3 2 3
  • Mi-Er3 3 4
  • Mesoderm Induction Early Response Protein 3 3

External Ids for MIER3 Gene

Previous GeneCards Identifiers for MIER3 Gene

  • GC05M056253
  • GC05M053187
  • GC05M056215

Summaries for MIER3 Gene

GeneCards Summary for MIER3 Gene

MIER3 (MIER Family Member 3) is a Protein Coding gene. GO annotations related to this gene include chromatin binding. An important paralog of this gene is MIER1.

UniProtKB/Swiss-Prot for MIER3 Gene

  • Transcriptional repressor.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIER3 Gene

Genomics for MIER3 Gene

Regulatory Elements for MIER3 Gene

Enhancers for MIER3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F056900 1 Ensembl ENCODE 11.1 +70.8 70778 0.6 CTCF CEBPG EBF1 RAD21 RFX5 GATA3 ZNF366 ZNF143 SMC3 MIXL1 SETD9 ENSG00000235635 MIER3 ENSG00000237705
GH05F056847 1.1 Ensembl ENCODE 9.8 +120.0 119975 9.0 PKNOX1 BMI1 THRB YY1 GATA2 ZNF366 ZNF263 HCFC1 CEBPB TBX21 SETD9 MAP3K1 LOC105378980 LINC01948 ENSG00000235635 MIER3 C5orf67 GC05P056845 GC05P056846 ENSG00000237705
GH05F057205 0.8 Ensembl 10.5 -235.0 -235026 3.0 HDAC1 ESRRA TBL1XR1 TAL1 FOSL1 ZNF766 NR2F6 ZNF548 HES1 RNF2 LOC105378980 SETD9 ENSG00000271828 MIER3 ENSG00000235635 ENSG00000237705 GPBP1 GC05M057277
GH05F057209 0.7 Ensembl 11.3 -237.7 -237726 0.4 ZNF362 RFX1 DPF2 ZFP41 CTBP1 GATA3 SCRT2 CUX1 PRDM1 SP7 LOC105378980 SETD9 MIER3 ENSG00000235635 GPBP1 GC05M057277
GH05F056871 0.7 ENCODE 10.2 +99.4 99419 1.5 HDAC1 PKNOX1 CEBPG ATF2 HDAC2 ATF3 IKZF1 PBX2 HMBOX1 TRIM24 ENSG00000235635 MIER3 LINC01948 ENSG00000237705 SETD9
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIER3 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIER3 Gene

Chromosome:
5
Start:
56,919,602 bp from pter
End:
56,971,675 bp from pter
Size:
52,074 bases
Orientation:
Minus strand

Genomic View for MIER3 Gene

Genes around MIER3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIER3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIER3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIER3 Gene

Proteins for MIER3 Gene

  • Protein details for MIER3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z3K6-MIER3_HUMAN
    Recommended name:
    Mesoderm induction early response protein 3
    Protein Accession:
    Q7Z3K6
    Secondary Accessions:
    • B4DRI9
    • B8ZZQ0
    • Q5CZI0
    • Q68CS3
    • Q6MZS7
    • Q86YG8
    • Q8NA13

    Protein attributes for MIER3 Gene

    Size:
    550 amino acids
    Molecular mass:
    61437 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH41348.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC04117.1; Type=Frameshift; Positions=9, 46, 49, 466; Evidence={ECO:0000305}; Sequence=CAD97846.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAE45951.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI56710.1; Type=Frameshift; Positions=4; Evidence={ECO:0000305};

    Alternative splice isoforms for MIER3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MIER3 Gene

Post-translational modifications for MIER3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MIER3 Gene

Domains & Families for MIER3 Gene

Gene Families for MIER3 Gene

Protein Domains for MIER3 Gene

Suggested Antigen Peptide Sequences for MIER3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7Z3K6

UniProtKB/Swiss-Prot:

MIER3_HUMAN :
  • Contains 1 ELM2 domain.
Domain:
  • Contains 1 ELM2 domain.
  • Contains 1 SANT domain.
genes like me logo Genes that share domains with MIER3: view

Function for MIER3 Gene

Molecular function for MIER3 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional repressor.

Gene Ontology (GO) - Molecular Function for MIER3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with MIER3: view
genes like me logo Genes that share phenotypes with MIER3: view

Animal Model Products

miRNA for MIER3 Gene

miRTarBase miRNAs that target MIER3

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MIER3 Gene

Localization for MIER3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIER3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIER3 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for MIER3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with MIER3: view

Pathways & Interactions for MIER3 Gene

SuperPathways for MIER3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIER3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with MIER3: view

No data available for Pathways by source and SIGNOR curated interactions for MIER3 Gene

Transcripts for MIER3 Gene

Unigene Clusters for MIER3 Gene

Mesoderm induction early response 1, family member 3:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIER3 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c
SP1: - - -
SP2: - - - -
SP3: - - - -
SP4:
SP5: -

Relevant External Links for MIER3 Gene

GeneLoc Exon Structure for
MIER3
ECgene alternative splicing isoforms for
MIER3

Expression for MIER3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIER3 Gene

Protein differential expression in normal tissues from HIPED for MIER3 Gene

This gene is overexpressed in Frontal cortex (56.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MIER3 Gene



Protein tissue co-expression partners for MIER3 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIER3 Gene:

MIER3

SOURCE GeneReport for Unigene cluster for MIER3 Gene:

Hs.657594
genes like me logo Genes that share expression patterns with MIER3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MIER3 Gene

Orthologs for MIER3 Gene

This gene was present in the common ancestor of animals.

Orthologs for MIER3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MIER3 34 35
  • 99.7 (n)
dog
(Canis familiaris)
Mammalia MIER3 34 35
  • 94.23 (n)
cow
(Bos Taurus)
Mammalia MIER3 34 35
  • 93.93 (n)
rat
(Rattus norvegicus)
Mammalia Mier3 34
  • 88.85 (n)
mouse
(Mus musculus)
Mammalia Mier3 34 16 35
  • 87.93 (n)
oppossum
(Monodelphis domestica)
Mammalia MIER3 35
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MIER3 35
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 35
  • 83 (a)
OneToMany
MIER3 34
  • 81.9 (n)
-- 35
  • 77 (a)
OneToMany
-- 35
  • 65 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia MIER3 35
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mier3 34
  • 73.19 (n)
zebrafish
(Danio rerio)
Actinopterygii mier3 34 35
  • 65.15 (n)
MIER3 (2 of 2) 35
  • 61 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG1620 35
  • 23 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea T07F8.4 35
  • 26 (a)
ManyToMany
F10E7.11 35
  • 21 (a)
ManyToMany
Species where no ortholog for MIER3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MIER3 Gene

ENSEMBL:
Gene Tree for MIER3 (if available)
TreeFam:
Gene Tree for MIER3 (if available)

Paralogs for MIER3 Gene

Paralogs for MIER3 Gene

(2) SIMAP similar genes for MIER3 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with MIER3: view

Variants for MIER3 Gene

Sequence variations from dbSNP and Humsavar for MIER3 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs10045390 -- 56,921,514(+) TACTG(C/T)GTAAA intron-variant, utr-variant-3-prime
rs10054376 -- 56,921,418(+) GCTAT(A/C)CTTCA intron-variant, utr-variant-3-prime
rs10056507 -- 56,931,150(+) GGGAA(C/T)AGCAG intron-variant
rs10061565 -- 56,928,351(+) ccatc(C/T)ttacc intron-variant, nc-transcript-variant, utr-variant-3-prime
rs1031200 -- 56,943,335(-) TTTTT(A/T)AATTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MIER3 Gene

Variant ID Type Subtype PubMed ID
nsv950063 CNV duplication 24416366
nsv598216 CNV loss 21841781
nsv598215 CNV gain+loss 21841781
nsv598211 CNV gain 21841781
nsv598210 CNV loss 21841781
nsv1074832 CNV deletion 25765185
esv23156 CNV loss 19812545
dgv9795n54 CNV loss 21841781
dgv9794n54 CNV gain 21841781
dgv9793n54 CNV gain+loss 21841781

Variation tolerance for MIER3 Gene

Residual Variation Intolerance Score: 12.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.12; 51.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MIER3 Gene

Human Gene Mutation Database (HGMD)
MIER3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIER3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MIER3 Gene

Disorders for MIER3 Gene

Relevant External Links for MIER3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIER3

No disorders were found for MIER3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIER3 Gene

Publications for MIER3 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64
  5. The functional interactome landscape of the human histone deacetylase family. (PMID: 23752268) Joshi P. … Cristea I.M. (Mol. Syst. Biol. 2013) 3 64

Products for MIER3 Gene

Sources for MIER3 Gene

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