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Aliases for MIER3 Gene

Aliases for MIER3 Gene

  • Mesoderm Induction Early Response 1, Family Member 3 2 3
  • Mi-Er3 3 4
  • Mesoderm Induction Early Response Protein 3 3

External Ids for MIER3 Gene

Previous GeneCards Identifiers for MIER3 Gene

  • GC05M056253
  • GC05M053187
  • GC05M056215

Summaries for MIER3 Gene

GeneCards Summary for MIER3 Gene

MIER3 (Mesoderm Induction Early Response 1, Family Member 3) is a Protein Coding gene. GO annotations related to this gene include chromatin binding. An important paralog of this gene is MIER2.

UniProtKB/Swiss-Prot for MIER3 Gene

  • Transcriptional repressor.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIER3 Gene

Genomics for MIER3 Gene

Regulatory Elements for MIER3 Gene

Genomic Location for MIER3 Gene

Start:
56,919,602 bp from pter
End:
56,971,675 bp from pter
Size:
52,074 bases
Orientation:
Minus strand

Genomic View for MIER3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIER3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIER3 Gene

Proteins for MIER3 Gene

  • Protein details for MIER3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z3K6-MIER3_HUMAN
    Recommended name:
    Mesoderm induction early response protein 3
    Protein Accession:
    Q7Z3K6
    Secondary Accessions:
    • B4DRI9
    • B8ZZQ0
    • Q5CZI0
    • Q68CS3
    • Q6MZS7
    • Q86YG8
    • Q8NA13

    Protein attributes for MIER3 Gene

    Size:
    550 amino acids
    Molecular mass:
    61437 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH41348.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC04117.1; Type=Frameshift; Positions=9, 46, 49, 466; Evidence={ECO:0000305}; Sequence=CAD97846.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAE45951.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI56710.1; Type=Frameshift; Positions=4; Evidence={ECO:0000305};

    Alternative splice isoforms for MIER3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MIER3 Gene

Proteomics data for MIER3 Gene at MOPED

Post-translational modifications for MIER3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MIER3 Gene

Domains for MIER3 Gene

Protein Domains for MIER3 Gene

Suggested Antigen Peptide Sequences for MIER3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7Z3K6

UniProtKB/Swiss-Prot:

MIER3_HUMAN :
  • Q7Z3K6
Domain:
  • Contains 1 ELM2 domain.
  • Contains 1 SANT domain.
genes like me logo Genes that share domains with MIER3: view

No data available for Gene Families for MIER3 Gene

Function for MIER3 Gene

Molecular function for MIER3 Gene

UniProtKB/Swiss-Prot Function: Transcriptional repressor.

Gene Ontology (GO) - Molecular Function for MIER3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003682 chromatin binding IEA --
genes like me logo Genes that share ontologies with MIER3: view
genes like me logo Genes that share phenotypes with MIER3: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for MIER3 Gene

Localization for MIER3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIER3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MIER3 Gene COMPARTMENTS Subcellular localization image for MIER3 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for MIER3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with MIER3: view

Pathways for MIER3 Gene

SuperPathways for MIER3 Gene

No Data Available

Interacting Proteins for MIER3 Gene

Gene Ontology (GO) - Biological Process for MIER3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with MIER3: view

No data available for Pathways by source for MIER3 Gene

Transcripts for MIER3 Gene

Unigene Clusters for MIER3 Gene

Mesoderm induction early response 1, family member 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MIER3 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c
SP1: - - -
SP2: - - - -
SP3: - - - -
SP4:
SP5: -

Relevant External Links for MIER3 Gene

GeneLoc Exon Structure for
MIER3
ECgene alternative splicing isoforms for
MIER3

Expression for MIER3 Gene

mRNA expression in normal human tissues for MIER3 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MIER3 Gene

SOURCE GeneReport for Unigene cluster for MIER3 Gene Hs.657594

genes like me logo Genes that share expressions with MIER3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MIER3 Gene

Orthologs for MIER3 Gene

This gene was present in the common ancestor of animals.

Orthologs for MIER3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MIER3 35
  • 99.7 (n)
  • 99.82 (a)
MIER3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MIER3 35
  • 93.93 (n)
  • 97.81 (a)
MIER3 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MIER3 35
  • 94.23 (n)
  • 97.63 (a)
MIER3 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mier3 35
  • 87.93 (n)
  • 93.42 (a)
Mier3 16
Mier3 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MIER3 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MIER3 36
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mier3 35
  • 88.85 (n)
  • 93.27 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 77 (a)
OneToMany
-- 36
  • 65 (a)
OneToMany
-- 36
  • 83 (a)
OneToMany
MIER3 35
  • 81.9 (n)
  • 86.06 (a)
lizard
(Anolis carolinensis)
Reptilia MIER3 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mier3 35
  • 73.19 (n)
  • 74.22 (a)
zebrafish
(Danio rerio)
Actinopterygii mier3 35
  • 65.15 (n)
  • 66.03 (a)
mier3 36
  • 63 (a)
OneToMany
MIER3 (2 of 2) 36
  • 61 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG1620 36
  • 23 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F10E7.11 36
  • 21 (a)
ManyToMany
T07F8.4 36
  • 26 (a)
ManyToMany
Species with no ortholog for MIER3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MIER3 Gene

ENSEMBL:
Gene Tree for MIER3 (if available)
TreeFam:
Gene Tree for MIER3 (if available)

Paralogs for MIER3 Gene

Paralogs for MIER3 Gene

Selected SIMAP similar genes for MIER3 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with MIER3: view

Variants for MIER3 Gene

Sequence variations from dbSNP and Humsavar for MIER3 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs170733 -- 56,953,424(+) ACATG(A/G)ATAAG upstream-variant-2KB
rs173762 -- 56,931,510(-) AAATT(A/G)AAATT intron-variant
rs173763 -- 56,929,591(-) AAGAA(C/T)TTGTG intron-variant
rs189695 -- 56,929,942(-) TCAAA(A/G)TACTG intron-variant
rs190412 -- 56,929,677(-) TCCTT(A/T)ATATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MIER3 Gene

Variant ID Type Subtype PubMed ID
esv23156 CNV Loss 19812545

Relevant External Links for MIER3 Gene

HapMap Linkage Disequilibrium report
MIER3
Human Gene Mutation Database (HGMD)
MIER3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MIER3 Gene

Disorders for MIER3 Gene

No disorders were found for MIER3 Gene.

No data available for UniProtKB/Swiss-Prot for MIER3 Gene

Publications for MIER3 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. From ORFeome to biology: a functional genomics pipeline. (PMID: 15489336) Wiemann S. … Poustka A. (Genome Res. 2004) 3
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. The LIFEdb database in 2006. (PMID: 16381901) Mehrle A. … Wiemann S. (Nucleic Acids Res. 2006) 3

Products for MIER3 Gene

Sources for MIER3 Gene

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