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MIER2 Gene

protein-coding   GIFtS: 46
GCID: GC19M000305

Mesoderm Induction Early Response 1, Family Member 2

(Previous name: KIAA1193)
(Previous symbol: KIAA1193)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Mesoderm Induction Early Response 1, Family Member 21 2
KIAA11931 2 3
Mi-er22 3
Mesoderm Induction Early Response Protein 22

External Ids:    HGNC: 292101   Entrez Gene: 545312   Ensembl: ENSG000001055567   UniProtKB: Q8N3443   

Export aliases for MIER2 gene to outside databases

Previous GC identifers: GC19M000257 GC19M000079


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MIER2 Gene:
MIER2 (mesoderm induction early response 1, family member 2) is a protein-coding gene. GO annotations related to this gene include chromatin binding. An important paralog of this gene is MIER3.

UniProtKB/Swiss-Prot: MIER2_HUMAN, Q8N344
Function: Transcriptional repressor (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011295.12  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MIER2 gene promoter:
         HFH-3   NF-1/L   NF-1   NRSF form 1   Nkx5-1   NRSF form 2   FOXI1   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMIER2 promoter sequence
   Search Chromatin IP Primers for MIER2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MIER2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

MIER2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MIER2 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M000305:  view genomic region     (about GC identifiers)

Start:
305,575 bp from pter      End:
344,798 bp from pter
Size:
39,224 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MIER2_HUMAN, Q8N344 (See protein sequence)
Recommended Name: Mesoderm induction early response protein 2  
Size: 545 amino acids; 59944 Da
Subunit: Part of a complex containing at least CDYL, MIER1, MIER2, HDAC1 and HDAC2
Sequence caution: Sequence=BAA86507.2; Type=Erroneous translation; Note=Wrong choice of frame;
Secondary accessions: Q9ULM7

Explore the universe of human proteins at neXtProt for MIER2: NX_Q8N344

Explore proteomics data for MIER2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MIER2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060020.1  
    ENSEMBL proteins: 
     ENSP00000264819  

    MIER2 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for MIER2

     
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    LSBio Antibodies in human, mouse, rat for MIER2

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    Cloud-Clone Corp. ELISAs for MIER2
    Cloud-Clone Corp. CLIAs for MIER2
    Search eBioscience for ELISAs for MIER2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR017884 SANT_dom
     IPR001005 SANT/Myb
     IPR000949 ELM2_dom
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry Q8N344

    ProtoNet protein and cluster: Q8N344

    UniProtKB/Swiss-Prot: MIER2_HUMAN, Q8N344
    Similarity: Contains 1 ELM2 domain
    Similarity: Contains 1 SANT domain


    Find genes that share domains with MIER2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MIER2_HUMAN, Q8N344
    Function: Transcriptional repressor (By similarity)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003682chromatin binding IEA--
         
    Find genes that share ontologies with MIER2           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MIER2
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    miRNA
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    miRTarBase miRNAs that target MIER2:
    hsa-mir-106b-5p (MIRT044345), hsa-mir-423-5p (MIRT038143), hsa-let-7b-5p (MIRT051939)

    Block miRNA regulation of human, mouse, rat MIER2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MIER2 (see all 43):
    hsa-miR-607 hsa-miR-513a-5p hsa-miR-106a hsa-miR-3616-5p hsa-miR-128 hsa-miR-30d hsa-miR-675 hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidMIER2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MIER2
    Predesigned siRNA for gene silencing in human, mouse, rat MIER2

    Gene Editing
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    Clone
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    OriGene ORF clones in mouse, rat for MIER2
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    GenScript: all cDNA clones in your preferred vector: MIER2 (NM_017550)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MIER2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MIER2

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MIER2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MIER2_HUMAN, Q8N344: Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    Find genes that share ontologies with MIER2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MIER2
    Interactions:

        Search GeneGlobe Interaction Network for MIER2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    Selected Interacting proteins for MIER2 (ENSP000002648194) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDYLENSP000003807184STRING: ENSP00000380718
    HDAC2ENSP000003813314STRING: ENSP00000381331
    DMAP1ENSP000003126974STRING: ENSP00000312697
    MRGBPENSP000003595184STRING: ENSP00000359518
    PSMA3ENSP000002164554STRING: ENSP00000216455
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--

    Find genes that share ontologies with MIER2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MIER2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MIER2 gene: 
    NM_017550.1  

    Unigene Cluster for MIER2:

    Mesoderm induction early response 1, family member 2
    Hs.101891  [show with all ESTs]
    Unigene Representative Sequence: AB033019
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000264819(uc002lok.1) ENST00000586994 ENST00000592722 ENST00000587966

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MIER2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MIER2 (see all 43):
    hsa-miR-607 hsa-miR-513a-5p hsa-miR-106a hsa-miR-3616-5p hsa-miR-128 hsa-miR-30d hsa-miR-675 hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidMIER2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MIER2
    Predesigned siRNA for gene silencing in human, mouse, rat MIER2
    Clone
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    OriGene clones in human, mouse for MIER2 (see all 6)
    OriGene ORF clones in mouse, rat for MIER2
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    GenScript: all cDNA clones in your preferred vector: MIER2 (NM_017550)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MIER2
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for MIER2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MIER2
      QuantiTect SYBR Green Assays in human, mouse, rat MIER2
      QuantiFast Probe-based Assays in human, mouse, rat MIER2

    Additional mRNA sequence: 

    AB033019.1 BC028203.1 

    3 DOTS entries:

    DT.309850  DT.86847608  DT.121488960 

    Selected AceView cDNA sequences (see all 325):

    AA044400 BQ918004 CD513328 BM982162 BU170647 AF047760 AI147521 AL555030 
    BU183471 BF363048 BU147241 BQ961671 BX425373 BM674085 BU689968 BU623011 
    BQ924438 BC002806 BM794552 AI539020 BC028203 BG033354 BQ943796 BE745983 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for MIER2    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b
    SP1:                          -                                                                     
    SP2:                                                                                                
    SP3:                                                                    -                           


    ECgene alternative splicing isoforms for MIER2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MIER2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGACCTCAG
    MIER2 Expression
    About this image

    MIER2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MIER2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.101891
        Custom PCR Arrays for MIER2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MIER2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MIER2 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mier21 , 5 mesoderm induction early response 1, family member more1, 5 80.98(n)1
    82.16(a)1
      10 (39.72 cM)5
    704271  NM_027422.21  NP_081698.21 
     795402455 
    chicken
    (Gallus gallus)
    Aves MIER21 mesoderm induction early response 1, family member more 68.64(n)
    68.7(a)
      770192  XM_004948784.1  XP_004948841.1 
    lizard
    (Anolis carolinensis)
    Reptilia MIER26
    mesoderm induction early response 1, family member...
    50(a)
    1 ↔ 1
    GL344720.1(768-3203)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.35902 Transcribed sequences 76.08(n)    CF375262.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5647231 mesoderm induction early response protein 2-like 58.79(n)
    54.24(a)
      564723  XM_688054.6  XP_693146.5 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG16206
    --
    19(a)
    1 → many
    2R(3381311-3383971)
    worm
    (Caenorhabditis elegans)
    Secernentea F10E7.116
    T07F8.46
    Protein T07F8.4 (T07F8.4) mRNA, complete cds
    24(a)
    22(a)
    many ↔ many
    many ↔ many
    II(7120589-7121782) WBGene00017352
    II(7130485-7132034) WBGene00020320


    ENSEMBL Gene Tree for MIER2 (if available)
    TreeFam Gene Tree for MIER2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MIER2 gene
    MIER32  MIER12  
    2 SIMAP similar genes for MIER2 using alignment to 1 protein entry:     MIER2_HUMAN:
    MIER1    MIER3

    Find genes that share paralogs with MIER2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MIER2 (see all 1345)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1460658381,2
    --305108(+) CAAAAC/GAAAAA 1 -- int10--------
    rs1399982431,2
    --305218(+) CTTCTA/CCTGGA 1 -- int10--------
    rs1457873111,2
    --305238(+) CTCTGA/TCCTCT 1 -- int10--------
    rs784834201,2
    F--305333(+) ACTTCT/CAGGAG 1 -- int11Minor allele frequency- C:0.06EA 120
    rs1489499491,2
    --305424(+) CAATAC/TGTAGC 1 -- int10--------
    rs1836668901,2
    --305430(+) GTAGCC/TCACCA 1 -- int10--------
    rs1891062331,2
    --305460(+) CCCCTC/TGCCCG 1 -- int10--------
    rs1922039841,2
    --305638(+) CTTCAA/CAGTGT 1 -- ut310--------
    rs1829710301,2
    --305706(+) GAGGCC/TGGACG 1 -- ut310--------
    rs1426358781,2
    --305728(+) AGGGCA/GCGCCG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for MIER2 (305575 - 344798 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for MIER2 (see all 18):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2666359CNV Deletion23128226
    esv2016015CNV Deletion18987734
    esv2660556CNV Deletion23128226
    esv1399571CNV Deletion17803354
    esv2422333CNV Duplication17116639
    nsv910083CNV Loss21882294
    dgv3497n71CNV Loss21882294
    dgv3496n71CNV Loss21882294
    dgv3498n71CNV Loss21882294
    nsv910077CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MIER2
    DNA2.0 Custom Variant and Variant Library Synthesis for MIER2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MIER2 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with MIER2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10574462)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 1999)
    2. The functional interactome landscape of the human histone deacetylase family. (PubMed id 23752268)1 Joshi P....Cristea I.M. (Mol. Syst. Biol. 2013)
    3. Prognostic implications of genetic variants in advanced non-small cell lung cancer: a genome-wide association study. (PubMed id 23144319)1 Lee Y....Lee J.S. (Carcinogenesis 2013)
    4. Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes. (PubMed id 21258344)1 Bantscheff M....Drewes G. (Nat. Biotechnol. 2011)
    5. CDYL bridges REST and histone methyltransferases for gene repression and suppression of cellular transformation. (PubMed id 19061646)2 Mulligan P....Shi Y. (Mol. Cell 2008)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 54531 HGNC: 29210 AceView: PPAP2CandKIAA1193 Ensembl:ENSG00000105556 euGenes: HUgn54531
    ECgene: MIER2 H-InvDB: MIER2

    (According to HUGE)
    About This Section

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    HUGE: KIAA1193

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MIER2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MIER2 gene:
    Search GeneIP for patents involving MIER2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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