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Aliases for MIER2 Gene

Aliases for MIER2 Gene

  • Mesoderm Induction Early Response 1, Family Member 2 2 3
  • KIAA1193 2 3 4
  • Mi-Er2 3 4
  • Mesoderm Induction Early Response Protein 2 3

External Ids for MIER2 Gene

Previous HGNC Symbols for MIER2 Gene

  • KIAA1193

Previous GeneCards Identifiers for MIER2 Gene

  • GC19M000257
  • GC19M000079

Summaries for MIER2 Gene

GeneCards Summary for MIER2 Gene

MIER2 (Mesoderm Induction Early Response 1, Family Member 2) is a Protein Coding gene. GO annotations related to this gene include chromatin binding. An important paralog of this gene is MIER1.

UniProtKB/Swiss-Prot for MIER2 Gene

  • Transcriptional repressor.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIER2 Gene

Genomics for MIER2 Gene

Regulatory Elements for MIER2 Gene

Genomic Location for MIER2 Gene

Start:
305,573 bp from pter
End:
344,807 bp from pter
Size:
39,235 bases
Orientation:
Minus strand

Genomic View for MIER2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIER2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIER2 Gene

Proteins for MIER2 Gene

  • Protein details for MIER2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N344-MIER2_HUMAN
    Recommended name:
    Mesoderm induction early response protein 2
    Protein Accession:
    Q8N344
    Secondary Accessions:
    • Q9ULM7

    Protein attributes for MIER2 Gene

    Size:
    545 amino acids
    Molecular mass:
    59944 Da
    Quaternary structure:
    • Part of a complex containing at least CDYL, MIER1, MIER2, HDAC1 and HDAC2.
    SequenceCaution:
    • Sequence=BAA86507.2; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305};

neXtProt entry for MIER2 Gene

Proteomics data for MIER2 Gene at MOPED

Post-translational modifications for MIER2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MIER2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MIER2 Gene

Domains for MIER2 Gene

Protein Domains for MIER2 Gene

Suggested Antigen Peptide Sequences for MIER2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N344

UniProtKB/Swiss-Prot:

MIER2_HUMAN :
  • Q8N344
Domain:
  • Contains 1 ELM2 domain.
  • Contains 1 SANT domain.
genes like me logo Genes that share domains with MIER2: view

No data available for Gene Families for MIER2 Gene

Function for MIER2 Gene

Molecular function for MIER2 Gene

UniProtKB/Swiss-Prot Function: Transcriptional repressor.

Gene Ontology (GO) - Molecular Function for MIER2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003682 chromatin binding IEA --
genes like me logo Genes that share ontologies with MIER2: view

miRNA for MIER2 Gene

miRTarBase miRNAs that target MIER2

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for MIER2 Gene

Localization for MIER2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIER2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MIER2 Gene COMPARTMENTS Subcellular localization image for MIER2 gene
Compartment Confidence
nucleus 3
cytosol 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for MIER2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with MIER2: view

Pathways for MIER2 Gene

SuperPathways for MIER2 Gene

No Data Available

Interacting Proteins for MIER2 Gene

Gene Ontology (GO) - Biological Process for MIER2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with MIER2: view

No data available for Pathways by source for MIER2 Gene

Transcripts for MIER2 Gene

Unigene Clusters for MIER2 Gene

Mesoderm induction early response 1, family member 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MIER2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b
SP1: -
SP2:
SP3: -

Relevant External Links for MIER2 Gene

GeneLoc Exon Structure for
MIER2
ECgene alternative splicing isoforms for
MIER2

Expression for MIER2 Gene

mRNA expression in normal human tissues for MIER2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MIER2 Gene

SOURCE GeneReport for Unigene cluster for MIER2 Gene Hs.101891

genes like me logo Genes that share expressions with MIER2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MIER2 Gene

Orthologs for MIER2 Gene

This gene was present in the common ancestor of animals.

Orthologs for MIER2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC455527 35
  • 86.78 (n)
  • 83.75 (a)
MIER2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MIER2 35
  • 82.51 (n)
  • 82.57 (a)
MIER2 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MIER2 35
  • 85.2 (n)
  • 84.22 (a)
MIER2 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mier2 35
  • 80.98 (n)
  • 82.16 (a)
Mier2 16
Mier2 36
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MIER2 36
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 45 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Mier2 35
  • 82.41 (n)
  • 84.42 (a)
chicken
(Gallus gallus)
Aves MIER2 35
  • 68.64 (n)
  • 68.7 (a)
MIER2 36
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MIER2 36
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.3590 35
zebrafish
(Danio rerio)
Actinopterygii LOC564723 35
  • 58.79 (n)
  • 54.24 (a)
mier2 36
  • 43 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG1620 36
  • 19 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F10E7.11 36
  • 24 (a)
ManyToMany
T07F8.4 36
  • 22 (a)
ManyToMany
Species with no ortholog for MIER2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MIER2 Gene

ENSEMBL:
Gene Tree for MIER2 (if available)
TreeFam:
Gene Tree for MIER2 (if available)

Paralogs for MIER2 Gene

Paralogs for MIER2 Gene

Selected SIMAP similar genes for MIER2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MIER2: view

Variants for MIER2 Gene

Sequence variations from dbSNP and Humsavar for MIER2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs731804 -- 327,683(-) CTAGC(C/T)TTAAC intron-variant
rs878685 -- 339,675(+) atgga(C/T)gcacc intron-variant
rs878686 -- 339,812(+) ctggg(A/G)gttga intron-variant
rs882572 -- 340,700(-) TGTAC(A/G)TTGCT intron-variant
rs895346 -- 335,267(+) GGGCA(C/G)GAGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MIER2 Gene

Variant ID Type Subtype PubMed ID
dgv1054e1 CNV Complex 17122850
nsv428360 CNV Gain 18775914
nsv833702 CNV Loss 17160897
esv2422333 CNV Duplication 17116639
nsv910072 CNV Gain 21882294
dgv3496n71 CNV Loss 21882294
dgv3497n71 CNV Loss 21882294
nsv910077 CNV Loss 21882294
dgv3498n71 CNV Loss 21882294
nsv910081 CNV Loss 21882294
nsv9656 CNV Gain 18304495
nsv138180 CNV Loss 16902084
nsv9659 CNV Gain 18304495
esv2666359 CNV Deletion 23128226
esv2016015 CNV Deletion 18987734
esv2660556 CNV Deletion 23128226
esv1399571 CNV Deletion 17803354
nsv910083 CNV Loss 21882294

Relevant External Links for MIER2 Gene

HapMap Linkage Disequilibrium report
MIER2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MIER2 Gene

Disorders for MIER2 Gene

No disorders were found for MIER2 Gene.

No data available for UniProtKB/Swiss-Prot for MIER2 Gene

Publications for MIER2 Gene

  1. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10574462) Nagase T. … Ohara O. (DNA Res. 1999) 2 3 4
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  3. Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes. (PMID: 21258344) Bantscheff M. … Drewes G. (Nat. Biotechnol. 2011) 3
  4. Prognostic implications of genetic variants in advanced non-small cell lung cancer: a genome-wide association study. (PMID: 23144319) Lee Y. … Lee J.S. (Carcinogenesis 2013) 3
  5. The functional interactome landscape of the human histone deacetylase family. (PMID: 23752268) Joshi P. … Cristea I.M. (Mol. Syst. Biol. 2013) 3

Products for MIER2 Gene

Sources for MIER2 Gene

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