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MIER1 Gene

protein-coding   GIFtS: 48
GCID: GC01P067390

Mesoderm Induction Early Response 1, Transcriptional Regulator

(Previous name: mesoderm induction early response 1 homolog (Xenopus laevis))
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Mesoderm Induction Early Response 1, Transcriptional Regulator1 2     Er13
Mesoderm Induction Early Response 1 Homolog (Xenopus Laevis)1     KIAA16103
ER12     Mi-er13
MI-ER12     Early Response 13
Mesoderm Induction Early Response 1 Homolog2     hMi-er13
Mesoderm Induction Early Response Protein 12     

External Ids:    HGNC: 296571   Entrez Gene: 577082   Ensembl: ENSG000001981607   UniProtKB: Q8N1083   

Export aliases for MIER1 gene to outside databases

Previous GC identifers: GC01P067103 GC01P065499


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MIER1 Gene:
This gene encodes a protein that was first identified in Xenopus laevis by its role in a mesoderm induction early
response (MIER). The encoded protein functions as a transcriptional regulator. Alternatively spliced transcript
variants encode multiple isoforms, some of which lack a C-terminal nuclear localization signal. (provided by
RefSeq, May 2013)

GeneCards Summary for MIER1 Gene:
MIER1 (mesoderm induction early response 1, transcriptional regulator) is a protein-coding gene. GO annotations related to this gene include chromatin binding and signal transducer activity. An important paralog of this gene is MIER3.

UniProtKB/Swiss-Prot: MIER1_HUMAN, Q8N108
Function: Transcriptional repressor regulating the expression of a number of genes including SP1 target genes.
Probably functions through recruitment of HDAC1 a histone deacetylase involved in chromatin silencing

Gene Wiki entry for MIER1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MIER1 gene promoter:
         AML1a   FOXF2   Ik-2   FOXO3a   FOXO3   STAT5A   FOXO3b   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMIER1 promoter sequence
   Search Chromatin IP Primers for MIER1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MIER1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p31.3   Ensembl cytogenetic band:  1p31.3   HGNC cytogenetic band: 1p31.2

MIER1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MIER1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P067390:  view genomic region     (about GC identifiers)

Start:
67,390,578 bp from pter      End:
67,454,302 bp from pter
Size:
63,725 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: MIER1_HUMAN, Q8N108 (See protein sequence)
Recommended Name: Mesoderm induction early response protein 1  
Size: 512 amino acids; 57983 Da
Subunit: Interacts with HDAC1. Part of a complex containing at least CDYL, MIER1, MIER2, HDAC1 and HDAC2
Sequence caution: Sequence=AAH17423.1; Type=Miscellaneous discrepancy; Note=Wrong choice of CDS. Probable cloning
artifact due to reverse transcription from RNA internal poly-A tracts; Sequence=AAM76041.1; Type=Erroneous
initiation; Note=Translation N-terminally extended; Sequence=AAM97500.1; Type=Erroneous initiation;
Note=Translation N-terminally extended; Sequence=AAM97503.1; Type=Erroneous initiation; Note=Translation
N-terminally extended; Sequence=AAM97506.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAC11339.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA. C-terminal is identical to the product
of the WLS gene; Sequence=CAD89921.1; Type=Miscellaneous discrepancy; Note=Wrong choice of CDS;
Secondary accessions: C9JFD4 Q08AE0 Q32NC4 Q5T104 Q5TAD2 Q5TAD4 Q5TAD5 Q6AHY8 Q86TB4 Q8N156
Q8N161 Q8NC37 Q8NES4 Q8NES5 Q8NES6 Q8WWG2 Q9HCG2
Alternative splicing: 9 isoforms:  Q8N108-11   Q8N108-12   Q8N108-13   Q8N108-14   Q8N108-15   Q8N108-16   Q8N108-17   Q8N108-18   
Q8N108-19   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MIER1: NX_Q8N108

Explore proteomics data for MIER1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MIER1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (11 alternative transcripts): 
    NP_001071168.2  NP_001071169.1  NP_001071170.2  NP_001071171.2  NP_001071172.1  NP_001139582.1  NP_001139583.1  NP_001139584.1  
    NP_001139585.1  NP_001265144.1  NP_065999.2  

    ENSEMBL proteins: 
     ENSP00000350321   ENSP00000383820   ENSP00000360055   ENSP00000360053   ENSP00000360051  
     ENSP00000383821   ENSP00000347514   ENSP00000360057   ENSP00000348253  

    MIER1 Human Recombinant Protein Products:

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    Novus Biologicals MIER1 Protein
    Novus Biologicals MIER1 Lysate
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    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MIER1

     
    Search eBioscience for Proteins for MIER1 

     
    antibodies-online proteins for MIER1 (6 products) 

     
    antibodies-online peptides for MIER1

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    antibodies-online antibodies for MIER1 (14 products) 

    MIER1 Assay Products:

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    Cloud-Clone Corp. ELISAs for MIER1
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    antibodies-online kits for MIER1 (15 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR017884 SANT_dom
     IPR001005 SANT/Myb
     IPR000949 ELM2_dom
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry Q8N108

    ProtoNet protein and cluster: Q8N108

    UniProtKB/Swiss-Prot: MIER1_HUMAN, Q8N108
    Similarity: Contains 1 ELM2 domain
    Similarity: Contains 1 SANT domain


    Find genes that share domains with MIER1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MIER1_HUMAN, Q8N108
    Function: Transcriptional repressor regulating the expression of a number of genes including SP1 target genes.
    Probably functions through recruitment of HDAC1 a histone deacetylase involved in chromatin silencing

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003682chromatin binding IEA--
    GO:0004871signal transducer activity IMP12761501
    GO:0005515protein binding IPI12482978
         
    Find genes that share ontologies with MIER1           About GenesLikeMe


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Mier1):
     cellular  growth/size/body  hematopoietic system  homeostasis/metabolism  immune system 

    Find genes that share phenotypes with MIER1           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for MIER1

    miRNA
    Products:
        
    miRTarBase miRNAs that target MIER1:
    hsa-mir-30e-5p (MIRT044128), hsa-mir-1 (MIRT024096)

    Block miRNA regulation of human, mouse, rat MIER1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MIER1 (see all 118):
    hsa-miR-548j hsa-miR-520f hsa-miR-3607-3p hsa-miR-607 hsa-miR-300 hsa-miR-3146 hsa-miR-200a hsa-miR-3653
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 10): MIER1 (NM_001146112)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MIER1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MIER1

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MIER1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MIER1_HUMAN, Q8N108: Isoform 1: Nucleus
    MIER1_HUMAN, Q8N108: Isoform 2: Nucleus
    MIER1_HUMAN, Q8N108: Isoform 3: Nucleus
    MIER1_HUMAN, Q8N108: Isoform 4: Cytoplasm
    MIER1_HUMAN, Q8N108: Isoform 5: Cytoplasm
    MIER1_HUMAN, Q8N108: Isoform 6: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IEA--
    GO:0017053transcriptional repressor complex IDA12482978

    Find genes that share ontologies with MIER1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MIER1
    Interactions:

        Search GeneGlobe Interaction Network for MIER1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 21)

    Selected Interacting proteins for MIER1 (Q8N1081, 2, 3 ENSP000003475144) via UniProtKB, MINT, STRING, and/or I2D (see all 25)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HDAC1Q135471, 2, 3, ENSP000003626494EBI-3504940,EBI-301834 MINT-6613715 I2D: score=1 STRING: ENSP00000362649
    CREBBPQ927933, ENSP000002623674I2D: score=1 STRING: ENSP00000262367
    HDAC2Q927692, ENSP000003813314MINT-6613715 STRING: ENSP00000381331
    ENSG00000227333Q96KQ72, ENSP000003973234MINT-6613715 STRING: ENSP00000397323
    EHMT2Q96KQ72, ENSP000003646874MINT-6613715 STRING: ENSP00000364687
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0007165signal transduction IMP12761501
    GO:0031937positive regulation of chromatin silencing IDA12482978
    GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling IMP12761501

    Find genes that share ontologies with MIER1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MIER1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MIER1 gene (11 alternative transcripts): 
    NM_001077700.2  NM_001077701.2  NM_001077702.2  NM_001077703.2  NM_001077704.2  NM_001146110.1  NM_001146111.1  NM_001146112.1  
    NM_001146113.1  NM_001278215.1  NM_020948.3  

    Unigene Cluster for MIER1:

    Mesoderm induction early response 1 homolog (Xenopus laevis)
    Hs.605432  [show with all ESTs]
    Unigene Representative Sequence: NM_001146110
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000357692(uc010opg.1 uc001ddf.2 uc001ddg.2 uc001dde.2)
    ENST00000401041 ENST00000371016 ENST00000371014 ENST00000371012(uc001dda.4)
    ENST00000401042 ENST00000355356(uc001ddj.1) ENST00000479067 ENST00000493357
    ENST00000371018(uc010opf.1 uc009way.2 uc001ddc.2 uc001ddi.2)
    ENST00000355977(uc001ddh.2)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate MIER1 (see all 118):
    hsa-miR-548j hsa-miR-520f hsa-miR-3607-3p hsa-miR-607 hsa-miR-300 hsa-miR-3146 hsa-miR-200a hsa-miR-3653
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      QuantiTect SYBR Green Assays in human, mouse, rat MIER1
      QuantiFast Probe-based Assays in human, mouse, rat MIER1

    Additional mRNA sequence: 

    AB046830.1 AF515446.1 AF515447.1 AF515448.2 AK302061.1 AK307717.1 AL831987.2 AY124186.2 
    AY124187.1 AY124188.1 AY124189.2 AY124190.1 AY124191.1 AY124192.2 AY124193.1 AY124194.1 
    BC017423.1 BC066898.1 BC108726.1 BC125217.1 BC125218.1 CR627441.1 

    18 DOTS entries:

    DT.100030282  DT.95368493  DT.99951323  DT.212024  DT.309342  DT.99938251  DT.121437523  DT.100030276 
    DT.121437559  DT.121437573  DT.92429005  DT.95186634  DT.100655492  DT.100693061  DT.40214528  DT.95153622 
    DT.40279446  DT.92429006 

    Selected AceView cDNA sequences (see all 126):

    BU753472 AA677367 BQ228058 BU660756 AA761122 AY124191 AY124189 AL598815 
    BF448834 BM806315 AY124188 CR605430 BQ286068 AY124190 AA383632 AI865459 
    AA349598 AI810073 AA745504 AA730241 BQ022768 NM_020948 AF515446 BM968413 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MIER1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    MIER1 Expression
    About this image


    MIER1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Limb (Muscoskeletal System)
             Limb Bud
    MIER1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MIER1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.605432

    UniProtKB/Swiss-Prot: MIER1_HUMAN, Q8N108
    Tissue specificity: Ubiquitously expressed, but at very low levels. However, consistent level of expression are
    observed in heart, testis, thyroid, ovary and adrenal gland. Transcripts are up-regulated in breast carcinoma
    cell lines and tumor

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MIER1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MIER1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mier11 , 5 mesoderm induction early response 1 homolog (Xenopus more1, 5 90.59(n)1
    93.37(a)1
      4 (47.36 cM)5
    711481  NM_027696.31  NP_081972.21 
     1031143905 
    chicken
    (Gallus gallus)
    Aves MIER16
    Gallus gallus mesoderm induction early response 1 ...
    83(a)
    1 ↔ 1
    8(27487798-27516244)
    lizard
    (Anolis carolinensis)
    Reptilia MIER16
    mesoderm induction early response 1, transcription...
    83(a)
    1 ↔ 1
    GL343410.1(139208-169989)
    African clawed frog
    (Xenopus laevis)
    Amphibia mi-er1-prov2 mesoderm induction early response 1 78.88(n)    BC055961.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb30a022 wufb30a02 74.93(n)   321690  BC045973.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG16206
    --
    21(a)
    1 → many
    2R(3381311-3383971)
    worm
    (Caenorhabditis elegans)
    Secernentea T07F8.46
    F10E7.116
    Protein F10E7.11 (F10E7.11) mRNA, complete cds
    26(a)
    26(a)
    many ↔ many
    many ↔ many
    II(7130485-7132034) WBGene00020320
    II(7120589-7121782) WBGene00017352


    ENSEMBL Gene Tree for MIER1 (if available)
    TreeFam Gene Tree for MIER1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MIER1 gene
    MIER32  MIER22  
    2 SIMAP similar genes for MIER1 using alignment to 4 protein entries:     MIER1_HUMAN (see all proteins):
    MIER3    MIER2

    Find genes that share paralogs with MIER1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MIER1 (see all 1211)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs680012651,2
    C--65519653(+) ATATA-/TATATATATATATATATATA/TAT
    ATATATATATATATATATATATATATA
    AAATA
    11 -- int11NA 2
    rs560127761,2
    C--65527965(+) TTTTT-/A/TAATAT 10 -- int10--------
    rs348392621,2
    C--67400088(+) TTTTTT/-GAGAC 11 -- int12Minor allele frequency- -:0.25NA 4
    rs2010448401,2
    C--67400088(+) TCTTTC/TTNNNN 11 -- int10--------
    rs345403591,2
    C--67400255(+) TTTTTT/-GTGGA 11 -- int12Minor allele frequency- -:0.25NA 4
    rs571096591,2
    C--67403276(+) GAAAA-/GAAAA 
            
    TGTGT
    11 -- int10--------
    rs1138299731,2
    F--67407546(+) TACTCG/AGAAGG 11 -- int11Minor allele frequency- A:0.50CSA 2
    rs106271971,2
    C--67407653(+) aaaaa-/A/AA  
            
    aaaaa
    11 -- int1 trp32NA 4
    rs2000071321,2
    C--67410951(+) GTGTG-/TATATATATATATA
    TATATATATATATATA
    TATAT
    11 -- int10--------
    rs665255701,2
    C--67410991(-) TATTT-/TATA  
      TATATA
    TATAT
    11 -- int11Minor allele frequency- TATATATATA:0.00NA 2

    HapMap Linkage Disequilibrium report for MIER1 (67390578 - 67454302 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for MIER1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv273286CNV Insertion20981092
    nsv871720CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MIER1
    DNA2.0 Custom Variant and Variant Library Synthesis for MIER1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MIER1 gene, integrated from 10 sources (see all 34):
    (articles sorted by number of sources associating them with MIER1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genomic organization of the human mi-er1 gene and characterization of alternatively spliced isoforms: regulated use of a facultative intron determines subcellular localization. (PubMed id 12242014)1, 2, 3, 9 Paterno G.D....Gillespie L.L. (Gene 2002)
    2. Human MI-ER1 alpha and beta function as transcriptional repressors by recruitment of histone deacetylase 1 to their conserved ELM2 domain. (PubMed id 12482978)1, 2, 3 Ding Z.... Paterno G.D. (Mol. Cell. Biol. 2003)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10997877)1, 2 Nagase T.... Ohara O. (DNA Res. 2000)
    8. Molecular cloning of human er1 cDNA and its differential expression in breast tumours and tumour-derived cell lines. (PubMed id 9813250)1, 2 Paterno G.D....Gillespie L.L. (Gene 1998)
    9. The SANT domain of human MI-ER1 interacts with Sp1 to interfere with GC box recognition and repress transcription from its own promoter. (PubMed id 15117948)1, 9 Ding Z....Paterno G.D. (J. Biol. Chem. 2004)
    10. The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (PubMed id 23667531)1 Cox J.L....Rizzino A. (PLoS ONE 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 57708 HGNC: 29657 AceView: MI-ER1 Ensembl:ENSG00000198160 euGenes: HUgn57708
    ECgene: MIER1 H-InvDB: MIER1

    (According to HUGE)
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    HUGE: KIAA1610

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for MIER1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MIER1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MIER1 gene:
    Search GeneIP for patents involving MIER1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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