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Aliases for MIER1 Gene

Aliases for MIER1 Gene

  • MIER1 Transcriptional Regulator 2 3 5
  • Mesoderm Induction Early Response 1, Transcriptional Regulator 2 3
  • MI-ER1 3 4
  • ER1 3 4
  • Mesoderm Induction Early Response 1 Homolog (Xenopus Laevis) 2
  • Mesoderm Induction Early Response 1 Homolog 3
  • Mesoderm Induction Early Response Protein 1 3
  • Early Response 1 4
  • KIAA1610 4
  • HMi-Er1 4

External Ids for MIER1 Gene

Previous GeneCards Identifiers for MIER1 Gene

  • GC01P067103
  • GC01P067390
  • GC01P065499

Summaries for MIER1 Gene

Entrez Gene Summary for MIER1 Gene

  • This gene encodes a protein that was first identified in Xenopus laevis by its role in a mesoderm induction early response (MIER). The encoded protein functions as a transcriptional regulator. Alternatively spliced transcript variants encode multiple isoforms, some of which lack a C-terminal nuclear localization signal. [provided by RefSeq, May 2013]

GeneCards Summary for MIER1 Gene

MIER1 (MIER1 Transcriptional Regulator) is a Protein Coding gene. GO annotations related to this gene include chromatin binding and signal transducer activity. An important paralog of this gene is MIER3.

UniProtKB/Swiss-Prot for MIER1 Gene

  • Transcriptional repressor regulating the expression of a number of genes including SP1 target genes. Probably functions through recruitment of HDAC1 a histone deacetylase involved in chromatin silencing.

Gene Wiki entry for MIER1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIER1 Gene

Genomics for MIER1 Gene

Regulatory Elements for MIER1 Gene

Enhancers for MIER1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G066923 1.4 ENCODE dbSUPER 10.7 +0.6 611 4.3 HDGF ARNT WRNIP1 ARID4B SIN3A DMAP1 FEZF1 YY1 ZNF143 ZNF207 WDR78 TCTEX1D1 MIER1 SLC35D1
GH01G066929 1.4 ENCODE dbSUPER 10.2 +7.6 7576 6.9 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A ZNF2 YY1 ZNF766 ZNF416 WDR78 TCTEX1D1 MIER1 SLC35D1
GH01G066980 1 Ensembl ENCODE 9.9 +56.7 56689 2.0 SOX13 IRF2 FOXA2 RAD21 ZBTB40 YY1 ZNF366 KLF8 SOX5 HLF WDR78 MIER1 SLC35D1
GH01G067018 1 Ensembl ENCODE 9.9 +94.9 94916 2.2 PKNOX1 JUN ZIC2 HIC1 ZNF316 ZFHX2 EGR2 MTA2 ZBTB8A NR2F2 WDR78 C1orf141 ENSG00000252433 MIER1 SLC35D1
GH01G066937 0.6 Ensembl 10.2 +12.5 12506 0.4 ZNF121 MAFF ZNF316 ZNF362 ADNP ZBTB33 EMSY MIER1 WDR78 SLC35D1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIER1 on UCSC Golden Path with GeneCards custom track

Promoters for MIER1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000008146 305 2401 HDGF ARNT WRNIP1 ARID4B SIN3A DMAP1 FEZF1 YY1 ZNF143 ZNF207

Genomic Location for MIER1 Gene

Chromosome:
1
Start:
66,924,895 bp from pter
End:
66,988,619 bp from pter
Size:
63,725 bases
Orientation:
Plus strand

Genomic View for MIER1 Gene

Genes around MIER1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIER1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIER1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIER1 Gene

Proteins for MIER1 Gene

  • Protein details for MIER1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N108-MIER1_HUMAN
    Recommended name:
    Mesoderm induction early response protein 1
    Protein Accession:
    Q8N108
    Secondary Accessions:
    • C9JFD4
    • Q08AE0
    • Q32NC4
    • Q5T104
    • Q5TAD1
    • Q5TAD2
    • Q5TAD4
    • Q5TAD5
    • Q6AHY8
    • Q86TB4
    • Q8N156
    • Q8N161
    • Q8NC37
    • Q8NES4
    • Q8NES5
    • Q8NES6
    • Q8WWG2
    • Q9HCG2

    Protein attributes for MIER1 Gene

    Size:
    512 amino acids
    Molecular mass:
    57983 Da
    Quaternary structure:
    • Interacts with HDAC1. Part of a complex containing at least CDYL, MIER1, MIER2, HDAC1 and HDAC2.
    SequenceCaution:
    • Sequence=AAH17423.1; Type=Miscellaneous discrepancy; Note=Wrong choice of CDS. Probable cloning artifact due to reverse transcription from RNA internal poly-A tracts.; Evidence={ECO:0000305}; Sequence=AAM76041.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAM97500.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAM97503.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAM97506.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC11339.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA. C-terminal is identical to the product of the WLS gene.; Evidence={ECO:0000305}; Sequence=CAD89921.1; Type=Miscellaneous discrepancy; Note=Wrong choice of CDS.; Evidence={ECO:0000305};

    Alternative splice isoforms for MIER1 Gene

neXtProt entry for MIER1 Gene

Post-translational modifications for MIER1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MIER1 Gene

Domains & Families for MIER1 Gene

Gene Families for MIER1 Gene

Protein Domains for MIER1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIER1: view

No data available for UniProtKB/Swiss-Prot for MIER1 Gene

Function for MIER1 Gene

Molecular function for MIER1 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional repressor regulating the expression of a number of genes including SP1 target genes. Probably functions through recruitment of HDAC1 a histone deacetylase involved in chromatin silencing.

Gene Ontology (GO) - Molecular Function for MIER1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0004871 signal transducer activity IMP 12761501
GO:0005515 protein binding IPI 12482978
genes like me logo Genes that share ontologies with MIER1: view

Phenotypes for MIER1 Gene

genes like me logo Genes that share phenotypes with MIER1: view

Animal Models for MIER1 Gene

MGI Knock Outs for MIER1:

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MIER1 Gene

Localization for MIER1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIER1 Gene

Isoform 1: Nucleus.
Isoform 2: Nucleus.
Isoform 3: Nucleus.
Isoform 4: Cytoplasm.
Isoform 5: Cytoplasm.
Isoform 6: Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIER1 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for MIER1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0017053 transcriptional repressor complex IDA 12482978
genes like me logo Genes that share ontologies with MIER1: view

Pathways & Interactions for MIER1 Gene

SuperPathways for MIER1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIER1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007165 signal transduction IEA --
GO:0031937 positive regulation of chromatin silencing IDA 12482978
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IMP 12761501
genes like me logo Genes that share ontologies with MIER1: view

No data available for Pathways by source and SIGNOR curated interactions for MIER1 Gene

Drugs & Compounds for MIER1 Gene

No Compound Related Data Available

Transcripts for MIER1 Gene

Unigene Clusters for MIER1 Gene

Mesoderm induction early response 1 homolog (Xenopus laevis):
Representative Sequences:

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIER1 Gene

No ASD Table

Relevant External Links for MIER1 Gene

GeneLoc Exon Structure for
MIER1
ECgene alternative splicing isoforms for
MIER1

Expression for MIER1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIER1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MIER1 Gene

This gene is overexpressed in Plasma (21.1), Peripheral blood mononuclear cells (15.0), and Blymphocyte (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MIER1 Gene



Protein tissue co-expression partners for MIER1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MIER1 Gene:

MIER1

SOURCE GeneReport for Unigene cluster for MIER1 Gene:

Hs.605432

mRNA Expression by UniProt/SwissProt for MIER1 Gene:

Q8N108-MIER1_HUMAN
Tissue specificity: Ubiquitously expressed, but at very low levels. However, consistent level of expression are observed in heart, testis, thyroid, ovary and adrenal gland. Transcripts are up-regulated in breast carcinoma cell lines and tumor.

Evidence on tissue expression from TISSUES for MIER1 Gene

  • Liver(4.4)
  • Lung(4.4)
  • Muscle(4.3)
  • Eye(4.1)
genes like me logo Genes that share expression patterns with MIER1: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIER1 Gene

Orthologs for MIER1 Gene

This gene was present in the common ancestor of animals.

Orthologs for MIER1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MIER1 35
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MIER1 35
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MIER1 35
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mier1 34
  • 91.7 (n)
mouse
(Mus musculus)
Mammalia Mier1 34 16 35
  • 90.59 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MIER1 35
  • 70 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MIER1 35
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves MIER1 35
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MIER1 35
  • 83 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia mi-er1-prov 34
zebrafish
(Danio rerio)
Actinopterygii mier1a 34
  • 62.95 (n)
mier1b 35
  • 59 (a)
OneToOne
wufb30a02 34
fruit fly
(Drosophila melanogaster)
Insecta CG1620 35
  • 21 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F10E7.11 35
  • 26 (a)
ManyToMany
T07F8.4 35
  • 26 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 33 (a)
OneToOne
Species where no ortholog for MIER1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MIER1 Gene

ENSEMBL:
Gene Tree for MIER1 (if available)
TreeFam:
Gene Tree for MIER1 (if available)

Paralogs for MIER1 Gene

Paralogs for MIER1 Gene

(2) SIMAP similar genes for MIER1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with MIER1: view

Variants for MIER1 Gene

Sequence variations from dbSNP and Humsavar for MIER1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000075971 -- 66,978,183(+) AGAGC(A/G)AAACT intron-variant
rs1000109274 -- 66,930,846(+) GTGGG(A/G)AAAAC intron-variant
rs1000135598 -- 66,986,348(+) TAGAC(C/T)AACCT intron-variant, nc-transcript-variant, utr-variant-3-prime
rs1000168630 -- 66,953,947(+) TTTTT(C/T)CCATG intron-variant
rs1000274356 -- 66,962,823(+) ATCAG(A/C)ATTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MIER1 Gene

Variant ID Type Subtype PubMed ID
esv3309013 CNV mobile element insertion 20981092
esv3398423 CNV insertion 20981092
nsv1078294 OTHER inversion 25765185

Variation tolerance for MIER1 Gene

Residual Variation Intolerance Score: 38.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.24; 52.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MIER1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIER1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MIER1 Gene

Disorders for MIER1 Gene

Relevant External Links for MIER1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIER1

No disorders were found for MIER1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIER1 Gene

Publications for MIER1 Gene

  1. Genomic organization of the human mi-er1 gene and characterization of alternatively spliced isoforms: regulated use of a facultative intron determines subcellular localization. (PMID: 12242014) Paterno G.D. … Gillespie L.L. (Gene 2002) 2 3 4 22 64
  2. Human MI-ER1 alpha and beta function as transcriptional repressors by recruitment of histone deacetylase 1 to their conserved ELM2 domain. (PMID: 12482978) Ding Z. … Paterno G.D. (Mol. Cell. Biol. 2003) 2 3 4 64
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for MIER1 Gene

Sources for MIER1 Gene

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