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Aliases for MIER1 Gene

Aliases for MIER1 Gene

  • Mesoderm Induction Early Response 1, Transcriptional Regulator 2 3
  • MI-ER1 3 4
  • ER1 3 4
  • Mesoderm Induction Early Response 1 Homolog (Xenopus Laevis) 2
  • Mesoderm Induction Early Response 1 Homolog 3
  • Mesoderm Induction Early Response Protein 1 3
  • Early Response 1 4
  • KIAA1610 4
  • HMi-Er1 4

External Ids for MIER1 Gene

Summaries for MIER1 Gene

Entrez Gene Summary for MIER1 Gene

  • This gene encodes a protein that was first identified in Xenopus laevis by its role in a mesoderm induction early response (MIER). The encoded protein functions as a transcriptional regulator. Alternatively spliced transcript variants encode multiple isoforms, some of which lack a C-terminal nuclear localization signal. [provided by RefSeq, May 2013]

GeneCards Summary for MIER1 Gene

MIER1 (Mesoderm Induction Early Response 1, Transcriptional Regulator) is a Protein Coding gene. GO annotations related to this gene include chromatin binding and signal transducer activity. An important paralog of this gene is MIER2.

UniProtKB/Swiss-Prot for MIER1 Gene

  • Transcriptional repressor regulating the expression of a number of genes including SP1 target genes. Probably functions through recruitment of HDAC1 a histone deacetylase involved in chromatin silencing.

Gene Wiki entry for MIER1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIER1 Gene

Genomics for MIER1 Gene

Genomic Location for MIER1 Gene

Start:
66,924,895 bp from pter
End:
66,988,619 bp from pter
Size:
63,725 bases
Orientation:
Plus strand

Genomic View for MIER1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIER1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIER1 Gene

Regulatory Elements for MIER1 Gene

Proteins for MIER1 Gene

  • Protein details for MIER1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N108-MIER1_HUMAN
    Recommended name:
    Mesoderm induction early response protein 1
    Protein Accession:
    Q8N108
    Secondary Accessions:
    • C9JFD4
    • Q08AE0
    • Q32NC4
    • Q5T104
    • Q5TAD1
    • Q5TAD2
    • Q5TAD4
    • Q5TAD5
    • Q6AHY8
    • Q86TB4
    • Q8N156
    • Q8N161
    • Q8NC37
    • Q8NES4
    • Q8NES5
    • Q8NES6
    • Q8WWG2
    • Q9HCG2

    Protein attributes for MIER1 Gene

    Size:
    512 amino acids
    Molecular mass:
    57983 Da
    Quaternary structure:
    • Interacts with HDAC1. Part of a complex containing at least CDYL, MIER1, MIER2, HDAC1 and HDAC2.
    SequenceCaution:
    • Sequence=AAH17423.1; Type=Miscellaneous discrepancy; Note=Wrong choice of CDS. Probable cloning artifact due to reverse transcription from RNA internal poly-A tracts.; Evidence={ECO:0000305}; Sequence=AAM76041.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAM97500.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAM97503.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAM97506.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC11339.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA. C-terminal is identical to the product of the WLS gene.; Evidence={ECO:0000305}; Sequence=CAD89921.1; Type=Miscellaneous discrepancy; Note=Wrong choice of CDS.; Evidence={ECO:0000305};

    Alternative splice isoforms for MIER1 Gene

neXtProt entry for MIER1 Gene

Proteomics data for MIER1 Gene at MOPED

Post-translational modifications for MIER1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MIER1 Gene

Domains for MIER1 Gene

Protein Domains for MIER1 Gene

UniProtKB/Swiss-Prot:

MIER1_HUMAN
Domain:
  • Contains 1 ELM2 domain.:
    • Q8N108
  • Contains 1 SANT domain.:
    • Q8N108
genes like me logo Genes that share domains with MIER1: view

No data available for Gene Families for MIER1 Gene

Function for MIER1 Gene

Molecular function for MIER1 Gene

UniProtKB/Swiss-Prot Function: Transcriptional repressor regulating the expression of a number of genes including SP1 target genes. Probably functions through recruitment of HDAC1 a histone deacetylase involved in chromatin silencing.

Gene Ontology (GO) - Molecular Function for MIER1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003682 chromatin binding IEA --
GO:0004871 signal transducer activity IMP 12761501
GO:0005515 protein binding IPI 12482978
genes like me logo Genes that share ontologies with MIER1: view
genes like me logo Genes that share phenotypes with MIER1: view

miRNA for MIER1 Gene

miRTarBase miRNAs that target MIER1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for MIER1 Gene

Localization for MIER1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIER1 Gene

Isoform 1: Nucleus.
Isoform 2: Nucleus.
Isoform 3: Nucleus.
Isoform 4: Cytoplasm.
Isoform 5: Cytoplasm.
Isoform 6: Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MIER1 Gene COMPARTMENTS Subcellular localization image for MIER1 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for MIER1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0017053 transcriptional repressor complex IDA 12482978
genes like me logo Genes that share ontologies with MIER1: view

Pathways for MIER1 Gene

SuperPathways for MIER1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIER1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0007165 signal transduction IMP 12761501
GO:0031937 positive regulation of chromatin silencing IDA 12482978
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IMP 12761501
genes like me logo Genes that share ontologies with MIER1: view

No data available for Pathways by source for MIER1 Gene

Transcripts for MIER1 Gene

Unigene Clusters for MIER1 Gene

Mesoderm induction early response 1 homolog (Xenopus laevis):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MIER1 Gene

No ASD Table

Relevant External Links for MIER1 Gene

GeneLoc Exon Structure for
MIER1
ECgene alternative splicing isoforms for
MIER1

Expression for MIER1 Gene

mRNA expression in normal human tissues for MIER1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MIER1 Gene

SOURCE GeneReport for Unigene cluster for MIER1 Gene Hs.605432

mRNA Expression by UniProt/SwissProt for MIER1 Gene

Q8N108-MIER1_HUMAN
Tissue specificity: Ubiquitously expressed, but at very low levels. However, consistent level of expression are observed in heart, testis, thyroid, ovary and adrenal gland. Transcripts are up-regulated in breast carcinoma cell lines and tumor.
genes like me logo Genes that share expressions with MIER1: view

Orthologs for MIER1 Gene

This gene was present in the common ancestor of animals.

Orthologs for MIER1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MIER1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MIER1 37
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MIER1 37
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mier1 36
  • 90.59 (n)
  • 93.37 (a)
Mier1 16
Mier1 37
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MIER1 37
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MIER1 37
  • 70 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mier1 36
  • 91.7 (n)
  • 94.51 (a)
chicken
(Gallus gallus)
Aves MIER1 37
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MIER1 37
  • 83 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia mi-er1-prov 36
zebrafish
(Danio rerio)
Actinopterygii mier1a 36
  • 62.95 (n)
  • 57.68 (a)
mier1b 37
  • 59 (a)
OneToOne
wufb30a02 36
fruit fly
(Drosophila melanogaster)
Insecta CG1620 37
  • 21 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F10E7.11 37
  • 26 (a)
ManyToMany
T07F8.4 37
  • 26 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 33 (a)
OneToOne
Species with no ortholog for MIER1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MIER1 Gene

ENSEMBL:
Gene Tree for MIER1 (if available)
TreeFam:
Gene Tree for MIER1 (if available)

Paralogs for MIER1 Gene

Paralogs for MIER1 Gene

Selected SIMAP similar genes for MIER1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with MIER1: view

Variants for MIER1 Gene

Sequence variations from dbSNP and Humsavar for MIER1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs730590 -- 66,946,107(-) TTAAG(G/T)GGATC intron-variant
rs912797 -- 66,947,795(+) taccc(A/G)tgtat intron-variant, utr-variant-3-prime
rs1137656 -- 66,985,919(-) AATTA(G/T)AGCAA utr-variant-3-prime, intron-variant
rs1570838 -- 66,937,632(+) GTAAG(C/T)TGGAT intron-variant
rs1925412 -- 66,939,374(+) ATGGT(A/G)GAGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MIER1 Gene

Variant ID Type Subtype PubMed ID
nsv871720 CNV Loss 21882294
esv273286 CNV Insertion 20981092

Relevant External Links for MIER1 Gene

HapMap Linkage Disequilibrium report
MIER1

Disorders for MIER1 Gene

No disorders were found for MIER1 Gene.

No data available for UniProtKB/Swiss-Prot for MIER1 Gene

Publications for MIER1 Gene

  1. Genomic organization of the human mi-er1 gene and characterization of alternatively spliced isoforms: regulated use of a facultative intron determines subcellular localization. (PMID: 12242014) Paterno G.D. … Gillespie L.L. (Gene 2002) 2 3 4 23
  2. Human MI-ER1 alpha and beta function as transcriptional repressors by recruitment of histone deacetylase 1 to their conserved ELM2 domain. (PMID: 12482978) Ding Z. … Paterno G.D. (Mol. Cell. Biol. 2003) 2 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The SANT domain of human MI-ER1 interacts with Sp1 to interfere with GC box recognition and repress transcription from its own promoter. (PMID: 15117948) Ding Z. … Paterno G.D. (J. Biol. Chem. 2004) 3 23
  5. Molecular cloning of human er1 cDNA and its differential expression in breast tumours and tumour-derived cell lines. (PMID: 9813250) Paterno G.D. … Gillespie L.L. (Gene 1998) 3 4

Products for MIER1 Gene

Sources for MIER1 Gene

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