Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MIER1 Gene

Aliases for MIER1 Gene

  • Mesoderm Induction Early Response 1, Transcriptional Regulator 2 3
  • MI-ER1 3 4
  • ER1 3 4
  • Mesoderm Induction Early Response 1 Homolog (Xenopus Laevis) 2
  • Mesoderm Induction Early Response 1 Homolog 3
  • Early Response 1 4
  • KIAA1610 4
  • HMi-Er1 4

External Ids for MIER1 Gene

Previous GeneCards Identifiers for MIER1 Gene

  • GC01P067103
  • GC01P067390
  • GC01P065499

Summaries for MIER1 Gene

Entrez Gene Summary for MIER1 Gene

  • This gene encodes a protein that was first identified in Xenopus laevis by its role in a mesoderm induction early response (MIER). The encoded protein functions as a transcriptional regulator. Alternatively spliced transcript variants encode multiple isoforms, some of which lack a C-terminal nuclear localization signal. [provided by RefSeq, May 2013]

GeneCards Summary for MIER1 Gene

MIER1 (Mesoderm Induction Early Response 1, Transcriptional Regulator) is a Protein Coding gene. GO annotations related to this gene include chromatin binding and signal transducer activity. An important paralog of this gene is MIER2.

UniProtKB/Swiss-Prot for MIER1 Gene

  • Transcriptional repressor regulating the expression of a number of genes including SP1 target genes. Probably functions through recruitment of HDAC1 a histone deacetylase involved in chromatin silencing.

Gene Wiki entry for MIER1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIER1 Gene

Genomics for MIER1 Gene

Regulatory Elements for MIER1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MIER1 Gene

Chromosome:
1
Start:
66,924,895 bp from pter
End:
66,988,619 bp from pter
Size:
63,725 bases
Orientation:
Plus strand

Genomic View for MIER1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIER1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIER1 Gene

Proteins for MIER1 Gene

  • Protein details for MIER1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N108-MIER1_HUMAN
    Recommended name:
    Mesoderm induction early response protein 1
    Protein Accession:
    Q8N108
    Secondary Accessions:
    • C9JFD4
    • Q08AE0
    • Q32NC4
    • Q5T104
    • Q5TAD1
    • Q5TAD2
    • Q5TAD4
    • Q5TAD5
    • Q6AHY8
    • Q86TB4
    • Q8N156
    • Q8N161
    • Q8NC37
    • Q8NES4
    • Q8NES5
    • Q8NES6
    • Q8WWG2
    • Q9HCG2

    Protein attributes for MIER1 Gene

    Size:
    512 amino acids
    Molecular mass:
    57983 Da
    Quaternary structure:
    • Interacts with HDAC1. Part of a complex containing at least CDYL, MIER1, MIER2, HDAC1 and HDAC2.
    SequenceCaution:
    • Sequence=AAH17423.1; Type=Miscellaneous discrepancy; Note=Wrong choice of CDS. Probable cloning artifact due to reverse transcription from RNA internal poly-A tracts.; Evidence={ECO:0000305}; Sequence=AAM76041.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAM97500.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAM97503.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAM97506.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC11339.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA. C-terminal is identical to the product of the WLS gene.; Evidence={ECO:0000305}; Sequence=CAD89921.1; Type=Miscellaneous discrepancy; Note=Wrong choice of CDS.; Evidence={ECO:0000305};

    Alternative splice isoforms for MIER1 Gene

neXtProt entry for MIER1 Gene

Proteomics data for MIER1 Gene at MOPED

Post-translational modifications for MIER1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MIER1 Gene

Domains & Families for MIER1 Gene

Gene Families for MIER1 Gene

Protein Domains for MIER1 Gene

Graphical View of Domain Structure for InterPro Entry

Q8N108

UniProtKB/Swiss-Prot:

MIER1_HUMAN :
  • Contains 1 ELM2 domain.
Domain:
  • Contains 1 ELM2 domain.
  • Contains 1 SANT domain.
genes like me logo Genes that share domains with MIER1: view

Function for MIER1 Gene

Molecular function for MIER1 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional repressor regulating the expression of a number of genes including SP1 target genes. Probably functions through recruitment of HDAC1 a histone deacetylase involved in chromatin silencing.

Gene Ontology (GO) - Molecular Function for MIER1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0004871 signal transducer activity IMP 12761501
GO:0005515 protein binding IPI 12482978
genes like me logo Genes that share ontologies with MIER1: view
genes like me logo Genes that share phenotypes with MIER1: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MIER1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for MIER1 Gene

Localization for MIER1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIER1 Gene

Isoform 1: Nucleus.
Isoform 2: Nucleus.
Isoform 3: Nucleus.
Isoform 4: Cytoplasm.
Isoform 5: Cytoplasm.
Isoform 6: Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MIER1 Gene COMPARTMENTS Subcellular localization image for MIER1 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for MIER1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0017053 transcriptional repressor complex IDA 12482978
genes like me logo Genes that share ontologies with MIER1: view

Pathways & Interactions for MIER1 Gene

SuperPathways for MIER1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIER1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0007165 signal transduction IEA --
GO:0031937 positive regulation of chromatin silencing IDA 12482978
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IMP 12761501
genes like me logo Genes that share ontologies with MIER1: view

No data available for Pathways by source and SIGNOR curated interactions for MIER1 Gene

Drugs & Compounds for MIER1 Gene

No Compound Related Data Available

Transcripts for MIER1 Gene

Unigene Clusters for MIER1 Gene

Mesoderm induction early response 1 homolog (Xenopus laevis):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MIER1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIER1 Gene

No ASD Table

Relevant External Links for MIER1 Gene

GeneLoc Exon Structure for
MIER1
ECgene alternative splicing isoforms for
MIER1

Expression for MIER1 Gene

mRNA expression in normal human tissues for MIER1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MIER1 Gene

This gene is overexpressed in Plasma (21.1), Peripheral blood mononuclear cells (15.0), and Blymphocyte (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MIER1 Gene



SOURCE GeneReport for Unigene cluster for MIER1 Gene Hs.605432

mRNA Expression by UniProt/SwissProt for MIER1 Gene

Q8N108-MIER1_HUMAN
Tissue specificity: Ubiquitously expressed, but at very low levels. However, consistent level of expression are observed in heart, testis, thyroid, ovary and adrenal gland. Transcripts are up-regulated in breast carcinoma cell lines and tumor.
genes like me logo Genes that share expression patterns with MIER1: view

Protein tissue co-expression partners for MIER1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for MIER1 Gene

Orthologs for MIER1 Gene

This gene was present in the common ancestor of animals.

Orthologs for MIER1 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Mier1 35
  • 90.59 (n)
  • 93.37 (a)
Mier1 16
Mier1 36
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mier1 35
  • 91.7 (n)
  • 94.51 (a)
cow
(Bos Taurus)
Mammalia MIER1 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MIER1 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MIER1 36
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MIER1 36
  • 70 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MIER1 36
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves MIER1 36
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MIER1 36
  • 83 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia mi-er1-prov 35
zebrafish
(Danio rerio)
Actinopterygii mier1a 35
  • 62.95 (n)
  • 57.68 (a)
wufb30a02 35
mier1b 36
  • 59 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG1620 36
  • 21 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F10E7.11 36
  • 26 (a)
ManyToMany
T07F8.4 36
  • 26 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 33 (a)
OneToOne
Species with no ortholog for MIER1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MIER1 Gene

ENSEMBL:
Gene Tree for MIER1 (if available)
TreeFam:
Gene Tree for MIER1 (if available)

Paralogs for MIER1 Gene

Paralogs for MIER1 Gene

(2) SIMAP similar genes for MIER1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with MIER1: view

Variants for MIER1 Gene

Sequence variations from dbSNP and Humsavar for MIER1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs912797 -- 66,947,795(+) taccc(A/G)tgtat intron-variant, utr-variant-3-prime
rs34540359 -- 66,934,572(+) TTTTT(-/T/TT)GTGGA intron-variant
rs34619018 -- 66,937,537(+) CCAAG(A/C)TCATG intron-variant
rs34760910 -- 66,964,673(+) TCTTG(-/G)AACTC intron-variant
rs34813338 -- 66,948,685(+) GCCTG(C/G)AGGTC intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for MIER1 Gene

Variant ID Type Subtype PubMed ID
nsv871720 CNV Loss 21882294
esv273286 CNV Insertion 20981092

Variation tolerance for MIER1 Gene

Residual Variation Intolerance Score: 38.64% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.24; 52.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MIER1 Gene

HapMap Linkage Disequilibrium report
MIER1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MIER1 Gene

Disorders for MIER1 Gene

Relevant External Links for MIER1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIER1
genes like me logo Genes that share disorders with MIER1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIER1 Gene

Publications for MIER1 Gene

  1. Genomic organization of the human mi-er1 gene and characterization of alternatively spliced isoforms: regulated use of a facultative intron determines subcellular localization. (PMID: 12242014) Paterno G.D. … Gillespie L.L. (Gene 2002) 2 23 67
  2. The SANT domain of human MI-ER1 interacts with Sp1 to interfere with GC box recognition and repress transcription from its own promoter. (PMID: 15117948) Ding Z. … Paterno G.D. (J. Biol. Chem. 2004) 23 67
  3. Human MI-ER1 alpha and beta function as transcriptional repressors by recruitment of histone deacetylase 1 to their conserved ELM2 domain. (PMID: 12482978) Ding Z. … Paterno G.D. (Mol. Cell. Biol. 2003) 2 67
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  5. Uncovering global SUMOylation signaling networks in a site-specific manner. (PMID: 25218447) Hendriks I.A. … Vertegaal A.C. (Nat. Struct. Mol. Biol. 2014) 67

Products for MIER1 Gene

Sources for MIER1 Gene

Back to Top

Content