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Aliases for MIEN1 Gene

Subcategory (RNA class) for MIEN1 Gene

antisense

Aliases for MIEN1 Gene

  • Migration And Invasion Enhancer 1 2 3
  • C17orf37 3 4 6
  • RDX12 3 4 6
  • HBV X-Transactivated Gene 4 Protein 3 4
  • HBV XAg-Transactivated Protein 4 3 4
  • XTP4 3 4
  • Chromosome 17 Open Reading Frame 37 2
  • Protein C17orf37 3
  • Protein C35 4
  • ORB3 3
  • C35 3

External Ids for MIEN1 Gene

ORGUL Members for MIEN1 Gene

Previous Symbols for MIEN1 Gene

  • C17orf37

Summaries for MIEN1 Gene

GeneCards Summary for MIEN1 Gene

MIEN1 (Migration And Invasion Enhancer 1) is a Protein Coding gene, and belongs to antisense RNA class. Diseases associated with MIEN1 include brain cancer and prostate adenocarcinoma. GO annotations related to this gene include selenium binding.

UniProtKB/Swiss-Prot for MIEN1 Gene

  • Increases cell migration by inducing filopodia formation at the leading edge of migrating cells. Plays a role in regulation of apoptosis, possibly through control of CASP3. May be involved in a redox-related process.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIEN1 Gene

Genomics for MIEN1 Gene

Genomic Location for MIEN1 Gene

Start:
39,728,496 bp from pter
End:
39,730,787 bp from pter
Size:
2,292 bases
Orientation:
Minus strand

Genomic View for MIEN1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIEN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIEN1 Gene

No data available for Regulatory Elements for MIEN1 Gene

Proteins for MIEN1 Gene

  • Protein details for MIEN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BRT3-MIEN1_HUMAN
    Recommended name:
    Migration and invasion enhancer 1
    Protein Accession:
    Q9BRT3
    Secondary Accessions:

    Protein attributes for MIEN1 Gene

    Size:
    115 amino acids
    Molecular mass:
    12403 Da
    Quaternary structure:
    • Interacts with GPX1.

    Three dimensional structures from OCA and Proteopedia for MIEN1 Gene

neXtProt entry for MIEN1 Gene

Proteomics data for MIEN1 Gene at MOPED

Post-translational modifications for MIEN1 Gene

  • Isoprenylation facilitates association with the plasma membrane and enhances the migratory phenotype of cells by inducing increased filopodia formation.

Other Protein References for MIEN1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MIEN1 Gene

Domains for MIEN1 Gene

Protein Domains for MIEN1 Gene

UniProtKB/Swiss-Prot:

MIEN1_HUMAN
Family:
  • Belongs to the SelWTH family.:
    • Q9BRT3
genes like me logo Genes that share domains with MIEN1: view

No data available for Gene Families for MIEN1 Gene

Function for MIEN1 Gene

Molecular function for MIEN1 Gene

UniProtKB/Swiss-Prot Function: Increases cell migration by inducing filopodia formation at the leading edge of migrating cells. Plays a role in regulation of apoptosis, possibly through control of CASP3. May be involved in a redox-related process.

Gene Ontology (GO) - Molecular Function for MIEN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0008430 selenium binding IEA --
genes like me logo Genes that share ontologies with MIEN1: view

Phenotypes for MIEN1 Gene

GenomeRNAi human phenotypes for MIEN1:
genes like me logo Genes that share phenotypes with MIEN1: view

miRNA for MIEN1 Gene

miRTarBase miRNAs that target MIEN1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for MIEN1 Gene

Localization for MIEN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIEN1 Gene

Cytoplasm, cytosol. Cell membrane; Lipid-anchor; Cytoplasmic side. Note=Concentrates at the leading edge of migrating cells. Localizes outside membrane raft regions.

Gene Ontology (GO) - Cellular Components for MIEN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol IDA 21628459
GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane IDA 21628459
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with MIEN1: view

Pathways for MIEN1 Gene

SuperPathways for MIEN1 Gene

No Data Available

Interacting Proteins for MIEN1 Gene

Selected Interacting proteins: Q9BRT3-MIEN1_HUMAN for MIEN1 Gene via UniProtKB

Symbol External ID(s) Details
REL

Gene Ontology (GO) - Biological Process for MIEN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0030335 positive regulation of cell migration IDA 21628459
GO:0043066 negative regulation of apoptotic process IDA 21068479
GO:0045454 cell redox homeostasis IEA --
GO:0051491 positive regulation of filopodium assembly IDA 21628459
genes like me logo Genes that share ontologies with MIEN1: view

No data available for Pathways by source for MIEN1 Gene

Transcripts for MIEN1 Gene

Unigene Clusters for MIEN1 Gene

Migration and invasion enhancer 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MIEN1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b
SP1: -
SP2: -
SP3: -
SP4:
SP5:

Relevant External Links for MIEN1 Gene

GeneLoc Exon Structure for
MIEN1
ECgene alternative splicing isoforms for
MIEN1

Expression for MIEN1 Gene

mRNA expression in normal human tissues for MIEN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for MIEN1 Gene

SOURCE GeneReport for Unigene cluster for MIEN1 Gene Hs.333526

mRNA Expression by UniProt/SwissProt for MIEN1 Gene

Q9BRT3-MIEN1_HUMAN
Tissue specificity: Among normal tissues, present only in Leydig cells. Strongly up-regulated in breast cancers and in brain cancer distant metastasis (at protein level). Up-regulated in prostate cancer cells and in the higher grades of prostate adenocarcinoma (at protein level).
genes like me logo Genes that share expressions with MIEN1: view

Orthologs for MIEN1 Gene

This gene was present in the common ancestor of animals.

Orthologs for MIEN1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MIEN1 36
  • 98.84 (n)
  • 99.13 (a)
MIEN1 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MIEN1 36
  • 91.3 (n)
  • 93.91 (a)
MIEN1 37
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C17ORF37 37
  • 96 (a)
OneToOne
MIEN1 36
  • 92.75 (n)
  • 95.65 (a)
mouse
(Mus musculus)
Mammalia Mien1 36
  • 88.7 (n)
  • 89.57 (a)
Mien1 16
Mien1 37
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MIEN1 37
  • 51 (a)
OneToOne
chicken
(Gallus gallus)
Aves MIEN1 36
  • 71.49 (n)
  • 69.88 (a)
MIEN1 37
  • 54 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MIEN1 37
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mien1 36
  • 75.99 (n)
  • 78.49 (a)
Str.15598 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8692 36
zebrafish
(Danio rerio)
Actinopterygii sepw2a 36
  • 62.77 (n)
  • 53.19 (a)
sepw2a 37
  • 53 (a)
OneToMany
sepw2b 37
  • 47 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG15456 37
  • 35 (a)
OneToOne
Species with no ortholog for MIEN1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIEN1 Gene

ENSEMBL:
Gene Tree for MIEN1 (if available)
TreeFam:
Gene Tree for MIEN1 (if available)

Paralogs for MIEN1 Gene

Selected SIMAP similar genes for MIEN1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MIEN1: view

No data available for Paralogs for MIEN1 Gene

Variants for MIEN1 Gene

Sequence variations from dbSNP and Humsavar for MIEN1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs3809717 -- 39,730,733(-) GTGGG(G/T)AAGCC upstream-variant-2KB
rs4252666 -- 39,729,274(+) GCTTT(C/T)GTGGG utr-variant-3-prime
rs4252667 -- 39,729,388(+) AAGGG(-/G)CAAAG utr-variant-3-prime
rs8066205 -- 39,731,048(+) agctt(A/C)ccgag upstream-variant-2KB
rs8066496 -- 39,731,210(+) atgag(A/C)caccg upstream-variant-2KB

Relevant External Links for MIEN1 Gene

HapMap Linkage Disequilibrium report
MIEN1

No data available for Structural Variations from Database of Genomic Variants (DGV) for MIEN1 Gene

Disorders for MIEN1 Gene

(2) Novoseek inferred disease relationships for MIEN1 Gene

Disease -log(P) Hits PubMed IDs
breast cancer 21.3 3
tumors 0 4
genes like me logo Genes that share disorders with MIEN1: view

No data available for UniProtKB/Swiss-Prot for MIEN1 Gene

Publications for MIEN1 Gene

  1. C35 (C17orf37) is a novel tumor biomarker abundantly expressed in breast cancer. (PMID: 17121940) Evans E.E. … Zauderer M. (Mol. Cancer Ther. 2006) 2 3 4 23
  2. MGC9753 gene, located within PPP1R1B-STARD3-ERBB2-GRB7 amplicon on human chromosome 17q12, encodes the seven-transmembrane receptor with extracellular six-cysteine domain. (PMID: 12739007) Katoh M. … Katoh M. (Int. J. Oncol. 2003) 2 3 23
  3. Prenylated c17orf37 induces filopodia formation to promote cell migration and metastasis. (PMID: 21628459) Dasgupta S. … Vishwanatha J.K. (J. Biol. Chem. 2011) 2 3 4
  4. HapMap-based study of the 17q21 ERBB2 amplicon in susceptibility to breast cancer. (PMID: 17117180) Benusiglio P.R. … Ponder B.A. (Br. J. Cancer 2006) 3 23
  5. Novel gene C17orf37 in 17q12 amplicon promotes migration and invasion of prostate cancer cells. (PMID: 19503095) Dasgupta S. … Vishwanatha J.K. (Oncogene 2009) 3 4

Products for MIEN1 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate MIEN1
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for MIEN1
    • Block miRNA regulation of MIEN1 using miScript Target Protectors

    Sources for MIEN1 Gene

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