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MIEN1 Gene

protein-coding   GIFtS: 44
GCID: GC17M037886

Migration And Invasion Enhancer 1

(Previous name: chromosome 17 open reading frame 37)
(Previous symbol: C17orf37)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): antisense

Quality score for the ORGUL clustered with this gene is 3

Aliases
Migration And Invasion Enhancer 11 2     Chromosome 17 Open Reading Frame 371
C17orf371 2 3 5     C352
RDX122 3 5     ORB32
XTP42 3     Protein C17orf372
HBV X-Transactivated Gene 4 Protein2 3     Protein C353
HBV XAg-Transactivated Protein 42 3     

External Ids:    HGNC: 282301   Entrez Gene: 842992   Ensembl: ENSG000001417417   OMIM: 6118025   UniProtKB: Q9BRT33   
ORGUL members:         

Export aliases for MIEN1 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MIEN1 Gene:
MIEN1 (migration and invasion enhancer 1) is a protein-coding gene. Diseases associated with MIEN1 include brain cancer, and prostate adenocarcinoma. GO annotations related to this gene include selenium binding.

UniProtKB/Swiss-Prot: MIEN1_HUMAN, Q9BRT3
Function: Increases cell migration by inducing filopodia formation at the leading edge of migrating cells. Plays a
role in regulation of apoptosis, possibly through control of CASP3. May be involved in a redox-related process




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NT_010783.16  NC_018928.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for MIEN1
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMIEN1 promoter sequence
   Search Chromatin IP Primers for MIEN1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MIEN1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q12   Ensembl cytogenetic band:  17q12   HGNC cytogenetic band: 17q12

MIEN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MIEN1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M037886:  view genomic region     (about GC identifiers)

Start:
37,884,749 bp from pter      End:
37,887,040 bp from pter
Size:
2,292 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: MIEN1_HUMAN, Q9BRT3 (See protein sequence)
Recommended Name: Migration and invasion enhancer 1 precursor  
Size: 115 amino acids; 12403 Da
Subunit: Interacts with GPX1 (By similarity)
1 PDB 3D structure from and Proteopedia for MIEN1:
2LJK (3D)    

Explore the universe of human proteins at neXtProt for MIEN1: NX_Q9BRT3

Explore proteomics data for MIEN1 at MOPED

Post-translational modifications: 

  • Isoprenylation facilitates association with the plasma membrane and enhances the migratory phenotype of cells by
    inducing increased filopodia formation1
  • Modification sites at neXtProt

  • See MIEN1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_115715.3  
    ENSEMBL proteins: 
     ENSP00000377778   ENSP00000462998  

    MIEN1 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR012336 Thioredoxin-like_fold
     IPR011893 Selenoprotein_Rdx-typ

    Graphical View of Domain Structure for InterPro Entry Q9BRT3

    ProtoNet protein and cluster: Q9BRT3

    UniProtKB/Swiss-Prot: MIEN1_HUMAN, Q9BRT3
    Similarity: Belongs to the SelWTH family


    MIEN1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MIEN1_HUMAN, Q9BRT3
    Function: Increases cell migration by inducing filopodia formation at the leading edge of migrating cells. Plays a
    role in regulation of apoptosis, possibly through control of CASP3. May be involved in a redox-related process

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0008430selenium binding IEA--
         
    MIEN1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for MIEN1:
     Decreased nuclei size in G2M 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MIEN1
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MIEN1

    miRNA
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    miRTarBase miRNAs that target MIEN1:
    hsa-let-7b-5p (MIRT051901), hsa-mir-221-3p (MIRT046933)

    Block miRNA regulation of human, mouse, rat MIEN1 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate MIEN1
    SwitchGear 3'UTR luciferase reporter plasmidMIEN1 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MIEN1_HUMAN, Q9BRT3: Cytoplasm, cytosol. Cell membrane; Lipid-anchor; Cytoplasmic side. Note=Concentrates at the
    leading edge of migrating cells. Localizes outside membrane raft regions

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol IDA--
    GO:0031235intrinsic component of the cytoplasmic side of the plasma membrane IDA--

    MIEN1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MIEN1
    Interactions:

        Search GeneGlobe Interaction Network for MIEN1

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process IEA--
    GO:0030335positive regulation of cell migration IDA--
    GO:0043066negative regulation of apoptotic process IDA--
    GO:0045454cell redox homeostasis IEA--
    GO:0051491positive regulation of filopodium assembly IDA--

    MIEN1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MIEN1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MIEN1 gene: 
    NM_032339.3  

    Unigene Cluster for MIEN1:

    Migration and invasion enhancer 1
    Hs.333526  [show with all ESTs]
    Unigene Representative Sequence: BC063395
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000582963 ENST00000469568 ENST00000474210 ENST00000394231(uc002hsq.3)
    ENST00000577810 ENST00000498164
    miRNA
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    Primer
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    OriGene qPCR primer pairs and template standards for MIEN1
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      QuantiTect SYBR Green Assays in human, mouse, rat MIEN1
      QuantiFast Probe-based Assays in human, mouse, rat MIEN1

    Additional mRNA sequence: 

    AF490253.1 AJ308025.1 AJ308026.1 AY508814.1 BC006006.1 BC063395.1 BC106016.1 

    12 DOTS entries:

    DT.450536  DT.100027600  DT.215753  DT.120977063  DT.92459289  DT.40105898  DT.100786717  DT.120977168 
    DT.95188645  DT.100786715  DT.91716024  DT.95197022 

    Selected AceView cDNA sequences (see all 248):

    BQ423646 AI131184 AA308370 BM830780 BM715515 AI672936 W61294 BU170259 
    AI934846 CR613484 BI038873 R22331 AI051009 AA843586 AI336555 BU166943 
    NM_032339 BE616135 BE909438 AA759163 BQ130438 W44577 AA284919 BM842217 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for MIEN1    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b
    SP1:                          -                           
    SP2:                                -                     
    SP3:                          -                           
    SP4:                                                      
    SP5:                                                      


    ECgene alternative splicing isoforms for MIEN1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MIEN1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AACACTTCTC
    MIEN1 Expression
    About this image


    MIEN1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Epithelial Cells
             Presumptive Podocytes Podocyte Layer
     
     Kidney (Urinary System)
             Presumptive Podocytes Podocyte Layer
    MIEN1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MIEN1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.333526

    UniProtKB/Swiss-Prot: MIEN1_HUMAN, Q9BRT3
    Tissue specificity: Among normal tissues, present only in Leydig cells. Strongly up-regulated in breast cancers
    and in brain cancer distant metastasis (at protein level). Up-regulated in prostate cancer cells and in the
    higher grades of prostate adenocarcinoma (at protein level)

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MIEN1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MIEN1 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mien11 , 5 RIKEN cDNA 1810046J19 gene5
    migration and invasion enhancer 11
    88.7(n)1
    89.57(a)1
      11 (61.75 cM)5
    1037421  NM_025559.21  NP_079835.11 
     984377085 
    chicken
    (Gallus gallus)
    Aves MIEN11 migration and invasion enhancer 1 71.49(n)
    69.88(a)
      100858225  XM_003642806.2  XP_003642854.2 
    lizard
    (Anolis carolinensis)
    Reptilia MIEN16
    migration and invasion enhancer 1
    79(a)
    1 ↔ 1
    6(68408242-68415673)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.155982 Transcribed sequence with moderate similarity to protein more 81.12(n)    142016167 
    zebrafish
    (Danio rerio)
    Actinopterygii sepw2a2 selenoprotein W, 2a 76.91(n)   378437  AY221261.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG154566
    --
    35(a)
    1 ↔ 1
    X(20297536-20298104)


    ENSEMBL Gene Tree for MIEN1 (if available)
    TreeFam Gene Tree for MIEN1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MIEN1 gene
    1 SIMAP similar gene for MIEN1 using alignment to 2 protein entries:     MIEN1_HUMAN (see all proteins):
    SEPW1

    MIEN1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MIEN1 (see all 81)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs42526661,2
    C--37885527(+) GCTTTC/TGTGGG 1 -- ut31 ese33Minor allele frequency- T:0.01NS NA 184
    rs1429978271,2
    --37885528(+) CTTTCA/GTGGGC 1 -- ut310--------
    rs1506958081,2
    C--37885532(+) CGTGGA/GCACTT 1 -- ut310--------
    rs1399364171,2
    C--37885558(+) TATGAA/GGTGGC 1 -- ut310--------
    rs770528761,2
    C--37885638(+) TACCCA/GAAGGG 1 -- ut310--------
    rs345036751,2
    C--37885640(+) CCAAA-/GGGGCA 1 -- ut310--------
    rs748459951,2
    C--37885640(+) CCCAAG/AGGGCA 1 -- ut311Minor allele frequency- A:0.50CSA 2
    rs42526671,2
    C,F--37885641(+) CAAAG-/GGGCAA 1 -- ut312Minor allele frequency- G:0.10NS NA 180
    rs1855342691,2
    C--37885742(+) GACCCC/TAGAAC 1 -- ut310--------
    rs2018573341,2
    C--37885882(+) AGGATC/GATGCA 1 -- int10--------

    HapMap Linkage Disequilibrium report for MIEN1 (37884749 - 37887040 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for MIEN1: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MIEN1
    DNA2.0 Custom Variant and Variant Library Synthesis for MIEN1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611802    OMIM disorders: --

    6 diseases for MIEN1:    
    About MalaCards
    brain cancer    prostate adenocarcinoma    breast cancer    prostatitis
    adenocarcinoma    prostate cancer


    MIEN1 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for MIEN1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    breast cancer 21.3 4 17121940 (2), 17117180 (1)
    tumors 0 5 17121940 (4)


    Export disorders for MIEN1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MIEN1 gene, integrated from 10 sources (see all 22):
    (articles sorted by number of sources associating them with MIEN1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. C35 (C17orf37) is a novel tumor biomarker abundantly expressed in breast cancer. (PubMed id 17121940)1, 2, 3, 9 Evans E.E.... Zauderer M. (Mol. Cancer Ther. 2006)
    2. Prenylated c17orf37 induces filopodia formation to promote cell migration and metastasis. (PubMed id 21628459)1, 2, 3 Dasgupta S.... Vishwanatha J.K. (J. Biol. Chem. 2011)
    3. MGC9753 gene, located within PPP1R1B-STARD3-ERBB2-GRB7 amplicon on human chromosome 17q12, encodes the seven-transmembrane receptor with extracellular six-cysteine domain. (PubMed id 12739007)1, 3, 9 Katoh M. and Katoh M. (Int. J. Oncol. 2003)
    4. Solution structure of the oncogenic MIEN1 protein reveals a thioredoxin-like fold with a redox-active motif. (PubMed id 23284973)1, 2 Hsu C.H.... Huang L.Y. (PLoS ONE 2012)
    5. Novel gene C17orf37 in 17q12 amplicon promotes migration and invasion of prostate cancer cells. (PubMed id 19503095)1, 2 Dasgupta S....Vishwanatha J.K. (Oncogene 2009)
    6. SelT, SelW, SelH, and Rdx12: genomics and molecular insights into the functions of selenoproteins of a novel thioredoxin-like family. (PubMed id 17503775)1, 3 Dikiy A....Gladyshev V.N. (Biochemistry 2007)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. HapMap-based study of the 17q21 ERBB2 amplicon in susceptibility to breast cancer. (PubMed id 17117180)1, 9 Benusiglio P.R....Ponder B.A. (Br. J. Cancer 2006)
    9. The interaction between C35 and I9Np73 promotes chemo-resistance in ovarian cancer cells. (PubMed id 23880825)1 Leung T.H....Ngan H.Y. (Br. J. Cancer 2013)
    10. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84299 HGNC: 28230 AceView: C17orf37 Ensembl:ENSG00000141741 euGenes: HUgn84299
    ECgene: MIEN1 H-InvDB: MIEN1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MIEN1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MIEN1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MIEN1 gene:
    Search GeneIP for patents involving MIEN1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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