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Aliases for MIEN1 Gene

Subcategory (RNA class) for MIEN1 Gene

antisense

Aliases for MIEN1 Gene

  • Migration And Invasion Enhancer 1 2 3 5
  • HBV X-Transactivated Gene 4 Protein 3 4
  • HBV XAg-Transactivated Protein 4 3 4
  • C17orf37 3 4
  • RDX12 3 4
  • XTP4 3 4
  • Chromosome 17 Open Reading Frame 37 2
  • Protein C17orf37 3
  • Protein C35 4
  • ORB3 3
  • C35 3

External Ids for MIEN1 Gene

ORGUL Members for MIEN1 Gene

Previous HGNC Symbols for MIEN1 Gene

  • C17orf37

Previous GeneCards Identifiers for MIEN1 Gene

  • GC17M037886

Summaries for MIEN1 Gene

GeneCards Summary for MIEN1 Gene

MIEN1 (Migration And Invasion Enhancer 1) is a Protein Coding gene, and is affiliated with the antisense RNA class. GO annotations related to this gene include selenium binding.

UniProtKB/Swiss-Prot for MIEN1 Gene

  • Increases cell migration by inducing filopodia formation at the leading edge of migrating cells. Plays a role in regulation of apoptosis, possibly through control of CASP3. May be involved in a redox-related process.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIEN1 Gene

Genomics for MIEN1 Gene

Regulatory Elements for MIEN1 Gene

Enhancers for MIEN1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MIEN1 on UCSC Golden Path with GeneCards custom track

Promoters for MIEN1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MIEN1 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIEN1 Gene

Chromosome:
17
Start:
39,728,496 bp from pter
End:
39,730,787 bp from pter
Size:
2,292 bases
Orientation:
Minus strand

Genomic View for MIEN1 Gene

Genes around MIEN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIEN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIEN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIEN1 Gene

Proteins for MIEN1 Gene

  • Protein details for MIEN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BRT3-MIEN1_HUMAN
    Recommended name:
    Migration and invasion enhancer 1
    Protein Accession:
    Q9BRT3

    Protein attributes for MIEN1 Gene

    Size:
    115 amino acids
    Molecular mass:
    12403 Da
    Quaternary structure:
    • Interacts with GPX1.

    Three dimensional structures from OCA and Proteopedia for MIEN1 Gene

neXtProt entry for MIEN1 Gene

Proteomics data for MIEN1 Gene at MOPED

Post-translational modifications for MIEN1 Gene

  • Isoprenylation facilitates association with the plasma membrane and enhances the migratory phenotype of cells by inducing increased filopodia formation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MIEN1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MIEN1 Gene

Domains & Families for MIEN1 Gene

Protein Domains for MIEN1 Gene

Suggested Antigen Peptide Sequences for MIEN1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BRT3

UniProtKB/Swiss-Prot:

MIEN1_HUMAN :
  • Belongs to the SelWTH family.
Family:
  • Belongs to the SelWTH family.
genes like me logo Genes that share domains with MIEN1: view

No data available for Gene Families for MIEN1 Gene

Function for MIEN1 Gene

Molecular function for MIEN1 Gene

UniProtKB/Swiss-Prot Function:
Increases cell migration by inducing filopodia formation at the leading edge of migrating cells. Plays a role in regulation of apoptosis, possibly through control of CASP3. May be involved in a redox-related process.

Phenotypes for MIEN1 Gene

genes like me logo Genes that share phenotypes with MIEN1: view

Animal Model Products

CRISPR Products

miRNA for MIEN1 Gene

miRTarBase miRNAs that target MIEN1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MIEN1 Gene

Localization for MIEN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIEN1 Gene

Cytoplasm, cytosol. Cell membrane; Lipid-anchor; Cytoplasmic side. Note=Concentrates at the leading edge of migrating cells. Localizes outside membrane raft regions.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MIEN1 Gene COMPARTMENTS Subcellular localization image for MIEN1 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5
plasma membrane 5
cytoskeleton 2

Gene Ontology (GO) - Cellular Components for MIEN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with MIEN1: view

Pathways & Interactions for MIEN1 Gene

SuperPathways for MIEN1 Gene

No Data Available

Interacting Proteins for MIEN1 Gene

Selected Interacting proteins: Q9BRT3-MIEN1_HUMAN for MIEN1 Gene via UniProtKB

Symbol External ID(s) Details
REL

Gene Ontology (GO) - Biological Process for MIEN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051491 positive regulation of filopodium assembly IDA 21628459
genes like me logo Genes that share ontologies with MIEN1: view

No data available for Pathways by source and SIGNOR curated interactions for MIEN1 Gene

Drugs & Compounds for MIEN1 Gene

No Compound Related Data Available

Transcripts for MIEN1 Gene

Unigene Clusters for MIEN1 Gene

Migration and invasion enhancer 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MIEN1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b
SP1: -
SP2: -
SP3: -
SP4:
SP5:

Relevant External Links for MIEN1 Gene

GeneLoc Exon Structure for
MIEN1
ECgene alternative splicing isoforms for
MIEN1

Expression for MIEN1 Gene

mRNA expression in normal human tissues for MIEN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MIEN1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (10.2), Cervix (8.6), and Fetal Brain (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MIEN1 Gene



SOURCE GeneReport for Unigene cluster for MIEN1 Gene Hs.333526

mRNA Expression by UniProt/SwissProt for MIEN1 Gene

Q9BRT3-MIEN1_HUMAN
Tissue specificity: Among normal tissues, present only in Leydig cells. Strongly up-regulated in breast cancers and in brain cancer distant metastasis (at protein level). Up-regulated in prostate cancer cells and in the higher grades of prostate adenocarcinoma (at protein level).
genes like me logo Genes that share expression patterns with MIEN1: view

Protein tissue co-expression partners for MIEN1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for MIEN1 Gene

Orthologs for MIEN1 Gene

This gene was present in the common ancestor of animals.

Orthologs for MIEN1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MIEN1 35
  • 91.3 (n)
  • 93.91 (a)
MIEN1 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MIEN1 35
  • 92.75 (n)
  • 95.65 (a)
C17ORF37 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mien1 35
  • 88.7 (n)
  • 89.57 (a)
Mien1 16
Mien1 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MIEN1 35
  • 98.84 (n)
  • 99.13 (a)
MIEN1 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MIEN1 36
  • 51 (a)
OneToOne
chicken
(Gallus gallus)
Aves MIEN1 35
  • 71.49 (n)
  • 69.88 (a)
MIEN1 36
  • 54 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MIEN1 36
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mien1 35
  • 75.99 (n)
  • 78.49 (a)
Str.15598 35
zebrafish
(Danio rerio)
Actinopterygii sepw2a 35
  • 62.77 (n)
  • 53.19 (a)
sepw2a 36
  • 53 (a)
OneToMany
sepw2b 36
  • 47 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8692 35
fruit fly
(Drosophila melanogaster)
Insecta CG15456 36
  • 35 (a)
OneToOne
Species with no ortholog for MIEN1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIEN1 Gene

ENSEMBL:
Gene Tree for MIEN1 (if available)
TreeFam:
Gene Tree for MIEN1 (if available)

Paralogs for MIEN1 Gene

(1) SIMAP similar genes for MIEN1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MIEN1: view

No data available for Paralogs for MIEN1 Gene

Variants for MIEN1 Gene

Sequence variations from dbSNP and Humsavar for MIEN1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs4252666 -- 39,729,274(+) GCTTT(C/T)GTGGG utr-variant-3-prime
rs3809717 -- 39,730,733(-) GTGGG(G/T)AAGCC upstream-variant-2KB
rs8071465 -- 39,731,373(+) cccgg(C/T)GCTGA upstream-variant-2KB
rs8066205 -- 39,731,048(+) agctt(A/C)ccgag upstream-variant-2KB
rs8066496 -- 39,731,210(+) atgag(A/C)caccg upstream-variant-2KB

Variation tolerance for MIEN1 Gene

Residual Variation Intolerance Score: 52.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.52; 11.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MIEN1 Gene

HapMap Linkage Disequilibrium report
MIEN1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MIEN1 Gene

Disorders for MIEN1 Gene

Relevant External Links for MIEN1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIEN1

No disorders were found for MIEN1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIEN1 Gene

Publications for MIEN1 Gene

  1. C35 (C17orf37) is a novel tumor biomarker abundantly expressed in breast cancer. (PMID: 17121940) Evans E.E. … Zauderer M. (Mol. Cancer Ther. 2006) 2 3 4 23 67
  2. MGC9753 gene, located within PPP1R1B-STARD3-ERBB2-GRB7 amplicon on human chromosome 17q12, encodes the seven-transmembrane receptor with extracellular six-cysteine domain. (PMID: 12739007) Katoh M. … Katoh M. (Int. J. Oncol. 2003) 2 3 23
  3. Prenylated c17orf37 induces filopodia formation to promote cell migration and metastasis. (PMID: 21628459) Dasgupta S. … Vishwanatha J.K. (J. Biol. Chem. 2011) 2 3
  4. SelT, SelW, SelH, and Rdx12: genomics and molecular insights into the functions of selenoproteins of a novel thioredoxin-like family. (PMID: 17503775) Dikiy A. … Gladyshev V.N. (Biochemistry 2007) 2 3
  5. HapMap-based study of the 17q21 ERBB2 amplicon in susceptibility to breast cancer. (PMID: 17117180) Benusiglio P.R. … Ponder B.A. (Br. J. Cancer 2006) 3 23

Products for MIEN1 Gene

Sources for MIEN1 Gene

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