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Aliases for MIEN1 Gene

Subcategory (RNA class) for MIEN1 Gene

antisense

Aliases for MIEN1 Gene

  • Migration And Invasion Enhancer 1 2 3 5
  • HBV X-Transactivated Gene 4 Protein 3 4
  • HBV XAg-Transactivated Protein 4 3 4
  • C17orf37 3 4
  • RDX12 3 4
  • XTP4 3 4
  • Chromosome 17 Open Reading Frame 37 2
  • Protein C17orf37 3
  • Protein C35 4
  • ORB3 3
  • C35 3

External Ids for MIEN1 Gene

ORGUL Members for MIEN1 Gene

Previous HGNC Symbols for MIEN1 Gene

  • C17orf37

Previous GeneCards Identifiers for MIEN1 Gene

  • GC17M037886

Summaries for MIEN1 Gene

GeneCards Summary for MIEN1 Gene

MIEN1 (Migration And Invasion Enhancer 1) is a Protein Coding gene, and is affiliated with the antisense RNA class. GO annotations related to this gene include selenium binding.

UniProtKB/Swiss-Prot for MIEN1 Gene

  • Increases cell migration by inducing filopodia formation at the leading edge of migrating cells. Plays a role in regulation of apoptosis, possibly through control of CASP3. May be involved in a redox-related process.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIEN1 Gene

Genomics for MIEN1 Gene

Regulatory Elements for MIEN1 Gene

Enhancers for MIEN1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G039698 1.9 FANTOM5 Ensembl ENCODE dbSUPER 12.2 +27.4 27414 8.8 PKNOX1 FOXA2 ARID4B SIN3A DMAP1 ZBTB7B YY1 FOS ZNF263 SP3 GRB7 PGAP3 MIEN1 NEUROD2 ERBB2 THRA ORMDL3 GSDMB MIR4728
GH17G039766 1.9 FANTOM5 Ensembl ENCODE dbSUPER 11.1 -44.1 -44101 17.2 HDGF PKNOX1 FOXA2 WRNIP1 SIN3A FEZF1 ZNF2 CBX5 FOS SP3 GSDMB ENSG00000266469 MED1 ORMDL3 GSDMA CDK12 ERBB2 MIEN1 GRB7 SNORA21
GH17G039694 1.5 Ensembl ENCODE dbSUPER 12.4 +35.0 35008 2.9 HNRNPUL1 FOXA2 MLX ARID4B DMAP1 ZNF48 YY1 TCF12 ZNF207 SP5 PGAP3 MIEN1 GRB7 NEUROD2 ORMDL3 LRRC3C ERBB2
GH17G039686 1.4 ENCODE dbSUPER 11.4 +42.6 42558 3.0 PKNOX1 MLX WRNIP1 ARID4B SIN3A DMAP1 YY1 ZNF143 ZNF207 KLF13 PGAP3 WIPF2 MIEN1 GRB7 STARD3 ENSG00000266469 MED1 ERBB2
GH17G039790 1.4 FANTOM5 ENCODE dbSUPER 11 -62.7 -62749 6.1 ZNF121 CBX5 ZNF207 RELB ETV6 IKZF2 BCLAF1 CREM CBFB CEBPB GSDMA IKZF3 GSDMB LRRC3C ZPBP2 GRB7 MIEN1 ORMDL3 PGAP3 ERBB2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIEN1 on UCSC Golden Path with GeneCards custom track

Promoters for MIEN1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000093980 287 1001 HNRNPUL1 MLX AGO1 ARID4B SIN3A ZNF2 SLC30A9 ZNF766 ZNF143 SP3

Genomic Location for MIEN1 Gene

Chromosome:
17
Start:
39,728,496 bp from pter
End:
39,730,787 bp from pter
Size:
2,292 bases
Orientation:
Minus strand

Genomic View for MIEN1 Gene

Genes around MIEN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIEN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIEN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIEN1 Gene

Proteins for MIEN1 Gene

  • Protein details for MIEN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BRT3-MIEN1_HUMAN
    Recommended name:
    Migration and invasion enhancer 1
    Protein Accession:
    Q9BRT3

    Protein attributes for MIEN1 Gene

    Size:
    115 amino acids
    Molecular mass:
    12403 Da
    Quaternary structure:
    • Interacts with GPX1.

    Three dimensional structures from OCA and Proteopedia for MIEN1 Gene

neXtProt entry for MIEN1 Gene

Post-translational modifications for MIEN1 Gene

  • Isoprenylation facilitates association with the plasma membrane and enhances the migratory phenotype of cells by inducing increased filopodia formation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MIEN1 Gene

Antibody Products

  • Abcam antibodies for MIEN1

No data available for DME Specific Peptides for MIEN1 Gene

Domains & Families for MIEN1 Gene

Protein Domains for MIEN1 Gene

Suggested Antigen Peptide Sequences for MIEN1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BRT3

UniProtKB/Swiss-Prot:

MIEN1_HUMAN :
  • Belongs to the SelWTH family.
Family:
  • Belongs to the SelWTH family.
genes like me logo Genes that share domains with MIEN1: view

No data available for Gene Families for MIEN1 Gene

Function for MIEN1 Gene

Molecular function for MIEN1 Gene

UniProtKB/Swiss-Prot Function:
Increases cell migration by inducing filopodia formation at the leading edge of migrating cells. Plays a role in regulation of apoptosis, possibly through control of CASP3. May be involved in a redox-related process.

Gene Ontology (GO) - Molecular Function for MIEN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with MIEN1: view

Phenotypes for MIEN1 Gene

genes like me logo Genes that share phenotypes with MIEN1: view

Animal Model Products

CRISPR Products

miRNA for MIEN1 Gene

miRTarBase miRNAs that target MIEN1

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MIEN1 Gene

Localization for MIEN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIEN1 Gene

Cytoplasm, cytosol. Cell membrane; Lipid-anchor; Cytoplasmic side. Note=Concentrates at the leading edge of migrating cells. Localizes outside membrane raft regions.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIEN1 gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytosol 5
nucleus 3
cytoskeleton 2

Gene Ontology (GO) - Cellular Components for MIEN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA,IEA 21628459
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane IDA 21628459
genes like me logo Genes that share ontologies with MIEN1: view

Pathways & Interactions for MIEN1 Gene

SuperPathways for MIEN1 Gene

No Data Available

Interacting Proteins for MIEN1 Gene

Gene Ontology (GO) - Biological Process for MIEN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0030335 positive regulation of cell migration IDA 21628459
GO:0043066 negative regulation of apoptotic process IDA 21068479
GO:0051491 positive regulation of filopodium assembly IDA 21628459
genes like me logo Genes that share ontologies with MIEN1: view

No data available for Pathways by source and SIGNOR curated interactions for MIEN1 Gene

Drugs & Compounds for MIEN1 Gene

No Compound Related Data Available

Transcripts for MIEN1 Gene

Unigene Clusters for MIEN1 Gene

Migration and invasion enhancer 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIEN1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b
SP1: -
SP2: -
SP3: -
SP4:
SP5:

Relevant External Links for MIEN1 Gene

GeneLoc Exon Structure for
MIEN1
ECgene alternative splicing isoforms for
MIEN1

Expression for MIEN1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIEN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MIEN1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (10.2), Cervix (8.6), and Fetal Brain (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MIEN1 Gene



Protein tissue co-expression partners for MIEN1 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIEN1 Gene:

MIEN1

SOURCE GeneReport for Unigene cluster for MIEN1 Gene:

Hs.333526

mRNA Expression by UniProt/SwissProt for MIEN1 Gene:

Q9BRT3-MIEN1_HUMAN
Tissue specificity: Among normal tissues, present only in Leydig cells. Strongly up-regulated in breast cancers and in brain cancer distant metastasis (at protein level). Up-regulated in prostate cancer cells and in the higher grades of prostate adenocarcinoma (at protein level).

Evidence on tissue expression from TISSUES for MIEN1 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with MIEN1: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIEN1 Gene

Orthologs for MIEN1 Gene

This gene was present in the common ancestor of animals.

Orthologs for MIEN1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MIEN1 34 35
  • 98.84 (n)
dog
(Canis familiaris)
Mammalia C17ORF37 35
  • 96 (a)
OneToOne
MIEN1 34
  • 92.75 (n)
cow
(Bos Taurus)
Mammalia MIEN1 34 35
  • 91.3 (n)
mouse
(Mus musculus)
Mammalia Mien1 34 16 35
  • 88.7 (n)
oppossum
(Monodelphis domestica)
Mammalia MIEN1 35
  • 51 (a)
OneToOne
chicken
(Gallus gallus)
Aves MIEN1 34 35
  • 71.49 (n)
lizard
(Anolis carolinensis)
Reptilia MIEN1 35
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mien1 34
  • 75.99 (n)
Str.15598 34
zebrafish
(Danio rerio)
Actinopterygii sepw2a 34 35
  • 62.77 (n)
sepw2b 35
  • 47 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8692 34
fruit fly
(Drosophila melanogaster)
Insecta CG15456 35
  • 35 (a)
OneToOne
Species where no ortholog for MIEN1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIEN1 Gene

ENSEMBL:
Gene Tree for MIEN1 (if available)
TreeFam:
Gene Tree for MIEN1 (if available)

Paralogs for MIEN1 Gene

(1) SIMAP similar genes for MIEN1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MIEN1: view

No data available for Paralogs for MIEN1 Gene

Variants for MIEN1 Gene

Sequence variations from dbSNP and Humsavar for MIEN1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000298507 -- 39,731,547(+) CCAGC(C/G)TCTCA upstream-variant-2KB
rs1003838197 -- 39,732,174(+) GCTCA(C/T)TTTTT upstream-variant-2KB
rs1003905622 -- 39,728,472(+) AGGAA(C/G)AGCAA intron-variant, nc-transcript-variant, utr-variant-3-prime
rs1004002141 -- 39,730,927(+) ATTTT(G/T)TTTTT upstream-variant-2KB
rs1004429073 -- 39,730,622(+) TCCGC(C/T)ACTGC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIEN1 Gene

Variant ID Type Subtype PubMed ID
nsv1056234 CNV gain 25217958
nsv1146669 OTHER inversion 26484159
nsv2048 CNV insertion 18451855

Variation tolerance for MIEN1 Gene

Residual Variation Intolerance Score: 52.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.52; 11.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MIEN1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIEN1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MIEN1 Gene

Disorders for MIEN1 Gene

Relevant External Links for MIEN1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIEN1

No disorders were found for MIEN1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIEN1 Gene

Publications for MIEN1 Gene

  1. C35 (C17orf37) is a novel tumor biomarker abundantly expressed in breast cancer. (PMID: 17121940) Evans E.E. … Zauderer M. (Mol. Cancer Ther. 2006) 2 3 4 22 64
  2. Prenylated c17orf37 induces filopodia formation to promote cell migration and metastasis. (PMID: 21628459) Dasgupta S. … Vishwanatha J.K. (J. Biol. Chem. 2011) 2 3 4 64
  3. MGC9753 gene, located within PPP1R1B-STARD3-ERBB2-GRB7 amplicon on human chromosome 17q12, encodes the seven-transmembrane receptor with extracellular six-cysteine domain. (PMID: 12739007) Katoh M. … Katoh M. (Int. J. Oncol. 2003) 2 3 22 64
  4. Solution structure of the oncogenic MIEN1 protein reveals a thioredoxin-like fold with a redox-active motif. (PMID: 23284973) Hsu C.H. … Huang L.Y. (PLoS ONE 2012) 3 4 64
  5. Novel gene C17orf37 in 17q12 amplicon promotes migration and invasion of prostate cancer cells. (PMID: 19503095) Dasgupta S. … Vishwanatha J.K. (Oncogene 2009) 3 4 64

Products for MIEN1 Gene

Sources for MIEN1 Gene

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