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Aliases for MIEF1 Gene

Aliases for MIEF1 Gene

  • Mitochondrial Elongation Factor 1 2 3 4
  • Smith-Magenis Syndrome Chromosomal Region Candidate Gene 7 Protein-Like 3 4
  • Smith-Magenis Syndrome Chromosome Region, Candidate 7-Like 2 3
  • Mitochondrial Dynamics Protein Of 51 KDa 3 4
  • SMCR7-Like Protein 3 4
  • SMCR7L 3 4
  • MID51 3 4
  • Mitochondrial Dynamic Protein Of 51 KDa 3
  • Mitochondrial Dynamic Protein MID51 3
  • DJ1104E15.3 3
  • HSU79252 3

External Ids for MIEF1 Gene

Previous HGNC Symbols for MIEF1 Gene

  • SMCR7L

Previous GeneCards Identifiers for MIEF1 Gene

  • GC22P039896

Summaries for MIEF1 Gene

GeneCards Summary for MIEF1 Gene

MIEF1 (Mitochondrial Elongation Factor 1) is a Protein Coding gene. GO annotations related to this gene include identical protein binding and ADP binding. An important paralog of this gene is MIEF2.

UniProtKB/Swiss-Prot for MIEF1 Gene

  • Mitochondrial outer membrane protein which regulates mitochondrial fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface independently of the mitochondrial fission FIS1 and MFF proteins. Regulates DNM1L GTPase activity and DNM1L oligomerization. Binds ADP and can also bind GDP, although with lower affinity. Does not bind CDP, UDP, ATP, AMP or GTP. Inhibits DNM1L GTPase activity in the absence of bound ADP. Requires ADP to stimulate DNM1L GTPase activity and the assembly of DNM1L into long, oligomeric tubules with a spiral pattern, as opposed to the ring-like DNM1L oligomers observed in the absence of bound ADP. Does not require ADP for its function in recruiting DNM1L.

Gene Wiki entry for MIEF1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIEF1 Gene

Genomics for MIEF1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MIEF1 Gene

Chromosome:
22
Start:
39,499,432 bp from pter
End:
39,518,134 bp from pter
Size:
18,703 bases
Orientation:
Plus strand

Genomic View for MIEF1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIEF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIEF1 Gene

No data available for Regulatory Elements for MIEF1 Gene

Proteins for MIEF1 Gene

  • Protein details for MIEF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NQG6-MID51_HUMAN
    Recommended name:
    Mitochondrial dynamics protein MID51
    Protein Accession:
    Q9NQG6
    Secondary Accessions:
    • Q7L890
    • Q9BUI3

    Protein attributes for MIEF1 Gene

    Size:
    463 amino acids
    Molecular mass:
    51293 Da
    Quaternary structure:
    • Homodimer. Interacts with DNM1L.

    Three dimensional structures from OCA and Proteopedia for MIEF1 Gene

    Alternative splice isoforms for MIEF1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MIEF1 Gene

Proteomics data for MIEF1 Gene at MOPED

Post-translational modifications for MIEF1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MIEF1 Gene

No data available for DME Specific Peptides for MIEF1 Gene

Domains & Families for MIEF1 Gene

Protein Domains for MIEF1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MIEF1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NQG6

UniProtKB/Swiss-Prot:

MID51_HUMAN :
  • Belongs to the SMCR7 family.
Family:
  • Belongs to the SMCR7 family.
genes like me logo Genes that share domains with MIEF1: view

No data available for Gene Families for MIEF1 Gene

Function for MIEF1 Gene

Molecular function for MIEF1 Gene

UniProtKB/Swiss-Prot Function:
Mitochondrial outer membrane protein which regulates mitochondrial fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface independently of the mitochondrial fission FIS1 and MFF proteins. Regulates DNM1L GTPase activity and DNM1L oligomerization. Binds ADP and can also bind GDP, although with lower affinity. Does not bind CDP, UDP, ATP, AMP or GTP. Inhibits DNM1L GTPase activity in the absence of bound ADP. Requires ADP to stimulate DNM1L GTPase activity and the assembly of DNM1L into long, oligomeric tubules with a spiral pattern, as opposed to the ring-like DNM1L oligomers observed in the absence of bound ADP. Does not require ADP for its function in recruiting DNM1L.

Gene Ontology (GO) - Molecular Function for MIEF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0019003 GDP binding IDA 24515348
GO:0042802 identical protein binding IPI 21701560
GO:0043531 ADP binding IDA 24515348
genes like me logo Genes that share ontologies with MIEF1: view

Phenotypes for MIEF1 Gene

GenomeRNAi human phenotypes for MIEF1:
genes like me logo Genes that share phenotypes with MIEF1: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MIEF1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for MIEF1 Gene

Localization for MIEF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIEF1 Gene

Mitochondrion outer membrane; Single-pass membrane protein.

Gene Ontology (GO) - Cellular Components for MIEF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA 23921378
GO:0005741 mitochondrial outer membrane IDA 21508961
GO:0005777 NOT peroxisome TAS 23921378
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MIEF1: view

No data available for Subcellular locations from COMPARTMENTS for MIEF1 Gene

Pathways & Interactions for MIEF1 Gene

SuperPathways for MIEF1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIEF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000266 mitochondrial fission IMP 21701560
GO:0008053 NOT mitochondrial fusion IMP 23921378
GO:0090141 positive regulation of mitochondrial fission TAS 23921378
GO:0090314 NOT positive regulation of protein targeting to membrane IDA 23921378
genes like me logo Genes that share ontologies with MIEF1: view

No data available for Pathways by source and SIGNOR curated interactions for MIEF1 Gene

Drugs & Compounds for MIEF1 Gene

No Compound Related Data Available

Transcripts for MIEF1 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MIEF1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIEF1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d · 4e · 4f ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d · 8e ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b ^
SP1: - - - - - - -
SP2: - - - -
SP3: - -
SP4:
SP5: - - - - -
SP6: - - - - - - - - - - - - - - -
SP7: - - - - - - - - - -
SP8: - - - -
SP9: - - - - -
SP10: - - - - - - - - -
SP11: -
SP12: - - - - - - - -
SP13: - - - - - - - - - -
SP14: - -
SP15: - - -
SP16:
SP17:

ExUns: 13a · 13b · 13c ^ 14a · 14b · 14c · 14d · 14e · 14f ^ 15
SP1:
SP2: -
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:

Relevant External Links for MIEF1 Gene

GeneLoc Exon Structure for
MIEF1
ECgene alternative splicing isoforms for
MIEF1

Expression for MIEF1 Gene

mRNA expression in normal human tissues for MIEF1 Gene

Protein differential expression in normal tissues from HIPED for MIEF1 Gene

This gene is overexpressed in Bone (34.3) and Peripheral blood mononuclear cells (20.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MIEF1 Gene



mRNA Expression by UniProt/SwissProt for MIEF1 Gene

Q9NQG6-MID51_HUMAN
Tissue specificity: Expression is relatively high in heart, skeletal muscle, pancreas and kidney.
genes like me logo Genes that share expression patterns with MIEF1: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein tissue co-expression partners for MIEF1 Gene

Orthologs for MIEF1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIEF1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SMCR7L 35
  • 91.58 (n)
  • 96.76 (a)
MIEF1 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SMCR7L 35
  • 93.66 (n)
  • 98.06 (a)
MIEF1 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mief1 35
  • 90.78 (n)
  • 97.84 (a)
Smcr7l 16
Mief1 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SMCR7L 35
  • 99.64 (n)
  • 99.57 (a)
MIEF1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mief1 35
  • 91.5 (n)
  • 98.06 (a)
oppossum
(Monodelphis domestica)
Mammalia MIEF1 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MIEF1 36
  • 90 (a)
OneToOne
chicken
(Gallus gallus)
Aves SMCR7L 35
  • 78.76 (n)
  • 86.39 (a)
MIEF1 36
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MIEF1 36
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mief1 35
  • 68.91 (n)
  • 74.57 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.14488 35
zebrafish
(Danio rerio)
Actinopterygii mief1 35
  • 67.39 (n)
  • 71.68 (a)
mief1 36
  • 70 (a)
OneToOne
Species with no ortholog for MIEF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIEF1 Gene

ENSEMBL:
Gene Tree for MIEF1 (if available)
TreeFam:
Gene Tree for MIEF1 (if available)

Paralogs for MIEF1 Gene

Paralogs for MIEF1 Gene

(3) SIMAP similar genes for MIEF1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with MIEF1: view

Variants for MIEF1 Gene

Sequence variations from dbSNP and Humsavar for MIEF1 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs710192 -- 39,517,415(+) GCCCA(C/T)GGTCT utr-variant-3-prime, nc-transcript-variant
rs738288 -- 39,511,656(+) ATGAC(A/G)TGGAT intron-variant
rs1048310 -- 39,517,277(+) TTATT(G/T)TGGTT utr-variant-3-prime, nc-transcript-variant
rs2232085 -- 39,511,074(+) TTCCT(A/G)CAATA intron-variant
rs2232086 -- 39,511,077(+) CTACA(A/G)TACCC intron-variant

Variation tolerance for MIEF1 Gene

Residual Variation Intolerance Score: 32.18% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.14; 75.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MIEF1 Gene

HapMap Linkage Disequilibrium report
MIEF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MIEF1 Gene

Disorders for MIEF1 Gene

Relevant External Links for MIEF1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIEF1
genes like me logo Genes that share disorders with MIEF1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIEF1 Gene

Publications for MIEF1 Gene

  1. Human MIEF1 recruits Drp1 to mitochondrial outer membranes and promotes mitochondrial fusion rather than fission. (PMID: 21701560) Zhao J. … Nister M. (EMBO J. 2011) 2 67
  2. MiD49 and MiD51, new components of the mitochondrial fission machinery. (PMID: 21508961) Palmer C.S. … Ryan M.T. (EMBO Rep. 2011) 2 67
  3. Translation of 5' leaders is pervasive in genes resistant to eIF2 repression. (PMID: 25621764) Andreev D.E. … Baranov P.V. (Elife 2015) 67
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  5. Structural and functional analysis of MiD51, a dynamin receptor required for mitochondrial fission. (PMID: 24515348) Richter V. … Ryan M.T. (J. Cell Biol. 2014) 67

Products for MIEF1 Gene

Sources for MIEF1 Gene

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