Aliases for MIEF1 Gene
External Ids for MIEF1 Gene
Previous HGNC Symbols for MIEF1 Gene
Previous GeneCards Identifiers for MIEF1 Gene
GeneCards Summary for MIEF1 Gene
MIEF1 (Mitochondrial Elongation Factor 1) is a Protein Coding gene. GO annotations related to this gene include identical protein binding and ADP binding. An important paralog of this gene is MIEF2.
UniProtKB/Swiss-Prot for MIEF1 Gene
Mitochondrial outer membrane protein which regulates mitochondrial fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface independently of the mitochondrial fission FIS1 and MFF proteins. Regulates DNM1L GTPase activity and DNM1L oligomerization. Binds ADP and can also bind GDP, although with lower affinity. Does not bind CDP, UDP, ATP, AMP or GTP. Inhibits DNM1L GTPase activity in the absence of bound ADP. Requires ADP to stimulate DNM1L GTPase activity and the assembly of DNM1L into long, oligomeric tubules with a spiral pattern, as opposed to the ring-like DNM1L oligomers observed in the absence of bound ADP. Does not require ADP for its function in recruiting DNM1L.