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Aliases for MIEF1 Gene

Aliases for MIEF1 Gene

  • Mitochondrial Elongation Factor 1 2 3 4
  • SMCR7L 3 4 6
  • MID51 3 4 6
  • Smith-Magenis Syndrome Chromosomal Region Candidate Gene 7 Protein-Like 3 4
  • Smith-Magenis Syndrome Chromosome Region, Candidate 7-Like 2 3
  • Mitochondrial Dynamics Protein Of 51 KDa 3 4
  • SMCR7-Like Protein 3 4
  • Mitochondrial Dynamic Protein Of 51 KDa 3
  • Mitochondrial Dynamics Protein MID51 3
  • Mitochondrial Dynamic Protein MID51 3
  • DJ1104E15.3 3
  • HSU79252 3
  • MEIF1 6

External Ids for MIEF1 Gene

Previous HGNC Symbols for MIEF1 Gene

  • SMCR7L

Previous GeneCards Identifiers for MIEF1 Gene

  • GC22P039896

Summaries for MIEF1 Gene

GeneCards Summary for MIEF1 Gene

MIEF1 (Mitochondrial Elongation Factor 1) is a Protein Coding gene. Diseases associated with MIEF1 include smith-magenis syndrome. GO annotations related to this gene include identical protein binding. An important paralog of this gene is MIEF2.

UniProtKB/Swiss-Prot for MIEF1 Gene

  • Mitochondrial outer membrane protein which regulates mitochondrial fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface independently of the mitochondrial fission FIS1 and MFF proteins. Regulates DNM1L GTPase activity and DNM1L oligomerization. Binds ADP and can also bind GDP, although with lower affinity. Does not bind CDP, UDP, ATP, AMP or GTP. Inhibits DNM1L GTPase activity in the absence of bound ADP. Requires ADP to stimulate DNM1L GTPase activity and the assembly of DNM1L into long, oligomeric tubules with a spiral pattern, as opposed to the ring-like DNM1L oligomers observed in the absence of bound ADP. Does not require ADP for its function in recruiting DNM1L.

Gene Wiki entry for MIEF1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIEF1 Gene

Genomics for MIEF1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MIEF1 Gene

Start:
39,499,432 bp from pter
End:
39,518,134 bp from pter
Size:
18,703 bases
Orientation:
Plus strand

Genomic View for MIEF1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIEF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIEF1 Gene

No data available for Regulatory Elements for MIEF1 Gene

Proteins for MIEF1 Gene

  • Protein details for MIEF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NQG6-MID51_HUMAN
    Recommended name:
    Mitochondrial dynamics protein MID51
    Protein Accession:
    Q9NQG6
    Secondary Accessions:
    • Q7L890
    • Q9BUI3

    Protein attributes for MIEF1 Gene

    Size:
    463 amino acids
    Molecular mass:
    51293 Da
    Quaternary structure:
    • Homodimer. Interacts with DNM1L.

    Three dimensional structures from OCA and Proteopedia for MIEF1 Gene

    Alternative splice isoforms for MIEF1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MIEF1 Gene

Proteomics data for MIEF1 Gene at MOPED

Post-translational modifications for MIEF1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MIEF1 Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for MIEF1

No data available for DME Specific Peptides for MIEF1 Gene

Domains for MIEF1 Gene

Protein Domains for MIEF1 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9NQG6

UniProtKB/Swiss-Prot:

MID51_HUMAN :
  • Q9NQG6
Family:
  • Belongs to the SMCR7 family.
genes like me logo Genes that share domains with MIEF1: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for MIEF1 Gene

Function for MIEF1 Gene

Molecular function for MIEF1 Gene

UniProtKB/Swiss-Prot Function:
Mitochondrial outer membrane protein which regulates mitochondrial fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface independently of the mitochondrial fission FIS1 and MFF proteins. Regulates DNM1L GTPase activity and DNM1L oligomerization. Binds ADP and can also bind GDP, although with lower affinity. Does not bind CDP, UDP, ATP, AMP or GTP. Inhibits DNM1L GTPase activity in the absence of bound ADP. Requires ADP to stimulate DNM1L GTPase activity and the assembly of DNM1L into long, oligomeric tubules with a spiral pattern, as opposed to the ring-like DNM1L oligomers observed in the absence of bound ADP. Does not require ADP for its function in recruiting DNM1L.

Gene Ontology (GO) - Molecular Function for MIEF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0019003 GDP binding IDA 24515348
GO:0042802 identical protein binding IPI 21701560
GO:0043531 ADP binding IDA 24515348
genes like me logo Genes that share ontologies with MIEF1: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MIEF1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for MIEF1 Gene

Localization for MIEF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIEF1 Gene

Mitochondrion outer membrane; Single-pass membrane protein.

Gene Ontology (GO) - Cellular Components for MIEF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA --
GO:0005741 mitochondrial outer membrane IDA 21508961
GO:0005777 NOT peroxisome TAS 23921378
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MIEF1: view

No data available for Subcellular locations from COMPARTMENTS for MIEF1 Gene

Pathways for MIEF1 Gene

SuperPathways for MIEF1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIEF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000266 mitochondrial fission IMP 21701560
GO:0008053 NOT mitochondrial fusion IMP 23921378
GO:0090141 positive regulation of mitochondrial fission TAS 23921378
GO:0090314 NOT positive regulation of protein targeting to membrane IDA 23921378
genes like me logo Genes that share ontologies with MIEF1: view

No data available for Pathways by source for MIEF1 Gene

Transcripts for MIEF1 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MIEF1

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIEF1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d · 4e · 4f ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d · 8e ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b ^
SP1: - - - - - - -
SP2: - - - -
SP3: - -
SP4:
SP5: - - - - -
SP6: - - - - - - - - - - - - - - -
SP7: - - - - - - - - - -
SP8: - - - -
SP9: - - - - -
SP10: - - - - - - - - -
SP11: -
SP12: - - - - - - - -
SP13: - - - - - - - - - -
SP14: - -
SP15: - - -
SP16:
SP17:

ExUns: 13a · 13b · 13c ^ 14a · 14b · 14c · 14d · 14e · 14f ^ 15
SP1:
SP2: -
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:

Relevant External Links for MIEF1 Gene

GeneLoc Exon Structure for
MIEF1
ECgene alternative splicing isoforms for
MIEF1

Expression for MIEF1 Gene

mRNA expression in normal human tissues for MIEF1 Gene

Protein differential expression in normal tissues for MIEF1 Gene

This gene is overexpressed in Bone (34.3) and Peripheral blood mononuclear cells (20.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for MIEF1 Gene

mRNA Expression by UniProt/SwissProt for MIEF1 Gene

Q9NQG6-MID51_HUMAN
Tissue specificity: Expression is relatively high in heart, skeletal muscle, pancreas and kidney.
genes like me logo Genes that share expressions with MIEF1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Expression partners for MIEF1 Gene

Orthologs for MIEF1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIEF1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SMCR7L 35
  • 91.58 (n)
  • 96.76 (a)
MIEF1 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SMCR7L 35
  • 93.66 (n)
  • 98.06 (a)
MIEF1 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mief1 35
  • 90.78 (n)
  • 97.84 (a)
Smcr7l 16
Mief1 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SMCR7L 35
  • 99.64 (n)
  • 99.57 (a)
MIEF1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mief1 35
  • 91.5 (n)
  • 98.06 (a)
oppossum
(Monodelphis domestica)
Mammalia MIEF1 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MIEF1 36
  • 90 (a)
OneToOne
chicken
(Gallus gallus)
Aves SMCR7L 35
  • 78.76 (n)
  • 86.39 (a)
MIEF1 36
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MIEF1 36
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mief1 35
  • 68.91 (n)
  • 74.57 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.14488 35
zebrafish
(Danio rerio)
Actinopterygii mief1 35
  • 67.39 (n)
  • 71.68 (a)
mief1 36
  • 70 (a)
OneToOne
Species with no ortholog for MIEF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIEF1 Gene

ENSEMBL:
Gene Tree for MIEF1 (if available)
TreeFam:
Gene Tree for MIEF1 (if available)

Paralogs for MIEF1 Gene

Paralogs for MIEF1 Gene

Selected SIMAP similar genes for MIEF1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with MIEF1: view

Variants for MIEF1 Gene

Sequence variations from dbSNP and Humsavar for MIEF1 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs710192 -- 39,517,415(+) GCCCA(C/T)GGTCT utr-variant-3-prime
rs738288 -- 39,511,656(+) ATGAC(A/G)TGGAT intron-variant
rs742143 -- 39,503,940(-) ACCCC(C/T)GCTGA intron-variant
rs1048310 -- 39,517,277(+) TTATT(G/T)TGGTT utr-variant-3-prime
rs2232085 -- 39,511,074(+) TTCCT(A/G)CAATA intron-variant

Relevant External Links for MIEF1 Gene

HapMap Linkage Disequilibrium report
MIEF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MIEF1 Gene

Disorders for MIEF1 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for MIEF1 Gene in MalaCards »

(1) Diseases for MIEF1 Gene including...

genes like me logo Genes that share disorders with MIEF1: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for MIEF1 Gene

Publications for MIEF1 Gene

  1. MiD49 and MiD51, new components of the mitochondrial fission machinery. (PMID: 21508961) Palmer C.S. … Ryan M.T. (EMBO Rep. 2011) 2 3 4
  2. Human MIEF1 recruits Drp1 to mitochondrial outer membranes and promotes mitochondrial fusion rather than fission. (PMID: 21701560) Zhao J. … Nister M. (EMBO J. 2011) 2 3 4
  3. Fis1, Mff, MiD49, and MiD51 mediate Drp1 recruitment in mitochondrial fission. (PMID: 23283981) LosA^n O.C. … Chan D.C. (Mol. Biol. Cell 2013) 3 4
  4. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 3 4
  5. MiD49 and MiD51 can act independently of Mff and Fis1 in Drp1 recruitment and are specific for mitochondrial fission. (PMID: 23921378) Palmer C.S. … Ryan M.T. (J. Biol. Chem. 2013) 3 4

Products for MIEF1 Gene

Sources for MIEF1 Gene

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