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Aliases for MIDN Gene

Aliases for MIDN Gene

  • Midnolin 2 3
  • Midbrain Nucleolar Protein 4

External Ids for MIDN Gene

Previous GeneCards Identifiers for MIDN Gene

  • GC19U990284
  • GC19P001319
  • GC19P001190
  • GC19P001201
  • GC19P001199
  • GC19P001020

Summaries for MIDN Gene

GeneCards Summary for MIDN Gene

MIDN (Midnolin) is a Protein Coding gene.

UniProtKB/Swiss-Prot for MIDN Gene

  • May be involved in regulation of genes related to neurogenesis in the nucleolus.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIDN Gene

Genomics for MIDN Gene

Regulatory Elements for MIDN Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MIDN Gene

Start:
1,248,553 bp from pter
End:
1,259,143 bp from pter
Size:
10,591 bases
Orientation:
Plus strand

Genomic View for MIDN Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIDN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIDN Gene

Proteins for MIDN Gene

  • Protein details for MIDN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q504T8-MIDN_HUMAN
    Recommended name:
    Midnolin
    Protein Accession:
    Q504T8
    Secondary Accessions:
    • Q96BW8

    Protein attributes for MIDN Gene

    Size:
    468 amino acids
    Molecular mass:
    49213 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MIDN Gene

Proteomics data for MIDN Gene at MOPED

Post-translational modifications for MIDN Gene

  • Ubiquitination at Lys84, Lys354, and Lys402
  • Modification sites at PhosphoSitePlus

Other Protein References for MIDN Gene

No data available for DME Specific Peptides for MIDN Gene

Domains for MIDN Gene

Protein Domains for MIDN Gene

Suggested Antigen Peptide Sequences for MIDN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q504T8

UniProtKB/Swiss-Prot:

MIDN_HUMAN :
  • Q504T8
Domain:
  • Contains 1 ubiquitin-like domain.
genes like me logo Genes that share domains with MIDN: view

No data available for Gene Families for MIDN Gene

Function for MIDN Gene

Molecular function for MIDN Gene

UniProtKB/Swiss-Prot Function: May be involved in regulation of genes related to neurogenesis in the nucleolus.

Gene Ontology (GO) - Molecular Function for MIDN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0019900 kinase binding IEA --
genes like me logo Genes that share ontologies with MIDN: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MIDN

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for MIDN Gene

Localization for MIDN Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIDN Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MIDN Gene COMPARTMENTS Subcellular localization image for MIDN gene
Compartment Confidence
nucleus 3
cytosol 1

Gene Ontology (GO) - Cellular Components for MIDN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005730 nucleolus IEA --
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with MIDN: view

Pathways for MIDN Gene

SuperPathways for MIDN Gene

No Data Available

Interacting Proteins for MIDN Gene

Gene Ontology (GO) - Biological Process for MIDN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0033132 negative regulation of glucokinase activity IEA --
GO:0046676 negative regulation of insulin secretion IEA --
genes like me logo Genes that share ontologies with MIDN: view

No data available for Pathways by source for MIDN Gene

Transcripts for MIDN Gene

Unigene Clusters for MIDN Gene

Midnolin:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MIDN

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIDN Gene

No ASD Table

Relevant External Links for MIDN Gene

GeneLoc Exon Structure for
MIDN
ECgene alternative splicing isoforms for
MIDN

Expression for MIDN Gene

mRNA expression in normal human tissues for MIDN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MIDN Gene

This gene is overexpressed in Whole Blood (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for MIDN Gene

SOURCE GeneReport for Unigene cluster for MIDN Gene Hs.465529

genes like me logo Genes that share expressions with MIDN: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for MIDN Gene

Orthologs for MIDN Gene

This gene was present in the common ancestor of animals.

Orthologs for MIDN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MIDN 35
  • 96.72 (n)
  • 95.95 (a)
cow
(Bos Taurus)
Mammalia MIDN 35
  • 87.61 (n)
  • 92.48 (a)
MIDN 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MIDN 35
  • 88.12 (n)
  • 92.39 (a)
MIDN 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Midn 35
  • 84.13 (n)
  • 93.07 (a)
Midn 16
Midn 36
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MIDN 36
  • 66 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Midn 35
  • 83.59 (n)
  • 92.81 (a)
lizard
(Anolis carolinensis)
Reptilia MIDN 36
  • 61 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC52897 35
tropical clawed frog
(Silurana tropicalis)
Amphibia midn 35
  • 63.43 (n)
  • 66.44 (a)
Str.7531 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2559 35
zebrafish
(Danio rerio)
Actinopterygii midn 35
  • 68.75 (n)
  • 78.75 (a)
midn 36
  • 59 (a)
OneToOne
wufc07f11 35
fruit fly
(Drosophila melanogaster)
Insecta CG32676 36
  • 15 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 35 (a)
OneToOne
Species with no ortholog for MIDN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIDN Gene

ENSEMBL:
Gene Tree for MIDN (if available)
TreeFam:
Gene Tree for MIDN (if available)

Paralogs for MIDN Gene

No data available for Paralogs for MIDN Gene

Variants for MIDN Gene

Sequence variations from dbSNP and Humsavar for MIDN Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs9823 -- 1,256,999(+) GGGGA(C/T)CGGCT reference, synonymous-codon
rs1859247 -- 1,257,538(+) TCCTC(C/T)GTCTG utr-variant-3-prime
rs2285811 -- 1,251,782(+) CCCCT(A/G)TTCCA intron-variant
rs2301760 -- 1,253,968(+) gcgcc(C/T)gggcc intron-variant, reference, synonymous-codon
rs2301761 -- 1,254,123(+) GGGGC(A/G)CCGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MIDN Gene

Variant ID Type Subtype PubMed ID
nsv910292 CNV Loss 21882294
dgv3555n71 CNV Loss 21882294
nsv9662 CNV Gain 18304495
dgv1055e1 CNV Complex 17122850
dgv3575n71 CNV Loss 21882294
dgv3580n71 CNV Loss 21882294
nsv470103 CNV Gain 18288195
nsv910420 CNV Loss 21882294
dgv3583n71 CNV Loss 21882294
dgv3585n71 CNV Loss 21882294
dgv3586n71 CNV Loss 21882294
nsv470104 CNV Loss 18288195
dgv3587n71 CNV Loss 21882294
nsv910442 CNV Gain+Loss 21882294
dgv3588n71 CNV Loss 21882294
dgv3589n71 CNV Loss 21882294
dgv3590n71 CNV Loss 21882294
dgv3591n71 CNV Loss 21882294
dgv3592n71 CNV Loss 21882294
nsv828368 CNV Gain 20364138
nsv910466 CNV Loss 21882294
dgv3594n71 CNV Loss 21882294
nsv910469 CNV Loss 21882294
nsv828369 CNV Gain 20364138
esv24381 CNV Loss 19812545
nsv910471 CNV Loss 21882294
dgv3595n71 CNV Loss 21882294
dgv3596n71 CNV Loss 21882294
nsv828370 CNV Loss 20364138
nsv828371 CNV Loss 20364138
nsv828372 CNV Gain 20364138

Relevant External Links for MIDN Gene

HapMap Linkage Disequilibrium report
MIDN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MIDN Gene

Disorders for MIDN Gene

(1) University of Copenhagen DISEASES for MIDN Gene

Relevant External Links for MIDN

Genetic Association Database (GAD)
MIDN
genes like me logo Genes that share disorders with MIDN: view

No data available for UniProtKB/Swiss-Prot for MIDN Gene

Publications for MIDN Gene

  1. Novel nucleolar protein, midnolin, is expressed in the mesencephalon during mouse development. (PMID: 10974535) Tsukahara M. … Tsunoo H. (Gene 2000) 2 3
  2. Human chromosome 19 and related regions in mouse: conservative and lineage-specific evolution. (PMID: 11441184) Dehal P. … Stubbs L. (Science 2001) 3
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  4. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3

Products for MIDN Gene

Sources for MIDN Gene

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