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Aliases for MIDN Gene

Aliases for MIDN Gene

  • Midnolin 2 3 5
  • Midbrain Nucleolar Protein 4

External Ids for MIDN Gene

Previous GeneCards Identifiers for MIDN Gene

  • GC19U990284
  • GC19P001319
  • GC19P001190
  • GC19P001201
  • GC19P001199
  • GC19P001020

Summaries for MIDN Gene

GeneCards Summary for MIDN Gene

MIDN (Midnolin) is a Protein Coding gene. GO annotations related to this gene include kinase binding.

UniProtKB/Swiss-Prot for MIDN Gene

  • May be involved in regulation of genes related to neurogenesis in the nucleolus.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIDN Gene

Genomics for MIDN Gene

Regulatory Elements for MIDN Gene

Enhancers for MIDN Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MIDN on UCSC Golden Path with GeneCards custom track

Genomic Location for MIDN Gene

1,248,553 bp from pter
1,259,143 bp from pter
10,591 bases
Plus strand

Genomic View for MIDN Gene

Genes around MIDN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIDN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIDN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIDN Gene

Proteins for MIDN Gene

  • Protein details for MIDN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q96BW8

    Protein attributes for MIDN Gene

    468 amino acids
    Molecular mass:
    49213 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MIDN Gene

Proteomics data for MIDN Gene at MOPED

Post-translational modifications for MIDN Gene

  • Ubiquitination at Lys 84, Lys 354, and Lys 402
  • Modification sites at PhosphoSitePlus

Other Protein References for MIDN Gene

No data available for DME Specific Peptides for MIDN Gene

Domains & Families for MIDN Gene

Protein Domains for MIDN Gene

Suggested Antigen Peptide Sequences for MIDN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 ubiquitin-like domain.
  • Contains 1 ubiquitin-like domain.
genes like me logo Genes that share domains with MIDN: view

No data available for Gene Families for MIDN Gene

Function for MIDN Gene

Molecular function for MIDN Gene

UniProtKB/Swiss-Prot Function:
May be involved in regulation of genes related to neurogenesis in the nucleolus.

Phenotypes for MIDN Gene

genes like me logo Genes that share phenotypes with MIDN: view

Animal Model Products

miRNA for MIDN Gene

miRTarBase miRNAs that target MIDN

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MIDN Gene

Localization for MIDN Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIDN Gene

Nucleus, nucleolus.

Subcellular locations from

Jensen Localization Image for MIDN Gene COMPARTMENTS Subcellular localization image for MIDN gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for MIDN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IEA --
genes like me logo Genes that share ontologies with MIDN: view

Pathways & Interactions for MIDN Gene

SuperPathways for MIDN Gene

No Data Available

Interacting Proteins for MIDN Gene

Gene Ontology (GO) - Biological Process for MIDN Gene


No data available for Pathways by source and SIGNOR curated interactions for MIDN Gene

Drugs & Compounds for MIDN Gene

No Compound Related Data Available

Transcripts for MIDN Gene

Unigene Clusters for MIDN Gene

Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MIDN Gene

No ASD Table

Relevant External Links for MIDN Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIDN Gene

mRNA expression in normal human tissues for MIDN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MIDN Gene

This gene is overexpressed in Whole Blood (x4.1).

Protein differential expression in normal tissues from HIPED for MIDN Gene

This gene is overexpressed in Urine (58.2) and NK cells (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MIDN Gene

SOURCE GeneReport for Unigene cluster for MIDN Gene Hs.465529

genes like me logo Genes that share expression patterns with MIDN: view

Protein tissue co-expression partners for MIDN Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for MIDN Gene

Orthologs for MIDN Gene

This gene was present in the common ancestor of animals.

Orthologs for MIDN Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MIDN 35
  • 87.61 (n)
  • 92.48 (a)
  • 84 (a)
(Canis familiaris)
Mammalia MIDN 35
  • 88.12 (n)
  • 92.39 (a)
  • 92 (a)
(Mus musculus)
Mammalia Midn 35
  • 84.13 (n)
  • 93.07 (a)
Midn 16
Midn 36
  • 85 (a)
(Pan troglodytes)
Mammalia MIDN 35
  • 96.72 (n)
  • 95.95 (a)
(Rattus norvegicus)
Mammalia Midn 35
  • 83.59 (n)
  • 92.81 (a)
(Monodelphis domestica)
Mammalia MIDN 36
  • 66 (a)
(Anolis carolinensis)
Reptilia MIDN 36
  • 61 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia midn 35
  • 63.43 (n)
  • 66.44 (a)
Str.7531 35
African clawed frog
(Xenopus laevis)
Amphibia MGC52897 35
(Danio rerio)
Actinopterygii midn 35
  • 68.75 (n)
  • 78.75 (a)
wufc07f11 35
midn 36
  • 59 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2559 35
fruit fly
(Drosophila melanogaster)
Insecta CG32676 36
  • 15 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 35 (a)
Species with no ortholog for MIDN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIDN Gene

Gene Tree for MIDN (if available)
Gene Tree for MIDN (if available)

Paralogs for MIDN Gene

No data available for Paralogs for MIDN Gene

Variants for MIDN Gene

Sequence variations from dbSNP and Humsavar for MIDN Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs7359860 -- 1,257,436(+) ttttt(A/T)AAAAA utr-variant-3-prime
rs7359976 -- 1,257,134(+) CGCAA(A/G)GCCGG reference, synonymous-codon
rs7359977 -- 1,257,272(+) GCTTA(A/G)GATCT reference, synonymous-codon
rs7507956 -- 1,252,421(+) AGGGG(A/G)GGGGG intron-variant
rs66531920 -- 1,252,416(+) CGAAA(-/G/GG)AGGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MIDN Gene

Variant ID Type Subtype PubMed ID
nsv910292 CNV Loss 21882294
dgv3555n71 CNV Loss 21882294
nsv9662 CNV Gain 18304495
dgv1055e1 CNV Complex 17122850
dgv3575n71 CNV Loss 21882294
dgv3580n71 CNV Loss 21882294
nsv470103 CNV Gain 18288195
nsv910420 CNV Loss 21882294
dgv3583n71 CNV Loss 21882294
dgv3585n71 CNV Loss 21882294
dgv3586n71 CNV Loss 21882294
nsv470104 CNV Loss 18288195
dgv3587n71 CNV Loss 21882294
nsv910442 CNV Gain+Loss 21882294
dgv3588n71 CNV Loss 21882294
dgv3589n71 CNV Loss 21882294
dgv3590n71 CNV Loss 21882294
dgv3591n71 CNV Loss 21882294
dgv3592n71 CNV Loss 21882294
nsv828368 CNV Gain 20364138
nsv910466 CNV Loss 21882294
dgv3594n71 CNV Loss 21882294
nsv910469 CNV Loss 21882294
nsv828369 CNV Gain 20364138
esv24381 CNV Loss 19812545
nsv910471 CNV Loss 21882294
dgv3595n71 CNV Loss 21882294
dgv3596n71 CNV Loss 21882294
nsv828370 CNV Loss 20364138
nsv828371 CNV Loss 20364138
nsv828372 CNV Gain 20364138

Variation tolerance for MIDN Gene

Residual Variation Intolerance Score: 28.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.73; 46.62% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for MIDN Gene

Disorders for MIDN Gene

Relevant External Links for MIDN

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MIDN Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIDN Gene

Publications for MIDN Gene

  1. Novel nucleolar protein, midnolin, is expressed in the mesencephalon during mouse development. (PMID: 10974535) Tsukahara M. … Tsunoo H. (Gene 2000) 2 3 67
  2. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  3. Identification of the ubiquitin-like domain of midnolin as a new glucokinase interaction partner. (PMID: 24187134) Hofmeister-Brix A. … Baltrusch S. (J. Biol. Chem. 2013) 3
  4. A directed protein interaction network for investigating intracellular signal transduction. (PMID: 21900206) Vinayagam A. … Wanker E.E. (Sci Signal 2011) 3
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3

Products for MIDN Gene

Sources for MIDN Gene