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MIDN Gene

protein-coding   GIFtS: 48
GCID: GC19P001248

Midnolin

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
midnolin1 2
Midbrain Nucleolar Protein2 3

External Ids:    HGNC: 162981   Entrez Gene: 900072   Ensembl: ENSG000001674707   OMIM: 6067005   UniProtKB: Q504T83   

Export aliases for MIDN gene to outside databases

Previous GC identifers: GC19U990284 GC19P001319 GC19P001190 GC19P001201 GC19P001199 GC19P001020


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MIDN Gene:
MIDN (midnolin) is a protein-coding gene. Diseases associated with MIDN include peutz-jeghers syndrome.

UniProtKB/Swiss-Prot: MIDN_HUMAN, Q504T8
Function: May be involved in regulation of genes related to neurogenesis in the nucleolus (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NT_011295.12  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MIDN gene promoter:
         Pax-5   Brachyury   Lmo2   Nkx2-5   NF-kappaB   E47   AREB6   ZID   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): MIDN promoter sequence
   Search Chromatin IP Primers for MIDN

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MIDN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

MIDN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MIDN gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P001248:  view genomic region     (about GC identifiers)

Start:
1,248,552 bp from pter      End:
1,259,142 bp from pter
Size:
10,591 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: MIDN_HUMAN, Q504T8 (See protein sequence)
Recommended Name: Midnolin  
Size: 468 amino acids; 49213 Da
Secondary accessions: Q96BW8

Explore the universe of human proteins at neXtProt for MIDN: NX_Q504T8

Explore proteomics data for MIDN at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys84, Lys354, Lys402
  • Modification sites at PhosphoSitePlus

  • See MIDN Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_796375.3  
    ENSEMBL proteins: 
     ENSP00000466895   ENSP00000467679   ENSP00000466835   ENSP00000300952  

    MIDN Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Protein Over-expression Lysate for MIDN
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    Novus Biologicals MIDN Proteins
    Novus Biologicals MIDN Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MIDN

    MIDN Antibody Products:

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    OriGene Antibodies for MIDN
    OriGene Custom Antibody Services for MIDN
    Novus Biologicals MIDN Antibodies
    Abcam antibodies for MIDN
    Cloud-Clone Corp. Antibodies for MIDN
    Search ThermoFisher Antibodies for MIDN
    Search LSBio for Antibodies for MIDN

    MIDN Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MIDN
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MIDN
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MIDN
    Cloud-Clone Corp. CLIAs for MIDN


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR000626 Ubiquitin_dom

    Graphical View of Domain Structure for InterPro Entry Q504T8

    ProtoNet protein and cluster: Q504T8

    1 Blocks protein domain: IPB000626 Ubiquitin domain

    UniProtKB/Swiss-Prot: MIDN_HUMAN, Q504T8
    Similarity: Contains 1 ubiquitin-like domain


    MIDN for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MIDN_HUMAN, Q504T8
    Function: May be involved in regulation of genes related to neurogenesis in the nucleolus (By similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    MIDN for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MIDN
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MIDN

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MIDN
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MIDN

    miRNA
    Products:
        
    miRTarBase miRNAs that target MIDN:
    hsa-mir-221-3p (MIRT024200), hsa-mir-425-5p (MIRT016654), hsa-mir-24-3p (MIRT030454), hsa-mir-93-5p (MIRT028077), hsa-let-7b-5p (MIRT052135), hsa-mir-130b-3p (MIRT020160)

    Block miRNA regulation of human, mouse, rat MIDN using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MIDN (see all 38):
    hsa-miR-136 hsa-miR-3607-3p hsa-miR-106a hsa-miR-485-3p hsa-miR-503 hsa-miR-519a hsa-miR-93 hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidMIDN 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MIDN
    Predesigned siRNA for gene silencing in human, mouse, rat MIDN

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MIDN

    Clone
    Products:
         
    OriGene clones in human, mouse for MIDN (see all 5)
    OriGene ORF clones in mouse, rat for MIDN
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MIDN (NM_177401)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MIDN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MIDN

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MIDN
    Browse ESI BIO Cell Lines and PureStem Progenitors for MIDN 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MIDN


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MIDN_HUMAN, Q504T8: Nucleus, nucleolus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005730nucleolus IEA--

    MIDN for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MIDN
    Interactions:

        Search GeneGlobe Interaction Network for MIDN

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    Selected Interacting proteins for MIDN (Q504T82, 3 ENSP000003009524) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GADD45AP245222, 3MINT-8255945 I2D: score=2 
    GADD45GO952572, 3MINT-8256217 I2D: score=2 
    ZAKQ9NYL22, 3MINT-8277310 I2D: score=2 
    HGSO149643I2D: score=4 
    MAP4K5Q9Y4K43I2D: score=2 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MIDN



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MIDN gene: 
    NM_177401.4  

    Unigene Cluster for MIDN:

    Midnolin
    Hs.465529  [show with all ESTs]
    Unigene Representative Sequence: NM_177401
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000586757 ENST00000591446 ENST00000591302 ENST00000586843 ENST00000590136
    ENST00000300952(uc002lrp.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MIDN using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MIDN (see all 38):
    hsa-miR-136 hsa-miR-3607-3p hsa-miR-106a hsa-miR-485-3p hsa-miR-503 hsa-miR-519a hsa-miR-93 hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidMIDN 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MIDN
    Predesigned siRNA for gene silencing in human, mouse, rat MIDN
    Clone
    Products:
         
    OriGene clones in human, mouse for MIDN (see all 5)
    OriGene ORF clones in mouse, rat for MIDN
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MIDN (NM_177401)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MIDN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MIDN
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for MIDN
    OriGene qSTAR qPCR primer pairs in human, mouse for MIDN
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MIDN
      QuantiTect SYBR Green Assays in human, mouse, rat MIDN
      QuantiFast Probe-based Assays in human, mouse, rat MIDN

    Additional mRNA sequence: 

    AK075506.1 AL512725.1 BC015089.2 BC060848.1 BC094778.1 

    16 DOTS entries:

    DT.450577  DT.97864632  DT.428255  DT.91859455  DT.100035137  DT.40273416  DT.40288563  DT.91676416 
    DT.100779551  DT.95125822  DT.95198507  DT.95362765  DT.100779545  DT.91746056  DT.91874872  DT.95272678 

    Selected AceView cDNA sequences (see all 278):

    BQ670856 AI918888 BM555587 AW340065 AI581091 AI079230 BF448887 AI568750 
    AW082990 AI142933 AI540078 AW016647 AA534608 AW135403 AI004697 AI239624 
    CR598784 AI918164 BU741795 AI870830 CB216641 AI300085 CA771108 AI560206 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MIDN expression in normal human tissues (normalized intensities)      MIDN embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATGAAAACA
    MIDN Expression
    About this image


    MIDN expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
    MIDN Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MIDN Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.465529
        Custom PCR Arrays for MIDN
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for MIDN
    OriGene qSTAR qPCR primer pairs in human, mouse for MIDN
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MIDN
    QuantiTect SYBR Green Assays in human, mouse, rat MIDN
    QuantiFast Probe-based Assays in human, mouse, rat MIDN
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MIDN

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MIDN gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Midn1 , 5 midnolin1, 5 84.13(n)1
    93.07(a)1
      10 (39.72 cM)5
    590901  NM_021565.11  NP_067540.11 
     801482725 
    lizard
    (Anolis carolinensis)
    Reptilia MIDN6
    midnolin
    61(a)
    1 ↔ 1
    GL344335.1(1510-7093)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC528972 similar to midnolin 74.55(n)    BC046658.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc07f112 Transcribed sequence with weak similarity to protein more 79.37(n)    CA474471.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG326766
    --
    15(a)
    1 ↔ 1
    X(10605196-10638938)


    ENSEMBL Gene Tree for MIDN (if available)
    TreeFam Gene Tree for MIDN (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MIDN (see all 411)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1157178531,2
    F--1246558(+) GGCAGG/CGAGGG 1 -- us2k11Minor allele frequency- C:0.01WA 118
    rs104107201,2
    C,F--1246636(+) TCCACG/AGCTCC 1 -- us2k14Minor allele frequency- A:0.26WA CSA 123
    rs1422540941,2
    --1246646(+) CCTCCA/GCCACC 1 -- us2k10--------
    rs1828007531,2
    --1246666(+) ACTGGA/CAGCAG 1 -- us2k10--------
    rs1862706641,2
    --1246684(+) CTGGCC/TCTGTA 1 -- us2k10--------
    rs1149270661,2
    F--1246697(+) TCCCAC/ACTGGG 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1920812761,2
    --1246727(+) GCCCCA/TTTCAT 1 -- us2k10--------
    rs1165820821,2
    F--1246747(+) CCCTCC/TTCCCT 1 -- us2k11Minor allele frequency- T:0.02WA 118
    rs1113567971,2
    C,F--1246756(+) CTCCAG/ACTGGG 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs734946491,2
    C,F--1246763(+) TGGGTC/ACAGTT 1 -- us2k12Minor allele frequency- A:0.27WA 120

    HapMap Linkage Disequilibrium report for MIDN (1248552 - 1259142 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for MIDN (see all 31):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv3589n71CNV Loss21882294
    nsv910469CNV Loss21882294
    dgv3590n71CNV Loss21882294
    dgv3586n71CNV Loss21882294
    nsv910292CNV Loss21882294
    nsv910471CNV Loss21882294
    dgv3591n71CNV Loss21882294
    dgv3595n71CNV Loss21882294
    dgv3555n71CNV Loss21882294
    nsv828371CNV Loss20364138

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MIDN
    DNA2.0 Custom Variant and Variant Library Synthesis for MIDN

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606700    OMIM disorders: --

    1 disease for MIDN:    About MalaCards
    peutz-jeghers syndrome

    1 disease from the University of Copenhagen DISEASES database for MIDN:
    Peutz-Jeghers syndrome

    MIDN for disorders           About GeneDecksing

    Genetic Association Database (GAD): MIDN

    Export disorders for MIDN gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MIDN gene, integrated from 10 sources (see all 12):
    (articles sorted by number of sources associating them with MIDN)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Novel nucleolar protein, midnolin, is expressed in the mesencephalon during mouse development. (PubMed id 10974535)1, 3 Tsukahara M....Tsunoo H. (Gene 2000)
    2. Identification of the ubiquitin-like domain of midnolin as a new glucokinase interaction partner. (PubMed id 24187134)1 Hofmeister-Brix A....Baltrusch S. (J. Biol. Chem. 2013)
    3. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    4. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    5. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    6. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)
    7. A directed protein interaction network for investigating intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (Sci Signal 2011)
    8. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (EMBO J. 2009)
    9. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1 Otsuki T....Isogai T. (DNA Res. 2005)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 90007 HGNC: 16298 AceView: MIDN Ensembl:ENSG00000167470 euGenes: HUgn90007
    ECgene: MIDN H-InvDB: MIDN

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MIDN Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MIDN gene:
    Search GeneIP for patents involving MIDN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     OriGene Antibodies for MIDN   OriGene RNAi products in human, mouse, rat for MIDN  
     OriGene qPCR primer pairs and template standards for MIDN   OriGene Protein Over-expression Lysate for MIDN  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for MIDN  
     OriGene qSTAR qPCR primer pairs in human, mouse for MIDN   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for MIDN   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for MIDN   OriGene Custom Protein Services for MIDN  

     
     
     Block miRNA regulation of human, mouse, rat MIDN using miScript Target Protectors SeqTarget long-range PCR primers for resequencing MIDN
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MIDN Predesigned siRNA for gene silencing in human, mouse, rat MIDN
     QuantiFast Probe-based Assays in human, mouse, rat MIDN QuantiTect SYBR Green Assays in human, mouse, rat MIDN
     Custom PCR Arrays for MIDN Search Chromatin IP Primers for MIDN
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MIDN  Search GeneGlobe Interaction Network for MIDN
     Regulatory tfbs in MIDN promoter
     GenScript Custom Purified and Recombinant Proteins Services for MIDN GenScript cDNA clones with any tag delivered in your preferred vector for MIDN
     GenScript Custom Assay Services for MIDN GenScript Custom overexpressing Cell Line Services for MIDN
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     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
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     Search Tocris compounds for MIDN
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     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
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     See all of Abcam's Antibodies, Kits and Proteins for MIDN
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     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for MIDN
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     CLIAs for MIDN



     Browse ESI BIO Cell Lines and PureStem Progenitors for MIDN
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MIDN
     SwitchGear 3'UTR luciferase reporter plasmids for MIDN
     SwitchGear Promoter luciferase reporter plasmids for MIDN
     Search ThermoFisher Antibodies for MIDN
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MIDN
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MIDN
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MIDN
     Search LSBio for Antibodies for MIDN
    Customized transgenic rodents for:
     Humanization
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     Translational medicine
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     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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