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MID2 Gene

protein-coding   GIFtS: 55
GCID: GC0XP107068

Midline 2

  See MID2-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Midline 21 2     midin-22
Midline Defect 22 3     midline-22
Tripartite Motif-Containing Protein 12 3     Probable E3 Ubiquitin-Protein Ligase MID22
FXY22 3     Tripartite Motif Protein 12
RNF602 3     EC 6.3.2.-3
TRIM12 3     Midin-23
RING Finger Protein 602 3     Midline-23
Midin 22     

External Ids:    HGNC: 70961   Entrez Gene: 110432   Ensembl: ENSG000000805617   OMIM: 3002045   UniProtKB: Q9UJV33   

Export aliases for MID2 gene to outside databases

Previous GC identifers: GC0XP102390 GC0XP103988 GC0XP105102 GC0XP105841 GC0XP106875 GC0XP106955 GC0XP096692


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MID2 Gene:
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three
zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes
to microtubular structures in the cytoplasm. Alternate splicing of this gene results in two transcript variants
encoding different isoforms. (provided by RefSeq, Feb 2009)

GeneCards Summary for MID2 Gene:
MID2 (midline 2) is a protein-coding gene. Diseases associated with MID2 include mental retardation, x-linked 17/31, microduplication. GO annotations related to this gene include ligase activity. An important paralog of this gene is TRIM13.

Gene Wiki entry for MID2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NT_011651.18  NC_018934.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MID2 gene promoter:
         Spz1   RFX1   AML1a   Nkx6-1   FOXO4   SEF-1 (1)   HNF-4alpha2   LCR-F1   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMID2 promoter sequence
   Search Chromatin IP Primers for MID2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MID2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq22.3   Ensembl cytogenetic band:  Xq22.3   HGNC cytogenetic band: Xq22.1-q22.2

MID2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MID2 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP107068:  view genomic region     (about GC identifiers)

Start:
107,068,985 bp from pter      End:
107,174,867 bp from pter
Size:
105,883 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TRIM1_HUMAN, Q9UJV3 (See protein sequence)
Recommended Name: Probable E3 ubiquitin-protein ligase MID2  
Size: 735 amino acids; 83210 Da
Subunit: Homodimer or heterodimer with MID1. Interacts with IGBP1
Caution: It is uncertain whether Met-1 or Met-21 is the initiator
Sequence caution: Sequence=AAF07341.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAH17707.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAB56154.1;
Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAI42073.1; Type=Erroneous gene model
prediction; Sequence=CAO72053.1; Type=Erroneous gene model prediction;
2 PDB 3D structures from and Proteopedia for MID2:
2DJA (3D)        2DMK (3D)    
Secondary accessions: A6NEL8 A6PVI5 Q5JYF5 Q8WWK1 Q9UJR9
Alternative splicing: 2 isoforms:  Q9UJV3-1   Q9UJV3-2   

Explore the universe of human proteins at neXtProt for MID2: NX_Q9UJV3

Explore proteomics data for MID2 at MOPED

Post-translational modifications: 

  • Phosphorylated on serine and threonine residues1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MID2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_036348.2  NP_438112.2  

    ENSEMBL proteins: 
     ENSP00000410730   ENSP00000262843   ENSP00000413976  

    MID2 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for MID2

     
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    MID2 Assay Products:

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    Search eBioscience for ELISAs for MID2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    FN3: Fibronectin type III domain containing
    TRIM: Tripartite motif containing / Tripartite motif containing
    RNF: RING-type (C3HC4) zinc fingers

    Selected InterPro protein domains (see all 14):
     IPR001841 Znf_RING
     IPR001870 B30.2/SPRY
     IPR017903 COS_domain
     IPR003961 Fibronectin_type3
     IPR027727 MID1/MID2

    Graphical View of Domain Structure for InterPro Entry Q9UJV3

    ProtoNet protein and cluster: Q9UJV3

    4 Blocks protein domains:
    IPB000315 B-box zinc finger signature
    IPB001841 Zn-finger
    IPB003649 B-box
    IPB003879 Butyrophylin C-terminal DUF signature


    UniProtKB/Swiss-Prot: TRIM1_HUMAN, Q9UJV3
    Domain: The tripartite motif (RBCC; RING- and B box-type zinc fingers and coiled coil domains) mediates
    dimerization (By similarity)
    Domain: Associates with microtubules in a manner that is dependent on the C-terminal B30.2 domain
    Similarity: Belongs to the TRIM/RBCC family
    Similarity: Contains 2 B box-type zinc fingers
    Similarity: Contains 1 B30.2/SPRY domain
    Similarity: Contains 1 COS domain
    Similarity: Contains 1 fibronectin type-III domain
    Similarity: Contains 1 RING-type zinc finger


    Find genes that share domains with MID2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:
         Genatlas biochemistry entry for MID2:
    midline 2,highly homolog to MID1,expressed in fetal tissues noteworthy in developing heart,confined to the
    cytoplasm in association to microtubule structures

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ----
    GO:0005515protein binding ----
    GO:0008017microtubule binding IMP11806752
    GO:0008270zinc ion binding IEA--
    GO:0016874ligase activity IEA--
         
    Find genes that share ontologies with MID2           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for MID2:
     Decreased cilium length after   Increased cell death HMECs cel 

         1 MGI phenotypic allele for Mid2 (no phenotypes)

    Find genes that share phenotypes with MID2           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MID2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MID2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MID2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MID2

    miRNA
    Products:
        
    miRTarBase miRNAs that target MID2:
    hsa-mir-128-3p (MIRT021934), hsa-mir-324-5p (MIRT043130)

    Block miRNA regulation of human, mouse, rat MID2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MID2 (see all 81):
    hsa-miR-411* hsa-miR-140-5p hsa-miR-3678-3p hsa-miR-607 hsa-miR-300 hsa-miR-485-3p hsa-miR-30d hsa-miR-374a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for MID2
    Predesigned siRNA for gene silencing in human, mouse, rat MID2

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for MID2 (see all 20)
    OriGene ORF clones in mouse, rat for MID2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): MID2 (NM_052817)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MID2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MID2
    Addgene plasmids for MID2 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MID2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TRIM1_HUMAN, Q9UJV3: Cytoplasm. Cytoplasm, cytoskeleton. Note=Microtubule-associated
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol3
    nucleus3
    endoplasmic reticulum1
    plasma membrane1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005737cytoplasm IEA--
    GO:0005813centrosome ----
    GO:0005874colocalizes with microtubule IDA10400986
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with MID2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    UniProtKB/Swiss-Prot: TRIM1_HUMAN, Q9UJV3
    Pathway: Protein modification; protein ubiquitination

        Pathway & Disease-focused RT2 Profiler PCR Array including MID2: 

              Ubiquitin Ligases in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for MID2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    Selected Interacting proteins for MID2 (Q9UJV32, 3 ENSP000002628434) via UniProtKB, MINT, STRING, and/or I2D (see all 27)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DYDC1Q8WWB32, 3, ENSP000003612764MINT-68349 I2D: score=4 STRING: ENSP00000361276
    GFI1BQ5VTD92, 3, ENSP000003447824MINT-2869152 I2D: score=3 STRING: ENSP00000344782
    IGBP1P783183, ENSP000003487844I2D: score=2 STRING: ENSP00000348784
    TRIM29Q141343, ENSP000003431294I2D: score=2 STRING: ENSP00000343129
    UBE2NP610883, ENSP000003161764I2D: score=1 STRING: ENSP00000316176
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ----
    GO:0016567protein ubiquitination IEA--
    GO:0032897negative regulation of viral transcription IDA18248090
    GO:0035372protein localization to microtubule IMP11806752
    GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling IDA--

    Find genes that share ontologies with MID2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MID2 (TRIM1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MID2 gene (2 alternative transcripts): 
    NM_012216.3  NM_052817.2  

    Unigene Cluster for MID2:

    Midline 2
    Hs.12256  [show with all ESTs]
    Unigene Representative Sequence: NM_012216
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000451923 ENST00000262843(uc004enk.3 uc004enl.3) ENST00000443968
    ENST00000474517
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MID2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MID2 (see all 81):
    hsa-miR-411* hsa-miR-140-5p hsa-miR-3678-3p hsa-miR-607 hsa-miR-300 hsa-miR-485-3p hsa-miR-30d hsa-miR-374a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for MID2
    Predesigned siRNA for gene silencing in human, mouse, rat MID2
    Clone
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    OriGene ORF clones in mouse, rat for MID2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): MID2 (NM_052817)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MID2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MID2
    Addgene plasmids for MID2 
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    Products:
        
    OriGene qPCR primer pairs and template standards for MID2
    OriGene qSTAR qPCR primer pairs in human, mouse for MID2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MID2
      QuantiTect SYBR Green Assays in human, mouse, rat MID2
      QuantiFast Probe-based Assays in human, mouse, rat MID2

    Additional mRNA sequence: 

    AF196481.1 AK095034.1 AK123807.1 AY625004.1 BC017707.1 BC035557.1 BC058011.1 BC070370.1 
    BT006663.1 Y18880.1 

    3 DOTS entries:

    DT.412574  DT.70105135  DT.65287194 

    Selected AceView cDNA sequences (see all 104):

    BC017707 NM_012216 AY625004 AI686504 AA592997 AI761689 BG163319 AI399929 
    BE747944 CB155145 AF196481 AK123807 AI339033 BG778541 AK095034 CA446387 
    BQ614138 BT006663 AI651246 AW195702 NM_052817 AA295489 F10511 AI638688 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for MID2    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9
    SP1:                                      -                     
    SP2:                                                            


    ECgene alternative splicing isoforms for MID2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MID2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGTCTTCTCT
    MID2 Expression
    About this image


    MID2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
     
     Thymus (Hematopoietic System)
             Thymus
     
     Peripheral Nervous System (Nervous System)
             Schwann Precursor Cells Peripheral Nerve Domain
     
     Kidney (Urinary System)
             Metanephros
    MID2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MID2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.12256

    UniProtKB/Swiss-Prot: TRIM1_HUMAN, Q9UJV3
    Tissue specificity: Low level in fetal kidney and lung, and in adult prostate, ovary and small intestine

        Pathway & Disease-focused RT2 Profiler PCR Array including MID2: 
              Ubiquitin Ligases in human mouse rat

    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for MID2
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    QuantiTect SYBR Green Assays in human, mouse, rat MID2
    QuantiFast Probe-based Assays in human, mouse, rat MID2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MID2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for MID2 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mid21 , 5 midline 21, 5 94.01(n)1
    99.27(a)1
      X (61.35 cM)5
    239471  NM_011845.21  NP_035975.11 
     1406645995 
    chicken
    (Gallus gallus)
    Aves MID21 midline 2 81.27(n)
    93.14(a)
      422131  XM_004940585.1  XP_004940642.1 
    lizard
    (Anolis carolinensis)
    Reptilia MID26
    midline 2
    88(a)
    1 ↔ 1
    GL343603.1(217699-300138)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004976461 probable E3 ubiquitin-protein ligase MID2-like 75.54(n)
    83.63(a)
      100497646  XM_002936777.2  XP_002936823.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mid26
    MID2 (2 of 2)6
    midline 2
    83(a)
    72(a)
    1 ↔ many
    1 ↔ many
    14(29360509-29410644) ENSDARG00000034871
    14(29178509-29223692) ENSDARG00000086722


    ENSEMBL Gene Tree for MID2 (if available)
    TreeFam Gene Tree for MID2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MID2 gene
    TRIM132  FSD1L2  TRIM462  TRIM632  TRIM592  TRIM92  TRIM672  TRIM362  
    TRIM552  MID12  TRIM542  FSD12  
    2 SIMAP similar genes for MID2 using alignment to 2 protein entries:     TRIM1_HUMAN (see all proteins):
    MID1    TRIM39

    Find genes that share paralogs with MID2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MID2 (see all 1238)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1815881421,2
    --107038857(+) TATATA/GCCATA 2 -- us2k10--------
    rs732498801,2
    C--107038969(+) GTTTTC/TTATTT 2 -- us2k10--------
    rs1908672041,2
    --107038978(+) TTGCTC/TGGATA 2 -- us2k10--------
    rs78803891,2
    C--107039047(+) aacctG/Ccatac 2 -- us2k14Minor allele frequency- C:0.20NA WA CSA 5
    rs1809938721,2
    --107039184(+) TTTTTA/GTAGAG 2 -- us2k10--------
    rs78806721,2
    C,A--107039260(+) agcatT/Cccctc 2 -- us2k13Minor allele frequency- C:0.25NA WA CSA 4
    rs1860702621,2
    --107039267(+) CCTCCC/TGAGTA 2 -- us2k10--------
    rs1121098091,2
    C,F--107039679(+) GTCCCT/ATTTAC 2 -- us2k11Minor allele frequency- A:0.00CSA 1
    rs1909712961,2
    --107039717(+) TAAGTA/GTGACT 2 -- us2k10--------
    rs593230421,2
    C,F--107039922(+) GAGGCA/GTGTGT 2 -- us2k12Minor allele frequency- G:0.25WA 4

    HapMap Linkage Disequilibrium report for MID2 (107068985 - 107174867 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for MID2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv508789CNV Insertion20534489

    Locus Specific Mutation Databases (LSDB): MID2

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MID2
    DNA2.0 Custom Variant and Variant Library Synthesis for MID2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300204    OMIM disorders: --

    1 disease for MID2:    
    About MalaCards
    mental retardation, x-linked 17/31, microduplication


    Find genes that share disorders with MID2           About GenesLikeMe

    2 Novoseek inferred disease relationships for MID2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hypospadias 78.7 2 18074389 (1), 18697196 (1)
    developmental disabilities 49.1 2 10400986 (1), 11806752 (1)

    Genetic Association Database (GAD): MID2

    Export disorders for MID2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MID2 gene, integrated from 10 sources (see all 31):
    (articles sorted by number of sources associating them with MID2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. MID2, a homologue of the Opitz syndrome gene MID1: similarities in a sub-cellular localization and differences in expression during development. (PubMed id 10400986)1, 2, 3, 9 Buchner G.... Franco B. (Hum. Mol. Genet. 1999)
    2. MID1 and MID2 homo- and heterodimerise to tether the rapamycin- sensitive PP2A regulatory subunit, Alpha 4, to microtubules: implications for the clinical variability of X-linked Opitz GBBB syndrome and other developmental disorders. (PubMed id 11806752)1, 2, 9 Short K.M.... Cox T.C. (BMC Cell Biol. 2002)
    3. FXY2/MID2, a gene related to the X-linked Opitz syndrome gene FXY/MID1, maps to Xq22 and encodes a FNIII domain-containing protein that associates with microtubules. (PubMed id 10644436)1, 2, 9 Perry J.... Ashworth A. (Genomics 1999)
    4. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (Nature 2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Subclassification of the RBCC/TRIM superfamily reveals a novel motif necessary for microtubule binding. (PubMed id 16434393)1, 9 Short K.M. and Cox T.C. (J. Biol. Chem. 2006)
    7. Association of connexin43 with E3 ubiquitin ligase TRIM21 reveals a mechanism for gap junction phosphodegron control. (PubMed id 23106098)1 Chen V.C....Naus C.C. (J. Proteome Res. 2012)
    8. Functional interactions between ubiquitin E2 enzymes and TRIM proteins. (PubMed id 21143188)1 Napolitano L.M....Meroni G. (Biochem. J. 2011)
    9. Large-scale proteomics and phosphoproteomics of urinary exosomes. (PubMed id 19056867)1 Gonzales P.A....Knepper M.A. (J. Am. Soc. Nephrol. 2009)
    10. A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system. (PubMed id 19690564)1 van Wijk S.J....Timmers H.T. (Mol. Syst. Biol. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 11043 HGNC: 7096 AceView: MID2 Ensembl:ENSG00000080561 euGenes: HUgn11043
    ECgene: MID2 H-InvDB: MID2

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for MID2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for MID2 gene:
    Search GeneIP for patents involving MID2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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