MID2 Gene

Aliases
for MID2 gene

Previous GC identifers: GC0XP102390 GC0XP103988 GC0XP105102 GC0XP105841 GC0XP106875 GC0XP106955 GC0XP096692

Summaries
for MID2 gene

Genomic Views
for MID2 gene

RefSeq DNA sequence:

NC_000023.10  NC_018934.1  NT_011651.17  

SwitchGear Promoter luciferase reporter plasmid: MID2 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MID2

MID2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP107068:  view genomic region     (about GC identifiers)

Proteins
for MID2 gene

2 PDB 3D structures from and Proteopedia for MID2:

2DJA (3D)        2DMK (3D)    

Explore the universe of human proteins at neXtProt for MID2: NX_Q9UJV3

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: MID2 OriGene Protein Over-expression Lysate (see all 2): MID2 OriGene Custom Protein Services for MID2
	GenScript Custom Purified and Recombinant Proteins Services for MID2
	Novus Biologicals MID2 Proteins Novus Biologicals MID2 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for MID2

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	OriGene Antibodies: MID2 OriGene Custom Antibody Services for MID2
	GenScript Custom Superior Antibodies Services for MID2
	Novus Biologicals MID2 Antibodies
	Search for Antibodies for MID2 at Abcam
	Uscn Antibodies for MID2
	ThermoFisher Antibodies for MID2

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for MID2
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for MID2

Protein Domains /
Families
for MID2 gene

ProtoNet protein and cluster: Q9UJV3

Function
for MID2 gene

miRNA Products:		OriGene 3'-UTR Clone (see all 2): MID2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MID2
		8/81 QIAGEN miScript miRNA Assays for microRNAs that regulate MID2 (see all 81):
		hsa-miR-411* hsa-miR-140-5p hsa-miR-3678-3p hsa-miR-607 hsa-miR-300 hsa-miR-485-3p hsa-miR-30d hsa-miR-374a
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MID2 (see all 4) OriGene shRNA RFP: MID2 OriGene siRNA: MID2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MID2

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for MID2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MID2 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MID2 (see all 5) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): MID2 (NM_052817)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MID2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MID2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for MID2
		Search LifeMap BioReagents cell lines for MID2

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MID2

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

Pathways & Interactions
for MID2 gene

Interactions:

    SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for MID2

STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

5/25 Interacting proteins for MID2 (Q9UJV3^{2, 3} ENSP00000262843⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 25)

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

Drugs & Compounds
for MID2 gene

Transcripts
for MID2 gene

Expression
for MID2 gene

MID2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGTCTTCTCT

Stem Cell Differentiation: 1 LifeMap Cell
	Name			Category
	PureStem™ progenitor EN2 (Embryonic Progenitor Cell)
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MID2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MID2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MID2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MID2

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MID2

Orthologs
for MID2 gene

Paralogs
for MID2 gene

Paralogs for MID2 gene

TRIM13²  FSD1L²  TRIM46²  TRIM63²  TRIM59²  TRIM67²  TRIM9²  TRIM36²  

MID1²  TRIM55²  TRIM54²  FSD1²  

3 SIMAP similar genes for MID2 using alignment to 2 protein entries:     TRIM1_HUMAN (see all proteins):

MID1    TRIM39    TRIM36

MID2 for paralogs           About GeneDecksing

Genomic Variants
for MID2 gene

10/1021 NCBI SNPs in MID2 are shown (see all 1021)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr X pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1815881421,2		--	107067141(+)	TATATA/GCCATA	2	--	us2k1		0	--	--	--	--
rs732498801,2	C,	--	107067253(+)	GTTTTC/TTATTT	2	--	us2k1		0	--	--	--	--
rs1908672041,2		--	107067262(+)	TTGCTC/TGGATA	2	--	us2k1		0	--	--	--	--
rs78803891,2	C,	--	107067331(+)	AACCTG/CCATAC	2	--	us2k1		4		NA WA CSA	5
rs1809938721,2		--	107067468(+)	TTTTTA/GTAGAG	2	--	us2k1		0	--	--	--	--
rs78806721,2	C,A,	--	107067544(+)	AGCATT/CCCCTC	2	--	us2k1		3		NA WA CSA	4
rs1860702621,2		--	107067551(+)	CCTCCC/TGAGTA	2	--	us2k1		0	--	--	--	--
rs1121098091,2	C,	--	107067963(+)	GTCCCT/ATTTAC	2	--	us2k1		1		CSA	1
rs1909712961,2		--	107068001(+)	TAAGTA/GTGACT	2	--	us2k1		0	--	--	--	--
rs593230421,2	C,	--	107068206(+)	GAGGCA/GTGTGT	2	--	us2k1		2		WA	4

HapMap Linkage Disequilibrium report for MID2 (107068985 - 107174867 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for MID2: --
Locus Specific Mutation Databases (LSDB): MID2

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MID2

DNA2.0 Custom Variant and Variant Library Synthesis for MID2

Disorders / Diseases
for MID2 gene

8 diseases for MID2

2 Novoseek disease relationships for MID2 gene    About this table

Publications
for MID2 gene

PubMed articles for MID2 gene, integrated from 9 sources (see all 27): (articles sorted by number of sources associating them with MID2)

Utopia: connect your pdf to the dynamic world of online information

1. MID2, a homologue of the Opitz syndrome gene MID1: similarities in a sub-cellular localization and differences in expression during development. (PubMed id 10400986)^{1, 2, 3, 9} Buchner G.... Franco B. (1999)
2. MID1 and MID2 homo- and heterodimerise to tether the rapamycin- sensitive PP2A regulatory subunit, Alpha 4, to microtubules: implications for the clinical variability of X-linked Opitz GBBB syndrome and other developmental disorders. (PubMed id 11806752)^{1, 2, 9} Short K.M.... Cox T.C. (2002)
3. FXY2/MID2, a gene related to the X-linked Opitz syndrome gene FXY/MID1, maps to Xq22 and encodes a FNIII domain-containing protein that associates with microtubules. (PubMed id 10644436)^{1, 2, 9} Perry J.... Ashworth A. (1999)
4. The DNA sequence of the human X chromosome. (PubMed id 15772651)^{1, 2} Ross M.T.... Bentley D.R. (2005)
5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
6. Subclassification of the RBCC/TRIM superfamily reveals a novel motif necessary for microtubule binding. (PubMed id 16434393)^{1, 9} Short K.M. and Cox T.C. (2006)
7. Functional interactions between ubiquitin E2 enzymes a nd TRIM proteins. (PubMed id 21143188)¹ Napolitano L.M....Meroni G. (2011)
8. A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system. (PubMed id 19690564)¹ van Wijk S.J....Timmers H.T. (2009)
9. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)¹ Barbe L....Andersson-Svahn H. (2008)
10. A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PubMed id 16713569)¹ Lim J.... Zoghbi H.Y. (2006)

External Searches for MID2 gene

Genome Databases showing MID2 gene

Other Databases showing MID2 gene

Specialized Databases showing MID2 gene

Products
for MID2 gene