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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MID2 Gene

protein-coding   GIFtS: 55
GCID: GC0XP107068

Midline 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Midline 21 2     midin-22
Midline Defect 22 3     midline-22
Tripartite Motif-Containing Protein 12 3     Probable E3 Ubiquitin-Protein Ligase MID22
FXY22 3     Tripartite Motif Protein 12
RNF602 3     EC 6.3.2.-3
TRIM12 3     Midin-23
RING Finger Protein 602 3     Midline-23
Midin 22     

External Ids:    HGNC: 70961   Entrez Gene: 110432   Ensembl: ENSG000000805617   OMIM: 3002045   UniProtKB: Q9UJV33   

Export aliases for MID2 gene to outside databases

Previous GC identifers: GC0XP102390 GC0XP103988 GC0XP105102 GC0XP105841 GC0XP106875 GC0XP106955 GC0XP096692


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MID2 Gene:
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three
zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes
to microtubular structures in the cytoplasm. Alternate splicing of this gene results in two transcript variants
encoding different isoforms. (provided by RefSeq, Feb 2009)

GeneCards Summary for MID2 Gene: 
MID2 (midline 2) is a protein-coding gene. Diseases associated with MID2 include opitz g/bbb syndrome, and fg syndrome. GO annotations related to this gene include molecular_function and ligase activity. An important paralog of this gene is TRIM13.

Gene Wiki entry for MID2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NT_011651.17  NC_018934.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MID2 gene promoter:
         Spz1   RFX1   AML1a   Nkx6-1   FOXO4   SEF-1 (1)   HNF-4alpha2   LCR-F1   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMID2 promoter sequence
   Search SABiosciences Chromatin IP Primers for MID2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MID2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq22.3   Ensembl cytogenetic band:  Xq22.3   HGNC cytogenetic band: Xq22.1-q22.2

MID2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MID2 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP107068:  view genomic region     (about GC identifiers)

Start:
107,068,985 bp from pter      End:
107,174,867 bp from pter
Size:
105,883 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TRIM1_HUMAN, Q9UJV3 (See protein sequence)
Recommended Name: Probable E3 ubiquitin-protein ligase MID2  
Size: 735 amino acids; 83210 Da
Subunit: Homodimer or heterodimer with MID1. Interacts with IGBP1
Subcellular location: Cytoplasm. Cytoplasm, cytoskeleton. Note=Microtubule-associated
Caution: It is uncertain whether Met-1 or Met-21 is the initiator
Sequence caution: Sequence=AAF07341.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAH17707.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAB56154.1;
Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAI42073.1; Type=Erroneous gene model
prediction; Sequence=CAO72053.1; Type=Erroneous gene model prediction;
2 PDB 3D structures from and Proteopedia for MID2:
2DJA (3D)        2DMK (3D)    
Secondary accessions: A6NEL8 A6PVI5 Q5JYF5 Q8WWK1 Q9UJR9
Alternative splicing: 2 isoforms:  Q9UJV3-1   Q9UJV3-2   

Explore the universe of human proteins at neXtProt for MID2: NX_Q9UJV3

Explore proteomics data for MID2 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated on serine and threonine residues
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UJV3

  • MID2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MID2 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_036348.2  NP_438112.2  

    ENSEMBL proteins: 
     ENSP00000410730   ENSP00000262843   ENSP00000413976  

    Human Recombinant Protein Products for MID2: 
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    Novus Biologicals MID2 Proteins
    Novus Biologicals MID2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MID2 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005737cytoplasm IDA--
    GO:0005813centrosome IDA--
    GO:0005874colocalizes with microtubule IDA10400986

    MID2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    FN3: Fibronectin type III domain containing
    TRIM: Tripartite motif containing / Tripartite motif containing
    RNF: RING-type (C3HC4) zinc fingers

    5/13 InterPro protein domains (see all 13):
     IPR001841 Znf_RING
     IPR001870 B30.2/SPRY
     IPR017903 COS_domain
     IPR003961 Fibronectin_type3
     IPR013783 Ig-like_fold

    Graphical View of Domain Structure for InterPro Entry Q9UJV3

    ProtoNet protein and cluster: Q9UJV3

    4 Blocks protein domains:
    IPB000315 B-box zinc finger signature
    IPB001841 Zn-finger
    IPB003649 B-box
    IPB003879 Butyrophylin C-terminal DUF signature


    UniProtKB/Swiss-Prot: TRIM1_HUMAN, Q9UJV3
    Domain: The tripartite motif (RBCC; RING- and B box-type zinc fingers and coiled coil domains) mediates
    dimerization (By similarity)
    Domain: Associates with microtubules in a manner that is dependent on the C-terminal B30.2 domain
    Similarity: Belongs to the TRIM/RBCC family
    Similarity: Contains 2 B box-type zinc fingers
    Similarity: Contains 1 B30.2/SPRY domain
    Similarity: Contains 1 COS domain
    Similarity: Contains 1 fibronectin type-III domain
    Similarity: Contains 1 RING-type zinc finger


    MID2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:
         Genatlas biochemistry entry for MID2:
    midline 2,highly homolog to MID1,expressed in fetal tissues noteworthy in developing heart,confined to the
    cytoplasm in association to microtubule structures

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
    GO:0016874ligase activity IEA--
    GO:0046872metal ion binding ----
         
    MID2 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for MID2:
     Decreased cilium length after   Increased cell death HMECs cel 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for MID2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MID2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MID2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MID2 

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    8/81 QIAGEN miScript miRNA Assays for microRNAs that regulate MID2 (see all 81):
    hsa-miR-411* hsa-miR-140-5p hsa-miR-3678-3p hsa-miR-607 hsa-miR-300 hsa-miR-485-3p hsa-miR-30d hsa-miR-374a
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MID2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    UniProtKB/Swiss-Prot: TRIM1_HUMAN, Q9UJV3
    Pathway: Protein modification; protein ubiquitination

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MID2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    5/25 Interacting proteins for MID2 (Q9UJV32, 3 ENSP000002628434) via UniProtKB, MINT, STRING, and/or I2D (see all 25)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    DYDC1Q8WWB32, 3, ENSP000003612764MINT-68349 I2D: score=4 STRING: ENSP00000361276
    GFI1BQ5VTD92, 3, ENSP000003447824MINT-2869152 I2D: score=3 STRING: ENSP00000344782
    IGBP1P783183, ENSP000003487844I2D: score=2 STRING: ENSP00000348784
    TRIM29Q141343, ENSP000003431294I2D: score=2 STRING: ENSP00000343129
    UBE2NP610883, ENSP000003161764I2D: score=1 STRING: ENSP00000316176
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--
    GO:0016567protein ubiquitination IEA--

    MID2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MID2 (TRIM1)

    Search CenterWatch for drugs/clinical trials and news about MID2 / TRIM1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MID2 gene (2 alternative transcripts): 
    NM_012216.3  NM_052817.2  

    Unigene Cluster for MID2:

    Midline 2
    Hs.12256  [show with all ESTs]
    Unigene Representative Sequence: NM_012216
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000451923 ENST00000262843(uc004enk.3 uc004enl.3) ENST00000443968
    ENST00000474517
    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MID2
    8/81 QIAGEN miScript miRNA Assays for microRNAs that regulate MID2 (see all 81):
    hsa-miR-411* hsa-miR-140-5p hsa-miR-3678-3p hsa-miR-607 hsa-miR-300 hsa-miR-485-3p hsa-miR-30d hsa-miR-374a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MID2
    Sirion Biotech Customized lentivirus for stable overexpression of MID2 
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MID2

    Additional mRNA sequence: 

    AF196481.1 AK095034.1 AK123807.1 AY625004.1 BC017707.1 BC035557.1 BC058011.1 BC070370.1 
    BT006663.1 Y18880.1 

    3 DOTS entries:

    DT.412574  DT.70105135  DT.65287194 

    24/104 AceView cDNA sequences (see all 104):

    BC017707 BG163319 AY625004 AI399929 CB155145 AF196481 AK123807 AI339033 
    BG778541 AK095034 CA446387 BQ614138 BT006663 AI651246 AW195702 NM_052817 
    AA295489 F10511 AI638688 BC070370 Y18880 AI078183 BQ188085 BX119647 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for MID2    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9
    SP1:                                      -                     
    SP2:                                                            


    ECgene alternative splicing isoforms for MID2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MID2 expression in normal human tissues (normalized intensities)      MID2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGTCTTCTCT
    MID2 Expression
    About this image


    MID2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/14 selected tissues (see all 14) fully expand
     
     Brain (Nervous System)    fully expand to see all 7 entries
             Cerebral Cortex
             ganglion/cranial   
     
     Heart (Cardiovascular System)    fully expand to see all 3 entries
             heart/ventricle   
     
     Nose (Sensory Organs)    fully expand to see all 2 entries
             sensory organ/nose/nasal cavity   
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
     
     Peripheral Nervous System (Nervous System)
             Schwann Precursor Cells Peripheral Nerve Domain

    See MID2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MID2

    SOURCE GeneReport for Unigene cluster: Hs.12256

    UniProtKB/Swiss-Prot: TRIM1_HUMAN, Q9UJV3
    Tissue specificity: Low level in fetal kidney and lung, and in adult prostate, ovary and small intestine

        SABiosciences Expression via Pathway-Focused PCR Array including MID2: 
              Ubiquitin Ligases in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MID2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for MID2 gene from 4/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mid21 , 5 midline 21, 5 94.01(n)1
    99.27(a)1
      X (61.35 cM)5
    239471  NM_011845.21  NP_035975.11 
     1406645995 
    chicken
    (Gallus gallus)
    Aves MID21 midline 2 81.27(n)
    93.14(a)
      422131  XM_420134.3  XP_420134.3 
    lizard
    (Anolis carolinensis)
    Reptilia MID26
    MID26
    Uncharacterized protein
    88(a)
    87(a)
    1 ↔ 1
    possible ortholog
    GL343603.1(217699-300138)
    GL343451.1(722482-723156)
    zebrafish
    (Danio rerio)
    Actinopterygii mid26
    MID2 (2 of 2)6
    midline 2
    83(a)
    69(a)
    1 ↔ many
    1 ↔ many
    14(29360509-29410644)
    14(29178509-29223692)


    ENSEMBL Gene Tree for MID2 (if available)
    TreeFam Gene Tree for MID2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MID2 gene
    TRIM132  ENSG000002487102  FSD1L2  TRIM462  TRIM632  TRIM592  TRIM92  TRIM672  
    TRIM362  TRIM552  MID12  TRIM542  FSD12  
    2 SIMAP similar genes for MID2 using alignment to 2 protein entries:     TRIM1_HUMAN (see all proteins):
    MID1    TRIM39

    MID2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1238 SNPs in MID2 are shown (see all 1238)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1815881421,2
    --107038857(+) TATATA/GCCATA 2 -- us2k10--------
    rs732498801,2
    C--107038969(+) GTTTTC/TTATTT 2 -- us2k10--------
    rs1908672041,2
    --107038978(+) TTGCTC/TGGATA 2 -- us2k10--------
    rs78803891,2
    C--107039047(+) aacctG/Ccatac 2 -- us2k14Minor allele frequency- C:0.20NA WA CSA 5
    rs1809938721,2
    --107039184(+) TTTTTA/GTAGAG 2 -- us2k10--------
    rs78806721,2
    C,A--107039260(+) agcatT/Cccctc 2 -- us2k13Minor allele frequency- C:0.25NA WA CSA 4
    rs1860702621,2
    --107039267(+) CCTCCC/TGAGTA 2 -- us2k10--------
    rs1121098091,2
    C,F--107039679(+) GTCCCT/ATTTAC 2 -- us2k11Minor allele frequency- A:0.00CSA 1
    rs1909712961,2
    --107039717(+) TAAGTA/GTGACT 2 -- us2k10--------
    rs593230421,2
    C,F--107039922(+) GAGGCA/GTGTGT 2 -- us2k12Minor allele frequency- G:0.25WA 4

    HapMap Linkage Disequilibrium report for MID2 (107068985 - 107174867 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for MID2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv508789CNV Insertion20534489


    Locus Specific Mutation Databases (LSDB): MID2
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 300204    OMIM disorders: --

    7 diseases for MID2:    About MalaCards
    opitz g/bbb syndrome    fg syndrome    wolf-hirschhorn syndrome    developmental disabilities
    hypospadias    leukemia    prostatitis


    MID2 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for MID2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hypospadias 78.7 2 18074389 (1), 18697196 (1)
    developmental disabilities 49.1 2 10400986 (1), 11806752 (1)

    Genetic Association Database (GAD): MID2

    Export disorders for MID2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MID2 gene, integrated from 9 sources (see all 29):
    (articles sorted by number of sources associating them with MID2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. MID2, a homologue of the Opitz syndrome gene MID1: similarities in a sub-cellular localization and differences in expression during development. (PubMed id 10400986)1, 2, 3, 9 Buchner G.... Franco B. (1999)
    2. MID1 and MID2 homo- and heterodimerise to tether the rapamycin- sensitive PP2A regulatory subunit, Alpha 4, to microtubules: implications for the clinical variability of X-linked Opitz GBBB syndrome and other developmental disorders. (PubMed id 11806752)1, 2, 9 Short K.M.... Cox T.C. (2002)
    3. FXY2/MID2, a gene related to the X-linked Opitz syndrome gene FXY/MID1, maps to Xq22 and encodes a FNIII domain-containing protein that associates with microtubules. (PubMed id 10644436)1, 2, 9 Perry J.... Ashworth A. (1999)
    4. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Subclassification of the RBCC/TRIM superfamily reveals a novel motif necessary for microtubule binding. (PubMed id 16434393)1, 9 Short K.M. and Cox T.C. (2006)
    7. Association of connexin43 with E3 ubiquitin ligase TRI M21 reveals a mechanism for gap junction phosphodegron control. (PubMed id 23106098)1 Chen V.C....Naus C.C. (2012)
    8. Functional interactions between ubiquitin E2 enzymes a nd TRIM proteins. (PubMed id 21143188)1 Napolitano L.M....Meroni G. (2011)
    9. A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system. (PubMed id 19690564)1 van Wijk S.J....Timmers H.T. (2009)
    10. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 11043 HGNC: 7096 AceView: MID2 Ensembl:ENSG00000080561 euGenes: HUgn11043
    ECgene: MID2 H-InvDB: MID2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MID2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MID2 gene:
    Search GeneIP for patents involving MID2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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