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Aliases for MID1IP1 Gene

Aliases for MID1IP1 Gene

  • MID1 Interacting Protein 1 2 3 5
  • Spot 14-Related Protein 3 4
  • Spot 14-R 3 4
  • MIG12 3 4
  • S14R 3 4
  • MID1 Interacting Protein 1 (Gastrulation Specific G12-Like (Zebrafish)) 2
  • MID1 Interacting Protein 1 (Gastrulation Specific G12-Like) 3
  • Gastrulation Specific G12 Homolog (Zebrafish) 2
  • Gastrulation-Specific G12-Like Protein 4
  • MID1 Interacting G12-Like Protein 3
  • Gastrulation Specific G12 Homolog 3
  • Mid1-Interacting G12-Like Protein 4
  • Protein STRAIT11499 4
  • STRAIT11499 3
  • G12-Like 3
  • THRSPL 3

External Ids for MID1IP1 Gene

Previous GeneCards Identifiers for MID1IP1 Gene

  • GC0XP038416
  • GC0XP038545
  • GC0XP038660
  • GC0XP036404

Summaries for MID1IP1 Gene

GeneCards Summary for MID1IP1 Gene

MID1IP1 (MID1 Interacting Protein 1) is a Protein Coding gene. GO annotations related to this gene include protein C-terminus binding. An important paralog of this gene is THRSP.

UniProtKB/Swiss-Prot for MID1IP1 Gene

  • Plays a role in the regulation of lipogenesis in liver. Up-regulates ACACA enzyme activity. Required for efficient lipid biosynthesis, including triacylglycerol, diacylglycerol and phospholipid. Involved in stabilization of microtubules (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MID1IP1 Gene

Genomics for MID1IP1 Gene

Regulatory Elements for MID1IP1 Gene

Transcription factor binding sites by QIAGEN in the MID1IP1 gene promoter:

Genomic Location for MID1IP1 Gene

Chromosome:
X
Start:
38,801,432 bp from pter
End:
38,806,537 bp from pter
Size:
5,106 bases
Orientation:
Plus strand

Genomic View for MID1IP1 Gene

Genes around MID1IP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MID1IP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MID1IP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MID1IP1 Gene

Proteins for MID1IP1 Gene

  • Protein details for MID1IP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NPA3-M1IP1_HUMAN
    Recommended name:
    Mid1-interacting protein 1
    Protein Accession:
    Q9NPA3
    Secondary Accessions:
    • D3DWB2

    Protein attributes for MID1IP1 Gene

    Size:
    183 amino acids
    Molecular mass:
    20202 Da
    Quaternary structure:
    • Homodimer in the absence of THRSP. Heterodimer with THRSP. The homodimer interacts with ACACA and ACACB. Promotes polymerization of Acetyl-CoA carboxylase to form complexes that contain MID1IP1 and ACACA and/or ACACB. Interaction with THRSP interferes with ACACA binding (By similarity).
    SequenceCaution:
    • Sequence=DAA01482.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for MID1IP1 Gene

Proteomics data for MID1IP1 Gene at MOPED

Post-translational modifications for MID1IP1 Gene

  • Ubiquitination at Lys 11, Lys 124, and Lys 173
  • Modification sites at PhosphoSitePlus

Other Protein References for MID1IP1 Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for MID1IP1

No data available for DME Specific Peptides for MID1IP1 Gene

Domains & Families for MID1IP1 Gene

Protein Domains for MID1IP1 Gene

Suggested Antigen Peptide Sequences for MID1IP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NPA3

UniProtKB/Swiss-Prot:

M1IP1_HUMAN :
  • Belongs to the SPOT14 family.
Family:
  • Belongs to the SPOT14 family.
genes like me logo Genes that share domains with MID1IP1: view

No data available for Gene Families for MID1IP1 Gene

Function for MID1IP1 Gene

Molecular function for MID1IP1 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in the regulation of lipogenesis in liver. Up-regulates ACACA enzyme activity. Required for efficient lipid biosynthesis, including triacylglycerol, diacylglycerol and phospholipid. Involved in stabilization of microtubules (By similarity).
genes like me logo Genes that share phenotypes with MID1IP1: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MID1IP1 Gene

Localization for MID1IP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MID1IP1 Gene

Nucleus. Cytoplasm. Cytoplasm, cytoskeleton. Note=Associated with microtubules. {ECO:0000250 UniProtKB:Q9CQ20}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MID1IP1 Gene COMPARTMENTS Subcellular localization image for MID1IP1 gene
Compartment Confidence
cytosol 5
cytoskeleton 4
nucleus 4
extracellular 1
mitochondrion 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for MID1IP1 Gene

Pathways & Interactions for MID1IP1 Gene

SuperPathways for MID1IP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MID1IP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0007026 negative regulation of microtubule depolymerization IEA,ISS --
GO:0051258 protein polymerization IEA,ISS --
GO:0051351 positive regulation of ligase activity IEA,ISS --
genes like me logo Genes that share ontologies with MID1IP1: view

No data available for Pathways by source and SIGNOR curated interactions for MID1IP1 Gene

Drugs & Compounds for MID1IP1 Gene

No Compound Related Data Available

Transcripts for MID1IP1 Gene

Unigene Clusters for MID1IP1 Gene

MID1 interacting protein 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MID1IP1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c
SP1: -
SP2: - -
SP3:

Relevant External Links for MID1IP1 Gene

GeneLoc Exon Structure for
MID1IP1
ECgene alternative splicing isoforms for
MID1IP1

Expression for MID1IP1 Gene

mRNA expression in normal human tissues for MID1IP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MID1IP1 Gene

This gene is overexpressed in Fetal Liver (30.0), Esophagus (16.1), Testis (8.9), Pancreas (7.2), and Spinal cord (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MID1IP1 Gene



SOURCE GeneReport for Unigene cluster for MID1IP1 Gene Hs.522605

genes like me logo Genes that share expression patterns with MID1IP1: view

Protein tissue co-expression partners for MID1IP1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MID1IP1 Gene

Orthologs for MID1IP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MID1IP1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MID1IP1 35
  • 92.49 (n)
  • 93.96 (a)
MID1IP1 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MID1IP1 35
  • 92.71 (n)
  • 93.44 (a)
MID1IP1 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mid1ip1 35
  • 89.87 (n)
  • 90.06 (a)
Mid1ip1 16
Mid1ip1 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MID1IP1 35
  • 99.27 (n)
  • 98.91 (a)
MID1IP1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mid1ip1 35
  • 89.74 (n)
  • 90.11 (a)
oppossum
(Monodelphis domestica)
Mammalia MID1IP1 36
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves MID1IP1 35
  • 76.1 (n)
  • 73.58 (a)
lizard
(Anolis carolinensis)
Reptilia MID1IP1 36
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75801 35
mid1ip1 35
  • 67.33 (n)
  • 70.67 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.1604 35
zebrafish
(Danio rerio)
Actinopterygii g12 35
mid1ip1b 35
  • 64.84 (n)
  • 68.49 (a)
mid1ip1a 36
  • 52 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.423 35
Species with no ortholog for MID1IP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MID1IP1 Gene

ENSEMBL:
Gene Tree for MID1IP1 (if available)
TreeFam:
Gene Tree for MID1IP1 (if available)

Paralogs for MID1IP1 Gene

Paralogs for MID1IP1 Gene

(1) SIMAP similar genes for MID1IP1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MID1IP1: view

Variants for MID1IP1 Gene

Sequence variations from dbSNP and Humsavar for MID1IP1 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs9887 -- 38,806,285(-) TCCAC(A/T)TTCTC utr-variant-3-prime
rs1043814 -- 38,806,199(+) cccca(C/T)cccca utr-variant-3-prime
rs12832786 -- 38,806,389(+) ACTTT(C/T)TTTAA utr-variant-3-prime
rs41310601 -- 38,806,762(+) AGTGC(A/G)TAATT downstream-variant-500B
rs140773051 -- 38,806,972(+) TCACT(A/G)GTTCC downstream-variant-500B

Variation tolerance for MID1IP1 Gene

Residual Variation Intolerance Score: 33.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.49; 10.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MID1IP1 Gene

HapMap Linkage Disequilibrium report
MID1IP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MID1IP1 Gene

Disorders for MID1IP1 Gene

Relevant External Links for MID1IP1

Genetic Association Database (GAD)
MID1IP1
Human Genome Epidemiology (HuGE) Navigator
MID1IP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MID1IP1

No disorders were found for MID1IP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MID1IP1 Gene

Publications for MID1IP1 Gene

  1. Mig12, a novel Opitz syndrome gene product partner, is expressed in the embryonic ventral midline and co-operates with Mid1 to bundle and stabilize microtubules. (PMID: 15070402) Berti C. … Meroni G. (BMC Cell Biol. 2004) 3 4 23 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Interactome mapping suggests new mechanistic details underlying Alzheimer's disease. (PMID: 21163940) Soler-LA^pez M. … Aloy P. (Genome Res. 2011) 3
  5. A directed protein interaction network for investigating intracellular signal transduction. (PMID: 21900206) Vinayagam A. … Wanker E.E. (Sci Signal 2011) 3

Products for MID1IP1 Gene

Sources for MID1IP1 Gene

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