Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MID1IP1 Gene

Aliases for MID1IP1 Gene

  • MID1 Interacting Protein 1 2 3
  • Spot 14-Related Protein 3 4
  • Spot 14-R 3 4
  • MIG12 3 4
  • S14R 3 4
  • MID1 Interacting Protein 1 (Gastrulation Specific G12-Like (Zebrafish)) 2
  • MID1 Interacting Protein 1 (Gastrulation Specific G12-Like) 3
  • Gastrulation Specific G12 Homolog (Zebrafish) 2
  • Gastrulation-Specific G12-Like Protein 4
  • MID1 Interacting G12-Like Protein 3
  • Gastrulation Specific G12 Homolog 3
  • Mid1-Interacting G12-Like Protein 4
  • Mid1-Interacting Protein 1 3
  • Protein STRAIT11499 4
  • STRAIT11499 3
  • G12-Like 3
  • THRSPL 3

External Ids for MID1IP1 Gene

Previous GeneCards Identifiers for MID1IP1 Gene

  • GC0XP038416
  • GC0XP038545
  • GC0XP038660
  • GC0XP036404

Summaries for MID1IP1 Gene

GeneCards Summary for MID1IP1 Gene

MID1IP1 (MID1 Interacting Protein 1) is a Protein Coding gene. GO annotations related to this gene include protein C-terminus binding. An important paralog of this gene is THRSP.

UniProtKB/Swiss-Prot for MID1IP1 Gene

  • Plays a role in the regulation of lipogenesis in liver. Up-regulates ACACA enzyme activity. Required for efficient lipid biosynthesis, including triacylglycerol, diacylglycerol and phospholipid. Involved in stabilization of microtubules (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MID1IP1 Gene

Genomics for MID1IP1 Gene

Regulatory Elements for MID1IP1 Gene

Transcription factor binding sites by QIAGEN in the MID1IP1 gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MID1IP1 Gene

Start:
38,801,432 bp from pter
End:
38,806,537 bp from pter
Size:
5,106 bases
Orientation:
Plus strand

Genomic View for MID1IP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MID1IP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MID1IP1 Gene

Proteins for MID1IP1 Gene

  • Protein details for MID1IP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NPA3-M1IP1_HUMAN
    Recommended name:
    Mid1-interacting protein 1
    Protein Accession:
    Q9NPA3
    Secondary Accessions:
    • D3DWB2

    Protein attributes for MID1IP1 Gene

    Size:
    183 amino acids
    Molecular mass:
    20202 Da
    Quaternary structure:
    • Homodimer in the absence of THRSP. Heterodimer with THRSP. The homodimer interacts with ACACA and ACACB. Promotes polymerization of Acetyl-CoA carboxylase to form complexes that contain MID1IP1 and ACACA and/or ACACB. Interaction with THRSP interferes with ACACA binding (By similarity).
    SequenceCaution:
    • Sequence=DAA01482.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for MID1IP1 Gene

Proteomics data for MID1IP1 Gene at MOPED

Post-translational modifications for MID1IP1 Gene

  • Ubiquitination at Lys124 and Lys173
  • Modification sites at PhosphoSitePlus

Other Protein References for MID1IP1 Gene

No data available for DME Specific Peptides for MID1IP1 Gene

Domains for MID1IP1 Gene

Protein Domains for MID1IP1 Gene

Suggested Antigen Peptide Sequences for MID1IP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NPA3

UniProtKB/Swiss-Prot:

M1IP1_HUMAN :
  • Q9NPA3
Family:
  • Belongs to the SPOT14 family.
genes like me logo Genes that share domains with MID1IP1: view

No data available for Gene Families for MID1IP1 Gene

Function for MID1IP1 Gene

Molecular function for MID1IP1 Gene

UniProtKB/Swiss-Prot Function: Plays a role in the regulation of lipogenesis in liver. Up-regulates ACACA enzyme activity. Required for efficient lipid biosynthesis, including triacylglycerol, diacylglycerol and phospholipid. Involved in stabilization of microtubules (By similarity).

Gene Ontology (GO) - Molecular Function for MID1IP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0008022 protein C-terminus binding IEA --
genes like me logo Genes that share ontologies with MID1IP1: view

Phenotypes for MID1IP1 Gene

genes like me logo Genes that share phenotypes with MID1IP1: view

Animal Model Products

CRISPR Products

miRNA for MID1IP1 Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MID1IP1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for MID1IP1 Gene

Localization for MID1IP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MID1IP1 Gene

Nucleus. Cytoplasm. Cytoplasm, cytoskeleton. Note=Associated with microtubules. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MID1IP1 Gene COMPARTMENTS Subcellular localization image for MID1IP1 gene
Compartment Confidence
cytoskeleton 4
cytosol 4
nucleus 2
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for MID1IP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm --
GO:0005829 cytosol ISS --
GO:0005874 microtubule IEA --
GO:0015630 microtubule cytoskeleton ISS --
genes like me logo Genes that share ontologies with MID1IP1: view

Pathways for MID1IP1 Gene

SuperPathways for MID1IP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MID1IP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0007026 negative regulation of microtubule depolymerization ISS --
GO:0045723 positive regulation of fatty acid biosynthetic process ISS --
GO:0046890 regulation of lipid biosynthetic process ISS --
GO:0051258 protein polymerization ISS --
genes like me logo Genes that share ontologies with MID1IP1: view

No data available for Pathways by source for MID1IP1 Gene

Transcripts for MID1IP1 Gene

Unigene Clusters for MID1IP1 Gene

MID1 interacting protein 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MID1IP1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MID1IP1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c
SP1: -
SP2: - -
SP3:

Relevant External Links for MID1IP1 Gene

GeneLoc Exon Structure for
MID1IP1
ECgene alternative splicing isoforms for
MID1IP1

Expression for MID1IP1 Gene

mRNA expression in normal human tissues for MID1IP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MID1IP1 Gene

SOURCE GeneReport for Unigene cluster for MID1IP1 Gene Hs.522605

genes like me logo Genes that share expressions with MID1IP1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MID1IP1 Gene

Orthologs for MID1IP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MID1IP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MID1IP1 35
  • 99.27 (n)
  • 98.91 (a)
MID1IP1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MID1IP1 35
  • 92.49 (n)
  • 93.96 (a)
MID1IP1 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MID1IP1 35
  • 92.71 (n)
  • 93.44 (a)
MID1IP1 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mid1ip1 35
  • 89.87 (n)
  • 90.06 (a)
Mid1ip1 16
Mid1ip1 36
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MID1IP1 36
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mid1ip1 35
  • 89.74 (n)
  • 90.11 (a)
chicken
(Gallus gallus)
Aves MID1IP1 35
  • 76.1 (n)
  • 73.58 (a)
lizard
(Anolis carolinensis)
Reptilia MID1IP1 36
  • 61 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.1604 35
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75801 35
mid1ip1 35
  • 67.33 (n)
  • 70.67 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.423 35
zebrafish
(Danio rerio)
Actinopterygii g12 35
mid1ip1a 36
  • 52 (a)
OneToOne
mid1ip1b 35
  • 64.84 (n)
  • 68.49 (a)
Species with no ortholog for MID1IP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MID1IP1 Gene

ENSEMBL:
Gene Tree for MID1IP1 (if available)
TreeFam:
Gene Tree for MID1IP1 (if available)

Paralogs for MID1IP1 Gene

Paralogs for MID1IP1 Gene

Selected SIMAP similar genes for MID1IP1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MID1IP1: view

Variants for MID1IP1 Gene

Sequence variations from dbSNP and Humsavar for MID1IP1 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs9887 -- 38,806,285(-) TCCAC(A/T)TTCTC utr-variant-3-prime
rs1043814 -- 38,806,199(+) cccca(C/T)cccca utr-variant-3-prime
rs5917632 -- 38,800,428(+) AAATG(C/T)CATTC upstream-variant-2KB
rs12832786 -- 38,806,389(+) ACTTT(C/T)TTTAA utr-variant-3-prime
rs35831598 -- 38,800,442(+) CCCCC(-/C)AAAAA upstream-variant-2KB

Relevant External Links for MID1IP1 Gene

HapMap Linkage Disequilibrium report
MID1IP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MID1IP1 Gene

Disorders for MID1IP1 Gene

Relevant External Links for MID1IP1

Genetic Association Database (GAD)
MID1IP1
Human Genome Epidemiology (HuGE) Navigator
MID1IP1
genes like me logo Genes that share disorders with MID1IP1: view

No data available for UniProtKB/Swiss-Prot for MID1IP1 Gene

Publications for MID1IP1 Gene

  1. Mig12, a novel Opitz syndrome gene product partner, is expressed in the embryonic ventral midline and co-operates with Mid1 to bundle and stabilize microtubules. (PMID: 15070402) Berti C. … Meroni G. (BMC Cell Biol. 2004) 3 4 23
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual J.F. … Vidal M. (Nature 2005) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for MID1IP1 Gene

Sources for MID1IP1 Gene

Back to Top

Content