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Aliases for MICU3 Gene

Aliases for MICU3 Gene

  • Mitochondrial Calcium Uptake Family Member 3 2 3 5
  • Mitochondrial Calcium Uptake Family, Member 3 2 3
  • EF-Hand Domain-Containing Family Member A2 3 4
  • EF-Hand Domain Family, Member A2 2 3
  • EF Hand Domain Family A2 2 3
  • EFHA2 3 4
  • Mitochondrial Uptake Family, Member 3 3
  • EF Hand Domain Family, Member A2 3

External Ids for MICU3 Gene

Previous HGNC Symbols for MICU3 Gene

  • EFHA2

Previous GeneCards Identifiers for MICU3 Gene

  • GC08P016884

Summaries for MICU3 Gene

GeneCards Summary for MICU3 Gene

MICU3 (Mitochondrial Calcium Uptake Family Member 3) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is MICU1.

UniProtKB/Swiss-Prot for MICU3 Gene

  • May play a role in mitochondrial calcium uptake.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MICU3 Gene

Genomics for MICU3 Gene

Regulatory Elements for MICU3 Gene

Enhancers for MICU3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MICU3 on UCSC Golden Path with GeneCards custom track

Promoters for MICU3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MICU3 on UCSC Golden Path with GeneCards custom track

Genomic Location for MICU3 Gene

17,027,238 bp from pter
17,122,644 bp from pter
95,407 bases
Plus strand

Genomic View for MICU3 Gene

Genes around MICU3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MICU3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MICU3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MICU3 Gene

Proteins for MICU3 Gene

  • Protein details for MICU3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Calcium uptake protein 3, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • Q8IYZ3

    Protein attributes for MICU3 Gene

    530 amino acids
    Molecular mass:
    60711 Da
    Quaternary structure:
    No Data Available
    • Binds calcium.
    • Sequence=AAH32868.1; Type=Frameshift; Positions=29; Evidence={ECO:0000305};

neXtProt entry for MICU3 Gene

Proteomics data for MICU3 Gene at MOPED

Post-translational modifications for MICU3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MICU3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MICU3 Gene

Domains & Families for MICU3 Gene

Gene Families for MICU3 Gene

Protein Domains for MICU3 Gene

Suggested Antigen Peptide Sequences for MICU3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 3 EF-hand domains.
  • Belongs to the MICU1 family. MICU3 subfamily.
  • Contains 3 EF-hand domains.
  • Belongs to the MICU1 family. MICU3 subfamily.
genes like me logo Genes that share domains with MICU3: view

Function for MICU3 Gene

Molecular function for MICU3 Gene

UniProtKB/Swiss-Prot Function:
May play a role in mitochondrial calcium uptake.
genes like me logo Genes that share phenotypes with MICU3: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MICU3 Gene

Localization for MICU3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MICU3 Gene

Mitochondrion. Membrane; Single-pass membrane protein.

No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MICU3 Gene

Pathways & Interactions for MICU3 Gene

SuperPathways for MICU3 Gene

No Data Available

Interacting Proteins for MICU3 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000321455 for MICU3 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for MICU3 Gene


No data available for Pathways by source and SIGNOR curated interactions for MICU3 Gene

Drugs & Compounds for MICU3 Gene

(1) Drugs for MICU3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with MICU3: view

Transcripts for MICU3 Gene

Unigene Clusters for MICU3 Gene

Mitochondrial uptake family, member 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MICU3 Gene

No ASD Table

Relevant External Links for MICU3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MICU3 Gene

mRNA expression in normal human tissues for MICU3 Gene

mRNA differential expression in normal tissues according to GTEx for MICU3 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x4.2).

Protein differential expression in normal tissues from HIPED for MICU3 Gene

This gene is overexpressed in Frontal cortex (37.5), Placenta (15.2), and Adipocyte (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for MICU3 Gene

SOURCE GeneReport for Unigene cluster for MICU3 Gene Hs.403594

genes like me logo Genes that share expression patterns with MICU3: view

Protein tissue co-expression partners for MICU3 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for MICU3 Gene

Orthologs for MICU3 Gene

This gene was present in the common ancestor of animals.

Orthologs for MICU3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia EFHA2 35
  • 93.01 (n)
  • 93.92 (a)
MICU3 36
  • 92 (a)
(Canis familiaris)
Mammalia MICU3 35
  • 90.37 (n)
  • 91.33 (a)
MICU3 36
  • 88 (a)
(Mus musculus)
Mammalia Micu3 35
  • 90.31 (n)
  • 92.73 (a)
Micu3 16
Micu3 36
  • 93 (a)
(Pan troglodytes)
Mammalia EFHA2 35
  • 99.5 (n)
  • 99.43 (a)
EFHA2 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Micu3 35
  • 89.58 (n)
  • 92.18 (a)
(Monodelphis domestica)
Mammalia MICU3 36
  • 90 (a)
(Ornithorhynchus anatinus)
Mammalia MICU3 36
  • 86 (a)
(Gallus gallus)
Aves EFHA2 35
  • 79.92 (n)
  • 83.64 (a)
MICU3 36
  • 79 (a)
(Anolis carolinensis)
Reptilia MICU3 36
  • 71 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia micu3 35
  • 73.6 (n)
  • 76.51 (a)
(Danio rerio)
Actinopterygii micu3a 35
  • 68.53 (n)
  • 73.54 (a)
MICU3 (1 of 2) 36
  • 61 (a)
micu3a 36
  • 65 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004179 35
  • 52.61 (n)
  • 49.24 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG4662 35
  • 51.66 (n)
  • 50.26 (a)
CG4662 36
  • 42 (a)
(Caenorhabditis elegans)
Secernentea CELE_C56A3.6 35
  • 49.65 (n)
  • 37.37 (a)
C56A3.6 36
  • 33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10493 36
  • 48 (a)
Species with no ortholog for MICU3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MICU3 Gene

Gene Tree for MICU3 (if available)
Gene Tree for MICU3 (if available)

Paralogs for MICU3 Gene

Paralogs for MICU3 Gene

(2) SIMAP similar genes for MICU3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with MICU3: view

Variants for MICU3 Gene

Sequence variations from dbSNP and Humsavar for MICU3 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs2106011 -- 17,032,501(+) CATAT(C/T)TGAGT intron-variant
rs2285259 -- 17,063,922(+) tattt(A/G)tgtga intron-variant
rs2285260 -- 17,064,381(+) AGACT(C/G)ATATT intron-variant
rs2285261 -- 17,064,504(+) TGCCT(A/C)TTCAT intron-variant
rs2285262 -- 17,064,705(+) CTTGC(A/T)AATCT intron-variant

Variation tolerance for MICU3 Gene

Residual Variation Intolerance Score: 57.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.40; 77.09% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for MICU3 Gene

Disorders for MICU3 Gene

Relevant External Links for MICU3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MICU3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MICU3 Gene

Publications for MICU3 Gene

  1. MICU2, a paralog of MICU1, resides within the mitochondrial uniporter complex to regulate calcium handling. (PMID: 23409044) Plovanich M. … Mootha V.K. (PLoS ONE 2013) 2 3 67
  2. SR protein kinases promote splicing of nonconsensus introns. (PMID: 26167880) Lipp J.J. … Guthrie C. (Nat. Struct. Mol. Biol. 2015) 3
  3. Genome-wide association study of comorbid depressive syndrome and alcohol dependence. (PMID: 22064162) Edwards A.C. … Dick D.M. (Psychiatr. Genet. 2012) 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for MICU3 Gene

Sources for MICU3 Gene