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Aliases for MICU3 Gene

Aliases for MICU3 Gene

  • Mitochondrial Calcium Uptake Family, Member 3 2 3
  • EFHA2 3 4 6
  • EF-Hand Domain-Containing Family Member A2 3 4
  • EF-Hand Domain Family, Member A2 2 3
  • EF Hand Domain Family A2 2 3
  • Calcium Uptake Protein 3, Mitochondrial 3
  • Mitochondrial Uptake Family, Member 3 3
  • EF Hand Domain Family, Member A2 3

External Ids for MICU3 Gene

Previous HGNC Symbols for MICU3 Gene

  • EFHA2

Previous GeneCards Identifiers for MICU3 Gene

  • GC08P016884

Summaries for MICU3 Gene

GeneCards Summary for MICU3 Gene

MICU3 (Mitochondrial Calcium Uptake Family, Member 3) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is MICU1.

UniProtKB/Swiss-Prot for MICU3 Gene

  • May play a role in mitochondrial calcium uptake.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MICU3 Gene

Genomics for MICU3 Gene

Genomic Location for MICU3 Gene

17,027,238 bp from pter
17,122,644 bp from pter
95,407 bases
Plus strand

Genomic View for MICU3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MICU3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MICU3 Gene

No data available for Regulatory Elements for MICU3 Gene

Proteins for MICU3 Gene

  • Protein details for MICU3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Calcium uptake protein 3, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • Q8IYZ3

    Protein attributes for MICU3 Gene

    530 amino acids
    Molecular mass:
    60711 Da
    Quaternary structure:
    No Data Available
    • Binds calcium.
    • Sequence=AAH32868.1; Type=Frameshift; Positions=29; Evidence={ECO:0000305};

neXtProt entry for MICU3 Gene

Proteomics data for MICU3 Gene at MOPED

Post-translational modifications for MICU3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MICU3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MICU3 Gene

Domains for MICU3 Gene

Gene Families for MICU3 Gene

Protein Domains for MICU3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 3 EF-hand domains.
  • Belongs to the MICU1 family. MICU3 subfamily.
  • Contains 3 EF-hand domains.
  • Belongs to the MICU1 family. MICU3 subfamily.
genes like me logo Genes that share domains with MICU3: view

No data available for Suggested Antigen Peptide Sequences for MICU3 Gene

Function for MICU3 Gene

Molecular function for MICU3 Gene

UniProtKB/Swiss-Prot Function:
May play a role in mitochondrial calcium uptake.

Gene Ontology (GO) - Molecular Function for MICU3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
genes like me logo Genes that share ontologies with MICU3: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MICU3 Gene

Localization for MICU3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MICU3 Gene

Mitochondrion. Membrane; Single-pass membrane protein.

Gene Ontology (GO) - Cellular Components for MICU3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MICU3: view

No data available for Subcellular locations from COMPARTMENTS for MICU3 Gene

Pathways for MICU3 Gene

SuperPathways for MICU3 Gene

No Data Available

Interacting Proteins for MICU3 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000321455 for MICU3 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for MICU3 Gene


No data available for Pathways by source for MICU3 Gene

Drugs for MICU3 Gene

(1) HMDB Compounds for MICU3 Gene

Compound Synonyms Cas Number PubMed IDs
  • Ca
genes like me logo Genes that share compounds with MICU3: view

Transcripts for MICU3 Gene

Unigene Clusters for MICU3 Gene

Mitochondrial uptake family, member 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MICU3 Gene

No ASD Table

Relevant External Links for MICU3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MICU3 Gene

mRNA expression in normal human tissues for MICU3 Gene

mRNA differential expression in normal tissues according to GTEx for MICU3 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (4.2).

Protein differential expression in normal tissues for MICU3 Gene

This gene is overexpressed in Frontal cortex (37.5), Placenta (15.2), and Adipocyte (8.4).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for MICU3 Gene

SOURCE GeneReport for Unigene cluster for MICU3 Gene Hs.403594

genes like me logo Genes that share expressions with MICU3: view

Expression partners for MICU3 Gene

* - Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for MICU3 Gene

Orthologs for MICU3 Gene

This gene was present in the common ancestor of animals.

Orthologs for MICU3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia EFHA2 35
  • 93.01 (n)
  • 93.92 (a)
MICU3 36
  • 92 (a)
(Canis familiaris)
Mammalia MICU3 35
  • 90.37 (n)
  • 91.33 (a)
MICU3 36
  • 88 (a)
(Mus musculus)
Mammalia Micu3 35
  • 90.31 (n)
  • 92.73 (a)
Efha2 16
Micu3 36
  • 93 (a)
(Pan troglodytes)
Mammalia EFHA2 35
  • 99.5 (n)
  • 99.43 (a)
EFHA2 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Micu3 35
  • 89.58 (n)
  • 92.18 (a)
(Monodelphis domestica)
Mammalia MICU3 36
  • 90 (a)
(Ornithorhynchus anatinus)
Mammalia MICU3 36
  • 86 (a)
(Gallus gallus)
Aves EFHA2 35
  • 79.92 (n)
  • 83.64 (a)
MICU3 36
  • 79 (a)
(Anolis carolinensis)
Reptilia MICU3 36
  • 71 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia micu3 35
  • 73.6 (n)
  • 76.51 (a)
(Danio rerio)
Actinopterygii micu3a 35
  • 68.53 (n)
  • 73.54 (a)
MICU3 (1 of 2) 36
  • 61 (a)
micu3a 36
  • 65 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004179 35
  • 52.61 (n)
  • 49.24 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG4662 35
  • 51.66 (n)
  • 50.26 (a)
CG4662 36
  • 42 (a)
(Caenorhabditis elegans)
Secernentea CELE_C56A3.6 35
  • 49.65 (n)
  • 37.37 (a)
C56A3.6 36
  • 33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10493 36
  • 48 (a)
Species with no ortholog for MICU3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MICU3 Gene

Gene Tree for MICU3 (if available)
Gene Tree for MICU3 (if available)

Paralogs for MICU3 Gene

Paralogs for MICU3 Gene

(2) SIMAP similar genes for MICU3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with MICU3: view

Variants for MICU3 Gene

Sequence variations from dbSNP and Humsavar for MICU3 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs709847 -- 17,058,282(+) TATTG(A/G)ATCTA intron-variant
rs768161 -- 17,113,748(+) ATTTA(A/C)CTTAC intron-variant
rs768162 -- 17,113,881(+) TACCT(A/G)TTATT intron-variant
rs850411 -- 17,074,058(+) TGGTT(A/T)TTTTT intron-variant
rs850412 -- 17,074,214(+) ctgtt(C/T)ggtaa intron-variant

Relevant External Links for MICU3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MICU3 Gene

Disorders for MICU3 Gene

No disorders were found for MICU3 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for MICU3 Gene

Publications for MICU3 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. MICU2, a paralog of MICU1, resides within the mitochondrial uniporter complex to regulate calcium handling. (PMID: 23409044) Plovanich M. … Mootha V.K. (PLoS ONE 2013) 2 3
  3. DNA sequence and analysis of human chromosome 8. (PMID: 16421571) Nusbaum C. … Lander E.S. (Nature 2006) 4
  4. Genome-wide association study of comorbid depressive syndrome and alcohol dependence. (PMID: 22064162) Edwards A.C. … Dick D.M. (Psychiatr. Genet. 2012) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for MICU3 Gene

Sources for MICU3 Gene

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