Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



MICU2 Gene

protein-coding   GIFtS: 43
GCID: GC13M022067

Mitochondrial Calcium Uptake 2

(Previous names: EF hand domain family A1, EF-hand domain family, member...)
(Previous symbol: EFHA1)
  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Mitochondrial Calcium Uptake 21 2     1110008L20Rik2
EFHA11 2 3 5     Calcium Uptake Protein 2, Mitochondrial2
EF Hand Domain Family A11 2     EF Hand Domain Family, Member A12
EF-Hand Domain Family, Member A11 2     Smhs2 Homolog2
EF-Hand Domain-Containing Family Member A12 3     

External Ids:    HGNC: 318301   Entrez Gene: 2211542   Ensembl: ENSG000001654877   OMIM: 6106325   UniProtKB: Q8IYU83   
ORGUL members:         

Export aliases for MICU2 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for MICU2 Gene:
MICU2 (mitochondrial calcium uptake 2) is a protein-coding gene. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is MICU3.

UniProtKB/Swiss-Prot: MICU2_HUMAN, Q8IYU8
Function: Involved in mitochondrial uniporter-mediated calcium uptake. Probable regulator of the mitochondrial
calcium uniporter (MCU) (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000013.10  NT_024524.15  NC_018924.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for MICU2
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMICU2 promoter sequence
   Search Chromatin IP Primers for MICU2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MICU2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q12.11   Ensembl cytogenetic band:  13q12.11   HGNC cytogenetic band: 13q12.11

MICU2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MICU2 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M022067:  view genomic region     (about GC identifiers)

Start:
22,066,828 bp from pter      End:
22,178,355 bp from pter
Size:
111,528 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: MICU2_HUMAN, Q8IYU8 (See protein sequence)
Recommended Name: Calcium uptake protein 2, mitochondrial  
Size: 434 amino acids; 49666 Da
Subunit: Component of the uniplex complex, composed of MCU, MCUB, MICU1, MICU2 and EMRE/SMDT1
Caution: It is unsure if this protein binds calcium as none of the 4 EF-hand domains seem to contain a canonical
calcium-binding site
Sequence caution: Sequence=BAC03769.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q8N0T6 Q8NAX8

Explore the universe of human proteins at neXtProt for MICU2: NX_Q8IYU8

Explore proteomics data for MICU2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys82, Lys206, Lys214
  • Modification sites at PhosphoSitePlus

  • See MICU2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_689939.1  
    ENSEMBL proteins: 
     ENSP00000371811   ENSP00000431792  

    MICU2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for MICU2
    GenScript Custom Purified and Recombinant Proteins Services for MICU2
    Novus Biologicals MICU2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for MICU2 

     
    antibodies-online proteins for MICU2 (2 products) 

     
    antibodies-online peptides for MICU2

    MICU2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for MICU2
    Novus Biologicals MICU2 Antibodies
    Search for Antibodies for MICU2 at Abcam
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for MICU2
    antibodies-online antibodies for MICU2 (19 products) 

    MICU2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MICU2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MICU2
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for MICU2 
    antibodies-online kits for MICU2 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    EFHAND: EF-hand domain containing

    2 InterPro protein domains:
     IPR011992 EF-hand-dom_pair
     IPR002048 EF_hand_dom

    Graphical View of Domain Structure for InterPro Entry Q8IYU8

    ProtoNet protein and cluster: Q8IYU8

    UniProtKB/Swiss-Prot: MICU2_HUMAN, Q8IYU8
    Similarity: Contains 4 EF-hand domains


    Find genes that share domains with MICU2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MICU2_HUMAN, Q8IYU8
    Function: Involved in mitochondrial uniporter-mediated calcium uptake. Probable regulator of the mitochondrial
    calcium uniporter (MCU) (By similarity)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding IPI--
    GO:0046982protein heterodimerization activity IPI--
         
    Find genes that share ontologies with MICU2           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for MICU2:
     Increased S DNA content  Increased gamma-H2AX phosphory 

         1 MGI phenotypic allele for Efha1 (no phenotypes)

    Find genes that share phenotypes with MICU2           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for MICU2

    miRNA
    Products:
        
    miRTarBase miRNAs that target MICU2:
    hsa-mir-26b-5p (MIRT029201), hsa-mir-16-5p (MIRT031531)

    Block miRNA regulation of human, mouse, rat MICU2 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate MICU2
    SwitchGear 3'UTR luciferase reporter plasmidMICU2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MICU2
    Predesigned siRNA for gene silencing in human, mouse, rat MICU2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MICU2

    Clone
    Products:
         
    OriGene clones in human, mouse for MICU2 (see all 6)
    OriGene ORF clones in mouse, rat for MICU2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for MICU2
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MICU2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MICU2
    Addgene plasmids for MICU2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MICU2
    Browse ESI BIO Cell Lines and PureStem Progenitors for MICU2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MICU2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    MICU2_HUMAN, Q8IYU8: Mitochondrion intermembrane space

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion ISS--
    GO:0005758mitochondrial intermembrane space IDA--
    GO:0034704calcium channel complex ISS--
    GO:1990246uniplex complex IDA--

    Find genes that share ontologies with MICU2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MICU2
    Interactions:

        Search GeneGlobe Interaction Network for MICU2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for MICU2 (Q8IYU83 ENSP000003718114) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MBPP026863, ENSP000003482734I2D: score=1 STRING: ENSP00000348273
    SQSTM1Q135013I2D: score=2 
    CAMKK2Q96RR43I2D: score=1 
    UBCENSP000003448184STRING: ENSP00000344818
    CGNENSP000002716364STRING: ENSP00000271636
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006851mitochondrial calcium ion transport IDA--
    GO:0051561positive regulation of mitochondrial calcium ion concentration IEA--
    GO:0051562negative regulation of mitochondrial calcium ion concentration IDA--

    Find genes that share ontologies with MICU2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MICU2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for MICU2 gene: 
    NM_152726.2  

    Unigene Cluster for MICU2:

    Mitochondrial calcium uptake 2
    Hs.412103  [show with all ESTs]
    Unigene Representative Sequence: BX641028
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000479790 ENST00000382374(uc010tct.2 uc001uof.3) ENST00000460488
    ENST00000478700 ENST00000480341 ENST00000476895 ENST00000469058 ENST00000468222

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MICU2 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate MICU2
    SwitchGear 3'UTR luciferase reporter plasmidMICU2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MICU2
    Predesigned siRNA for gene silencing in human, mouse, rat MICU2
    Clone
    Products:
         
    OriGene clones in human, mouse for MICU2 (see all 6)
    OriGene ORF clones in mouse, rat for MICU2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for MICU2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MICU2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MICU2
    Addgene plasmids for MICU2 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for MICU2
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat MICU2
      QuantiTect SYBR Green Assays in human, mouse, rat MICU2
      QuantiFast Probe-based Assays in human, mouse, rat MICU2

    Additional mRNA sequence: 

    AK057745.1 AK091907.1 BC031089.1 BC034965.1 BX641028.1 

    15 DOTS entries:

    DT.97784699  DT.95107929  DT.121645717  DT.40191639  DT.86850301  DT.95301871  DT.91834848  DT.95112200 
    DT.97781195  DT.121645723  DT.86856188  DT.95301873  DT.95301875  DT.40107412  DT.65288578 

    Selected AceView cDNA sequences (see all 242):

    CR600850 AI635979 AA465202 CA503271 CA395793 CK823200 AA127671 AA730967 
    CB242740 BI917172 AA622400 Z41832 AK091907 BX953483 H89367 BM264597 
    AI633501 T35293 BM717987 BQ101231 BQ776484 CR613308 BM724540 AA594111 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    MICU2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    MICU2 Expression
    About this image

    MICU2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MICU2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.412103
        Custom PCR Arrays for MICU2
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for MICU2
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat MICU2
    QuantiTect SYBR Green Assays in human, mouse, rat MICU2
    QuantiFast Probe-based Assays in human, mouse, rat MICU2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MICU2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for MICU2 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Efha15
    Micu21
    EF hand domain family A15
    mitochondrial calcium uptake 21
    84.58(n)1
    87.15(a)1
      14 (30.51 cM)5
    685141  NM_028643.31  NP_082919.11 
     579162805 
    chicken
    (Gallus gallus)
    Aves EFHA11 EF-hand domain family, member A1 73.76(n)
    68.73(a)
      418946  XM_417140.4  XP_417140.4 
    lizard
    (Anolis carolinensis)
    Reptilia MICU26
    mitochondrial calcium uptake 2
    58(a)
    1 ↔ 1
    3(187870138-187963557)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia micu21 mitochondrial calcium uptake 2 67.9(n)
    68.66(a)
      100486652  XM_002940749.2  XP_002940795.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.281232 Transcribed sequence with weak similarity to protein more 73.73(n)    57087243 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG46626
    --
    30(a)
    1 → many
    3R(15673045-15680125)
    worm
    (Caenorhabditis elegans)
    Secernentea C56A3.66
    Protein C56A3.6, isoform d (C56A3.6) mRNA, complet...
    27(a)
    1 → many
    V(13553371-13556408) WBGene00008345


    ENSEMBL Gene Tree for MICU2 (if available)
    TreeFam Gene Tree for MICU2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for MICU2 gene
    MICU32  MICU12  
    1 SIMAP similar gene for MICU2 using alignment to 1 protein entry:     MICU2_HUMAN:
    MICU3

    Find genes that share paralogs with MICU2           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for MICU2
    PGOHUM00000243066


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for MICU2 (see all 2327)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs665082491,2
    C--2926300(+) TCTTT-/ACA/
            
    ACAAC
    1 -- int11NA 2
    rs712024241,2
    C--3054274(+) TAGTC-/TTAT/ 
    TTATTTAT
    TTATT
    1 -- int11NA 2
    rs95097601,2
    C,F,A,H--22066343(+) ATTACG/TGACAT 1 -- int114Minor allele frequency- T:0.11NS EA NA CSA 1757
    rs774028851,2
    C,F--22066509(+) GGGATC/TAGCCA 1 -- int11Minor allele frequency- T:0.09WA 118
    rs1472374561,2
    --22066555(+) CAATTG/TTCTAA 1 -- int10--------
    rs79887221,2
    C,F--22066605(+) TACCAG/TGTTTT 1 -- int13Minor allele frequency- T:0.25WA NA 240
    rs111481281,2
    C,F,A,H--22066611(+) GTTTTA/TAAAAA 1 -- int17Minor allele frequency- T:0.29NA WA EA 368
    rs1890368351,2
    C--22066631(+) ATATTC/TAGTTT 1 -- int10--------
    rs95097611,2
    C,F,A,H--22066647(+) CAATTA/CCCTTC 1 -- int118Minor allele frequency- C:0.24NA NS EA CSA WA 1973
    rs1439102871,2
    C--22066663(+) CATTT-/GTTT  
      CCCACA
    GTTTC
    1 -- int10--------

    HapMap Linkage Disequilibrium report for MICU2 (22066828 - 22178355 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for MICU2: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MICU2
    DNA2.0 Custom Variant and Variant Library Synthesis for MICU2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 610632    OMIM disorders: --


    Find genes that share disorders with MICU2           About GenesLikeMe


    Export disorders for MICU2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for MICU2 gene, integrated from 10 sources (see all 21):
    (articles sorted by number of sources associating them with MICU2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. MICU2, a paralog of MICU1, resides within the mitochondrial uniporter complex to regulate calcium handling. (PubMed id 23409044)1, 3 Plovanich M....Mootha V.K. (PLoS ONE 2013)
    2. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (Nature 2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. EMRE is an essential component of the mitochondrial calcium uniporter complex. (PubMed id 24231807)2 Sancak Y.... Mootha V.K. (Science 2013)
    6. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    8. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    9. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    10. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 221154 HGNC: 31830 AceView: FLJ34588 Ensembl:ENSG00000165487 euGenes: HUgn221154
    ECgene: MICU2 H-InvDB: MICU2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for MICU2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for MICU2 gene:
    Search GeneIP for patents involving MICU2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for MICU2  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for MICU2  
     OriGene qSTAR qPCR primer pairs in human, mouse for MICU2   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for MICU2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for MICU2   OriGene Custom Protein Services for MICU2  

     
     
     Block miRNA regulation of human, mouse, rat MICU2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing MICU2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MICU2 Predesigned siRNA for gene silencing in human, mouse, rat MICU2
     QuantiFast Probe-based Assays in human, mouse, rat MICU2 QuantiTect SYBR Green Assays in human, mouse, rat MICU2
     Custom PCR Arrays for MICU2 Search Chromatin IP Primers for MICU2
     Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat MICU2 Search GeneGlobe Interaction Network for MICU2
     Search Regulatory tfbs for MICU2
     GenScript Custom Purified and Recombinant Proteins Services for MICU2 GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for MICU2
     GenScript Custom Assay Services for MICU2 GenScript Custom overexpressing Cell Line Services for MICU2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for MICU2
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     MICU2 antibodies
     MICU2 lysates
     Search for Antibodies for MICU2 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for MICU2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for MICU2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MICU2
     SwitchGear 3'UTR luciferase reporter plasmids for MICU2
     SwitchGear Promoter luciferase reporter plasmids for MICU2
     ThermoFisher Antibodies for MICU2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MICU2
     Browse compounds at ApexBio
     Addgene plasmids for MICU2
      Search eBioscience for proteins for MICU2
      Search eBioscience for elisas for MICU2
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for MICU2
     antibodies-online antibodies for MICU2 (19 products)
     antibodies-online kits for MICU2 (6 products)
     antibodies-online peptides for MICU2
     antibodies-online proteins for MICU2 (2 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      MICU2 gene at Home site.
    Version: 3.12.258 10 Dec 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4