Aliases for MICU2 Gene
External Ids for MICU2 Gene
Previous Symbols for MICU2 Gene
GeneCards Summary for MICU2 Gene
MICU2 (Mitochondrial Calcium Uptake 2) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is MICU1.
UniProtKB/Swiss-Prot for MICU2 Gene
Key regulator of mitochondrial calcium uniporter (MCU) required to limit calcium uptake by MCU when cytoplasmic calcium is low. MICU1 and MICU2 form a disulfide-linked heterodimer that stimulate and inhibit MCU activity, respectively. MICU2 acts as a gatekeeper of MCU that senses calcium level via its EF-hand domains: prevents channel opening at resting Ca(2+), avoiding energy dissipation and cell-death triggering.