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Aliases for MICU2 Gene

Aliases for MICU2 Gene

  • Mitochondrial Calcium Uptake 2 2 3
  • EFHA1 3 4 6
  • EF-Hand Domain-Containing Family Member A1 3 4
  • EF-Hand Domain Family, Member A1 2 3
  • EF Hand Domain Family A1 2 3
  • Calcium Uptake Protein 2, Mitochondrial 3
  • EF Hand Domain Family, Member A1 3
  • Smhs2 Homolog 3
  • 1110008L20Rik 3

External Ids for MICU2 Gene

Previous Symbols for MICU2 Gene

  • EFHA1

Summaries for MICU2 Gene

GeneCards Summary for MICU2 Gene

MICU2 (Mitochondrial Calcium Uptake 2) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is MICU1.

UniProtKB/Swiss-Prot for MICU2 Gene

  • Key regulator of mitochondrial calcium uniporter (MCU) required to limit calcium uptake by MCU when cytoplasmic calcium is low. MICU1 and MICU2 form a disulfide-linked heterodimer that stimulate and inhibit MCU activity, respectively. MICU2 acts as a gatekeeper of MCU that senses calcium level via its EF-hand domains: prevents channel opening at resting Ca(2+), avoiding energy dissipation and cell-death triggering.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MICU2 Gene

Genomics for MICU2 Gene

Genomic Location for MICU2 Gene

Start:
21,492,689 bp from pter
End:
21,604,216 bp from pter
Size:
111,528 bases
Orientation:
Minus strand

Genomic View for MICU2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MICU2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MICU2 Gene

No data available for Regulatory Elements for MICU2 Gene

Proteins for MICU2 Gene

  • Protein details for MICU2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IYU8-MICU2_HUMAN
    Recommended name:
    Calcium uptake protein 2, mitochondrial
    Protein Accession:
    Q8IYU8
    Secondary Accessions:
    • Q8N0T6
    • Q8NAX8

    Protein attributes for MICU2 Gene

    Size:
    434 amino acids
    Molecular mass:
    49666 Da
    Quaternary structure:
    • Heterodimer; disulfide-linked; heterodimerizes with MICU1. Component of the uniplex complex, composed of MCU, MCUB, MICU1, MICU2 and EMRE/SMDT1.
    SequenceCaution:
    • Sequence=BAC03769.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for MICU2 Gene

Proteomics data for MICU2 Gene at MOPED

Post-translational modifications for MICU2 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys82, Lys206, and Lys214

Other Protein References for MICU2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MICU2 Gene

Domains for MICU2 Gene

Gene Families for MICU2 Gene

HGNC:
  • EFHAND :EF-hand domain containing

Protein Domains for MICU2 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

MICU2_HUMAN
Domain:
  • The EF-hand domains have high affinity for calcium and act as sensors of mitochondrial matrix calcium levels (PubMed:24503055). It is unclear which EF-hand binds calcium as none of the 4 EF-hand domains seem to contain a canonical calcium-binding site.:
    • Q8IYU8
  • Contains 4 EF-hand domains.:
    • Q8IYU8
Family:
  • Belongs to the MICU1 family. MICU2 subfamily.:
    • Q8IYU8
genes like me logo Genes that share domains with MICU2: view

Function for MICU2 Gene

Molecular function for MICU2 Gene

UniProtKB/Swiss-Prot Function: Key regulator of mitochondrial calcium uniporter (MCU) required to limit calcium uptake by MCU when cytoplasmic calcium is low. MICU1 and MICU2 form a disulfide-linked heterodimer that stimulate and inhibit MCU activity, respectively. MICU2 acts as a gatekeeper of MCU that senses calcium level via its EF-hand domains: prevents channel opening at resting Ca(2+), avoiding energy dissipation and cell-death triggering.

Gene Ontology (GO) - Molecular Function for MICU2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 24560927
GO:0046982 protein heterodimerization activity IPI 24560927
genes like me logo Genes that share ontologies with MICU2: view

Phenotypes for MICU2 Gene

GenomeRNAi human phenotypes for MICU2:
genes like me logo Genes that share phenotypes with MICU2: view

miRNA for MICU2 Gene

miRTarBase miRNAs that target MICU2

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for MICU2 Gene

Localization for MICU2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MICU2 Gene

Mitochondrion intermembrane space.

Gene Ontology (GO) - Cellular Components for MICU2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion ISS --
GO:0005758 mitochondrial intermembrane space IDA 22925203
GO:0034704 calcium channel complex ISS --
GO:1990246 uniplex complex IDA 22925203
genes like me logo Genes that share ontologies with MICU2: view

Pathways for MICU2 Gene

SuperPathways for MICU2 Gene

No Data Available

Interacting Proteins for MICU2 Gene

Gene Ontology (GO) - Biological Process for MICU2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006851 mitochondrial calcium ion transport IDA 24560927
GO:0051561 positive regulation of mitochondrial calcium ion concentration IEA --
GO:0051562 negative regulation of mitochondrial calcium ion concentration IDA 24560927
genes like me logo Genes that share ontologies with MICU2: view

No data available for Pathways by source for MICU2 Gene

Transcripts for MICU2 Gene

Unigene Clusters for MICU2 Gene

Mitochondrial calcium uptake 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MICU2 Gene

No ASD Table

Relevant External Links for MICU2 Gene

GeneLoc Exon Structure for
MICU2
ECgene alternative splicing isoforms for
MICU2

Expression for MICU2 Gene

mRNA expression in normal human tissues for MICU2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MICU2 Gene

SOURCE GeneReport for Unigene cluster for MICU2 Gene Hs.412103

genes like me logo Genes that share expressions with MICU2: view

Orthologs for MICU2 Gene

This gene was present in the common ancestor of animals.

Orthologs for MICU2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EFHA1 36
  • 99.31 (n)
  • 98.85 (a)
EFHA1 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia EFHA1 36
  • 85.43 (n)
  • 84.65 (a)
EFHA1 37
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MICU2 36
  • 88.12 (n)
  • 85.51 (a)
MICU2 37
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Efha1 16
Micu2 36
  • 84.58 (n)
  • 87.15 (a)
Micu2 37
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MICU2 37
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MICU2 37
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Micu2 36
  • 84.84 (n)
  • 85.15 (a)
chicken
(Gallus gallus)
Aves EFHA1 36
  • 73.76 (n)
  • 68.73 (a)
MICU2 37
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MICU2 37
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia micu2 36
  • 67.9 (n)
  • 68.66 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.28123 36
micu2 36
  • 59.54 (n)
  • 53.85 (a)
micu2 37
  • 48 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG4662 37
  • 30 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C56A3.6 37
  • 27 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10493 37
  • 33 (a)
OneToMany
Species with no ortholog for MICU2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MICU2 Gene

ENSEMBL:
Gene Tree for MICU2 (if available)
TreeFam:
Gene Tree for MICU2 (if available)

Paralogs for MICU2 Gene

Paralogs for MICU2 Gene

Selected SIMAP similar genes for MICU2 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for MICU2 Gene

genes like me logo Genes that share paralogs with MICU2: view

Variants for MICU2 Gene

Sequence variations from dbSNP and Humsavar for MICU2 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs718426 -- 21,511,520(-) tacca(C/T)tgtgt intron-variant
rs1022859 -- 21,576,785(-) ATTTG(A/G)TGATA intron-variant
rs1022860 -- 21,542,948(+) AACAA(C/T)ACCAG intron-variant
rs1028666 -- 21,514,471(+) TCAAA(A/T)CAACC intron-variant
rs1041020 -- 21,599,043(+) ACCTA(C/T)TGTGA intron-variant

Relevant External Links for MICU2 Gene

HapMap Linkage Disequilibrium report
MICU2

No data available for Structural Variations from Database of Genomic Variants (DGV) for MICU2 Gene

Disorders for MICU2 Gene

No disorders were found for MICU2 Gene.

No data available for UniProtKB/Swiss-Prot for MICU2 Gene

Publications for MICU2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A. … Ross M.T. (Nature 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. MICU2, a paralog of MICU1, resides within the mitochondrial uniporter complex to regulate calcium handling. (PMID: 23409044) Plovanich M. … Mootha V.K. (PLoS ONE 2013) 2 3
  5. MICU1 and MICU2 play nonredundant roles in the regulation of the mitochondrial calcium uniporter. (PMID: 24503055) Kamer K.J. … Mootha V.K. (EMBO Rep. 2014) 3 4

Products for MICU2 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate MICU2
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for MICU2
    • Block miRNA regulation of MICU2 using miScript Target Protectors
    • Addgene plasmids for MICU2

    Sources for MICU2 Gene

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