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Aliases for MICU2 Gene

Aliases for MICU2 Gene

  • Mitochondrial Calcium Uptake 2 2 3 5
  • EF-Hand Domain-Containing Family Member A1 3 4
  • EF Hand Domain Family A1 2 3
  • EFHA1 3 4
  • Calcium Uptake Protein 2, Mitochondrial 3
  • EF-Hand Domain Family, Member A1 2
  • EF Hand Domain Family, Member A1 3
  • Smhs2 Homolog 3
  • 1110008L20Rik 3

External Ids for MICU2 Gene

Previous HGNC Symbols for MICU2 Gene

  • EFHA1

Previous GeneCards Identifiers for MICU2 Gene

  • GC13M022067

Summaries for MICU2 Gene

GeneCards Summary for MICU2 Gene

MICU2 (Mitochondrial Calcium Uptake 2) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding and protein heterodimerization activity. An important paralog of this gene is MICU3.

UniProtKB/Swiss-Prot for MICU2 Gene

  • Key regulator of mitochondrial calcium uniporter (MCU) required to limit calcium uptake by MCU when cytoplasmic calcium is low (PubMed:24503055, PubMed:24560927, PubMed:26903221). MICU1 and MICU2 form a disulfide-linked heterodimer that stimulate and inhibit MCU activity, depending on the concentration of calcium (PubMed:24560927). MICU2 acts as a gatekeeper of MCU that senses calcium level via its EF-hand domains: prevents channel opening at resting calcium, avoiding energy dissipation and cell-death triggering (PubMed:24560927).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MICU2 Gene

Genomics for MICU2 Gene

Regulatory Elements for MICU2 Gene

Enhancers for MICU2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH13F021583 0.5 ENCODE 11.3 +20.5 20480 0.7 TEAD1 POLR2A TEAD4 ZNF644 SETDB1 TEAD3 MICU2 ZDHHC20 RNU6-59P GC13M021552
GH13F021616 0.8 Ensembl ENCODE 9.1 -12.7 -12679 1.4 SOX13 ELF3 TBP ZNF792 SAP130 ZNF384 ZNF644 RARA ZNF7 TEAD3 MICU2 RPS7P10
GH13F021602 0.4 ENCODE 7.7 +0.3 302 2.3 CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 ZNF207 MICU2 RNU6-59P GC13M021552
GH13F021579 0.6 Ensembl ENCODE 7.2 +23.5 23535 1.8 CTCF CTBP1 MICU2 RNU6-59P GC13M021552
GH13F021528 0.9 Ensembl ENCODE 7.1 +75.0 74971 1.9 CTCF GATA3 JUND MICU2 FNTAP2 GC13P021491
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MICU2 on UCSC Golden Path with GeneCards custom track

Promoters for MICU2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000150700 516 2200 CREB3L1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 ZNF143

Genomic Location for MICU2 Gene

Chromosome:
13
Start:
21,492,689 bp from pter
End:
21,604,216 bp from pter
Size:
111,528 bases
Orientation:
Minus strand

Genomic View for MICU2 Gene

Genes around MICU2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MICU2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MICU2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MICU2 Gene

Proteins for MICU2 Gene

  • Protein details for MICU2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IYU8-MICU2_HUMAN
    Recommended name:
    Calcium uptake protein 2, mitochondrial
    Protein Accession:
    Q8IYU8
    Secondary Accessions:
    • Q8N0T6
    • Q8NAX8

    Protein attributes for MICU2 Gene

    Size:
    434 amino acids
    Molecular mass:
    49666 Da
    Quaternary structure:
    • Heterodimer; disulfide-linked; heterodimerizes with MICU1 (PubMed:24560927). Interacts with MCU (PubMed:26341627). The heterodimer formed with MICU1 associates with MCU at low calcium concentration and dissociates from MCU at high calcium level (PubMed:26387864). Component of the uniplex complex, composed of MCU, MCUB, MICU1, MICU2 and EMRE/SMDT1 (PubMed:24231807).
    SequenceCaution:
    • Sequence=BAC03769.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for MICU2 Gene

Post-translational modifications for MICU2 Gene

  • Ubiquitination at Lys 82, Lys 206, and Lys 214
  • Modification sites at PhosphoSitePlus

Other Protein References for MICU2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MICU2 Gene

Domains & Families for MICU2 Gene

Gene Families for MICU2 Gene

Protein Domains for MICU2 Gene

Suggested Antigen Peptide Sequences for MICU2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IYU8

UniProtKB/Swiss-Prot:

MICU2_HUMAN :
  • The EF-hand domains have high affinity for calcium and act as sensors of mitochondrial matrix calcium levels (PubMed:24503055). It is unclear which EF-hand binds calcium as none of the 4 EF-hand domains seem to contain a canonical calcium-binding site.
  • Belongs to the MICU1 family. MICU2 subfamily.
Domain:
  • The EF-hand domains have high affinity for calcium and act as sensors of mitochondrial matrix calcium levels (PubMed:24503055). It is unclear which EF-hand binds calcium as none of the 4 EF-hand domains seem to contain a canonical calcium-binding site.
  • Contains 4 EF-hand domains.
Family:
  • Belongs to the MICU1 family. MICU2 subfamily.
genes like me logo Genes that share domains with MICU2: view

Function for MICU2 Gene

Molecular function for MICU2 Gene

UniProtKB/Swiss-Prot Function:
Key regulator of mitochondrial calcium uniporter (MCU) required to limit calcium uptake by MCU when cytoplasmic calcium is low (PubMed:24503055, PubMed:24560927, PubMed:26903221). MICU1 and MICU2 form a disulfide-linked heterodimer that stimulate and inhibit MCU activity, depending on the concentration of calcium (PubMed:24560927). MICU2 acts as a gatekeeper of MCU that senses calcium level via its EF-hand domains: prevents channel opening at resting calcium, avoiding energy dissipation and cell-death triggering (PubMed:24560927).

Gene Ontology (GO) - Molecular Function for MICU2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 24560927
GO:0046982 protein heterodimerization activity IPI 24560927
genes like me logo Genes that share ontologies with MICU2: view
genes like me logo Genes that share phenotypes with MICU2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for MICU2

miRNA for MICU2 Gene

miRTarBase miRNAs that target MICU2

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for MICU2

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MICU2 Gene

Localization for MICU2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MICU2 Gene

Mitochondrion intermembrane space.

Gene Ontology (GO) - Cellular Components for MICU2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005739 mitochondrion ISS,IDA --
GO:0005743 mitochondrial inner membrane IDA 27099988
GO:0005758 mitochondrial intermembrane space IEA,IDA 22925203
GO:0034704 calcium channel complex ISS --
genes like me logo Genes that share ontologies with MICU2: view

No data available for Subcellular locations from COMPARTMENTS for MICU2 Gene

Pathways & Interactions for MICU2 Gene

SuperPathways for MICU2 Gene

No Data Available

Interacting Proteins for MICU2 Gene

Gene Ontology (GO) - Biological Process for MICU2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006851 mitochondrial calcium ion transport IDA 24560927
GO:0036444 mitochondrial calcium uptake IMP 26903221
GO:0051560 mitochondrial calcium ion homeostasis IMP 26903221
GO:0051561 positive regulation of mitochondrial calcium ion concentration IEA --
GO:0051562 negative regulation of mitochondrial calcium ion concentration IDA 24560927
genes like me logo Genes that share ontologies with MICU2: view

No data available for Pathways by source and SIGNOR curated interactions for MICU2 Gene

Drugs & Compounds for MICU2 Gene

(1) Drugs for MICU2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with MICU2: view

Transcripts for MICU2 Gene

Unigene Clusters for MICU2 Gene

Mitochondrial calcium uptake 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for MICU2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MICU2 Gene

No ASD Table

Relevant External Links for MICU2 Gene

GeneLoc Exon Structure for
MICU2
ECgene alternative splicing isoforms for
MICU2

Expression for MICU2 Gene

mRNA expression in normal human tissues for MICU2 Gene

Protein differential expression in normal tissues from HIPED for MICU2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (16.5) and Stomach (10.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MICU2 Gene



Protein tissue co-expression partners for MICU2 Gene

NURSA nuclear receptor signaling pathways regulating expression of MICU2 Gene:

MICU2

SOURCE GeneReport for Unigene cluster for MICU2 Gene:

Hs.412103
genes like me logo Genes that share expression patterns with MICU2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MICU2 Gene

Orthologs for MICU2 Gene

This gene was present in the common ancestor of animals.

Orthologs for MICU2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EFHA1 34 35
  • 99.31 (n)
dog
(Canis familiaris)
Mammalia MICU2 34 35
  • 88.12 (n)
cow
(Bos Taurus)
Mammalia EFHA1 34 35
  • 85.43 (n)
rat
(Rattus norvegicus)
Mammalia Micu2 34
  • 84.84 (n)
mouse
(Mus musculus)
Mammalia Micu2 34 16 35
  • 84.58 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MICU2 35
  • 76 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MICU2 35
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves EFHA1 34
  • 73.76 (n)
MICU2 35
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MICU2 35
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia micu2 34
  • 67.9 (n)
zebrafish
(Danio rerio)
Actinopterygii micu2 34 35
  • 59.54 (n)
Dr.28123 34
fruit fly
(Drosophila melanogaster)
Insecta CG4662 35
  • 30 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C56A3.6 35
  • 27 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10493 35
  • 33 (a)
OneToMany
Species where no ortholog for MICU2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MICU2 Gene

ENSEMBL:
Gene Tree for MICU2 (if available)
TreeFam:
Gene Tree for MICU2 (if available)

Paralogs for MICU2 Gene

Paralogs for MICU2 Gene

(1) SIMAP similar genes for MICU2 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for MICU2 Gene

genes like me logo Genes that share paralogs with MICU2: view

Variants for MICU2 Gene

Sequence variations from dbSNP and Humsavar for MICU2 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs1022859 -- 21,576,785(-) ATTTG(A/G)TGATA intron-variant
rs1022860 -- 21,542,948(+) AACAA(C/T)ACCAG intron-variant
rs1028666 -- 21,514,471(+) TCAAA(A/T)CAACC intron-variant
rs1041020 -- 21,599,043(+) ACCTA(C/T)TGTGA intron-variant
rs1041021 -- 21,514,222(+) GTTAT(A/G)TGGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MICU2 Gene

Variant ID Type Subtype PubMed ID
esv2662411 CNV deletion 23128226
esv3631464 CNV gain 21293372
nsv1054982 CNV gain 25217958
nsv1078303 OTHER inversion 25765185
nsv1140246 OTHER inversion 24896259
nsv1151909 OTHER inversion 26484159
nsv525610 CNV loss 19592680
nsv528507 CNV gain 19592680
nsv832560 CNV loss 17160897
nsv952 CNV deletion 18451855
nsv953 CNV insertion 18451855
nsv955 CNV deletion 18451855
nsv976086 CNV duplication 23825009

Variation tolerance for MICU2 Gene

Residual Variation Intolerance Score: 67.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.29; 40.93% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MICU2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MICU2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MICU2 Gene

Disorders for MICU2 Gene

Relevant External Links for MICU2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MICU2

No disorders were found for MICU2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MICU2 Gene

Publications for MICU2 Gene

  1. Functional roles of MICU1 and MICU2 in mitochondrial Ca(2+) uptake. (PMID: 26903221) Matesanz-Isabel J. … Alvarez J. (Biochim. Biophys. Acta 2016) 3 4 64
  2. Dual functions of a small regulatory subunit in the mitochondrial calcium uniporter complex. (PMID: 27099988) Tsai M.F. … Miller C. (Elife 2016) 3 4 64
  3. The Ca(2+)-dependent release of the Mia40-induced MICU1-MICU2 dimer from MCU regulates mitochondrial Ca(2+) uptake. (PMID: 26387864) Petrungaro C. … Riemer J. (Cell Metab. 2015) 3 4 64
  4. MICU1 and MICU2 play nonredundant roles in the regulation of the mitochondrial calcium uniporter. (PMID: 24503055) Kamer K.J. … Mootha V.K. (EMBO Rep. 2014) 3 4 64
  5. MICU1 and MICU2 finely tune the mitochondrial Ca(2+) uniporter by exerting opposite effects on MCU activity. (PMID: 24560927) Patron M. … Rizzuto R. (Mol. Cell 2014) 3 4 64

Products for MICU2 Gene

Sources for MICU2 Gene

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