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Aliases for MICU1 Gene

Aliases for MICU1 Gene

  • Mitochondrial Calcium Uptake 1 2 3 5
  • Calcium-Binding Atopy-Related Autoantigen 1 3 4
  • Atopy-Related Autoantigen CALC 3 4
  • Ara CALC 3 4
  • CBARA1 3 4
  • CALC 3 4
  • Calcium Binding Atopy-Related Autoantigen 1 2
  • Calcium Uptake Protein 1, Mitochondrial 3
  • Allergen Hom S 4 4
  • EFHA3 3
  • MPXPS 3

External Ids for MICU1 Gene

Previous HGNC Symbols for MICU1 Gene

  • CBARA1

Previous GeneCards Identifiers for MICU1 Gene

  • GC10M074128

Summaries for MICU1 Gene

Entrez Gene Summary for MICU1 Gene

  • This gene encodes an essential regulator of mitochondrial Ca2+ uptake under basal conditions. The encoded protein interacts with the mitochondrial calcium uniporter, a mitochondrial inner membrane Ca2+ channel, and is essential in preventing mitochondrial Ca2+ overload, which can cause excessive production of reactive oxygen species and cell stress. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Mar 2013]

GeneCards Summary for MICU1 Gene

MICU1 (Mitochondrial Calcium Uptake 1) is a Protein Coding gene. Diseases associated with MICU1 include Myopathy With Extrapyramidal Signs and Fish Allergy. Among its related pathways are Ca, cAMP and Lipid Signaling. GO annotations related to this gene include calcium ion binding and protein heterodimerization activity. An important paralog of this gene is MICU3.

UniProtKB/Swiss-Prot for MICU1 Gene

  • Key regulator of mitochondrial calcium uniporter (MCU) that senses calcium level via its EF-hand domains (PubMed:20693986, PubMed:23101630, PubMed:23747253, PubMed:24313810, PubMed:24332854, PubMed:24503055, PubMed:24560927, PubMed:26341627, PubMed:26903221, PubMed:27099988). MICU1 and MICU2 form a disulfide-linked heterodimer that stimulates and inhibits MCU activity, depending on the concentration of calcium. MICU1 acts both as an activator or inhibitor of mitochondrial calcium uptake (PubMed:26903221). Acts as a gatekeeper of MCU at low concentration of calcium, preventing channel opening (PubMed:26903221). Enhances MCU opening at high calcium concentration, allowing a rapid response of mitochondria to calcium signals generated in the cytoplasm (PubMed:24560927, PubMed:26903221). Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake (PubMed:22904319). Induces T-helper 1-mediated autoreactivity, which is accompanied by the release of IFNG (PubMed:16002733).

Gene Wiki entry for MICU1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MICU1 Gene

Genomics for MICU1 Gene

Regulatory Elements for MICU1 Gene

Enhancers for MICU1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10F072689 1.6 FANTOM5 Ensembl ENCODE 11.6 -65.4 -65416 4.8 PKNOX1 CREB3L1 ARID4B SIN3A YBX1 FEZF1 YY1 SLC30A9 FOS ZNF263 DNAJB12 ECD MICU1 ENSG00000272791 ENSG00000268584 CHST3 MCU GC10M072655 ENSG00000201881
GH10F072675 1.5 FANTOM5 Ensembl ENCODE 11.1 -50.7 -50714 2.1 HDGF ATF1 PKNOX1 SIN3A FOS JUNB MAFF SMARCA4 HMBOX1 SP7 MICU1 DNAJB12 RNU6-805P ENSG00000226163 MCU ASCC1 ENSG00000201881 GC10M072655
GH10F072679 0.9 ENCODE 11.1 -53.8 -53781 1.8 ELF3 HDAC1 TBP DMAP1 RAD21 ETV6 CREM SP5 KAT8 SMARCA4 MICU1 RNU6-805P ENSG00000226163 MCU GC10M072655 ENSG00000201881
GH10F072702 0.9 Ensembl ENCODE 10.8 -77.1 -77110 1.0 PKNOX1 ZFP64 FEZF1 TBX21 ZNF843 RAD21 OSR2 ZNF664 ZNF610 SMC3 DNAJB12 MICU1 ENSG00000237768 ENSG00000226163 OIT3 GC10P072699 GC10P072715
GH10F072672 0.8 ENCODE 11.1 -47.1 -47137 1.5 PKNOX1 ZEB1 ZNF664 GATA3 GATA2 ZNF207 NFE2 MAFK NFE2L2 HLF DNAJB12 ENSG00000227540 MICU1 ENSG00000272791 RNU6-805P ENSG00000226163 MCU GC10M072655 ENSG00000201881
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MICU1 on UCSC Golden Path with GeneCards custom track

Promoters for MICU1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000643205 391 2401 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143

Genomic Location for MICU1 Gene

Chromosome:
10
Start:
72,367,326 bp from pter
End:
72,626,191 bp from pter
Size:
258,866 bases
Orientation:
Minus strand

Genomic View for MICU1 Gene

Genes around MICU1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MICU1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MICU1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MICU1 Gene

Proteins for MICU1 Gene

  • Protein details for MICU1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BPX6-MICU1_HUMAN
    Recommended name:
    Calcium uptake protein 1, mitochondrial
    Protein Accession:
    Q9BPX6
    Secondary Accessions:
    • A8MV96
    • B3KN20
    • B4DJH9
    • B4DPI1
    • B5MBY3
    • D3YTJ3
    • O75785
    • Q9H9N6
    • Q9UFX0

    Protein attributes for MICU1 Gene

    Size:
    476 amino acids
    Molecular mass:
    54351 Da
    Quaternary structure:
    • Homohexamer; in absence of calcium (PubMed:24514027). Forms a homohexamer in absence of calcium and rearranges into a heterodimer in presence of calcium (PubMed:26489515, PubMed:24514027). Heterodimer; disulfide-linked; heterodimerizes with MICU2 (PubMed:24560927). The heterodimer formed with MICU2 associates with MCU at low calcium concentration and dissociates from MCU at high calcium level (PubMed:26387864). Component of the uniplex complex, composed of MCU, MCUB, MICU1, MICU2 and EMRE/SMDT1 (PubMed:24231807). Interacts (via polybasic region) with EMRE/SMDT1; the interaction is direct (PubMed:27099988). Interacts (via polybasic region) with MCU (via coiled coil domains); the interaction is direct and precedes formation of the heterodimer with MICU2 (PubMed:21685886, PubMed:23101630, PubMed:23178883, PubMed:24332854, PubMed:26387864). Interacts with SLC25A23 (PubMed:24430870). Interacts with CHCHD4/MIA40; which introduces the interchain disulfide bond with MICU2 (PubMed:26387864).
    SequenceCaution:
    • Sequence=BAB14187.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAA76830.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MICU1 Gene

    Alternative splice isoforms for MICU1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MICU1 Gene

Post-translational modifications for MICU1 Gene

  • Ubiquitination at Lys 294
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for MICU1 Gene

Domains & Families for MICU1 Gene

Gene Families for MICU1 Gene

Protein Domains for MICU1 Gene

Suggested Antigen Peptide Sequences for MICU1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BPX6

UniProtKB/Swiss-Prot:

MICU1_HUMAN :
  • The C-helix is required for assembling the Ca(2+)-free homohexamer (PubMed:24514027). It also plays a key role in mitochondrial calcium uptake, probably by mediating interaction with MICU2 (PubMed:24503055, PubMed:24514027).
  • Belongs to the MICU1 family. MICU1 subfamily.
Domain:
  • The C-helix is required for assembling the Ca(2+)-free homohexamer (PubMed:24514027). It also plays a key role in mitochondrial calcium uptake, probably by mediating interaction with MICU2 (PubMed:24503055, PubMed:24514027).
  • The EF-hand domains have high affinity for calcium and act as sensors of calcium levels (PubMed:23101630, PubMed:24560927).
  • Contains 2 EF-hand domains.
Family:
  • Belongs to the MICU1 family. MICU1 subfamily.
genes like me logo Genes that share domains with MICU1: view

Function for MICU1 Gene

Molecular function for MICU1 Gene

UniProtKB/Swiss-Prot Function:
Key regulator of mitochondrial calcium uniporter (MCU) that senses calcium level via its EF-hand domains (PubMed:20693986, PubMed:23101630, PubMed:23747253, PubMed:24313810, PubMed:24332854, PubMed:24503055, PubMed:24560927, PubMed:26341627, PubMed:26903221, PubMed:27099988). MICU1 and MICU2 form a disulfide-linked heterodimer that stimulates and inhibits MCU activity, depending on the concentration of calcium. MICU1 acts both as an activator or inhibitor of mitochondrial calcium uptake (PubMed:26903221). Acts as a gatekeeper of MCU at low concentration of calcium, preventing channel opening (PubMed:26903221). Enhances MCU opening at high calcium concentration, allowing a rapid response of mitochondria to calcium signals generated in the cytoplasm (PubMed:24560927, PubMed:26903221). Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake (PubMed:22904319). Induces T-helper 1-mediated autoreactivity, which is accompanied by the release of IFNG (PubMed:16002733).

Gene Ontology (GO) - Molecular Function for MICU1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IDA 23101630
GO:0005515 protein binding IPI 21685886
GO:0042802 identical protein binding IPI 24514027
GO:0046872 metal ion binding IEA --
GO:0046982 protein heterodimerization activity IPI 24560927
genes like me logo Genes that share ontologies with MICU1: view
genes like me logo Genes that share phenotypes with MICU1: view

Human Phenotype Ontology for MICU1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

miRNA for MICU1 Gene

miRTarBase miRNAs that target MICU1

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for MICU1 Gene

Localization for MICU1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MICU1 Gene

Mitochondrion inner membrane; Single-pass membrane protein. Mitochondrion intermembrane space. Note=The topology is subject to discussion. According to some reports, localizes at the outer surface of the mitochondrion inner membrane (PubMed:20693986, PubMed:24332854). According to another publication, forms a intramembrane hairpin loop without crossing the membrane (PubMed:23747253). Recent studies rather suggest that it contains a transmembrane region that crosses the mitochondrial inner membrane, with the main part of the protein localized in the mitochondrial intermembrane space (PubMed:26387864, PubMed:26489515). {ECO:0000269 PubMed:20693986, ECO:0000269 PubMed:23747253, ECO:0000269 PubMed:24332854, ECO:0000269 PubMed:26387864, ECO:0000269 PubMed:26489515}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MICU1 gene
Compartment Confidence
mitochondrion 5
nucleus 2
cytosol 2
plasma membrane 1
peroxisome 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for MICU1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular TAS 9806765
GO:0005739 mitochondrion IDA --
GO:0005743 mitochondrial inner membrane IMP 27099988
GO:0005758 mitochondrial intermembrane space IEA,IDA 24231807
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with MICU1: view

Pathways & Interactions for MICU1 Gene

SuperPathways for MICU1 Gene

SuperPathway Contained pathways
1 Ca, cAMP and Lipid Signaling
genes like me logo Genes that share pathways with MICU1: view

Pathways by source for MICU1 Gene

1 Cell Signaling Technology pathway for MICU1 Gene

Gene Ontology (GO) - Biological Process for MICU1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0006816 calcium ion transport IEA --
GO:0006851 mitochondrial calcium ion transport IMP 23101630
GO:0006952 defense response TAS 9806765
genes like me logo Genes that share ontologies with MICU1: view

No data available for SIGNOR curated interactions for MICU1 Gene

Transcripts for MICU1 Gene

Unigene Clusters for MICU1 Gene

Mitochondrial calcium uptake 1:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MICU1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1: - - -
SP2: -
SP3:
SP4:

Relevant External Links for MICU1 Gene

GeneLoc Exon Structure for
MICU1
ECgene alternative splicing isoforms for
MICU1

Expression for MICU1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MICU1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MICU1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (35.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MICU1 Gene



Protein tissue co-expression partners for MICU1 Gene

NURSA nuclear receptor signaling pathways regulating expression of MICU1 Gene:

MICU1

SOURCE GeneReport for Unigene cluster for MICU1 Gene:

Hs.524367

mRNA Expression by UniProt/SwissProt for MICU1 Gene:

Q9BPX6-MICU1_HUMAN
Tissue specificity: Expressed in epithelial cell lines. Strongly expressed in epidermal keratinocytes and dermal endothelial cells.
genes like me logo Genes that share expression patterns with MICU1: view

No data available for mRNA differential expression in normal tissues for MICU1 Gene

Orthologs for MICU1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MICU1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MICU1 34 35
  • 99.87 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MICU1 35
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MICU1 34 35
  • 92.79 (n)
cow
(Bos Taurus)
Mammalia MICU1 34 35
  • 92.72 (n)
mouse
(Mus musculus)
Mammalia Micu1 34 16 35
  • 86.88 (n)
rat
(Rattus norvegicus)
Mammalia Micu1 34
  • 86.74 (n)
oppossum
(Monodelphis domestica)
Mammalia MICU1 35
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves MICU1 34 35
  • 78.01 (n)
lizard
(Anolis carolinensis)
Reptilia MICU1 35
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia micu1 34
  • 75.19 (n)
Str.18083 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.21702 34
zebrafish
(Danio rerio)
Actinopterygii micu1 34 35
  • 71.24 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009117 34
  • 59.07 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG4495 34 35
  • 59.05 (n)
CG4704 35
  • 35 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea micu-1 34 35
  • 55.26 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G32060 34
  • 46.99 (n)
rice
(Oryza sativa)
Liliopsida Os04g0502900 34
  • 44.6 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7252 35
  • 51 (a)
OneToOne
Species where no ortholog for MICU1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MICU1 Gene

ENSEMBL:
Gene Tree for MICU1 (if available)
TreeFam:
Gene Tree for MICU1 (if available)

Paralogs for MICU1 Gene

Paralogs for MICU1 Gene

(1) SIMAP similar genes for MICU1 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with MICU1: view

Variants for MICU1 Gene

Sequence variations from dbSNP and Humsavar for MICU1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs369915689 Pathogenic 72,477,173(+) ACTTG(C/T)CTGTT splice-donor-variant
rs754639936 Pathogenic 72,408,038(+) AGACC(C/G)TGCAA splice-acceptor-variant
rs777327250 Pathogenic 72,508,260(+) TTCCT(A/G)GGAAA intron-variant, nc-transcript-variant, reference, stop-gained, utr-variant-5-prime
rs1004256 -- 72,445,171(-) TCTGA(C/T)GTTGC intron-variant
rs1029207 -- 72,410,114(+) GGAAT(C/T)ATGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MICU1 Gene

Variant ID Type Subtype PubMed ID
nsv476601 CNV novel sequence insertion 20440878
nsv476199 CNV novel sequence insertion 20440878
nsv470964 CNV loss 18288195
nsv1137938 CNV deletion 24896259
nsv1127123 CNV deletion 24896259
esv3891858 CNV loss 25118596
esv3623799 CNV loss 21293372
esv3623797 CNV loss 21293372
esv3578974 CNV loss 25503493
esv3449716 CNV insertion 20981092
esv2554610 CNV insertion 19546169
esv1734966 CNV insertion 17803354

Variation tolerance for MICU1 Gene

Residual Variation Intolerance Score: 56.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.92; 35.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MICU1 Gene

Human Gene Mutation Database (HGMD)
MICU1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MICU1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MICU1 Gene

Disorders for MICU1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for MICU1 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
myopathy with extrapyramidal signs
  • proximal myopathy with extrapyramidal signs
fish allergy
  • allergy to fish
dermatitis
  • eczema
- elite association - COSMIC cancer census association via MalaCards
Search MICU1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

MICU1_HUMAN
  • Myopathy with extrapyramidal signs (MPXPS) [MIM:615673]: An autosomal recessive disorder characterized by early-onset proximal muscle weakness with a static course and moderately to grossly elevated serum creatine kinase levels accompanied by learning difficulties. Most patients develop subtle extrapyramidal motor signs that progress to a debilitating disorder of involuntary movement with variable features, including chorea, tremor, dystonic posturing and orofacial dyskinesia. Additional variable features include ataxia, microcephaly, ophthalmoplegia, ptosis, optic atrophy and axonal peripheral neuropathy. {ECO:0000269 PubMed:24336167}. Note=The disease is caused by mutations affecting the gene represented in this entry. The complex phenotype is due to alterations in mitochondrial calcium signaling characterized by increased mitochondrial Ca(2+) load (PubMed:24336167). {ECO:0000269 PubMed:24336167}.
  • Note=An homozygous partial MICU1 deletion is responsible for a disorder manifesting in childhood with fatigue, lethargy and muscle weakness. The disease is caused by mutations affecting the gene represented in this entry. {ECO:0000269 PubMed:27123478}.

Relevant External Links for MICU1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MICU1
genes like me logo Genes that share disorders with MICU1: view

No data available for Genatlas for MICU1 Gene

Publications for MICU1 Gene

  1. MICU1 encodes a mitochondrial EF hand protein required for Ca(2+) uptake. (PMID: 20693986) Perocchi F. … Mootha V.K. (Nature 2010) 2 3 4 64
  2. Isolation of cDNA clones coding for IgE autoantigens with serum IgE from atopic dermatitis patients. (PMID: 9806765) Natter S. … Valenta R. (FASEB J. 1998) 2 3 4 64
  3. Dual functions of a small regulatory subunit in the mitochondrial calcium uniporter complex. (PMID: 27099988) Tsai M.F. … Miller C. (Elife 2016) 3 4 64
  4. Functional roles of MICU1 and MICU2 in mitochondrial Ca(2+) uptake. (PMID: 26903221) Matesanz-Isabel J. … Alvarez J. (Biochim. Biophys. Acta 2016) 3 4 64
  5. Rearrangement of MICU1 multimers for activation of MCU is solely controlled by cytosolic Ca(2.). (PMID: 26489515) Waldeck-Weiermair M. … Graier W.F. (Sci. Rep. 2015) 3 4 64

Products for MICU1 Gene

Sources for MICU1 Gene

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