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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MICB Gene

protein-coding   GIFtS: 64
GCID: GC06P031465

MHC Class I Polypeptide-Related Sequence B

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
MHC Class I Polypeptide-Related Sequence B1 2     MHC Class I Mic-B Antigen2
MIC-B2 3     MHC Class I-Like Molecule PERB11.2-IMX2
PERB11.22 3     Stress Inducible Class I Homolog2
MHC Class I Chain-Related Protein B2     

External Ids:    HGNC: 70911   Entrez Gene: 42772   Ensembl: ENSG000002045167   OMIM: 6024365   UniProtKB: Q299803   

Export aliases for MICB gene to outside databases

Previous GC identifers: GC06P031519 GC06P031421 GC06P031233 GC06P031570 GC06P031574 GC06P031576 GC06P031252


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MICB Gene:
This gene encodes a heavily glycosylated protein which is a ligand for the NKG2D type II receptor. Binding of the
ligand activates the cytolytic response of natural killer (NK) cells, CD8 alphabeta T cells, and gammadelta T
cells which express the receptor. This protein is stress-induced and is similar to MHC class I molecules;
however, it does not associate with beta-2-microglobulin or bind peptides. (provided by RefSeq, Jul 2008)

GeneCards Summary for MICB Gene: 
MICB (MHC class I polypeptide-related sequence B) is a protein-coding gene. Diseases associated with MICB include behcet's disease, and relapsing-remitting multiple sclerosis, and among its related super-pathways are Immune System and Immune response Role of DAP12 receptors in NK cells. GO annotations related to this gene include natural killer cell lectin-like receptor binding. An important paralog of this gene is MICA.

UniProtKB/Swiss-Prot: MICB_HUMAN, Q29980
Function: Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized
by gamma delta T cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis

Gene Wiki entry for MICB Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NT_007592.15  NT_113891.2  NT_167244.1  NT_167245.1  NT_167247.1  NT_167248.1  NT_167249.1  
NC_018917.2  NT_167246.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MICB gene promoter:
         POU2F1   Sp1   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMICB promoter sequence
   Search SABiosciences Chromatin IP Primers for MICB

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MICB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p21.33   HGNC cytogenetic band: 6p21.3

MICB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MICB gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P031465:  view genomic region     (about GC identifiers)

Start:
31,462,658 bp from pter      End:
31,478,901 bp from pter
Size:
16,244 bases      Orientation:
plus strand

6/7 alternative locations (see all 7):
Chr6+,NT_167245 2,751,271-2,764,495      Chr6+,NT_167247 2,845,617-2,858,656      Chr6+,NT_167244 2,780,562-2,793,590     
Chr6+,NT_113891.2 2,975,524-2,988,570      Chr6+,NT_167248 2,759,574-2,772,598      Chr6+,NT_167246 2,816,315-2,821,820     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MICB_HUMAN, Q29980 (See protein sequence)
Recommended Name: MHC class I polypeptide-related sequence B precursor  
Size: 383 amino acids; 42646 Da
Subunit: Unlike classical MHC class I molecules, does not form a heterodimer with beta-2-microglobulin. Binds as a
monomer to a KLRK1/NKG2D homodimer. KLRK1 forms a complex with HCST/DAP10 in which KLRK1 binds MICB while HCST
acts as an adapter molecule which enables signal transduction. Receptor-ligand interaction induces clustering of
both proteins in ordered structures called immune synapses and also leads to their intercellular transfer. This
is associated with a reduction in the cytotoxicity of KLRK1-expressing cells. Binds to human cytomegalovirus
glycoprotein UL16 which causes sequestration of MICB in the endoplasmic reticulum and increases resistance to
KLRK1-mediated cytotoxicity
Subcellular location: Cell membrane; Single-pass type I membrane protein (By similarity). Note=Binding to human
cytomegalovirus glycoprotein UL16 causes sequestration in the endoplasmic reticulum
2 PDB 3D structures from and Proteopedia for MICB:
1JE6 (3D)        2WY3 (3D)    
Secondary accessions: A6NP85 B0UZ10 O14499 O14500 O19798 O19799 O19800 O19801 O19802 O19803
O78099 O78100 O78101 O78102 O78103 O78104 P79525 P79541 Q5GR31 Q5GR37 Q5GR41 Q5GR42 Q5GR43
Q5GR44 Q5GR46 Q5GR48 Q5RIY6 Q5SSK1 Q5ST25 Q7JK51 Q7YQ89 Q9MY18 Q9MY19 Q9MY20 Q9UBH4 Q9UBZ8
Q9UEJ0
Alternative splicing: 3 isoforms:  Q29980-1   Q29980-2   Q29980-3   (A GC to AG nucleotide substitution in intron 1 generates a splice junction which gives rise to an additional exon between exons 1 and 2. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for MICB: NX_Q29980

Explore proteomics data for MICB at MOPED 

Post-translational modifications:

  • UniProtKB: Proteolytically cleaved and released from the cell surface of tumor cells
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q29980

  • MICB Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MICB Protein Expression
    REFSEQ proteins: NP_005922.2  
    ENSEMBL proteins: 
     ENSP00000382103   ENSP00000252229   ENSP00000395391   ENSP00000442345  
    Reactome Protein details: Q29980
    Human Recombinant Protein Products for MICB: 
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    Browse recombinant and purified proteins available from Enzo Life Sciences
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    OriGene Protein Over-expression Lysate for MICB
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    GenScript Purified and Recombinant Proteins for MICB
    Novus Biologicals MICB Proteins
    Novus Biologicals MICB Lysates
    Sino Biological Recombinant Protein for MICB
    Sino Biological Cell Lysate for MICB 
    ProSpec Recombinant Protein for MICB
    Cloud-Clone Corp. Proteins for MICB 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0009986cell surface ISS--
    GO:0016021integral to membrane IEA--
    GO:0042612MHC class I protein complex ----

    MICB for ontologies           About GeneDecksing



    MICB Antibody Products: 
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    Novus Biologicals MICB Antibodies
    Abcam antibodies for MICB
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    ThermoFisher Antibodies for MICB
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    Assay Products for MICB: 
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    GenScript Custom Assay Services for MICB
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MICB 
    Cloud-Clone Corp. CLIAs for MICB


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    C1SET: Immunoglobulin superfamily / C1-set domain containing

    5/6 InterPro protein domains (see all 6):
     IPR011162 MHC_I/II-like_Ag-recog
     IPR013783 Ig-like_fold
     IPR003597 Ig_C1-set
     IPR007110 Ig-like_dom
     IPR011161 MHC_I-like_Ag-recog

    Graphical View of Domain Structure for InterPro Entry Q29980

    ProtoNet protein and cluster: Q29980

    1 Blocks protein domain: IPB003597 Immunoglobulin C-type

    UniProtKB/Swiss-Prot: MICB_HUMAN, Q29980
    Similarity: Belongs to the MHC class I family. MIC subfamily
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain


    MICB for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MICB_HUMAN, Q29980
    Function: Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized
    by gamma delta T cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis
    Induction: By heat shock, oxidative stress, retinoic acid, IFN-alpha and the DNA methyltransferase inhibitor
    5-aza-2'-deoxycytidine. Induction by IFN-alpha is impaired in patients with chronic hepatitis C virus infection.
    Down-regulated by human cytomegalovirus UL112 microRNA during viral infection which leads to decreased binding of
    KLRK1/NKG2D and reduced killing by natural killer cells

         Genatlas biochemistry entry for MICB:
    MHC class I,chain-related gene B,preferentially expressed in fibroblast and epithelial cell

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003823antigen binding IBA--
    GO:0005515protein binding ----
    GO:0046703natural killer cell lectin-like receptor binding IDA11491531
         
    MICB for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for MICB:
     Decreased viability with pacli  Increased G2M DNA content  Increased number of mitotic ce 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for MICB 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MICB

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MICB 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MICB 

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidMICB 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: MICB (NM_005931)
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                         Customized lentivirus expression plasmids for stable overexpression of MICB 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MICB


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MICB About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Immune System
    Immune System0.56
    Adaptive Immune System0.56
    2Immune response Fc epsilon RI pathway
    Natural killer cell mediated cytotoxicity0.31
    3Classical antibody-mediated complement activation
    Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell0.30

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    3        Reactome Pathways for MICB
        Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
    Adaptive Immune System
    Immune System


    1         Kegg Pathway  (Kegg details for MICB):
        Natural killer cell mediated cytotoxicity


    MICB for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MICB

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for MICB (Q299803 ENSP000002522294) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KLRK1P267183, ENSP000002406184I2D: score=2 STRING: ENSP00000240618
    KLRC4O439083, ENSP000003102164I2D: score=1 STRING: ENSP00000310216
    About this table

    Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001913T cell mediated cytotoxicity IBA--
    GO:0002429immune response-activating cell surface receptor signaling pathway IDA11491531
    GO:0006955immune response ----
    GO:0006979response to oxidative stress IDA11287116
    GO:0009408response to heat IDA9497295

    MICB for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MICB for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MICB

    1 PharmGKB related drug/compound annotation for MICB gene    About this table
    Drug/compound PharmGKB Annotation
    allopurinolCA  

    Search CenterWatch for drugs/clinical trials and news about MICB

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MICB gene: 
    NM_005931.3  

    Unigene Cluster for MICB:

    MHC class I polypeptide-related sequence B
    Hs.731446  [show with all ESTs]
    Unigene Representative Sequence: NM_005931
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000399150(uc003nto.4) ENST00000252229(uc011dnm.2 uc003ntn.4)
    ENST00000494577 ENST00000427115 ENST00000538442(uc021yuq.1)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Inhib. RNA
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MICB (NM_005931)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MICB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MICB
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MICB

    Additional mRNA sequence: 

    AF021221.1 AF021222.1 AF021223.1 AF021224.1 AF021225.1 AF021226.1 AK291927.1 AK300791.1 
    AK303655.1 AK314228.1 AY885251.1 BC044218.1 GU235997.1 U95729.1 U95730.1 U95731.1 
    U95732.1 U95733.1 U95734.1 X91625.1 

    19 DOTS entries:

    DT.100773245  DT.95085360  DT.121310550  DT.121310783  DT.408185  DT.97844162  DT.100813116  DT.121310518 
    DT.121310373  DT.100780405  DT.100765049  DT.100813115  DT.121310192  DT.121310691  DT.40210949  DT.40295476 
    DT.95280037  DT.97795556  DT.97798115 

    24/43 AceView cDNA sequences (see all 43):

    BQ056005 AF021224 U95734 BX462489 BV204449 AW851096 U95733 AF021222 
    BU182708 BI868468 U95732 NM_005931 AF021223 BP358327 X91625 BU958824 
    AF021221 H69835 U95731 AF021226 U95729 BQ928510 BQ430350 BC044218 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MICB expression in normal human tissues (normalized intensities)      MICB embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGTGAACTTT
    MICB Expression
    About this image


    MICB expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Smooth Muscle (Muscoskeletal System)
             Human Pulmonary Artery Smooth Muscle Cells (HPASMC)   
     
     Lung (Muscoskeletal System)
             Human Pulmonary Artery Smooth Muscle Cells (HPASMC)   
     
     Inner Cell Mass (Early Embryonic Tissues)
             Line H9 (WA09)

    See MICB Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MICB

    SOURCE GeneReport for Unigene cluster: Hs.731446

    UniProtKB/Swiss-Prot: MICB_HUMAN, Q29980
    Tissue specificity: Widely expressed with the exception of the central nervous system where it is absent.
    Expressed in many, but not all, epithelial tumors of lung, breast, kidney, ovary, prostate and colon. In
    hepatocellular carcinomas, expressed in tumor cells but not in surrounding non-cancerous tissue

        SABiosciences Expression via Pathway-Focused PCR Array including MICB: 
              T-cell & B-cell Activation in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MICB

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for MICB gene from 4/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mill21 , 5 MHC I like leukocyte 21, 5 54.48(n)1
    36.56(a)1
      7 (9.35 cM)5
    2438641  NM_153760.21  NP_715641.11 
     188399665 
    chicken
    (Gallus gallus)
    Aves --
    --
    28(a)
    1 → many
    AADN03014659.1(517-1002)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    21(a)
    possible ortholog
    GL343777.1(59223-67524)
    zebrafish
    (Danio rerio)
    Actinopterygii BX572619.16
    CR339041.26
    (see all 11)
    Uncharacterized protein
    (see all 11)
    20(a)
    19(a)
    (see all 11)
    many ↔ many
    many ↔ many
    (see all 11)
    25(11082589-11085195)
    25(11300140-11301469)


    ENSEMBL Gene Tree for MICB (if available)
    TreeFam Gene Tree for MICB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MICB gene
    MICA2  AZGP12  
    18/60 SIMAP similar genes for MICB using alignment to 10 protein entries:     MICB_HUMAN (see all proteins) (see all similar genes):
    MICA    HLA-MICA    DKFZp762B162    PERB11.1    HLA-A*0201V3    HFE
    Cw    HLA-A*33    HLA-A*02    HLA-A*0226    HLA-A*31    HLA-A24AK
    HLA-Cw*    HLA-Cw*15P    HLA-H    MHC class I HLA-A    HLA-DMB    HLA-Cw3

    MICB for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for MICB
    PGOHUM00000243132 PGOHUM00000243573


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: MICB_HUMAN, Q29980
    Polymorphism: The following alleles of MICB are known: MICB*001, MICB*002, MICB*003, MICB*004, MICB*005, MICB*006,
    MICB*007, MICB*008, MICB*009N, MICB*010, MICB*011, MICB*012, MICB*013, MICB*014, MICB*015, MICB*016, MICB*018,
    MICB*019, MICB*020, MICB*021N and MICB*022. MICB*009N and MICB*021N are null alleles which are not expressed. The
    sequence shown is that of MICB*001


    10/490 SNPs in MICB are shown (see all 490)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs69161871,2
    C,F,A,H--31463926(+) accacT/CgCCTA 2 -- us2k19Minor allele frequency- C:0.36NS EA NA WA 780
    rs1403050031,2
    C--31463956(+) ATGTGC/TGCTGG 2 -- us2k10--------
    rs25346781,2
    C,F,A,H--31463963(-) CTTGTC/ACCCAG 2 -- us2k16Minor allele frequency- A:0.17NA WA EA 364
    rs92815081,2
    C--31463985(+) GTAGA-/AAGA  
            
    GGCTT
    2 -- us2k10--------
    rs25346771,2
    C,F--31464026(-) ATGTGA/GATTCT 2 -- us2k17Minor allele frequency- G:0.17NA WA EA 366
    rs25346761,2
    C,F,A,H--31464029(-) ggcatA/Gtgaat 2 -- us2k18Minor allele frequency- G:0.35WA NA CSA EA 367
    rs69163941,2
    C,F,A,H--31464050(+) tatcgT/Ctttaa 2 -- us2k125Minor allele frequency- C:0.38NS EA NA WA 3350
    rs412938601,2
    C,F--31464091(+) CACAAG/AGTTGT 2 -- us2k11Minor allele frequency- A:0.04NA 120
    rs1130136841,2
    C--31464188(+) GCCCAG/AGCTGG 2 -- us2k11Minor allele frequency- A:0.50NA 2
    rs92673661,2
    C--31464229(+) AGCTCC/TGCCTC 2 -- us2k11Minor allele frequency- T:0.50NA 2

    HapMap Linkage Disequilibrium report for MICB (31462658 - 31478901 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/13 variations for MICB (see all 13):    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv1042e201CNV Deletion23290073
    esv2731822CNV Deletion23290073
    nsv462869CNV Loss19166990
    dgv215e55CNV Loss17911159
    nsv10821CNV Loss18304495
    nsv884412CNV Gain21882294
    dgv213e55CNV Gain17911159
    dgv6580n71CNV Gain21882294
    nsv884413CNV Gain21882294
    essv13266CNV CNV17122850


    Human Gene Mutation Database (HGMD): MICB

    Locus Specific Mutation Databases (LSDB): MICB
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602436    OMIM disorders: --

    UniProtKB/Swiss-Prot: MICB_HUMAN, Q29980
  • Rheumatoid arthritis (RA) [MIM:180300]: An inflammatory disease with autoimmune features and a complex
    genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial
    membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal
    tissues, and by atrophy and rarefaction of bony structures. Note=Disease susceptibility is associated with
    variations affecting the gene represented in this entry. The MICB*004 allele is associated with rheumatoid
    arthritis
  • Note=Genetic variation in MICB is associated with cytomegalovirus and herpes simplex virus I
    seropositivity and this may be associated with schizophrenia risk

  • 20/58 diseases for MICB (see all 58):    About MalaCards
    behcet's disease    relapsing-remitting multiple sclerosis    primary sclerosing cholangitis    sclerosing cholangitis
    celiac disease    rubella    cholangitis    malt lymphoma
    addison's disease    neurologic diseases    psoriatic arthritis    stomatitis
    skin cancer    leprosy    ulcerative colitis    b-cell chronic lymphocytic leukemia
    inflammatory bowel disease    multiple sclerosis    colon adenocarcinoma    dilated cardiomyopathy


    MICB for disorders           About GeneDecksing

    10/12 Novoseek inferred disease relationships for MICB gene (see all 12)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    behcet disease 45.1 1 9712354 (1)
    colitis ulcerative 24.3 5 11782275 (3), 19662431 (1), 18785505 (1)
    tumors 20.5 17 16698441 (3), 12714493 (1), 17510432 (1), 17557375 (1) (see all 9)
    celiac disease 19.7 3 16698444 (1), 15089901 (1)
    autoimmune diseases 19.5 5 19662431 (1), 12799463 (1), 17557375 (1)
    genetic susceptibility 18.9 2 11584356 (1), 16923796 (1)
    cancer 16 6 16698441 (1), 18505429 (1), 16866882 (1), 17181741 (1)
    colon carcinoma 14.5 4 11287116 (2), 12466900 (1)
    inflammatory bowel diseases 12.9 3 11782275 (2), 11584356 (1)
    virus infection 0 2 12799463 (1), 17641203 (1)

    Genetic Association Database (GAD): MICB
    Human Genome Epidemiology (HuGE) Navigator: MICB (31 documents)

    Export disorders for MICB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MICB gene, integrated from 9 sources (see all 181):
    (articles sorted by number of sources associating them with MICB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. MHC class I chain-related gene B (MICB) is associated with rheumatoid arthritis susceptibility. (PubMed id 17003176)1, 2, 4, 9 Lopez-Arbesu R.... Gonzalez S. (2007)
    2. Polymorphisms in MICB are associated with human herpes virus seropositivity and schizophrenia risk. (PubMed id 17561376)1, 2, 4 Shirts B.H.... Nimgaonkar V.L. (2007)
    3. Sequencing-based genotyping and association analysis of the MICA and MICB genes in type 1 diabetes. (PubMed id 18332098)1, 4, 9 Field S.F....Todd J.A. (2008)
    4. MHC class I chain-related gene B promoter polymorphisms and celiac disease. (PubMed id 16698444)1, 4, 9 Rodriguez-Rodero S....Lopez-Larrea C. (2006)
    5. Associations of MICB with cervical cancer in north-eastern Thais: identification of major histocompatibility complex class I chain-related gene B motifs influencing natural killer cell activation. (PubMed id 18505429)1, 4, 9 Jumnainsong A....Leelayuwat C. (2008)
    6. Release of MICB molecules by tumor cells: mechanism and soluble MICB in sera of cancer patients. (PubMed id 16698441)1, 2, 9 Salih H.R.... Steinle A. (2006)
    7. Study on the haplotypes of MICA and MICB microsatellite and HLA-B locus in the Guangzhou Han population. (PubMed id 15304009)1, 4, 9 Feng M.L....Qian K.C. (2004)
    8. [The study on the haplotype of MICA and MICB microsatellite locus in Guangzhou Han population.] (PubMed id 15640005)1, 4, 9 Feng M.L....Ji Y. (2004)
    9. Allelic variants of the human MHC class I chain-related B gene (MICB). (PubMed id 9321430)1, 2, 9 Ando H.... Inoko H. (1997)
    10. Alternatively spliced forms of MICA and MICB lacking exon 3 in a human cell line and evidence of presence of similar RNA in human peripheral blood mononuclear cells. (PubMed id 12466900)1, 2, 9 Zou Y. and Stastny P. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4277 HGNC: 7091 AceView: MICB Ensembl:ENSG00000204516 euGenes: HUgn4277
    ECgene: MICB Kegg: 4277 H-InvDB: MICB

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MICB Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MICB gene:
    Search GeneIP for patents involving MICB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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