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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MICB Gene

protein-coding   GIFtS: 62
GCID: GC06P031465

MHC class I polypeptide-related sequence B
 Explore 59 diseases affiliated with
MICB via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MICB    

Aliases
for MICB gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
MHC Class I Polypeptide-Related Sequence B1 2     MHC Class I Mic-B Antigen2
PERB11.21 2 3     MHC Class I-Like Molecule PERB11.2-IMX2
MIC-B2 3     Stress Inducible Class I Homolog2
MHC Class I Chain-Related Protein B2     

External Ids:    HGNC: 70911   Entrez Gene: 42772   Ensembl: ENSG000002045167   OMIM: 6024365   UniProtKB: Q299803   

Export aliases for MICB gene to outside databases

Previous GC identifers: GC06P031519 GC06P031421 GC06P031233 GC06P031570 GC06P031574 GC06P031576 GC06P031252


Summaries
for MICB gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for MICB:
This gene encodes a heavily glycosylated protein which is a ligand for the NKG2D type II receptor. Binding of the
ligand activates the cytolytic response of natural killer (NK) cells, CD8 alphabeta T cells, and gammadelta T cells
which express the receptor. This protein is stress-induced and is similar to MHC class I molecules; however, it does
not associate with beta-2-microglobulin or bind peptides. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: MICB_HUMAN, Q29980
Function: Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by
gamma delta T cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis

Gene Wiki entry for MICB


Genomic Views
for MICB gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_007592.15  NT_113891.2  NT_167244.1  NT_167245.1  NT_167246.1  NT_167247.1  
NT_167248.1  NT_167249.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MICB gene promoter:
         POU2F1   Sp1   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MICB promoter sequence
   Search SABiosciences Chromatin IP Primers for MICB

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MICB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p21.33   HGNC cytogenetic band: 6p21.3

MICB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MICB gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P031465:  view genomic region     (about GC identifiers)

Start:
 31,462,658 bp from pter      End:
 31,478,901 bp from pter
Size:
 16,244 bases      Orientation:
 plus strand

6/7 alternative locations (see all 7):
Chr6+,ALT_REF_LOCI_2 31,450,124-31,505,554      Chr6+,ALT_REF_LOCI_4 31,435,974-31,441,479      Chr6+,ALT_REF_LOCI_3 31,444,680-31,472,136     
Chr6+,ALT_REF_LOCI_5 31,457,040-31,470,079      Chr6+,ALT_REF_LOCI_1 31,473,968-31,498,493      Chr6+,ALT_REF_LOCI_6 31,456,185-31,504,782     

Proteins
for MICB gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MICB_HUMAN, Q29980 (See protein sequence)
Recommended Name: MHC class I polypeptide-related sequence B precursor  
Size: 383 amino acids; 42646 Da
Subunit: Unlike classical MHC class I molecules, does not form a heterodimer with beta-2-microglobulin. Binds as a
monomer to a KLRK1/NKG2D homodimer. KLRK1 forms a complex with HCST/DAP10 in which KLRK1 binds MICB while HCST acts as
an adapter molecule which enables signal transduction. Receptor-ligand interaction induces clustering of both proteins
in ordered structures called immune synapses and also leads to their intercellular transfer. This is associated with a
reduction in the cytotoxicity of KLRK1-expressing cells. Binds to human cytomegalovirus glycoprotein UL16 which causes
sequestration of MICB in the endoplasmic reticulum and increases resistance to KLRK1-mediated cytotoxicity
Subcellular location: Cell membrane; Single-pass type I membrane protein (By similarity). Note=Binding to human
cytomegalovirus glycoprotein UL16 causes sequestration in the endoplasmic reticulum
2 PDB 3D structures from and Proteopedia for MICB:
1JE6 (3D)        2WY3 (3D)    
Secondary accessions: A6NP85 B0UZ10 O14499 O14500 O19798 O19799 O19800 O19801 O19802 O19803 O78099
O78100 O78101 O78102 O78103 O78104 P79525 P79541 Q5GR31 Q5GR37 Q5GR41 Q5GR42 Q5GR43 Q5GR44 Q5GR46
Q5GR48 Q5RIY6 Q5SSK1 Q5ST25 Q7JK51 Q7YQ89 Q9MY18 Q9MY19 Q9MY20 Q9UBH4 Q9UBZ8 Q9UEJ0
Alternative splicing: 3 isoforms:  Q29980-1   Q29980-2   Q29980-3   (A GC to AG nucleotide substitution in intron 1 generates a splice junction which gives rise to an additional exon between exons 1 and 2. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for MICB: NX_Q29980

Post-translational modifications:

  • Proteolytically cleaved and released from the cell surface of tumor cells1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q29980

    • MICB Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_005922.2  
    ENSEMBL proteins: 
     ENSP00000382103   ENSP00000252229   ENSP00000395391   ENSP00000442345  
    Reactome Protein details: Q29980
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for MICB
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: MICB
    OriGene Protein Over-expression Lysate: MICB
    OriGene Custom Protein Services for MICB 
    GenScript Purified and Recombinant Proteins for MICB
    Novus Biologicals MICB Proteins
    Novus Biologicals MICB Lysates
    Sino Biological Recombinant Protein for MICB
    ProSpec Recombinant Protein for MICB
    Uscn Proteins for MICB

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane ISS--
    GO:0042612MHC class I protein complex IEA--


    MICB for ontologies           About GeneDecksing



    MICB Antibody Products: 
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    Novus Biologicals MICB Antibodies
    Search for Antibodies for MICB at Abcam  
    Uscn Antibodies for MICB
    Search ThermoFisher Antibodies for MICB

    Assay Products for MICB: 
    Browse Kits and Assays available from EMD Millipore
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    Uscn ELISAs and CLIAs for MICB

    Protein Domains /
    Families
    for MICB gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MICB for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR011162 MHC_I/II-like_Ag-recog
     IPR013783 Ig-like_fold
     IPR003597 Ig_C1-set
     IPR007110 Ig-like_dom
     IPR011161 MHC_I-like_Ag-recog

    Graphical View of Domain Structure for InterPro Entry Q29980

    ProtoNet protein and cluster: Q29980

    1 Blocks protein family: IPB003597 Immunoglobulin C-type

    UniProtKB/Swiss-Prot: MICB_HUMAN, Q29980
    Similarity: Belongs to the MHC class I family. MIC subfamily
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain


    Function
    for MICB gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: MICB_HUMAN, Q29980
    Function: Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by
    gamma delta T cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis
    Induction: By heat shock, oxidative stress, retinoic acid, IFN-alpha and the DNA methyltransferase inhibitor
    5-aza-2'-deoxycytidine. Induction by IFN-alpha is impaired in patients with chronic hepatitis C virus infection.
    Down-regulated by human cytomegalovirus UL112 microRNA during viral infection which leads to decreased binding of
    KLRK1/NKG2D and reduced killing by natural killer cells

         Genatlas biochemistry entry for MICB:
    MHC class I,chain-related gene B,preferentially expressed in fibroblast and epithelial cell

    miRNA
    Products:            		 OriGene 3'-UTR Clone: MICB
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MICB
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate MICB
    SwitchGear 3'UTR luciferase reporter plasmid: MICB 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MICB (see all 4)
    OriGene shRNA RFP: MICB
    OriGene siRNA: MICB
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MICB

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for MICB

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MICB (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MICB (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: MICB (NM_005931)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MICB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MICB 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for MICB
    Search LifeMap BioReagents cell lines for MICB

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MICB

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0046703natural killer cell lectin-like receptor binding IDA11491531


    MICB for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for MICB:
     Decreased viability with pacli  Increased G2M DNA content  Increased number of mitotic ce 


    Pathways & Interactions
    for MICB gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Immune System
    		Immune System1.00
    		Adaptive Immune System0.59
    2Natural killer cell mediated cytotoxicity
    		Natural killer cell mediated cytotoxicity1.00
    3Cleavage of Alpha-1-Microglobulin
    		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell0.30

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    3        Reactome Pathways for MICB
        Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
    Adaptive Immune System
    Immune System


    1         Kegg Pathway  (Kegg details for MICB):
        Natural killer cell mediated cytotoxicity


    MICB for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MICB

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for MICB (Q299803 ENSP000002522294) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KLRK1P267183, ENSP000002406184I2D: score=2 STRING: ENSP00000240618
    KLRC4O439083, ENSP000003102164I2D: score=1 STRING: ENSP00000310216
    About this table

    Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002429immune response-activating cell surface receptor signaling pathway IDA11491531
    GO:0006955immune response IEA--
    GO:0006979response to oxidative stress IDA11287116
    GO:0009408response to heat IDA9497295
    GO:0019048virus-host interaction IEA--


    MICB for ontologies           About GeneDecksing



    Drugs & Compounds
    for MICB gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MICB for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MICB
    1 PharmGKB related drug/compound annotation for MICB gene
    Drug/compound PharmGKB Annotation
    allopurinolCA  
    About this table

    Search CenterWatch for drugs/clinical trials and news about MICB 

    Transcripts
    for MICB gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MICB gene: 
    NM_005931.3  

    Unigene Cluster for MICB:

    MHC class I polypeptide-related sequence B
    Hs.731446  [show with all ESTs]
    Unigene Representative Sequence: NM_005931
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000399150(uc003nto.4) ENST00000252229(uc011dnm.2 uc003ntn.4)
    ENST00000494577 ENST00000427115 ENST00000538442(uc021yuq.1)

    miRNA
    Products:             		 OriGene 3'-UTR Clone: MICB
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MICB
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate MICB
    SwitchGear 3'UTR luciferase reporter plasmid: MICB 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MICB (see all 4)
    OriGene shRNA RFP: MICB
    OriGene siRNA: MICB
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MICB
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MICB (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: MICB (NM_005931)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MICB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MICB 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MICB
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MICB
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MICB
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MICB

    Additional cDNA sequence: 

    AF021221.1 AF021222.1 AF021223.1 AF021224.1 AF021225.1 AF021226.1 AK291927.1 AK300791.1 
    AK303655.1 AK314228.1 AY885251.1 BC044218.1 GU235997.1 U95729.1 U95730.1 U95731.1 
    U95732.1 U95733.1 U95734.1 X91625.1 

    19 DOTS entries:

    DT.100773245  DT.95085360  DT.121310550  DT.121310783  DT.408185  DT.97844162  DT.100813116  DT.121310518 
    DT.121310373  DT.100780405  DT.100765049  DT.100813115  DT.121310192  DT.121310691  DT.40210949  DT.40295476 
    DT.95280037  DT.97795556  DT.97798115 

    24/43 AceView cDNA sequences (see all 43):

    AF021224 BX462489 U95734 BQ056005 U95732 AF021223 X91625 AF021226 
    BP358327 U95731 BV200700 BV204449 AF021222 BI868468 AW851096 BC044218 
    BQ928510 BQ688381 AF021225 H69835 BU182708 BP340573 NM_005931 BG118546 

    GeneLoc Exon Structure


    Expression
    for MICB gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MICB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGTGAACTTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See MICB Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MICB

    SOURCE GeneReport for Unigene cluster: Hs.731446

    UniProtKB/Swiss-Prot: MICB_HUMAN, Q29980
    Tissue specificity: Widely expressed with the exception of the central nervous system where it is absent. Expressed in
    many, but not all, epithelial tumors of lung, breast, kidney, ovary, prostate and colon. In hepatocellular carcinomas,
    expressed in tumor cells but not in surrounding non-cancerous tissue

        SABiosciences Expression via Pathway-Focused PCR Array including MICB: 
              T-cell & B-cell Activation in human mouse rat

    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MICB
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MICB

    Orthologs
    for MICB gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for MICB gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves F1NM79_CHICK6
    --
    (see all 15)    		 --
    		 28(a)
    28(a)
    (see all 15)    		 many ↔ many
    many ↔ many
    (see all 15)    		 16(40458-41204)
    16(204323-205564)
    lizard
    (Anolis carolinensis)    		 Reptilia --
    --
    (see all 25)    		 --
    		 31(a)
    30(a)
    (see all 25)    		 many ↔ many
    many ↔ many
    (see all 25)    		 AAWZ02040156(3915-5955)
    AAWZ02039289(783-2823)
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc:1366146
    si:ch211-287j19.66
    (see all 7)    		 si:ch211-287j19.6
    (see all 7)    		 19(a)
    18(a)
    (see all 7)    		 many ↔ many
    many ↔ many
    (see all 7)    		 1(47637895-47648897)
    1(47613228-47619236)


    ENSEMBL Gene Tree for MICB (if available)
    TreeFam Gene Tree for MICB (if available) 

    Paralogs
    for MICB gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MICB gene
    MICA2  AZGP12  
    18/67 SIMAP similar genes for MICB using alignment to 18 protein entries:     MICB_HUMAN (see all proteins) (see all similar genes):
    MICA    DKFZp762B162    PERB11.1    HLA-A*0201V3    HFE    Cw
    HLA-A*33    HLA-A*02    HLA-A*0226    HLA-A24AK    HLA-Cw*    HLA-Cw*15P
    HLA-H    MHC class I HLA-A    HLA-F    HLA-DMB    HLA-Cw3    HLA

    MICB for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for MICB
    PGOHUM00000243132 PGOHUM00000243573


    Genomic Variants
    for MICB gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: MICB_HUMAN, Q29980
    Polymorphism: The following alleles of MICB are known: MICB*001, MICB*002, MICB*003, MICB*004, MICB*005, MICB*006,
    MICB*007, MICB*008, MICB*009N, MICB*010, MICB*011, MICB*012, MICB*013, MICB*014, MICB*015, MICB*016, MICB*018,
    MICB*019, MICB*020, MICB*021N and MICB*022. MICB*009N and MICB*021N are null alleles which are not expressed. The
    sequence shown is that of MICB*001


    10/443 NCBI SNPs in MICB are shown (see all 443)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 6 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs709902511,2
    		C--31258854(+) TTTTT-/TGAGAT 1 -- int11Minor allele frequency- T:0.00NA 2
    rs69161871,2
    		C,F,A,H,--31463926(+) ACCACT/CGCCTA 2 -- us2k19Minor allele frequency- C:0.36NS EA NA WA 780
    rs1403050031,2
    		--31463956(+) ATGTGC/TGCTGG 1 -- us2k10--------
    rs25346781,2
    		C,F,A,H,--31463963(-) CTTGTA/C/G/T 
                CCCAG     		2 -- us2k16NA WA EA 364
    rs106888291,2
    		C,--31463982(+) TTAGT-/AGAA  
                AGAGG     		2 -- us2k10--------
    rs92815081,2
    		C--31463985(+) GTAGA-/AAGA  
                GGCTT     		2 -- us2k10--------
    rs25346771,2
    		C,F,--31464026(-) ATGTGA/GATTCT 2 -- us2k17Minor allele frequency- G:0.17NA WA EA 366
    rs25346761,2
    		C,F,A,H,--31464029(-) ggcatA/Gtgaat 2 -- us2k18Minor allele frequency- G:0.35WA NA CSA EA 367
    rs69163941,2
    		C,F,A,H,--31464050(+) tatcgT/Ctttaa 2 -- us2k125Minor allele frequency- C:0.38NS EA NA WA 3350
    rs412938601,2
    		C,F,--31464091(+) CACAAG/AGTTGT 2 -- us2k11Minor allele frequency- A:0.04NA 120

    HapMap Linkage Disequilibrium report for MICB (31462658 - 31478901 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 5 variations for MICB
         5 CNVs: 2625 32783 9033 3601 8510
    Human Gene Mutation Database (HGMD): MICB

    Locus Specific Mutation Databases (LSDB): MICB

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MICB
    DNA2.0 Custom Variant and Variant Library Synthesis for MICB

    Disorders / Diseases
    for MICB gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MICB for disorders           About GeneDecksing

    OMIM gene information: 602436    OMIM disorders: --

    UniProtKB/Swiss-Prot: MICB_HUMAN, Q29980
  • Genetic variations in MICA are a cause of susceptibility to rheumatoid arthritis (RA) [MIM:180300]. It is a
    • systemic inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the
    joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread
    fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony
    structures. Note=The MICB*004 allele is associated with rheumatoid arthritis
  • Note=Genetic variation in MICB is associated with cytomegalovirus and herpes simplex virus I seropositivity
    • and this may be associated with schizophrenia risk

    20/59 diseases for MICB (see all 59):    About MalaCards
    relapsing-remitting multiple sclerosis    sclerosing cholangitis    primary sclerosing cholangitis    inflammatory bowel disease
    dengue shock syndrome    cholangitis    rheumatoid arthritis    oral squamous cell carcinoma
    multiple sclerosis    systemic lupus erythematosus    malt lymphoma    behcet's disease
    squamous cell carcinoma    lupus erythematosus    celiac disease    psoriatic arthritis
    chronic lymphocytic leukemia    dilated cardiomyopathy    herpes simplex    lymphocytic leukemia

    10/12 Novoseek disease relationships for MICB gene (see all 12)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    behcet disease 45.1 1 9712354 (1)
    colitis ulcerative 24.3 5 11782275 (3), 19662431 (1), 18785505 (1)
    tumors 20.5 17 16698441 (3), 12714493 (1), 17510432 (1), 17557375 (1) (see all 9)
    celiac disease 19.7 3 16698444 (1), 15089901 (1)
    autoimmune diseases 19.5 5 19662431 (1), 12799463 (1), 17557375 (1)
    genetic susceptibility 18.9 2 11584356 (1), 16923796 (1)
    cancer 16 6 16698441 (1), 18505429 (1), 16866882 (1), 17181741 (1)
    colon carcinoma 14.5 4 11287116 (2), 12466900 (1)
    inflammatory bowel diseases 12.9 3 11782275 (2), 11584356 (1)
    virus infection 0 2 12799463 (1), 17641203 (1)

    Genetic Association Database (GAD): MICB
    Human Genome Epidemiology (HuGE) Navigator: MICB (31 documents)

    Export disorders for MICB gene to outside databases

    Publications
    for MICB gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MICB gene, integrated from 9 sources (see all 169):
    (articles sorted by number of sources associating them with MICB)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Release of MICB molecules by tumor cells: mechanism and soluble MICB in sera of cancer patients. (PubMed id 16698441)1, 2, 9 Salih H.R.... Steinle A. (2006)
    2. Study on the haplotypes of MICA and MICB microsatellite and HLA-B locus in the Guangzhou Han population. (PubMed id 15304009)1, 4, 9 Feng M.L....Qian K.C. (2004)
    3. [The study on the haplotype of MICA and MICB microsatellite locus in Guangzhou Han population.] (PubMed id 15640005)1, 4, 9 Feng M.L....Ji Y. (2004)
    4. Allelic variants of the human MHC class I chain-related B gene (MICB). (PubMed id 9321430)1, 2, 9 Ando H.... Inoko H. (1997)
    5. MHC class I chain-related gene B (MICB) is associated with rheumatoid arthritis susceptibility. (PubMed id 17003176)1, 2, 9 Lopez-Arbesu R.... Gonzalez S. (2007)
    6. Alternatively spliced forms of MICA and MICB lacking exon 3 in a human cell line and evidence of presence of similar RNA in human peripheral blood mononuclear cells. (PubMed id 12466900)1, 2, 9 Zou Y. and Stastny P. (2002)
    7. SSOP reveals three novel MICB alleles. (PubMed id 10746790)1, 2, 9 Fischer G.... Madrigal J.A. (2000)
    8. [The polymorphism distributions of MICA and MICB microsatellite in Guangdong Han population] (PubMed id 15192843)1, 4, 9 Feng M.L....Guo X.J. (2004)
    9. Sequencing-based typing reveals six novel MHC class I chain-related gene B (MICB) alleles. (PubMed id 9694358)1, 2, 9 Visser C.J.... Charron D. (1998)
    10. Alu polymorphism within the MICB gene and association with HLA-B alleles. (PubMed id 11862397)1, 4, 9 Kulski J.K....Inoko H. (2002)

    External Searches for MICB gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
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    Genome Databases showing MICB gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4277 HGNC: 7091 AceView: MICB Ensembl:ENSG00000204516 euGenes: HUgn4277
    ECgene: MICB Kegg: 4277 H-InvDB: MICB

    Other Databases showing MICB gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing MICB gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MICB Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for MICB gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MICB gene:
    Search GeneIP for patents involving MICB

    GeneCards and IP:
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