Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MICB Gene

Aliases for MICB Gene

  • MHC Class I Polypeptide-Related Sequence B 2 3
  • PERB11.2 3 4
  • MHC Class I-Like Molecule PERB11.2-IMX 3
  • MHC Class I Chain-Related Protein B 3
  • Stress Inducible Class I Homolog 3
  • MHC Class I Mic-B Antigen 3
  • MIC-B 4

External Ids for MICB Gene

Previous GeneCards Identifiers for MICB Gene

  • GC06P031519
  • GC06P031421
  • GC06P031233
  • GC06P031570
  • GC06P031574
  • GC06P031576
  • GC06P031252

Summaries for MICB Gene

Entrez Gene Summary for MICB Gene

  • This gene encodes a heavily glycosylated protein which is a ligand for the NKG2D type II receptor. Binding of the ligand activates the cytolytic response of natural killer (NK) cells, CD8 alphabeta T cells, and gammadelta T cells which express the receptor. This protein is stress-induced and is similar to MHC class I molecules; however, it does not associate with beta-2-microglobulin or bind peptides. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

GeneCards Summary for MICB Gene

MICB (MHC Class I Polypeptide-Related Sequence B) is a Protein Coding gene. Diseases associated with MICB include dengue shock syndrome and behcet's disease. Among its related pathways are Class I MHC mediated antigen processing and presentation and Immune response Role of DAP12 receptors in NK cells. GO annotations related to this gene include antigen binding and natural killer cell lectin-like receptor binding. An important paralog of this gene is MICA.

UniProtKB/Swiss-Prot for MICB Gene

  • Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis.

Gene Wiki entry for MICB Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MICB Gene

Genomics for MICB Gene

Regulatory Elements for MICB Gene

Genomic Location for MICB Gene

31,494,881 bp from pter
31,511,124 bp from pter
16,244 bases
Plus strand

Genomic View for MICB Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MICB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for MICB Gene

  • Protein details for MICB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    MHC class I polypeptide-related sequence B
    Protein Accession:
    Secondary Accessions:
    • A2AC57
    • A6NP85
    • B0UZ10
    • B2RAK2
    • O14499
    • O14500
    • O19798
    • O19799
    • O19800
    • O19801
    • O19802
    • O19803
    • O78099
    • O78100
    • O78101
    • O78102
    • O78103
    • O78104
    • P79525
    • P79541
    • Q5GR31
    • Q5GR37
    • Q5GR41
    • Q5GR42
    • Q5GR43
    • Q5GR44
    • Q5GR46
    • Q5GR48
    • Q5RIY6
    • Q5SSK1
    • Q5ST25
    • Q7JK51
    • Q7YQ89
    • Q861E6
    • Q9MY18
    • Q9MY19
    • Q9MY20
    • Q9UBH4
    • Q9UBZ8
    • Q9UEJ0

    Protein attributes for MICB Gene

    383 amino acids
    Molecular mass:
    42646 Da
    Quaternary structure:
    • Unlike classical MHC class I molecules, does not form a heterodimer with beta-2-microglobulin. Binds as a monomer to a KLRK1/NKG2D homodimer. KLRK1 forms a complex with HCST/DAP10 in which KLRK1 binds MICB while HCST acts as an adapter molecule which enables signal transduction. Receptor-ligand interaction induces clustering of both proteins in ordered structures called immune synapses and also leads to their intercellular transfer. This is associated with a reduction in the cytotoxicity of KLRK1-expressing cells. Binds to human cytomegalovirus glycoprotein UL16 which causes sequestration of MICB in the endoplasmic reticulum and increases resistance to KLRK1-mediated cytotoxicity.

    Three dimensional structures from OCA and Proteopedia for MICB Gene

    Alternative splice isoforms for MICB Gene


neXtProt entry for MICB Gene

Proteomics data for MICB Gene at MOPED

Post-translational modifications for MICB Gene

  • Proteolytically cleaved and released from the cell surface of tumor cells.
  • Ubiquitination at Lys196
  • Glycosylation at Asn164, Asn210, Asn220, and Asn261
  • Modification sites at PhosphoSitePlus

Other Protein References for MICB Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for MICB Gene

Domains for MICB Gene

Gene Families for MICB Gene

  • C1SET :Immunoglobulin superfamily / C1-set domain containing

Graphical View of Domain Structure for InterPro Entry



  • Q29980
  • Contains 1 Ig-like C1-type (immunoglobulin-like) domain.
  • Belongs to the MHC class I family. MIC subfamily.
genes like me logo Genes that share domains with MICB: view

Function for MICB Gene

Molecular function for MICB Gene

GENATLAS Biochemistry: MHC class I,chain-related gene B,preferentially expressed in fibroblast and epithelial cell
UniProtKB/Swiss-Prot Function: Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis.
UniProtKB/Swiss-Prot Induction: By heat shock, oxidative stress, retinoic acid, IFN-alpha and the DNA methyltransferase inhibitor 5-aza-2-deoxycytidine. Induction by IFN-alpha is impaired in patients with chronic hepatitis C virus infection. Down-regulated by human cytomegalovirus UL112 microRNA during viral infection which leads to decreased binding of KLRK1/NKG2D and reduced killing by natural killer cells.

Gene Ontology (GO) - Molecular Function for MICB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding IBA --
GO:0005515 protein binding --
GO:0030881 NOT beta-2-microglobulin binding IBA --
GO:0046703 natural killer cell lectin-like receptor binding IDA 11491531
genes like me logo Genes that share ontologies with MICB: view

Phenotypes for MICB Gene

genes like me logo Genes that share phenotypes with MICB: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MICB Gene

Localization for MICB Gene

Subcellular locations from UniProtKB/Swiss-Prot for MICB Gene

Cell membrane; Single-pass type I membrane protein. Note=Binding to human cytomegalovirus glycoprotein UL16 causes sequestration in the endoplasmic reticulum. {ECO:0000250 UniProtKB:Q29983, ECO:0000269 PubMed:12782710}.

Subcellular locations from

Jensen Localization Image for MICB Gene COMPARTMENTS Subcellular localization image for MICB gene
Compartment Confidence
plasma membrane 5
extracellular 2

Gene Ontology (GO) - Cellular Components for MICB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0009986 cell surface ISS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MICB: view

Pathways for MICB Gene

genes like me logo Genes that share pathways with MICB: view

Pathways by source for MICB Gene

Interacting Proteins for MICB Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000252229 Q29980-MICB_HUMAN for MICB Gene via STRING I2D

Gene Ontology (GO) - Biological Process for MICB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001913 T cell mediated cytotoxicity IBA --
GO:0002429 immune response-activating cell surface receptor signaling pathway IDA 11491531
GO:0006955 immune response --
GO:0006979 response to oxidative stress IDA 11287116
GO:0009408 response to heat IDA 9497295
genes like me logo Genes that share ontologies with MICB: view

Transcripts for MICB Gene

Unigene Clusters for MICB Gene

MHC class I polypeptide-related sequence B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MICB Gene

No ASD Table

Relevant External Links for MICB Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MICB Gene

mRNA expression in normal human tissues for MICB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MICB Gene

This gene is overexpressed in Whole Blood (8.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MICB Gene

SOURCE GeneReport for Unigene cluster for MICB Gene Hs.731446

mRNA Expression by UniProt/SwissProt for MICB Gene

Tissue specificity: Widely expressed with the exception of the central nervous system where it is absent. Expressed in many, but not all, epithelial tumors of lung, breast, kidney, ovary, prostate and colon. In hepatocellular carcinomas, expressed in tumor cells but not in surrounding non-cancerous tissue.
genes like me logo Genes that share expressions with MICB: view

Orthologs for MICB Gene

This gene was present in the common ancestor of chordates.

Orthologs for MICB Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MICB 35
  • 93.98 (n)
  • 88.48 (a)
  • 89 (a)
(Bos Taurus)
Mammalia -- 36
  • 46 (a)
MIC1 35
  • 70.74 (n)
  • 53.05 (a)
(Mus musculus)
Mammalia Mill2 35
  • 56.11 (n)
  • 38.22 (a)
Mill2 16
Mill2 36
  • 28 (a)
(Monodelphis domestica)
Mammalia MILL-LIKE 36
  • 25 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 22 (a)
-- 36
  • 26 (a)
-- 36
  • 17 (a)
-- 36
  • 20 (a)
-- 36
  • 19 (a)
-- 36
  • 17 (a)
-- 36
  • 17 (a)
-- 36
  • 20 (a)
-- 36
  • 22 (a)
(Rattus norvegicus)
Mammalia Micb 35
  • 53.24 (n)
  • 33.79 (a)
(Gallus gallus)
Aves -- 36
  • 25 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 21 (a)
(Danio rerio)
Actinopterygii arpc1a 36
  • 18 (a)
BX572619.1 36
  • 19 (a)
BX572619.2 36
  • 19 (a)
BX572619.3 36
  • 19 (a)
BX682558.1 36
  • 19 (a)
CABZ01031753.1 36
  • 17 (a)
CABZ01031754.1 36
  • 17 (a)
CR339041.1 36
  • 19 (a)
CR339041.2 36
  • 17 (a)
CU571323.1 36
  • 17 (a)
DARE-ZE*0601 36
  • 18 (a)
mhc1uba 36
  • 20 (a)
mhc1uca 36
  • 20 (a)
mhc1zaa 36
  • 17 (a)
mhc1zaa 36
  • 17 (a)
mhc1zba 36
  • 17 (a)
mhc1zca 36
  • 20 (a)
mhc1zea 36
  • 19 (a)
mhc1zfa 36
  • 19 (a)
si:ch211-147g22.1 36
  • 19 (a)
si:ch211-147g22.2 36
  • 18 (a)
si:ch211-147g22.3 36
  • 19 (a)
si:ch211-147g22.4 36
  • 23 (a)
si:dkey-52p2.4 36
  • 16 (a)
si:dkey-52p2.6 36
  • 18 (a)
si:dkey-52p2.7 36
  • 20 (a)
zgc:113060 36
  • 14 (a)
Species with no ortholog for MICB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MICB Gene

Gene Tree for MICB (if available)
Gene Tree for MICB (if available)

Paralogs for MICB Gene

Paralogs for MICB Gene Pseudogenes for MICB Gene

genes like me logo Genes that share paralogs with MICB: view

Variants for MICB Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for MICB Gene

The following alleles of MICB are known: MICB*001, MICB*002, MICB*003, MICB*004, MICB*005, MICB*006, MICB*007, MICB*008, MICB*009N, MICB*010, MICB*011, MICB*012, MICB*013, MICB*014, MICB*015, MICB*016, MICB*018, MICB*019, MICB*020, MICB*021N and MICB*022. MICB*009N and MICB*021N are null alleles which are not expressed. The sequence shown is that of MICB*001.

Sequence variations from dbSNP and Humsavar for MICB Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs1051788 -, - 31,506,223(+) ACTAC(A/C/G)ATGGG missense, reference, intron-variant
rs1065075 - 31,505,784(+) GAGCT(A/G)AGACC reference, missense
rs1065076 - 31,509,904(+) AGGGC(A/G)CCTAG reference, missense
rs2240858 -- 31,505,736(-) CCTGC(A/G)TTTCT reference, missense
rs2242955 -- 31,506,503(+) TGTCC(A/G)GGGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MICB Gene

Variant ID Type Subtype PubMed ID
esv690 CNV CNV 17122850
dgv1042e201 CNV Deletion 23290073
dgv1921e1 CNV Complex 17122850
dgv213e55 CNV Gain 17911159
essv13266 CNV CNV 17122850
esv2731822 CNV Deletion 23290073
dgv215e55 CNV Loss 17911159
nsv10821 CNV Loss 18304495
nsv884412 CNV Gain 21882294
nsv884413 CNV Gain 21882294
dgv6580n71 CNV Gain 21882294
dgv1927e1 CNV Complex 17122850
nsv462869 CNV Loss 19166990

Relevant External Links for MICB Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)
Locus Specific Mutation Databases (LSDB)

Disorders for MICB Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for MICB Gene including...

Search for MICB Gene in MalaCards »


  • Rheumatoid arthritis (RA) [MIM:180300]: An inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. {ECO:0000269 PubMed:17003176}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. The MICB*004 allele is associated with rheumatoid arthritis.
  • Note=Genetic variation in MICB is associated with cytomegalovirus and herpes simplex virus I seropositivity and this may be associated with schizophrenia risk.

(12) Novoseek inferred disease relationships for MICB Gene

Disease -log(P) Hits PubMed IDs
behcet disease 45.1 1
colitis ulcerative 24.3 5
tumors 20.5 11
celiac disease 19.7 2
autoimmune diseases 19.5 3

Relevant External Links for MICB

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with MICB: view

Publications for MICB Gene

  1. MHC class I chain-related gene B (MICB) is associated with rheumatoid arthritis susceptibility. (PMID: 17003176) Lopez-Arbesu R. … Gonzalez S. (Rheumatology 2007) 3 4 23 48
  2. Release of MICB molecules by tumor cells: mechanism and soluble MICB in sera of cancer patients. (PMID: 16698441) Salih H.R. … Steinle A. (Hum. Immunol. 2006) 3 4 23
  3. MHC class I chain-related gene B promoter polymorphisms and celiac disease. (PMID: 16698444) Rodriguez-Rodero S. … Lopez-Larrea C. (Hum. Immunol. 2006) 3 23 48
  4. AluyMICB dimorphism within the class I region of the major histocompatibility complex is associated with asthma and airflow obstruction in the Busselton population. (PMID: 16776673) Hui J. … Beilby J.P. (Clin. Exp. Allergy 2006) 3 23 48
  5. [The study on the haplotype of MICA and MICB microsatellite locus in Guangzhou Han population]. (PMID: 15640005) Feng M.L. … Ji Y. (Yi Chuan 2004) 3 23 48

Products for MICB Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • T-cell & B-cell Activation in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate MICB
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for MICB
    • Block miRNA regulation of MICB using miScript Target Protectors

    Sources for MICB Gene

    Back to Top