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Aliases for MICB Gene

Aliases for MICB Gene

  • MHC Class I Polypeptide-Related Sequence B 2 3 5
  • PERB11.2 3 4
  • MHC Class I-Like Molecule PERB11.2-IMX 3
  • MHC Class I Chain-Related Protein B 3
  • Stress Inducible Class I Homolog 3
  • MHC Class I Mic-B Antigen 3
  • MIC-B 4

External Ids for MICB Gene

Previous GeneCards Identifiers for MICB Gene

  • GC06P031519
  • GC06P031421
  • GC06P031233
  • GC06P031570
  • GC06P031574
  • GC06P031576
  • GC06P031252

Summaries for MICB Gene

Entrez Gene Summary for MICB Gene

  • This gene encodes a heavily glycosylated protein which is a ligand for the NKG2D type II receptor. Binding of the ligand activates the cytolytic response of natural killer (NK) cells, CD8 alphabeta T cells, and gammadelta T cells which express the receptor. This protein is stress-induced and is similar to MHC class I molecules; however, it does not associate with beta-2-microglobulin or bind peptides. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

GeneCards Summary for MICB Gene

MICB (MHC Class I Polypeptide-Related Sequence B) is a Protein Coding gene. Diseases associated with MICB include Dengue Shock Syndrome and Asymptomatic Dengue. Among its related pathways are Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell and Immune System. GO annotations related to this gene include antigen binding and natural killer cell lectin-like receptor binding. An important paralog of this gene is MICA.

UniProtKB/Swiss-Prot for MICB Gene

  • Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis.

Gene Wiki entry for MICB Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MICB Gene

Genomics for MICB Gene

Regulatory Elements for MICB Gene

Enhancers for MICB Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F031567 1.8 FANTOM5 Ensembl ENCODE 22.2 +84.0 83994 22.5 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF548 DDX39B TNF LY6G5B DHX16 ATF6B LSM2 MICA TCF19 C6orf47 PPT2
GH06F031493 1.1 ENCODE 34.4 +1.7 1674 5.2 PKNOX1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207 DDX39B MICB LY6G5B ATF6B ABCF1 ATP6V1G2 DHX16 LSM2 PPP1R10 C4B
GH06F031596 1.3 Ensembl ENCODE 21.6 +103.4 103432 2.6 PKNOX1 ATF1 ARNT ARID4B FEZF1 ZNF48 ZNF2 YY1 ZNF143 ZNF263 MICB BAG6 C4A GPANK1 DDX39B DHX16 VARS CSNK2B MICA LST1
GH06F031538 1.2 ENCODE 21.7 +46.9 46862 4.9 CREB3L1 MLX ZFP64 FEZF1 DMAP1 YY1 ZNF263 MCM3 SP3 TBX21 DDX39B LY6G5B ATF6B DHX16 PPP1R10 LSM2 SKIV2L RPL3P2 TCF19 ABCF1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MICB on UCSC Golden Path with GeneCards custom track

Promoters for MICB Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000264406 523 2401 PKNOX1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143

Genomic Location for MICB Gene

31,494,277 bp from pter
31,511,124 bp from pter
16,848 bases
Plus strand

Genomic View for MICB Gene

Genes around MICB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MICB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MICB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for MICB Gene

  • Protein details for MICB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    MHC class I polypeptide-related sequence B
    Protein Accession:
    Secondary Accessions:
    • A2AC57
    • A6NP85
    • B0UZ10
    • B2RAK2
    • O14499
    • O14500
    • O19798
    • O19799
    • O19800
    • O19801
    • O19802
    • O19803
    • O78099
    • O78100
    • O78101
    • O78102
    • O78103
    • O78104
    • P79525
    • P79541
    • Q5GR31
    • Q5GR37
    • Q5GR41
    • Q5GR42
    • Q5GR43
    • Q5GR44
    • Q5GR46
    • Q5GR48
    • Q5RIY6
    • Q5SSK1
    • Q5ST25
    • Q7JK51
    • Q7YQ89
    • Q861E6
    • Q9MY18
    • Q9MY19
    • Q9MY20
    • Q9UBH4
    • Q9UBZ8
    • Q9UEJ0

    Protein attributes for MICB Gene

    383 amino acids
    Molecular mass:
    42646 Da
    Quaternary structure:
    • Unlike classical MHC class I molecules, does not form a heterodimer with beta-2-microglobulin. Binds as a monomer to a KLRK1/NKG2D homodimer. KLRK1 forms a complex with HCST/DAP10 in which KLRK1 binds MICB while HCST acts as an adapter molecule which enables signal transduction. Receptor-ligand interaction induces clustering of both proteins in ordered structures called immune synapses and also leads to their intercellular transfer. This is associated with a reduction in the cytotoxicity of KLRK1-expressing cells. Binds to human cytomegalovirus glycoprotein UL16 which causes sequestration of MICB in the endoplasmic reticulum and increases resistance to KLRK1-mediated cytotoxicity.

    Three dimensional structures from OCA and Proteopedia for MICB Gene

    Alternative splice isoforms for MICB Gene


neXtProt entry for MICB Gene

Post-translational modifications for MICB Gene

  • Proteolytically cleaved and released from the cell surface of tumor cells.
  • Ubiquitination at Lys 196
  • Glycosylation at Asn 164, Asn 210, Asn 220, and Asn 261
  • Modification sites at PhosphoSitePlus

Other Protein References for MICB Gene

No data available for DME Specific Peptides for MICB Gene

Domains & Families for MICB Gene

Gene Families for MICB Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 Ig-like C1-type (immunoglobulin-like) domain.
  • Belongs to the MHC class I family. MIC subfamily.
  • Contains 1 Ig-like C1-type (immunoglobulin-like) domain.
  • Belongs to the MHC class I family. MIC subfamily.
genes like me logo Genes that share domains with MICB: view

Function for MICB Gene

Molecular function for MICB Gene

GENATLAS Biochemistry:
MHC class I,chain-related gene B,preferentially expressed in fibroblast and epithelial cell
UniProtKB/Swiss-Prot Function:
Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis.
UniProtKB/Swiss-Prot Induction:
By heat shock, oxidative stress, retinoic acid, IFN-alpha and the DNA methyltransferase inhibitor 5-aza-2-deoxycytidine. Induction by IFN-alpha is impaired in patients with chronic hepatitis C virus infection. Down-regulated by human cytomegalovirus UL112 microRNA during viral infection which leads to decreased binding of KLRK1/NKG2D and reduced killing by natural killer cells.

Gene Ontology (GO) - Molecular Function for MICB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding IBA --
GO:0046703 natural killer cell lectin-like receptor binding IDA 11491531
genes like me logo Genes that share ontologies with MICB: view
genes like me logo Genes that share phenotypes with MICB: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MICB Gene

Localization for MICB Gene

Subcellular locations from UniProtKB/Swiss-Prot for MICB Gene

Cell membrane; Single-pass type I membrane protein. Note=Binding to human cytomegalovirus glycoprotein UL16 causes sequestration in the endoplasmic reticulum. {ECO:0000250 UniProtKB:Q29983, ECO:0000269 PubMed:12782710}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MICB gene
Compartment Confidence
plasma membrane 4
extracellular 2

Gene Ontology (GO) - Cellular Components for MICB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0009986 cell surface ISS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MICB: view

Pathways & Interactions for MICB Gene

genes like me logo Genes that share pathways with MICB: view

Interacting Proteins for MICB Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000252229 Q29980-MICB_HUMAN for MICB Gene via STRING IID

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for MICB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001913 T cell mediated cytotoxicity IBA --
GO:0002250 adaptive immune response IEA --
GO:0002376 immune system process IEA --
GO:0002429 immune response-activating cell surface receptor signaling pathway IDA 11491531
GO:0006979 response to oxidative stress IDA 11287116
genes like me logo Genes that share ontologies with MICB: view

No data available for SIGNOR curated interactions for MICB Gene

Drugs & Compounds for MICB Gene

(3) Drugs for MICB Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Peginterferon alfa-2a Approved, Investigational Pharma 563
Peginterferon alfa-2b Approved Pharma 308
Ribavirin Approved Pharma 984
genes like me logo Genes that share compounds with MICB: view

Transcripts for MICB Gene

Unigene Clusters for MICB Gene

MHC class I polypeptide-related sequence B:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MICB Gene

No ASD Table

Relevant External Links for MICB Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MICB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MICB Gene

mRNA differential expression in normal tissues according to GTEx for MICB Gene

This gene is overexpressed in Whole Blood (x8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MICB Gene

NURSA nuclear receptor signaling pathways regulating expression of MICB Gene:


SOURCE GeneReport for Unigene cluster for MICB Gene:


mRNA Expression by UniProt/SwissProt for MICB Gene:

Tissue specificity: Widely expressed with the exception of the central nervous system where it is absent. Expressed in many, but not all, epithelial tumors of lung, breast, kidney, ovary, prostate and colon. In hepatocellular carcinomas, expressed in tumor cells but not in surrounding non-cancerous tissue.
genes like me logo Genes that share expression patterns with MICB: view

Primer Products

No data available for Protein differential expression in normal tissues and Protein tissue co-expression partners for MICB Gene

Orthologs for MICB Gene

This gene was present in the common ancestor of chordates.

Orthologs for MICB Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MICB 34 35
  • 93.98 (n)
(Bos Taurus)
Mammalia MIC1 34
  • 70.74 (n)
-- 35
  • 46 (a)
(Mus musculus)
Mammalia Mill2 34 16 35
  • 56.11 (n)
(Rattus norvegicus)
Mammalia Micb 34
  • 53.24 (n)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 26 (a)
-- 35
  • 22 (a)
-- 35
  • 22 (a)
-- 35
  • 20 (a)
-- 35
  • 20 (a)
-- 35
  • 19 (a)
-- 35
  • 17 (a)
-- 35
  • 17 (a)
-- 35
  • 17 (a)
(Monodelphis domestica)
Mammalia MILL-LIKE 35
  • 25 (a)
(Gallus gallus)
Aves -- 35
  • 25 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 21 (a)
(Danio rerio)
Actinopterygii si:ch211-147g22.4 35
  • 23 (a)
mhc1uba 35
  • 20 (a)
mhc1uca 35
  • 20 (a)
mhc1zca 35
  • 20 (a)
si:dkey-52p2.7 35
  • 20 (a)
BX572619.1 35
  • 19 (a)
BX572619.2 35
  • 19 (a)
BX572619.3 35
  • 19 (a)
BX682558.1 35
  • 19 (a)
CR339041.1 35
  • 19 (a)
mhc1zea 35
  • 19 (a)
mhc1zfa 35
  • 19 (a)
si:ch211-147g22.1 35
  • 19 (a)
si:ch211-147g22.3 35
  • 19 (a)
arpc1a 35
  • 18 (a)
DARE-ZE*0601 35
  • 18 (a)
si:ch211-147g22.2 35
  • 18 (a)
si:dkey-52p2.6 35
  • 18 (a)
CABZ01031753.1 35
  • 17 (a)
CABZ01031754.1 35
  • 17 (a)
CR339041.2 35
  • 17 (a)
CU571323.1 35
  • 17 (a)
mhc1zaa 35 35
  • 17 (a)
mhc1zba 35
  • 17 (a)
si:dkey-52p2.4 35
  • 16 (a)
zgc:113060 35
  • 14 (a)
Species where no ortholog for MICB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MICB Gene

Gene Tree for MICB (if available)
Gene Tree for MICB (if available)

Paralogs for MICB Gene

Paralogs for MICB Gene

genes like me logo Genes that share paralogs with MICB: view

Variants for MICB Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for MICB Gene

The following alleles of MICB are known: MICB*001, MICB*002, MICB*003, MICB*004, MICB*005, MICB*006, MICB*007, MICB*008, MICB*009N, MICB*010, MICB*011, MICB*012, MICB*013, MICB*014, MICB*015, MICB*016, MICB*018, MICB*019, MICB*020, MICB*021N and MICB*022. MICB*009N and MICB*021N are null alleles which are not expressed. The sequence shown is that of MICB*001.

Sequence variations from dbSNP and Humsavar for MICB Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1051788 -- 31,506,223(+) ACTAC(A/G)ATGGG intron-variant, reference, missense
rs1065075 -- 31,505,784(+) GAGCT(A/G)AGACC reference, missense
rs1065076 -- 31,509,904(+) AGGGC(A/G)CCTAG reference, missense
rs10661543 -- 31,494,828(+) GTTTC(-/AAAA/AAAAA)AAAAA upstream-variant-2KB
rs10688829 -- 31,496,205(+) TTAGT(-/AGAA)AGAGG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MICB Gene

Variant ID Type Subtype PubMed ID
nsv601940 CNV loss 21841781
nsv517441 CNV gain+loss 19592680
nsv462869 CNV loss 19166990
nsv1126749 CNV deletion 24896259
nsv1112900 CNV deletion 24896259
nsv10821 CNV loss 18304495
nsv1073969 CNV deletion 25765185
nsv1025961 CNV loss 25217958
nsv1022499 CNV gain 25217958
nsv1021578 CNV gain 25217958
nsv1018960 CNV gain 25217958
nsv1015886 CNV loss 25217958
esv3890821 CNV gain 25118596
esv2759414 CNV gain+loss 17122850
esv2731822 CNV deletion 23290073
dgv995e201 CNV deletion 23290073
dgv5944n100 CNV loss 25217958
dgv5943n100 CNV gain+loss 25217958
dgv5942n100 CNV loss 25217958
dgv215e55 CNV loss 17911159
dgv213e55 CNV gain 17911159
dgv10460n54 CNV gain 21841781
dgv10404n54 CNV loss 21841781
dgv10403n54 CNV loss 21841781

Variation tolerance for MICB Gene

Residual Variation Intolerance Score: 71.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.90; 74.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MICB Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

Disorders for MICB Gene

MalaCards: The human disease database

(6) MalaCards diseases for MICB Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
dengue shock syndrome
  • dss
asymptomatic dengue
behcet syndrome
  • behcet's disease
celiac disease
  • celiac sprue
rheumatoid arthritis
  • rheumatoid arthritis, progression of
- elite association - COSMIC cancer census association via MalaCards
Search MICB in MalaCards View complete list of genes associated with diseases


  • Note=Genetic variation in MICB is associated with cytomegalovirus and herpes simplex virus I seropositivity and this may be associated with schizophrenia risk.
  • Rheumatoid arthritis (RA) [MIM:180300]: An inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. {ECO:0000269 PubMed:17003176}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. The MICB*004 allele is associated with rheumatoid arthritis.

Relevant External Links for MICB

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with MICB: view

No data available for Genatlas for MICB Gene

Publications for MICB Gene

  1. MHC class I chain-related gene B (MICB) is associated with rheumatoid arthritis susceptibility. (PMID: 17003176) Lopez-Arbesu R. … Gonzalez S. (Rheumatology 2007) 3 4 22 46 64
  2. MICB0106 gene polymorphism is associated with ulcerative colitis in central China. (PMID: 19662431) Li Y. … Zhang X. (Int J Colorectal Dis 2010) 3 22 46 64
  3. Genomewide association study of an AIDS-nonprogression cohort emphasizes the role played by HLA genes (ANRS Genomewide Association Study 02). (PMID: 19115949) Limou S. … Zagury J.F. (J. Infect. Dis. 2009) 3 22 46 64
  4. Sequencing-based genotyping and association analysis of the MICA and MICB genes in type 1 diabetes. (PMID: 18332098) Field S.F. … Todd J.A. (Diabetes 2008) 3 22 46 64
  5. Genetic influence of the nonclassical major histocompatibility complex class I molecule MICB in multiple sclerosis susceptibility. (PMID: 18588574) Fernandez-Morera J.L. … Lopez-Larrea C. (Tissue Antigens 2008) 3 22 46 64

Products for MICB Gene

Sources for MICB Gene

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