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MICB Gene

protein-coding   GIFtS: 61
GCID: GC06P031465

MHC Class I Polypeptide-Related Sequence B

  See MICB-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
MHC Class I Polypeptide-Related Sequence B1 2     MHC Class I-Like Molecule PERB11.2-IMX2
PERB11.22 3     Stress Inducible Class I Homolog2
MHC Class I Chain-Related Protein B2     MIC-B3
MHC Class I Mic-B Antigen2     

External Ids:    HGNC: 70911   Entrez Gene: 42772   Ensembl: ENSG000002045167   OMIM: 6024365   UniProtKB: Q299803   

Export aliases for MICB gene to outside databases

Previous GC identifers: GC06P031519 GC06P031421 GC06P031233 GC06P031570 GC06P031574 GC06P031576 GC06P031252


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MICB Gene:
This gene encodes a heavily glycosylated protein which is a ligand for the NKG2D type II receptor. Binding of the
ligand activates the cytolytic response of natural killer (NK) cells, CD8 alphabeta T cells, and gammadelta T
cells which express the receptor. This protein is stress-induced and is similar to MHC class I molecules;
however, it does not associate with beta-2-microglobulin or bind peptides. Alternative splicing results in
multiple transcript variants. (provided by RefSeq, Jan 2014)

GeneCards Summary for MICB Gene:
MICB (MHC class I polypeptide-related sequence B) is a protein-coding gene. Diseases associated with MICB include dengue shock syndrome, and behcet's disease. GO annotations related to this gene include antigen binding and natural killer cell lectin-like receptor binding. An important paralog of this gene is MICA.

UniProtKB/Swiss-Prot: MICB_HUMAN, Q29980
Function: Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized
by gamma delta T cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis

Gene Wiki entry for MICB Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the MICB gene promoter:
         POU2F1   Sp1   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMICB promoter sequence
   Search Chromatin IP Primers for MICB

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MICB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p21.33   HGNC cytogenetic band: 6p21.3

MICB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MICB gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P031465:  view genomic region     (about GC identifiers)

Start:
31,462,658 bp from pter      End:
31,478,901 bp from pter
Size:
16,244 bases      Orientation:
plus strand

Selected alternative locations (see all 7):
Chr6+,NT_167248 2,759,574-2,772,598      Chr6+,NT_167245 2,751,271-2,764,495      Chr6+,NT_113891.2 2,975,524-2,988,570     
Chr6+,NT_167244 2,780,562-2,793,590      Chr6+,NT_167246 2,816,315-2,821,820      Chr6+,NT_167249 2,796,671-2,809,708     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MICB_HUMAN, Q29980 (See protein sequence)
Recommended Name: MHC class I polypeptide-related sequence B precursor  
Size: 383 amino acids; 42646 Da
Subunit: Unlike classical MHC class I molecules, does not form a heterodimer with beta-2-microglobulin. Binds as a
monomer to a KLRK1/NKG2D homodimer. KLRK1 forms a complex with HCST/DAP10 in which KLRK1 binds MICB while HCST
acts as an adapter molecule which enables signal transduction. Receptor-ligand interaction induces clustering of
both proteins in ordered structures called immune synapses and also leads to their intercellular transfer. This
is associated with a reduction in the cytotoxicity of KLRK1-expressing cells. Binds to human cytomegalovirus
glycoprotein UL16 which causes sequestration of MICB in the endoplasmic reticulum and increases resistance to
KLRK1-mediated cytotoxicity
2 PDB 3D structures from and Proteopedia for MICB:
1JE6 (3D)        2WY3 (3D)    
Secondary accessions: A6NP85 B0UZ10 O14499 O14500 O19798 O19799 O19800 O19801 O19802 O19803
O78099 O78100 O78101 O78102 O78103 O78104 P79525 P79541 Q5GR31 Q5GR37 Q5GR41 Q5GR42 Q5GR43
Q5GR44 Q5GR46 Q5GR48 Q5RIY6 Q5SSK1 Q5ST25 Q7JK51 Q7YQ89 Q9MY18 Q9MY19 Q9MY20 Q9UBH4 Q9UBZ8
Q9UEJ0
Alternative splicing: 3 isoforms:  Q29980-1   Q29980-2   Q29980-3   (A GC to AG nucleotide substitution in intron 1 generates a splice junction which gives rise to an additional exon between exons 1 and 2. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for MICB: NX_Q29980

Explore proteomics data for MICB at MOPED

Post-translational modifications: 

  • Proteolytically cleaved and released from the cell surface of tumor cells1
  • Ubiquitination2 at Lys196
  • Glycosylation2 at Asn164, Asn210, Asn220, Asn261
  • Modification sites at PhosphoSitePlus

  • See MICB Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001276089.1  NP_001276090.1  NP_005922.2  

    ENSEMBL proteins: 
     ENSP00000382103   ENSP00000252229   ENSP00000395391   ENSP00000442345  
    Reactome Protein details: Q29980

    MICB Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Protein Over-expression Lysate for MICB
    OriGene MassSpec for MICB
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    GenScript Purified and Recombinant Proteins for MICB
    Novus Biologicals MICB Proteins
    Novus Biologicals MICB Lysates
    Sino Biological Recombinant Protein for MICB
    Sino Biological Cell Lysate for MICB
    ProSpec Recombinant Protein for MICB
    Cloud-Clone Corp. Proteins for MICB

     
    Search eBioscience for Proteins for MICB 

    MICB Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Novus Biologicals MICB Antibodies
    Abcam antibodies for MICB
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    MICB Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    R&D Systems ELISAs for MICB         (see all)
    GenScript Custom Assay Services for MICB
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MICB
    Cloud-Clone Corp. CLIAs for MICB
    Search eBioscience for ELISAs for MICB 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    C1SET: Immunoglobulin superfamily / C1-set domain containing

    Selected InterPro protein domains (see all 6):
     IPR011162 MHC_I/II-like_Ag-recog
     IPR013783 Ig-like_fold
     IPR003597 Ig_C1-set
     IPR007110 Ig-like_dom
     IPR011161 MHC_I-like_Ag-recog

    Graphical View of Domain Structure for InterPro Entry Q29980

    ProtoNet protein and cluster: Q29980

    1 Blocks protein domain: IPB003597 Immunoglobulin C-type

    UniProtKB/Swiss-Prot: MICB_HUMAN, Q29980
    Similarity: Belongs to the MHC class I family. MIC subfamily
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain


    Find genes that share domains with MICB           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MICB_HUMAN, Q29980
    Function: Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized
    by gamma delta T cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis
    Induction: By heat shock, oxidative stress, retinoic acid, IFN-alpha and the DNA methyltransferase inhibitor
    5-aza-2'-deoxycytidine. Induction by IFN-alpha is impaired in patients with chronic hepatitis C virus infection.
    Down-regulated by human cytomegalovirus UL112 microRNA during viral infection which leads to decreased binding of
    KLRK1/NKG2D and reduced killing by natural killer cells

         Genatlas biochemistry entry for MICB:
    MHC class I,chain-related gene B,preferentially expressed in fibroblast and epithelial cell

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003823antigen binding IBA--
    GO:0005515protein binding ----
    GO:0030881NOT beta-2-microglobulin binding IBA--
    GO:0046703natural killer cell lectin-like receptor binding IDA11491531
         
    Find genes that share ontologies with MICB           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for MICB:
     Decreased viability with pacli  Increased G2M DNA content  Increased number of mitotic ce 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MICB
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MICB

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MICB
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MICB

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidMICB 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MICB
    Predesigned siRNA for gene silencing in human, mouse, rat MICB

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MICB

    Clone
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    OriGene clones in human, mouse for MICB (see all 8)
    OriGene ORF clones in mouse, rat for MICB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MICB (NM_005931)
    Sino Biological Human cDNA Clone for MICB
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MICB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MICB

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for MICB 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MICB


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MICB_HUMAN, Q29980: Cell membrane; Single-pass type I membrane protein (By similarity). Note=Binding to human
    cytomegalovirus glycoprotein UL16 causes sequestration in the endoplasmic reticulum
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular2

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0009986cell surface ISS--
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with MICB           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MICB About    
    See pathways by source

    SuperPathContained pathways About
    1Class I MHC mediated antigen processing and presentation
    Adaptive Immune System0.41
    2Immune response Role of DAP12 receptors in NK cells
    Natural killer cell mediated cytotoxicity0.31
    3Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
    Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell


    Find genes that share SuperPaths with MICB           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for MICB
        Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell


    1 Kegg Pathway  (Kegg details for MICB):
        Natural killer cell mediated cytotoxicity

        Pathway & Disease-focused RT2 Profiler PCR Array including MICB: 
              T-cell & B-cell Activation in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for MICB

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for MICB (Q299803 ENSP000002522294) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KLRK1P267183, ENSP000002406184I2D: score=2 STRING: ENSP00000240618
    KLRC4O439083, ENSP000003102164I2D: score=1 STRING: ENSP00000310216
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001913T cell mediated cytotoxicity IBA--
    GO:0002429immune response-activating cell surface receptor signaling pathway IDA11491531
    GO:0006955immune response ----
    GO:0006979response to oxidative stress IDA11287116
    GO:0009408response to heat IDA9497295

    Find genes that share ontologies with MICB           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MICB



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MICB gene (3 alternative transcripts): 
    NM_001289160.1  NM_001289161.1  NM_005931.4  

    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000399150(uc003nto.4) ENST00000252229(uc011dnm.2 uc003ntn.4)
    ENST00000494577 ENST00000427115 ENST00000538442(uc021yuq.1)
    miRNA
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    Search for qRT-PCR Assays for microRNAs that regulate MICB
    SwitchGear 3'UTR luciferase reporter plasmidMICB 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for MICB
    Predesigned siRNA for gene silencing in human, mouse, rat MICB
    Clone
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    OriGene ORF clones in mouse, rat for MICB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MICB (NM_005931)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MICB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MICB
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MICB
      QuantiTect SYBR Green Assays in human, mouse, rat MICB
      QuantiFast Probe-based Assays in human, mouse, rat MICB

    Selected AceView cDNA sequences (see all 43):

    BX462489 U95734 BQ056005 AF021224 AF021222 BQ928510 AF021221 U95730 
    BV200700 BI868468 BU958824 BG118546 BP340573 AF021226 U95729 AF021223 
    BQ430350 BP358327 U95733 BU182708 U95732 BV204449 X91625 U95731 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MICB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGTGAACTTT
    MICB Expression
    About this image


    MICB expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Human embryonic stem cells (family)
     
     Neural Tube (Nervous System)
             Floor plate-like cells
    MICB Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MICB Protein Expression

    UniProtKB/Swiss-Prot: MICB_HUMAN, Q29980
    Tissue specificity: Widely expressed with the exception of the central nervous system where it is absent.
    Expressed in many, but not all, epithelial tumors of lung, breast, kidney, ovary, prostate and colon. In
    hepatocellular carcinomas, expressed in tumor cells but not in surrounding non-cancerous tissue

        Pathway & Disease-focused RT2 Profiler PCR Array including MICB: 
              T-cell & B-cell Activation in human mouse rat

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    QuantiFast Probe-based Assays in human, mouse, rat MICB
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MICB

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for MICB gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mill21 , 5 MHC I like leukocyte 21, 5 56.11(n)1
    38.22(a)1
      7 (9.35 cM)5
    2438641  NM_153760.21  NP_715641.11 
     188399665 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    25(a)
    1 → many
    AADN03014659.1(517-1002)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    21(a)
    1 → many
    GL343777.1(59223-67524)
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch211-147g22.46
    mhc1uca6
    (see all 27)
    major histocompatibility complex class I UCA
    (see all 27)
    23(a)
    20(a)
    (see all 27)
    many ↔ many
    many ↔ many
    (see all 27)
    25(11210638-11221812) ENSDARG00000097275
    19(7666170-7674017) ENSDARG00000092731


    ENSEMBL Gene Tree for MICB (if available)
    TreeFam Gene Tree for MICB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MICB gene
    MICA2  
    Selected SIMAP similar genes for MICB using alignment to 8 protein entries:     MICB_HUMAN (see all proteins) (see all similar genes):
    MICA    HLA-MICA    DKFZp762B162    PERB11.1    HLA-A*0201V3    HFE
    Cw    HLA-A*33    HLA-DQB1    B*56    HLA-A*02    HLA-A*0226
    HLA-A*31    HLA-A24AK    HLA-Cw*    HLA-Cw*15P    HLA-H    MHC class I HLA-A

    Find genes that share paralogs with MICB           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for MICB
    PGOHUM00000243132 PGOHUM00000243573


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    MICB_HUMAN, Q29980: The following alleles of MICB are known: MICB*001, MICB*002, MICB*003, MICB*004, MICB*005, MICB*006,
    MICB*007, MICB*008, MICB*009N, MICB*010, MICB*011, MICB*012, MICB*013, MICB*014, MICB*015, MICB*016, MICB*018,
    MICB*019, MICB*020, MICB*021N and MICB*022. MICB*009N and MICB*021N are null alleles which are not expressed. The
    sequence shown is that of MICB*001


    Selected SNPs for MICB (see all 490)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs69161871,2
    C,F,A,H--31463926(+) accacT/CgCCTA 2 -- us2k19Minor allele frequency- C:0.36NS EA NA WA 780
    rs1403050031,2
    C--31463956(+) ATGTGC/TGCTGG 2 -- us2k10--------
    rs25346781,2
    C,F,A,H--31463963(-) CTTGTC/ACCCAG 2 -- us2k16Minor allele frequency- A:0.17NA WA EA 364
    rs92815081,2
    C--31463985(+) GTAGA-/AAGA  
            
    GGCTT
    2 -- us2k10--------
    rs25346771,2
    C,F--31464026(-) ATGTGA/GATTCT 2 -- us2k17Minor allele frequency- G:0.17NA WA EA 366
    rs25346761,2
    C,F,A,H--31464029(-) ggcatA/Gtgaat 2 -- us2k18Minor allele frequency- G:0.35WA NA CSA EA 367
    rs69163941,2
    C,F,A,H--31464050(+) tatcgT/Ctttaa 2 -- us2k125Minor allele frequency- C:0.38NS EA NA WA 3350
    rs412938601,2
    C,F--31464091(+) CACAAG/AGTTGT 2 -- us2k11Minor allele frequency- A:0.04NA 120
    rs1130136841,2
    C--31464188(+) GCCCAG/AGCTGG 2 -- us2k11Minor allele frequency- A:0.50NA 2
    rs92673661,2
    C--31464229(+) AGCTCC/TGCCTC 2 -- us2k11Minor allele frequency- T:0.50NA 2

    HapMap Linkage Disequilibrium report for MICB (31462658 - 31478901 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for MICB (see all 13):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv1042e201CNV Deletion23290073
    esv2731822CNV Deletion23290073
    nsv462869CNV Loss19166990
    dgv215e55CNV Loss17911159
    nsv10821CNV Loss18304495
    nsv884412CNV Gain21882294
    dgv213e55CNV Gain17911159
    dgv6580n71CNV Gain21882294
    nsv884413CNV Gain21882294
    essv13266CNV CNV17122850

    Human Gene Mutation Database (HGMD): MICB
    Locus Specific Mutation Databases (LSDB): MICB

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MICB
    DNA2.0 Custom Variant and Variant Library Synthesis for MICB

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 602436    OMIM disorders: --

    UniProtKB/Swiss-Prot: MICB_HUMAN, Q29980
  • Rheumatoid arthritis (RA) [MIM:180300]: An inflammatory disease with autoimmune features and a complex
    genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial
    membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal
    tissues, and by atrophy and rarefaction of bony structures. Note=Disease susceptibility is associated with
    variations affecting the gene represented in this entry. The MICB*004 allele is associated with rheumatoid
    arthritis
  • Note=Genetic variation in MICB is associated with cytomegalovirus and herpes simplex virus I
    seropositivity and this may be associated with schizophrenia risk

  • 2 diseases for MICB:    
    About MalaCards
    dengue shock syndrome    behcet's disease


    Find genes that share disorders with MICB           About GenesLikeMe

    Selected Novoseek inferred disease relationships for MICB gene (see all 12)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    behcet disease 45.1 1 9712354 (1)
    colitis ulcerative 24.3 5 11782275 (3), 19662431 (1), 18785505 (1)
    tumors 20.5 17 16698441 (3), 12714493 (1), 17510432 (1), 17557375 (1) (see all 9)
    celiac disease 19.7 3 16698444 (1), 15089901 (1)
    autoimmune diseases 19.5 5 19662431 (1), 12799463 (1), 17557375 (1)
    genetic susceptibility 18.9 2 11584356 (1), 16923796 (1)
    cancer 16 6 16698441 (1), 18505429 (1), 16866882 (1), 17181741 (1)
    colon carcinoma 14.5 4 11287116 (2), 12466900 (1)
    inflammatory bowel diseases 12.9 3 11782275 (2), 11584356 (1)
    virus infection 0 2 12799463 (1), 17641203 (1)

    Genetic Association Database (GAD): MICB
    Human Genome Epidemiology (HuGE) Navigator: MICB (31 documents)

    Export disorders for MICB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for MICB gene, integrated from 10 sources (see all 197):
    (articles sorted by number of sources associating them with MICB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. MHC class I chain-related gene B (MICB) is associated with rheumatoid arthritis susceptibility. (PubMed id 17003176)1, 2, 4, 9 Lopez-Arbesu R.... Gonzalez S. (Rheumatology 2007)
    2. Polymorphisms in MICB are associated with human herpes virus seropositivity and schizophrenia risk. (PubMed id 17561376)1, 2, 4 Shirts B.H.... Nimgaonkar V.L. (Schizophr. Res. 2007)
    3. Sequencing-based genotyping and association analysis of the MICA and MICB genes in type 1 diabetes. (PubMed id 18332098)1, 4, 9 Field S.F....Todd J.A. (Diabetes 2008)
    4. MHC class I chain-related gene B promoter polymorphisms and celiac disease. (PubMed id 16698444)1, 4, 9 Rodriguez-Rodero S....Lopez-Larrea C. (Hum. Immunol. 2006)
    5. Associations of MICB with cervical cancer in north-eastern Thais: identification of major histocompatibility complex class I chain-related gene B motifs influencing natural killer cell activation. (PubMed id 18505429)1, 4, 9 Jumnainsong A....Leelayuwat C. (Clin. Exp. Immunol. 2008)
    6. Release of MICB molecules by tumor cells: mechanism and soluble MICB in sera of cancer patients. (PubMed id 16698441)1, 2, 9 Salih H.R.... Steinle A. (Hum. Immunol. 2006)
    7. Study on the haplotypes of MICA and MICB microsatellite and HLA-B locus in the Guangzhou Han population. (PubMed id 15304009)1, 4, 9 Feng M.L....Qian K.C. (Tissue Antigens 2004)
    8. [The study on the haplotype of MICA and MICB microsatellite locus in Guangzhou Han population]. (PubMed id 15640005)1, 4, 9 Feng M.L....Ji Y. (Yi Chuan 2004)
    9. Allelic variants of the human MHC class I chain-related B gene (MICB). (PubMed id 9321430)1, 2, 9 Ando H.... Inoko H. (Immunogenetics 1997)
    10. Alternatively spliced forms of MICA and MICB lacking exon 3 in a human cell line and evidence of presence of similar RNA in human peripheral blood mononuclear cells. (PubMed id 12466900)1, 2, 9 Zou Y. and Stastny P. (Immunogenetics 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 4277 HGNC: 7091 AceView: MICB Ensembl:ENSG00000204516 euGenes: HUgn4277
    ECgene: MICB Kegg: 4277 H-InvDB: MICB

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for MICB Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for MICB gene:
    Search GeneIP for patents involving MICB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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