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Aliases for MICB Gene

Aliases for MICB Gene

  • MHC Class I Polypeptide-Related Sequence B 2 3 5
  • PERB11.2 3 4
  • MHC Class I-Like Molecule PERB11.2-IMX 3
  • MHC Class I Chain-Related Protein B 3
  • Stress Inducible Class I Homolog 3
  • MHC Class I Mic-B Antigen 3
  • MIC-B 4

External Ids for MICB Gene

Previous GeneCards Identifiers for MICB Gene

  • GC06P031519
  • GC06P031421
  • GC06P031233
  • GC06P031570
  • GC06P031574
  • GC06P031576
  • GC06P031252

Summaries for MICB Gene

Entrez Gene Summary for MICB Gene

  • This gene encodes a heavily glycosylated protein which is a ligand for the NKG2D type II receptor. Binding of the ligand activates the cytolytic response of natural killer (NK) cells, CD8 alphabeta T cells, and gammadelta T cells which express the receptor. This protein is stress-induced and is similar to MHC class I molecules; however, it does not associate with beta-2-microglobulin or bind peptides. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

GeneCards Summary for MICB Gene

MICB (MHC Class I Polypeptide-Related Sequence B) is a Protein Coding gene. Diseases associated with MICB include Dengue Shock Syndrome and Asymptomatic Dengue. Among its related pathways are Natural Killer Cell Receptors: Human Target Cell ?�� NK Cell Ligand-Receptor Interactions and Immune System. GO annotations related to this gene include antigen binding and natural killer cell lectin-like receptor binding. An important paralog of this gene is MICA.

UniProtKB/Swiss-Prot for MICB Gene

  • Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis.

Gene Wiki entry for MICB Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MICB Gene

Genomics for MICB Gene

Regulatory Elements for MICB Gene

Enhancers for MICB Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MICB on UCSC Golden Path with GeneCards custom track

Promoters for MICB Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MICB on UCSC Golden Path with GeneCards custom track

Genomic Location for MICB Gene

31,494,277 bp from pter
31,511,124 bp from pter
16,848 bases
Plus strand

Genomic View for MICB Gene

Genes around MICB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MICB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MICB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for MICB Gene

  • Protein details for MICB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    MHC class I polypeptide-related sequence B
    Protein Accession:
    Secondary Accessions:
    • A2AC57
    • A6NP85
    • B0UZ10
    • B2RAK2
    • O14499
    • O14500
    • O19798
    • O19799
    • O19800
    • O19801
    • O19802
    • O19803
    • O78099
    • O78100
    • O78101
    • O78102
    • O78103
    • O78104
    • P79525
    • P79541
    • Q5GR31
    • Q5GR37
    • Q5GR41
    • Q5GR42
    • Q5GR43
    • Q5GR44
    • Q5GR46
    • Q5GR48
    • Q5RIY6
    • Q5SSK1
    • Q5ST25
    • Q7JK51
    • Q7YQ89
    • Q861E6
    • Q9MY18
    • Q9MY19
    • Q9MY20
    • Q9UBH4
    • Q9UBZ8
    • Q9UEJ0

    Protein attributes for MICB Gene

    383 amino acids
    Molecular mass:
    42646 Da
    Quaternary structure:
    • Unlike classical MHC class I molecules, does not form a heterodimer with beta-2-microglobulin. Binds as a monomer to a KLRK1/NKG2D homodimer. KLRK1 forms a complex with HCST/DAP10 in which KLRK1 binds MICB while HCST acts as an adapter molecule which enables signal transduction. Receptor-ligand interaction induces clustering of both proteins in ordered structures called immune synapses and also leads to their intercellular transfer. This is associated with a reduction in the cytotoxicity of KLRK1-expressing cells. Binds to human cytomegalovirus glycoprotein UL16 which causes sequestration of MICB in the endoplasmic reticulum and increases resistance to KLRK1-mediated cytotoxicity.

    Three dimensional structures from OCA and Proteopedia for MICB Gene

    Alternative splice isoforms for MICB Gene


neXtProt entry for MICB Gene

Proteomics data for MICB Gene at MOPED

Post-translational modifications for MICB Gene

  • Proteolytically cleaved and released from the cell surface of tumor cells.
  • Ubiquitination at Lys 196
  • Glycosylation at Asn 164, Asn 210, Asn 220, and Asn 261
  • Modification sites at PhosphoSitePlus

Other Protein References for MICB Gene

No data available for DME Specific Peptides for MICB Gene

Domains & Families for MICB Gene

Gene Families for MICB Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 Ig-like C1-type (immunoglobulin-like) domain.
  • Belongs to the MHC class I family. MIC subfamily.
  • Contains 1 Ig-like C1-type (immunoglobulin-like) domain.
  • Belongs to the MHC class I family. MIC subfamily.
genes like me logo Genes that share domains with MICB: view

Function for MICB Gene

Molecular function for MICB Gene

GENATLAS Biochemistry:
MHC class I,chain-related gene B,preferentially expressed in fibroblast and epithelial cell
UniProtKB/Swiss-Prot Function:
Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis.
UniProtKB/Swiss-Prot Induction:
By heat shock, oxidative stress, retinoic acid, IFN-alpha and the DNA methyltransferase inhibitor 5-aza-2-deoxycytidine. Induction by IFN-alpha is impaired in patients with chronic hepatitis C virus infection. Down-regulated by human cytomegalovirus UL112 microRNA during viral infection which leads to decreased binding of KLRK1/NKG2D and reduced killing by natural killer cells.
genes like me logo Genes that share phenotypes with MICB: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MICB Gene

Localization for MICB Gene

Subcellular locations from UniProtKB/Swiss-Prot for MICB Gene

Cell membrane; Single-pass type I membrane protein. Note=Binding to human cytomegalovirus glycoprotein UL16 causes sequestration in the endoplasmic reticulum. {ECO:0000250 UniProtKB:Q29983, ECO:0000269 PubMed:12782710}.

Subcellular locations from

Jensen Localization Image for MICB Gene COMPARTMENTS Subcellular localization image for MICB gene
Compartment Confidence
plasma membrane 4
extracellular 2

No data available for Gene Ontology (GO) - Cellular Components for MICB Gene

Pathways & Interactions for MICB Gene

genes like me logo Genes that share pathways with MICB: view

Interacting Proteins for MICB Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000252229 Q29980-MICB_HUMAN for MICB Gene via STRING I2D

Gene Ontology (GO) - Biological Process for MICB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006979 response to oxidative stress IDA 11287116
GO:0016032 viral process IEA --
GO:0019835 cytolysis IEA --
GO:0032526 response to retinoic acid IDA 12569559
GO:0042267 natural killer cell mediated cytotoxicity IBA --
genes like me logo Genes that share ontologies with MICB: view

No data available for SIGNOR curated interactions for MICB Gene

Drugs & Compounds for MICB Gene

(3) Drugs for MICB Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Peginterferon alfa-2a Approved, Investigational Pharma 545
Peginterferon alfa-2b Approved Pharma 300
Ribavirin Approved Pharma 962
genes like me logo Genes that share compounds with MICB: view

Transcripts for MICB Gene

Unigene Clusters for MICB Gene

MHC class I polypeptide-related sequence B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MICB Gene

No ASD Table

Relevant External Links for MICB Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MICB Gene

mRNA expression in normal human tissues for MICB Gene

mRNA differential expression in normal tissues according to GTEx for MICB Gene

This gene is overexpressed in Whole Blood (x8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MICB Gene

SOURCE GeneReport for Unigene cluster for MICB Gene Hs.731446

mRNA Expression by UniProt/SwissProt for MICB Gene

Tissue specificity: Widely expressed with the exception of the central nervous system where it is absent. Expressed in many, but not all, epithelial tumors of lung, breast, kidney, ovary, prostate and colon. In hepatocellular carcinomas, expressed in tumor cells but not in surrounding non-cancerous tissue.
genes like me logo Genes that share expression patterns with MICB: view

Primer Products

No data available for Protein differential expression in normal tissues and Protein tissue co-expression partners for MICB Gene

Orthologs for MICB Gene

This gene was present in the common ancestor of chordates.

Orthologs for MICB Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MIC1 35
  • 70.74 (n)
  • 53.05 (a)
-- 36
  • 46 (a)
(Mus musculus)
Mammalia Mill2 35
  • 56.11 (n)
  • 38.22 (a)
Mill2 16
Mill2 36
  • 28 (a)
(Pan troglodytes)
Mammalia MICB 35
  • 93.98 (n)
  • 88.48 (a)
  • 89 (a)
(Rattus norvegicus)
Mammalia Micb 35
  • 53.24 (n)
  • 33.79 (a)
(Monodelphis domestica)
Mammalia MILL-LIKE 36
  • 25 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 22 (a)
-- 36
  • 26 (a)
-- 36
  • 17 (a)
-- 36
  • 20 (a)
-- 36
  • 19 (a)
-- 36
  • 17 (a)
-- 36
  • 17 (a)
-- 36
  • 20 (a)
-- 36
  • 22 (a)
(Gallus gallus)
Aves -- 36
  • 25 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 21 (a)
(Danio rerio)
Actinopterygii arpc1a 36
  • 18 (a)
BX572619.1 36
  • 19 (a)
BX572619.2 36
  • 19 (a)
BX572619.3 36
  • 19 (a)
BX682558.1 36
  • 19 (a)
CABZ01031753.1 36
  • 17 (a)
CABZ01031754.1 36
  • 17 (a)
CR339041.1 36
  • 19 (a)
CR339041.2 36
  • 17 (a)
CU571323.1 36
  • 17 (a)
DARE-ZE*0601 36
  • 18 (a)
mhc1uba 36
  • 20 (a)
mhc1uca 36
  • 20 (a)
mhc1zaa 36
  • 17 (a)
mhc1zaa 36
  • 17 (a)
mhc1zba 36
  • 17 (a)
mhc1zca 36
  • 20 (a)
mhc1zea 36
  • 19 (a)
mhc1zfa 36
  • 19 (a)
si:ch211-147g22.1 36
  • 19 (a)
si:ch211-147g22.2 36
  • 18 (a)
si:ch211-147g22.3 36
  • 19 (a)
si:ch211-147g22.4 36
  • 23 (a)
si:dkey-52p2.4 36
  • 16 (a)
si:dkey-52p2.6 36
  • 18 (a)
si:dkey-52p2.7 36
  • 20 (a)
zgc:113060 36
  • 14 (a)
Species with no ortholog for MICB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MICB Gene

Gene Tree for MICB (if available)
Gene Tree for MICB (if available)

Paralogs for MICB Gene

Paralogs for MICB Gene Pseudogenes for MICB Gene

genes like me logo Genes that share paralogs with MICB: view

Variants for MICB Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for MICB Gene

The following alleles of MICB are known: MICB*001, MICB*002, MICB*003, MICB*004, MICB*005, MICB*006, MICB*007, MICB*008, MICB*009N, MICB*010, MICB*011, MICB*012, MICB*013, MICB*014, MICB*015, MICB*016, MICB*018, MICB*019, MICB*020, MICB*021N and MICB*022. MICB*009N and MICB*021N are null alleles which are not expressed. The sequence shown is that of MICB*001.

Sequence variations from dbSNP and Humsavar for MICB Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs45578846 - 31,505,662(+) GGATG(A/G)ATCTG reference, missense
rs45583740 - 31,505,749(+) AAAGC(A/C)CCAGG reference, missense
rs3131639 - 31,505,769(-) GACAT(C/T)TTCTG reference, missense
rs1065075 - 31,505,784(+) GAGCT(A/G)AGACC reference, missense
rs45486091 - 31,505,809(+) CGAGG(A/G)CTTGA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for MICB Gene

Variant ID Type Subtype PubMed ID
esv690 CNV CNV 17122850
dgv1042e201 CNV Deletion 23290073
dgv1921e1 CNV Complex 17122850
dgv213e55 CNV Gain 17911159
essv13266 CNV CNV 17122850
esv2731822 CNV Deletion 23290073
dgv215e55 CNV Loss 17911159
nsv10821 CNV Loss 18304495
nsv884412 CNV Gain 21882294
nsv884413 CNV Gain 21882294
dgv6580n71 CNV Gain 21882294
dgv1927e1 CNV Complex 17122850
nsv462869 CNV Loss 19166990

Variation tolerance for MICB Gene

Residual Variation Intolerance Score: 71.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.90; 74.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MICB Gene

Human Gene Mutation Database (HGMD)

Disorders for MICB Gene

MalaCards: The human disease database

(6) MalaCards diseases for MICB Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
dengue shock syndrome
  • dss
asymptomatic dengue
behcet's disease
  • adamantiades-behcet disease
celiac disease
  • celiac sprue
rheumatoid arthritis
  • rheumatoid arthritis, progression of
- elite association - COSMIC cancer census association via MalaCards
Search MICB in MalaCards View complete list of genes associated with diseases


  • Note=Genetic variation in MICB is associated with cytomegalovirus and herpes simplex virus I seropositivity and this may be associated with schizophrenia risk.
  • Rheumatoid arthritis (RA) [MIM:180300]: An inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. {ECO:0000269 PubMed:17003176}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. The MICB*004 allele is associated with rheumatoid arthritis.

Relevant External Links for MICB

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with MICB: view

No data available for Genatlas for MICB Gene

Publications for MICB Gene

  1. MHC class I chain-related gene B (MICB) is associated with rheumatoid arthritis susceptibility. (PMID: 17003176) Lopez-Arbesu R. … Gonzalez S. (Rheumatology 2007) 3 4 23 48 67
  2. MICB0106 gene polymorphism is associated with ulcerative colitis in central China. (PMID: 19662431) Li Y. … Zhang X. (Int J Colorectal Dis 2010) 3 23
  3. Genomewide association study of an AIDS-nonprogression cohort emphasizes the role played by HLA genes (ANRS Genomewide Association Study 02). (PMID: 19115949) Limou S. … Zagury J.F. (J. Infect. Dis. 2009) 3 23
  4. Association of MICA-TM and MICB C1_2_A microsatellite polymorphisms with tumor progression in patients with colorectal cancer. (PMID: 19353249) Kopp R. … Weiss E.H. (J. Clin. Immunol. 2009) 3 23
  5. Sequencing-based genotyping and association analysis of the MICA and MICB genes in type 1 diabetes. (PMID: 18332098) Field S.F. … Todd J.A. (Diabetes 2008) 3 23

Products for MICB Gene

Sources for MICB Gene