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Aliases for MICALL2 Gene

Aliases for MICALL2 Gene

  • MICAL-Like 2 2 3
  • Junctional Rab13-Binding Protein 2 3 4
  • Molecule Interacting With CasL-Like 2 3 4
  • MICAL-L2 3 4
  • JRAB 3 4
  • MICAL-Like Protein 2 3

External Ids for MICALL2 Gene

Summaries for MICALL2 Gene

GeneCards Summary for MICALL2 Gene

MICALL2 (MICAL-Like 2) is a Protein Coding gene. GO annotations related to this gene include actin filament binding and filamin binding. An important paralog of this gene is SMTNL2.

UniProtKB/Swiss-Prot for MICALL2 Gene

  • Effector of small Rab GTPases which is involved in junctional complexes assembly through the regulation of cell adhesion molecules transport to the plasma membrane and actin cytoskeleton reorganization. Regulates the endocytic recycling of occludins, claudins and E-cadherin to the plasma membrane and may thereby regulate the establishment of tight junctions and adherens junctions. In parallel, may regulate actin cytoskeleton reorganization directly through interaction with F-actin or indirectly through actinins and filamins. Most probably involved in the processes of epithelial cell differentiation, cell spreading and neurite outgrowth (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MICALL2 Gene

Genomics for MICALL2 Gene

Genomic Location for MICALL2 Gene

Start:
1,428,465 bp from pter
End:
1,459,502 bp from pter
Size:
31,038 bases
Orientation:
Minus strand

Genomic View for MICALL2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MICALL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MICALL2 Gene

Regulatory Elements for MICALL2 Gene

Proteins for MICALL2 Gene

  • Protein details for MICALL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IY33-MILK2_HUMAN
    Recommended name:
    MICAL-like protein 2
    Protein Accession:
    Q8IY33
    Secondary Accessions:
    • D3YTD2
    • Q7RTP4
    • Q7Z655
    • Q8TEQ4
    • Q9H5F9

    Protein attributes for MICALL2 Gene

    Size:
    904 amino acids
    Molecular mass:
    97502 Da
    Quaternary structure:
    • Interacts with RAB13 (GTP-bound form); competes with RAB8A and is involved in tight junctions assembly. Interacts with RAB8A; competes with RAB13 and is involved in E-cadherin endocytic recycling (By similarity). Interacts with RAB8B (By similarity). Interacts (preferentially in opened conformation) with ACTN1 and ACTN4; stimulated by RAB13 activation (By similarity). Interacts (via CH domain) with the filamins FLNA, FLNB and FLNC (via actin-binding domain).
    SequenceCaution:
    • Sequence=BAB15667.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAB84894.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for MICALL2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MICALL2 Gene

Proteomics data for MICALL2 Gene at MOPED

Post-translational modifications for MICALL2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MICALL2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MICALL2 Gene

Domains for MICALL2 Gene

Protein Domains for MICALL2 Gene

Suggested Antigen Peptide Sequences for MICALL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IY33

UniProtKB/Swiss-Prot:

MILK2_HUMAN
Domain:
  • Probably exists in a closed and an opened conformation due to interaction of the C-terminal coiled-coil domain with an N-terminal region including the CH (calponin-homology) and the LIM zinc-binding domain. The conformational change is regulated by RAB13 (By similarity).:
    • Q8IY33
  • Contains 1 CH (calponin-homology) domain.:
    • Q8IY33
  • Contains 1 LIM zinc-binding domain.:
    • Q8IY33
genes like me logo Genes that share domains with MICALL2: view

No data available for Gene Families for MICALL2 Gene

Function for MICALL2 Gene

Molecular function for MICALL2 Gene

UniProtKB/Swiss-Prot Function: Effector of small Rab GTPases which is involved in junctional complexes assembly through the regulation of cell adhesion molecules transport to the plasma membrane and actin cytoskeleton reorganization. Regulates the endocytic recycling of occludins, claudins and E-cadherin to the plasma membrane and may thereby regulate the establishment of tight junctions and adherens junctions. In parallel, may regulate actin cytoskeleton reorganization directly through interaction with F-actin or indirectly through actinins and filamins. Most probably involved in the processes of epithelial cell differentiation, cell spreading and neurite outgrowth (By similarity).

Gene Ontology (GO) - Molecular Function for MICALL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0008270 zinc ion binding IEA --
GO:0017137 Rab GTPase binding IEA --
GO:0031005 filamin binding IDA 23890175
GO:0042805 actinin binding IEA --
genes like me logo Genes that share ontologies with MICALL2: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MICALL2 Gene

Localization for MICALL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MICALL2 Gene

Cell membrane; Peripheral membrane protein. Cell junction, tight junction. Recycling endosome. Cell projection. Cytoplasm, cytoskeleton. Cytoplasm, cytosol.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MICALL2 Gene COMPARTMENTS Subcellular localization image for MICALL2 gene
Compartment Confidence
cytosol 3
nucleus 3
cytoskeleton 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for MICALL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001725 colocalizes_with stress fiber ISS --
GO:0005829 cytosol IEA --
GO:0005886 plasma membrane ISS --
GO:0005911 cell-cell junction ISS --
GO:0005923 bicellular tight junction ISS --
genes like me logo Genes that share ontologies with MICALL2: view

Pathways for MICALL2 Gene

SuperPathways for MICALL2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MICALL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030041 actin filament polymerization ISS --
GO:0031175 neuron projection development ISS --
GO:0031532 actin cytoskeleton reorganization ISS --
GO:0032456 endocytic recycling ISS --
GO:0034333 adherens junction assembly IEA --
genes like me logo Genes that share ontologies with MICALL2: view

No data available for Pathways by source for MICALL2 Gene

Transcripts for MICALL2 Gene

Unigene Clusters for MICALL2 Gene

MICAL-like 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MICALL2 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
SP1: - - - -
SP2: - - -
SP3: - -
SP4: -
SP5: - -
SP6: - -
SP7:

Relevant External Links for MICALL2 Gene

GeneLoc Exon Structure for
MICALL2
ECgene alternative splicing isoforms for
MICALL2

Expression for MICALL2 Gene

mRNA expression in normal human tissues for MICALL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MICALL2 Gene

This gene is overexpressed in Nerve - Tibial (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MICALL2 Gene

SOURCE GeneReport for Unigene cluster for MICALL2 Gene Hs.376617

genes like me logo Genes that share expressions with MICALL2: view

No data available for mRNA Expression by UniProt/SwissProt for MICALL2 Gene

Orthologs for MICALL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for MICALL2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MICALL2 35
  • 74.8 (n)
  • 64.16 (a)
MICALL2 36
  • 62 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MICALL2 35
  • 74.16 (n)
  • 61.57 (a)
MICALL2 36
  • 52 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Micall2 35
  • 70.29 (n)
  • 63.51 (a)
Micall2 16
Micall2 36
  • 54 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MICALL2 36
  • 43 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MICALL2 36
  • 38 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Micall2 35
  • 71.51 (n)
  • 64.54 (a)
chicken
(Gallus gallus)
Aves MICALL2 35
  • 60.5 (n)
  • 55.93 (a)
MICALL2 36
  • 43 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia micall2 35
  • 52.11 (n)
  • 46.86 (a)
zebrafish
(Danio rerio)
Actinopterygii MICALL2 (3 of 3) 36
  • 6 (a)
OneToMany
micall2a 36
  • 37 (a)
OneToMany
micall2b 36
  • 36 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG13366 36
  • 6 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3677 36
  • 7 (a)
OneToMany
Species with no ortholog for MICALL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MICALL2 Gene

ENSEMBL:
Gene Tree for MICALL2 (if available)
TreeFam:
Gene Tree for MICALL2 (if available)

Paralogs for MICALL2 Gene

Selected SIMAP similar genes for MICALL2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MICALL2: view

Variants for MICALL2 Gene

Sequence variations from dbSNP and Humsavar for MICALL2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs1132621 -- 1,449,582(-) CACTG(C/G)CCTGC intron-variant
rs3923842 -- 1,437,302(+) GCTAC(A/G)AGCAT intron-variant
rs4075307 - 1,442,347(-) AGCCC(C/T)GCTGA reference, missense
rs4075308 -- 1,442,169(-) AGGCA(C/G)GAGGC intron-variant
rs4236408 -- 1,442,283(+) GATTC(A/C)GCCAA reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for MICALL2 Gene

Variant ID Type Subtype PubMed ID
nsv887128 CNV Loss 21882294
nsv471182 CNV Loss 18288195
dgv2045e1 CNV Complex 17122850
dgv7088n71 CNV Loss 21882294
dgv7090n71 CNV Loss 21882294
dgv7092n71 CNV Loss 21882294
dgv7093n71 CNV Loss 21882294
nsv887184 CNV Loss 21882294
nsv830878 CNV Loss 17160897
dgv7094n71 CNV Loss 21882294
dgv7095n71 CNV Loss 21882294
dgv7096n71 CNV Loss 21882294
nsv521100 CNV Loss 19592680
nsv464247 CNV Loss 19166990
dgv7097n71 CNV Loss 21882294
dgv7098n71 CNV Loss 21882294
nsv823970 CNV Gain 20364138
nsv887213 CNV Loss 21882294
esv2733763 CNV Deletion 23290073
nsv8029 CNV Gain+Loss 18304495
esv2672441 CNV Deletion 23128226

Relevant External Links for MICALL2 Gene

HapMap Linkage Disequilibrium report
MICALL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MICALL2 Gene

Disorders for MICALL2 Gene

No disorders were found for MICALL2 Gene.

No data available for UniProtKB/Swiss-Prot for MICALL2 Gene

Publications for MICALL2 Gene

  1. MICALs, a family of conserved flavoprotein oxidoreductases, function in plexin-mediated axonal repulsion. (PMID: 12110185) Terman J.R. … Kolodkin A.L. (Cell 2002) 2 3 4
  2. JRAB/MICAL-L2 is a junctional Rab13-binding protein mediating the endocytic recycling of occludin. (PMID: 16525024) Terai T. … Sasaki T. (Mol. Biol. Cell 2006) 2 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Junctional Rab13-binding protein (JRAB) regulates cell spreading via filamins. (PMID: 23890175) Sakane A. … Sasaki T. (Genes Cells 2013) 3 4

Products for MICALL2 Gene

Sources for MICALL2 Gene

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