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Aliases for MICALL2 Gene

Aliases for MICALL2 Gene

  • MICAL Like 2 2 3
  • Junctional Rab13-Binding Protein 2 3 4
  • Molecule Interacting With CasL-Like 2 3 4
  • MICAL-Like 2 3 5
  • MICAL-L2 3 4
  • JRAB 3 4

External Ids for MICALL2 Gene

Summaries for MICALL2 Gene

GeneCards Summary for MICALL2 Gene

MICALL2 (MICAL Like 2) is a Protein Coding gene. GO annotations related to this gene include actin filament binding and filamin binding. An important paralog of this gene is SMTNL2.

UniProtKB/Swiss-Prot for MICALL2 Gene

  • Effector of small Rab GTPases which is involved in junctional complexes assembly through the regulation of cell adhesion molecules transport to the plasma membrane and actin cytoskeleton reorganization. Regulates the endocytic recycling of occludins, claudins and E-cadherin to the plasma membrane and may thereby regulate the establishment of tight junctions and adherens junctions. In parallel, may regulate actin cytoskeleton reorganization directly through interaction with F-actin or indirectly through actinins and filamins. Most probably involved in the processes of epithelial cell differentiation, cell spreading and neurite outgrowth (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MICALL2 Gene

Genomics for MICALL2 Gene

Regulatory Elements for MICALL2 Gene

Promoters for MICALL2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MICALL2 on UCSC Golden Path with GeneCards custom track

Genomic Location for MICALL2 Gene

Chromosome:
7
Start:
1,428,465 bp from pter
End:
1,459,502 bp from pter
Size:
31,038 bases
Orientation:
Minus strand

Genomic View for MICALL2 Gene

Genes around MICALL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MICALL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MICALL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MICALL2 Gene

Proteins for MICALL2 Gene

  • Protein details for MICALL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IY33-MILK2_HUMAN
    Recommended name:
    MICAL-like protein 2
    Protein Accession:
    Q8IY33
    Secondary Accessions:
    • D3YTD2
    • Q7RTP4
    • Q7Z655
    • Q8TEQ4
    • Q9H5F9

    Protein attributes for MICALL2 Gene

    Size:
    904 amino acids
    Molecular mass:
    97502 Da
    Quaternary structure:
    • Interacts with RAB13 (GTP-bound form); competes with RAB8A and is involved in tight junctions assembly. Interacts with RAB8A; competes with RAB13 and is involved in E-cadherin endocytic recycling (By similarity). Interacts with RAB8B (By similarity). Interacts (preferentially in opened conformation) with ACTN1 and ACTN4; stimulated by RAB13 activation (By similarity). Interacts (via CH domain) with the filamins FLNA, FLNB and FLNC (via actin-binding domain).
    SequenceCaution:
    • Sequence=BAB15667.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAB84894.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for MICALL2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MICALL2 Gene

Proteomics data for MICALL2 Gene at MOPED

Post-translational modifications for MICALL2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MICALL2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for MICALL2 Gene

Domains & Families for MICALL2 Gene

Gene Families for MICALL2 Gene

Protein Domains for MICALL2 Gene

Suggested Antigen Peptide Sequences for MICALL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IY33

UniProtKB/Swiss-Prot:

MILK2_HUMAN :
  • Probably exists in a closed and an opened conformation due to interaction of the C-terminal coiled-coil domain with an N-terminal region including the CH (calponin-homology) and the LIM zinc-binding domain. The conformational change is regulated by RAB13 (By similarity).
Domain:
  • Probably exists in a closed and an opened conformation due to interaction of the C-terminal coiled-coil domain with an N-terminal region including the CH (calponin-homology) and the LIM zinc-binding domain. The conformational change is regulated by RAB13 (By similarity).
  • Contains 1 CH (calponin-homology) domain.
  • Contains 1 LIM zinc-binding domain.
genes like me logo Genes that share domains with MICALL2: view

Function for MICALL2 Gene

Molecular function for MICALL2 Gene

UniProtKB/Swiss-Prot Function:
Effector of small Rab GTPases which is involved in junctional complexes assembly through the regulation of cell adhesion molecules transport to the plasma membrane and actin cytoskeleton reorganization. Regulates the endocytic recycling of occludins, claudins and E-cadherin to the plasma membrane and may thereby regulate the establishment of tight junctions and adherens junctions. In parallel, may regulate actin cytoskeleton reorganization directly through interaction with F-actin or indirectly through actinins and filamins. Most probably involved in the processes of epithelial cell differentiation, cell spreading and neurite outgrowth (By similarity).

Gene Ontology (GO) - Molecular Function for MICALL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0017137 Rab GTPase binding IEA --
GO:0051015 actin filament binding IEA,ISS --
genes like me logo Genes that share ontologies with MICALL2: view
genes like me logo Genes that share phenotypes with MICALL2: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MICALL2 Gene

Localization for MICALL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MICALL2 Gene

Cell membrane; Peripheral membrane protein. Cell junction, tight junction. Recycling endosome. Cell projection. Cytoplasm, cytoskeleton. Cytoplasm, cytosol.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MICALL2 Gene COMPARTMENTS Subcellular localization image for MICALL2 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 4
cytosol 4
endosome 4
nucleus 4

Gene Ontology (GO) - Cellular Components for MICALL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001725 colocalizes_with stress fiber ISS --
GO:0005911 cell-cell junction IEA,ISS --
GO:0032432 colocalizes_with actin filament bundle IEA,ISS --
genes like me logo Genes that share ontologies with MICALL2: view

Pathways & Interactions for MICALL2 Gene

SuperPathways for MICALL2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MICALL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030041 actin filament polymerization IEA,ISS --
GO:0070830 bicellular tight junction assembly IEA,ISS --
GO:1903955 positive regulation of protein targeting to mitochondrion IMP 24270810
genes like me logo Genes that share ontologies with MICALL2: view

No data available for Pathways by source and SIGNOR curated interactions for MICALL2 Gene

Drugs & Compounds for MICALL2 Gene

No Compound Related Data Available

Transcripts for MICALL2 Gene

Unigene Clusters for MICALL2 Gene

MICAL-like 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MICALL2 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
SP1: - - - -
SP2: - - -
SP3: - -
SP4: -
SP5: - -
SP6: - -
SP7:

Relevant External Links for MICALL2 Gene

GeneLoc Exon Structure for
MICALL2
ECgene alternative splicing isoforms for
MICALL2

Expression for MICALL2 Gene

mRNA expression in normal human tissues for MICALL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MICALL2 Gene

This gene is overexpressed in Nerve - Tibial (x4.2).

Protein differential expression in normal tissues from HIPED for MICALL2 Gene

This gene is overexpressed in Pancreas (52.4) and Peripheral blood mononuclear cells (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MICALL2 Gene



SOURCE GeneReport for Unigene cluster for MICALL2 Gene Hs.376617

genes like me logo Genes that share expression patterns with MICALL2: view

Protein tissue co-expression partners for MICALL2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for MICALL2 Gene

Orthologs for MICALL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for MICALL2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MICALL2 36
  • 62 (a)
OneToOne
MICALL2 35
  • 74.8 (n)
  • 64.16 (a)
dog
(Canis familiaris)
Mammalia MICALL2 35
  • 74.16 (n)
  • 61.57 (a)
MICALL2 36
  • 52 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Micall2 16
Micall2 35
  • 70.29 (n)
  • 63.51 (a)
Micall2 36
  • 54 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MICALL2 36
  • 43 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MICALL2 36
  • 38 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Micall2 35
  • 71.51 (n)
  • 64.54 (a)
chicken
(Gallus gallus)
Aves MICALL2 35
  • 60.5 (n)
  • 55.93 (a)
MICALL2 36
  • 43 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia micall2 35
  • 52.11 (n)
  • 46.86 (a)
zebrafish
(Danio rerio)
Actinopterygii MICALL2 (3 of 3) 36
  • 6 (a)
OneToMany
micall2a 36
  • 37 (a)
OneToMany
micall2b 36
  • 36 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG13366 36
  • 6 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3677 36
  • 7 (a)
OneToMany
Species with no ortholog for MICALL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MICALL2 Gene

ENSEMBL:
Gene Tree for MICALL2 (if available)
TreeFam:
Gene Tree for MICALL2 (if available)

Paralogs for MICALL2 Gene

(2) SIMAP similar genes for MICALL2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MICALL2: view

Variants for MICALL2 Gene

Sequence variations from dbSNP and Humsavar for MICALL2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs12540098 - 1,442,465(+) AACAG(C/G/T)GGCAG nc-transcript-variant, upstream-variant-2KB, reference, missense
rs4075307 - 1,442,347(-) AGCCC(C/T)GCTGA nc-transcript-variant, upstream-variant-2KB, reference, missense
rs11980797 - 1,438,345(+) GGACA(A/C)GGGTC nc-transcript-variant, reference, missense
rs61287564 - 1,440,023(+) AGACC(C/T)TCCTG nc-transcript-variant, reference, missense
rs1132621 -- 1,449,582(-) CACTG(C/G)CCTGC intron-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for MICALL2 Gene

Variant ID Type Subtype PubMed ID
nsv887128 CNV Loss 21882294
nsv471182 CNV Loss 18288195
dgv2045e1 CNV Complex 17122850
dgv7088n71 CNV Loss 21882294
dgv7090n71 CNV Loss 21882294
dgv7092n71 CNV Loss 21882294
dgv7093n71 CNV Loss 21882294
nsv887184 CNV Loss 21882294
nsv830878 CNV Loss 17160897
dgv7094n71 CNV Loss 21882294
dgv7095n71 CNV Loss 21882294
dgv7096n71 CNV Loss 21882294
nsv521100 CNV Loss 19592680
nsv464247 CNV Loss 19166990
dgv7097n71 CNV Loss 21882294
dgv7098n71 CNV Loss 21882294
nsv823970 CNV Gain 20364138
nsv887213 CNV Loss 21882294
esv2733763 CNV Deletion 23290073
nsv8029 CNV Gain+Loss 18304495
esv2672441 CNV Deletion 23128226

Variation tolerance for MICALL2 Gene

Residual Variation Intolerance Score: 99.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.86; 74.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MICALL2 Gene

HapMap Linkage Disequilibrium report
MICALL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MICALL2 Gene

Disorders for MICALL2 Gene

Relevant External Links for MICALL2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MICALL2

No disorders were found for MICALL2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MICALL2 Gene

Publications for MICALL2 Gene

  1. JRAB/MICAL-L2 is a junctional Rab13-binding protein mediating the endocytic recycling of occludin. (PMID: 16525024) Terai T. … Sasaki T. (Mol. Biol. Cell 2006) 2 3 4 67
  2. MICALs, a family of conserved flavoprotein oxidoreductases, function in plexin-mediated axonal repulsion. (PMID: 12110185) Terman J.R. … Kolodkin A.L. (Cell 2002) 2 3
  3. Silencing of MICAL-L2 suppresses malignancy of ovarian cancer by inducing mesenchymal-epithelial transition. (PMID: 25864591) Zhu L.Y. … Zhang Z.G. (Cancer Lett. 2015) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy. (PMID: 24270810) Hasson S.A. … Youle R.J. (Nature 2013) 3

Products for MICALL2 Gene

Sources for MICALL2 Gene

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