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Aliases for MICALL2 Gene

Aliases for MICALL2 Gene

  • MICAL Like 2 2 3 5
  • Junctional Rab13-Binding Protein 2 3 4
  • Molecule Interacting With CasL-Like 2 3 4
  • MICAL-L2 3 4
  • JRAB 3 4
  • MICAL-Like Protein 2 3

External Ids for MICALL2 Gene

Summaries for MICALL2 Gene

GeneCards Summary for MICALL2 Gene

MICALL2 (MICAL Like 2) is a Protein Coding gene. GO annotations related to this gene include actin filament binding and filamin binding. An important paralog of this gene is MICALL1.

UniProtKB/Swiss-Prot for MICALL2 Gene

  • Effector of small Rab GTPases which is involved in junctional complexes assembly through the regulation of cell adhesion molecules transport to the plasma membrane and actin cytoskeleton reorganization. Regulates the endocytic recycling of occludins, claudins and E-cadherin to the plasma membrane and may thereby regulate the establishment of tight junctions and adherens junctions. In parallel, may regulate actin cytoskeleton reorganization directly through interaction with F-actin or indirectly through actinins and filamins. Most probably involved in the processes of epithelial cell differentiation, cell spreading and neurite outgrowth (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MICALL2 Gene

Genomics for MICALL2 Gene

Regulatory Elements for MICALL2 Gene

Enhancers for MICALL2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F001432 0.2 Ensembl 8.3 +26.8 26802 0.6 BCOR CTCF EBF1 ZNF48 ZIC2 RAD21 SCRT2 ZNF143 SMC3 CREM MICALL2 ENSG00000233082
GH07F001417 0.7 Ensembl ENCODE 7.5 +41.5 41534 1.5 HDGF ATF1 SIN3A ARID4B FOS SP3 SP5 NCOA1 JUNB TBX21 CHST12 MICALL2 ENSG00000233082
GH07F002279 0.9 Ensembl ENCODE 6.6 -821.6 -821641 3.7 CTCF HDAC1 TBL1XR1 TAL1 UBTF ZNF384 TEAD3 ZNF121 POLR2A GATA2 SNX8 MICALL2 IMMP1LP3 GC07P002270
GH07F001411 1 Ensembl ENCODE 5.7 +46.8 46810 1.7 ATF1 SIN3A ZNF48 RAD21 SCRT2 ZNF143 CREM KLF13 ZNF263 ZNF654 MICALL2 ENSG00000233082
GH07F001473 0.2 ENCODE 5.3 -14.9 -14878 1.4 HDGF ATF1 PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF48 ZNF2 ZNF121 MICALL2 GC07M001472 ENSG00000273230
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MICALL2 on UCSC Golden Path with GeneCards custom track

Promoters for MICALL2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001556819 302 2401 HDGF ATF1 ARID4B SIN3A ZNF48 GLIS2 FOS SP3 YY2 SP5
ENSR00001888504 -1598 201 HDGF ATF1 ARNT ARID4B ZNF48 CBX5 ELK1 JUNB MEF2D SMARCA4

Genomic Location for MICALL2 Gene

Chromosome:
7
Start:
1,428,465 bp from pter
End:
1,459,502 bp from pter
Size:
31,038 bases
Orientation:
Minus strand

Genomic View for MICALL2 Gene

Genes around MICALL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MICALL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MICALL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MICALL2 Gene

Proteins for MICALL2 Gene

  • Protein details for MICALL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IY33-MILK2_HUMAN
    Recommended name:
    MICAL-like protein 2
    Protein Accession:
    Q8IY33
    Secondary Accessions:
    • D3YTD2
    • Q7RTP4
    • Q7Z655
    • Q8TEQ4
    • Q9H5F9

    Protein attributes for MICALL2 Gene

    Size:
    904 amino acids
    Molecular mass:
    97502 Da
    Quaternary structure:
    • Interacts with RAB13 (GTP-bound form); competes with RAB8A and is involved in tight junctions assembly. Interacts with RAB8A; competes with RAB13 and is involved in E-cadherin endocytic recycling (By similarity). Interacts with RAB8B (By similarity). Interacts (preferentially in opened conformation) with ACTN1 and ACTN4; stimulated by RAB13 activation (By similarity). Interacts (via CH domain) with the filamins FLNA, FLNB and FLNC (via actin-binding domain).
    SequenceCaution:
    • Sequence=BAB15667.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAB84894.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for MICALL2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MICALL2 Gene

Post-translational modifications for MICALL2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MICALL2 Gene

Antibody Products

  • Abcam antibodies for MICALL2

No data available for DME Specific Peptides for MICALL2 Gene

Domains & Families for MICALL2 Gene

Gene Families for MICALL2 Gene

Protein Domains for MICALL2 Gene

Suggested Antigen Peptide Sequences for MICALL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IY33

UniProtKB/Swiss-Prot:

MILK2_HUMAN :
  • Probably exists in a closed and an opened conformation due to interaction of the C-terminal coiled-coil domain with an N-terminal region including the CH (calponin-homology) and the LIM zinc-binding domain. The conformational change is regulated by RAB13 (By similarity).
Domain:
  • Probably exists in a closed and an opened conformation due to interaction of the C-terminal coiled-coil domain with an N-terminal region including the CH (calponin-homology) and the LIM zinc-binding domain. The conformational change is regulated by RAB13 (By similarity).
  • Contains 1 CH (calponin-homology) domain.
  • Contains 1 LIM zinc-binding domain.
genes like me logo Genes that share domains with MICALL2: view

Function for MICALL2 Gene

Molecular function for MICALL2 Gene

UniProtKB/Swiss-Prot Function:
Effector of small Rab GTPases which is involved in junctional complexes assembly through the regulation of cell adhesion molecules transport to the plasma membrane and actin cytoskeleton reorganization. Regulates the endocytic recycling of occludins, claudins and E-cadherin to the plasma membrane and may thereby regulate the establishment of tight junctions and adherens junctions. In parallel, may regulate actin cytoskeleton reorganization directly through interaction with F-actin or indirectly through actinins and filamins. Most probably involved in the processes of epithelial cell differentiation, cell spreading and neurite outgrowth (By similarity).

Gene Ontology (GO) - Molecular Function for MICALL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0008270 zinc ion binding IEA --
GO:0017137 Rab GTPase binding IEA --
GO:0031005 filamin binding IDA 23890175
GO:0042805 actinin binding IEA --
genes like me logo Genes that share ontologies with MICALL2: view
genes like me logo Genes that share phenotypes with MICALL2: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MICALL2 Gene

Localization for MICALL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MICALL2 Gene

Cell membrane; Peripheral membrane protein. Cell junction, tight junction. Recycling endosome. Cell projection. Cytoplasm, cytoskeleton. Cytoplasm, cytosol.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MICALL2 Gene COMPARTMENTS Subcellular localization image for MICALL2 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 4
cytosol 4
endosome 4
nucleus 4

Gene Ontology (GO) - Cellular Components for MICALL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001725 colocalizes_with stress fiber ISS --
GO:0005737 cytoplasm IEA --
GO:0005768 endosome IEA --
GO:0005829 cytosol IEA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with MICALL2: view

Pathways & Interactions for MICALL2 Gene

SuperPathways for MICALL2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MICALL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030041 actin filament polymerization IEA,ISS --
GO:0031175 neuron projection development IEA,ISS --
GO:0031532 actin cytoskeleton reorganization IEA,ISS --
GO:0032456 endocytic recycling IEA,ISS --
GO:0034446 substrate adhesion-dependent cell spreading IEA,ISS --
genes like me logo Genes that share ontologies with MICALL2: view

No data available for Pathways by source and SIGNOR curated interactions for MICALL2 Gene

Transcripts for MICALL2 Gene

Unigene Clusters for MICALL2 Gene

MICAL-like 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MICALL2 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
SP1: - - - -
SP2: - - -
SP3: - -
SP4: -
SP5: - -
SP6: - -
SP7:

Relevant External Links for MICALL2 Gene

GeneLoc Exon Structure for
MICALL2
ECgene alternative splicing isoforms for
MICALL2

Expression for MICALL2 Gene

mRNA expression in normal human tissues for MICALL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MICALL2 Gene

This gene is overexpressed in Nerve - Tibial (x4.2).

Protein differential expression in normal tissues from HIPED for MICALL2 Gene

This gene is overexpressed in Pancreas (52.4) and Peripheral blood mononuclear cells (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MICALL2 Gene



Protein tissue co-expression partners for MICALL2 Gene

NURSA nuclear receptor signaling pathways regulating expression of MICALL2 Gene:

MICALL2

SOURCE GeneReport for Unigene cluster for MICALL2 Gene:

Hs.376617
genes like me logo Genes that share expression patterns with MICALL2: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for MICALL2 Gene

Orthologs for MICALL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for MICALL2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MICALL2 34 35
  • 74.8 (n)
dog
(Canis familiaris)
Mammalia MICALL2 34 35
  • 74.16 (n)
rat
(Rattus norvegicus)
Mammalia Micall2 34
  • 71.51 (n)
mouse
(Mus musculus)
Mammalia Micall2 34 16 35
  • 70.29 (n)
oppossum
(Monodelphis domestica)
Mammalia MICALL2 35
  • 43 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MICALL2 35
  • 38 (a)
OneToOne
chicken
(Gallus gallus)
Aves MICALL2 34 35
  • 60.5 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia micall2 34
  • 52.11 (n)
zebrafish
(Danio rerio)
Actinopterygii micall2a 35
  • 37 (a)
OneToMany
micall2b 35
  • 36 (a)
OneToMany
MICALL2 (3 of 3) 35
  • 6 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG13366 35
  • 6 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3677 35
  • 7 (a)
OneToMany
Species where no ortholog for MICALL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MICALL2 Gene

ENSEMBL:
Gene Tree for MICALL2 (if available)
TreeFam:
Gene Tree for MICALL2 (if available)

Paralogs for MICALL2 Gene

(2) SIMAP similar genes for MICALL2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MICALL2: view

Variants for MICALL2 Gene

Sequence variations from dbSNP and Humsavar for MICALL2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs10226521 -- 1,449,593(+) CCGGC(C/T)GGGCA intron-variant
rs10229642 -- 1,458,126(+) CTCAA(A/G)ACCCC intron-variant, upstream-variant-2KB
rs10232735 -- 1,455,992(+) GACTA(C/T)TGGGG intron-variant, upstream-variant-2KB
rs10237702 -- 1,459,904(+) acgcc(A/G)cctgg nc-transcript-variant, upstream-variant-2KB
rs10238356 -- 1,455,880(+) AGGGG(A/C)ATGAG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MICALL2 Gene

Variant ID Type Subtype PubMed ID
dgv11135n54 CNV loss 21841781
esv2672441 CNV deletion 23128226
esv2733763 CNV deletion 23290073
esv2759499 CNV loss 17122850
esv3330014 CNV duplication 20981092
esv3541026 CNV deletion 23714750
esv3611808 CNV loss 21293372
nsv1017606 CNV loss 25217958
nsv1074058 CNV deletion 25765185
nsv1126768 CNV deletion 24896259
nsv464247 CNV loss 19166990
nsv471182 CNV loss 18288195
nsv521100 CNV loss 19592680
nsv605813 CNV loss 21841781
nsv605816 CNV loss 21841781
nsv605817 CNV loss 21841781
nsv8029 CNV gain+loss 18304495
nsv823970 CNV gain 20364138
nsv830878 CNV loss 17160897
nsv950786 CNV deletion 24416366

Variation tolerance for MICALL2 Gene

Residual Variation Intolerance Score: 99.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.86; 74.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MICALL2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MICALL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MICALL2 Gene

Disorders for MICALL2 Gene

Relevant External Links for MICALL2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MICALL2

No disorders were found for MICALL2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MICALL2 Gene

Publications for MICALL2 Gene

  1. JRAB/MICAL-L2 is a junctional Rab13-binding protein mediating the endocytic recycling of occludin. (PMID: 16525024) Terai T. … Sasaki T. (Mol. Biol. Cell 2006) 2 3 4 64
  2. MICALs, a family of conserved flavoprotein oxidoreductases, function in plexin-mediated axonal repulsion. (PMID: 12110185) Terman J.R. … Kolodkin A.L. (Cell 2002) 2 3 4 64
  3. Junctional Rab13-binding protein (JRAB) regulates cell spreading via filamins. (PMID: 23890175) Sakane A. … Sasaki T. (Genes Cells 2013) 3 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for MICALL2 Gene

Sources for MICALL2 Gene

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