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MICALL2 Gene

protein-coding   GIFtS: 47
GCID: GC07M001441

MICAL-Like 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
MICAL-Like 21 2
Junctional Rab13-Binding Protein1 2 3
Molecule Interacting With CasL-Like 22 3
JRAB2 3
MICAL-L22 3
MICAL-Like Protein 22

External Ids:    HGNC: 296721   Entrez Gene: 797782   Ensembl: ENSG000001648777   UniProtKB: Q8IY333   

Export aliases for MICALL2 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MICALL2 Gene:
MICALL2 (MICAL-like 2) is a protein-coding gene. Diseases associated with MICALL2 include juvenile rheumatoid arthritis, and rheumatoid arthritis. GO annotations related to this gene include filamin binding and actin filament binding. An important paralog of this gene is MICAL2.

UniProtKB/Swiss-Prot: MILK2_HUMAN, Q8IY33
Function: Effector of small Rab GTPases which is involved in junctional complexes assembly through the regulation
of cell adhesion molecules transport to the plasma membrane and actin cytoskeleton reorganization. Regulates the
endocytic recycling of occludins, claudins and E-cadherin to the plasma membrane and may thereby regulate the
establishment of tight junctions and adherens junctions. In parallel, may regulate actin cytoskeleton
reorganization directly through interaction with F-actin or indirectly through actinins and filamins. Most
probably involved in the processes of epithelial cell differentiation, cell spreading and neurite outgrowth (By
similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000007.14  NT_007819.18  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MICALL2 gene promoter:
         GR   USF1   Pax-5   GR-beta   PPAR-gamma1   USF-1   Zic1   STAT3   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): MICALL2 promoter sequence
   Search Chromatin IP Primers for MICALL2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MICALL2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p22.3   Ensembl cytogenetic band:  7p22.3   HGNC cytogenetic band: 7p22.3

MICALL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MICALL2 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M001441:  view genomic region     (about GC identifiers)

Start:
1,468,101 bp from pter      End:
1,499,138 bp from pter
Size:
31,038 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 1,526,339-1,551,457     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: MILK2_HUMAN, Q8IY33 (See protein sequence)
Recommended Name: MICAL-like protein 2  
Size: 904 amino acids; 97502 Da
Subunit: Interacts with RAB13 (GTP-bound form); competes with RAB8A and is involved in tight junctions assembly.
Interacts with RAB8A; competes with RAB13 and is involved in E-cadherin endocytic recycling (By similarity).
Interacts with RAB8B (By similarity). Interacts (preferentially in opened conformation) with ACTN1 and ACTN4;
stimulated by RAB13 activation (By similarity). Interacts (via CH domain) with the filamins FLNA, FLNB and FLNC
(via actin-binding domain)
Sequence caution: Sequence=BAB15667.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=BAB84894.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: D3YTD2 Q7RTP4 Q7Z655 Q8TEQ4 Q9H5F9
Alternative splicing: 5 isoforms:  Q8IY33-1   Q8IY33-2   Q8IY33-3   Q8IY33-4   Q8IY33-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MICALL2: NX_Q8IY33

Explore proteomics data for MICALL2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MICALL2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_891554.1  
    ENSEMBL proteins: 
     ENSP00000405415   ENSP00000297508   ENSP00000385928  

    MICALL2 Human Recombinant Protein Products:

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    MICALL2 Assay Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR022735 DUF3585
     IPR001715 CH-domain
     IPR001781 Znf_LIM

    Graphical View of Domain Structure for InterPro Entry Q8IY33

    ProtoNet protein and cluster: Q8IY33

    2 Blocks protein domains:
    IPB001715 Calponin-like actin-binding
    IPB001781 Zn-binding protein


    UniProtKB/Swiss-Prot: MILK2_HUMAN, Q8IY33
    Domain: Probably exists in a closed and an opened conformation due to interaction of the C-terminal coiled-coil
    domain with an N-terminal region including the CH (calponin-homology) and the LIM zinc-binding domain. The
    conformational change is regulated by RAB13 (By similarity)
    Similarity: Contains 1 CH (calponin-homology) domain
    Similarity: Contains 1 LIM zinc-binding domain


    MICALL2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MILK2_HUMAN, Q8IY33
    Function: Effector of small Rab GTPases which is involved in junctional complexes assembly through the regulation
    of cell adhesion molecules transport to the plasma membrane and actin cytoskeleton reorganization. Regulates the
    endocytic recycling of occludins, claudins and E-cadherin to the plasma membrane and may thereby regulate the
    establishment of tight junctions and adherens junctions. In parallel, may regulate actin cytoskeleton
    reorganization directly through interaction with F-actin or indirectly through actinins and filamins. Most
    probably involved in the processes of epithelial cell differentiation, cell spreading and neurite outgrowth (By
    similarity)

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
    GO:0017137Rab GTPase binding IEA--
    GO:0031005filamin binding IDA--
    GO:0042805actinin binding IEA--
         
    MICALL2 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MICALL2
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    Predesigned siRNA for gene silencing in human, mouse, rat MICALL2

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    GenScript: all cDNA clones in your preferred vector: MICALL2 (NM_182924)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MICALL2

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MILK2_HUMAN, Q8IY33: Cell membrane; Peripheral membrane protein (By similarity). Cell junction, tight junction
    (By similarity). Recycling endosome (By similarity). Cell projection (By similarity). Cytoplasm, cytoskeleton (By
    similarity). Cytoplasm, cytosol (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus3
    cytoskeleton2
    plasma membrane1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001725colocalizes with stress fiber ISS--
    GO:0005829cytosol IEA--
    GO:0005886plasma membrane ISS--
    GO:0005911cell-cell junction ISS--
    GO:0005923tight junction ISS--

    MICALL2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MICALL2
    Interactions:

        GeneGlobe Interaction Network for MICALL2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    Selected Interacting proteins for MICALL2 (Q8IY333 ENSP000002975084) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
    ACTN4ENSP000002526994STRING: ENSP00000252699
    ACTBENSP000003499604STRING: ENSP00000349960
    ACTG1ENSP000003315144STRING: ENSP00000331514
    CAPZA1ENSP000002631684STRING: ENSP00000263168
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006897endocytosis ----
    GO:0030041actin filament polymerization ISS--
    GO:0031175neuron projection development ISS--
    GO:0031532actin cytoskeleton reorganization ISS--
    GO:0032456endocytic recycling ISS--

    MICALL2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MICALL2 (MILK2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MICALL2 gene (2 alternative transcripts): 
    NM_024723.1  NM_182924.3  

    Unigene Clusters for MICALL2:

    MICAL-like 2
    Hs.376617  [show with all ESTs], Hs.663699  [show with all ESTs]
    Unigene Representative Sequences: NM_182924, AK127339
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000493998 ENST00000496184 ENST00000472100(uc003ski.4) ENST00000467783
    ENST00000467394 ENST00000470807 ENST00000471899 ENST00000479007 ENST00000413446
    ENST00000297508(uc003skj.4) ENST00000487187 ENST00000460198 ENST00000487156
    ENST00000482839 ENST00000490608 ENST00000405088
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MICALL2 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate MICALL2
    SwitchGear 3'UTR luciferase reporter plasmidMICALL2 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for MICALL2
    Predesigned siRNA for gene silencing in human, mouse, rat MICALL2
    Clone
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    GenScript: all cDNA clones in your preferred vector: MICALL2 (NM_182924)
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    Primer
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    OriGene qPCR primer pairs and template standards for MICALL2
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MICALL2
      QuantiTect SYBR Green Assays in human, mouse, rat MICALL2
      QuantiFast Probe-based Assays in human, mouse, rat MICALL2

    Additional mRNA sequence: 

    AK123990.1 AK127339.1 

    13 DOTS entries:

    DT.92419474  DT.100766764  DT.101978874  DT.100008370  DT.100766765  DT.91940760  DT.101981278  DT.442915 
    DT.100691433  DT.40240544  DT.40279907  DT.100766766  DT.40211239 

    Selected AceView cDNA sequences (see all 124):

    AY358755 BQ721122 BU738503 AI337658 CR607234 BF800702 AK126808 BM831402 
    AK123990 N92206 BU684046 CK819420 AK091986 AI423119 AI472827 AA331016 
    BG942166 BM822863 BM821523 AW134624 BQ686569 BM832126 BQ575275 AX747292 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MICALL2 (see all 7)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
    SP1:        -                                         -                 -                 -                                                   
    SP2:                                                  -                 -                 -                                                   
    SP3:                                                                    -                 -                                                   
    SP4:                                                                                      -                                                   
    SP5:                                                                                      -                                   -               


    ECgene alternative splicing isoforms for MICALL2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MICALL2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCCCGGAAA
    MICALL2 Expression
    About this image


    MICALL2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             Proerythroblasts Hematopoietic Bone Marrow
     
     Yolk Sac (Extraembryonic Tissues)
             Definitive Hematopoietic Stem Cells Definitive Yolk Sac
     
     Spleen (Hematopoietic System)
    MICALL2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MICALL2 Protein Expression

    SOURCE GeneReport for Unigene clusters: Hs.376617 Hs.663699
        Custom PCR Arrays for MICALL2
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    QuantiFast Probe-based Assays in human, mouse, rat MICALL2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MICALL2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MICALL2 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Micall21 , 5 MICAL-like 21, 5 70.29(n)1
    63.51(a)1
      5 (78.79 cM)5
    2318301  NM_174850.31  NP_777275.21 
     1397066935 
    chicken
    (Gallus gallus)
    Aves MICALL21 MICAL-like 2 60.5(n)
    55.93(a)
      416460  XM_004945133.1  XP_004945190.1 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia micall21 MICAL-like 2 52.11(n)
    46.86(a)
      779968  NM_001079045.1  NP_001072513.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC052767.12   -- 76.45(n)    BC052767.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG133666
    --
    6(a)
    1 → many
    X(504579-514228)


    ENSEMBL Gene Tree for MICALL2 (if available)
    TreeFam Gene Tree for MICALL2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MICALL2 gene
    MICAL22  EHBP12  MICAL32  SPECC12  SMTNL22  MICALL12  MICALCL2  MICAL12  
    SPECC1L-ADORA2A2  SMTN2  EHBP1L12  SPECC1L2  SMTNL12  
    2 SIMAP similar genes for MICALL2 using alignment to 1 protein entry:     MILK2_HUMAN:
    CRIP1    MICALL1

    MICALL2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MICALL2 (see all 1017)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1914427581,2
    --1473499(+) AACAGC/TGCAGC 1 -- int10--------
    rs1828182591,2
    --1473500(+) ACAGCA/GCAGCA 1 -- int10--------
    rs1474941071,2
    C--1473660(+) CAGGAA/GGTCTC 1 -- int10--------
    rs1382917641,2
    --1473684(+) CACTGC/TTTACA 1 -- int10--------
    rs1859400161,2
    --1473753(+) ACATGA/GCGACC 1 -- int10--------
    rs1905999841,2
    --1473845(+) GCCCAC/TCTTCG 1 -- int10--------
    rs1828258151,2
    C--1473859(+) GCCAGA/GCCCTG 1 -- int10--------
    rs624352981,2
    C,F--1473873(+) GGGTCG/AGCTCC 1 -- int11Minor allele frequency- A:0.50NA 2
    rs1506894371,2
    --1473923(+) GCTGGA/GAGGCA 1 -- int10--------
    rs1879098831,2
    --1473926(+) GGGAGA/GCAGGC 1 -- int10--------

    HapMap Linkage Disequilibrium report for MICALL2 (1468101 - 1499138 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for MICALL2 (see all 21):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2733763CNV Deletion23290073
    esv2672441CNV Deletion23128226
    dgv7098n71CNV Loss21882294
    nsv464247CNV Loss19166990
    dgv7092n71CNV Loss21882294
    nsv887128CNV Loss21882294
    nsv887184CNV Loss21882294
    dgv7097n71CNV Loss21882294
    nsv830878CNV Loss17160897
    dgv7094n71CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    4 diseases for MICALL2:    
    About MalaCards
    juvenile rheumatoid arthritis    rheumatoid arthritis    arthritis    neuronitis


    MICALL2 for disorders           About GeneDecksing


    Export disorders for MICALL2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MICALL2 gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with MICALL2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. JRAB/MICAL-L2 is a junctional Rab13-binding protein mediating the endocytic recycling of occludin. (PubMed id 16525024)1, 2, 3 Terai T....Sasaki T. (Mol. Biol. Cell 2006)
    2. MICALs, a family of conserved flavoprotein oxidoreductases, function in plexin-mediated axonal repulsion. (PubMed id 12110185)1, 2, 3 Terman J.R.... Kolodkin A.L. (Cell 2002)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Junctional Rab13-binding protein (JRAB) regulates cell spreading via filamins. (PubMed id 23890175)2 Sakane A.... Sasaki T. (Genes Cells 2013)
    6. Proteomic profiling of Myc-associated proteins. (PubMed id 21150319)1 Agrawal P....Sedivy J.M. (Cell Cycle 2010)
    7. Systematic analysis of human protein complexes identifies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R.... Peters J.M. (Science 2010)
    8. Involvement of Rab13 and JRAB/MICAL-L2 in epithelial cell scattering. (PubMed id 17891173)1 Kanda I....Sasaki T. (Oncogene 2008)
    9. Phosphoproteome of resting human platelets. (PubMed id 18088087)2 Zahedi R.P.... Sickmann A. (J. Proteome Res. 2008)
    10. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 79778 HGNC: 29672 AceView: MICAL-L2 Ensembl:ENSG00000164877 euGenes: HUgn79778
    ECgene: MICALL2 H-InvDB: MICALL2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for MICALL2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MICALL2 gene:
    Search GeneIP for patents involving MICALL2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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