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Aliases for MICALL1 Gene

Aliases for MICALL1 Gene

  • MICAL Like 1 2 3 5
  • Molecule Interacting With Rab13 2 3 4
  • MIRAB13 3 4
  • MICAL-Like Protein 1 3
  • MICAL-Like 1 2
  • MICAL-L1 3
  • KIAA1668 4

External Ids for MICALL1 Gene

Previous GeneCards Identifiers for MICALL1 Gene

  • GC22P036632
  • GC22P038301
  • GC22P021269

Summaries for MICALL1 Gene

GeneCards Summary for MICALL1 Gene

MICALL1 (MICAL Like 1) is a Protein Coding gene. GO annotations related to this gene include identical protein binding and phosphatidic acid binding. An important paralog of this gene is MICALL2.

UniProtKB/Swiss-Prot for MICALL1 Gene

  • Probable lipid-binding protein with higher affinity for phosphatidic acid, a lipid enriched in recycling endosome membranes. On endosome membranes, may act as a downstream effector of Rab proteins recruiting cytosolic proteins to regulate membrane tubulation. May be involved in a late step of receptor-mediated endocytosis regulating for instance endocytosed-EGF receptor trafficking. Alternatively, may regulate slow endocytic recycling of endocytosed proteins back to the plasma membrane. May indirectly play a role in neurite outgrowth.

Gene Wiki entry for MICALL1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MICALL1 Gene

Genomics for MICALL1 Gene

Regulatory Elements for MICALL1 Gene

Enhancers for MICALL1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22F037931 1.2 FANTOM5 Ensembl ENCODE 11.9 +27.5 27466 2.9 HDGF MLX ZFP64 ARID4B SIN3A FEZF1 ZNF48 ZNF2 GLIS2 ZNF207 GALR3 EIF3L ENSG00000230149 ENSG00000273076 ENSG00000272669 ENSG00000225450 RNU6-900P MICALL1 SOX10 PRDX3P1
GH22F037891 1.1 FANTOM5 Ensembl ENCODE 7.8 -9.9 -9863 8.9 HDGF PKNOX1 MLX ZFP64 ARID4B DMAP1 ZNF48 SLC30A9 GLIS2 ELK1 GALR3 PICK1 MICALL1 CARD10 EIF3L TRIOBP H1F0 PLA2G6 SH3BP1 CDC42EP1
GH22F038217 1.4 FANTOM5 Ensembl ENCODE 1.6 +313.8 313815 3.8 ZFP64 ARID4B DMAP1 ZNF2 ZNF48 FOS ZNF263 SP5 JUNB SMARCB1 TMEM184B BAIAP2L2 MAFF CSNK1E MICALL1 GC22P038220 PLA2G6
GH22F037543 1.5 FANTOM5 Ensembl ENCODE 1.5 -358.5 -358502 6.5 HDGF MLX ARID4B FEZF1 DMAP1 YY1 ZNF143 SP3 SP5 ZHX2 LGALS2 C1QTNF6 KCTD17 CDC42EP1 LGALS1 CARD10 TRIOBP MICALL1 ANKRD54 POLR2F
GH22F037904 0.6 ENCODE 0.8 +0.9 931 4.8 ATF1 FEZF1 ZNF2 YY1 GLIS2 KLF7 FOS ZNF263 SP3 TSHZ1 GALR3 ENSG00000272669 ENSG00000230149 ENSG00000273076 PRDX3P1 ENSG00000225450 BAIAP2L2 MICALL1 ENSG00000278948
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MICALL1 on UCSC Golden Path with GeneCards custom track

Promoters for MICALL1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000618072 943 2001 ZNF2 GLIS2 KLF7 ZNF263 SP3 ZNF610 GLIS1 ZNF785 CTCF KLF1

Genomic Location for MICALL1 Gene

Chromosome:
22
Start:
37,905,657 bp from pter
End:
37,942,822 bp from pter
Size:
37,166 bases
Orientation:
Plus strand

Genomic View for MICALL1 Gene

Genes around MICALL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MICALL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MICALL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MICALL1 Gene

Proteins for MICALL1 Gene

  • Protein details for MICALL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N3F8-MILK1_HUMAN
    Recommended name:
    MICAL-like protein 1
    Protein Accession:
    Q8N3F8
    Secondary Accessions:
    • Q5TI16
    • Q7RTP5
    • Q8N3N8
    • Q9BVL9
    • Q9BY92
    • Q9UH43
    • Q9UH44
    • Q9UH45

    Protein attributes for MICALL1 Gene

    Size:
    863 amino acids
    Molecular mass:
    93441 Da
    Quaternary structure:
    • Homooligomer (Probable). Interacts (via NPF1 motif) with EHD1 (via EH domain); the interaction is direct and probably recruits EHD1 to membranes. Interacts with EHD3 (via EH domain). Interacts with RAB35 (GTP-bound form); the interaction is direct and probably recruits MICALL1 to membranes. Interacts with ACAP2; the interaction is indirect through RAB35. Interacts with RAB8A (GTP-bound form); regulates RAB8A association with recycling endosomes. Interacts with RAB13 (GTP-bound form). Interacts with ARF6 (GTP-bound form). Interacts with PACSIN2 (via the SH3 domain). Interacts with DPYSL2.
    SequenceCaution:
    • Sequence=CAD39036.1; Type=Frameshift; Positions=486, 507; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MICALL1 Gene

neXtProt entry for MICALL1 Gene

Post-translational modifications for MICALL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Abcam antibodies for MICALL1
  • Santa Cruz Biotechnology (SCBT) Antibodies for MICALL1

No data available for DME Specific Peptides for MICALL1 Gene

Domains & Families for MICALL1 Gene

Gene Families for MICALL1 Gene

Protein Domains for MICALL1 Gene

Suggested Antigen Peptide Sequences for MICALL1 Gene

Graphical View of Domain Structure for InterPro Entry

Q8N3F8

UniProtKB/Swiss-Prot:

MILK1_HUMAN :
  • Probably exists in a closed and an opened conformation due to interaction of the C-terminal RAB-binding domain (RBD) with the N-terminal CH (calponin-homology) domain. The conformational change is regulated by RAB13 and may modulate MICALL1 interactions with functional partners.
Domain:
  • Probably exists in a closed and an opened conformation due to interaction of the C-terminal RAB-binding domain (RBD) with the N-terminal CH (calponin-homology) domain. The conformational change is regulated by RAB13 and may modulate MICALL1 interactions with functional partners.
  • Contains 1 CH (calponin-homology) domain.
  • Contains 1 LIM zinc-binding domain.
genes like me logo Genes that share domains with MICALL1: view

Function for MICALL1 Gene

Molecular function for MICALL1 Gene

UniProtKB/Swiss-Prot Function:
Probable lipid-binding protein with higher affinity for phosphatidic acid, a lipid enriched in recycling endosome membranes. On endosome membranes, may act as a downstream effector of Rab proteins recruiting cytosolic proteins to regulate membrane tubulation. May be involved in a late step of receptor-mediated endocytosis regulating for instance endocytosed-EGF receptor trafficking. Alternatively, may regulate slow endocytic recycling of endocytosed proteins back to the plasma membrane. May indirectly play a role in neurite outgrowth.

Gene Ontology (GO) - Molecular Function for MICALL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19864458
GO:0008270 zinc ion binding IEA --
GO:0017137 Rab GTPase binding IEA,IPI 19864458
GO:0042802 identical protein binding IPI 23596323
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with MICALL1: view
genes like me logo Genes that share phenotypes with MICALL1: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MICALL1 Gene

Localization for MICALL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MICALL1 Gene

Recycling endosome membrane; Peripheral membrane protein. Late endosome membrane. Note=Localization to late endosomes is actin-dependent. Association to tubular recycling endosomes is regulated by RAB35 and ARF6.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MICALL1 Gene COMPARTMENTS Subcellular localization image for MICALL1 gene
Compartment Confidence
endosome 5
cytosol 3
nucleus 3
plasma membrane 1

Gene Ontology (GO) - Cellular Components for MICALL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome IEA --
GO:0005769 NOT early endosome IDA 21795389
GO:0005770 late endosome IDA 21795389
GO:0005802 NOT trans-Golgi network IDA 21795389
GO:0005913 cell-cell adherens junction IDA 25468996
genes like me logo Genes that share ontologies with MICALL1: view

Pathways & Interactions for MICALL1 Gene

SuperPathways for MICALL1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MICALL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006612 protein targeting to membrane IMP 19864458
GO:0006810 transport IEA --
GO:0006897 endocytosis IMP 20801876
GO:0006898 receptor-mediated endocytosis IMP 21795389
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with MICALL1: view

No data available for Pathways by source and SIGNOR curated interactions for MICALL1 Gene

Transcripts for MICALL1 Gene

Unigene Clusters for MICALL1 Gene

MICAL-like 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MICALL1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^
SP1:
SP2: - - -
SP3: -
SP4: - - - - -
SP5:
SP6:
SP7:
SP8:
SP9:

ExUns: 20
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for MICALL1 Gene

GeneLoc Exon Structure for
MICALL1
ECgene alternative splicing isoforms for
MICALL1

Expression for MICALL1 Gene

mRNA expression in normal human tissues for MICALL1 Gene

Protein differential expression in normal tissues from HIPED for MICALL1 Gene

This gene is overexpressed in Neutrophil (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MICALL1 Gene



NURSA nuclear receptor signaling pathways regulating expression of MICALL1 Gene:

MICALL1

SOURCE GeneReport for Unigene cluster for MICALL1 Gene:

Hs.517610
genes like me logo Genes that share expression patterns with MICALL1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MICALL1 Gene

Orthologs for MICALL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for MICALL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MICALL1 34 35
  • 99.35 (n)
cow
(Bos Taurus)
Mammalia MICALL1 34 35
  • 85.88 (n)
dog
(Canis familiaris)
Mammalia MICALL1 34 35
  • 85.4 (n)
mouse
(Mus musculus)
Mammalia Micall1 34 16 35
  • 80.81 (n)
rat
(Rattus norvegicus)
Mammalia Micall1 34
  • 80.09 (n)
oppossum
(Monodelphis domestica)
Mammalia MICALL1 35
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MICALL1 35
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves MICALL1 34 35
  • 69.07 (n)
lizard
(Anolis carolinensis)
Reptilia MICALL1 35
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia micall1 34
  • 58.93 (n)
Str.16017 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.30156 34
zebrafish
(Danio rerio)
Actinopterygii micall1 34 35
  • 53.91 (n)
MICALL1 (1 of 3) 35
  • 39 (a)
OneToMany
MICALL1 (3 of 3) 35
  • 35 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea T15B12.1 35
  • 13 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 32 (a)
OneToOne
Species where no ortholog for MICALL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MICALL1 Gene

ENSEMBL:
Gene Tree for MICALL1 (if available)
TreeFam:
Gene Tree for MICALL1 (if available)

Paralogs for MICALL1 Gene

(6) SIMAP similar genes for MICALL1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with MICALL1: view

Variants for MICALL1 Gene

Sequence variations from dbSNP and Humsavar for MICALL1 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
VAR_036192 A breast cancer sample
rs1003689 -- 37,912,284(-) GGGGC(A/G)ACCCC intron-variant
rs10212043 -- 37,911,073(+) GCGGC(C/T)TGGAG intron-variant
rs111399606 -- 37,920,687(+) GAGGC(C/G)GAGGC intron-variant
rs111432925 -- 37,936,674(+) GATCA(C/G/T)GAGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MICALL1 Gene

Variant ID Type Subtype PubMed ID
esv3575479 CNV gain 25503493
esv3893482 CNV gain 25118596
nsv1144971 CNV deletion 24896259

Variation tolerance for MICALL1 Gene

Residual Variation Intolerance Score: 32.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.29; 95.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MICALL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MICALL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MICALL1 Gene

Disorders for MICALL1 Gene

Relevant External Links for MICALL1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MICALL1

No disorders were found for MICALL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MICALL1 Gene

Publications for MICALL1 Gene

  1. MICALs, a family of conserved flavoprotein oxidoreductases, function in plexin-mediated axonal repulsion. (PMID: 12110185) Terman J.R. … Kolodkin A.L. (Cell 2002) 2 3 4 64
  2. Identification of novel transcribed sequences on human chromosome 22 by expressed sequence tag mapping. (PMID: 11258795) Hirosawa M. … Ohara O. (DNA Res. 2001) 2 3 4 64
  3. Cooperation of MICAL-L1, syndapin2, and phosphatidic acid in tubular recycling endosome biogenesis. (PMID: 23596323) Giridharan S.S. … Caplan S. (Mol. Biol. Cell 2013) 3 4 64
  4. MICAL-L1 is a tubular endosomal membrane hub that connects Rab35 and Arf6 with Rab8a. (PMID: 21951725) Rahajeng J. … Caplan S. (Traffic 2012) 3 4 64
  5. MICAL-like1 mediates epidermal growth factor receptor endocytosis. (PMID: 21795389) Abou-Zeid N. … Zahraoui A. (Mol. Biol. Cell 2011) 3 4 64

Products for MICALL1 Gene

Sources for MICALL1 Gene

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