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MICALL1 Gene

protein-coding   GIFtS: 51
GCID: GC22P038301

MICAL-Like 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
MICAL-Like 11 2     MICAL-Like Protein 12
Molecule Interacting With Rab131 2 3     KIAA16683
MIRAB132 3     MIRab133
MICAL-L12     

External Ids:    HGNC: 298041   Entrez Gene: 853772   Ensembl: ENSG000001001397   UniProtKB: Q8N3F83   

Export aliases for MICALL1 gene to outside databases

Previous GC identifers: GC22P036632 GC22P021269


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MICALL1 Gene:
MICALL1 (MICAL-like 1) is a protein-coding gene. GO annotations related to this gene include Rab GTPase binding. An important paralog of this gene is MICALL2.

UniProtKB/Swiss-Prot: MILK1_HUMAN, Q8N3F8
Function: Probable lipid-binding protein with higher affinity for phosphatidic acid, a lipid enriched in recycling
endosome membranes. On endosome membranes, may act as a downstream effector of Rab proteins recruiting cytosolic
proteins to regulate membrane tubulation. May be involved in a late step of receptor-mediated endocytosis
regulating for instance endocytosed-EGF receptor trafficking. Alternatively, may regulate slow endocytic
recycling of endocytosed proteins back to the plasma membrane. May indirectly play a role in neurite outgrowth

Gene Wiki entry for MICALL1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000022.10  NT_011520.13  NC_018933.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MICALL1 gene promoter:
         POU2F2 (Oct-2.1)   Oct-B1   oct-B3   oct-B2   POU2F2   POU2F2C   POU2F1   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMICALL1 promoter sequence
   Search Chromatin IP Primers for MICALL1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MICALL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.1   Ensembl cytogenetic band:  22q13.1   HGNC cytogenetic band: 22q13.1

MICALL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MICALL1 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P038301:  view genomic region     (about GC identifiers)

Start:
38,301,664 bp from pter      End:
38,338,829 bp from pter
Size:
37,166 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: MILK1_HUMAN, Q8N3F8 (See protein sequence)
Recommended Name: MICAL-like protein 1  
Size: 863 amino acids; 93441 Da
Subunit: Homooligomer (Probable). Interacts (via NPF1 motif) with EHD1 (via EH domain); the interaction is direct
and probably recruits EHD1 to membranes. Interacts with EHD3 (via EH domain). Interacts with RAB35 (GTP-bound
form); the interaction is direct and probably recruits MICALL1 to membranes. Interacts with ACAP2; the
interaction is indirect through RAB35. Interacts with RAB8A (GTP-bound form); regulates RAB8A association with
recycling endosomes. Interacts with RAB13 (GTP-bound form). Interacts with ARF6 (GTP-bound form). Interacts with
PACSIN2 (via the SH3 domain). Interacts with DPYSL2
Sequence caution: Sequence=CAD39036.1; Type=Frameshift; Positions=486, 507;
1 PDB 3D structure from and Proteopedia for MICALL1:
2KSP (3D)    
Secondary accessions: Q5TI16 Q7RTP5 Q8N3N8 Q9BVL9 Q9BY92 Q9UH43 Q9UH44 Q9UH45

Explore the universe of human proteins at neXtProt for MICALL1: NX_Q8N3F8

Explore proteomics data for MICALL1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MICALL1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_203744.1  
    ENSEMBL proteins: 
     ENSP00000404543   ENSP00000215957   ENSP00000406053   ENSP00000416766  

    MICALL1 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for MICALL1

     
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    antibodies-online peptides for MICALL1

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    antibodies-online antibodies for MICALL1 (14 products) 

    MICALL1 Assay Products:

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    antibodies-online kits for MICALL1 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR022735 DUF3585
     IPR028563 MICAL-L1
     IPR001715 CH-domain
     IPR001781 Znf_LIM

    Graphical View of Domain Structure for InterPro Entry Q8N3F8

    ProtoNet protein and cluster: Q8N3F8

    2 Blocks protein domains:
    IPB001715 Calponin-like actin-binding
    IPB001781 Zn-binding protein


    UniProtKB/Swiss-Prot: MILK1_HUMAN, Q8N3F8
    Domain: Probably exists in a closed and an opened conformation due to interaction of the C-terminal RAB-binding
    domain (RBD) with the N-terminal CH (calponin-homology) domain. The conformational change is regulated by RAB13
    and may modulate MICALL1 interactions with functional partners
    Similarity: Contains 1 CH (calponin-homology) domain
    Similarity: Contains 1 LIM zinc-binding domain


    Find genes that share domains with MICALL1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MILK1_HUMAN, Q8N3F8
    Function: Probable lipid-binding protein with higher affinity for phosphatidic acid, a lipid enriched in recycling
    endosome membranes. On endosome membranes, may act as a downstream effector of Rab proteins recruiting cytosolic
    proteins to regulate membrane tubulation. May be involved in a late step of receptor-mediated endocytosis
    regulating for instance endocytosed-EGF receptor trafficking. Alternatively, may regulate slow endocytic
    recycling of endocytosed proteins back to the plasma membrane. May indirectly play a role in neurite outgrowth

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI19864458
    GO:0008270zinc ion binding IEA--
    GO:0017137Rab GTPase binding IPI19864458
    GO:0042802identical protein binding IPI--
    GO:0070300phosphatidic acid binding IDA--
         
    Find genes that share ontologies with MICALL1           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MICALL1
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MICALL1

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    miRTarBase miRNAs that target MICALL1:
    hsa-mir-423-5p (MIRT038075), hsa-mir-423-3p (MIRT042642), hsa-mir-7-5p (MIRT025812), hsa-mir-93-5p (MIRT048743), hsa-mir-1301-3p (MIRT035961)

    Block miRNA regulation of human, mouse, rat MICALL1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MICALL1 (see all 17):
    hsa-miR-520f hsa-miR-328 hsa-miR-125a-5p hsa-miR-3167 hsa-miR-374c hsa-miR-9 hsa-miR-3150b-3p hsa-miR-125b
    SwitchGear 3'UTR luciferase reporter plasmidMICALL1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat MICALL1

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    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MICALL1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MICALL1

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MILK1_HUMAN, Q8N3F8: Recycling endosome membrane; Peripheral membrane protein. Late endosome membrane.
    Note=Localization to late endosomes is actin-dependent. Association to tubular recycling endosomes is regulated
    by RAB35 and ARF6
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus3
    cytoskeleton2
    endosome1
    lysosome1
    vacuole1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005769NOT early endosome IDA--
    GO:0005770late endosome IDA--
    GO:0005802NOT trans-Golgi network IDA--
    GO:0019898extrinsic component of membrane IDA19864458
    GO:0031902late endosome membrane IEA--

    Find genes that share ontologies with MICALL1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MICALL1
    Interactions:

        Search GeneGlobe Interaction Network for MICALL1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 24)

    Selected Interacting proteins for MICALL1 (Q8N3F81, 2, 3 ENSP000002159574) via UniProtKB, MINT, STRING, and/or I2D (see all 26)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHABP319462, 3, ENSP000003001614MINT-50981 I2D: score=4 STRING: ENSP00000300161
    YWHAGP619812, 3, ENSP000003063304MINT-50881 I2D: score=4 STRING: ENSP00000306330
    PACSIN3Q9UKS63, ENSP000002988384I2D: score=1 STRING: ENSP00000298838
    RAB1AP628203, ENSP000003872864I2D: score=1 STRING: ENSP00000387286
    PACSIN1Q9BY113, ENSP000002444584I2D: score=1 STRING: ENSP00000244458
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006612protein targeting to membrane IMP19864458
    GO:0006897endocytosis IMP--
    GO:0006898receptor-mediated endocytosis IMP--
    GO:0031175neuron projection development ISS--
    GO:0032458slow endocytic recycling IMP19864458

    Find genes that share ontologies with MICALL1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MICALL1 (MILK1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MICALL1 gene: 
    NM_033386.3  

    Unigene Cluster for MICALL1:

    MICAL-like 1
    Hs.517610  [show with all ESTs]
    Unigene Representative Sequence: AB051455
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000445494 ENST00000215957(uc003aui.3) ENST00000489812 ENST00000454685
    ENST00000402631 ENST00000424008
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate MICALL1 (see all 17):
    hsa-miR-520f hsa-miR-328 hsa-miR-125a-5p hsa-miR-3167 hsa-miR-374c hsa-miR-9 hsa-miR-3150b-3p hsa-miR-125b
    SwitchGear 3'UTR luciferase reporter plasmidMICALL1 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat MICALL1

    Additional mRNA sequence: 

    AB051455.1 AJ496196.1 AK056603.1 AK127819.1 AL833860.1 AL834373.1 BC001090.2 BC082243.1 
    CR456437.1 CR749566.1 

    9 DOTS entries:

    DT.91987893  DT.445384  DT.40119502  DT.95275035  DT.100000098  DT.100791892  DT.120675737  DT.95275044 
    DT.121618611 

    Selected AceView cDNA sequences (see all 180):

    BE047773 CB120485 BQ641566 CR601225 AI283282 CB322062 H55178 AW955290 
    AI057103 BG319575 CA306483 BQ001723 BM702932 BC001090 AK127819 AA299470 
    BC082243 CB123897 BM470302 BU607291 CR456437 NM_033386 BE857505 AA303087 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MICALL1 (see all 9)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^
    SP1:                                                                                                                                                            
    SP2:        -     -     -                                                                                                                                       
    SP3:                    -                                                                                                                                       
    SP4:                    -           -                 -     -     -                                                                                             
    SP5:                                                                                                                                                            

    ExUns: 20
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for MICALL1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MICALL1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTCATCACTG
    MICALL1 Expression
    About this image

    MICALL1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MICALL1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.517610
        Custom PCR Arrays for MICALL1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MICALL1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MICALL1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Micall11 , 5 microtubule associated monoxygenase, calponin and LIM more5
    microtubule associated monooxygenase, calponin and more1
    80.81(n)1
    79.32(a)1
      15 (37.70 cM)5
    270081  NM_177461.11  NP_803412.11 
     791089835 
    chicken
    (Gallus gallus)
    Aves MICALL11 MICAL-like 1 69.07(n)
    66.19(a)
      418032  NM_001201448.1  NP_001188377.1 
    lizard
    (Anolis carolinensis)
    Reptilia MICALL16
    MICAL-like 1
    57(a)
    1 ↔ 1
    GL343460.1(59847-97079)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.301562 Xenopus laevis transcribed sequence with weak similarity more 77.43(n)    48022287 
    zebrafish
    (Danio rerio)
    Actinopterygii micall11 MICAL-like 1 53.91(n)
    51.64(a)
      100149741  XM_001922140.3  XP_001922175.2 
    worm
    (Caenorhabditis elegans)
    Secernentea T15B12.16
    Protein T15B12.1, isoform b
    13(a)
    1 → many
    III(5288180-5298352) WBGene00020530


    ENSEMBL Gene Tree for MICALL1 (if available)
    TreeFam Gene Tree for MICALL1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MICALL1 gene
    MICALL22  MICAL22  EHBP12  MICAL32  SPECC12  SMTNL22  MICALCL2  MICAL12  
    SPECC1L-ADORA2A2  SMTN2  EHBP1L12  SPECC1L2  SMTNL12  
    6 SIMAP similar genes for MICALL1 using alignment to 4 protein entries:     MILK1_HUMAN (see all proteins):
    DKFZp686M2226    MICAL-L1    MICAL3    MICALCL    EHBP1    MICALL2

    Find genes that share paralogs with MICALL1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MICALL1 (see all 813)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0361924
    A breast cancer sample4--see VAR_0361922 E K mis40--------
    rs1445875321,2
    --38300304(+) GATCCA/GCCCAC 1 -- us2k10--------
    rs1911023781,2
    --38300447(+) GCCTCA/GGCCTC 1 -- us2k10--------
    rs43464871,2
    C,F,A--38300474(+) ACAGGT/CATGAG 1 -- us2k18Minor allele frequency- C:0.20NA WA CSA EA 133
    rs1818401721,2
    C--38300497(+) ACCCCA/C/GCCCCC 1 -- us2k10--------
    rs2016634661,2
    C--38300497(+) ACCCC-/GCCCCC 1 -- us2k10--------
    rs1863593861,2
    --38300556(+) TGCTGA/GTGTCA 1 -- us2k10--------
    rs1484754231,2
    C--38300563(+) GTCAGG/TATCCT 1 -- us2k10--------
    rs121663101,2
    H--38300642(+) GGACAG/CGGCAG 1 -- us2k1 tfbs34Minor allele frequency- C:0.00NS EA 420
    rs57505071,2
    C,F,H--38300785(+) AGCCCA/TGATTG 1 -- us2k19Minor allele frequency- T:0.11NS EA NA 1048

    HapMap Linkage Disequilibrium report for MICALL1 (38301664 - 38338829 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for MICALL1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv915035CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MICALL1
    DNA2.0 Custom Variant and Variant Library Synthesis for MICALL1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MICALL1 gene, integrated from 10 sources (see all 31):
    (articles sorted by number of sources associating them with MICALL1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. MICALs, a family of conserved flavoprotein oxidoreductases, function in plexin-mediated axonal repulsion. (PubMed id 12110185)1, 2, 3 Terman J.R.... Kolodkin A.L. (Cell 2002)
    2. Identification of novel transcribed sequences on human chromosome 22 by expressed sequence tag mapping. (PubMed id 11258795)1, 2, 3 Hirosawa M.... Ohara O. (DNA Res. 2001)
    3. Cooperation of MICAL-L1, syndapin2, and phosphatidic acid in tubular recycling endosome biogenesis. (PubMed id 23596323)1, 2 Giridharan S.S.... Caplan S. (Mol. Biol. Cell 2013)
    4. MICAL-L1 is a tubular endosomal membrane hub that connects Rab35 and Arf6 with Rab8a. (PubMed id 21951725)1, 2 Rahajeng J....Caplan S. (Traffic 2012)
    5. MICAL-like1 mediates epidermal growth factor receptor endocytosis. (PubMed id 21795389)1, 2 Abou-Zeid N....Zahraoui A. (Mol. Biol. Cell 2011)
    6. MICAL-L1 links EHD1 to tubular recycling endosomes and regulates receptor recycling. (PubMed id 19864458)1, 2 Sharma M....Caplan S. (Mol. Biol. Cell 2009)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (Genome Biol. 2004)
    9. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I.... Wright H. (Nature 1999)
    10. The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition. (PubMed id 24163370)1 Lu L....Zhang L. (J. Biol. Chem. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 85377 HGNC: 29804 AceView: MICAL-L1 Ensembl:ENSG00000100139 euGenes: HUgn85377
    ECgene: MICALL1 H-InvDB: MICALL1

    (According to HUGE)
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    HUGE: KIAA1668

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for MICALL1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for MICALL1 gene:
    Search GeneIP for patents involving MICALL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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