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Aliases for MICALL1 Gene

Aliases for MICALL1 Gene

  • MICAL-Like 1 2 3
  • Molecule Interacting With Rab13 2 3 4
  • MIRAB13 3 4
  • MICAL-Like Protein 1 3
  • MICAL-L1 3
  • KIAA1668 4

External Ids for MICALL1 Gene

Summaries for MICALL1 Gene

GeneCards Summary for MICALL1 Gene

MICALL1 (MICAL-Like 1) is a Protein Coding gene. GO annotations related to this gene include Rab GTPase binding. An important paralog of this gene is SMTNL2.

UniProtKB/Swiss-Prot for MICALL1 Gene

  • Probable lipid-binding protein with higher affinity for phosphatidic acid, a lipid enriched in recycling endosome membranes. On endosome membranes, may act as a downstream effector of Rab proteins recruiting cytosolic proteins to regulate membrane tubulation. May be involved in a late step of receptor-mediated endocytosis regulating for instance endocytosed-EGF receptor trafficking. Alternatively, may regulate slow endocytic recycling of endocytosed proteins back to the plasma membrane. May indirectly play a role in neurite outgrowth.

Gene Wiki entry for MICALL1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MICALL1 Gene

Genomics for MICALL1 Gene

Genomic Location for MICALL1 Gene

Start:
37,905,657 bp from pter
End:
37,942,822 bp from pter
Size:
37,166 bases
Orientation:
Plus strand

Genomic View for MICALL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MICALL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MICALL1 Gene

Regulatory Elements for MICALL1 Gene

Proteins for MICALL1 Gene

  • Protein details for MICALL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N3F8-MILK1_HUMAN
    Recommended name:
    MICAL-like protein 1
    Protein Accession:
    Q8N3F8
    Secondary Accessions:
    • Q5TI16
    • Q7RTP5
    • Q8N3N8
    • Q9BVL9
    • Q9BY92
    • Q9UH43
    • Q9UH44
    • Q9UH45

    Protein attributes for MICALL1 Gene

    Size:
    863 amino acids
    Molecular mass:
    93441 Da
    Quaternary structure:
    • Homooligomer (Probable). Interacts (via NPF1 motif) with EHD1 (via EH domain); the interaction is direct and probably recruits EHD1 to membranes. Interacts with EHD3 (via EH domain). Interacts with RAB35 (GTP-bound form); the interaction is direct and probably recruits MICALL1 to membranes. Interacts with ACAP2; the interaction is indirect through RAB35. Interacts with RAB8A (GTP-bound form); regulates RAB8A association with recycling endosomes. Interacts with RAB13 (GTP-bound form). Interacts with ARF6 (GTP-bound form). Interacts with PACSIN2 (via the SH3 domain). Interacts with DPYSL2.
    SequenceCaution:
    • Sequence=CAD39036.1; Type=Frameshift; Positions=486, 507; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MICALL1 Gene

neXtProt entry for MICALL1 Gene

Proteomics data for MICALL1 Gene at MOPED

Post-translational modifications for MICALL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MICALL1 Gene

No data available for DME Specific Peptides for MICALL1 Gene

Domains for MICALL1 Gene

Protein Domains for MICALL1 Gene

UniProtKB/Swiss-Prot:

MILK1_HUMAN
Domain:
  • Probably exists in a closed and an opened conformation due to interaction of the C-terminal RAB-binding domain (RBD) with the N-terminal CH (calponin-homology) domain. The conformational change is regulated by RAB13 and may modulate MICALL1 interactions with functional partners.:
    • Q8N3F8
  • Contains 1 CH (calponin-homology) domain.:
    • Q8N3F8
  • Contains 1 LIM zinc-binding domain.:
    • Q8N3F8
genes like me logo Genes that share domains with MICALL1: view

No data available for Gene Families for MICALL1 Gene

Function for MICALL1 Gene

Molecular function for MICALL1 Gene

UniProtKB/Swiss-Prot Function: Probable lipid-binding protein with higher affinity for phosphatidic acid, a lipid enriched in recycling endosome membranes. On endosome membranes, may act as a downstream effector of Rab proteins recruiting cytosolic proteins to regulate membrane tubulation. May be involved in a late step of receptor-mediated endocytosis regulating for instance endocytosed-EGF receptor trafficking. Alternatively, may regulate slow endocytic recycling of endocytosed proteins back to the plasma membrane. May indirectly play a role in neurite outgrowth.

Gene Ontology (GO) - Molecular Function for MICALL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19864458
GO:0008270 zinc ion binding IEA --
GO:0017137 Rab GTPase binding IPI 19864458
GO:0042802 identical protein binding IPI 23596323
GO:0070300 phosphatidic acid binding IDA 23596323
genes like me logo Genes that share ontologies with MICALL1: view

miRNA for MICALL1 Gene

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for MICALL1 Gene

Localization for MICALL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MICALL1 Gene

Recycling endosome membrane; Peripheral membrane protein. Late endosome membrane. Note=Localization to late endosomes is actin-dependent. Association to tubular recycling endosomes is regulated by RAB35 and ARF6.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MICALL1 Gene COMPARTMENTS Subcellular localization image for MICALL1 gene
Compartment Confidence
cytosol 3
nucleus 3
cytoskeleton 2
endosome 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for MICALL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005769 NOT early endosome IDA 21795389
GO:0005770 late endosome IDA 21795389
GO:0005802 NOT trans-Golgi network IDA 21795389
GO:0010008 endosome membrane --
GO:0019898 extrinsic component of membrane IDA 19864458
genes like me logo Genes that share ontologies with MICALL1: view

Pathways for MICALL1 Gene

SuperPathways for MICALL1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MICALL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006612 protein targeting to membrane IMP 19864458
GO:0006897 endocytosis IMP 20801876
GO:0006898 receptor-mediated endocytosis IMP 21795389
GO:0031175 neuron projection development ISS --
GO:0032456 endocytic recycling --
genes like me logo Genes that share ontologies with MICALL1: view

No data available for Pathways by source for MICALL1 Gene

Transcripts for MICALL1 Gene

Unigene Clusters for MICALL1 Gene

MICAL-like 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MICALL1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^
SP1:
SP2: - - -
SP3: -
SP4: - - - - -
SP5:
SP6:
SP7:
SP8:
SP9:

ExUns: 20
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for MICALL1 Gene

GeneLoc Exon Structure for
MICALL1
ECgene alternative splicing isoforms for
MICALL1

Expression for MICALL1 Gene

mRNA expression in normal human tissues for MICALL1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MICALL1 Gene

SOURCE GeneReport for Unigene cluster for MICALL1 Gene Hs.517610

genes like me logo Genes that share expressions with MICALL1: view

Orthologs for MICALL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for MICALL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MICALL1 36
  • 99.35 (n)
  • 99.02 (a)
MICALL1 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MICALL1 36
  • 85.88 (n)
  • 85.45 (a)
MICALL1 37
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MICALL1 36
  • 85.4 (n)
  • 85.63 (a)
MICALL1 37
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Micall1 36
  • 80.81 (n)
  • 79.32 (a)
Micall1 16
Micall1 37
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MICALL1 37
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MICALL1 37
  • 61 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Micall1 36
  • 80.09 (n)
  • 78.21 (a)
chicken
(Gallus gallus)
Aves MICALL1 36
  • 69.07 (n)
  • 66.19 (a)
MICALL1 37
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MICALL1 37
  • 57 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.30156 36
tropical clawed frog
(Silurana tropicalis)
Amphibia micall1 36
  • 58.93 (n)
  • 59.63 (a)
Str.16017 36
zebrafish
(Danio rerio)
Actinopterygii micall1 36
  • 53.91 (n)
  • 51.64 (a)
micall1 37
  • 44 (a)
OneToMany
MICALL1 (1 of 3) 37
  • 39 (a)
OneToMany
MICALL1 (3 of 3) 37
  • 35 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea T15B12.1 37
  • 13 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 32 (a)
OneToOne
Species with no ortholog for MICALL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MICALL1 Gene

ENSEMBL:
Gene Tree for MICALL1 (if available)
TreeFam:
Gene Tree for MICALL1 (if available)

Paralogs for MICALL1 Gene

Selected SIMAP similar genes for MICALL1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with MICALL1: view

Variants for MICALL1 Gene

Sequence variations from dbSNP and Humsavar for MICALL1 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs713891 -- 37,916,720(+) GGGCA(G/T)GAGTG intron-variant
rs713922 -- 37,911,561(+) GCACT(A/G)CGCCC intron-variant
rs1003689 -- 37,912,284(-) GGGGC(A/C/G)ACCCC intron-variant
rs2072859 -- 37,926,343(+) CCTGT(C/T)GTGCT intron-variant
rs2272829 - 37,927,693(+) TGCCC(C/T)CAGGA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for MICALL1 Gene

Variant ID Type Subtype PubMed ID
nsv915035 CNV Loss 21882294

Relevant External Links for MICALL1 Gene

HapMap Linkage Disequilibrium report
MICALL1

Disorders for MICALL1 Gene

No disorders were found for MICALL1 Gene.

No data available for UniProtKB/Swiss-Prot for MICALL1 Gene

Publications for MICALL1 Gene

  1. MICALs, a family of conserved flavoprotein oxidoreductases, function in plexin-mediated axonal repulsion. (PMID: 12110185) Terman J.R. … Kolodkin A.L. (Cell 2002) 2 3 4
  2. Identification of novel transcribed sequences on human chromosome 22 by expressed sequence tag mapping. (PMID: 11258795) Hirosawa M. … Ohara O. (DNA Res. 2001) 2 3 4
  3. MICAL-L1 links EHD1 to tubular recycling endosomes and regulates receptor recycling. (PMID: 19864458) Sharma M. … Caplan S. (Mol. Biol. Cell 2009) 3 4
  4. MICAL-like1 mediates epidermal growth factor receptor endocytosis. (PMID: 21795389) Abou-Zeid N. … Zahraoui A. (Mol. Biol. Cell 2011) 3 4
  5. MICAL-L1 is a tubular endosomal membrane hub that connects Rab35 and Arf6 with Rab8a. (PMID: 21951725) Rahajeng J. … Caplan S. (Traffic 2012) 3 4

Products for MICALL1 Gene

  • antibodies-online peptides for MICALL1
  • antibodies-online antibodies for MICALL1
  • antibodies-online kits for MICALL1

Sources for MICALL1 Gene

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