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Aliases for MICALL1 Gene

Aliases for MICALL1 Gene

  • MICAL Like 1 2 3 5
  • Molecule Interacting With Rab13 2 3 4
  • MICAL-Like 1 2 3
  • MIRAB13 3 4
  • MICAL-L1 3
  • KIAA1668 4

External Ids for MICALL1 Gene

Previous GeneCards Identifiers for MICALL1 Gene

  • GC22P036632
  • GC22P038301
  • GC22P021269

Summaries for MICALL1 Gene

GeneCards Summary for MICALL1 Gene

MICALL1 (MICAL Like 1) is a Protein Coding gene. GO annotations related to this gene include identical protein binding and phosphatidic acid binding. An important paralog of this gene is SMTNL2.

UniProtKB/Swiss-Prot for MICALL1 Gene

  • Probable lipid-binding protein with higher affinity for phosphatidic acid, a lipid enriched in recycling endosome membranes. On endosome membranes, may act as a downstream effector of Rab proteins recruiting cytosolic proteins to regulate membrane tubulation. May be involved in a late step of receptor-mediated endocytosis regulating for instance endocytosed-EGF receptor trafficking. Alternatively, may regulate slow endocytic recycling of endocytosed proteins back to the plasma membrane. May indirectly play a role in neurite outgrowth.

Gene Wiki entry for MICALL1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MICALL1 Gene

Genomics for MICALL1 Gene

Regulatory Elements for MICALL1 Gene

Enhancers for MICALL1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MICALL1 on UCSC Golden Path with GeneCards custom track

Promoters for MICALL1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MICALL1 on UCSC Golden Path with GeneCards custom track

Genomic Location for MICALL1 Gene

Chromosome:
22
Start:
37,905,657 bp from pter
End:
37,942,822 bp from pter
Size:
37,166 bases
Orientation:
Plus strand

Genomic View for MICALL1 Gene

Genes around MICALL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MICALL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MICALL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MICALL1 Gene

Proteins for MICALL1 Gene

  • Protein details for MICALL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N3F8-MILK1_HUMAN
    Recommended name:
    MICAL-like protein 1
    Protein Accession:
    Q8N3F8
    Secondary Accessions:
    • Q5TI16
    • Q7RTP5
    • Q8N3N8
    • Q9BVL9
    • Q9BY92
    • Q9UH43
    • Q9UH44
    • Q9UH45

    Protein attributes for MICALL1 Gene

    Size:
    863 amino acids
    Molecular mass:
    93441 Da
    Quaternary structure:
    • Homooligomer (Probable). Interacts (via NPF1 motif) with EHD1 (via EH domain); the interaction is direct and probably recruits EHD1 to membranes. Interacts with EHD3 (via EH domain). Interacts with RAB35 (GTP-bound form); the interaction is direct and probably recruits MICALL1 to membranes. Interacts with ACAP2; the interaction is indirect through RAB35. Interacts with RAB8A (GTP-bound form); regulates RAB8A association with recycling endosomes. Interacts with RAB13 (GTP-bound form). Interacts with ARF6 (GTP-bound form). Interacts with PACSIN2 (via the SH3 domain). Interacts with DPYSL2.
    SequenceCaution:
    • Sequence=CAD39036.1; Type=Frameshift; Positions=486, 507; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MICALL1 Gene

neXtProt entry for MICALL1 Gene

Proteomics data for MICALL1 Gene at MOPED

Post-translational modifications for MICALL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MICALL1 Gene

Antibody Products

No data available for DME Specific Peptides for MICALL1 Gene

Domains & Families for MICALL1 Gene

Gene Families for MICALL1 Gene

Protein Domains for MICALL1 Gene

Suggested Antigen Peptide Sequences for MICALL1 Gene

Graphical View of Domain Structure for InterPro Entry

Q8N3F8

UniProtKB/Swiss-Prot:

MILK1_HUMAN :
  • Probably exists in a closed and an opened conformation due to interaction of the C-terminal RAB-binding domain (RBD) with the N-terminal CH (calponin-homology) domain. The conformational change is regulated by RAB13 and may modulate MICALL1 interactions with functional partners.
Domain:
  • Probably exists in a closed and an opened conformation due to interaction of the C-terminal RAB-binding domain (RBD) with the N-terminal CH (calponin-homology) domain. The conformational change is regulated by RAB13 and may modulate MICALL1 interactions with functional partners.
  • Contains 1 CH (calponin-homology) domain.
  • Contains 1 LIM zinc-binding domain.
genes like me logo Genes that share domains with MICALL1: view

Function for MICALL1 Gene

Molecular function for MICALL1 Gene

UniProtKB/Swiss-Prot Function:
Probable lipid-binding protein with higher affinity for phosphatidic acid, a lipid enriched in recycling endosome membranes. On endosome membranes, may act as a downstream effector of Rab proteins recruiting cytosolic proteins to regulate membrane tubulation. May be involved in a late step of receptor-mediated endocytosis regulating for instance endocytosed-EGF receptor trafficking. Alternatively, may regulate slow endocytic recycling of endocytosed proteins back to the plasma membrane. May indirectly play a role in neurite outgrowth.
genes like me logo Genes that share phenotypes with MICALL1: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MICALL1 Gene

Localization for MICALL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MICALL1 Gene

Recycling endosome membrane; Peripheral membrane protein. Late endosome membrane. Note=Localization to late endosomes is actin-dependent. Association to tubular recycling endosomes is regulated by RAB35 and ARF6.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MICALL1 Gene COMPARTMENTS Subcellular localization image for MICALL1 gene
Compartment Confidence
endosome 5
cytosol 3
nucleus 3
plasma membrane 1

Gene Ontology (GO) - Cellular Components for MICALL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005802 NOT trans-Golgi network IDA 21795389
GO:0031902 late endosome membrane IEA --
genes like me logo Genes that share ontologies with MICALL1: view

Pathways & Interactions for MICALL1 Gene

SuperPathways for MICALL1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MICALL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006897 endocytosis IMP 20801876
GO:0032458 slow endocytic recycling IMP 19864458
GO:0036010 protein localization to endosome IEA,IMP 23596323
GO:1990090 cellular response to nerve growth factor stimulus IEA --
genes like me logo Genes that share ontologies with MICALL1: view

No data available for Pathways by source and SIGNOR curated interactions for MICALL1 Gene

Drugs & Compounds for MICALL1 Gene

No Compound Related Data Available

Transcripts for MICALL1 Gene

Unigene Clusters for MICALL1 Gene

MICAL-like 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MICALL1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^
SP1:
SP2: - - -
SP3: -
SP4: - - - - -
SP5:
SP6:
SP7:
SP8:
SP9:

ExUns: 20
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for MICALL1 Gene

GeneLoc Exon Structure for
MICALL1
ECgene alternative splicing isoforms for
MICALL1

Expression for MICALL1 Gene

mRNA expression in normal human tissues for MICALL1 Gene

Protein differential expression in normal tissues from HIPED for MICALL1 Gene

This gene is overexpressed in Neutrophil (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MICALL1 Gene



SOURCE GeneReport for Unigene cluster for MICALL1 Gene Hs.517610

genes like me logo Genes that share expression patterns with MICALL1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MICALL1 Gene

Orthologs for MICALL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for MICALL1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MICALL1 35
  • 85.88 (n)
  • 85.45 (a)
MICALL1 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MICALL1 35
  • 85.4 (n)
  • 85.63 (a)
MICALL1 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Micall1 35
  • 80.81 (n)
  • 79.32 (a)
Micall1 16
Micall1 36
  • 77 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MICALL1 35
  • 99.35 (n)
  • 99.02 (a)
MICALL1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Micall1 35
  • 80.09 (n)
  • 78.21 (a)
oppossum
(Monodelphis domestica)
Mammalia MICALL1 36
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MICALL1 36
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves MICALL1 35
  • 69.07 (n)
  • 66.19 (a)
MICALL1 36
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MICALL1 36
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia micall1 35
  • 58.93 (n)
  • 59.63 (a)
Str.16017 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.30156 35
zebrafish
(Danio rerio)
Actinopterygii micall1 35
  • 53.91 (n)
  • 51.64 (a)
micall1 36
  • 44 (a)
OneToMany
MICALL1 (1 of 3) 36
  • 39 (a)
OneToMany
MICALL1 (3 of 3) 36
  • 35 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea T15B12.1 36
  • 13 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 32 (a)
OneToOne
Species with no ortholog for MICALL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MICALL1 Gene

ENSEMBL:
Gene Tree for MICALL1 (if available)
TreeFam:
Gene Tree for MICALL1 (if available)

Paralogs for MICALL1 Gene

(6) SIMAP similar genes for MICALL1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with MICALL1: view

Variants for MICALL1 Gene

Sequence variations from dbSNP and Humsavar for MICALL1 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs9610875 - 37,927,500(+) AGAGC(A/G/T)CCAGC intron-variant, reference, missense
rs2272829 - 37,927,693(+) TGCCC(C/T)CAGGA intron-variant, reference, missense
VAR_036192 A breast cancer sample
rs34834842 - 37,932,590(+) CATCC(A/G)TGGAG nc-transcript-variant, reference, missense
rs2294359 -- 37,941,711(+) GCTCC(C/T)GCCCA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MICALL1 Gene

Variant ID Type Subtype PubMed ID
nsv915035 CNV Loss 21882294

Variation tolerance for MICALL1 Gene

Residual Variation Intolerance Score: 32.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.29; 95.32% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for MICALL1 Gene

Disorders for MICALL1 Gene

Relevant External Links for MICALL1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MICALL1

No disorders were found for MICALL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MICALL1 Gene

Publications for MICALL1 Gene

  1. MICALs, a family of conserved flavoprotein oxidoreductases, function in plexin-mediated axonal repulsion. (PMID: 12110185) Terman J.R. … Kolodkin A.L. (Cell 2002) 2 3 4 67
  2. Identification of novel transcribed sequences on human chromosome 22 by expressed sequence tag mapping. (PMID: 11258795) Hirosawa M. … Ohara O. (DNA Res. 2001) 2 3
  3. Novel functions for the endocytic regulatory proteins MICAL-L1 and EHD1 in mitosis. (PMID: 25287187) Reinecke J.B. … Caplan S. (Traffic 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. Regulation of Src trafficking and activation by the endocytic regulatory proteins MICAL-L1 and EHD1. (PMID: 24481818) Reinecke J.B. … Caplan S. (J. Cell. Sci. 2014) 3

Products for MICALL1 Gene

Sources for MICALL1 Gene

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