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Aliases for MICALCL Gene

Aliases for MICALCL Gene

  • MICAL C-Terminal Like 2 3
  • ERK2-Binding Testicular Protein 1 3 4
  • Ebitein-1 3 4
  • Ebitein1 3 6
  • MICAL C-Terminal-Like Protein 3

External Ids for MICALCL Gene

Previous GeneCards Identifiers for MICALCL Gene

  • GC11P012272
  • GC11P011984

Summaries for MICALCL Gene

GeneCards Summary for MICALCL Gene

MICALCL (MICAL C-Terminal Like) is a Protein Coding gene. GO annotations related to this gene include mitogen-activated protein kinase binding. An important paralog of this gene is SMTNL2.

UniProtKB/Swiss-Prot for MICALCL Gene

  • May cooperate with MAPK1/ERK2 via an intracellular signal transduction pathway in the morphogenetic development of round spermatids to spermatozoa.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MICALCL Gene

Genomics for MICALCL Gene

Regulatory Elements for MICALCL Gene

Genomic Location for MICALCL Gene

Start:
12,276,080 bp from pter
End:
12,362,140 bp from pter
Size:
86,061 bases
Orientation:
Plus strand

Genomic View for MICALCL Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MICALCL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MICALCL Gene

Proteins for MICALCL Gene

  • Protein details for MICALCL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZW33-MICLK_HUMAN
    Recommended name:
    MICAL C-terminal-like protein
    Protein Accession:
    Q6ZW33
    Secondary Accessions:
    • Q7RTP7
    • Q96JU6

    Protein attributes for MICALCL Gene

    Size:
    695 amino acids
    Molecular mass:
    77277 Da
    Quaternary structure:
    • Interacts with MAPK1/ERK2.
    SequenceCaution:
    • Sequence=BAB55422.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for MICALCL Gene

Proteomics data for MICALCL Gene at MOPED

Post-translational modifications for MICALCL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MICALCL Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MICALCL Gene

Domains for MICALCL Gene

Protein Domains for MICALCL Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MICALCL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6ZW33

UniProtKB/Swiss-Prot:

MICLK_HUMAN :
  • Q6ZW33
Family:
  • Belongs to the ebitein family.
genes like me logo Genes that share domains with MICALCL: view

No data available for Gene Families for MICALCL Gene

Function for MICALCL Gene

Molecular function for MICALCL Gene

UniProtKB/Swiss-Prot Function: May cooperate with MAPK1/ERK2 via an intracellular signal transduction pathway in the morphogenetic development of round spermatids to spermatozoa.

Gene Ontology (GO) - Molecular Function for MICALCL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051019 mitogen-activated protein kinase binding ISS --
genes like me logo Genes that share ontologies with MICALCL: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MICALCL Gene

Localization for MICALCL Gene

Subcellular locations from UniProtKB/Swiss-Prot for MICALCL Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MICALCL Gene COMPARTMENTS Subcellular localization image for MICALCL gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for MICALCL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm ISS --
genes like me logo Genes that share ontologies with MICALCL: view

Pathways for MICALCL Gene

SuperPathways for MICALCL Gene

No Data Available

Interacting Proteins for MICALCL Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000256186%0d%0a9606.ENSP00000310226%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000256186 Q6ZW33-MICLK_HUMAN for MICALCL Gene via STRING I2D

Gene Ontology (GO) - Biological Process for MICALCL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organismal development IEA --
GO:0007283 spermatogenesis IEA --
GO:0008150 biological_process ND --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with MICALCL: view

No data available for Pathways by source for MICALCL Gene

Transcripts for MICALCL Gene

mRNA/cDNA for MICALCL Gene

(14) Selected AceView cDNA sequences:
(2) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MICALCL Gene

MICAL C-terminal like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MICALCL Gene

No ASD Table

Relevant External Links for MICALCL Gene

GeneLoc Exon Structure for
MICALCL
ECgene alternative splicing isoforms for
MICALCL

Expression for MICALCL Gene

mRNA expression in normal human tissues for MICALCL Gene

mRNA differential expression in normal tissues according to GTEx for MICALCL Gene

This gene is overexpressed in Testis (12.3), Skin - Sun Exposed (Lower leg) (8.0), and Skin - Not Sun Exposed (Suprapubic) (7.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for MICALCL Gene

SOURCE GeneReport for Unigene cluster for MICALCL Gene Hs.128196

genes like me logo Genes that share expressions with MICALCL: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for MICALCL Gene

Orthologs for MICALCL Gene

This gene was present in the common ancestor of animals.

Orthologs for MICALCL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MICALCL 35
  • 98.94 (n)
  • 97.53 (a)
MICALCL 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MICALCL 35
  • 80.88 (n)
  • 70.71 (a)
MICALCL 36
  • 67 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Micalcl 35
  • 74.26 (n)
  • 65.59 (a)
Micalcl 16
Micalcl 36
  • 62 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MICALCL 36
  • 44 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Micalcl 35
  • 74.52 (n)
  • 65.29 (a)
fruit fly
(Drosophila melanogaster)
Insecta MICAL-like 36
  • 14 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1030 36
  • 23 (a)
OneToOne
Species with no ortholog for MICALCL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MICALCL Gene

ENSEMBL:
Gene Tree for MICALCL (if available)
TreeFam:
Gene Tree for MICALCL (if available)

Paralogs for MICALCL Gene

Selected SIMAP similar genes for MICALCL Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MICALCL: view

Variants for MICALCL Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for MICALCL Gene

Q6ZW33-MICLK_HUMAN
The poly-Pro region of MICALCL is polymorphic

Sequence variations from dbSNP and Humsavar for MICALCL Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs8745 -- 12,362,008(+) CTGCT(C/G)AGTAG utr-variant-3-prime
rs881384 -- 12,341,832(-) CTTTT(C/T)TTTTT intron-variant
rs903209 -- 12,286,953(+) GAGAG(A/G)GTTCA utr-variant-5-prime, upstream-variant-2KB
rs903213 -- 12,323,912(-) ATATC(A/G)TTATA intron-variant
rs977494 -- 12,305,706(+) tgagg(A/C)aagtg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MICALCL Gene

Variant ID Type Subtype PubMed ID
nsv522844 CNV Loss 19592680
nsv527449 CNV Gain 19592680
esv275255 CNV Loss 21479260
esv2744117 CNV Deletion 23290073

Relevant External Links for MICALCL Gene

HapMap Linkage Disequilibrium report
MICALCL
Human Gene Mutation Database (HGMD)
MICALCL

Disorders for MICALCL Gene

Relevant External Links for MICALCL

Genetic Association Database (GAD)
MICALCL
Human Genome Epidemiology (HuGE) Navigator
MICALCL
genes like me logo Genes that share disorders with MICALCL: view

No data available for UniProtKB/Swiss-Prot for MICALCL Gene

Publications for MICALCL Gene

  1. MICALs, a family of conserved flavoprotein oxidoreductases, function in plexin-mediated axonal repulsion. (PMID: 12110185) Terman J.R. … Kolodkin A.L. (Cell 2002) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  4. Quantitative Lys-I/-Gly-Gly (diGly) proteomics coupled with inducible RNAi reveals ubiquitin-mediated proteolysis of DNA damage-inducible transcript 4 (DDIT4) by the E3 ligase HUWE1. (PMID: 25147182) Thompson J.W. … Luchansky S.J. (J. Biol. Chem. 2014) 3
  5. Genome-wide association study of electrocardiographic and heart rate variability traits: the Framingham Heart Study. (PMID: 17903306) Newton-Cheh C. … Larson M.G. (BMC Med. Genet. 2007) 48

Products for MICALCL Gene

Sources for MICALCL Gene

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