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Aliases for MICALCL Gene

Aliases for MICALCL Gene

  • MICAL C-Terminal Like 2 3 5
  • ERK2-Binding Testicular Protein 1 3 4
  • Ebitein-1 3 4
  • Mical-CL 3 4
  • MICAL C-Terminal-Like Protein 3
  • Ebitein1 3

External Ids for MICALCL Gene

Previous GeneCards Identifiers for MICALCL Gene

  • GC11P012272
  • GC11P011984

Summaries for MICALCL Gene

GeneCards Summary for MICALCL Gene

MICALCL (MICAL C-Terminal Like) is a Protein Coding gene. GO annotations related to this gene include mitogen-activated protein kinase binding. An important paralog of this gene is MICAL3.

UniProtKB/Swiss-Prot for MICALCL Gene

  • May cooperate with MAPK1/ERK2 via an intracellular signal transduction pathway in the morphogenetic development of round spermatids to spermatozoa. May act as Rab effector protein and play a role in vesicle trafficking.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MICALCL Gene

Genomics for MICALCL Gene

Regulatory Elements for MICALCL Gene

Enhancers for MICALCL Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G012218 1.5 Ensembl ENCODE dbSUPER 21.6 -53.9 -53930 7.5 PKNOX1 FOXA2 ZBTB7B YY1 TCF12 GATA2 FOS SP5 PPARG MBD2 MICALCL MICAL2 ENSG00000254680 GC11P012216
GH11G012073 1.9 FANTOM5 Ensembl ENCODE dbSUPER 13.5 -198.8 -198794 7.3 HDGF ARNT SIN3A BRCA1 TCF12 GATA2 ZNF548 FOS ZNF592 SMARCA4 ENSG00000255400 MICALCL MICAL2 PARVA DKK3 ENSG00000254991
GH11G012241 1.4 Ensembl ENCODE dbSUPER 17.4 -32.7 -32677 3.5 ATF1 CBX3 RAD21 TCF12 GATA2 CBX5 FOS MIER1 ZBTB2 ZBTB11 MICALCL MICAL2 ENSG00000254680 GC11P012216
GH11G012246 1.4 Ensembl ENCODE dbSUPER 17.3 -27.4 -27386 3.5 FOXA2 NFIB SIN3A ZBTB7B RARA ZNF335 SCRT2 RCOR1 ZHX2 CEBPB MICALCL MICAL2 ENSG00000254680 GC11P012216
GH11G012252 1.2 ENCODE dbSUPER 17.6 -22.4 -22353 2.1 HDGF YY1 TCF12 GATA2 ELK1 FOS ZNF592 MEF2D CREB3 MBD2 MICALCL MICAL2 ENSG00000254680 GC11P012216
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MICALCL on UCSC Golden Path with GeneCards custom track

Genomic Location for MICALCL Gene

Chromosome:
11
Start:
12,276,080 bp from pter
End:
12,359,144 bp from pter
Size:
83,065 bases
Orientation:
Plus strand

Genomic View for MICALCL Gene

Genes around MICALCL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MICALCL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MICALCL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MICALCL Gene

Proteins for MICALCL Gene

  • Protein details for MICALCL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZW33-MICLK_HUMAN
    Recommended name:
    MICAL C-terminal-like protein
    Protein Accession:
    Q6ZW33
    Secondary Accessions:
    • Q7RTP7
    • Q96JU6

    Protein attributes for MICALCL Gene

    Size:
    695 amino acids
    Molecular mass:
    77277 Da
    Quaternary structure:
    • Interacts with MAPK1/ERK2 (By similarity). Interacts with RAB1B, RAB35, RAB8A, RAB10, RAB13 and RAB15 (in their GTP-bound forms); binding to RAB1B and RAB35 is of low affinity compared to other Rab proteins; at least in case of RAB8A may bind 2 molecules of RAB8A simultaneously through a high and a low affinity binding site, respectively.
    SequenceCaution:
    • Sequence=BAB55422.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MICALCL Gene

neXtProt entry for MICALCL Gene

Post-translational modifications for MICALCL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MICALCL Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MICALCL Gene

Domains & Families for MICALCL Gene

Protein Domains for MICALCL Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MICALCL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6ZW33

UniProtKB/Swiss-Prot:

MICLK_HUMAN :
  • The C-terminal RAB-binding domain (RBD), also described as bivalent Mical/EHBP Rab binding (bMERB) domain, mediates binding to predominantly Rab8, Rab10, Rab10, Rab13 and Rab15 (in their GTP-bound forms).
  • Belongs to the ebitein family.
Domain:
  • The C-terminal RAB-binding domain (RBD), also described as bivalent Mical/EHBP Rab binding (bMERB) domain, mediates binding to predominantly Rab8, Rab10, Rab10, Rab13 and Rab15 (in their GTP-bound forms).
Family:
  • Belongs to the ebitein family.
genes like me logo Genes that share domains with MICALCL: view

No data available for Gene Families for MICALCL Gene

Function for MICALCL Gene

Molecular function for MICALCL Gene

UniProtKB/Swiss-Prot Function:
May cooperate with MAPK1/ERK2 via an intracellular signal transduction pathway in the morphogenetic development of round spermatids to spermatozoa. May act as Rab effector protein and play a role in vesicle trafficking.

Gene Ontology (GO) - Molecular Function for MICALCL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051019 mitogen-activated protein kinase binding ISS --
genes like me logo Genes that share ontologies with MICALCL: view

Phenotypes for MICALCL Gene

genes like me logo Genes that share phenotypes with MICALCL: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MICALCL Gene

Localization for MICALCL Gene

Subcellular locations from UniProtKB/Swiss-Prot for MICALCL Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MICALCL gene
Compartment Confidence
nucleus 4
plasma membrane 2
cytosol 2

Gene Ontology (GO) - Cellular Components for MICALCL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm ISS --
genes like me logo Genes that share ontologies with MICALCL: view

Pathways & Interactions for MICALCL Gene

SuperPathways for MICALCL Gene

No Data Available

Interacting Proteins for MICALCL Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000256186%0d%0a9606.ENSP00000300935%0d%0a9606.ENSP00000264710%0d%0a9606.ENSP00000310226%0d%0a
Selected Interacting proteins: Q6ZW33-MICLK_HUMAN ENSP00000256186 for MICALCL Gene via IID STRING

Gene Ontology (GO) - Biological Process for MICALCL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0007283 spermatogenesis IEA --
GO:0008150 biological_process ND --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with MICALCL: view

No data available for Pathways by source and SIGNOR curated interactions for MICALCL Gene

Transcripts for MICALCL Gene

mRNA/cDNA for MICALCL Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(14) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MICALCL Gene

MICAL C-terminal like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MICALCL Gene

No ASD Table

Relevant External Links for MICALCL Gene

GeneLoc Exon Structure for
MICALCL
ECgene alternative splicing isoforms for
MICALCL

Expression for MICALCL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MICALCL Gene

mRNA differential expression in normal tissues according to GTEx for MICALCL Gene

This gene is overexpressed in Testis (x12.3), Skin - Sun Exposed (Lower leg) (x8.0), and Skin - Not Sun Exposed (Suprapubic) (x7.9).

Protein differential expression in normal tissues from HIPED for MICALCL Gene

This gene is overexpressed in Plasma (58.5) and Adipocyte (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MICALCL Gene



Protein tissue co-expression partners for MICALCL Gene

NURSA nuclear receptor signaling pathways regulating expression of MICALCL Gene:

MICALCL

SOURCE GeneReport for Unigene cluster for MICALCL Gene:

Hs.128196

Evidence on tissue expression from TISSUES for MICALCL Gene

  • Thyroid gland(4.1)
genes like me logo Genes that share expression patterns with MICALCL: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MICALCL Gene

Orthologs for MICALCL Gene

This gene was present in the common ancestor of animals.

Orthologs for MICALCL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MICALCL 35 34
  • 98.94 (n)
OneToOne
cow
(Bos Taurus)
Mammalia MICALCL 35 34
  • 80.88 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Micalcl 34
  • 74.52 (n)
mouse
(Mus musculus)
Mammalia Micalcl 35 16 34
  • 74.26 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MICALCL 35
  • 44 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta MICAL-like 35
  • 14 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1030 35
  • 23 (a)
OneToOne
Species where no ortholog for MICALCL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MICALCL Gene

ENSEMBL:
Gene Tree for MICALCL (if available)
TreeFam:
Gene Tree for MICALCL (if available)

Paralogs for MICALCL Gene

(1) SIMAP similar genes for MICALCL Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MICALCL: view

Variants for MICALCL Gene

Sequence variations from dbSNP and Humsavar for MICALCL Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000047703 -- 12,325,641(+) TCACG(G/T)GAGCA intron-variant
rs1000089213 -- 12,298,648(+) TTATC(A/G)TTTGG intron-variant
rs1000120797 -- 12,320,578(+) AAATG(C/T)TTCCC intron-variant
rs1000138789 -- 12,343,133(+) CTGGG(A/C/T)GCCGT intron-variant
rs1000141321 -- 12,337,787(+) CCTGA(A/C/G)TTCTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MICALCL Gene

Variant ID Type Subtype PubMed ID
dgv1059n100 CNV gain 25217958
esv2744117 CNV deletion 23290073
esv275255 CNV loss 21479260
esv3350761 CNV insertion 20981092
esv3579370 CNV loss 25503493
esv3625390 CNV gain 21293372
esv3625391 CNV gain 21293372
nsv1039617 CNV loss 25217958
nsv483000 CNV loss 15286789
nsv522844 CNV loss 19592680
nsv527449 CNV gain 19592680
nsv553547 CNV loss 21841781

Variation tolerance for MICALCL Gene

Residual Variation Intolerance Score: 97.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.88; 74.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MICALCL Gene

Human Gene Mutation Database (HGMD)
MICALCL
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MICALCL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MICALCL Gene

Disorders for MICALCL Gene

Relevant External Links for MICALCL

Genetic Association Database (GAD)
MICALCL
Human Genome Epidemiology (HuGE) Navigator
MICALCL
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MICALCL

No disorders were found for MICALCL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MICALCL Gene

Publications for MICALCL Gene

  1. MICALs, a family of conserved flavoprotein oxidoreductases, function in plexin-mediated axonal repulsion. (PMID: 12110185) Terman J.R. … Kolodkin A.L. (Cell 2002) 2 3 4 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. bMERB domains are bivalent Rab8 family effectors evolved by gene duplication. (PMID: 27552051) Rai A. … Muller M.P. (Elife 2016) 4 64
  5. Genome-wide association study of electrocardiographic and heart rate variability traits: the Framingham Heart Study. (PMID: 17903306) Newton-Cheh C. … Larson M.G. (BMC Med. Genet. 2007) 46 64

Products for MICALCL Gene

Sources for MICALCL Gene

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