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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MICALCL Gene

protein-coding   GIFtS: 46
GCID: GC11P012272

MICAL C-Terminal Like

  Search for MICALCL
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
MICAL C-Terminal Like1 2     MICAL C-Terminal-Like Protein2
ERK2-Binding Testicular Protein 12 3     Ebitein-13
Ebitein12     EBITEIN15
ebitein-12     

External Ids:    HGNC: 259331   Entrez Gene: 849532   Ensembl: ENSG000001338087   OMIM: 6123555   UniProtKB: Q6ZW333   

Export aliases for MICALCL gene to outside databases

Previous GC identifer: GC11P011984


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for MICALCL Gene: 
MICALCL (MICAL C-terminal like) is a protein-coding gene. GO annotations related to this gene include mitogen-activated protein kinase binding. An important paralog of this gene is MICALL2.

UniProtKB/Swiss-Prot: MICLK_HUMAN, Q6ZW33
Function: May cooperate with MAPK1/ERK2 via an intracellular signal transduction pathway in the morphogenetic
development of round spermatids to spermatozoa (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_009237.18  NC_018922.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MICALCL gene promoter:
         GR   NRSF form 1   GR-beta   RREB-1   NRSF form 2   SREBP-1b   FOXL1   SREBP-1a   HSF2   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMICALCL promoter sequence
   Search SABiosciences Chromatin IP Primers for MICALCL

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MICALCL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.3   Ensembl cytogenetic band:  11p15.3   HGNC cytogenetic band: 11p15.3

MICALCL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MICALCL gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P012272:  view genomic region     (about GC identifiers)

Start:
12,297,627 bp from pter      End:
12,380,691 bp from pter
Size:
83,065 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MICLK_HUMAN, Q6ZW33 (See protein sequence)
Recommended Name: MICAL C-terminal-like protein  
Size: 695 amino acids; 77277 Da
Subunit: Interacts with MAPK1/ERK2 (By similarity)
Subcellular location: Cytoplasm (By similarity)
Sequence caution: Sequence=BAB55422.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q7RTP7 Q96JU6

Explore the universe of human proteins at neXtProt for MICALCL: NX_Q6ZW33

Explore proteomics data for MICALCL at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6ZW33

  • MICALCL Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MICALCL Protein Expression
    REFSEQ proteins: NP_116256.2  
    ENSEMBL proteins: 
     ENSP00000432324   ENSP00000256186  

    Human Recombinant Protein Products for MICALCL: 
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    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ISS--

    MICALCL for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR022735 DUF3585

    Graphical View of Domain Structure for InterPro Entry Q6ZW33

    ProtoNet protein and cluster: Q6ZW33

    UniProtKB/Swiss-Prot: MICLK_HUMAN, Q6ZW33
    Similarity: Belongs to the ebitein family


    MICALCL for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MICLK_HUMAN, Q6ZW33
    Function: May cooperate with MAPK1/ERK2 via an intracellular signal transduction pathway in the morphogenetic
    development of round spermatids to spermatozoa (By similarity)

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0051019mitogen-activated protein kinase binding ISS--
         
    MICALCL for ontologies           About GeneDecksing


    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidMICALCL 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MICALCL

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for MICALCL (Q6ZW333 ENSP000002561864) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RAB1BQ9H0U43, ENSP000003102264I2D: score=2 STRING: ENSP00000310226
    RAB19ENSP000002758744STRING: ENSP00000275874
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007275multicellular organismal development IEA--
    GO:0007283spermatogenesis IEA--
    GO:0008150biological_process ND--
    GO:0030154cell differentiation IEA--

    MICALCL for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MICALCL (MICLK)

    Search CenterWatch for drugs/clinical trials and news about MICALCL / MICLK

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MICALCL gene: 
    NM_032867.2  

    Unigene Cluster for MICALCL:

    MICAL C-terminal like
    Hs.128196  [show with all ESTs]
    Unigene Representative Sequence: NM_032867
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000529028 ENST00000533534 ENST00000256186(uc001mkg.1)
    miRNA
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    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate MICALCL (see all 10):
    hsa-miR-875-3p hsa-miR-3924 hsa-miR-105 hsa-miR-4261 hsa-miR-656 hsa-miR-183* hsa-miR-380 hsa-miR-1299
    SwitchGear 3'UTR luciferase reporter plasmidMICALCL 3' UTR sequence
    Inhib. RNA
    Products:
         
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MICALCL
    Clone
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MICALCL
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MICALCL

    Additional mRNA sequence: 

    AK027872.1 AK123671.1 

    1 DOTS entry:

    DT.40272671 

    14 AceView cDNA sequences:

    AI243524 BX110865 BK000463 BG231646 NM_032867 AA398705 AK027872 AK123671 
    AA397753 AI709131 AA781360 AA972262 AA393676 BX107381 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MICALCL expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCAGCTTCCC
    MICALCL Expression
    About this image


    See MICALCL Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MICALCL

    SOURCE GeneReport for Unigene cluster: Hs.128196
        SABiosciences Custom PCR Arrays for MICALCL
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MICALCL

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for MICALCL gene from 2/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Micalcl1 , 5 MICAL C-terminal like1, 5 74.45(n)1
    65.69(a)1
      7 (58.75 cM)5
    1005041951  NM_027587.21  NP_081863.21 
     1123743455 
    zebrafish
    (Danio rerio)
    Actinopterygii CF595241.12   -- 76.22(n)    CF595241.1 


    ENSEMBL Gene Tree for MICALCL (if available)
    TreeFam Gene Tree for MICALCL (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MICALCL gene
    MICALL22  MICAL22  EHBP12  MICAL32  SPECC12  SMTNL22  MICALL12  MICAL12  
    SMTN2  EHBP1L12  SPECC1L2  ENSG000002585552  SMTNL12  
    1 SIMAP similar gene for MICALCL using alignment to 2 protein entries:     MICLK_HUMAN (see all proteins):
    MICALL1

    MICALCL for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: MICLK_HUMAN, Q6ZW33
    Polymorphism: The poly-Pro region of MICALCL is polymorphic


    10/1801 SNPs in MICALCL are shown (see all 1801)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs47573361,2
    C,F,A,H--12306459(+) CCCGAC/AGGGTT 1 -- us2k112Minor allele frequency- A:0.43NA WA CSA EA 378
    rs1450740351,2
    C--12306505(+) AAGAC-/AGGGGAA 1 -- us2k10--------
    rs122821501,2
    C,F,A--12306613(+) TCAGGA/G/TTTTTT 1 -- us2k110WA NA CSA EA 374
    rs800016821,2
    C,F--12306646(+) GTTCGG/AAAAAT 1 -- us2k11Minor allele frequency- A:0.07EA 120
    rs1895795551,2
    --12306728(+) TTCCTA/GAGTGG 1 -- us2k10--------
    rs1445782441,2
    C--12306731(+) TGAGT-/GGGGGG 1 -- us2k10--------
    rs122822671,2
    C,F--12306765(+) tatcaA/Gtctag 1 -- us2k13Minor allele frequency- G:0.09WA NA EA 358
    rs1917683221,2
    --12306777(+) TGGTGC/GCAGTT 1 -- us2k10--------
    rs1846932541,2
    --12306855(+) AGCCTC/TAAGAT 1 -- us2k10--------
    rs1889869191,2
    --12306863(+) GATGCA/CATTTG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for MICALCL (12297627 - 12380691 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for MICALCL:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2744117CNV Deletion23290073
    esv275255CNV Loss21479260
    nsv522844CNV Loss19592680
    nsv527449CNV Gain19592680


    Human Gene Mutation Database (HGMD): MICALCL
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing MICALCL
    DNA2.0 Custom Variant and Variant Library Synthesis for MICALCL

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    MICALCL for disorders           About MalaCards
    OMIM gene information: 612355    OMIM disorders: --


    MICALCL for disorders           About GeneDecksing

    Genetic Association Database (GAD): MICALCL
    Human Genome Epidemiology (HuGE) Navigator: MICALCL (1 document)

    Export disorders for MICALCL gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MICALCL gene integrated from 9 sources:
    (articles sorted by number of sources associating them with MICALCL)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. MICALs, a family of conserved flavoprotein oxidoreductases, function in plexin-mediated axonal repulsion. (PubMed id 12110185)1, 2, 3 Terman J.R.... Kolodkin A.L. (2002)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Genome-wide association study of electrocardiographic and heart rate variability traits: the Framingham Heart Study. (PubMed id 17903306)4 Newton-Cheh C....Larson M.G. (2007)
    5. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)2 Taylor T.D....Sakaki Y. (2006)
    6. The MICAL proteins and rab1: a possible link to the cytoskeleton? (PubMed id 15694364)1 Fischer J.... Barnekow A. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 84953 HGNC: 25933 AceView: FLJ14966 Ensembl:ENSG00000133808 euGenes: HUgn84953
    ECgene: MICALCL H-InvDB: MICALCL

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MICALCL Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MICALCL gene:
    Search GeneIP for patents involving MICALCL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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