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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MICAL3 Gene

protein-coding   GIFtS: 48
GCID: GC22M018271

microtubule associated monoxygenase, calponin and LIM domain...
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Aliases
for MICAL3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Microtubule Associated Monoxygenase, Calponin And LIM Domain Containing
31 2
     Flavoprotein Oxidoreductase MICAL32
KIAA08191 3     Protein MICAL-32
Molecule Interacting With CasL Protein 32 3     Protein-Methionine Sulfoxide Oxidase MICAL32
MICAL-32 3     EC 1.14.13.-3
KIAA13643 5     

External Ids:    HGNC: 246941   Entrez Gene: 575532   Ensembl: ENSG000002431567   OMIM: 6088825   UniProtKB: Q7RTP63   

Export aliases for MICAL3 gene to outside databases

Previous GC identifers: GC22M016696 GC22M016697 GC22M016691 GC22M016650 GC22M002084


Summaries
for MICAL3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: MICA3_HUMAN, Q7RTP6
Function: Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine
residues on actin. Acts by modifying actin subunits through the addition of oxygen to form methionine-sulfoxide,
leading to promote actin filament severing and prevent repolymerization (By similarity). Involved in exocytic vesicles
tethering and fusion: the monooxygenase activity is required for this process

Gene Wiki entry for MICAL3


Genomic Views
for MICAL3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NC_018933.1  NT_011519.10  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MICAL3 gene promoter:
         STAT5B   ER-alpha   GATA-3   STAT5A   RORalpha2   GATA-1   GATA-2   RORalpha1   POU2F1   HSF2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for MICAL3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MICAL3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q11.21   Ensembl cytogenetic band:  22q11.21   HGNC cytogenetic band: 22q11.21

MICAL3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MICAL3 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M018271:  view genomic region     (about GC identifiers)

Start:
 18,270,415 bp from pter      End:
 18,507,325 bp from pter
Size:
 236,911 bases      Orientation:
 minus strand

Proteins
for MICAL3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MICA3_HUMAN, Q7RTP6 (See protein sequence)
Recommended Name: Protein-methionine sulfoxide oxidase MICAL3  
Size: 2002 amino acids; 224295 Da
Cofactor: FAD (By similarity)
Subunit: Interacts with RAB1B. Interacts with ERC1 and RAB8A
Subcellular location: Cytoplasm. Cytoplasm, cytoskeleton
1 PDB 3D structure from and Proteopedia for MICAL3:
2D88 (3D)    
Secondary accessions: B2RXJ5 E9PEF0 O94909 Q5U4P4 Q6ICK4 Q96DF2 Q9P2I3
Alternative splicing: 5 isoforms:  Q7RTP6-1   Q7RTP6-2   Q7RTP6-3   Q7RTP6-4   Q7RTP6-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MICAL3: NX_Q7RTP6

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q7RTP6

    • MICAL3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001116203.1  NP_001129476.1  NP_056056.2  

    ENSEMBL proteins: 
     ENSP00000416015   ENSP00000463882   ENSP00000462107   ENSP00000462905   ENSP00000464007  
     ENSP00000463453   ENSP00000383406   ENSP00000434678   ENSP00000391827   ENSP00000372574  
     ENSP00000462531   ENSP00000462033   ENSP00000406193   ENSP00000410315   ENSP00000207726  
     ENSP00000414846  

    Human Recombinant Protein Products: 
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    Novus Biologicals MICAL3 Proteins
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for MICAL3

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005856cytoskeleton IEA--


    MICAL3 for ontologies           About GeneDecksing



    MICAL3 Antibody Products: 
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    Uscn Antibodies for MICAL3
    Search ThermoFisher Antibodies for MICAL3

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    Uscn ELISAs and CLIAs for MICAL3

    Protein Domains /
    Families
    for MICAL3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MICAL3 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR003042 Rng_hydrolase-like
     IPR022735 DUF3585
     IPR002938 mOase_FAD-bd
     IPR001715 CH-domain
     IPR001781 Znf_LIM

    Graphical View of Domain Structure for InterPro Entry Q7RTP6

    ProtoNet protein and cluster: Q7RTP6

    3 Blocks protein families:
    IPB001715 Calponin-like actin-binding
    IPB001781 Zn-binding protein
    IPB002938 Monooxygenase


    UniProtKB/Swiss-Prot: MICA3_HUMAN, Q7RTP6
    Similarity: Belongs to the Mical family
    Similarity: Contains 1 CH (calponin-homology) domain
    Similarity: Contains 1 LIM zinc-binding domain


    Function
    for MICAL3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: MICA3_HUMAN, Q7RTP6
    Function: Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine
    residues on actin. Acts by modifying actin subunits through the addition of oxygen to form methionine-sulfoxide,
    leading to promote actin filament severing and prevent repolymerization (By similarity). Involved in exocytic vesicles
    tethering and fusion: the monooxygenase activity is required for this process
    Catalytic activity: [protein]-methionine + NADPH + O(2) = [protein]-methionine-sulfoxide + NADP(+) + H(2)O

    Enzyme Number (IUBMB): EC 1.14.13.-1

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MICAL3
    8/98 QIAGEN miScript miRNA Assays for microRNAs that regulate MICAL3 (see all 98):
    hsa-miR-140-5p hsa-miR-579 hsa-miR-3607-3p hsa-miR-520e hsa-miR-106a hsa-miR-218-1* hsa-miR-128 hsa-miR-30d
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene shRNA RFP: MICAL3
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MICAL3

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for MICAL3

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MICAL3 (see all 5)
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    Cell Line
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    Search LifeMap BioReagents cell lines for MICAL3

    In Situ Assay
    Products:       
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    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding ISS--
    GO:0008270zinc ion binding IEA--
    GO:0016491oxidoreductase activity ----
    GO:0016709oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen ISS--
    GO:0071949FAD binding ISS--


    MICAL3 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for MICAL3:
     Synthetic lethal with Ras 


    Pathways & Interactions
    for MICAL3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MICAL3

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    3 Interacting proteins for MICAL3 (Q7RTP63 ENSP000004160154) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAP2K5Q131633I2D: score=1 
    RAB1BQ9H0U43I2D: score=1 
    RAB19ENSP000002758744STRING: ENSP00000275874
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006887exocytosis IEA--
    GO:0030042actin filament depolymerization ISS--
    GO:0055114oxidation-reduction process ISS--


    MICAL3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for MICAL3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MICAL3

    1 HMDB Compound for MICAL3    About this table
    CompoundSynonyms CAS #PubMed Ids
    FAD1H-Purin-6-amine flavin dinucleotide (see all 21)146-14-5--
    Search CenterWatch for drugs/clinical trials and news about MICAL3 / MICA3 

    Transcripts
    for MICAL3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MICAL3 gene (3 alternative transcripts): 
    NM_001122731.1  NM_001136004.1  NM_015241.2  

    Unigene Cluster for MICAL3:

    Microtubule associated monoxygenase, calponin and LIM domain containing 3
    Hs.528024  [show with all ESTs]
    Unigene Representative Sequence: NM_015241
    18/22 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 22):
    ENST00000441493(uc010grd.2 uc010gre.2 uc011agl.2 uc002zng.4)
    ENST00000252134 ENST00000580469 ENST00000577821 ENST00000579997 ENST00000584751
    ENST00000498573 ENST00000578984 ENST00000400561 ENST00000495076(uc002znl.1)
    ENST00000578905(uc021wkr.1) ENST00000414725(uc002znj.1 uc002znk.1)
    ENST00000383094 ENST00000461307 ENST00000585038 ENST00000462645 ENST00000465886
    ENST00000498345

    miRNA
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    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MICAL3
    8/98 QIAGEN miScript miRNA Assays for microRNAs that regulate MICAL3 (see all 98):
    hsa-miR-140-5p hsa-miR-579 hsa-miR-3607-3p hsa-miR-520e hsa-miR-106a hsa-miR-218-1* hsa-miR-128 hsa-miR-30d
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MICAL3 (see all 4)
    OriGene shRNA RFP: MICAL3
    OriGene siRNA: MICAL3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MICAL3
    Clone
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    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MICAL3

    Additional cDNA sequence: 

    AB020626.1 AB037785.1 AK023678.1 AK025369.1 AK094822.1 AK124853.1 AK126925.1 AK127487.1 
    AK289506.1 AK295978.1 AL833711.1 BC006562.2 BC035213.1 BC046364.1 BC047315.1 BC064400.1 
    BC085009.1 BC115391.1 BC157876.1 BC171887.1 BX647382.1 CR456364.1 

    24/26 DOTS entries (see all 26):

    DT.216356  DT.91679436  DT.75158209  DT.95219234  DT.432528  DT.99944673  DT.95242805  DT.75100235 
    DT.91840877  DT.101983874  DT.102830481  DT.120650071  DT.120650037  DT.446715  DT.92430275  DT.97803489 
    DT.100729427  DT.120650035  DT.120650212  DT.75183110  DT.91738402  DT.95282093  DT.421580  DT.440373 

    24/87 AceView cDNA sequences (see all 87):

    H55689 BQ215559 BX507656 BK000464 BQ947694 AB037785 BX647382 BU158020 
    AI392850 Z41052 CR456364 F13172 F10778 AW452613 BM987643 AK055433 
    BX488498 BQ340209 BU617485 BX643501 AK094822 AK124853 BF055090 BU633987 

    GeneLoc Exon Structure


    Expression
    for MICAL3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MICAL3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See MICAL3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MICAL3

    SOURCE GeneReport for Unigene cluster: Hs.528024

    UniProtKB/Swiss-Prot: MICA3_HUMAN, Q7RTP6
    Tissue specificity: Ubiquitous

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    In Situ
    Assay Products:     
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    Orthologs
    for MICAL3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for MICAL3 gene from 4/17 species (see all 17)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves MICAL31 microtubule associated monoxygenase, calponin and LIM more 73.9(n)
    79.12(a)    		   418164  XM_416395.3  XP_416395.3 
    lizard
    (Anolis carolinensis)    		 Reptilia MICAL36
    		 --
    		 76(a)
    		 1 ↔ 1
    		 5(14095089-14197119)
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.147682 Danio rerio cDNA clone IMAGE4786938, partial cds 78.63(n)    BC059615.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Mical6
    		 Molecule interacting with CasL
    		 10(a)
    		 1 → many
    		 3R(5827276-5868617)


    ENSEMBL Gene Tree for MICAL3 (if available)
    TreeFam Gene Tree for MICAL3 (if available) 

    Paralogs
    for MICAL3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MICAL3 gene
    MICALL22  MICALL12  MICAL22  MICALCL2  MICAL12  EHBP12  EHBP1L12  
    7 SIMAP similar genes for MICAL3 using alignment to 9 protein entries:     MICA3_HUMAN (see all proteins):
    MICAL2    ACTN1    MICAL1    MICALL1    CRIP1    CRIP2
    LIMD2

    MICAL3 for paralogs           About GeneDecksing



    Genomic Variants
    for MICAL3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/5362 NCBI SNPs in MICAL3 are shown (see all 5362)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 22 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs121604291,2
    		C--2173661(+) GGGAGC/GTTATG 1 -- int11Minor allele frequency- G:0.00NA 2
    rs622405631,2
    		C--2173728(+) AGTTAG/TGGAGG 1 -- int11Minor allele frequency- T:0.50NA 2
    rs1920393811,2
    		--18269959(+) CTAACA/GAGCAG 1 -- int10--------
    rs1404885061,2
    		--18270286(+) AAGCAC/TGAACT 1 -- int10--------
    rs22897141,2
    		C,H,--18270339(+) AGGCAC/TGAGCT 1 -- int15Minor allele frequency- T:0.00EA NS 1922
    rs1876228841,2
    		--18270589(+) TGGCCA/GCCAGG 1 -- ut310--------
    rs76751,2
    		C,F,O,A,--18270779(+) TTATGC/TGTGTG 1 -- ut3110Minor allele frequency- T:0.18MN NA WA EA 872
    rs1928661381,2
    		--18270847(+) GAAAAC/TCTGCC 1 -- ut310--------
    rs801623851,2
    		C--18270952(+) GCTTT-/AAAAAA 1 -- ut310--------
    rs1849500751,2
    		--18270958(+) AAAAAA/TAGTGC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for MICAL3 (18270415 - 18507325 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 43 variations for MICAL3
         15/29 CNVs (see all 29): 79431 79434 103130 90870 90863 79441 79429 103131 79436 90872 5167 90868 90865 90875 67831
         14 Indels: 46204 79440 90876 27018 27017 42958 46201 79439 90871 79438 46202 79426 46203 90864

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MICAL3
    DNA2.0 Custom Variant and Variant Library Synthesis for MICAL3

    Disorders / Diseases
    for MICAL3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MICAL3 for disorders           About MalaCards

    MICAL3 for disorders           About GeneDecksing

    OMIM gene information: 608882    OMIM disorders: --

    Human Genome Epidemiology (HuGE) Navigator: MICAL3 (1 document)

    Export disorders for MICAL3 gene to outside databases

    Publications
    for MICAL3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MICAL3 gene, integrated from 9 sources (see all 27):
    (articles sorted by number of sources associating them with MICAL3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. MICALs, a family of conserved flavoprotein oxidoreductases, function in plexin-mediated axonal repulsion. (PubMed id 12110185)1, 2, 3 Terman J.R.... Kolodkin A.L. (2002)
    2. Rab6, Rab8, and MICAL3 cooperate in controlling docki ng and fusion of exocytotic carriers. (PubMed id 21596566)1, 2 Grigoriev I....Akhmanova A. (2011)
    3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    4. The MICAL proteins and rab1: a possible link to the cytoskeleton? (PubMed id 15694364)1, 2 Fischer J.... Barnekow A. (2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (2004)
    7. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2 Nagase T.... Ohara O. (2000)
    8. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I....O'Brien K.P. (1999)
    9. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
    10. Allelic expression analysis of the osteoarthritis susc eptibility locus that maps to MICAL3. (PubMed id 22385522)1 Ratnayake M....Loughlin J. (2012)

    External Searches for MICAL3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing MICAL3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57553 HGNC: 24694 AceView: MICAL3 Ensembl:ENSG00000243156 euGenes: HUgn57553
    ECgene: MICAL3 H-InvDB: MICAL3

    Other Databases showing MICAL3 gene

    (According to HUGE)
    About This Section
    HUGE: KIAA0819 KIAA1364

    Specialized Databases showing MICAL3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MICAL3 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for MICAL3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MICAL3 gene:
    Search GeneIP for patents involving MICAL3

    GeneCards and IP:
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