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Aliases for MICAL3 Gene

Aliases for MICAL3 Gene

  • Microtubule Associated Monooxygenase, Calponin And LIM Domain Containing 3 2 3 5
  • Molecule Interacting With CasL Protein 3 3 4
  • MICAL-3 3 4
  • Protein-Methionine Sulfoxide Oxidase MICAL3 3
  • Flavoprotein Oxidoreductase MICAL3 3
  • Protein MICAL-3 3
  • EC 1.14.13.- 4
  • KIAA0819 4
  • KIAA1364 4

External Ids for MICAL3 Gene

Previous GeneCards Identifiers for MICAL3 Gene

  • GC22M016696
  • GC22M016697
  • GC22M016691
  • GC22M016650
  • GC22M018271
  • GC22M002084

Summaries for MICAL3 Gene

GeneCards Summary for MICAL3 Gene

MICAL3 (Microtubule Associated Monooxygenase, Calponin And LIM Domain Containing 3) is a Protein Coding gene. GO annotations related to this gene include actin binding and Rab GTPase binding. An important paralog of this gene is MICAL2.

UniProtKB/Swiss-Prot for MICAL3 Gene

  • Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin. Acts by modifying actin subunits through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament severing and prevent repolymerization. Involved in exocytic vesicles tethering and fusion: the monooxygenase activity is required for this process.

Gene Wiki entry for MICAL3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MICAL3 Gene

Genomics for MICAL3 Gene

Regulatory Elements for MICAL3 Gene

Enhancers for MICAL3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around MICAL3 on UCSC Golden Path with GeneCards custom track

Promoters for MICAL3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MICAL3 on UCSC Golden Path with GeneCards custom track

Genomic Location for MICAL3 Gene

Chromosome:
22
Start:
17,787,649 bp from pter
End:
18,024,559 bp from pter
Size:
236,911 bases
Orientation:
Minus strand

Genomic View for MICAL3 Gene

Genes around MICAL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MICAL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MICAL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MICAL3 Gene

Proteins for MICAL3 Gene

  • Protein details for MICAL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7RTP6-MICA3_HUMAN
    Recommended name:
    Protein-methionine sulfoxide oxidase MICAL3
    Protein Accession:
    Q7RTP6
    Secondary Accessions:
    • B2RXJ5
    • E9PEF0
    • O94909
    • Q5U4P4
    • Q6ICK4
    • Q96DF2
    • Q9P2I3

    Protein attributes for MICAL3 Gene

    Size:
    2002 amino acids
    Molecular mass:
    224295 Da
    Cofactor:
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Quaternary structure:
    • Interacts with RAB1B. Interacts with ERC1 and RAB8A.

    Three dimensional structures from OCA and Proteopedia for MICAL3 Gene

    Alternative splice isoforms for MICAL3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MICAL3 Gene

Post-translational modifications for MICAL3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MICAL3 Gene

Domains & Families for MICAL3 Gene

Gene Families for MICAL3 Gene

Suggested Antigen Peptide Sequences for MICAL3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7RTP6

UniProtKB/Swiss-Prot:

MICA3_HUMAN :
  • Contains 1 CH (calponin-homology) domain.
  • Belongs to the Mical family.
Domain:
  • Contains 1 CH (calponin-homology) domain.
  • Contains 1 LIM zinc-binding domain.
Family:
  • Belongs to the Mical family.
genes like me logo Genes that share domains with MICAL3: view

Function for MICAL3 Gene

Molecular function for MICAL3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
[protein]-methionine + NADPH + O(2) = [protein]-methionine-sulfoxide + NADP(+) + H(2)O.
UniProtKB/Swiss-Prot Function:
Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin. Acts by modifying actin subunits through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament severing and prevent repolymerization. Involved in exocytic vesicles tethering and fusion: the monooxygenase activity is required for this process.

Enzyme Numbers (IUBMB) for MICAL3 Gene

Gene Ontology (GO) - Molecular Function for MICAL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding ISS --
GO:0008270 zinc ion binding IEA --
GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen ISS --
GO:0017137 Rab GTPase binding IEA --
GO:0071949 FAD binding ISS --
genes like me logo Genes that share ontologies with MICAL3: view
genes like me logo Genes that share phenotypes with MICAL3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for MICAL3

CRISPR Products

miRNA for MICAL3 Gene

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MICAL3 Gene

Localization for MICAL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MICAL3 Gene

Cytoplasm. Cytoplasm, cytoskeleton. Nucleus. Note=Mainly localizes in the nucleus. {ECO:0000269 PubMed:24440334}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MICAL3 Gene COMPARTMENTS Subcellular localization image for MICAL3 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
plasma membrane 4
cytosol 3
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for MICAL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 24440334
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005856 cytoskeleton IEA --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with MICAL3: view

Pathways & Interactions for MICAL3 Gene

SuperPathways for MICAL3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MICAL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006887 exocytosis IEA --
GO:0007010 cytoskeleton organization IDA 24440334
GO:0030042 actin filament depolymerization ISS --
GO:0055114 oxidation-reduction process ISS --
genes like me logo Genes that share ontologies with MICAL3: view

No data available for Pathways by source and SIGNOR curated interactions for MICAL3 Gene

Drugs & Compounds for MICAL3 Gene

(3) Drugs for MICAL3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
FAD Approved Pharma 0
Oxygen Approved, Vet_approved Pharma 0
Water Approved Pharma 0

(2) Additional Compounds for MICAL3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
NADP
  • Adenine-nicotinamide dinucleotide phosphate
  • b-NADP
  • b-Nicotinamide adenine dinucleotide phosphate
  • b-TPN
  • beta-NADP
53-59-8
nadph
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-D-ribofuranosyl-3-pyridinecarboxamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosyl-3-pyridinecarboxamide
  • b-NADPH
53-57-6
genes like me logo Genes that share compounds with MICAL3: view

Transcripts for MICAL3 Gene

Unigene Clusters for MICAL3 Gene

Microtubule associated monoxygenase, calponin and LIM domain containing 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MICAL3 Gene

No ASD Table

Relevant External Links for MICAL3 Gene

GeneLoc Exon Structure for
MICAL3
ECgene alternative splicing isoforms for
MICAL3

Expression for MICAL3 Gene

mRNA expression in normal human tissues for MICAL3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MICAL3 Gene

This gene is overexpressed in Blymphocyte (16.2), Fetal Brain (8.8), Frontal cortex (7.1), and Peripheral blood mononuclear cells (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MICAL3 Gene



Protein tissue co-expression partners for MICAL3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MICAL3 Gene:

MICAL3

SOURCE GeneReport for Unigene cluster for MICAL3 Gene:

Hs.528024

mRNA Expression by UniProt/SwissProt for MICAL3 Gene:

Q7RTP6-MICA3_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with MICAL3: view

Primer Products

No data available for mRNA differential expression in normal tissues for MICAL3 Gene

Orthologs for MICAL3 Gene

This gene was present in the common ancestor of animals.

Orthologs for MICAL3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MICAL3 34
  • 83.2 (n)
  • 84.25 (a)
MICAL3 35
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MICAL3 34
  • 86.74 (n)
  • 88.19 (a)
MICAL3 35
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mical3 34
  • 84.49 (n)
  • 87.61 (a)
Mical3 16
Mical3 35
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MICAL3 34
  • 98.58 (n)
  • 98.72 (a)
MICAL3 35
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mical3 34
  • 84.53 (n)
  • 87.76 (a)
oppossum
(Monodelphis domestica)
Mammalia MICAL3 35
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 55 (a)
OneToMany
-- 35
  • 94 (a)
OneToMany
-- 35
  • 67 (a)
OneToMany
-- 35
  • 55 (a)
OneToMany
-- 35
  • 39 (a)
OneToMany
chicken
(Gallus gallus)
Aves MICAL3 34
  • 72.37 (n)
  • 76.94 (a)
MICAL3 35
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MICAL3 35
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mical3 34
  • 67.39 (n)
  • 69.37 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.14768 34
mical3a 34
  • 66.43 (n)
  • 69.47 (a)
mical3a 35
  • 77 (a)
OneToMany
mical3a 35
  • 57 (a)
OneToMany
mical3b 35
  • 55 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Mical 35
  • 14 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 52 (a)
OneToMany
Species where no ortholog for MICAL3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MICAL3 Gene

ENSEMBL:
Gene Tree for MICAL3 (if available)
TreeFam:
Gene Tree for MICAL3 (if available)

Paralogs for MICAL3 Gene

genes like me logo Genes that share paralogs with MICAL3: view

Variants for MICAL3 Gene

Sequence variations from dbSNP and Humsavar for MICAL3 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs5992128 - 17,872,017(+) CTTCA(G/T)GGAGC nc-transcript-variant, reference, missense
rs11913706 - 17,906,782(+) AGCTG(C/G/T)GTTCA nc-transcript-variant, reference, missense
rs2289719 - 17,885,885(+) GTCTC(C/T)GTATG nc-transcript-variant, reference, missense
rs737830 -- 17,824,107(-) GGAGT(A/G)TGGGA intron-variant
rs737831 -- 17,824,046(-) TTGTC(A/G)AGGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MICAL3 Gene

Variant ID Type Subtype PubMed ID
dgv1279e212 CNV loss 25503493
dgv19e194 CNV deletion 18987734
dgv2430n106 CNV deletion 24896259
dgv2561e59 CNV duplication 20981092
dgv730e201 CNV deletion 23290073
dgv816e199 CNV deletion 23128226
esv1048298 CNV deletion 17803354
esv1410721 CNV deletion 17803354
esv1920921 CNV deletion 18987734
esv2421190 CNV deletion 18987734
esv2493326 CNV deletion 19546169
esv2543355 CNV deletion 19546169
esv2723954 CNV deletion 23290073
esv2723955 CNV deletion 23290073
esv2723957 CNV deletion 23290073
esv2723959 CNV deletion 23290073
esv2723960 CNV deletion 23290073
esv2723961 CNV deletion 23290073
esv275264 CNV loss 21479260
esv27985 CNV gain+loss 19812545
esv29318 CNV loss 19812545
esv3450955 CNV duplication 20981092
esv3557912 CNV deletion 23714750
esv3575408 CNV gain 25503493
esv3893428 CNV loss 25118596
esv3910 CNV loss 18987735
esv993104 CNV deletion 20482838
nsv1065486 CNV loss 25217958
nsv1072614 CNV deletion 25765185
nsv1109449 CNV deletion 24896259
nsv1112371 CNV deletion 24896259
nsv1148898 CNV deletion 26484159
nsv1153159 CNV deletion 26484159
nsv191257 CNV deletion 16902084
nsv3555 CNV insertion 18451855
nsv3556 CNV insertion 18451855
nsv428385 CNV gain+loss 18775914
nsv472319 CNV novel sequence insertion 20440878
nsv476144 CNV novel sequence insertion 20440878
nsv509806 CNV insertion 20534489
nsv526826 CNV gain 19592680
nsv527393 CNV loss 19592680
nsv588119 CNV loss 21841781
nsv834119 CNV loss 17160897
nsv834120 CNV loss 17160897
nsv834121 CNV gain 17160897
nsv955484 CNV deletion 24416366
nsv962752 CNV duplication 23825009

Variation tolerance for MICAL3 Gene

Residual Variation Intolerance Score: 78.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.11; 84.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MICAL3 Gene

Human Gene Mutation Database (HGMD)
MICAL3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MICAL3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MICAL3 Gene

Disorders for MICAL3 Gene

Relevant External Links for MICAL3

Genetic Association Database (GAD)
MICAL3
Human Genome Epidemiology (HuGE) Navigator
MICAL3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MICAL3

No disorders were found for MICAL3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MICAL3 Gene

Publications for MICAL3 Gene

  1. MICALs, a family of conserved flavoprotein oxidoreductases, function in plexin-mediated axonal repulsion. (PMID: 12110185) Terman J.R. … Kolodkin A.L. (Cell 2002) 2 3 4 65
  2. Redox modification of nuclear actin by MICAL-2 regulates SRF signaling. (PMID: 24440334) Lundquist M.R. … Jaffrey S.R. (Cell 2014) 3 4 65
  3. Rab6, Rab8, and MICAL3 cooperate in controlling docking and fusion of exocytotic carriers. (PMID: 21596566) Grigoriev I. … Akhmanova A. (Curr. Biol. 2011) 3 4 65
  4. Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. (PMID: 22001757) Chambers J.C. … Kooner J.S. (Nat. Genet. 2011) 3 46 65
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 65

Products for MICAL3 Gene

Sources for MICAL3 Gene

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