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Aliases for MICAL3 Gene

Aliases for MICAL3 Gene

  • Microtubule Associated Monooxygenase, Calponin And LIM Domain Containing 3 2 3 5
  • Molecule Interacting With CasL Protein 3 3 4
  • MICAL-3 3 4
  • Flavoprotein Oxidoreductase MICAL3 3
  • Protein MICAL-3 3
  • EC 1.14.13.- 4
  • KIAA0819 4
  • KIAA1364 4

External Ids for MICAL3 Gene

Previous GeneCards Identifiers for MICAL3 Gene

  • GC22M016696
  • GC22M016697
  • GC22M016691
  • GC22M016650
  • GC22M018271
  • GC22M002084

Summaries for MICAL3 Gene

GeneCards Summary for MICAL3 Gene

MICAL3 (Microtubule Associated Monooxygenase, Calponin And LIM Domain Containing 3) is a Protein Coding gene. GO annotations related to this gene include actin binding and Rab GTPase binding. An important paralog of this gene is SMTNL2.

UniProtKB/Swiss-Prot for MICAL3 Gene

  • Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin. Acts by modifying actin subunits through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament severing and prevent repolymerization. Involved in exocytic vesicles tethering and fusion: the monooxygenase activity is required for this process.

Gene Wiki entry for MICAL3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MICAL3 Gene

Genomics for MICAL3 Gene

Regulatory Elements for MICAL3 Gene

Enhancers for MICAL3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MICAL3 on UCSC Golden Path with GeneCards custom track

Promoters for MICAL3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MICAL3 on UCSC Golden Path with GeneCards custom track

Genomic Location for MICAL3 Gene

Chromosome:
22
Start:
17,787,649 bp from pter
End:
18,024,559 bp from pter
Size:
236,911 bases
Orientation:
Minus strand

Genomic View for MICAL3 Gene

Genes around MICAL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MICAL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MICAL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MICAL3 Gene

Proteins for MICAL3 Gene

  • Protein details for MICAL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7RTP6-MICA3_HUMAN
    Recommended name:
    Protein-methionine sulfoxide oxidase MICAL3
    Protein Accession:
    Q7RTP6
    Secondary Accessions:
    • B2RXJ5
    • E9PEF0
    • O94909
    • Q5U4P4
    • Q6ICK4
    • Q96DF2
    • Q9P2I3

    Protein attributes for MICAL3 Gene

    Size:
    2002 amino acids
    Molecular mass:
    224295 Da
    Cofactor:
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Quaternary structure:
    • Interacts with RAB1B. Interacts with ERC1 and RAB8A.

    Three dimensional structures from OCA and Proteopedia for MICAL3 Gene

    Alternative splice isoforms for MICAL3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MICAL3 Gene

Proteomics data for MICAL3 Gene at MOPED

Post-translational modifications for MICAL3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MICAL3 Gene

Domains & Families for MICAL3 Gene

Gene Families for MICAL3 Gene

Suggested Antigen Peptide Sequences for MICAL3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7RTP6

UniProtKB/Swiss-Prot:

MICA3_HUMAN :
  • Contains 1 CH (calponin-homology) domain.
  • Belongs to the Mical family.
Domain:
  • Contains 1 CH (calponin-homology) domain.
  • Contains 1 LIM zinc-binding domain.
Family:
  • Belongs to the Mical family.
genes like me logo Genes that share domains with MICAL3: view

Function for MICAL3 Gene

Molecular function for MICAL3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
[protein]-methionine + NADPH + O(2) = [protein]-methionine-sulfoxide + NADP(+) + H(2)O.
UniProtKB/Swiss-Prot Function:
Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin. Acts by modifying actin subunits through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament severing and prevent repolymerization. Involved in exocytic vesicles tethering and fusion: the monooxygenase activity is required for this process.

Enzyme Numbers (IUBMB) for MICAL3 Gene

Gene Ontology (GO) - Molecular Function for MICAL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding ISS --
GO:0005515 protein binding IEA --
GO:0016491 oxidoreductase activity IEA --
GO:0071949 FAD binding IEA,ISS --
genes like me logo Genes that share ontologies with MICAL3: view
genes like me logo Genes that share phenotypes with MICAL3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for MICAL3

miRNA for MICAL3 Gene

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MICAL3 Gene

Localization for MICAL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MICAL3 Gene

Cytoplasm. Cytoplasm, cytoskeleton. Nucleus. Note=Mainly localizes in the nucleus. {ECO:0000269 PubMed:24440334}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MICAL3 Gene COMPARTMENTS Subcellular localization image for MICAL3 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
plasma membrane 4
cytosol 3
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for MICAL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with MICAL3: view

Pathways & Interactions for MICAL3 Gene

SuperPathways for MICAL3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MICAL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007010 cytoskeleton organization IDA 24440334
GO:0055114 oxidation-reduction process IEA,ISS --
genes like me logo Genes that share ontologies with MICAL3: view

No data available for Pathways by source and SIGNOR curated interactions for MICAL3 Gene

Drugs & Compounds for MICAL3 Gene

(1) Drugs for MICAL3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
FAD Approved Pharma 0

(4) Additional Compounds for MICAL3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
NADP
  • Adenine-nicotinamide dinucleotide phosphate
  • b-NADP
  • b-Nicotinamide adenine dinucleotide phosphate
  • b-TPN
  • beta-NADP
53-59-8
nadph
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-D-ribofuranosyl-3-pyridinecarboxamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosyl-3-pyridinecarboxamide
  • b-NADPH
53-57-6
oxygen
  • Dioxygen
  • Molecular oxygen
  • O2
  • Oxygen
  • Oxygen molecule
7782-44-7
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with MICAL3: view

Transcripts for MICAL3 Gene

Unigene Clusters for MICAL3 Gene

Microtubule associated monoxygenase, calponin and LIM domain containing 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MICAL3 Gene

No ASD Table

Relevant External Links for MICAL3 Gene

GeneLoc Exon Structure for
MICAL3
ECgene alternative splicing isoforms for
MICAL3

Expression for MICAL3 Gene

mRNA expression in normal human tissues for MICAL3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MICAL3 Gene

This gene is overexpressed in Blymphocyte (16.2), Fetal Brain (8.8), Frontal cortex (7.1), and Peripheral blood mononuclear cells (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MICAL3 Gene



SOURCE GeneReport for Unigene cluster for MICAL3 Gene Hs.528024

mRNA Expression by UniProt/SwissProt for MICAL3 Gene

Q7RTP6-MICA3_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with MICAL3: view

Protein tissue co-expression partners for MICAL3 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues for MICAL3 Gene

Orthologs for MICAL3 Gene

This gene was present in the common ancestor of animals.

Orthologs for MICAL3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MICAL3 35
  • 83.2 (n)
  • 84.25 (a)
MICAL3 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MICAL3 35
  • 86.74 (n)
  • 88.19 (a)
MICAL3 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mical3 35
  • 84.49 (n)
  • 87.61 (a)
Mical3 16
Mical3 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MICAL3 35
  • 98.58 (n)
  • 98.72 (a)
MICAL3 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mical3 35
  • 84.53 (n)
  • 87.76 (a)
oppossum
(Monodelphis domestica)
Mammalia MICAL3 36
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 55 (a)
OneToMany
-- 36
  • 94 (a)
OneToMany
-- 36
  • 67 (a)
OneToMany
-- 36
  • 55 (a)
OneToMany
-- 36
  • 39 (a)
OneToMany
chicken
(Gallus gallus)
Aves MICAL3 35
  • 72.37 (n)
  • 76.94 (a)
MICAL3 36
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MICAL3 36
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mical3 35
  • 67.39 (n)
  • 69.37 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.14768 35
mical3a 35
  • 66.43 (n)
  • 69.47 (a)
mical3a 36
  • 77 (a)
OneToMany
mical3a 36
  • 57 (a)
OneToMany
mical3b 36
  • 55 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Mical 36
  • 14 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 52 (a)
OneToMany
Species with no ortholog for MICAL3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MICAL3 Gene

ENSEMBL:
Gene Tree for MICAL3 (if available)
TreeFam:
Gene Tree for MICAL3 (if available)

Paralogs for MICAL3 Gene

genes like me logo Genes that share paralogs with MICAL3: view

Variants for MICAL3 Gene

Sequence variations from dbSNP and Humsavar for MICAL3 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs5992128 - 17,872,017(+) CTTCA(G/T)GGAGC nc-transcript-variant, reference, missense
rs11913706 - 17,906,782(+) AGCTG(C/G/T)GTTCA nc-transcript-variant, reference, missense
rs2289719 - 17,885,885(+) GTCTC(C/T)GTATG nc-transcript-variant, reference, missense
rs3384 -- 17,970,803(+) TTTCC(C/T)ATTAT intron-variant
rs7675 -- 17,788,013(+) TTATG(C/T)GTGTG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MICAL3 Gene

Variant ID Type Subtype PubMed ID
nsv526826 CNV Gain 19592680
nsv428385 CNV Gain+Loss 18775914
nsv914151 CNV Gain 21882294
nsv914152 CNV Loss 21882294
nsv834119 CNV Loss 17160897
nsv834120 CNV Loss 17160897
dgv4819n71 CNV Loss 21882294
nsv527393 CNV Loss 19592680
nsv914155 CNV Loss 21882294
esv2493326 CNV Deletion 19546169
esv1920921 CNV Deletion 18987734
esv3910 CNV Deletion 18987735
esv2723954 CNV Deletion 23290073
nsv509806 CNV Insertion 20534489
nsv914157 CNV Gain 21882294
esv2723955 CNV Deletion 23290073
esv2421190 CNV Deletion 18987734
esv993104 CNV Deletion 20482838
nsv914158 CNV Gain 21882294
nsv3555 CNV Insertion 18451855
esv2543355 CNV Deletion 19546169
dgv19e194 CNV Deletion 18987734
dgv774e201 CNV Deletion 23290073
esv27985 CNV Gain+Loss 19812545
esv2723957 CNV Deletion 23290073
esv1410721 CNV Deletion 17803354
dgv816e199 CNV Deletion 23128226
esv2723959 CNV Deletion 23290073
esv1048298 CNV Deletion 17803354
nsv3556 CNV Insertion 18451855
esv275264 CNV Loss 21479260
esv2723960 CNV Deletion 23290073
nsv191257 CNV Loss 16902084
esv2723961 CNV Deletion 23290073
nsv834121 CNV Gain 17160897
nsv914159 CNV Gain 21882294
esv29318 CNV Loss 19812545
nsv914160 CNV Loss 21882294

Variation tolerance for MICAL3 Gene

Residual Variation Intolerance Score: 78.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.11; 84.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MICAL3 Gene

Human Gene Mutation Database (HGMD)
MICAL3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MICAL3 Gene

Disorders for MICAL3 Gene

Relevant External Links for MICAL3

Genetic Association Database (GAD)
MICAL3
Human Genome Epidemiology (HuGE) Navigator
MICAL3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MICAL3

No disorders were found for MICAL3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MICAL3 Gene

Publications for MICAL3 Gene

  1. MICALs, a family of conserved flavoprotein oxidoreductases, function in plexin-mediated axonal repulsion. (PMID: 12110185) Terman J.R. … Kolodkin A.L. (Cell 2002) 2 3 4 67
  2. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert J.P. … Gingras A.C. (J Proteomics 2015) 3
  3. MicroRNA 648 Targets ET-1 mRNA and is cotranscriptionally regulated with MICAL3 by PAX5. (PMID: 25403488) Li C. … Kalra V.K. (Mol. Cell. Biol. 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3

Products for MICAL3 Gene

Sources for MICAL3 Gene

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