Aliases for MICAL3 Gene
External Ids for MICAL3 Gene
GeneCards Summary for MICAL3 Gene
MICAL3 (Microtubule Associated Monooxygenase, Calponin And LIM Domain Containing 3) is a Protein Coding gene. GO annotations related to this gene include actin binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen. An important paralog of this gene is SMTNL2.
UniProtKB/Swiss-Prot for MICAL3 Gene
Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin. Acts by modifying actin subunits through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament severing and prevent repolymerization. Involved in exocytic vesicles tethering and fusion: the monooxygenase activity is required for this process.