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MICAL3 Gene

protein-coding   GIFtS: 50
GCID: GC22M018271

Microtubule Associated Monooxygenase, Calponin And LIM Domain...

  Search for MICAL3
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Microtubule Associated Monooxygenase, Calponin And LIM Domain
Containing 31 2
     Protein MICAL-32
Molecule Interacting With CasL Protein 32 3     Protein-Methionine Sulfoxide Oxidase MICAL32
MICAL-32 3     EC 1.14.13.-3
KIAA13643 5     KIAA08193
Flavoprotein Oxidoreductase MICAL32     

External Ids:    HGNC: 246941   Entrez Gene: 575532   Ensembl: ENSG000002431567   OMIM: 6088825   UniProtKB: Q7RTP63   

Export aliases for MICAL3 gene to outside databases

Previous GC identifers: GC22M016696 GC22M016697 GC22M016691 GC22M016650 GC22M002084


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MICAL3 Gene:
MICAL3 (microtubule associated monooxygenase, calponin and LIM domain containing 3) is a protein-coding gene. GO annotations related to this gene include actin binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen. An important paralog of this gene is MICALL2.

UniProtKB/Swiss-Prot: MICA3_HUMAN, Q7RTP6
Function: Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine
residues on actin. Acts by modifying actin subunits through the addition of oxygen to form methionine-sulfoxide,
leading to promote actin filament severing and prevent repolymerization (By similarity). Involved in exocytic
vesicles tethering and fusion: the monooxygenase activity is required for this process

Gene Wiki entry for MICAL3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000022.11  NT_187355.1  NC_018933.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MICAL3 gene promoter:
         STAT5B   ER-alpha   GATA-3   STAT5A   RORalpha2   GATA-1   GATA-2   RORalpha1   POU2F1   HSF2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for MICAL3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MICAL3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q11.21   Ensembl cytogenetic band:  22q11.21   HGNC cytogenetic band: 22q11.21

MICAL3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MICAL3 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M018271:  view genomic region     (about GC identifiers)

Start:
18,270,415 bp from pter      End:
18,507,325 bp from pter
Size:
236,911 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MICA3_HUMAN, Q7RTP6 (See protein sequence)
Recommended Name: Protein-methionine sulfoxide oxidase MICAL3  
Size: 2002 amino acids; 224295 Da
Cofactor: FAD (By similarity)
Subunit: Interacts with RAB1B. Interacts with ERC1 and RAB8A
1 PDB 3D structure from and Proteopedia for MICAL3:
2D88 (3D)    
Secondary accessions: B2RXJ5 E9PEF0 O94909 Q5U4P4 Q6ICK4 Q96DF2 Q9P2I3
Alternative splicing: 5 isoforms:  Q7RTP6-1   Q7RTP6-2   Q7RTP6-3   Q7RTP6-4   Q7RTP6-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MICAL3: NX_Q7RTP6

Explore proteomics data for MICAL3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MICAL3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001116203.1  NP_001129476.1  NP_056056.2  

    ENSEMBL proteins: 
     ENSP00000416015   ENSP00000463882   ENSP00000462107   ENSP00000462905   ENSP00000464007  
     ENSP00000463453   ENSP00000383406   ENSP00000434678   ENSP00000391827   ENSP00000372574  
     ENSP00000462531   ENSP00000462033   ENSP00000406193   ENSP00000410315   ENSP00000207726  
     ENSP00000414846  

    MICAL3 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
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    Novus Biologicals MICAL3 Proteins
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MICAL3

     
    Search eBioscience for Proteins for MICAL3 

    MICAL3 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of MICAL3
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    Novus Biologicals MICAL3 Antibodies
    Abcam antibodies for MICAL3
    Cloud-Clone Corp. Antibodies for MICAL3
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    Search LSBio for Antibodies for MICAL3

    MICAL3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MICAL3
    Cloud-Clone Corp. CLIAs for MICAL3
    Search eBioscience for ELISAs for MICAL3 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    5 InterPro protein domains:
     IPR003042 Rng_hydrolase-like
     IPR022735 DUF3585
     IPR002938 mOase_FAD-bd
     IPR001715 CH-domain
     IPR001781 Znf_LIM

    Graphical View of Domain Structure for InterPro Entry Q7RTP6

    ProtoNet protein and cluster: Q7RTP6

    3 Blocks protein domains:
    IPB001715 Calponin-like actin-binding
    IPB001781 Zn-binding protein
    IPB002938 Monooxygenase


    UniProtKB/Swiss-Prot: MICA3_HUMAN, Q7RTP6
    Similarity: Belongs to the Mical family
    Similarity: Contains 1 CH (calponin-homology) domain
    Similarity: Contains 1 LIM zinc-binding domain


    Find genes that share domains with MICAL3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MICA3_HUMAN, Q7RTP6
    Function: Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine
    residues on actin. Acts by modifying actin subunits through the addition of oxygen to form methionine-sulfoxide,
    leading to promote actin filament severing and prevent repolymerization (By similarity). Involved in exocytic
    vesicles tethering and fusion: the monooxygenase activity is required for this process
    Catalytic activity: [protein]-methionine + NADPH + O(2) = [protein]-methionine-sulfoxide + NADP(+) + H(2)O

         Enzyme Number (IUBMB): EC 1.14.13.-1

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding ISS--
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
    GO:0016491oxidoreductase activity ----
    GO:0016709oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen ISS--
         
    Find genes that share ontologies with MICAL3           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for MICAL3:
     Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MICAL3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MICAL3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MICAL3
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    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate MICAL3 (see all 98):
    hsa-miR-140-5p hsa-miR-579 hsa-miR-3607-3p hsa-miR-520e hsa-miR-106a hsa-miR-218-1* hsa-miR-128 hsa-miR-30d
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MICAL3
    Predesigned siRNA for gene silencing in human, mouse, rat MICAL3

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for MICAL3

    Clone
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    OriGene clones in human, mouse for MICAL3 (see all 18)
    OriGene ORF clones in mouse, rat for MICAL3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): MICAL3 (NM_015241)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MICAL3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MICAL3

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for MICAL3 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MICAL3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MICA3_HUMAN, Q7RTP6: Cytoplasm. Cytoplasm, cytoskeleton
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol3
    nucleus3
    plasma membrane3
    golgi apparatus1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005856cytoskeleton IEA--

    Find genes that share ontologies with MICAL3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MICAL3
    Interactions:

        Search GeneGlobe Interaction Network for MICAL3

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    3 Interacting proteins for MICAL3 (Q7RTP63 ENSP000004148464) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAP2K5Q131633I2D: score=1 
    RAB1BQ9H0U43I2D: score=1 
    --ensp: ENSP000004160154STRING: ensp: ENSP00000416015
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006887exocytosis IEA--
    GO:0030042actin filament depolymerization ISS--
    GO:0055114oxidation-reduction process ISS--

    Find genes that share ontologies with MICAL3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MICAL3 (MICA3)

    1 HMDB Compound for MICAL3    About this table
    CompoundSynonyms CAS #PubMed Ids
    FAD1H-Purin-6-amine flavin dinucleotide (see all 21)146-14-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MICAL3 gene (4 alternative transcripts): 
    NM_020793.1  NM_001122731.2  NM_001136004.3  NM_015241.2  

    Unigene Cluster for MICAL3:

    Microtubule associated monoxygenase, calponin and LIM domain containing 3
    Hs.528024  [show with all ESTs]
    Unigene Representative Sequence: NM_015241
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 22):
    ENST00000441493(uc010grd.2 uc010gre.2 uc011agl.2 uc002zng.4)
    ENST00000252134 ENST00000580469 ENST00000577821 ENST00000579997 ENST00000584751
    ENST00000498573 ENST00000578984 ENST00000400561 ENST00000495076(uc002znl.1)
    ENST00000578905(uc021wkr.1) ENST00000414725(uc002znj.1 uc002znk.1)
    ENST00000383094 ENST00000461307 ENST00000585038 ENST00000462645 ENST00000465886
    ENST00000498345
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate MICAL3 (see all 98):
    hsa-miR-140-5p hsa-miR-579 hsa-miR-3607-3p hsa-miR-520e hsa-miR-106a hsa-miR-218-1* hsa-miR-128 hsa-miR-30d
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MICAL3
    Predesigned siRNA for gene silencing in human, mouse, rat MICAL3
    Clone
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    OriGene clones in human, mouse for MICAL3 (see all 18)
    OriGene ORF clones in mouse, rat for MICAL3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): MICAL3 (NM_015241)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MICAL3
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat MICAL3
      QuantiTect SYBR Green Assays in human, mouse, rat MICAL3
      QuantiFast Probe-based Assays in human, mouse, rat MICAL3

    Additional mRNA sequence: 

    AB020626.1 AB037785.1 AK023678.1 AK025369.1 AK094822.1 AK124853.1 AK126925.1 AK127487.1 
    AK289506.1 AK295978.1 AL833711.1 BC006562.2 BC035213.1 BC046364.1 BC047315.1 BC064400.1 
    BC085009.1 BC115391.1 BC157876.1 BC171887.1 BX647382.1 CR456364.1 

    Selected DOTS entries (see all 26):

    DT.216356  DT.91679436  DT.75158209  DT.95219234  DT.432528  DT.99944673  DT.95242805  DT.75100235 
    DT.91840877  DT.101983874  DT.102830481  DT.120650071  DT.120650037  DT.446715  DT.92430275  DT.97803489 
    DT.100729427  DT.120650035  DT.120650212  DT.75183110  DT.91738402  DT.95282093  DT.421580  DT.440373 

    Selected AceView cDNA sequences (see all 87):

    BX647382 BX507656 BK000464 BQ947694 BQ215559 F10778 F13172 CR456364 
    Z41052 AI392850 BU158020 AB037785 H55689 AW452613 BU633987 BF055090 
    BU617485 AK094822 BX643501 BX089570 BX488498 BQ340209 AA280960 BU180254 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MICAL3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    MICAL3 Expression
    About this image


    MICAL3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Blood (Hematopoietic System)
             Proerythroblasts Hematopoietic Bone Marrow
     
     Eye (Sensory Organs)
             Retina
    MICAL3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MICAL3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.528024

    UniProtKB/Swiss-Prot: MICA3_HUMAN, Q7RTP6
    Tissue specificity: Ubiquitous

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MICAL3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MICAL3 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mical31 , 5 microtubule associated monoxygenase, calponin and LIM more5
    microtubule associated monooxygenase, calponin and more1
    84.49(n)1
    87.61(a)1
      6 (57.03 cM)5
    1944011  NM_001270475.11  NP_001257404.11 
     1209317075 
    chicken
    (Gallus gallus)
    Aves MICAL31 microtubule associated monoxygenase, calponin and LIM more 72.37(n)
    76.94(a)
      418164  XM_004937953.1  XP_004938010.1 
    lizard
    (Anolis carolinensis)
    Reptilia MICAL36
    microtubule associated monooxygenase, calponin and...
    68(a)
    1 ↔ 1
    5(14090659-14266992)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia mical31 microtubule associated monooxygenase, calponin and more 67.39(n)
    69.37(a)
      100486205  XM_004912491.1  XP_004912548.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.147682 Danio rerio cDNA clone IMAGE4786938, partial cds 78.63(n)    BC059615.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Mical6
    Molecule interacting with CasL
    14(a)
    1 → many
    3R(5827276-5868617)


    ENSEMBL Gene Tree for MICAL3 (if available)
    TreeFam Gene Tree for MICAL3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MICAL3 gene
    MICALL22  MICAL22  EHBP12  SPECC12  SMTNL22  MICALL12  MICALCL2  MICAL12  
    SPECC1L-ADORA2A2  SMTN2  EHBP1L12  SPECC1L2  SMTNL12  
    7 SIMAP similar genes for MICAL3 using alignment to 9 protein entries:     MICA3_HUMAN (see all proteins):
    MICAL2    ACTN1    MICAL1    MICALL1    CRIP1    CRIP2
    LIMD2

    Find genes that share paralogs with MICAL3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MICAL3 (see all 6351)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1920393811,2
    --18269959(+) CTAACA/GAGCAG 1 -- int10--------
    rs1404885061,2
    --18270286(+) AAGCAC/TGAACT 1 -- int10--------
    rs22897141,2
    C,H--18270339(+) AGGCAC/TGAGCT 1 -- int15Minor allele frequency- T:0.00EA NS 1922
    rs1876228841,2
    --18270589(+) TGGCCA/GCCAGG 1 -- ut310--------
    rs76751,2
    C,F,O,A--18270779(+) TTATGC/TGTGTG 1 -- ut3110Minor allele frequency- T:0.18MN NA WA EA 872
    rs1928661381,2
    --18270847(+) GAAAAC/TCTGCC 1 -- ut310--------
    rs801623851,2
    C--18270952(+) GCTTT-/AAAAAA 1 -- ut310--------
    rs1849500751,2
    --18270958(+) AAAAAA/TAGTGC 1 -- ut310--------
    rs1436823631,2
    --18271066(+) CCAGAC/TTGCAG 1 -- ut310--------
    rs10455881,2
    C,F,H--18271078(-) ACACAC/TGGCAG 1 -- ut3112Minor allele frequency- T:0.13MN NA EA NS WA 966

    HapMap Linkage Disequilibrium report for MICAL3 (18270415 - 18507325 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for MICAL3 (see all 38):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv774e201CNV Deletion23290073
    esv2493326CNV Deletion19546169
    esv2723954CNV Deletion23290073
    esv2723961CNV Deletion23290073
    esv2543355CNV Deletion19546169
    dgv19e194CNV Deletion18987734
    esv2723960CNV Deletion23290073
    esv2723959CNV Deletion23290073
    esv993104CNV Deletion20482838
    esv1920921CNV Deletion18987734

    Human Gene Mutation Database (HGMD): MICAL3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MICAL3
    DNA2.0 Custom Variant and Variant Library Synthesis for MICAL3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608882    OMIM disorders: --


    Find genes that share disorders with MICAL3           About GenesLikeMe

    Genetic Association Database (GAD): MICAL3
    Human Genome Epidemiology (HuGE) Navigator: MICAL3 (1 document)

    Export disorders for MICAL3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MICAL3 gene, integrated from 10 sources (see all 30):
    (articles sorted by number of sources associating them with MICAL3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. MICALs, a family of conserved flavoprotein oxidoreductases, function in plexin-mediated axonal repulsion. (PubMed id 12110185)1, 2, 3 Terman J.R.... Kolodkin A.L. (Cell 2002)
    2. Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. (PubMed id 22001757)1, 4 Chambers J.C....Kooner J.S. (Nat. Genet. 2011)
    3. Rab6, Rab8, and MICAL3 cooperate in controlling docking and fusion of exocytotic carriers. (PubMed id 21596566)1, 2 Grigoriev I.... Akhmanova A. (Curr. Biol. 2011)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    6. The MICAL proteins and rab1: a possible link to the cytoskeleton? (PubMed id 15694364)1, 2 Fischer J.... Barnekow A. (Biochem. Biophys. Res. Commun. 2005)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (Genome Biol. 2004)
    9. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2 Nagase T.... Ohara O. (DNA Res. 2000)
    10. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I.... Wright H. (Nature 1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
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      Query String
    PubMed
    OMIM
    NCBI Bookshelf
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 57553 HGNC: 24694 AceView: MICAL3 Ensembl:ENSG00000243156 euGenes: HUgn57553
    ECgene: MICAL3 H-InvDB: MICAL3

    (According to HUGE)
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    HUGE: KIAA1364 KIAA0819

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for MICAL3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MICAL3 gene:
    Search GeneIP for patents involving MICAL3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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