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MICAL2 Gene

protein-coding   GIFtS: 56
GCID: GC11P012115

Microtubule Associated Monooxygenase, Calponin And LIM Domain...

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Microtubule Associated Monooxygenase, Calponin And LIM Domain
Containing 21 2
     KIAA07503 5
Molecule Interacting With CasL Protein 22 3     Flavoprotein Oxidoreductase MICAL22
MICAL-22 3     Microtubule Associated Monoxygenase, Calponin And LIM Domain Containing 22
MICAL2PV12 3     Protein-Methionine Sulfoxide Oxidase MICAL22
MICAL2PV22 3     EC 1.14.13.-3

External Ids:    HGNC: 246931   Entrez Gene: 96452   Ensembl: ENSG000001338167   OMIM: 6088815   UniProtKB: O948513   

Export aliases for MICAL2 gene to outside databases

Previous GC identifers: GC11P012154 GC11P012096 GC11P012088 GC11P011808


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MICAL2 Gene:
MICAL2 (microtubule associated monooxygenase, calponin and LIM domain containing 2) is a protein-coding gene. Diseases associated with MICAL2 include visceral leishmaniasis, and leishmaniasis. GO annotations related to this gene include actin binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen. An important paralog of this gene is MICALL2.

UniProtKB/Swiss-Prot: MICA2_HUMAN, O94851
Function: Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine
residues on actin. Acts by modifying actin subunits through the addition of oxygen to form methionine-sulfoxide,
leading to promote actin filament severing and prevent repolymerization (By similarity)

Gene Wiki entry for MICAL2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NT_009237.19  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MICAL2 gene promoter:
         E2F-3a   E2F-4   E2F-5   E2F-1   E2F   FOXO1a   POU6F1 (c2)   E2F-2   NF-E2   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMICAL2 promoter sequence
   Search Chromatin IP Primers for MICAL2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MICAL2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.3   Ensembl cytogenetic band:  11p15.3   HGNC cytogenetic band: 11p15.3

MICAL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MICAL2 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P012115:  view genomic region     (about GC identifiers)

Start:
12,115,543 bp from pter      End:
12,285,334 bp from pter
Size:
169,792 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: MICA2_HUMAN, O94851 (See protein sequence)
Recommended Name: Protein-methionine sulfoxide oxidase MICAL2  
Size: 1124 amino acids; 126689 Da
Cofactor: FAD (By similarity)
Subunit: Interacts with VIM and PLXNA4 (By similarity). Interacts with RAB1B
Sequence caution: Sequence=BAA34470.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
1 PDB 3D structure from and Proteopedia for MICAL2:
2E9K (3D)    
Secondary accessions: B4DGZ0 B7Z849 D3DQW5 G3XAC8 Q5KTR3 Q5KTR4 Q7Z3A8
Alternative splicing: 6 isoforms:  O94851-1   O94851-2   O94851-3   O94851-4   O94851-5   O94851-6   

Explore the universe of human proteins at neXtProt for MICAL2: NX_O94851

Explore proteomics data for MICAL2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MICAL2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (7 alternative transcripts): 
    NP_001269592.1  NP_001269593.1  NP_001269594.1  NP_001269595.1  NP_001269596.1  NP_001269597.1  NP_055447.1  

    ENSEMBL proteins: 
     ENSP00000434209   ENSP00000435270   ENSP00000256194   ENSP00000434957   ENSP00000433818  
     ENSP00000433965   ENSP00000437229   ENSP00000433509   ENSP00000433357   ENSP00000441689  
     ENSP00000344894   ENSP00000368932  

    MICAL2 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for MICAL2
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    Novus Biologicals MICAL2 Protein
    Novus Biologicals MICAL2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MICAL2

    MICAL2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Abcam antibodies for MICAL2
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    ThermoFisher Antibodies for MICAL2
    LSBio Antibodies in human, mouse, rat for MICAL2

    MICAL2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for MICAL2
    Cloud-Clone Corp. CLIAs for MICAL2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR003042 Rng_hydrolase-like
     IPR002938 mOase_FAD-bd
     IPR001715 CH-domain
     IPR001781 Znf_LIM

    Graphical View of Domain Structure for InterPro Entry O94851

    ProtoNet protein and cluster: O94851

    2 Blocks protein domains:
    IPB001781 Zn-binding protein
    IPB002938 Monooxygenase


    UniProtKB/Swiss-Prot: MICA2_HUMAN, O94851
    Similarity: Belongs to the Mical family
    Similarity: Contains 1 CH (calponin-homology) domain
    Similarity: Contains 1 LIM zinc-binding domain


    MICAL2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MICA2_HUMAN, O94851
    Function: Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine
    residues on actin. Acts by modifying actin subunits through the addition of oxygen to form methionine-sulfoxide,
    leading to promote actin filament severing and prevent repolymerization (By similarity)
    Catalytic activity: [protein]-methionine + NADPH + O(2) = [protein]-methionine-sulfoxide + NADP(+) + H(2)O

         Enzyme Number (IUBMB): EC 1.14.13.-1

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding ISS--
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
    GO:0016491oxidoreductase activity ----
    GO:0016709oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen ISS--
         
    MICAL2 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MICAL2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MICAL2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MICAL2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MICAL2

    miRNA
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    miRTarBase miRNAs that target MICAL2:
    hsa-mir-124-3p (MIRT022138)

    Block miRNA regulation of human, mouse, rat MICAL2 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate MICAL2:
    hsa-miR-9 hsa-miR-19b hsa-miR-340 hsa-miR-3133 hsa-miR-19a
    SwitchGear 3'UTR luciferase reporter plasmidMICAL2 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for MICAL2
    Predesigned siRNA for gene silencing in human, mouse, rat MICAL2

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for MICAL2 (see all 8)
    OriGene ORF clones in mouse, rat for MICAL2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MICAL2 (NM_014632)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MICAL2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MICAL2

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MICAL2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MICA2_HUMAN, O94851: Cytoplasm (By similarity). Cytoplasm, cytoskeleton (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus3
    cytoskeleton2
    golgi apparatus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005856cytoskeleton IEA--

    MICAL2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MICAL2
    Interactions:

        Search GeneGlobe Interaction Network for MICAL2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for MICAL2 (O948513 ENSP000002561944) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PLXNA4Q9HCM23, ENSP000003231944I2D: score=1 STRING: ENSP00000323194
    UBCENSP000003448184STRING: ENSP00000344818
    CAPZA1ENSP000002631684STRING: ENSP00000263168
    CAPZA2ENSP000003549474STRING: ENSP00000354947
    MYO1FENSP000003448714STRING: ENSP00000344871
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0019417sulfur oxidation ISS--
    GO:0030042actin filament depolymerization ISS--
    GO:0055114oxidation-reduction process ISS--

    MICAL2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MICAL2 (MICA2)

    1 HMDB Compound for MICAL2    About this table
    CompoundSynonyms CAS #PubMed Ids
    FAD1H-Purin-6-amine flavin dinucleotide (see all 21)146-14-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MICAL2 gene (7 alternative transcripts): 
    NM_001282663.1  NM_001282664.1  NM_001282665.1  NM_001282666.1  NM_001282667.1  NM_001282668.1  NM_014632.3  

    Unigene Cluster for MICAL2:

    Microtubule associated monoxygenase, calponin and LIM domain containing 2
    Hs.501928  [show with all ESTs]
    Unigene Representative Sequence: BX538021
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 31):
    ENST00000532179 ENST00000526065 ENST00000532945 ENST00000256194(uc001mjz.3 uc001mka.3 uc010rci.2 uc001mkf.3)
    ENST00000531732(uc001mjy.3) ENST00000530823 ENST00000532420 ENST00000527546
    ENST00000524685 ENST00000525119 ENST00000533389 ENST00000528931 ENST00000532166
    ENST00000527195 ENST00000530691(uc001mkb.3 uc001mkc.3 uc001mkd.3 uc010rcj.2)
    ENST00000524730 ENST00000533219 ENST00000529562
    miRNA
    Products:
         
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    5 qRT-PCR Assays for microRNAs that regulate MICAL2:
    hsa-miR-9 hsa-miR-19b hsa-miR-340 hsa-miR-3133 hsa-miR-19a
    SwitchGear 3'UTR luciferase reporter plasmidMICAL2 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for MICAL2
    Predesigned siRNA for gene silencing in human, mouse, rat MICAL2
    Clone
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    OriGene clones in human, mouse for MICAL2 (see all 8)
    OriGene ORF clones in mouse, rat for MICAL2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MICAL2 (NM_014632)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MICAL2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MICAL2
    Primer
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    OriGene qPCR primer pairs and template standards for MICAL2
    OriGene qSTAR qPCR primer pairs in human, mouse for MICAL2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MICAL2
      QuantiTect SYBR Green Assays in human, mouse, rat MICAL2
      QuantiFast Probe-based Assays in human, mouse, rat MICAL2

    Additional mRNA sequence: 

    AB018293.1 AB110785.1 AB110786.1 AF052170.1 AK025186.1 AK026116.1 AK090550.1 AK122821.1 
    AK125552.1 AK125785.1 AK127301.1 AK294845.1 AK302580.1 AK302893.1 AL833719.1 BC015755.1 
    BC017104.1 BC044577.1 BC048206.1 BC063589.1 BX538021.1 BX641163.1 

    24 DOTS entries:

    DT.101984482  DT.95353630  DT.101959775  DT.75103100  DT.91748201  DT.100811170  DT.309925  DT.40290306 
    DT.120720363  DT.95292155  DT.120720337  DT.120720347  DT.120720377  DT.91748200  DT.92027865  DT.95150074 
    DT.95318580  DT.120720315  DT.120720343  DT.40106775  DT.40287910  DT.95134575  DT.95121532  DT.97811942 

    Selected AceView cDNA sequences (see all 301):

    H06880 AA134154 BQ109566 BU527042 AK123090 BQ927198 BM781659 AW069260 
    AA640029 CA391638 AK026116 AK026905 AA482375 AA351596 AB018293 BK000462 
    AK125785 AI079358 BC015755 W52266 AI194083 BX641163 AA058653 AA054706 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MICAL2 (see all 16)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b · 12c ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^
    SP1:              -     -           -     -     -     -                             -     -                       -                                             
    SP2:              -     -           -     -     -     -                             -     -                       -                                             
    SP3:                                                                                -     -                       -                                             
    SP4:                                                                                -     -                       -                                             
    SP5:                                                                                                                                                            

    ExUns: 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22a · 22b ^ 23 ^ 24a · 24b ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32a · 32b · 32c ^ 33 ^ 34a · 34b ^ 35a · 35b · 35c ^
    SP1:              -                       -                                                     -                                         -           -     -   
    SP2:              -                       -                                                     -                                         -           -     -   
    SP3:              -                       -                       -     -     -     -           -     -                                                         
    SP4:              -                       -                       -     -     -     -     -     -     -                                                         
    SP5:              -                       -                       -     -     -     -     -     -     -                                                         


    ECgene alternative splicing isoforms for MICAL2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MICAL2 expression in normal human tissues (normalized intensities)      MICAL2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTGTGACCT
    MICAL2 Expression
    About this image


    MICAL2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Heart (Cardiovascular System)    fully expand to see all 3 entries
             Cushion Mesenchymal Cells Endocardium
             Cardiomyocyte-like progenitor cells
     
     Fibroblasts
             Detroit 551
     
     Epidermis (Integumentary System)
             Detroit 551
     
     Blood (Hematopoietic System)
             Erythroblasts Hematopoietic Bone Marrow
     
     Brain (Nervous System)
             Cerebellum
    MICAL2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MICAL2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.501928
        Custom PCR Arrays for MICAL2
    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat MICAL2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MICAL2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MICAL2 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mical21 , 5 microtubule associated monoxygenase, calponin and LIM more5
    microtubule associated monooxygenase, calponin and more1
    86.47(n)1
    88.19(a)1
      7 (58.74 cM)5
    3208781  NM_001193305.11  NP_001180234.11 
     1122258565 
    chicken
    (Gallus gallus)
    Aves MICAL21 microtubule associated monoxygenase, calponin and LIM more 71.06(n)
    75.77(a)
      423031  XM_003641316.2  XP_003641364.2 
    lizard
    (Anolis carolinensis)
    Reptilia MICAL26
    microtubule associated monooxygenase, calponin and...
    71(a)
    1 ↔ 1
    GL343237.1(683558-776118)
    African clawed frog
    (Xenopus laevis)
    Amphibia BG814923.12   -- 77.49(n)    BG814923.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mical2b1 microtubule associated monoxygenase, calponin and LIM more 68.27(n)
    71.31(a)
      569564  NM_001271913.1  NP_001258842.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Mical6
    Molecule interacting with CasL
    9(a)
    1 → many
    3R(5827276-5868617)


    ENSEMBL Gene Tree for MICAL2 (if available)
    TreeFam Gene Tree for MICAL2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MICAL2 gene
    MICALL22  EHBP12  MICAL32  SPECC12  SMTNL22  MICALL12  MICALCL2  MICAL12  
    SPECC1L-ADORA2A2  SMTN2  EHBP1L12  SPECC1L2  SMTNL12  
    3 SIMAP similar genes for MICAL2 using alignment to 7 protein entries:     MICA2_HUMAN (see all proteins):
    MICAL3    MICAL1    LIMD2

    MICAL2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MICAL2 (see all 3722)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1492625921,2
    C--11806425(+) CAGATA/GTAACA 1 -- us2k10--------
    rs787484891,2
    F--11806566(+) TGGGAG/ATGGGT 1 -- us2k11Minor allele frequency- A:0.01NA 120
    rs1126443531,2
    F--11806580(+) GCCTAG/CAGCAG 1 -- us2k11Minor allele frequency- C:0.50CSA 2
    rs777272091,2
    C,F--11806673(+) CATGTA/GGATTC 1 -- us2k11Minor allele frequency- G:0.03EA 120
    rs1883278121,2
    --11806706(+) CCGGAC/TTCTGA 1 -- us2k10--------
    rs1396417431,2
    C--11806789(+) ATGATA/GATACA 1 -- us2k10--------
    rs1436762161,2
    --11807207(+) ATACTC/GTTTCT 1 -- us2k10--------
    rs1472164241,2
    --11807399(+) GGTGTC/TTTACA 1 -- us2k10--------
    rs1926703591,2
    --11807439(+) TGCTCA/GCTAGG 1 -- us2k10--------
    rs1847247821,2
    --11807496(+) GCTGTA/GGGGGG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for MICAL2 (12115543 - 12285334 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for MICAL2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2252219CNV Deletion18987734
    esv2744115CNV Deletion23290073
    esv2744116CNV Deletion23290073
    esv4083CNV Deletion18987735
    esv2664585CNV Deletion23128226
    nsv467708CNV Loss19166990
    esv5666CNV Loss19470904
    nsv515573CNV Loss19592680
    nsv832068CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MICAL2
    DNA2.0 Custom Variant and Variant Library Synthesis for MICAL2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608881    OMIM disorders: --

    5 diseases for MICAL2:    About MalaCards
    visceral leishmaniasis    leishmaniasis    prostate cancer    prostatitis
    malaria

    1 disease from the University of Copenhagen DISEASES database for MICAL2:
    Visceral leishmaniasis

    MICAL2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): MICAL2
    Human Genome Epidemiology (HuGE) Navigator: MICAL2 (1 document)

    Export disorders for MICAL2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MICAL2 gene, integrated from 10 sources (see all 18):
    (articles sorted by number of sources associating them with MICAL2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. MICALs, a family of conserved flavoprotein oxidoreductases, function in plexin-mediated axonal repulsion. (PubMed id 12110185)1, 2, 3 Terman J.R.... Kolodkin A.L. (Cell 2002)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Expression of novel molecules, MICAL2-PV (MICAL2 prostate cancer variants), increases with high Gleason score and prostate cancer progression. (PubMed id 16675569)1, 2 Ashida S.... Nakagawa H. (Clin. Cancer Res. 2006)
    4. The MICAL proteins and rab1: a possible link to the cytoskeleton? (PubMed id 15694364)1, 2 Fischer J.... Barnekow A. (Biochem. Biophys. Res. Commun. 2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9872452)1, 2 Nagase T.... Ohara O. (DNA Res. 1998)
    8. Generalization of Variants Identified by Genome-Wide Association Studies for Electrocardiographic Traits in African Americans. (PubMed id 23534349)1 Jeff J.M....Crawford D.C. (Ann. Hum. Genet. 2013)
    9. Differential regulation of actin microfilaments by human MICAL proteins. (PubMed id 22331357)1 Giridharan S.S....Caplan S. (J. Cell. Sci. 2012)
    10. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9645 HGNC: 24693 AceView: MICAL2 Ensembl:ENSG00000133816 euGenes: HUgn9645
    ECgene: MICAL2 H-InvDB: MICAL2

    (According to HUGE)
    About This Section

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    HUGE: KIAA0750

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MICAL2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MICAL2 gene:
    Search GeneIP for patents involving MICAL2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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