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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

MICAL2 Gene

protein-coding GIFtS: 54
GCID: GC11P012115

microtubule associated monoxygenase, calponin and LIM domain...

Explore 5 diseases affiliated with
MICAL2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Microtubule Associated Monoxygenase, Calponin And LIM Domain Containing 2¹ ²		MICAL2PV2² ³
KIAA0750¹ ³ ⁵		Flavoprotein Oxidoreductase MICAL2²
Molecule Interacting With CasL Protein 2² ³		Protein MICAL-2²
MICAL-2² ³		Protein-Methionine Sulfoxide Oxidase MICAL2²
MICAL2PV1² ³		EC 1.14.13.-³

External Ids:	HGNC: 24693¹	Entrez Gene: 9645²	Ensembl: ENSG00000133816⁷	OMIM: 608881⁵	UniProtKB: O94851³

Export aliases for MICAL2 gene to outside databases

Previous GC identifers: GC11P012154 GC11P012096 GC11P012088 GC11P011808

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: MICA2_HUMAN, O94851

Function: Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine

residues on actin. Acts by modifying actin subunits through the addition of oxygen to form methionine-sulfoxide,

leading to promote actin filament severing and prevent repolymerization (By similarity)

Gene Wiki entry for MICAL2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_009237.18

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the MICAL2 gene promoter:
E2F-3a E2F-4 E2F-5 E2F-1 E2F FOXO1a POU6F1 (c2) E2F-2 NF-E2 FOXO1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MICAL2 promoter sequence

Search SABiosciences Chromatin IP Primers for MICAL2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MICAL2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.3 Ensembl cytogenetic band: 11p15.3 HGNC cytogenetic band: 11p15.3

MICAL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MICAL2 gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11P012115: view genomic region (about GC identifiers)

Start:	12,115,543 bp from pter	End:	12,285,334 bp from pter
Size:	169,792 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MICA2_HUMAN, O94851 (See protein sequence)

Recommended Name: Protein-methionine sulfoxide oxidase MICAL2

Size: 1124 amino acids; 126689 Da

Cofactor: FAD (By similarity)

Subunit: Interacts with VIM and PLXNA4 (By similarity). Interacts with RAB1B

Subcellular location: Cytoplasm (By similarity). Cytoplasm, cytoskeleton (By similarity)

Sequence caution: Sequence=BAA34470.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;

1 PDB 3D structure from and Proteopedia for MICAL2:

2E9K (3D)

Secondary accessions: B4DGZ0 B7Z849 D3DQW5 G3XAC8 Q5KTR3 Q5KTR4 Q7Z3A8

Alternative splicing: 6 isoforms: O94851-1 O94851-2 O94851-3 O94851-4 O94851-5 O94851-6

Explore the universe of human proteins at neXtProt for MICAL2: NX_O94851

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O94851

MICAL2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_055447.1

ENSEMBL proteins:

ENSP00000434209 ENSP00000435270 ENSP00000256194 ENSP00000434957 ENSP00000433818

ENSP00000433965 ENSP00000437229 ENSP00000433509 ENSP00000433357 ENSP00000441689

ENSP00000344894 ENSP00000368932

Human Recombinant Protein Products:

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	Novus Biologicals MICAL2 Protein Novus Biologicals MICAL2 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for MICAL2

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--
GO:0005856	cytoskeleton	IEA	--

MICAL2 for ontologies About GeneDecksing

MICAL2 Antibody Products:

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	Uscn ELISAs and CLIAs for MICAL2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

MICAL2 for domains About GeneDecksing

4 InterPro domains/families:

IPR003042 Rng_hydrolase-like

IPR002938 mOase_FAD-bd

IPR001715 CH-domain

IPR001781 Znf_LIM

Graphical View of Domain Structure for InterPro Entry O94851

ProtoNet protein and cluster: O94851

2 Blocks protein families:

IPB001781 Zn-binding protein

IPB002938 Monooxygenase

UniProtKB/Swiss-Prot: MICA2_HUMAN, O94851

Similarity: Belongs to the Mical family

Similarity: Contains 1 CH (calponin-homology) domain

Similarity: Contains 1 LIM zinc-binding domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: MICA2_HUMAN, O94851

Function: Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine

residues on actin. Acts by modifying actin subunits through the addition of oxygen to form methionine-sulfoxide,

leading to promote actin filament severing and prevent repolymerization (By similarity)

Catalytic activity: [protein]-methionine + NADPH + O(2) = [protein]-methionine-sulfoxide + NADP(+) + H(2)O

Enzyme Number (IUBMB): EC 1.14.13.-¹

miRNA Products:		OriGene 3'-UTR Clone: MICAL2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MICAL2
		5 QIAGEN miScript miRNA Assays for microRNAs that regulate MICAL2:
		hsa-miR-9 hsa-miR-19b hsa-miR-340 hsa-miR-3133 hsa-miR-19a
		SwitchGear 3'UTR luciferase reporter plasmid: MICAL2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MICAL2 (see all 7) OriGene shRNA RFP: MICAL2 OriGene siRNA: MICAL2
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Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for MICAL2

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		Search LifeMap BioReagents cell lines for MICAL2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MICAL2

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003779	actin binding	ISS	--
GO:0008270	zinc ion binding	IEA	--
GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	ISS	--
GO:0071949	FAD binding	ISS	--

MICAL2 for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for MICAL2

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

2 Interacting proteins for MICAL2 (O94851³ ENSP00000256194⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PLXNA4	Q9HCM2³, ENSP00000323194⁴	I2D: score=1 STRING: ENSP00000323194
UBC	ENSP00000344818⁴	STRING: ENSP00000344818

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0030042	actin filament depolymerization	ISS	--
GO:0055114	oxidation-reduction process	ISS	--

MICAL2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for MICAL2

1 HMDB Compound for MICAL2 About this table

Compound	Synonyms	CAS #	PubMed Ids
FAD	1H-Purin-6-amine flavin dinucleotide (see all 21)	146-14-5	--

Search CenterWatch for drugs/clinical trials and news about MICAL2 / MICA2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MICAL2 gene:

NM_014632.2

Unigene Cluster for MICAL2:

Microtubule associated monoxygenase, calponin and LIM domain containing 2

Hs.501928 [show with all ESTs]

Unigene Representative Sequence: BX538021

18/31 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 31):

ENST00000532179 ENST00000526065 ENST00000532945 ENST00000256194(uc001mjz.3 uc001mka.3 uc010rci.2 uc001mkf.3)

ENST00000531732(uc001mjy.3) ENST00000530823 ENST00000532420 ENST00000527546

ENST00000524685 ENST00000525119 ENST00000533389 ENST00000528931 ENST00000532166

ENST00000527195 ENST00000530691(uc001mkb.3 uc001mkc.3 uc001mkd.3 uc010rcj.2)

ENST00000524730 ENST00000533219 ENST00000529562

miRNA Products:		OriGene 3'-UTR Clone: MICAL2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MICAL2
		5 QIAGEN miScript miRNA Assays for microRNAs that regulate MICAL2:
		hsa-miR-9 hsa-miR-19b hsa-miR-340 hsa-miR-3133 hsa-miR-19a
		SwitchGear 3'UTR luciferase reporter plasmid: MICAL2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MICAL2 (see all 7) OriGene shRNA RFP: MICAL2 OriGene siRNA: MICAL2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MICAL2

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MICAL2 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MICAL2 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: MICAL2 (NM_014632)
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MICAL2

Additional cDNA sequence:

AB018293.1 AB110785.1 AB110786.1 AF052170.1 AK025186.1 AK026116.1 AK090550.1 AK122821.1

AK125552.1 AK125785.1 AK127301.1 AK294845.1 AK302580.1 AK302893.1 AL833719.1 BC015755.1

BC017104.1 BC044577.1 BC048206.1 BC063589.1 BX538021.1 BX641163.1

24 DOTS entries:

DT.101984482 DT.95353630 DT.101959775 DT.75103100 DT.91748201 DT.100811170 DT.309925 DT.40290306

DT.120720363 DT.95292155 DT.120720337 DT.120720347 DT.120720377 DT.91748200 DT.92027865 DT.95150074

DT.95318580 DT.120720315 DT.120720343 DT.40106775 DT.40287910 DT.95134575 DT.95121532 DT.97811942

24/301 AceView cDNA sequences (see all 301):

CR616756 T08701 BI755400 CF272409 AA417885 AA701881 H06880 W52266

BC015755 BX489847 AA054706 BX641163 BQ927198 AA058653 AK123090 BM781659

AA134154 BU527042 BQ109566 AA640029 AW069260 AA482375 AK026116 CA391638

GeneLoc Exon Structure

5/16 Alternative Splicing Database (ASD) splice patterns (SP) for MICAL2 (see all 16) About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5	^	6	^	7a	·	7b	^	8a	·	8b	·	8c	·	8d	^	9	^	10	^	11a	·	11b	·	11c	^	12a	·	12b	·	12c	^	13	^	14	^	15	^	16	^	17	^
SP1:					-		-				-		-		-		-										-		-								-
SP2:					-		-				-		-		-		-										-		-								-
SP3:																											-		-								-
SP4:																											-		-								-
SP5:

ExUns:	18	^	19	^	20a	·	20b	^	21	^	22a	·	22b	^	23	^	24a	·	24b	^	25	^	26	^	27	^	28	^	29	^	30	^	31	^	32a	·	32b	·	32c	^	33	^	34a	·	34b	^	35a	·	35b	·	35c	^
SP1:					-								-																		-														-				-		-
SP2:					-								-																		-														-				-		-
SP3:					-								-								-		-		-		-				-		-
SP4:					-								-								-		-		-		-		-		-		-
SP5:					-								-								-		-		-		-		-		-		-

ECgene alternative splicing isoforms for MICAL2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MICAL2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCTGTGACCT

About this image

MICAL2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Heart

Endocardium

Cushion Mesenchymal Cells

Endocardium

Heart

Endocardium

Endocardial Tube Cells

Endocardium

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Posterior foregut-like cells (A scalable, suspensi...)

See MICAL2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MICAL2

SOURCE GeneReport for Unigene cluster: Hs.501928

SABiosciences Custom PCR Arrays for MICAL2

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MICAL2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MICAL2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for MICAL2 gene from 5/21 species (see all 21) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	MICAL2¹	microtubule associated monoxygenase, calponin and LIM more	71.3(n) 76.37(a)		423031 XM_003641316.1 XP_003641364.1
lizard (Anolis carolinensis)	Reptilia	MICAL2⁶	--	73(a)	1 → many	GL343237.1(683652-758101)
African clawed frog (Xenopus laevis)	Amphibia	BG814923.1²	--	77.49(n)		BG814923.1
zebrafish (Danio rerio)	Actinopterygii	mical2a¹	microtubule associated monoxygenase, calponin and LIM more	65.22(n) 66.09(a)		569607 XM_001919062.3 XP_001919097.3
fruit fly (Drosophila melanogaster)	Insecta	Mical⁶	Molecule interacting with CasL	7(a)	1 → many	3R(5827276-5868617)

ENSEMBL Gene Tree for MICAL2 (if available)
TreeFam Gene Tree for MICAL2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for MICAL2 gene

MICALL2² MICALL1² MICALCL² MICAL1² EHBP1² MICAL3² EHBP1L1²

3 SIMAP similar genes for MICAL2 using alignment to 7 protein entries: MICA2_HUMAN (see all proteins):

MICAL3 MICAL1 LIMD2

MICAL2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs35041002^1,2	C,	--	12137691(+)	`GCTAA-/TTTTTT`	1	--	int¹		2		NA CSA	4
rs11307651^1,2	C,F,	--	12147417(+)	`TTCAG-/TTTTTT`	1	--	int¹ trp³		3		NA CSA	6
rs200443025^1,2		--	12151168(+)	`TCTGT-/TTCTTCTT`	1	--	int¹		0	--	--	--	--
rs71313463^1,2	C	--	12166689(-)	`GCTAC-/AATGAA`	1	--	int¹		1		NA	2
rs67392690^1,2	C	--	12170382(+)	`AATTA-/ATGCTT`	1	--	int¹		0	--	--	--	--
rs67465822^1,2	C,	--	12190512(+)	`AAAAG-/AAAA GAAAA`	1	--	int¹		0	--	--	--	--
rs67030410^1,2	C	--	12190515(+)	`AGAAAG/AGAAAA`	1	--	int¹		1		WA	2
rs72129077^1,2	C,	--	12213333(+)	`AAAAA-/AGAGAGA`	1	--	int¹		0	--	--	--	--
rs7945454^1,2	C,	--	12213334(+)	`AAAAAG/AAGAGA`	1	--	int¹ trp³		1		CSA	2
rs10584334^1,2	C	--	12213334(+)	`AGAGA-/GATGTTG`	1	--	int¹ trp³		1		NA	2

HapMap Linkage Disequilibrium report for MICAL2 (12115543 - 12285334 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for MICAL2
1 CNV: 48711
2 Indels: 42984 61102

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MICAL2

DNA2.0 Custom Variant and Variant Library Synthesis for MICAL2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

MICAL2 for disorders           About GeneDecksing

OMIM gene information: 608881    OMIM disorders: --

5 diseases for MICAL2:    About MalaCards

visceral leishmaniasis leishmaniasis prostate cancer, progression of prostate cancer

prostatitis

1 disease from the University of Copenhagen DISEASES database for MICAL2:

Visceral leishmaniasis

Human Genome Epidemiology (HuGE) Navigator: MICAL2 (1 document)

Export disorders for MICAL2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for MICAL2 gene, integrated from 9 sources (see all 15):
(articles sorted by number of sources associating them with MICAL2)

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MICALs, a family of conserved flavoprotein oxidoreductases, function in plexin-mediated axonal repulsion. (PubMed id 12110185)^{1, 2, 3} Terman J.R.... Kolodkin A.L. (2002)
Expression of novel molecules, MICAL2-PV (MICAL2 prostate cancer variants), increases with high Gleason score and prostate cancer progression. (PubMed id 16675569)^{1, 2} Ashida S....Nakagawa H. (2006)
The MICAL proteins and rab1: a possible link to the cytoskeleton? (PubMed id 15694364)^{1, 2} Fischer J.... Barnekow A. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9872452)^{1, 2} Nagase T.... Ohara O. (1998)
Differential regulation of actin microfilaments by hum an MICAL proteins. (PubMed id 22331357)¹ Giridharan S.S....Caplan S. (2012)
Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)
Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (2011)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 9645	HGNC: 24693	AceView: MICAL2	Ensembl:ENSG00000133816	euGenes: HUgn9645
ECgene: MICAL2	H-InvDB: MICAL2

(According to HUGE)
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HUGE: KIAA0750

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for MICAL2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for MICAL2 gene
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Patent Information for MICAL2 gene:
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