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Aliases for MICAL2 Gene

Aliases for MICAL2 Gene

  • Microtubule Associated Monooxygenase, Calponin And LIM Domain Containing 2 2 3
  • Molecule Interacting With CasL Protein 2 3 4
  • MICAL2PV1 3 4
  • MICAL2PV2 3 4
  • KIAA0750 4 6
  • MICAL-2 3 4
  • Microtubule Associated Monoxygenase, Calponin And LIM Domain Containing 2 3
  • Protein-Methionine Sulfoxide Oxidase MICAL2 3
  • Flavoprotein Oxidoreductase MICAL2 3
  • EC 1.14.13.- 4

External Ids for MICAL2 Gene

Summaries for MICAL2 Gene

GeneCards Summary for MICAL2 Gene

MICAL2 (Microtubule Associated Monooxygenase, Calponin And LIM Domain Containing 2) is a Protein Coding gene. GO annotations related to this gene include actin binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen. An important paralog of this gene is SMTNL2.

UniProtKB/Swiss-Prot for MICAL2 Gene

  • Nuclear monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin and regulates the SRF signaling. Acts by modifying nuclear actin subunits through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament severing and prevent repolymerization. Acts as a key regulator of the SRF signaling pathway elicited by nerve growth factor and serum: mediates oxidation and subsequent depolymerization of nuclear actin, leading to increase MKL1/MRTF-A presence in the nucleus and promote SRF:MKL1/MRTF-A-dependent gene transcription. Does not activate SRF:MKL1/MRTF-A through RhoA.

Gene Wiki entry for MICAL2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MICAL2 Gene

Genomics for MICAL2 Gene

Genomic Location for MICAL2 Gene

Start:
12,094,008 bp from pter
End:
12,263,790 bp from pter
Size:
169,783 bases
Orientation:
Plus strand

Genomic View for MICAL2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MICAL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MICAL2 Gene

Regulatory Elements for MICAL2 Gene

Proteins for MICAL2 Gene

  • Protein details for MICAL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94851-MICA2_HUMAN
    Recommended name:
    Protein-methionine sulfoxide oxidase MICAL2
    Protein Accession:
    O94851
    Secondary Accessions:
    • B4DGZ0
    • B7Z849
    • D3DQW5
    • G3XAC8
    • Q5KTR3
    • Q5KTR4
    • Q7Z3A8

    Protein attributes for MICAL2 Gene

    Size:
    1124 amino acids
    Molecular mass:
    126689 Da
    Cofactor:
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Quaternary structure:
    • Interacts with VIM and PLXNA4 (By similarity). Interacts with RAB1B.
    SequenceCaution:
    • Sequence=BAA34470.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MICAL2 Gene

    Alternative splice isoforms for MICAL2 Gene

neXtProt entry for MICAL2 Gene

Proteomics data for MICAL2 Gene at MOPED

Post-translational modifications for MICAL2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MICAL2 Gene

Domains for MICAL2 Gene

UniProtKB/Swiss-Prot:

MICA2_HUMAN
Domain:
  • Contains 1 CH (calponin-homology) domain.:
    • O94851
  • Contains 1 LIM zinc-binding domain.:
    • O94851
Family:
  • Belongs to the Mical family.:
    • O94851
genes like me logo Genes that share domains with MICAL2: view

No data available for Gene Families for MICAL2 Gene

Function for MICAL2 Gene

Molecular function for MICAL2 Gene

UniProtKB/Swiss-Prot CatalyticActivity: [protein]-methionine + NADPH + O(2) = [protein]-methionine-sulfoxide + NADP(+) + H(2)O.
UniProtKB/Swiss-Prot EnzymeRegulation: Specifically inhibited by CCG-1423, a small molecule inhibitor of SRF:MKL1/MRTF-A-dependent transcription.
UniProtKB/Swiss-Prot Function: Nuclear monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin and regulates the SRF signaling. Acts by modifying nuclear actin subunits through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament severing and prevent repolymerization. Acts as a key regulator of the SRF signaling pathway elicited by nerve growth factor and serum: mediates oxidation and subsequent depolymerization of nuclear actin, leading to increase MKL1/MRTF-A presence in the nucleus and promote SRF:MKL1/MRTF-A-dependent gene transcription. Does not activate SRF:MKL1/MRTF-A through RhoA.

Enzyme Numbers (IUBMB) for MICAL2 Gene

Gene Ontology (GO) - Molecular Function for MICAL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding ISS --
GO:0005515 protein binding --
GO:0008270 zinc ion binding IEA --
GO:0016491 oxidoreductase activity --
GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen ISS --
genes like me logo Genes that share ontologies with MICAL2: view

miRNA for MICAL2 Gene

miRTarBase miRNAs that target MICAL2

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for MICAL2 Gene

Localization for MICAL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MICAL2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MICAL2 Gene COMPARTMENTS Subcellular localization image for MICAL2 gene
Compartment Confidence
cytosol 3
nucleus 3
cytoskeleton 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for MICAL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 24440334
genes like me logo Genes that share ontologies with MICAL2: view

Pathways for MICAL2 Gene

SuperPathways for MICAL2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MICAL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001947 heart looping ISS --
GO:0007010 cytoskeleton organization IDA 24440334
GO:0007507 heart development ISS --
GO:0010735 positive regulation of transcription via serum response element binding IMP 24440334
GO:0019417 sulfur oxidation ISS --
genes like me logo Genes that share ontologies with MICAL2: view

No data available for Pathways by source for MICAL2 Gene

Compounds for MICAL2 Gene

(1) HMDB Compounds for MICAL2 Gene

Compound Synonyms Cas Number PubMed IDs
FAD
  • 1H-Purin-6-amine flavin dinucleotide
146-14-5
genes like me logo Genes that share compounds with MICAL2: view

Transcripts for MICAL2 Gene

Unigene Clusters for MICAL2 Gene

Microtubule associated monoxygenase, calponin and LIM domain containing 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MICAL2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b · 12c ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^
SP1: - - - - - - - - -
SP2: - - - - - - - - -
SP3: - - -
SP4: - - -
SP5:
SP6:
SP7:
SP8: - - - -
SP9:
SP10:
SP11: - -
SP12: - - -
SP13: - -
SP14: - - - - -
SP15: - -
SP16:

ExUns: 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22a · 22b ^ 23 ^ 24a · 24b ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32a · 32b · 32c ^ 33 ^ 34a · 34b ^ 35a · 35b · 35c ^
SP1: - - - - - -
SP2: - - - - - -
SP3: - - - - - - - -
SP4: - - - - - - - - -
SP5: - - - - - - - - -
SP6: - - - -
SP7: -
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

Relevant External Links for MICAL2 Gene

GeneLoc Exon Structure for
MICAL2
ECgene alternative splicing isoforms for
MICAL2

Expression for MICAL2 Gene

mRNA expression in normal human tissues for MICAL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MICAL2 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (8.0) and Brain - Cerebellum (7.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MICAL2 Gene

SOURCE GeneReport for Unigene cluster for MICAL2 Gene Hs.501928

genes like me logo Genes that share expressions with MICAL2: view

Orthologs for MICAL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for MICAL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MICAL2 36
  • 99.29 (n)
  • 99.2 (a)
MICAL2 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MICAL2 36
  • 89.54 (n)
  • 90.46 (a)
MICAL2 37
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MICAL2 36
  • 90.46 (n)
  • 92.35 (a)
MICAL2 37
  • 52 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mical2 36
  • 86.47 (n)
  • 88.19 (a)
Mical2 16
Mical2 37
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MICAL2 37
  • 46 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MICAL2 37
  • 77 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mical2 36
  • 85.62 (n)
  • 87.77 (a)
chicken
(Gallus gallus)
Aves MICAL2 36
  • 71.06 (n)
  • 75.77 (a)
MICAL2 37
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MICAL2 37
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100487018 36
  • 66.94 (n)
  • 68.22 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6941 36
zebrafish
(Danio rerio)
Actinopterygii MICAL2 (3 of 3) 37
  • 63 (a)
OneToMany
mical2a 37
  • 62 (a)
OneToMany
mical2b 36
  • 68.27 (n)
  • 71.31 (a)
mical2b 37
  • 39 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Mical 37
  • 9 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1958 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 49 (a)
OneToMany
Species with no ortholog for MICAL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MICAL2 Gene

ENSEMBL:
Gene Tree for MICAL2 (if available)
TreeFam:
Gene Tree for MICAL2 (if available)

Paralogs for MICAL2 Gene

Selected SIMAP similar genes for MICAL2 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with MICAL2: view

Variants for MICAL2 Gene

Sequence variations from dbSNP and Humsavar for MICAL2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs8808 -- 12,263,543(+) CTTGT(C/T)TTATC intron-variant, utr-variant-3-prime
rs368175 -- 12,127,267(-) CCATA(G/T)AGCAA intron-variant
rs368946 -- 12,125,788(-) CCTGT(C/G)CCCAT intron-variant
rs371640 -- 12,128,081(-) CCCTA(A/T)CACAT intron-variant
rs377059 -- 12,128,226(-) GGTGG(G/T)AACAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MICAL2 Gene

Variant ID Type Subtype PubMed ID
nsv832068 CNV Gain 17160897
esv4083 CNV Deletion 18987735
esv2744115 CNV Deletion 23290073
esv5666 CNV Loss 19470904
esv2664585 CNV Deletion 23128226
nsv515573 CNV Loss 19592680
nsv467708 CNV Loss 19166990
esv2252219 CNV Deletion 18987734
esv2744116 CNV Deletion 23290073

Relevant External Links for MICAL2 Gene

HapMap Linkage Disequilibrium report
MICAL2

Disorders for MICAL2 Gene

(1) University of Copenhagen DISEASES for MICAL2 Gene

Relevant External Links for MICAL2

Genetic Association Database (GAD)
MICAL2
Human Genome Epidemiology (HuGE) Navigator
MICAL2
genes like me logo Genes that share disorders with MICAL2: view

No data available for UniProtKB/Swiss-Prot for MICAL2 Gene

Publications for MICAL2 Gene

  1. MICALs, a family of conserved flavoprotein oxidoreductases, function in plexin-mediated axonal repulsion. (PMID: 12110185) Terman J.R. … Kolodkin A.L. (Cell 2002) 2 3 4
  2. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9872452) Nagase T. … Ohara O. (DNA Res. 1998) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. The MICAL proteins and rab1: a possible link to the cytoskeleton? (PMID: 15694364) Fischer J. … Barnekow A. (Biochem. Biophys. Res. Commun. 2005) 3 4

Products for MICAL2 Gene

Sources for MICAL2 Gene

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