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Aliases for MICAL2 Gene

Aliases for MICAL2 Gene

  • Microtubule Associated Monooxygenase, Calponin And LIM Domain Containing 2 2 3 5
  • Molecule Interacting With CasL Protein 2 3 4
  • MICAL2PV1 3 4
  • MICAL2PV2 3 4
  • MICAL-2 3 4
  • Microtubule Associated Monoxygenase, Calponin And LIM Domain Containing 2 3
  • Protein-Methionine Sulfoxide Oxidase MICAL2 3
  • Flavoprotein Oxidoreductase MICAL2 3
  • EC 1.14.13.- 4
  • KIAA0750 4

External Ids for MICAL2 Gene

Previous GeneCards Identifiers for MICAL2 Gene

  • GC11P012154
  • GC11P012096
  • GC11P012088
  • GC11P011808

Summaries for MICAL2 Gene

Entrez Gene Summary for MICAL2 Gene

  • The protein encoded by this gene is a monooxygenase that enhances depolymerization of F-actin and is therefore involved in cytoskeletal dynamics. The encoded protein is a regulator of the SRF signaling pathway. Increased expression of this gene has been associated with cancer progression and metastasis. [provided by RefSeq, Oct 2016]

GeneCards Summary for MICAL2 Gene

MICAL2 (Microtubule Associated Monooxygenase, Calponin And LIM Domain Containing 2) is a Protein Coding gene. GO annotations related to this gene include actin binding and flavin adenine dinucleotide binding. An important paralog of this gene is MICAL3.

UniProtKB/Swiss-Prot for MICAL2 Gene

  • Nuclear monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin and regulates the SRF signaling. Acts by modifying nuclear actin subunits through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament severing and prevent repolymerization. Acts as a key regulator of the SRF signaling pathway elicited by nerve growth factor and serum: mediates oxidation and subsequent depolymerization of nuclear actin, leading to increase MKL1/MRTF-A presence in the nucleus and promote SRF:MKL1/MRTF-A-dependent gene transcription. Does not activate SRF:MKL1/MRTF-A through RhoA.

Gene Wiki entry for MICAL2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MICAL2 Gene

Genomics for MICAL2 Gene

Regulatory Elements for MICAL2 Gene

Enhancers for MICAL2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F012155 1.5 VISTA FANTOM5 Ensembl ENCODE 18.1 +79.5 79461 35.4 HDGF PKNOX1 ARNT CREB3L1 SIN3A FEZF1 ZNF766 FOS KLF13 DEK MICAL2 MICALCL MIR6124 GC11P012216
GH11F012283 1.5 FANTOM5 Ensembl ENCODE 14.9 +192.7 192683 5.7 ZFP64 SIN3A RAD21 ZNF143 RCOR1 FOS DEK EGR2 ZNF263 ZNF654 MICAL2 ENSG00000254680 PARVA MICALCL TEAD1 DKK3 ENSG00000254983
GH11F012048 1.1 Ensembl ENCODE 14.4 -44.8 -44813 1.4 GATA3 CEBPB DKK3 MICAL2 ENSG00000254991 LOC105376554
GH11F012050 0.5 Ensembl ENCODE 13.6 -42.7 -42747 1.3 ATF3 HNF4G ZBTB33 ZIC2 RAD21 NR2F2 YY1 DKK3 MICAL2 ENSG00000254991 LOC105376554
GH11F012194 1.7 FANTOM5 Ensembl ENCODE 12.6 +104.8 104806 8.0 PKNOX1 ARNT CREB3L1 SIN3A YY1 FOS KLF13 SP5 REST MEF2D MICAL2 MICALCL PARVA GC11P012216 MIR6124
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MICAL2 on UCSC Golden Path with GeneCards custom track

Genomic Location for MICAL2 Gene

Chromosome:
11
Start:
12,094,008 bp from pter
End:
12,281,016 bp from pter
Size:
187,009 bases
Orientation:
Plus strand

Genomic View for MICAL2 Gene

Genes around MICAL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MICAL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MICAL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MICAL2 Gene

Proteins for MICAL2 Gene

  • Protein details for MICAL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94851-MICA2_HUMAN
    Recommended name:
    Protein-methionine sulfoxide oxidase MICAL2
    Protein Accession:
    O94851
    Secondary Accessions:
    • B4DGZ0
    • B7Z849
    • D3DQW5
    • G3XAC8
    • Q5KTR3
    • Q5KTR4
    • Q7Z3A8

    Protein attributes for MICAL2 Gene

    Size:
    1124 amino acids
    Molecular mass:
    126689 Da
    Cofactor:
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Quaternary structure:
    • Interacts with VIM and PLXNA4 (By similarity). Interacts with RAB1B.
    SequenceCaution:
    • Sequence=BAA34470.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MICAL2 Gene

    Alternative splice isoforms for MICAL2 Gene

neXtProt entry for MICAL2 Gene

Post-translational modifications for MICAL2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MICAL2 Gene

Domains & Families for MICAL2 Gene

Gene Families for MICAL2 Gene

Suggested Antigen Peptide Sequences for MICAL2 Gene

Graphical View of Domain Structure for InterPro Entry

O94851

UniProtKB/Swiss-Prot:

MICA2_HUMAN :
  • Contains 1 CH (calponin-homology) domain.
  • Belongs to the Mical family.
Domain:
  • Contains 1 CH (calponin-homology) domain.
  • Contains 1 LIM zinc-binding domain.
Family:
  • Belongs to the Mical family.
genes like me logo Genes that share domains with MICAL2: view

Function for MICAL2 Gene

Molecular function for MICAL2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
[protein]-methionine + NADPH + O(2) = [protein]-methionine-sulfoxide + NADP(+) + H(2)O.
UniProtKB/Swiss-Prot EnzymeRegulation:
Specifically inhibited by CCG-1423, a small molecule inhibitor of SRF:MKL1/MRTF-A-dependent transcription.
UniProtKB/Swiss-Prot Function:
Nuclear monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin and regulates the SRF signaling. Acts by modifying nuclear actin subunits through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament severing and prevent repolymerization. Acts as a key regulator of the SRF signaling pathway elicited by nerve growth factor and serum: mediates oxidation and subsequent depolymerization of nuclear actin, leading to increase MKL1/MRTF-A presence in the nucleus and promote SRF:MKL1/MRTF-A-dependent gene transcription. Does not activate SRF:MKL1/MRTF-A through RhoA.

Enzyme Numbers (IUBMB) for MICAL2 Gene

Gene Ontology (GO) - Molecular Function for MICAL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding ISS --
GO:0004497 monooxygenase activity IEA --
GO:0008270 zinc ion binding IEA --
GO:0016491 oxidoreductase activity IEA --
GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen ISS --
genes like me logo Genes that share ontologies with MICAL2: view
genes like me logo Genes that share phenotypes with MICAL2: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MICAL2 Gene

Localization for MICAL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MICAL2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MICAL2 Gene COMPARTMENTS Subcellular localization image for MICAL2 gene
Compartment Confidence
nucleus 5
cytosol 3
golgi apparatus 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for MICAL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 24440334
genes like me logo Genes that share ontologies with MICAL2: view

Pathways & Interactions for MICAL2 Gene

SuperPathways for MICAL2 Gene

No Data Available

Interacting Proteins for MICAL2 Gene

Gene Ontology (GO) - Biological Process for MICAL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001947 heart looping ISS --
GO:0007010 cytoskeleton organization IDA 24440334
GO:0007507 heart development ISS --
GO:0010735 positive regulation of transcription via serum response element binding IMP 24440334
GO:0019417 sulfur oxidation ISS --
genes like me logo Genes that share ontologies with MICAL2: view

No data available for Pathways by source and SIGNOR curated interactions for MICAL2 Gene

Drugs & Compounds for MICAL2 Gene

(3) Drugs for MICAL2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
FAD Approved Pharma 0
Oxygen Approved, Vet_approved Pharma 0
Water Approved Pharma 0

(2) Additional Compounds for MICAL2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
NADP
  • Adenine-nicotinamide dinucleotide phosphate
  • b-NADP
  • b-Nicotinamide adenine dinucleotide phosphate
  • b-TPN
  • beta-NADP
53-59-8
nadph
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-D-ribofuranosyl-3-pyridinecarboxamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosyl-3-pyridinecarboxamide
  • b-NADPH
53-57-6
genes like me logo Genes that share compounds with MICAL2: view

Transcripts for MICAL2 Gene

Unigene Clusters for MICAL2 Gene

Microtubule associated monoxygenase, calponin and LIM domain containing 2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MICAL2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b · 12c ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^
SP1: - - - - - - - - -
SP2: - - - - - - - - -
SP3: - - -
SP4: - - -
SP5:
SP6:
SP7:
SP8: - - - -
SP9:
SP10:
SP11: - -
SP12: - - -
SP13: - -
SP14: - - - - -
SP15: - -
SP16:

ExUns: 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22a · 22b ^ 23 ^ 24a · 24b ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32a · 32b · 32c ^ 33 ^ 34a · 34b ^ 35a · 35b · 35c ^
SP1: - - - - - -
SP2: - - - - - -
SP3: - - - - - - - -
SP4: - - - - - - - - -
SP5: - - - - - - - - -
SP6: - - - -
SP7: -
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

Relevant External Links for MICAL2 Gene

GeneLoc Exon Structure for
MICAL2
ECgene alternative splicing isoforms for
MICAL2

Expression for MICAL2 Gene

mRNA expression in normal human tissues for MICAL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MICAL2 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x8.0) and Brain - Cerebellum (x7.6).

Protein differential expression in normal tissues from HIPED for MICAL2 Gene

This gene is overexpressed in Breast (64.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MICAL2 Gene



NURSA nuclear receptor signaling pathways regulating expression of MICAL2 Gene:

MICAL2

SOURCE GeneReport for Unigene cluster for MICAL2 Gene:

Hs.501928
genes like me logo Genes that share expression patterns with MICAL2: view

Primer Products

No data available for Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MICAL2 Gene

Orthologs for MICAL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for MICAL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MICAL2 34 35
  • 99.29 (n)
dog
(Canis familiaris)
Mammalia MICAL2 34 35
  • 90.46 (n)
cow
(Bos Taurus)
Mammalia MICAL2 34 35
  • 89.54 (n)
mouse
(Mus musculus)
Mammalia Mical2 34 16 35
  • 86.47 (n)
rat
(Rattus norvegicus)
Mammalia Mical2 34
  • 85.62 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MICAL2 35
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MICAL2 35
  • 46 (a)
OneToOne
chicken
(Gallus gallus)
Aves MICAL2 34 35
  • 71.06 (n)
lizard
(Anolis carolinensis)
Reptilia MICAL2 35
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100487018 34
  • 66.94 (n)
zebrafish
(Danio rerio)
Actinopterygii mical2b 34 35
  • 68.27 (n)
MICAL2 (3 of 3) 35
  • 63 (a)
OneToMany
mical2a 35
  • 62 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6941 34
fruit fly
(Drosophila melanogaster)
Insecta Mical 35
  • 9 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 49 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1958 34
Species where no ortholog for MICAL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MICAL2 Gene

ENSEMBL:
Gene Tree for MICAL2 (if available)
TreeFam:
Gene Tree for MICAL2 (if available)

Paralogs for MICAL2 Gene

(3) SIMAP similar genes for MICAL2 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with MICAL2: view

Variants for MICAL2 Gene

Sequence variations from dbSNP and Humsavar for MICAL2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs869025227 Uncertain significance 12,256,960(+) CTTTG(A/G)CTGCG nc-transcript-variant, reference, missense
rs1008759 -- 12,138,319(+) CTTGG(A/T)GGAGA intron-variant, upstream-variant-2KB
rs1009087 -- 12,140,902(-) CCTTC(C/T)TCCTC intron-variant
rs1009088 -- 12,140,701(-) ATGTC(A/T)GGAGG intron-variant
rs10160563 -- 12,119,635(+) AGGCC(C/T)GCCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MICAL2 Gene

Variant ID Type Subtype PubMed ID
dgv1059n100 CNV gain 25217958
dgv588n106 CNV deletion 24896259
esv2252219 CNV deletion 18987734
esv2664585 CNV deletion 23128226
esv2744115 CNV deletion 23290073
esv2744116 CNV deletion 23290073
esv3547333 CNV deletion 23714750
esv3625389 CNV loss 21293372
esv4083 CNV loss 18987735
esv5666 CNV loss 19470904
nsv1044963 CNV loss 25217958
nsv1049089 CNV loss 25217958
nsv1076415 CNV deletion 25765185
nsv1151675 CNV deletion 26484159
nsv467708 CNV loss 19166990
nsv472704 CNV novel sequence insertion 20440878
nsv483000 CNV loss 15286789
nsv515573 CNV loss 19592680
nsv553545 CNV loss 21841781
nsv553546 CNV loss 21841781
nsv832068 CNV gain 17160897

Variation tolerance for MICAL2 Gene

Residual Variation Intolerance Score: 76.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.95; 68.00% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MICAL2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MICAL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MICAL2 Gene

Disorders for MICAL2 Gene

Relevant External Links for MICAL2

Genetic Association Database (GAD)
MICAL2
Human Genome Epidemiology (HuGE) Navigator
MICAL2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MICAL2

No disorders were found for MICAL2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MICAL2 Gene

Publications for MICAL2 Gene

  1. MICALs, a family of conserved flavoprotein oxidoreductases, function in plexin-mediated axonal repulsion. (PMID: 12110185) Terman J.R. … Kolodkin A.L. (Cell 2002) 2 3 4 64
  2. Redox modification of nuclear actin by MICAL-2 regulates SRF signaling. (PMID: 24440334) Lundquist M.R. … Jaffrey S.R. (Cell 2014) 3 4 64
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  4. Expression of novel molecules, MICAL2-PV (MICAL2 prostate cancer variants), increases with high Gleason score and prostate cancer progression. (PMID: 16675569) Ashida S. … Nakagawa H. (Clin. Cancer Res. 2006) 3 4 64
  5. The MICAL proteins and rab1: a possible link to the cytoskeleton? (PMID: 15694364) Fischer J. … Barnekow A. (Biochem. Biophys. Res. Commun. 2005) 3 4 64

Products for MICAL2 Gene

Sources for MICAL2 Gene

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