Aliases for MICAL1 Gene
External Ids for MICAL1 Gene
Previous HGNC Symbols for MICAL1 Gene
Previous GeneCards Identifiers for MICAL1 Gene
GeneCards Summary for MICAL1 Gene
MICAL1 (Microtubule Associated Monooxygenase, Calponin And LIM Domain Containing 1) is a Protein Coding gene. GO annotations related to this gene include actin binding and FAD binding. An important paralog of this gene is SMTNL2.
UniProtKB/Swiss-Prot for MICAL1 Gene
Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin. Acts by modifying actin subunits through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament severing and prevent repolymerization (Probable). Acts as a cytoskeletal regulator that connects NEDD9 to intermediate filaments. Also acts as a negative regulator of apoptosis via its interaction with STK38 and STK38L; acts by antagonizing STK38 and STK38L activation by MST1/STK4.