Aliases for MICAL1 Gene
External Ids for MICAL1 Gene
Previous Symbols for MICAL1 Gene
GeneCards Summary for MICAL1 Gene
MICAL1 (Microtubule Associated Monooxygenase, Calponin And LIM Domain Containing 1) is a Protein Coding gene. GO annotations related to this gene include actin binding and FAD binding. An important paralog of this gene is SMTNL2.
UniProtKB/Swiss-Prot for MICAL1 Gene
Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin. Acts by modifying actin subunits through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament severing and prevent repolymerization (Probable). Acts as a cytoskeletal regulator that connects NEDD9 to intermediate filaments. Also acts as a negative regulator of apoptosis via its interaction with STK38 and STK38L; acts by antagonizing STK38 and STK38L activation by MST1/STK4.