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MICAL1 Gene

protein-coding   GIFtS: 55
GCID: GC06M109766

Microtubule Associated Monooxygenase, Calponin And LIM Domain...

(Previous name: NEDD9 interacting protein with calponin homology and LIM...)
(Previous symbol: NICAL)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Microtubule Associated Monooxygenase, Calponin And LIM Domain
Containing 11 2
     NEDD9 Interacting Protein With Calponin Homology And LIM Domains1
NICAL1 2 3 5     CasL Interacting Molecule2
MICAL2 3 5     Microtubule Associated Monoxygenase, Calponin And LIM Domain Containing 12
Molecule Interacting With CasL Protein 12 3     Protein-Methionine Sulfoxide Oxidase MICAL12
MICAL-12 3     EC 1.14.13.-3
NEDD9-Interacting Protein With Calponin Homology And LIM Domains2 3     

External Ids:    HGNC: 206191   Entrez Gene: 647802   Ensembl: ENSG000001355967   OMIM: 6071295   UniProtKB: Q8TDZ23   

Export aliases for MICAL1 gene to outside databases

Previous GC identifers: GC06M109872 GC06M107331


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MICAL1 Gene:
MICAL1 (microtubule associated monooxygenase, calponin and LIM domain containing 1) is a protein-coding gene. Diseases associated with MICAL1 include anthracosilicosis, and breast and colorectal cancer. GO annotations related to this gene include actin binding and FAD binding. An important paralog of this gene is MICALL2.

UniProtKB/Swiss-Prot: MICA1_HUMAN, Q8TDZ2
Function: Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine
residues on actin. Acts by modifying actin subunits through the addition of oxygen to form methionine-sulfoxide,
leading to promote actin filament severing and prevent repolymerization (Probable). Acts as a cytoskeletal
regulator that connects NEDD9 to intermediate filaments. Also acts as a negative regulator of apoptosis via its
interaction with STK38 and STK38L; acts by antagonizing STK38 and STK38L activation by MST1/STK4

Gene Wiki entry for MICAL1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NC_018917.2  NT_025741.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the MICAL1 gene promoter:
         Pax-5   HOXA5   FOXJ2 (long isoform)   MyoD   FOXJ2   Pax-4a   ITF-2   Tal-1beta   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): MICAL1 promoter sequence
   Search Chromatin IP Primers for MICAL1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MICAL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q21   Ensembl cytogenetic band:  6q21   HGNC cytogenetic band: 6q21

MICAL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MICAL1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M109766:  view genomic region     (about GC identifiers)

Start:
109,765,265 bp from pter      End:
109,787,171 bp from pter
Size:
21,907 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: MICA1_HUMAN, Q8TDZ2 (See protein sequence)
Recommended Name: Protein-methionine sulfoxide oxidase MICAL1  
Size: 1067 amino acids; 117875 Da
Cofactor: FAD
Subunit: Interacts with STK38 and STK38L (By similarity). Interacts with RAB8A (By similarity). Associates with
the SH3 domain of NEDD9. Interacts with VIM and PLXNA3. Interacts with RAB1B
3 PDB 3D structures from and Proteopedia for MICAL1:
1WYL (3D)        2CO8 (3D)        2DK9 (3D)    
Secondary accessions: B7Z3R5 E1P5F0 Q7Z633 Q8IVS9 Q96G47 Q9H6X6 Q9H7I0 Q9HAA1 Q9UFF7
Alternative splicing: 4 isoforms:  Q8TDZ2-1   Q8TDZ2-2   Q8TDZ2-3   Q8TDZ2-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MICAL1: NX_Q8TDZ2

Explore proteomics data for MICAL1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys488, Lys637
  • Modification sites at PhosphoSitePlus

  • See MICAL1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001152763.1  NP_001273542.1  NP_073602.3  

    ENSEMBL proteins: 
     ENSP00000351664   ENSP00000408924   ENSP00000407075   ENSP00000357948   ENSP00000351385  

    MICAL1 Human Recombinant Protein Products:

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    Novus Biologicals MICAL1 Proteins
    Novus Biologicals MICAL1 Lysates
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    Cloud-Clone Corp. Proteins for MICAL1

    MICAL1 Antibody Products:

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    MICAL1 Assay Products:

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    Cloud-Clone Corp. CLIAs for MICAL1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR022735 DUF3585
     IPR002938 mOase_FAD-bd
     IPR001715 CH-domain
     IPR001781 Znf_LIM

    Graphical View of Domain Structure for InterPro Entry Q8TDZ2

    ProtoNet protein and cluster: Q8TDZ2

    3 Blocks protein domains:
    IPB001715 Calponin-like actin-binding
    IPB001781 Zn-binding protein
    IPB002938 Monooxygenase


    UniProtKB/Swiss-Prot: MICA1_HUMAN, Q8TDZ2
    Domain: The C-terminal coiled coil part contains the plexin-interacting region
    Similarity: Belongs to the Mical family
    Similarity: Contains 1 CH (calponin-homology) domain
    Similarity: Contains 1 LIM zinc-binding domain


    MICAL1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MICA1_HUMAN, Q8TDZ2
    Function: Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine
    residues on actin. Acts by modifying actin subunits through the addition of oxygen to form methionine-sulfoxide,
    leading to promote actin filament severing and prevent repolymerization (Probable). Acts as a cytoskeletal
    regulator that connects NEDD9 to intermediate filaments. Also acts as a negative regulator of apoptosis via its
    interaction with STK38 and STK38L; acts by antagonizing STK38 and STK38L activation by MST1/STK4
    Catalytic activity: [protein]-methionine + NADPH + O(2) = [protein]-methionine-sulfoxide + NADP(+) + H(2)O
    Biophysicochemical properties: Kinetic parameters: KM=4.7 uM for F-actin (at saturing NADPH concentration);

         Enzyme Number (IUBMB): EC 1.14.13.-1

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IDA--
    GO:0004497monooxygenase activity ----
    GO:0005515protein binding IPI11827972
    GO:0008270zinc ion binding IEA--
    GO:0016709oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen IDA--
         
    MICAL1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for MICAL1:
     Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MICAL1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MICAL1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MICAL1

    miRNA
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    miRTarBase miRNAs that target MICAL1:
    hsa-mir-149-5p (MIRT045642), hsa-mir-124-3p (MIRT023104)

    Block miRNA regulation of human, mouse, rat MICAL1 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate MICAL1:
    hsa-miR-30c hsa-miR-30a hsa-miR-30b hsa-miR-30d hsa-miR-30e
    SwitchGear 3'UTR luciferase reporter plasmidMICAL1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat MICAL1

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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MICAL1

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MICA1_HUMAN, Q8TDZ2: Cytoplasm. Cytoplasm, cytoskeleton
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol3
    golgi apparatus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA11827972
    GO:0005882intermediate filament NAS11827972

    MICAL1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MICAL1
    Interactions:

        GeneGlobe Interaction Network for MICAL1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MICAL1 (Q8TDZ22, 3 ENSP000003516644) via UniProtKB, MINT, STRING, and/or I2D (see all 34)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GADD45AP245222, 3MINT-8255934 I2D: score=2 
    GSK3BP498412, 3MINT-8257471 I2D: score=2 
    PIK3R3Q925692, 3MINT-8266282 I2D: score=2 
    RPS6KA6Q9UK322, 3MINT-8269879 I2D: score=2 
    TAB1Q157502, 3MINT-8260196 I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001933negative regulation of protein phosphorylation IEA--
    GO:0007010cytoskeleton organization NAS11827972
    GO:0007165signal transduction NAS11827972
    GO:0019417sulfur oxidation ISS--
    GO:0030042actin filament depolymerization IDA--

    MICAL1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MICAL1 (MICA1)

    1 HMDB Compound for MICAL1    About this table
    CompoundSynonyms CAS #PubMed Ids
    FAD1H-Purin-6-amine flavin dinucleotide (see all 21)146-14-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MICAL1 gene (3 alternative transcripts): 
    NM_001159291.1  NM_001286613.1  NM_022765.3  

    Unigene Cluster for MICAL1:

    Microtubule associated monoxygenase, calponin and LIM domain containing 1
    Hs.33476  [show with all ESTs]
    Unigene Representative Sequence: AK024500
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000456101 ENST00000358807(uc003ptj.3 uc003ptk.3 uc010kdr.3)
    ENST00000465904 ENST00000433205 ENST00000483856 ENST00000431946 ENST00000368952(uc011eaq.2)
    ENST00000358577
    miRNA
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    5 qRT-PCR Assays for microRNAs that regulate MICAL1:
    hsa-miR-30c hsa-miR-30a hsa-miR-30b hsa-miR-30d hsa-miR-30e
    SwitchGear 3'UTR luciferase reporter plasmidMICAL1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat MICAL1
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    GenScript: all cDNA clones in your preferred vector (see all 2): MICAL1 (NM_022765)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MICAL1
    Primer
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    OriGene qPCR primer pairs and template standards for MICAL1
    OriGene qSTAR qPCR primer pairs in human, mouse for MICAL1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MICAL1
      QuantiTect SYBR Green Assays in human, mouse, rat MICAL1
      QuantiFast Probe-based Assays in human, mouse, rat MICAL1

    Additional mRNA sequence: 

    AB048948.1 AK021999.1 AK024500.1 AK025392.1 AK225049.1 AK296284.1 AL122098.1 BC009972.2 
    BC036514.1 BC042144.1 BC052983.1 

    20 DOTS entries:

    DT.87017266  DT.95274656  DT.92456736  DT.100818386  DT.97769804  DT.100835424  DT.92456723  DT.95274660 
    DT.100818390  DT.95274657  DT.100818382  DT.99998086  DT.100829875  DT.102827435  DT.121341265  DT.121341268 
    DT.100810466  DT.100830290  DT.121341235  DT.91662419 

    Selected AceView cDNA sequences (see all 205):

    BU729666 BQ707133 CD365133 BM702005 AI523970 BQ054404 BQ065257 BQ229753 
    BM511745 BX420992 BU732130 CB216868 BE773580 AI914077 CD300619 BI825146 
    BF908155 BG764163 CF619327 BM677041 AK021999 AI673370 AU125837 AI805253 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MICAL1 (see all 23)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9 ^ 10 ^
    SP1:                    -     -     -     -     -     -     -     -     -     -     -     -                                                                     
    SP2:                                            -     -     -     -     -                 -                                                                     
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 11 ^ 12a · 12b ^ 13a · 13b · 13c ^ 14a · 14b ^ 15 ^ 16a · 16b · 16c ^ 17a · 17b · 17c · 17d ^ 18 ^ 19a · 19b ^ 20 ^ 21a · 21b ^ 22 ^ 23a · 23b ^ 24a ·
    SP1:  -                 -                       -                       -     -                                                                       -         
    SP2:                    -                       -                       -     -                                                                       -     -   
    SP3:  -                 -     -     -           -                       -     -                                                                       -         
    SP4:                    -                       -           -                 -     -                                                                 -         
    SP5:                                                                                                                                                  -         

    ExUns: 24b ^ 25a · 25b · 25c ^ 26a · 26b ^ 27 ^ 28a · 28b ^ 29 ^ 30a · 30b ^ 31
    SP1:        -     -                                   -           -               
    SP2:        -     -                                   -           -               
    SP3:        -     -                                   -           -               
    SP4:        -     -                                   -           -               
    SP5:                                                                              


    ECgene alternative splicing isoforms for MICAL1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MICAL1 expression in normal human tissues (normalized intensities)      MICAL1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AACCGGGAAG
    MICAL1 Expression
    About this image


    MICAL1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Brain (Nervous System)
             Adult Oligodendrocyte Precursor Cells Lateral Ventricle
     
     Spleen (Hematopoietic System)
    MICAL1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MICAL1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.33476

    UniProtKB/Swiss-Prot: MICA1_HUMAN, Q8TDZ2
    Tissue specificity: Expressed in the thymus, lung, spleen, kidney, testis and hematopoietic cells

        Custom PCR Arrays for MICAL1
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MICAL1 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mical11 , 5 microtubule associated monoxygenase, calponin and LIM more5
    microtubule associated monooxygenase, calponin and more1
    83.06(n)1
    82.04(a)1
      10 (22.41 cM)5
    1715801  NM_138315.21  NP_612188.11 
     414763145 
    chicken
    (Gallus gallus)
    Aves MICAL11 microtubule associated monoxygenase, calponin and LIM more 65.09(n)
    59.54(a)
      429474  NM_001031576.1  NP_001026747.1 
    lizard
    (Anolis carolinensis)
    Reptilia MICAL16
    microtubule associated monooxygenase, calponin and...
    64(a)
    1 ↔ 1
    4(124287054-124340136)
    zebrafish
    (Danio rerio)
    Actinopterygii mical16
    microtubule associated monooxygenase, calponin and...
    38(a)
    1 ↔ 1
    23(39607730-39680259) ENSDARG00000011809
    fruit fly
    (Drosophila melanogaster)
    Insecta Mical6
    Molecule interacting with CasL
    9(a)
    1 → many
    3R(5827276-5868617)


    ENSEMBL Gene Tree for MICAL1 (if available)
    TreeFam Gene Tree for MICAL1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MICAL1 gene
    MICALL22  MICAL22  EHBP12  MICAL32  SPECC12  SMTNL22  MICALL12  MICALCL2  
    SPECC1L-ADORA2A2  SMTN2  EHBP1L12  SPECC1L2  SMTNL12  
    3 SIMAP similar genes for MICAL1 using alignment to 5 protein entries:     MICA1_HUMAN (see all proteins):
    MICAL2    DMD    MICAL3

    MICAL1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MICAL1 (see all 513)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0361914
    A breast cancer sample4--see VAR_0361912 L M mis40--------
    rs1892348511,2
    --109765624(+) ATGTGA/GTTTCT 2 -- int10--------
    rs1914146271,2
    --109765761(+) CTGATG/TGAACT 2 -- int10--------
    rs21464111,2
    C--109765788(+) TTGGAG/CCCCCC 2 -- int15Minor allele frequency- C:0.11EA CSA WA NA 1270
    rs1117757571,2
    C,F--109765810(+) CCTCCT/CGAATT 2 -- int11Minor allele frequency- C:0.01NA 120
    rs22365821,2
    C,F,O,H--109765818(-) TCTGAG/CACAAT 2 -- int128Minor allele frequency- C:0.35EA NA NS WA CSA 4327
    rs1837006031,2
    --109765840(+) TAGAGC/TATCAT 2 -- int10--------
    rs613038541,2
    C,F--109765870(+) AGATCA/GTGAGG 2 -- int13Minor allele frequency- G:0.37WA CSA 122
    rs778047031,2
    --109765871(+) GATCAC/TGAGGC 2 -- int10--------
    rs1438881931,2
    C--109765883(+) TGCATC/GACACA 2 -- int10--------

    HapMap Linkage Disequilibrium report for MICAL1 (109765265 - 109787171 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for MICAL1: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MICAL1
    DNA2.0 Custom Variant and Variant Library Synthesis for MICAL1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607129    OMIM disorders: --

    3 diseases for MICAL1:    About MalaCards
    anthracosilicosis    breast and colorectal cancer    colorectal cancer


    MICAL1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): MICAL1
    Human Genome Epidemiology (HuGE) Navigator: MICAL1 (4 documents)

    Export disorders for MICAL1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MICAL1 gene, integrated from 10 sources (see all 32):
    (articles sorted by number of sources associating them with MICAL1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. MICAL, a novel CasL interacting molecule, associates with vimentin. (PubMed id 11827972)1, 2, 3 Suzuki T.... Hirai H. (J. Biol. Chem. 2002)
    2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    3. Investigation of the four cooperative unfolding units existing in the MICAL-1 CH domain. (PubMed id 17662518)1, 2 Jin X.... Shi Y. (Biophys. Chem. 2007)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    5. The MICAL proteins and rab1: a possible link to the cytoskeleton? (PubMed id 15694364)1, 2 Fischer J.... Barnekow A. (Biochem. Biophys. Res. Commun. 2005)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. MICAL-1 isoforms, novel rab1 interacting proteins. (PubMed id 12788069)1, 2 Weide T.... Barnekow A. (Biochem. Biophys. Res. Commun. 2003)
    9. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    10. MICALs, a family of conserved flavoprotein oxidoreductases, function in plexin-mediated axonal repulsion. (PubMed id 12110185)1, 2 Terman J.R.... Kolodkin A.L. (Cell 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 64780 HGNC: 20619 AceView: NICAL Ensembl:ENSG00000135596 euGenes: HUgn64780
    ECgene: MICAL1 H-InvDB: MICAL1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MICAL1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MICAL1 gene:
    Search GeneIP for patents involving MICAL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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