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Aliases for MICAL1 Gene

Aliases for MICAL1 Gene

  • Microtubule Associated Monooxygenase, Calponin And LIM Domain Containing 1 2 3 5
  • NEDD9-Interacting Protein With Calponin Homology And LIM Domains 3 4
  • Protein-Methionine Sulfoxide Oxidase MICAL1 2 3
  • Molecule Interacting With CasL Protein 1 3 4
  • MICAL-1 3 4
  • NICAL 3 4
  • MICAL 3 4
  • NEDD9 Interacting Protein With Calponin Homology And LIM Domains 2
  • EC 1.14.13.- 4

External Ids for MICAL1 Gene

Previous HGNC Symbols for MICAL1 Gene

  • NICAL

Previous GeneCards Identifiers for MICAL1 Gene

  • GC06M109872
  • GC06M109766
  • GC06M107331

Summaries for MICAL1 Gene

Entrez Gene Summary for MICAL1 Gene

  • This gene encodes an enzyme that oxidizes methionine residues on actin, thereby promoting depolymerization of actin filaments. This protein interacts with and regulates signalling by NEDD9/CAS-L (neural precursor cell expressed, developmentally down-regulated 9). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]

GeneCards Summary for MICAL1 Gene

MICAL1 (Microtubule Associated Monooxygenase, Calponin And LIM Domain Containing 1) is a Protein Coding gene. Diseases associated with MICAL1 include Anthracosilicosis. Among its related pathways are Glucose / Energy Metabolism. GO annotations related to this gene include actin binding and Rab GTPase binding. An important paralog of this gene is MICAL3.

UniProtKB/Swiss-Prot for MICAL1 Gene

  • Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin. Acts by modifying actin subunits through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament severing and prevent repolymerization (Probable). Acts as a cytoskeletal regulator that connects NEDD9 to intermediate filaments. Also acts as a negative regulator of apoptosis via its interaction with STK38 and STK38L; acts by antagonizing STK38 and STK38L activation by MST1/STK4.

Gene Wiki entry for MICAL1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MICAL1 Gene

Genomics for MICAL1 Gene

Regulatory Elements for MICAL1 Gene

Enhancers for MICAL1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around MICAL1 on UCSC Golden Path with GeneCards custom track

Genomic Location for MICAL1 Gene

Chromosome:
6
Start:
109,444,062 bp from pter
End:
109,465,968 bp from pter
Size:
21,907 bases
Orientation:
Minus strand

Genomic View for MICAL1 Gene

Genes around MICAL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MICAL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MICAL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MICAL1 Gene

Proteins for MICAL1 Gene

  • Protein details for MICAL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TDZ2-MICA1_HUMAN
    Recommended name:
    Protein-methionine sulfoxide oxidase MICAL1
    Protein Accession:
    Q8TDZ2
    Secondary Accessions:
    • B7Z3R5
    • E1P5F0
    • Q7Z633
    • Q8IVS9
    • Q96G47
    • Q9H6X6
    • Q9H7I0
    • Q9HAA1
    • Q9UFF7

    Protein attributes for MICAL1 Gene

    Size:
    1067 amino acids
    Molecular mass:
    117875 Da
    Cofactor:
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Quaternary structure:
    • Interacts with STK38 and STK38L (By similarity). Interacts with RAB8A (By similarity). Associates with the SH3 domain of NEDD9. Interacts with VIM and PLXNA3. Interacts with RAB1B.

    Three dimensional structures from OCA and Proteopedia for MICAL1 Gene

    Alternative splice isoforms for MICAL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MICAL1 Gene

Post-translational modifications for MICAL1 Gene

  • Ubiquitination at Lys 488 and Lys 637
  • Modification sites at PhosphoSitePlus

Other Protein References for MICAL1 Gene

No data available for DME Specific Peptides for MICAL1 Gene

Domains & Families for MICAL1 Gene

Gene Families for MICAL1 Gene

Graphical View of Domain Structure for InterPro Entry

Q8TDZ2

UniProtKB/Swiss-Prot:

MICA1_HUMAN :
  • The C-terminal coiled coil part contains the plexin-interacting region.
  • Belongs to the Mical family.
Domain:
  • The C-terminal coiled coil part contains the plexin-interacting region.
  • Contains 1 CH (calponin-homology) domain.
  • Contains 1 LIM zinc-binding domain.
Family:
  • Belongs to the Mical family.
genes like me logo Genes that share domains with MICAL1: view

Function for MICAL1 Gene

Molecular function for MICAL1 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=4.7 uM for F-actin (at saturing NADPH concentration) {ECO:0000269 PubMed:21864500};
UniProtKB/Swiss-Prot CatalyticActivity:
[protein]-methionine + NADPH + O(2) = [protein]-methionine-sulfoxide + NADP(+) + H(2)O.
UniProtKB/Swiss-Prot Function:
Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin. Acts by modifying actin subunits through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament severing and prevent repolymerization (Probable). Acts as a cytoskeletal regulator that connects NEDD9 to intermediate filaments. Also acts as a negative regulator of apoptosis via its interaction with STK38 and STK38L; acts by antagonizing STK38 and STK38L activation by MST1/STK4.

Enzyme Numbers (IUBMB) for MICAL1 Gene

Gene Ontology (GO) - Molecular Function for MICAL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA,IDA 21864500
GO:0004497 monooxygenase activity IEA --
GO:0005515 protein binding IEA,IPI 11827972
GO:0008270 zinc ion binding IEA --
GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen IEA,IDA 21864500
genes like me logo Genes that share ontologies with MICAL1: view
genes like me logo Genes that share phenotypes with MICAL1: view

Animal Model Products

CRISPR Products

miRNA for MICAL1 Gene

miRTarBase miRNAs that target MICAL1

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MICAL1 Gene

Localization for MICAL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MICAL1 Gene

Cytoplasm. Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MICAL1 Gene COMPARTMENTS Subcellular localization image for MICAL1 gene
Compartment Confidence
cytoskeleton 5
cytosol 4
nucleus 3
plasma membrane 3
endosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for MICAL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 11827972
GO:0005882 intermediate filament NAS 11827972
genes like me logo Genes that share ontologies with MICAL1: view

Pathways & Interactions for MICAL1 Gene

SuperPathways for MICAL1 Gene

Superpath Contained pathways
1 Glucose / Energy Metabolism
genes like me logo Genes that share pathways with MICAL1: view

Pathways by source for MICAL1 Gene

1 Cell Signaling Technology pathway for MICAL1 Gene

Gene Ontology (GO) - Biological Process for MICAL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001933 negative regulation of protein phosphorylation IEA --
GO:0007010 cytoskeleton organization NAS 11827972
GO:0007165 signal transduction NAS 11827972
GO:0019417 sulfur oxidation IEA,ISS --
GO:0030042 actin filament depolymerization IEA,IDA 21864500
genes like me logo Genes that share ontologies with MICAL1: view

No data available for SIGNOR curated interactions for MICAL1 Gene

Drugs & Compounds for MICAL1 Gene

(3) Drugs for MICAL1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
FAD Approved Pharma 0
Oxygen Approved, Vet_approved Pharma 0
Water Approved Pharma 0

(2) Additional Compounds for MICAL1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
NADP
  • Adenine-nicotinamide dinucleotide phosphate
  • b-NADP
  • b-Nicotinamide adenine dinucleotide phosphate
  • b-TPN
  • beta-NADP
53-59-8
nadph
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-D-ribofuranosyl-3-pyridinecarboxamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosyl-3-pyridinecarboxamide
  • b-NADPH
53-57-6
genes like me logo Genes that share compounds with MICAL1: view

Transcripts for MICAL1 Gene

Unigene Clusters for MICAL1 Gene

Microtubule associated monoxygenase, calponin and LIM domain containing 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MICAL1 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9 ^ 10 ^
SP1: - - - - - - - - - - - -
SP2: - - - - - -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9: - - - - - - - -
SP10:
SP11:
SP12:
SP13: - - - - - - -
SP14: - - - - - -
SP15:
SP16: - - - - - - - - - - - - - -
SP17: - - - - - - - -
SP18: - -
SP19: - - - - -
SP20:
SP21:
SP22:
SP23:

ExUns: 11 ^ 12a · 12b ^ 13a · 13b · 13c ^ 14a · 14b ^ 15 ^ 16a · 16b · 16c ^ 17a · 17b · 17c · 17d ^ 18 ^ 19a · 19b ^ 20 ^ 21a · 21b ^ 22 ^ 23a · 23b ^ 24a ·
SP1: - - - - - -
SP2: - - - - - -
SP3: - - - - - - - -
SP4: - - - - - -
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10: - - - - -
SP11: - - -
SP12:
SP13:
SP14:
SP15: - - -
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:

ExUns: 24b ^ 25a · 25b · 25c ^ 26a · 26b ^ 27 ^ 28a · 28b ^ 29 ^ 30a · 30b ^ 31
SP1: - - - -
SP2: - - - -
SP3: - - - -
SP4: - - - -
SP5:
SP6: - -
SP7: -
SP8: - - -
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:

Relevant External Links for MICAL1 Gene

GeneLoc Exon Structure for
MICAL1
ECgene alternative splicing isoforms for
MICAL1

Expression for MICAL1 Gene

mRNA expression in normal human tissues for MICAL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MICAL1 Gene

This gene is overexpressed in Whole Blood (x8.7).

Protein differential expression in normal tissues from HIPED for MICAL1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (21.0), Lymph node (18.4), and Monocytes (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MICAL1 Gene



Protein tissue co-expression partners for MICAL1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MICAL1 Gene:

MICAL1

SOURCE GeneReport for Unigene cluster for MICAL1 Gene:

Hs.33476

mRNA Expression by UniProt/SwissProt for MICAL1 Gene:

Q8TDZ2-MICA1_HUMAN
Tissue specificity: Expressed in the thymus, lung, spleen, kidney, testis and hematopoietic cells.
genes like me logo Genes that share expression patterns with MICAL1: view

Primer Products

Orthologs for MICAL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for MICAL1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MICAL1 34
  • 86.47 (n)
  • 85.85 (a)
MICAL1 35
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MICAL1 34
  • 84.15 (n)
  • 82.15 (a)
MICAL1 35
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mical1 34
  • 83.06 (n)
  • 82.04 (a)
Mical1 16
Mical1 35
  • 81 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MICAL1 34
  • 99.2 (n)
  • 98.99 (a)
MICAL1 35
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mical1 34
  • 82.32 (n)
  • 79.83 (a)
oppossum
(Monodelphis domestica)
Mammalia MICAL1 35
  • 62 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MICAL1 35
  • 51 (a)
OneToOne
chicken
(Gallus gallus)
Aves MICAL1 34
  • 65.09 (n)
  • 59.54 (a)
MICAL1 35
  • 49 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MICAL1 35
  • 64 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii mical1 35
  • 38 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Mical 35
  • 9 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 39 (a)
OneToMany
Species where no ortholog for MICAL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MICAL1 Gene

ENSEMBL:
Gene Tree for MICAL1 (if available)
TreeFam:
Gene Tree for MICAL1 (if available)

Paralogs for MICAL1 Gene

(3) SIMAP similar genes for MICAL1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with MICAL1: view

Variants for MICAL1 Gene

Sequence variations from dbSNP and Humsavar for MICAL1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs9320288 - 109,446,727(+) CTTCC(G/T)CTTTG reference, missense
VAR_036191 A breast cancer sample
rs4946977 -, - 109,454,163(+) GTGGG(C/T)ATGCG reference, missense
rs34726911 - 109,453,646(-) CCTGG(A/C)CCACA reference, missense
rs59056467 -, - 109,446,728(+) TTCCG(C/G/T)TTTGT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for MICAL1 Gene

Variant ID Type Subtype PubMed ID
esv3576210 CNV gain 25503493
esv3610337 CNV loss 21293372
esv3610338 CNV gain 21293372
nsv1074006 CNV deletion 25765185
nsv950493 CNV deletion 24416366

Variation tolerance for MICAL1 Gene

Residual Variation Intolerance Score: 64.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.30; 85.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MICAL1 Gene

Human Gene Mutation Database (HGMD)
MICAL1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MICAL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MICAL1 Gene

Disorders for MICAL1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MICAL1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
anthracosilicosis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for MICAL1

Genetic Association Database (GAD)
MICAL1
Human Genome Epidemiology (HuGE) Navigator
MICAL1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MICAL1
genes like me logo Genes that share disorders with MICAL1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MICAL1 Gene

Publications for MICAL1 Gene

  1. MICAL, a novel CasL interacting molecule, associates with vimentin. (PMID: 11827972) Suzuki T. … Hirai H. (J. Biol. Chem. 2002) 2 3 4 65
  2. Redox modification of nuclear actin by MICAL-2 regulates SRF signaling. (PMID: 24440334) Lundquist M.R. … Jaffrey S.R. (Cell 2014) 3 4 65
  3. Kinetic and spectroscopic characterization of the putative monooxygenase domain of human MICAL-1. (PMID: 21864500) Zucchini D. … Vanoni M.A. (Arch. Biochem. Biophys. 2011) 3 4 65
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 65
  5. Release of MICAL autoinhibition by semaphorin-plexin signaling promotes interaction with collapsin response mediator protein. (PMID: 18305261) Schmidt E.F. … Strittmatter S.M. (J. Neurosci. 2008) 3 4 65

Products for MICAL1 Gene

Sources for MICAL1 Gene

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