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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

MICAL1 Gene

protein-coding GIFtS: 50
GCID: GC06M109766

microtubule associated monoxygenase, calponin and LIM domain...

(Previous name: NEDD9 interacting protein with calponin homology and LIM...)
(Previous symbol: NICAL)

Explore 1 disease affiliated with
MICAL1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Microtubule Associated Monoxygenase, Calponin And LIM Domain Containing 1¹ ²		DKFZp434B1517¹
MICAL¹ ² ³ ⁵		FLJ11937¹
NICAL¹ ² ³ ⁵		FLJ21739¹
NEDD9 Interacting Protein With Calponin Homology And LIM Domains¹ ²		CasL Interacting Molecule²
Molecule Interacting With CasL Protein 1² ³		Protein-Methionine Sulfoxide Oxidase MICAL1²
MICAL-1² ³		EC 1.14.13.-³
NEDD9-Interacting Protein With Calponin Homology And LIM Domains² ³

External Ids:	HGNC: 20619¹	Entrez Gene: 64780²	Ensembl: ENSG00000135596⁷	OMIM: 607129⁵	UniProtKB: Q8TDZ2³

Export aliases for MICAL1 gene to outside databases

Previous GC identifers: GC06M109872 GC06M107331

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: MICA1_HUMAN, Q8TDZ2

Function: Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine

residues on actin. Acts by modifying actin subunits through the addition of oxygen to form methionine-sulfoxide,

leading to promote actin filament severing and prevent repolymerization (Probable). Acts as a cytoskeletal regulator

that connects NEDD9 to intermediate filaments. Also acts as a negative regulator of apoptosis via its interaction with

STK38 and STK38L; acts by antagonizing STK38 and STK38L activation by MST1/STK4

Gene Wiki entry for MICAL1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000006.11 NC_018917.1 NT_025741.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the MICAL1 gene promoter:
Pax-5 HOXA5 FOXJ2 (long isoform) MyoD FOXJ2 Pax-4a ITF-2 Tal-1beta
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): MICAL1 promoter sequence

Search SABiosciences Chromatin IP Primers for MICAL1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MICAL1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q21 Ensembl cytogenetic band: 6q21 HGNC cytogenetic band: 6q21

MICAL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MICAL1 gene location

GeneLoc information about chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06M109766: view genomic region (about GC identifiers)

Start:	109,765,265 bp from pter	End:	109,787,171 bp from pter
Size:	21,907 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MICA1_HUMAN, Q8TDZ2 (See protein sequence)

Recommended Name: Protein-methionine sulfoxide oxidase MICAL1

Size: 1067 amino acids; 117875 Da

Cofactor: FAD

Subunit: Interacts with STK38 and STK38L (By similarity). Associates with the SH3 domain of NEDD9. Interacts with VIM

and PLXNA3. Interacts with RAB1B

Subcellular location: Cytoplasm. Cytoplasm, cytoskeleton

3 PDB 3D structures from and Proteopedia for MICAL1:

1WYL (3D)

2CO8 (3D)

2DK9 (3D)

Secondary accessions: B7Z3R5 E1P5F0 Q7Z633 Q8IVS9 Q96G47 Q9H6X6 Q9H7I0 Q9HAA1 Q9UFF7

Alternative splicing: 4 isoforms: Q8TDZ2-1 Q8TDZ2-2 Q8TDZ2-3 Q8TDZ2-4 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MICAL1: NX_Q8TDZ2

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8TDZ2

MICAL1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001152763.1 NP_073602.3

ENSEMBL proteins:

ENSP00000351664 ENSP00000408924 ENSP00000407075 ENSP00000357948 ENSP00000351385

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	OriGene Purified Protein: MICAL1 OriGene Protein Over-expression Lysate: MICAL1 OriGene Custom Protein Services for MICAL1
	GenScript Custom Purified and Recombinant Proteins Services for MICAL1
	Novus Biologicals MICAL1 Proteins Novus Biologicals MICAL1 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for MICAL1

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IDA	11827972
GO:0005882	intermediate filament	NAS	11827972

MICAL1 for ontologies About GeneDecksing

MICAL1 Antibody Products:

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	Uscn Antibodies for MICAL1
	Search ThermoFisher Antibodies for MICAL1

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	Uscn ELISAs and CLIAs for MICAL1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

MICAL1 for domains About GeneDecksing

4 InterPro domains/families:

IPR022735 DUF3585

IPR002938 mOase_FAD-bd

IPR001715 CH-domain

IPR001781 Znf_LIM

Graphical View of Domain Structure for InterPro Entry Q8TDZ2

ProtoNet protein and cluster: Q8TDZ2

3 Blocks protein families:

IPB001715 Calponin-like actin-binding

IPB001781 Zn-binding protein

IPB002938 Monooxygenase

UniProtKB/Swiss-Prot: MICA1_HUMAN, Q8TDZ2

Domain: The C-terminal coiled coil part contains the plexin-interacting region

Similarity: Belongs to the Mical family

Similarity: Contains 1 CH (calponin-homology) domain

Similarity: Contains 1 LIM zinc-binding domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: MICA1_HUMAN, Q8TDZ2

Function: Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine

residues on actin. Acts by modifying actin subunits through the addition of oxygen to form methionine-sulfoxide,

leading to promote actin filament severing and prevent repolymerization (Probable). Acts as a cytoskeletal regulator

that connects NEDD9 to intermediate filaments. Also acts as a negative regulator of apoptosis via its interaction with

STK38 and STK38L; acts by antagonizing STK38 and STK38L activation by MST1/STK4

Catalytic activity: [protein]-methionine + NADPH + O(2) = [protein]-methionine-sulfoxide + NADP(+) + H(2)O

Biophysicochemical properties: Kinetic parameters: KM=4.7 uM for F-actin (at saturing NADPH concentration);

Enzyme Number (IUBMB): EC 1.14.13.-¹

miRNA Products:		OriGene 3'-UTR Clone (see all 2): MICAL1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MICAL1
		5 QIAGEN miScript miRNA Assays for microRNAs that regulate MICAL1:
		hsa-miR-30c hsa-miR-30a hsa-miR-30b hsa-miR-30d hsa-miR-30e
		SwitchGear 3'UTR luciferase reporter plasmid: MICAL1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MICAL1 (see all 7) OriGene shRNA RFP: MICAL1 OriGene siRNA: MICAL1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MICAL1

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for MICAL1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MICAL1 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MICAL1 (see all 4) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): MICAL1 (NM_022765)
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MICAL1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for MICAL1
		Search LifeMap BioReagents cell lines for MICAL1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MICAL1

Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003779	actin binding	IDA	--
GO:0004497	monooxygenase activity	--	--
GO:0005515	protein binding	IPI	11827972
GO:0008270	zinc ion binding	IEA	--
GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	IDA	--

MICAL1 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for MICAL1:

Synthetic lethal with Ras

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for MICAL1

STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

5/20 Interacting proteins for MICAL1 (Q8TDZ2^{2, 3} ENSP00000351664⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 20)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
GADD45A	P24522²^,³	MINT-8255934 I2D: score=2
GSK3B	P49841²^,³	MINT-8257471 I2D: score=2
PIK3R3	Q92569²^,³	MINT-8266282 I2D: score=2
RPS6KA6	Q9UK32²^,³	MINT-8269879 I2D: score=2
TAB1	Q15750²^,³	MINT-8260196 I2D: score=2

About this table

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001933	negative regulation of protein phosphorylation	IEA	--
GO:0007010	cytoskeleton organization	NAS	11827972
GO:0007165	signal transduction	NAS	11827972
GO:0030042	actin filament depolymerization	IDA	--
GO:0043066	negative regulation of apoptotic process	IEA	--

MICAL1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for MICAL1

1 HMDB Compound for MICAL1 About this table

Compound	Synonyms	CAS #	PubMed Ids
FAD	1H-Purin-6-amine flavin dinucleotide (see all 21)	146-14-5	--

Search CenterWatch for drugs/clinical trials and news about MICAL1 / MICA1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MICAL1 gene (2 alternative transcripts):

NM_001159291.1 NM_022765.3

Unigene Cluster for MICAL1:

Microtubule associated monoxygenase, calponin and LIM domain containing 1

Hs.33476 [show with all ESTs]

Unigene Representative Sequence: AK024500

8 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000456101 ENST00000358807(uc003ptj.3 uc003ptk.3 uc010kdr.3)

ENST00000465904 ENST00000433205 ENST00000483856 ENST00000431946 ENST00000368952(uc011eaq.2)

ENST00000358577

miRNA Products:		OriGene 3'-UTR Clone (see all 2): MICAL1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MICAL1
		5 QIAGEN miScript miRNA Assays for microRNAs that regulate MICAL1:
		hsa-miR-30c hsa-miR-30a hsa-miR-30b hsa-miR-30d hsa-miR-30e
		SwitchGear 3'UTR luciferase reporter plasmid: MICAL1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MICAL1 (see all 7) OriGene shRNA RFP: MICAL1 OriGene siRNA: MICAL1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MICAL1

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MICAL1 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MICAL1 (see all 4) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): MICAL1 (NM_022765)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MICAL1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MICAL1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MICAL1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat MICAL1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MICAL1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MICAL1

Additional cDNA sequence:

AB048948.1 AK021999.1 AK024500.1 AK025392.1 AK225049.1 AK296284.1 AL122098.1 BC009972.2

BC036514.1 BC042144.1 BC052983.1

20 DOTS entries:

DT.87017266 DT.95274656 DT.92456736 DT.100818386 DT.97769804 DT.100835424 DT.92456723 DT.95274660

DT.100818390 DT.95274657 DT.100818382 DT.99998086 DT.100829875 DT.102827435 DT.121341265 DT.121341268

DT.100810466 DT.100830290 DT.121341235 DT.91662419

24/205 AceView cDNA sequences (see all 205):

CF619327 AI805253 BX283101 BM054765 BM773327 AI523970 BQ707133 AU120376

AK160384 BM511745 BQ876555 AA502585 BG764163 BC052983 BF908155 AU125837

CA432275 AI003936 AI143323 BU732130 AI673370 BM068780 CD300619 BM702005

GeneLoc Exon Structure

5/23 Alternative Splicing Database (ASD) splice patterns (SP) for MICAL1 (see all 23) About this scheme

ExUns:	1	^	2a	·	2b	^	3a	·	3b	·	3c	·	3d	^	4a	·	4b	·	4c	·	4d	^	5a	·	5b	·	5c	^	6a	·	6b	·	6c	·	6d	^	7a	·	7b	·	7c	·	7d	^	8a	·	8b	^	9	^	10	^
SP1:							-		-		-		-		-		-		-		-		-		-		-		-
SP2:															-		-		-		-		-						-
SP3:
SP4:
SP5:

ExUns:	11	^	12a	·	12b	^	13a	·	13b	·	13c	^	14a	·	14b	^	15	^	16a	·	16b	·	16c	^	17a	·	17b	·	17c	·	17d	^	18	^	19a	·	19b	^	20	^	21a	·	21b	^	22	^	23a	·	23b	^	24a	·
SP1:	-						-								-								-		-																								-
SP2:							-								-								-		-																								-		-
SP3:	-						-		-		-				-								-		-																								-
SP4:							-								-				-						-		-																						-
SP5:																																																	-

ExUns:	24b	^	25a	·	25b	·	25c	^	26a	·	26b	^	27	^	28a	·	28b	^	29	^	30a	·	30b	^	31
SP1:			-		-												-				-
SP2:			-		-												-				-
SP3:			-		-												-				-
SP4:			-		-												-				-
SP5:

ECgene alternative splicing isoforms for MICAL1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MICAL1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AACCGGGAAG

About this image
See MICAL1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MICAL1

SOURCE GeneReport for Unigene cluster: Hs.33476

UniProtKB/Swiss-Prot: MICA1_HUMAN, Q8TDZ2

Tissue specificity: Expressed in the thymus, lung, spleen, kidney, testis and hematopoietic cells

SABiosciences Custom PCR Arrays for MICAL1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MICAL1 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MICAL1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MICAL1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MICAL1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for MICAL1 gene from 4/16 species (see all 16) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Mical1^{1 , 5}	microtubule associated monoxygenase, calponin and LIM more^{1, 5}	82.87(n)¹ 82.13(a)¹		10 (22.41 cM)⁵ 171580¹ NM_138315.2¹ NP_612188.1¹ 41476314⁵
chicken (Gallus gallus)	Aves	MICAL1¹	microtubule associated monoxygenase, calponin and LIM more	63.97(n) 58.05(a)		429474 NM_001031576.1 NP_001026747.1
zebrafish (Danio rerio)	Actinopterygii	si:ch211-59c24.3⁶ mical1⁶	si:ch211-59c24.3 microtubule associated monoxygenase, calponin and ...	8(a) 38(a)	possible ortholog 1 ↔ 1	18(10333032-10369976) 23(39607730-39680259)
fruit fly (Drosophila melanogaster)	Insecta	Mical⁶	Molecule interacting with CasL	7(a)	1 → many	3R(5827276-5868617)

ENSEMBL Gene Tree for MICAL1 (if available)
TreeFam Gene Tree for MICAL1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for MICAL1 gene

MICALL2² MICALL1² MICAL2² MICALCL² EHBP1² MICAL3² EHBP1L1²

3 SIMAP similar genes for MICAL1 using alignment to 5 protein entries: MICA1_HUMAN (see all proteins):

MICAL2 DMD MICAL3

MICAL1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs189234851^1,2		--	109765624(+)	`ATGTGA/GTTTCT`	2	--	int¹		0	--	--	--	--
rs191414627^1,2		--	109765761(+)	`CTGATG/TGAACT`	2	--	int¹		0	--	--	--	--
rs2146411^1,2	C,	--	109765788(+)	`TTGGAG/CCCCCC`	2	--	int¹		5		EA CSA WA NA	1270
rs111775757^1,2	C,	--	109765810(+)	`CCTCCT/CGAATT`	2	--	int¹		1		NA	120
rs2236582^1,2	C,F,O,H,	--	109765818(-)	`TCTGAG/CACAAT`	2	--	int¹		28		EA NA NS WA CSA	4327
rs183700603^1,2		--	109765840(+)	`TAGAGC/TATCAT`	2	--	int¹		0	--	--	--	--
rs61303854^1,2	C,	--	109765870(+)	`AGATCA/GTGAGG`	2	--	int¹		3		WA CSA	122
rs77804703^1,2		--	109765871(+)	`GATCAC/TGAGGC`	2	--	int¹		0	--	--	--	--
rs143888193^1,2	C,	--	109765883(+)	`TGCATC/GACACA`	2	--	int¹		0	--	--	--	--
rs200636139^1,2		--	109765933(+)	`CTTCCC/TGGTTC`	4	Q R	mis¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for MICAL1 (109765265 - 109787171 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MICAL1: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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MICAL1 for disorders           About GeneDecksing

OMIM gene information: 607129    OMIM disorders: --

1 disease for MICAL1:    About MalaCards

anthracosilicosis

Human Genome Epidemiology (HuGE) Navigator: MICAL1 (4 documents)

Export disorders for MICAL1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for MICAL1 gene, integrated from 9 sources (see all 32):
(articles sorted by number of sources associating them with MICAL1)

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MICAL, a novel CasL interacting molecule, associates with vimentin. (PubMed id 11827972)^{1, 2, 3} Suzuki T.... Hirai H. (2002)
Investigation of the four cooperative unfolding units existing in the MICAL-1 CH domain. (PubMed id 17662518)^{1, 2} Jin X....Shi Y. (2007)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (2006)
The MICAL proteins and rab1: a possible link to the cytoskeleton? (PubMed id 15694364)^{1, 2} Fischer J.... Barnekow A. (2005)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
MICAL-1 isoforms, novel rab1 interacting proteins. (PubMed id 12788069)^{1, 2} Weide T....Barnekow A. (2003)
The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)^{1, 2} Mungall A.J.... Beck S. (2003)
MICALs, a family of conserved flavoprotein oxidoreductases, function in plexin-mediated axonal repulsion. (PubMed id 12110185)^{1, 2} Terman J.R.... Kolodkin A.L. (2002)
Characterization of long cDNA clones from human adult spleen. (PubMed id 11214971)^{1, 2} Hattori A.... Ohara O. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 64780	HGNC: 20619	AceView: NICAL	Ensembl:ENSG00000135596	euGenes: HUgn64780
ECgene: MICAL1	H-InvDB: MICAL1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for MICAL1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for MICAL1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for MICAL1 gene:
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GeneCards and IP:
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