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Aliases for MICA Gene

Aliases for MICA Gene

  • MHC Class I Polypeptide-Related Sequence A 2 3 5
  • PERB11.1 3 4
  • MIC-A 3 4
  • Truncated MHC Class I Polypeptide-Related Sequence A 3
  • MHC Class I Chain-Related Protein A 3
  • Stress Inducible Class I Homolog 3
  • MHC Class I Related Sequence A 3
  • MHC Class I Related Chain A 3
  • HLA Class I Antigen 3

External Ids for MICA Gene

Previous GeneCards Identifiers for MICA Gene

  • GC06P031425
  • GC06P031140
  • GC06P031471
  • GC06P031475
  • GC06P031479
  • GC06Pf31500
  • GC06Pc31510
  • GC06P031371
  • GC06P031370
  • GC06P031373

Summaries for MICA Gene

Entrez Gene Summary for MICA Gene

  • This gene encodes the highly polymorphic major histocompatability complex class I chain-related protein A. The protein product is expressed on the cell surface, although unlike canonical class I molecules it does not seem to associate with beta-2-microglobulin. It is a ligand for the NKG2-D type II integral membrane protein receptor. The protein functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells. Variations in this gene have been associated with susceptibility to psoriasis 1 and psoriatic arthritis, and the shedding of MICA-related antibodies and ligands is involved in the progression from monoclonal gammopathy of undetermined significance to multiple myeloma. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2014]

GeneCards Summary for MICA Gene

MICA (MHC Class I Polypeptide-Related Sequence A) is a Protein Coding gene. Diseases associated with MICA include Spondylitis and Psoriatic Arthritis. Among its related pathways are Immune response Role of DAP12 receptors in NK cells and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include antigen binding and natural killer cell lectin-like receptor binding. An important paralog of this gene is MICB.

UniProtKB/Swiss-Prot for MICA Gene

  • Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T-cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis.

Additional gene information for MICA Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MICA Gene

Genomics for MICA Gene

Regulatory Elements for MICA Gene

Enhancers for MICA Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06H031538 1.4 ENCODE dbSUPER 38.3 +141.4 141355 4.9 MLX ZFP64 FEZF1 DMAP1 YY1 ZNF143 SP3 MCM3 PPARGC1A MEF2D ATF6B LSM2 LY6G5B DDX39B MDC1 PPP1R10 NRM DHX16 MSH5 TCF19
GH06H031353 1.7 FANTOM5 Ensembl ENCODE dbSUPER 24.7 -43.6 -43593 7 HDGF PKNOX1 ATF1 NSD2 ZNF2 GLIS2 ZNF143 ZNF207 FOS RUNX3 HLA-C HLA-B DDX39B ENSG00000271581 MICA LY6G5B ATF6B RPL7P4 MICA-AS1 SKIV2L
GH06H031567 2 FANTOM5 Ensembl ENCODE dbSUPER 20.3 +178.6 178635 22.2 HDGF PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 YBX1 ZNF2 ZBTB7B TNF DDX39B LY6G5B ATF6B LSM2 TCF19 MDC1 DHX16 NFKBIL1 C6orf47
GH06H031545 1.2 ENCODE 33.5 +147.7 147749 3.2 MLX YBX1 FEZF1 DMAP1 YY1 ZNF143 SP3 NFYC ZC3H11A MEF2D DDX39B LSM2 LY6G5B ATF6B DHX16 MDC1 NRM TCF19 NFKBIL1 MICA
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MICA on UCSC Golden Path with GeneCards custom track

Promoters for MICA Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Locations for MICA Gene

Genomic Locations for MICA Gene
15,532 bases
Plus strand

Genomic View for MICA Gene

Genes around MICA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MICA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MICA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for MICA Gene

  • Protein details for MICA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    MHC class I polypeptide-related sequence A
    Protein Accession:
    Secondary Accessions:
    • A8KQR0
    • A9LRW5
    • A9QVE0
    • B1VJF1
    • O60917
    • O60918
    • O60919
    • O60920
    • O60933
    • O77956
    • O78150
    • O78151
    • O78152
    • O78153
    • O97987
    • O97988
    • O97989
    • O97990
    • O97991
    • O97992
    • O97993
    • O97994
    • O97995
    • O98234
    • O98235
    • O98236
    • O98237
    • O98238
    • P79506
    • P79507
    • P79508
    • P79509
    • P79510
    • P79511
    • P79512
    • P79513
    • P79514
    • P79515
    • P79516
    • P79517
    • P79518
    • P79519
    • P79520
    • P79521
    • Q5C9P8
    • Q5XM81
    • Q70I48
    • Q70I49
    • Q7JFH9
    • Q7JFI0
    • Q7JFI1
    • Q7JFI2
    • Q7YQ98
    • Q861I1
    • Q95464
    • Q95HA2
    • Q95HD6
    • Q95HN4
    • Q95HN5
    • Q95HN6
    • Q95IB2
    • Q95IY7
    • Q99692
    • Q9BCR3
    • Q9BCR4
    • Q9BCR5
    • Q9BCR6
    • Q9BCR7
    • Q9BCR8
    • Q9BCR9
    • Q9BCS0
    • Q9BCS1
    • Q9BCS2
    • Q9BCS3
    • Q9BCS4
    • Q9BD20
    • Q9GIZ1
    • Q9GIZ2
    • Q9GIZ3
    • Q9GIZ4
    • Q9GIZ5
    • Q9GIZ6
    • Q9GJ01
    • Q9GJ02
    • Q9GJ03
    • Q9GJ04
    • Q9GJ05
    • Q9GJ06
    • Q9GJ07
    • Q9GJ08
    • Q9GJ09
    • Q9MY21
    • Q9TQ86
    • Q9TQ87
    • Q9TQ88
    • Q9TQ89
    • Q9TQ92
    • Q9TQ93
    • Q9TQ94
    • Q9TQ95
    • Q9TQ96
    • Q9TQ97
    • Q9TQ98
    • Q9TQ99
    • Q9TQA0
    • Q9TQA1
    • Q9TQA2
    • Q9TQA3
    • Q9TQA4
    • Q9TQI9
    • Q9TQJ0
    • Q9TQJ1
    • Q9TQJ9
    • Q9TQK0
    • Q9TQK1
    • Q9TQK2
    • Q9TQK8
    • Q9TQK9
    • Q9TQL0
    • Q9TQL1
    • Q9TQL2
    • Q9TQL3
    • Q9TQL4
    • Q9UE04
    • Q9UE05
    • Q9UE06
    • Q9UE11

    Protein attributes for MICA Gene

    383 amino acids
    Molecular mass:
    42915 Da
    Quaternary structure:
    • Unlike classical MHC class I molecules, does not form a heterodimer with beta-2-microglobulin. Binds as a monomer to a KLRK1/NKG2D homodimer. KLRK1 forms a complex with HCST/DAP10 in which KLRK1 binds MICA while HCST acts as an adapter molecule which enables signal transduction. Interacts with PDIA6 on the surface of tumor cells, leading to disulfide bond reduction which is required for release of MICA from tumor cells. Interacts with human cytomegalovirus/HHV-5 protein UL142.
    • Recognized by antibodies in the sera of some organ transplant recipients and may be a target molecule in allograft rejection.

    Three dimensional structures from OCA and Proteopedia for MICA Gene

    Alternative splice isoforms for MICA Gene


neXtProt entry for MICA Gene

Post-translational modifications for MICA Gene

  • N-glycosylated. Glycosylation is not essential for interaction with KLRK1/NKG2D but enhances complex formation.
  • Proteolytically cleaved and released from the cell surface of tumor cells which impairs KLRK1/NKG2D expression and T-cell activation.
  • Glycosylation at Asn31, Asn79, Asn125, posLast=210210, posLast=220220, and posLast=261261
  • Modification sites at PhosphoSitePlus

Other Protein References for MICA Gene

No data available for DME Specific Peptides for MICA Gene

Domains & Families for MICA Gene

Gene Families for MICA Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the MHC class I family. MIC subfamily.
  • Belongs to the MHC class I family. MIC subfamily.
genes like me logo Genes that share domains with MICA: view

Function for MICA Gene

Molecular function for MICA Gene

GENATLAS Biochemistry:
MHC class I,chain-related gene A,43kDa,preferentially expressed in fibroblast and epithelial cell,with a repeat polymorphism in TM region possibly associated with Behcet disease,not involved in ankylosing spondylitis
UniProtKB/Swiss-Prot Function:
Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T-cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis.
UniProtKB/Swiss-Prot Induction:
By heat shock, by infection with human cytomegalovirus (HCMV), human adenovirus 5, M.tuberculosis and diarrheagenic E.coli, and by exposure to DNA damaging conditions such as high doses of ionizing radiation, chromatin-modifying treatments and inhibitors of DNA replication. The HCMV UL142 protein causes down-regulation of the full-length protein but not of the truncated MICA*008 allele.

Phenotypes From GWAS Catalog for MICA Gene

Gene Ontology (GO) - Molecular Function for MICA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11323699
GO:0030881 NOT beta-2-microglobulin binding IDA 8901601
GO:0046703 natural killer cell lectin-like receptor binding IPI 10426993
genes like me logo Genes that share ontologies with MICA: view
genes like me logo Genes that share phenotypes with MICA: view

Animal Model Products

miRNA for MICA Gene

miRTarBase miRNAs that target MICA

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MICA Gene

Localization for MICA Gene

Subcellular locations from UniProtKB/Swiss-Prot for MICA Gene

Cell membrane; Single-pass type I membrane protein. Cytoplasm. Note=Expressed on the cell surface in gastric epithelium, endothelial cells and fibroblasts and in the cytoplasm in keratinocytes and monocytes. Infection with human adenovirus 5 suppresses cell surface expression due to the adenoviral E3-19K protein which causes retention in the endoplasmic reticulum. {ECO:0000269 PubMed:10363723, ECO:0000269 PubMed:18287244, ECO:0000269 PubMed:8901601}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MICA gene
Compartment Confidence
plasma membrane 3
extracellular 2
nucleus 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for MICA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 18676862
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IDA 18676862
GO:0009986 cell surface IDA 8901601
genes like me logo Genes that share ontologies with MICA: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MICA Gene

Pathways & Interactions for MICA Gene

genes like me logo Genes that share pathways with MICA: view

Interacting Proteins for MICA Gene

Selected Interacting proteins: Q29983-MICA_HUMAN for MICA Gene via IID UniProtKB MINT

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for MICA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001913 T cell mediated cytotoxicity IDA 10426993
GO:0002418 immune response to tumor cell IDA 10359807
GO:0006974 cellular response to DNA damage stimulus IDA 15995699
GO:0009408 response to heat IDA 8901601
GO:0016032 viral process IEA --
genes like me logo Genes that share ontologies with MICA: view

No data available for SIGNOR curated interactions for MICA Gene

Drugs & Compounds for MICA Gene

No Compound Related Data Available

Transcripts for MICA Gene

mRNA/cDNA for MICA Gene

(5) REFSEQ mRNAs :
(12) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MICA Gene

MHC class I polypeptide-related sequence A:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MICA Gene

No ASD Table

Relevant External Links for MICA Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MICA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MICA Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MICA Gene

NURSA nuclear receptor signaling pathways regulating expression of MICA Gene:


SOURCE GeneReport for Unigene cluster for MICA Gene:


mRNA Expression by UniProt/SwissProt for MICA Gene:

Tissue specificity: Widely expressed with the exception of the central nervous system where it is absent. Expressed predominantly in gastric epithelium and also in monocytes, keratinocytes, endothelial cells, fibroblasts and in the outer layer of Hassals corpuscles within the medulla of normal thymus. In skin, expressed mainly in the keratin layers, basal cells, ducts and follicles. Also expressed in many, but not all, epithelial tumors of lung, breast, kidney, ovary, prostate and colon. In thyomas, overexpressed in cortical and medullar epithelial cells. Tumors expressing MICA display increased levels of gamma delta T-cells.

Evidence on tissue expression from TISSUES for MICA Gene

  • Blood(2.6)
genes like me logo Genes that share expression patterns with MICA: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for MICA Gene

Orthologs for MICA Gene

This gene was present in the common ancestor of chordates.

Orthologs for MICA Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MICB 34
  • 73 (a)
(Bos Taurus)
Mammalia -- 34
  • 37 (a)
(Monodelphis domestica)
Mammalia MILL-LIKE 34
  • 26 (a)
(Mus musculus)
Mammalia Mill1 34
  • 26 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 18 (a)
(Gallus gallus)
Aves -- 34
  • 28 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 22 (a)
(Danio rerio)
Actinopterygii si:ch211-147g22.4 34
  • 23 (a)
BX572619.3 34
  • 20 (a)
mhc1uba 34
  • 20 (a)
mhc1zca 34
  • 20 (a)
mhc1zea 34
  • 20 (a)
si:ch211-147g22.1 34
  • 20 (a)
CR339041.1 34
  • 19 (a)
mhc1uca 34
  • 19 (a)
si:dkey-52p2.7 34
  • 19 (a)
BX572619.1 34
  • 18 (a)
BX572619.2 34
  • 18 (a)
BX682558.1 34
  • 18 (a)
CU571323.1 34
  • 18 (a)
mhc1zfa 34
  • 18 (a)
si:ch211-147g22.3 34
  • 18 (a)
si:dkey-52p2.6 34
  • 18 (a)
CABZ01031753.1 34
  • 17 (a)
DARE-ZE*0601 34
  • 17 (a)
mhc1zaa 34 34
  • 17 (a)
mhc1zba 34
  • 17 (a)
si:ch211-147g22.2 34
  • 17 (a)
arpc1a 34
  • 16 (a)
CR339041.2 34
  • 16 (a)
si:dkey-52p2.4 34
  • 16 (a)
CABZ01031754.1 34
  • 15 (a)
zgc:113060 34
  • 15 (a)
Species where no ortholog for MICA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MICA Gene

Gene Tree for MICA (if available)
Gene Tree for MICA (if available)

Paralogs for MICA Gene

Paralogs for MICA Gene

genes like me logo Genes that share paralogs with MICA: view

Variants for MICA Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for MICA Gene

The following alleles of MICA are known: MICA*001, MICA*002, MICA*004, MICA*005, MICA*006, MICA*007, MICA*008, MICA*009, MICA*010, MICA*011, MICA*012, MICA*013, MICA*014, MICA*015, MICA*016, MICA*017, MICA*018, MICA*019, MICA*020, MICA*022, MICA*023, MICA*024, MICA*025, MICA*026, MICA*027, MICA*028, MICA*029, MICA*030, MICA*031, MICA*032, MICA*033, MICA*034, MICA*035, MICA*036, MICA*037, MICA*038, MICA*039, MICA*040, MICA*041, MICA*042, MICA*043, MICA*044, MICA*045, MICA*046, MICA*047, MICA*048, MICA*049, MICA*050, MICA*051, MICA*052, MICA*053, MICA*054, MICA*055 and MICA*056. The sequence shown is that of MICA*001.

Sequence variations from dbSNP and Humsavar for MICA Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs41540613 Benign 31,412,063(+) ATGGG(C/G)TATCT reference, missense
rs1000359507 -- 31,399,954(+) GGCGG(A/G)CGCTG nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000911754 -- 31,398,009(+) AGCTT(C/G)GAGTA intron-variant, upstream-variant-2KB
rs1001009814 -- 31,410,580(+) CTGTC(C/T)TGGGA reference, synonymous-codon, utr-variant-5-prime
rs1001126437 -- 31,403,706(+) TGGTG(A/G)GTGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MICA Gene

Variant ID Type Subtype PubMed ID
nsv970363 CNV duplication 23825009
nsv965706 CNV duplication 23825009
nsv823497 CNV loss 20364138
nsv818409 CNV loss 17921354
nsv601923 CNV loss 21841781
nsv601922 CNV loss 21841781
nsv601880 CNV gain+loss 21841781
nsv601608 CNV loss 21841781
nsv517441 CNV gain+loss 19592680
nsv513736 CNV insertion 21212237
nsv511868 CNV loss 21212237
nsv509125 CNV insertion 20534489
nsv462854 CNV gain 19166990
nsv441990 CNV loss 18776908
nsv437496 CNV loss 16327808
nsv435829 CNV deletion 17901297
nsv428140 CNV gain+loss 18775914
nsv1161369 CNV deletion 26073780
nsv1144139 CNV deletion 24896259
nsv1112899 CNV deletion 24896259
nsv10820 CNV gain+loss 18304495
nsv1074389 CNV deletion 25765185
nsv1030802 CNV gain 25217958
nsv1022499 CNV gain 25217958
esv3890820 CNV loss 25118596
esv3890819 CNV loss 25118596
esv3608561 CNV loss