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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MICA Gene

protein-coding   GIFtS: 60
GCID: GC06P031373

MHC Class I Polypeptide-Related Sequence A

Pneumococci & Pneumococcal Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 11.2

Aliases
MHC Class I Polypeptide-Related Sequence A1 2
MIC-A2 3
PERB11.12 3
HLA Class I Antigen2
MHC Class I Chain-Related Protein A2
Stress Inducible Class I Homolog2

External Ids:    HGNC: 70901   Entrez Gene: 1005074362   Ensembl: ENSG000002045207   OMIM: 6001695   UniProtKB: Q299833   
ORGUL members:    fRNAdb10:FR352832 FR236338 FR336776 FR233833 FR240956      
NCBI13:AY927511 AY927513 AY927512    
NONCODE14:n410085 n377595 n410086 n410090 n410091 see all 101      
RNAdb15:EVF18429 LIT3521 ASO3547 LIT3523 LIT3522 see all 8    

Export aliases for MICA gene to outside databases

Previous GC identifers: GC06P031425 GC06P031140 GC06P031471 GC06P031475 GC06P031479 GC06Pf31500 GC06Pc31510 GC06P031371 GC06P031370


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MICA Gene:
MICA encodes the higly polymorphic MHC (HLA) class I chain-related gene A. The protein product is expressed on the
cell surface, although unlike canonical class I molecules does not seem to associate with beta-2-microglobulin.
It is thought that MICA functions as a stress-induced antigen that is broadly recognized by intestinal epithelial
gamma delta T cells. Alternative splicing results in multiple transcript variants. (provided by RefSeq, Nov 2010)

GeneCards Summary for MICA Gene: 
MICA (MHC class I polypeptide-related sequence A) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with MICA include hiv-1 viremia, and histoplasmosis, and among its related super-pathways are Immune System and Immune response Role of DAP12 receptors in NK cells. GO annotations related to this gene include natural killer cell lectin-like receptor binding and beta-2-microglobulin binding. An important paralog of this gene is MICB.

UniProtKB/Swiss-Prot: MICA_HUMAN, Q29983
Function: Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized
by gamma delta T-cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis



fRNAdb sequence ontologies for MICA - the ORGUL cluster for this gene includes several descriptions:
nc_conserved_region - Non-coding region of sequence similarity by descent from a common ancestor.
antisense_RNA - Antisense RNA is RNA that is transcribed from the coding, rather than the template, strand of DNA. It is therefore complementary to mRNA.
mature_transcript - A transcript which has undergone the necessary modifications, if any, for its function. In eukaryotes this includes, for example, processing of introns, cleavage, base modification, and modifications to the 5' and/or the 3' ends, other than addition of bases. In bacteria functional mRNAs are usually not modified.

View fRNAdb secondary structures for MICA

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.2  NT_007592.15  NT_113891.2  NT_167249.1  NT_167246.1  NT_167248.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MICA gene promoter:
         c-Fos   Sp1   AP-1   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMICA promoter sequence
   Search SABiosciences Chromatin IP Primers for MICA

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MICA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.33   Ensembl cytogenetic band:  6p21.33   HGNC cytogenetic band: 6p21.3

MICA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MICA gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P031373:  view genomic region     (about GC identifiers)

Start:
31,367,561 bp from pter      End:
31,383,092 bp from pter
Size:
15,532 bases      Orientation:
plus strand

4 alternative locations:
Chr6+,NT_167249 2,702,271-2,716,888      Chr6+,NT_113891.2 2,881,169-2,895,790      Chr6+,NT_167246 2,717,805-2,729,520     
Chr6+,NT_167248 2,664,817-2,676,634     
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for MICA

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MICA_HUMAN, Q29983 (See protein sequence)
Recommended Name: MHC class I polypeptide-related sequence A precursor  
Size: 383 amino acids; 42915 Da
Subunit: Unlike classical MHC class I molecules, does not form a heterodimer with beta-2-microglobulin. Binds as a
monomer to a KLRK1/NKG2D homodimer. KLRK1 forms a complex with HCST/DAP10 in which KLRK1 binds MICA while HCST
acts as an adapter molecule which enables signal transduction. Interacts with PDIA6 on the surface of tumor
cells, leading to disulfide bond reduction which is required for release of MICA from tumor cells. Interacts with
human cytomegalovirus/HHV-5 protein UL142
Subcellular location: Cell membrane; Single-pass type I membrane protein. Cytoplasm. Note=Expressed on the cell
surface in gastric epithelium, endothelial cells and fibroblasts and in the cytoplasm in keratinocytes and
monocytes. Infection with human adenovirus 5 suppresses cell surface expression due to the adenoviral E3-19K
protein which causes retention in the endoplasmic reticulum
Miscellaneous: Recognized by antibodies in the sera of some organ transplant recipients and may be a target
molecule in allograft rejection
2 PDB 3D structures from and Proteopedia for MICA:
1B3J (3D)        1HYR (3D)    
Secondary accessions: A8KQR0 A9LRW5 A9QVE0 B1VJF1 O60917 O60918 O60919 O60920 O60933 O77956
O78150 O78151 O78152 O78153 O97987 O97988 O97989 O97990 O97991 O97992 O97993 O97994 O97995
O98234 O98235 O98236 O98237 O98238 P79506 P79507 P79508 P79509 P79510 P79511 P79512 P79513
P79514 P79515 P79516 P79517 P79518 P79519 P79520 P79521 Q5C9P8 Q5XM81 Q70I48 Q70I49 Q7JFH9
Q7JFI0 Q7JFI1 Q7JFI2 Q7YQ98 Q861I1 Q95464 Q95HA2 Q95HD6 Q95HN4 Q95HN5 Q95HN6 Q95IB2 Q95IY7
Q99692 Q9BCR3 Q9BCR4 Q9BCR5 Q9BCR6 Q9BCR7 Q9BCR8 Q9BCR9 Q9BCS0 Q9BCS1 Q9BCS2 Q9BCS3 Q9BCS4
Q9BD20 Q9GIZ1 Q9GIZ2 Q9GIZ3 Q9GIZ4 Q9GIZ5 Q9GIZ6 Q9GJ01 Q9GJ02 Q9GJ03 Q9GJ04 Q9GJ05 Q9GJ06
Q9GJ07 Q9GJ08 Q9GJ09 Q9MY21 Q9TQ86 Q9TQ87 Q9TQ88 Q9TQ89 Q9TQ92 Q9TQ93 Q9TQ94 Q9TQ95 Q9TQ96
Q9TQ97 Q9TQ98 Q9TQ99 Q9TQA0 Q9TQA1 Q9TQA2 Q9TQA3 Q9TQA4 Q9TQI9 Q9TQJ0 Q9TQJ1 Q9TQJ9 Q9TQK0
Q9TQK1 Q9TQK2 Q9TQK8 Q9TQK9 Q9TQL0 Q9TQL1 Q9TQL2 Q9TQL3 Q9TQL4 Q9UE04 Q9UE05 Q9UE06 Q9UE11
Alternative splicing: 2 isoforms:  Q29983-1   Q29983-2   

Explore the universe of human proteins at neXtProt for MICA: NX_Q29983

Explore proteomics data for MICA at MOPED 

Post-translational modifications:

  • UniProtKB: N-glycosylated. Glycosylation is not essential for interaction with KLRK1/NKG2D but enhances complex formation
  • UniProtKB: Proteolytically cleaved and released from the cell surface of tumor cells which impairs KLRK1/NKG2D expression and
    T-cell activation
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q29983

  • MICA Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MICA Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_000238.1  NP_001170990.1  

    ENSEMBL proteins: 
     ENSP00000413079   ENSP00000402410  

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    Cloud-Clone Corp. Proteins for MICA 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IDA18676862
    GO:0005737cytoplasm IEA--
    GO:0005887integral to plasma membrane IDA18676862
    GO:0009986cell surface IDA18676862
    GO:0042612MHC class I protein complex ----

    MICA for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    C1SET: Immunoglobulin superfamily / C1-set domain containing

    5/6 InterPro protein domains (see all 6):
     IPR011162 MHC_I/II-like_Ag-recog
     IPR013783 Ig-like_fold
     IPR003597 Ig_C1-set
     IPR007110 Ig-like_dom
     IPR011161 MHC_I-like_Ag-recog

    Graphical View of Domain Structure for InterPro Entry Q29983

    ProtoNet protein and cluster: Q29983

    1 Blocks protein domain: IPB003597 Immunoglobulin C-type

    UniProtKB/Swiss-Prot: MICA_HUMAN, Q29983
    Similarity: Belongs to the MHC class I family. MIC subfamily
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain


    MICA for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MICA_HUMAN, Q29983
    Function: Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized
    by gamma delta T-cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis
    Induction: By heat shock, by infection with human cytomegalovirus (HCMV), human adenovirus 5, M.tuberculosis and
    diarrheagenic E.coli, and by exposure to DNA damaging conditions such as high doses of ionizing radiation,
    chromatin-modifying treatments and inhibitors of DNA replication. The HCMV UL142 protein causes down-regulation
    of the full-length protein but not of the truncated MICA*008 allele

         Genatlas biochemistry entry for MICA:
    MHC class I,chain-related gene A,43kDa,preferentially expressed in fibroblast and epithelial cell,with a repeat
    polymorphism in TM region possibly associated with Behcet disease,not involved in ankylosing spondylitis

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003823antigen binding IBA--
    GO:0005515protein binding IPI11323699
    GO:0030881NOT beta-2-microglobulin binding IDA8901601
    GO:0046703natural killer cell lectin-like receptor binding IPI10426993
         
    MICA for ontologies           About GeneDecksing


    Animal Models:
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    miRNA
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    miRTarBase miRNAs that target MICA:
    hsa-mir-373 (MIRT002551), hsa-mir-520b (MIRT004677)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MICA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MICA About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Immune System
    Immune System0.56
    Adaptive Immune System0.56
    2Immune response Fc epsilon RI pathway
    Natural killer cell mediated cytotoxicity0.31
    3Classical antibody-mediated complement activation
    Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell0.30

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    1         Kegg Pathway  (Kegg details for MICA):
        Natural killer cell mediated cytotoxicity


    MICA for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MICA

    3 Interacting proteins for MICA (Q299832, 3) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LGALS3P179312, 3MINT-8214455 MINT-8214577 I2D: score=1 
    KLRK1P267182, 3MINT-8214603 I2D: score=4 
    KLRC4O439083I2D: score=1 
    About this table

    Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001913T cell mediated cytotoxicity IDA10426993
    GO:0002418immune response to tumor cell IDA10359807
    GO:0006955immune response ----
    GO:0006974response to DNA damage stimulus IDA15995699
    GO:0009408response to heat IDA8901601

    MICA for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for MICA

    Search CenterWatch for drugs/clinical trials and news about MICA

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section
    5 fRNAdb Secondary structures:


    REFSEQ mRNAs for MICA gene (2 alternative transcripts): 
    NM_000247.1  NM_001177519.1  

    Unigene Cluster for MICA:

    MHC class I polypeptide-related sequence A
    Hs.130838  [show with all ESTs]
    Unigene Representative Sequence: NR_036523
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000449934(uc003ntk.1) ENST00000421350

    miRNA
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    Additional mRNA sequence: 

    AB506764.1 AK094237.1 AK225393.1 AK299135.1 AK310028.1 AK311667.1 AY204547.1 AY750850.1 
    BC016929.1 L14848.1 NR_036523.1 NR_036524.1 

    20 DOTS entries:

    DT.121310192  DT.97798115  DT.100813116  DT.121310373  DT.413253  DT.100813115  DT.40210949  DT.100837934 
    DT.121310691  DT.121310550  DT.121310518  DT.95280037  DT.121310783  DT.100773245  DT.408185  DT.92003125 
    DT.95085360  DT.92434498  DT.91911313  DT.97844162 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MICA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTCTGCTGT
    MICA Expression
    About this image


    See MICA Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MICA

    SOURCE GeneReport for Unigene cluster: Hs.130838

    UniProtKB/Swiss-Prot: MICA_HUMAN, Q29983
    Tissue specificity: Widely expressed with the exception of the central nervous system where it is absent.
    Expressed predominantly in gastric epithelium and also in monocytes, keratinocytes, endothelial cells,
    fibroblasts and in the outer layer of Hassal's corpuscles within the medulla of normal thymus. In skin, expressed
    mainly in the keratin layers, basal cells, ducts and follicles. Also expressed in many, but not all, epithelial
    tumors of lung, breast, kidney, ovary, prostate and colon. In thyomas, overexpressed in cortical and medullar
    epithelial cells. Tumors expressing MICA display increased levels of gamma delta T-cells

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for MICA gene from 3/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves --
    --
    29(a)
    1 → many
    AADN03014659.1(517-1002)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    22(a)
    possible ortholog
    GL343777.1(59223-67524)
    zebrafish
    (Danio rerio)
    Actinopterygii BX682558.16
    BX572619.16
    (see all 11)
    Uncharacterized protein
    (see all 11)
    19(a)
    19(a)
    (see all 11)
    many ↔ many
    many ↔ many
    (see all 11)
    3(23762869-23765495)
    25(11082589-11085195)
            Species with no ortholog for MICA

    ENSEMBL Gene Tree for MICA (if available)
    TreeFam Gene Tree for MICA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MICA gene
    MICB2  AZGP12  
    18/91 SIMAP similar genes for MICA using alignment to 64 protein entries:     MICA_HUMAN (see all proteins) (see all similar genes):
    HLA-MICA    PERB11.1    MICB    DKFZp762B162    HLA-A*0201V3    PTPNS1
    HLA-G2.2    SIRPB1    Cw    CD1E    HFE    HLA-Cw*
    HLA C*    HLA-G    HLA-A*02    HLA-A24AK    MHC    HLA-B*

    MICA for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: MICA_HUMAN, Q29983
    Polymorphism: The following alleles of MICA are known: MICA*001, MICA*002, MICA*004, MICA*005, MICA*006, MICA*007,
    MICA*008, MICA*009, MICA*010, MICA*011, MICA*012, MICA*013, MICA*014, MICA*015, MICA*016, MICA*017, MICA*018,
    MICA*019, MICA*020, MICA*022, MICA*023, MICA*024, MICA*025, MICA*026, MICA*027, MICA*028, MICA*029, MICA*030,
    MICA*031, MICA*032, MICA*033, MICA*034, MICA*035, MICA*036, MICA*037, MICA*038, MICA*039, MICA*040, MICA*041,
    MICA*042, MICA*043, MICA*044, MICA*045, MICA*046, MICA*047, MICA*048, MICA*049, MICA*050, MICA*051, MICA*052,
    MICA*053, MICA*054, MICA*055 and MICA*056. The sequence shown is that of MICA*001


    10/737 SNPs in MICA are shown (see all 737)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0436524
    ----see VAR_0436522 S G mis40--------
    VAR_0436654
    ----see VAR_0436652 D A mis40--------
    VAR_0438694
    ----see VAR_0438692 W S mis40--------
    VAR_0436624
    ----see VAR_0436622 V I mis40--------
    VAR_0436644
    ----see VAR_0436642 T M mis40--------
    VAR_0436664
    ----see VAR_0436662 T A mis40--------
    VAR_0436674
    ----see VAR_0436672 A T mis40--------
    rs1158412461,2
    C,F--31173958(+) TTTTCA/GTAGAG 2 -- ds50011Minor allele frequency- G:0.04NA 120
    rs28445161,2
    C,F--31299173(-) TCCTGG/AGGCAG 1 -- int17Minor allele frequency- A:0.41WA NA CSA EA 365
    rs3688405631,2
    C--31299173(+) TGCCC-/TCAGGA 1 -- int10--------

    HapMap Linkage Disequilibrium report for MICA (31367561 - 31383092 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/38 variations for MICA (see all 38):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2432528CNV Deletion19546169
    esv2731822CNV Deletion23290073
    dgv1098e199CNV Deletion23128226
    nsv435829CNV Deletion17901297
    dgv1042e201CNV Deletion23290073
    esv3160CNV Duplication18987735
    nsv513736CNV Insertion21212237
    nsv509125CNV Insertion20534489
    nsv818409CNV Loss17921354
    dgv6573n71CNV Loss21882294


    Human Gene Mutation Database (HGMD): MICA

    Locus Specific Mutation Databases (LSDB): MICA
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing MICA
    DNA2.0 Custom Variant and Variant Library Synthesis for MICA

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600169OMIM information: 601799    
    UniProtKB/Swiss-Prot: MICA_HUMAN, Q29983
  • Note=Anti-MICA antibodies and ligand shedding are involved in the progression of monoclonal gammopathy of
    undetermined significance (MGUS)to multiple myeloma
  • Psoriasis 1 (PSORS1) [MIM:177900]: A common, chronic inflammatory disease of the skin with multifactorial
    etiology. It is characterized by red, scaly plaques usually found on the scalp, elbows and knees. These lesions
    are caused by abnormal keratinocyte proliferation and infiltration of inflammatory cells into the dermis and
    epidermis. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry
  • Psoriatic arthritis (PSORAS) [MIM:607507]: An inflammatory, seronegative arthritis associated with
    psoriasis. It is a heterogeneous disorder ranging from a mild, non-destructive disease to a severe, progressive,
    erosive arthropathy. Five types of psoriatic arthritis have been defined: asymmetrical oligoarthritis
    characterized by primary involvement of the small joints of the fingers or toes; asymmetrical arthritis which
    involves the joints of the extremities; symmetrical polyarthritis characterized by a rheumatoid like pattern that
    can involve hands, wrists, ankles, and feet; arthritis mutilans, which is a rare but deforming and destructive
    condition; arthritis of the sacroiliac joints and spine (psoriatic spondylitis). Note=Disease susceptibility is
    associated with variations affecting the gene represented in this entry

  • 20/96 diseases for MICA (see all 96):    About MalaCards
    hiv-1 viremia    histoplasmosis    psoriatic arthritis    stiff-person syndrome
    oral submucous fibrosis    takayasu's arteritis    type 1 diabetes    brucellosis
    chronic graft versus host disease    ankylosing spondylitis    cholelithiasis    mixed connective tissue disease
    type 1 diabetes mellitus    menieres disease    meniere's disease    ulcerative colitis
    spondyloarthropathy    sclerosing cholangitis    primary sclerosing cholangitis    connective tissue disease

    2 diseases from the University of Copenhagen DISEASES database for MICA:
    Celiac disease     Addison's disease

    MICA for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Genetic Association Database (GAD): MICA
    Human Genome Epidemiology (HuGE) Navigator: MICA (178 documents)

    Export disorders for MICA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MICA gene, integrated from 9 sources (see all 384):
    (articles sorted by number of sources associating them with MICA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The MICA-A9 triplet repeat polymorphism in the transmembrane region confers additional susceptibility to the development of psoriatic arthritis and is independent of the association of Cw*0602 in psoriasis. (PubMed id 10323458)1, 2, 4 Gonzalez S.... Lopez-Larrea C. (1999)
    2. A second lineage of mammalian major histocompatibility complex class I genes. (PubMed id 8022771)1, 2, 3 Bahram S.... Spies T. (1994)
    3. MICA polymorphism in a northern Chinese Han populatio n: The identification of a new MICA allele, MICA*059. (PubMed id 20097244)1, 4 Tian W....Li L.X. (2010)
    4. Association analysis of MICA gene polymorphism and MI CA-129 dimorphism with inflammatory bowel disease susceptibility in a Spanish p opulation. (PubMed id 20152875)1, 4 LA^pez-HernA!ndez R....Muro M. (2010)
    5. MICA polymorphisms and haplotypes with HLA-B and HLA- DRB1 in Koreans. (PubMed id 19895570)1, 4 Sohn Y.H....Kwon O.J. (2010)
    6. The major genetic determinants of HIV-1 control affec t HLA class I peptide presentation. (PubMed id 21051598)1, 4  ....Zhao M. (2010)
    7. Haplotype analysis discriminates genetic risk for DR3 -associated endocrine autoimmunity and helps define extreme risk for Addison's disease. (PubMed id 20631027)1, 4 Baker P.R....Eisenbarth G.S. (2010)
    8. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    9. [Association of MICA gene polymorphism and serum solu ble MICA level with colorectal cancer] (PubMed id 20533278)1, 4 Gong W.J....Ji M.C. (2010)
    10. Examination of genetic polymorphisms in newborns for signatures of sex-specific prenatal selection. (PubMed id 20587610)1, 4 Ucisik-Akkaya E....Tevfik Dorak M. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 100507436 HGNC: 7090 Ensembl:ENSG00000204520 euGenes: HUgn100507436 ECgene: MICA Kegg: 100507436
    H-InvDB: MICA

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MICA Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MICA Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MICA gene:
    Search GeneIP for patents involving MICA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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