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Aliases for MICA Gene

Aliases for MICA Gene

  • MHC Class I Polypeptide-Related Sequence A 2 3 5
  • PERB11.1 3 4
  • MIC-A 3 4
  • Truncated MHC Class I Polypeptide-Related Sequence A 3
  • MHC Class I Chain-Related Protein A 3
  • Stress Inducible Class I Homolog 3
  • MHC Class I Related Sequence A 3
  • MHC Class I Related Chain A 3
  • HLA Class I Antigen 3

External Ids for MICA Gene

Previous GeneCards Identifiers for MICA Gene

  • GC06P031425
  • GC06P031140
  • GC06P031471
  • GC06P031475
  • GC06P031479
  • GC06Pf31500
  • GC06Pc31510
  • GC06P031371
  • GC06P031370
  • GC06P031373

Summaries for MICA Gene

Entrez Gene Summary for MICA Gene

  • This gene encodes the highly polymorphic major histocompatability complex class I chain-related protein A. The protein product is expressed on the cell surface, although unlike canonical class I molecules it does not seem to associate with beta-2-microglobulin. It is a ligand for the NKG2-D type II integral membrane protein receptor. The protein functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells. Variations in this gene have been associated with susceptibility to psoriasis 1 and psoriatic arthritis, and the shedding of MICA-related antibodies and ligands is involved in the progression from monoclonal gammopathy of undetermined significance to multiple myeloma. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2014]

GeneCards Summary for MICA Gene

MICA (MHC Class I Polypeptide-Related Sequence A) is a Protein Coding gene. Diseases associated with MICA include Spondylitis and Psoriatic Arthritis. Among its related pathways are Immune response Role of DAP12 receptors in NK cells and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include antigen binding and natural killer cell lectin-like receptor binding. An important paralog of this gene is MICB.

UniProtKB/Swiss-Prot for MICA Gene

  • Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T-cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis.

Additional gene information for MICA Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MICA Gene

Genomics for MICA Gene

Regulatory Elements for MICA Gene

Enhancers for MICA Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06H031538 1.4 ENCODE dbSUPER 38.3 +141.4 141355 4 MLX ZFP64 FEZF1 DMAP1 YY1 ZNF143 SP3 MCM3 PPARGC1A MEF2D ATF6B LSM2 LY6G5B DDX39B MDC1 PPP1R10 NRM DHX16 MSH5 TCF19
GH06H031353 1.7 FANTOM5 Ensembl ENCODE dbSUPER 24.7 -43.6 -43593 6 HDGF PKNOX1 ATF1 NSD2 ZNF2 GLIS2 ZNF143 ZNF207 FOS RUNX3 HLA-C HLA-B DDX39B ENSG00000271581 MICA LY6G5B ATF6B RPL7P4 MICA-AS1 SKIV2L
GH06H031567 2 FANTOM5 Ensembl ENCODE dbSUPER 20.3 +178.6 178635 22 HDGF PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 YBX1 ZNF2 ZBTB7B TNF DDX39B LY6G5B ATF6B LSM2 TCF19 MDC1 DHX16 NFKBIL1 C6orf47
GH06H031545 1.2 ENCODE 33.5 +147.7 147749 3 MLX YBX1 FEZF1 DMAP1 YY1 ZNF143 SP3 NFYC ZC3H11A MEF2D DDX39B LSM2 LY6G5B ATF6B DHX16 MDC1 NRM TCF19 NFKBIL1 MICA
GH06H031733 1.9 FANTOM5 ENCODE dbSUPER 19.9 +337.7 337671 8 MLX ZFP64 YBX1 FEZF1 DMAP1 YY1 SLC30A9 SP3 NFYC ZC3H11A LY6G5B ATF6B DDX39B LSM2 CSNK2B GPANK1 VARS NFKBIL1 SKIV2L MSH5
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MICA on UCSC Golden Path with GeneCards custom track

Promoters for MICA Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000320239 716 2601 HDGF PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1

Genomic Location for MICA Gene

Chromosome:
6
Start:
31,399,784 bp from pter
End:
31,415,315 bp from pter
Size:
15,532 bases
Orientation:
Plus strand

Genomic View for MICA Gene

Genes around MICA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MICA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MICA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for MICA Gene

  • Protein details for MICA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q29983-MICA_HUMAN
    Recommended name:
    MHC class I polypeptide-related sequence A
    Protein Accession:
    Q29983
    Secondary Accessions:
    • A8KQR0
    • A9LRW5
    • A9QVE0
    • B1VJF1
    • O60917
    • O60918
    • O60919
    • O60920
    • O60933
    • O77956
    • O78150
    • O78151
    • O78152
    • O78153
    • O97987
    • O97988
    • O97989
    • O97990
    • O97991
    • O97992
    • O97993
    • O97994
    • O97995
    • O98234
    • O98235
    • O98236
    • O98237
    • O98238
    • P79506
    • P79507
    • P79508
    • P79509
    • P79510
    • P79511
    • P79512
    • P79513
    • P79514
    • P79515
    • P79516
    • P79517
    • P79518
    • P79519
    • P79520
    • P79521
    • Q5C9P8
    • Q5XM81
    • Q70I48
    • Q70I49
    • Q7JFH9
    • Q7JFI0
    • Q7JFI1
    • Q7JFI2
    • Q7YQ98
    • Q861I1
    • Q95464
    • Q95HA2
    • Q95HD6
    • Q95HN4
    • Q95HN5
    • Q95HN6
    • Q95IB2
    • Q95IY7
    • Q99692
    • Q9BCR3
    • Q9BCR4
    • Q9BCR5
    • Q9BCR6
    • Q9BCR7
    • Q9BCR8
    • Q9BCR9
    • Q9BCS0
    • Q9BCS1
    • Q9BCS2
    • Q9BCS3
    • Q9BCS4
    • Q9BD20
    • Q9GIZ1
    • Q9GIZ2
    • Q9GIZ3
    • Q9GIZ4
    • Q9GIZ5
    • Q9GIZ6
    • Q9GJ01
    • Q9GJ02
    • Q9GJ03
    • Q9GJ04
    • Q9GJ05
    • Q9GJ06
    • Q9GJ07
    • Q9GJ08
    • Q9GJ09
    • Q9MY21
    • Q9TQ86
    • Q9TQ87
    • Q9TQ88
    • Q9TQ89
    • Q9TQ92
    • Q9TQ93
    • Q9TQ94
    • Q9TQ95
    • Q9TQ96
    • Q9TQ97
    • Q9TQ98
    • Q9TQ99
    • Q9TQA0
    • Q9TQA1
    • Q9TQA2
    • Q9TQA3
    • Q9TQA4
    • Q9TQI9
    • Q9TQJ0
    • Q9TQJ1
    • Q9TQJ9
    • Q9TQK0
    • Q9TQK1
    • Q9TQK2
    • Q9TQK8
    • Q9TQK9
    • Q9TQL0
    • Q9TQL1
    • Q9TQL2
    • Q9TQL3
    • Q9TQL4
    • Q9UE04
    • Q9UE05
    • Q9UE06
    • Q9UE11

    Protein attributes for MICA Gene

    Size:
    383 amino acids
    Molecular mass:
    42915 Da
    Quaternary structure:
    • Unlike classical MHC class I molecules, does not form a heterodimer with beta-2-microglobulin. Binds as a monomer to a KLRK1/NKG2D homodimer. KLRK1 forms a complex with HCST/DAP10 in which KLRK1 binds MICA while HCST acts as an adapter molecule which enables signal transduction. Interacts with PDIA6 on the surface of tumor cells, leading to disulfide bond reduction which is required for release of MICA from tumor cells. Interacts with human cytomegalovirus/HHV-5 protein UL142.
    Miscellaneous:
    • Recognized by antibodies in the sera of some organ transplant recipients and may be a target molecule in allograft rejection.

    Three dimensional structures from OCA and Proteopedia for MICA Gene

    Alternative splice isoforms for MICA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MICA Gene

Post-translational modifications for MICA Gene

  • N-glycosylated. Glycosylation is not essential for interaction with KLRK1/NKG2D but enhances complex formation.
  • Proteolytically cleaved and released from the cell surface of tumor cells which impairs KLRK1/NKG2D expression and T-cell activation.
  • Glycosylation at Asn31, Asn79, Asn125, posLast=210210, posLast=220220, and posLast=261261
  • Modification sites at PhosphoSitePlus

Other Protein References for MICA Gene

Antibody Products

No data available for DME Specific Peptides for MICA Gene

Domains & Families for MICA Gene

Gene Families for MICA Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins

Graphical View of Domain Structure for InterPro Entry

Q29983

UniProtKB/Swiss-Prot:

MICA_HUMAN :
  • Belongs to the MHC class I family. MIC subfamily.
Family:
  • Belongs to the MHC class I family. MIC subfamily.
genes like me logo Genes that share domains with MICA: view

Function for MICA Gene

Molecular function for MICA Gene

GENATLAS Biochemistry:
MHC class I,chain-related gene A,43kDa,preferentially expressed in fibroblast and epithelial cell,with a repeat polymorphism in TM region possibly associated with Behcet disease,not involved in ankylosing spondylitis
UniProtKB/Swiss-Prot Function:
Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T-cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis.
UniProtKB/Swiss-Prot Induction:
By heat shock, by infection with human cytomegalovirus (HCMV), human adenovirus 5, M.tuberculosis and diarrheagenic E.coli, and by exposure to DNA damaging conditions such as high doses of ionizing radiation, chromatin-modifying treatments and inhibitors of DNA replication. The HCMV UL142 protein causes down-regulation of the full-length protein but not of the truncated MICA*008 allele.

Phenotypes From GWAS Catalog for MICA Gene

Gene Ontology (GO) - Molecular Function for MICA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11323699
GO:0030881 NOT beta-2-microglobulin binding IDA 8901601
GO:0046703 natural killer cell lectin-like receptor binding IPI 10426993
genes like me logo Genes that share ontologies with MICA: view
genes like me logo Genes that share phenotypes with MICA: view

Animal Model Products

CRISPR Products

miRNA for MICA Gene

miRTarBase miRNAs that target MICA

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for MICA
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MICA Gene

Localization for MICA Gene

Subcellular locations from UniProtKB/Swiss-Prot for MICA Gene

Cell membrane; Single-pass type I membrane protein. Cytoplasm. Note=Expressed on the cell surface in gastric epithelium, endothelial cells and fibroblasts and in the cytoplasm in keratinocytes and monocytes. Infection with human adenovirus 5 suppresses cell surface expression due to the adenoviral E3-19K protein which causes retention in the endoplasmic reticulum. {ECO:0000269 PubMed:10363723, ECO:0000269 PubMed:18287244, ECO:0000269 PubMed:8901601}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MICA gene
Compartment Confidence
plasma membrane 3
extracellular 2
nucleus 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for MICA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 18676862
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IDA 18676862
GO:0009986 cell surface IDA 8901601
genes like me logo Genes that share ontologies with MICA: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MICA Gene

Pathways & Interactions for MICA Gene

genes like me logo Genes that share pathways with MICA: view

Interacting Proteins for MICA Gene

Selected Interacting proteins: Q29983-MICA_HUMAN for MICA Gene via IID UniProtKB MINT

Symbol External ID(s) Details
HLA-B
HLA-A
HLA-C
LGALS3
KLRK1

Gene Ontology (GO) - Biological Process for MICA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001913 T cell mediated cytotoxicity IDA 10426993
GO:0002418 immune response to tumor cell IDA 10359807
GO:0006974 cellular response to DNA damage stimulus IDA 15995699
GO:0009408 response to heat IDA 8901601
GO:0016032 viral process IEA --
genes like me logo Genes that share ontologies with MICA: view

No data available for SIGNOR curated interactions for MICA Gene

Drugs & Compounds for MICA Gene

No Compound Related Data Available

Transcripts for MICA Gene

mRNA/cDNA for MICA Gene

(5) REFSEQ mRNAs :
(12) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MICA Gene

MHC class I polypeptide-related sequence A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for MICA
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MICA Gene

No ASD Table

Relevant External Links for MICA Gene

GeneLoc Exon Structure for
MICA
ECgene alternative splicing isoforms for
MICA

Expression for MICA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MICA Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MICA Gene



NURSA nuclear receptor signaling pathways regulating expression of MICA Gene:

MICA

SOURCE GeneReport for Unigene cluster for MICA Gene:

Hs.130838

mRNA Expression by UniProt/SwissProt for MICA Gene:

Q29983-MICA_HUMAN
Tissue specificity: Widely expressed with the exception of the central nervous system where it is absent. Expressed predominantly in gastric epithelium and also in monocytes, keratinocytes, endothelial cells, fibroblasts and in the outer layer of Hassals corpuscles within the medulla of normal thymus. In skin, expressed mainly in the keratin layers, basal cells, ducts and follicles. Also expressed in many, but not all, epithelial tumors of lung, breast, kidney, ovary, prostate and colon. In thyomas, overexpressed in cortical and medullar epithelial cells. Tumors expressing MICA display increased levels of gamma delta T-cells.

Evidence on tissue expression from TISSUES for MICA Gene

  • Blood(2.6)
genes like me logo Genes that share expression patterns with MICA: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for MICA Gene

Orthologs for MICA Gene

This gene was present in the common ancestor of chordates.

Orthologs for MICA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MICB 34
  • 73 (a)
OneToMany
cow
(Bos Taurus)
Mammalia -- 34
  • 37 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia MILL-LIKE 34
  • 26 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Mill1 34
  • 26 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 18 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 34
  • 28 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 22 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii si:ch211-147g22.4 34
  • 23 (a)
ManyToMany
BX572619.3 34
  • 20 (a)
ManyToMany
mhc1uba 34
  • 20 (a)
ManyToMany
mhc1zca 34
  • 20 (a)
ManyToMany
mhc1zea 34
  • 20 (a)
ManyToMany
si:ch211-147g22.1 34
  • 20 (a)
ManyToMany
CR339041.1 34
  • 19 (a)
ManyToMany
mhc1uca 34
  • 19 (a)
ManyToMany
si:dkey-52p2.7 34
  • 19 (a)
ManyToMany
BX572619.1 34
  • 18 (a)
ManyToMany
BX572619.2 34
  • 18 (a)
ManyToMany
BX682558.1 34
  • 18 (a)
ManyToMany
CU571323.1 34
  • 18 (a)
ManyToMany
mhc1zfa 34
  • 18 (a)
ManyToMany
si:ch211-147g22.3 34
  • 18 (a)
ManyToMany
si:dkey-52p2.6 34
  • 18 (a)
ManyToMany
CABZ01031753.1 34
  • 17 (a)
ManyToMany
DARE-ZE*0601 34
  • 17 (a)
ManyToMany
mhc1zaa 34 34
  • 17 (a)
ManyToMany
mhc1zba 34
  • 17 (a)
ManyToMany
si:ch211-147g22.2 34
  • 17 (a)
ManyToMany
arpc1a 34
  • 16 (a)
ManyToMany
CR339041.2 34
  • 16 (a)
ManyToMany
si:dkey-52p2.4 34
  • 16 (a)
ManyToMany
CABZ01031754.1 34
  • 15 (a)
ManyToMany
zgc:113060 34
  • 15 (a)
ManyToMany
Species where no ortholog for MICA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MICA Gene

ENSEMBL:
Gene Tree for MICA (if available)
TreeFam:
Gene Tree for MICA (if available)

Paralogs for MICA Gene

Paralogs for MICA Gene

genes like me logo Genes that share paralogs with MICA: view

Variants for MICA Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for MICA Gene

MICA_HUMAN-Q29983
The following alleles of MICA are known: MICA*001, MICA*002, MICA*004, MICA*005, MICA*006, MICA*007, MICA*008, MICA*009, MICA*010, MICA*011, MICA*012, MICA*013, MICA*014, MICA*015, MICA*016, MICA*017, MICA*018, MICA*019, MICA*020, MICA*022, MICA*023, MICA*024, MICA*025, MICA*026, MICA*027, MICA*028, MICA*029, MICA*030, MICA*031, MICA*032, MICA*033, MICA*034, MICA*035, MICA*036, MICA*037, MICA*038, MICA*039, MICA*040, MICA*041, MICA*042, MICA*043, MICA*044, MICA*045, MICA*046, MICA*047, MICA*048, MICA*049, MICA*050, MICA*051, MICA*052, MICA*053, MICA*054, MICA*055 and MICA*056. The sequence shown is that of MICA*001.

Sequence variations from dbSNP and Humsavar for MICA Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs41540613 Benign 31,412,063(+) ATGGG(C/G)TATCT reference, missense
rs1000359507 -- 31,399,954(+) GGCGG(A/G)CGCTG nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000911754 -- 31,398,009(+) AGCTT(C/G)GAGTA intron-variant, upstream-variant-2KB
rs1001009814 -- 31,410,580(+) CTGTC(C/T)TGGGA reference, synonymous-codon, utr-variant-5-prime
rs1001126437 -- 31,403,706(+) TGGTG(A/G)GTGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MICA Gene

Variant ID Type Subtype PubMed ID
dgv10393n54 CNV loss 21841781
dgv10403n54 CNV loss 21841781
dgv10404n54 CNV loss 21841781
dgv10453n54 CNV loss 21841781
dgv10454n54 CNV gain 21841781
dgv10455n54 CNV loss 21841781
dgv10456n54 CNV loss 21841781
dgv10457n54 CNV loss 21841781
dgv10458n54 CNV loss 21841781
dgv10459n54 CNV loss 21841781
dgv1098e199 CNV deletion 23128226
dgv1751e212 CNV gain 25503493
dgv1752e212 CNV loss 25503493
dgv213e55 CNV gain 17911159
dgv214e55 CNV gain 17911159
dgv215e55 CNV loss 17911159
dgv5942n100 CNV loss 25217958
dgv5943n100 CNV gain+loss 25217958
dgv5944n100 CNV loss 25217958
dgv747n27 CNV loss 19166990
dgv748n27 CNV loss 19166990
dgv995e201 CNV deletion 23290073
esv2432528 CNV deletion 19546169
esv26480 CNV loss 19812545
esv2731822 CNV deletion 23290073
esv2759414 CNV gain+loss 17122850
esv2762584 CNV loss 21179565
esv2763959 CNV gain+loss 21179565
esv29968 CNV gain 17803354
esv3160 OTHER sequence alteration 18987735
esv33563 CNV gain+loss 17666407
esv34063 CNV loss 18971310
esv3411275 CNV duplication 20981092
esv3608561 CNV loss 21293372
esv3890819 CNV loss 25118596
esv3890820 CNV loss 25118596
nsv1022499 CNV gain 25217958
nsv1030802 CNV gain 25217958
nsv1074389 CNV deletion 25765185
nsv10820 CNV gain+loss 18304495
nsv1112899 CNV deletion 24896259
nsv1144139 CNV deletion 24896259
nsv1161369 CNV deletion 26073780
nsv428140 CNV gain+loss 18775914
nsv435829 CNV deletion 17901297
nsv437496 CNV loss 16327808
nsv441990 CNV loss 18776908
nsv462854 CNV gain 19166990
nsv509125 CNV insertion 20534489
nsv511868 CNV loss 21212237
nsv513736 CNV insertion 21212237
nsv517441 CNV gain+loss 19592680
nsv601608 CNV loss 21841781
nsv601880 CNV gain+loss 21841781
nsv601922 CNV loss 21841781
nsv601923 CNV loss 21841781
nsv818409 CNV loss 17921354
nsv823497 CNV loss 20364138
nsv965706 CNV duplication 23825009
nsv970363 CNV duplication 23825009

Variation tolerance for MICA Gene

Residual Variation Intolerance Score: 98.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 18.71; 98.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MICA Gene

Human Gene Mutation Database (HGMD)
MICA
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MICA

Disorders for MICA Gene

MalaCards: The human disease database

(19) MalaCards diseases for MICA Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
spondylitis
psoriatic arthritis
  • arthritis psoriatica
multiple myeloma
  • plasma cell neoplasm
ocular toxoplasmosis
  • toxoplasmosis ocular
psoriasis
- elite association - COSMIC cancer census association via MalaCards
Search MICA in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

MICA_HUMAN
  • Note=Anti-MICA antibodies and ligand shedding are involved in the progression of monoclonal gammopathy of undetermined significance (MGUS)to multiple myeloma.
  • Psoriasis 1 (PSORS1) [MIM:177900]: A common, chronic inflammatory disease of the skin with multifactorial etiology. It is characterized by red, scaly plaques usually found on the scalp, elbows and knees. These lesions are caused by abnormal keratinocyte proliferation and infiltration of inflammatory cells into the dermis and epidermis. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
  • Psoriatic arthritis (PSORAS) [MIM:607507]: An inflammatory, seronegative arthritis associated with psoriasis. It is a heterogeneous disorder ranging from a mild, non-destructive disease to a severe, progressive, erosive arthropathy. Five types of psoriatic arthritis have been defined: asymmetrical oligoarthritis characterized by primary involvement of the small joints of the fingers or toes; asymmetrical arthritis which involves the joints of the extremities; symmetrical polyarthritis characterized by a rheumatoid like pattern that can involve hands, wrists, ankles, and feet; arthritis mutilans, which is a rare but deforming and destructive condition; arthritis of the sacroiliac joints and spine (psoriatic spondylitis). {ECO:0000269 PubMed:10323458}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Relevant External Links for MICA

Genetic Association Database (GAD)
MICA
Human Genome Epidemiology (HuGE) Navigator
MICA
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MICA
genes like me logo Genes that share disorders with MICA: view

No data available for Genatlas for MICA Gene

Publications for MICA Gene

  1. The MICA-A9 triplet repeat polymorphism in the transmembrane region confers additional susceptibility to the development of psoriatic arthritis and is independent of the association of Cw*0602 in psoriasis. (PMID: 10323458) Gonzalez S … López-Larrea C (Arthritis and rheumatism 1999) 3 4 45 60
  2. A second lineage of mammalian major histocompatibility complex class I genes. (PMID: 8022771) Bahram S … Spies T (Proceedings of the National Academy of Sciences of the United States of America 1994) 2 3 4 60
  3. Association analysis of MICA gene polymorphism and MICA-129 dimorphism with inflammatory bowel disease susceptibility in a Spanish population. (PMID: 20152875) López-Hernández R … Muro M (Human immunology 2010) 3 45 60
  4. Examination of genetic polymorphisms in newborns for signatures of sex-specific prenatal selection. (PMID: 20587610) Ucisik-Akkaya E … Dorak MT (Molecular human reproduction 2010) 3 45 60
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 45 60

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