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Aliases for MICA Gene

Aliases for MICA Gene

  • MHC Class I Polypeptide-Related Sequence A 2 3
  • PERB11.1 3 4
  • MIC-A 3 4
  • MHC Class I Chain-Related Protein A 3
  • Stress Inducible Class I Homolog 3
  • HLA Class I Antigen 3

External Ids for MICA Gene

Summaries for MICA Gene

Entrez Gene Summary for MICA Gene

  • This gene encodes the highly polymorphic major histocompatability complex class I chain-related protein A. The protein product is expressed on the cell surface, although unlike canonical class I molecules it does not seem to associate with beta-2-microglobulin. It is a ligand for the NKG2-D type II integral membrane protein receptor. The protein functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells. Variations in this gene have been associated with susceptibility to psoriasis 1 and psoriatic arthritis, and the shedding of MICA-related antibodies and ligands is involved in the progression from monoclonal gammopathy of undetermined significance to multiple myeloma. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2014]

GeneCards Summary for MICA Gene

MICA (MHC Class I Polypeptide-Related Sequence A) is a Protein Coding gene. Diseases associated with MICA include histoplasmosis and psoriatic arthritis. Among its related pathways are Immune response Role of DAP12 receptors in NK cells and Allograft rejection. GO annotations related to this gene include antigen binding and beta-2-microglobulin binding. An important paralog of this gene is MICB.

UniProtKB/Swiss-Prot for MICA Gene

  • Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T-cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MICA Gene

Genomics for MICA Gene

Genomic Location for MICA Gene

Start:
31,399,784 bp from pter
End:
31,415,315 bp from pter
Size:
15,532 bases
Orientation:
Plus strand

Genomic View for MICA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MICA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Regulatory Elements for MICA Gene

Proteins for MICA Gene

  • Protein details for MICA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q29983-MICA_HUMAN
    Recommended name:
    MHC class I polypeptide-related sequence A
    Protein Accession:
    Q29983
    Secondary Accessions:
    • A8KQR0
    • A9LRW5
    • A9QVE0
    • B1VJF1
    • O60917
    • O60918
    • O60919
    • O60920
    • O60933
    • O77956
    • O78150
    • O78151
    • O78152
    • O78153
    • O97987
    • O97988
    • O97989
    • O97990
    • O97991
    • O97992
    • O97993
    • O97994
    • O97995
    • O98234
    • O98235
    • O98236
    • O98237
    • O98238
    • P79506
    • P79507
    • P79508
    • P79509
    • P79510
    • P79511
    • P79512
    • P79513
    • P79514
    • P79515
    • P79516
    • P79517
    • P79518
    • P79519
    • P79520
    • P79521
    • Q5C9P8
    • Q5XM81
    • Q70I48
    • Q70I49
    • Q7JFH9
    • Q7JFI0
    • Q7JFI1
    • Q7JFI2
    • Q7YQ98
    • Q861I1
    • Q95464
    • Q95HA2
    • Q95HD6
    • Q95HN4
    • Q95HN5
    • Q95HN6
    • Q95IB2
    • Q95IY7
    • Q99692
    • Q9BCR3
    • Q9BCR4
    • Q9BCR5
    • Q9BCR6
    • Q9BCR7
    • Q9BCR8
    • Q9BCR9
    • Q9BCS0
    • Q9BCS1
    • Q9BCS2
    • Q9BCS3
    • Q9BCS4
    • Q9BD20
    • Q9GIZ1
    • Q9GIZ2
    • Q9GIZ3
    • Q9GIZ4
    • Q9GIZ5
    • Q9GIZ6
    • Q9GJ01
    • Q9GJ02
    • Q9GJ03
    • Q9GJ04
    • Q9GJ05
    • Q9GJ06
    • Q9GJ07
    • Q9GJ08
    • Q9GJ09
    • Q9MY21
    • Q9TQ86
    • Q9TQ87
    • Q9TQ88
    • Q9TQ89
    • Q9TQ92
    • Q9TQ93
    • Q9TQ94
    • Q9TQ95
    • Q9TQ96
    • Q9TQ97
    • Q9TQ98
    • Q9TQ99
    • Q9TQA0
    • Q9TQA1
    • Q9TQA2
    • Q9TQA3
    • Q9TQA4
    • Q9TQI9
    • Q9TQJ0
    • Q9TQJ1
    • Q9TQJ9
    • Q9TQK0
    • Q9TQK1
    • Q9TQK2
    • Q9TQK8
    • Q9TQK9
    • Q9TQL0
    • Q9TQL1
    • Q9TQL2
    • Q9TQL3
    • Q9TQL4
    • Q9UE04
    • Q9UE05
    • Q9UE06
    • Q9UE11

    Protein attributes for MICA Gene

    Size:
    383 amino acids
    Molecular mass:
    42915 Da
    Quaternary structure:
    • Unlike classical MHC class I molecules, does not form a heterodimer with beta-2-microglobulin. Binds as a monomer to a KLRK1/NKG2D homodimer. KLRK1 forms a complex with HCST/DAP10 in which KLRK1 binds MICA while HCST acts as an adapter molecule which enables signal transduction. Interacts with PDIA6 on the surface of tumor cells, leading to disulfide bond reduction which is required for release of MICA from tumor cells. Interacts with human cytomegalovirus/HHV-5 protein UL142.
    Miscellaneous:
    • Recognized by antibodies in the sera of some organ transplant recipients and may be a target molecule in allograft rejection.

    Three dimensional structures from OCA and Proteopedia for MICA Gene

    Alternative splice isoforms for MICA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MICA Gene

Proteomics data for MICA Gene at MOPED

Post-translational modifications for MICA Gene

  • N-glycosylated. Glycosylation is not essential for interaction with KLRK1/NKG2D but enhances complex formation.
  • Proteolytically cleaved and released from the cell surface of tumor cells which impairs KLRK1/NKG2D expression and T-cell activation.
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn31, Asn79, Asn125, Asn210, Asn220, and Asn261

Other Protein References for MICA Gene

No data available for DME Specific Peptides for MICA Gene

Domains for MICA Gene

Gene Families for MICA Gene

HGNC:
  • C1SET :Immunoglobulin superfamily / C1-set domain containing

UniProtKB/Swiss-Prot:

MICA_HUMAN
Domain:
  • Contains 1 Ig-like C1-type (immunoglobulin-like) domain.:
    • Q29983
Family:
  • Belongs to the MHC class I family. MIC subfamily.:
    • Q29983
genes like me logo Genes that share domains with MICA: view

Function for MICA Gene

Molecular function for MICA Gene

GENATLAS Biochemistry: MHC class I,chain-related gene A,43kDa,preferentially expressed in fibroblast and epithelial cell,with a repeat polymorphism in TM region possibly associated with Behcet disease,not involved in ankylosing spondylitis
UniProtKB/Swiss-Prot Function: Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T-cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis.
UniProtKB/Swiss-Prot Induction: By heat shock, by infection with human cytomegalovirus (HCMV), human adenovirus 5, M.tuberculosis and diarrheagenic E.coli, and by exposure to DNA damaging conditions such as high doses of ionizing radiation, chromatin-modifying treatments and inhibitors of DNA replication. The HCMV UL142 protein causes down-regulation of the full-length protein but not of the truncated MICA*008 allele.

Gene Ontology (GO) - Molecular Function for MICA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding IBA --
GO:0005515 protein binding IPI 11323699
GO:0030881 NOT beta-2-microglobulin binding IDA 8901601
GO:0046703 natural killer cell lectin-like receptor binding IPI 10426993
genes like me logo Genes that share ontologies with MICA: view

miRNA for MICA Gene

miRTarBase miRNAs that target MICA

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for MICA Gene

Localization for MICA Gene

Subcellular locations from UniProtKB/Swiss-Prot for MICA Gene

Cell membrane; Single-pass type I membrane protein. Cytoplasm. Note=Expressed on the cell surface in gastric epithelium, endothelial cells and fibroblasts and in the cytoplasm in keratinocytes and monocytes. Infection with human adenovirus 5 suppresses cell surface expression due to the adenoviral E3-19K protein which causes retention in the endoplasmic reticulum. {ECO:0000269 PubMed:10363723, ECO:0000269 PubMed:18287244, ECO:0000269 PubMed:8901601}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MICA Gene COMPARTMENTS Subcellular localization image for MICA gene
Compartment Confidence
plasma membrane 5
extracellular 4
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for MICA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 18676862
GO:0005737 cytoplasm IEA --
GO:0005887 integral component of plasma membrane IDA 18676862
GO:0009986 cell surface IDA 18676862
GO:0016020 membrane --
genes like me logo Genes that share ontologies with MICA: view

Pathways for MICA Gene

genes like me logo Genes that share pathways with MICA: view

Pathways by source for MICA Gene

1 BioSystems pathway for MICA Gene
1 KEGG pathway for MICA Gene

Interacting Proteins for MICA Gene

Gene Ontology (GO) - Biological Process for MICA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001913 T cell mediated cytotoxicity IDA 10426993
GO:0002418 immune response to tumor cell IDA 10359807
GO:0006955 immune response --
GO:0006974 cellular response to DNA damage stimulus IDA 15995699
GO:0009408 response to heat IDA 8901601
genes like me logo Genes that share ontologies with MICA: view

Transcripts for MICA Gene

mRNA/cDNA for MICA Gene

(5) REFSEQ mRNAs :
(12) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MICA Gene

MHC class I polypeptide-related sequence A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MICA Gene

No ASD Table

Relevant External Links for MICA Gene

GeneLoc Exon Structure for
MICA
ECgene alternative splicing isoforms for
MICA

Expression for MICA Gene

mRNA expression in normal human tissues for MICA Gene

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for MICA Gene

SOURCE GeneReport for Unigene cluster for MICA Gene Hs.130838

mRNA Expression by UniProt/SwissProt for MICA Gene

Q29983-MICA_HUMAN
Tissue specificity: Widely expressed with the exception of the central nervous system where it is absent. Expressed predominantly in gastric epithelium and also in monocytes, keratinocytes, endothelial cells, fibroblasts and in the outer layer of Hassals corpuscles within the medulla of normal thymus. In skin, expressed mainly in the keratin layers, basal cells, ducts and follicles. Also expressed in many, but not all, epithelial tumors of lung, breast, kidney, ovary, prostate and colon. In thyomas, overexpressed in cortical and medullar epithelial cells. Tumors expressing MICA display increased levels of gamma delta T-cells.
genes like me logo Genes that share expressions with MICA: view

Orthologs for MICA Gene

This gene was present in the common ancestor of chordates.

Orthologs for MICA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MICB 37
  • 73 (a)
OneToMany
cow
(Bos Taurus)
Mammalia -- 37
  • 37 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Mill1 37
  • 26 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia MILL-LIKE 37
  • 26 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 18 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 37
  • 28 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 22 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii arpc1a 37
  • 16 (a)
ManyToMany
BX572619.1 37
  • 18 (a)
ManyToMany
BX572619.2 37
  • 18 (a)
ManyToMany
BX572619.3 37
  • 20 (a)
ManyToMany
BX682558.1 37
  • 18 (a)
ManyToMany
CABZ01031753.1 37
  • 17 (a)
ManyToMany
CABZ01031754.1 37
  • 15 (a)
ManyToMany
CR339041.1 37
  • 19 (a)
ManyToMany
CR339041.2 37
  • 16 (a)
ManyToMany
CU571323.1 37
  • 18 (a)
ManyToMany
DARE-ZE*0601 37
  • 17 (a)
ManyToMany
mhc1uba 37
  • 20 (a)
ManyToMany
mhc1uca 37
  • 19 (a)
ManyToMany
mhc1zaa 37
  • 17 (a)
ManyToMany
mhc1zaa 37
  • 17 (a)
ManyToMany
mhc1zba 37
  • 17 (a)
ManyToMany
mhc1zca 37
  • 20 (a)
ManyToMany
mhc1zea 37
  • 20 (a)
ManyToMany
mhc1zfa 37
  • 18 (a)
ManyToMany
si:ch211-147g22.1 37
  • 20 (a)
ManyToMany
si:ch211-147g22.2 37
  • 17 (a)
ManyToMany
si:ch211-147g22.3 37
  • 18 (a)
ManyToMany
si:ch211-147g22.4 37
  • 23 (a)
ManyToMany
si:dkey-52p2.4 37
  • 16 (a)
ManyToMany
si:dkey-52p2.6 37
  • 18 (a)
ManyToMany
si:dkey-52p2.7 37
  • 19 (a)
ManyToMany
zgc:113060 37
  • 15 (a)
ManyToMany
Species with no ortholog for MICA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MICA Gene

ENSEMBL:
Gene Tree for MICA (if available)
TreeFam:
Gene Tree for MICA (if available)

Paralogs for MICA Gene

Paralogs for MICA Gene

genes like me logo Genes that share paralogs with MICA: view

Variants for MICA Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for MICA Gene

Q29983-MICA_HUMAN
The following alleles of MICA are known: MICA*001, MICA*002, MICA*004, MICA*005, MICA*006, MICA*007, MICA*008, MICA*009, MICA*010, MICA*011, MICA*012, MICA*013, MICA*014, MICA*015, MICA*016, MICA*017, MICA*018, MICA*019, MICA*020, MICA*022, MICA*023, MICA*024, MICA*025, MICA*026, MICA*027, MICA*028, MICA*029, MICA*030, MICA*031, MICA*032, MICA*033, MICA*034, MICA*035, MICA*036, MICA*037, MICA*038, MICA*039, MICA*040, MICA*041, MICA*042, MICA*043, MICA*044, MICA*045, MICA*046, MICA*047, MICA*048, MICA*049, MICA*050, MICA*051, MICA*052, MICA*053, MICA*054, MICA*055 and MICA*056. The sequence shown is that of MICA*001.

Sequence variations from dbSNP and Humsavar for MICA Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs1880 -- 31,415,217(-) GGTCA(G/T)GAAAC utr-variant-3-prime
rs1882 -- 31,415,134(+) AGGGC(A/G)CCTAG utr-variant-3-prime
rs1051785 - 31,410,611(+) TTCTT(A/G)CTGAG missense, reference, utr-variant-5-prime
rs1051786 - 31,410,648(+) GCGCT(A/G)TGACA missense, reference, utr-variant-5-prime
rs1051790 - 31,411,179(+) AAAAC(C/G)TGGAG reference, missense, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MICA Gene

Variant ID Type Subtype PubMed ID
nsv428140 CNV Gain+Loss 18775914
esv690 CNV CNV 17122850
dgv1042e201 CNV Deletion 23290073
dgv1921e1 CNV Complex 17122850
esv33563 CNV Gain+Loss 17666407
nsv884319 CNV Gain 21882294
nsv517441 CNV Gain+Loss 19592680
nsv509125 CNV Insertion 20534489
dgv213e55 CNV Gain 17911159
dgv214e55 CNV Gain 17911159
dgv1926e1 CNV Complex 17122850
essv13266 CNV CNV 17122850
esv34063 CNV Loss 18971310
esv26480 CNV Loss 19812545
dgv6571n71 CNV Loss 21882294
dgv747n27 CNV Loss 19166990
dgv1098e199 CNV Deletion 23128226
esv2731822 CNV Deletion 23290073
esv3160 CNV Duplication 18987735
nsv511868 CNV Loss 21212237
nsv513736 CNV Insertion 21212237
esv2432528 CNV Deletion 19546169
dgv6573n71 CNV Loss 21882294
nsv435829 CNV Deletion 17901297
nsv10820 CNV Gain+Loss 18304495
nsv884353 CNV Gain 21882294
nsv884354 CNV Loss 21882294
dgv6574n71 CNV Gain 21882294
dgv6575n71 CNV Gain+Loss 21882294
nsv823497 CNV Loss 20364138
dgv215e55 CNV Loss 17911159
esv29968 CNV Gain 17803354
nsv441990 CNV CNV 18776908
dgv748n27 CNV Loss 19166990
nsv462854 CNV Gain 19166990
nsv818409 CNV Loss 17921354
nsv884382 CNV Loss 21882294
nsv437496 CNV Loss 16327808

Relevant External Links for MICA Gene

HapMap Linkage Disequilibrium report
MICA
Human Gene Mutation Database (HGMD)
MICA
Locus Specific Mutation Databases (LSDB)
MICA

Disorders for MICA Gene

UniProtKB/Swiss-Prot

MICA_HUMAN
  • Note=Anti-MICA antibodies and ligand shedding are involved in the progression of monoclonal gammopathy of undetermined significance (MGUS)to multiple myeloma.
  • Psoriasis 1 (PSORS1) [MIM:177900]: A common, chronic inflammatory disease of the skin with multifactorial etiology. It is characterized by red, scaly plaques usually found on the scalp, elbows and knees. These lesions are caused by abnormal keratinocyte proliferation and infiltration of inflammatory cells into the dermis and epidermis. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
  • Psoriatic arthritis (PSORAS) [MIM:607507]: An inflammatory, seronegative arthritis associated with psoriasis. It is a heterogeneous disorder ranging from a mild, non-destructive disease to a severe, progressive, erosive arthropathy. Five types of psoriatic arthritis have been defined: asymmetrical oligoarthritis characterized by primary involvement of the small joints of the fingers or toes; asymmetrical arthritis which involves the joints of the extremities; symmetrical polyarthritis characterized by a rheumatoid like pattern that can involve hands, wrists, ankles, and feet; arthritis mutilans, which is a rare but deforming and destructive condition; arthritis of the sacroiliac joints and spine (psoriatic spondylitis). {ECO:0000269 PubMed:10323458}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

(2) University of Copenhagen DISEASES for MICA Gene

Relevant External Links for MICA

Genetic Association Database (GAD)
MICA
Human Genome Epidemiology (HuGE) Navigator
MICA
genes like me logo Genes that share disorders with MICA: view

Publications for MICA Gene

  1. A second lineage of mammalian major histocompatibility complex class I genes. (PMID: 8022771) Bahram S. … Spies T. (Proc. Natl. Acad. Sci. U.S.A. 1994) 2 3 4
  2. The MICA-A9 triplet repeat polymorphism in the transmembrane region confers additional susceptibility to the development of psoriatic arthritis and is independent of the association of Cw*0602 in psoriasis. (PMID: 10323458) Gonzalez S. … Lopez-Larrea C. (Arthritis Rheum. 1999) 3 4 49
  3. Definition of new alleles of MIC-A using sequencing-based typing. (PMID: 10331160) Yao Z. … Albert E.D. (Eur. J. Immunogenet. 1999) 3 4
  4. Broad tumor-associated expression and recognition by tumor-derived gamma delta T cells of MICA and MICB. (PMID: 10359807) Groh V. … Spies T. (Proc. Natl. Acad. Sci. U.S.A. 1999) 3 4
  5. Differential surface expression of MICA by endothelial cells, fibroblasts, keratinocytes, and monocytes. (PMID: 10363723) Zwirner N.W. … Stastny P. (Hum. Immunol. 1999) 3 4

Products for MICA Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate MICA
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for MICA
    • Block miRNA regulation of MICA using miScript Target Protectors

    Sources for MICA Gene

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