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Aliases for MICA Gene

Aliases for MICA Gene

  • MHC Class I Polypeptide-Related Sequence A 2 3 5
  • PERB11.1 3 4
  • MIC-A 3 4
  • Truncated MHC Class I Polypeptide-Related Sequence A 3
  • MHC Class I Chain-Related Protein A 3
  • Stress Inducible Class I Homolog 3
  • MHC Class I Related Sequence A 3
  • HLA Class I Antigen 3

External Ids for MICA Gene

Previous GeneCards Identifiers for MICA Gene

  • GC06P031425
  • GC06P031140
  • GC06P031471
  • GC06P031475
  • GC06P031479
  • GC06Pf31500
  • GC06Pc31510
  • GC06P031371
  • GC06P031370
  • GC06P031373

Summaries for MICA Gene

Entrez Gene Summary for MICA Gene

  • This gene encodes the highly polymorphic major histocompatability complex class I chain-related protein A. The protein product is expressed on the cell surface, although unlike canonical class I molecules it does not seem to associate with beta-2-microglobulin. It is a ligand for the NKG2-D type II integral membrane protein receptor. The protein functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells. Variations in this gene have been associated with susceptibility to psoriasis 1 and psoriatic arthritis, and the shedding of MICA-related antibodies and ligands is involved in the progression from monoclonal gammopathy of undetermined significance to multiple myeloma. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2014]

GeneCards Summary for MICA Gene

MICA (MHC Class I Polypeptide-Related Sequence A) is a Protein Coding gene. Diseases associated with MICA include Spondylitis and Psoriatic Arthritis. Among its related pathways are Natural Killer Cell Receptors: Human Target Cell ?�� NK Cell Ligand-Receptor Interactions and Immune System. GO annotations related to this gene include antigen binding and natural killer cell lectin-like receptor binding. An important paralog of this gene is MICB.

UniProtKB/Swiss-Prot for MICA Gene

  • Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T-cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MICA Gene

Genomics for MICA Gene

Regulatory Elements for MICA Gene

Enhancers for MICA Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MICA on UCSC Golden Path with GeneCards custom track

Promoters for MICA Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MICA on UCSC Golden Path with GeneCards custom track

Genomic Location for MICA Gene

31,399,784 bp from pter
31,415,315 bp from pter
15,532 bases
Plus strand

Genomic View for MICA Gene

Genes around MICA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MICA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MICA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for MICA Gene

  • Protein details for MICA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    MHC class I polypeptide-related sequence A
    Protein Accession:
    Secondary Accessions:
    • A8KQR0
    • A9LRW5
    • A9QVE0
    • B1VJF1
    • O60917
    • O60918
    • O60919
    • O60920
    • O60933
    • O77956
    • O78150
    • O78151
    • O78152
    • O78153
    • O97987
    • O97988
    • O97989
    • O97990
    • O97991
    • O97992
    • O97993
    • O97994
    • O97995
    • O98234
    • O98235
    • O98236
    • O98237
    • O98238
    • P79506
    • P79507
    • P79508
    • P79509
    • P79510
    • P79511
    • P79512
    • P79513
    • P79514
    • P79515
    • P79516
    • P79517
    • P79518
    • P79519
    • P79520
    • P79521
    • Q5C9P8
    • Q5XM81
    • Q70I48
    • Q70I49
    • Q7JFH9
    • Q7JFI0
    • Q7JFI1
    • Q7JFI2
    • Q7YQ98
    • Q861I1
    • Q95464
    • Q95HA2
    • Q95HD6
    • Q95HN4
    • Q95HN5
    • Q95HN6
    • Q95IB2
    • Q95IY7
    • Q99692
    • Q9BCR3
    • Q9BCR4
    • Q9BCR5
    • Q9BCR6
    • Q9BCR7
    • Q9BCR8
    • Q9BCR9
    • Q9BCS0
    • Q9BCS1
    • Q9BCS2
    • Q9BCS3
    • Q9BCS4
    • Q9BD20
    • Q9GIZ1
    • Q9GIZ2
    • Q9GIZ3
    • Q9GIZ4
    • Q9GIZ5
    • Q9GIZ6
    • Q9GJ01
    • Q9GJ02
    • Q9GJ03
    • Q9GJ04
    • Q9GJ05
    • Q9GJ06
    • Q9GJ07
    • Q9GJ08
    • Q9GJ09
    • Q9MY21
    • Q9TQ86
    • Q9TQ87
    • Q9TQ88
    • Q9TQ89
    • Q9TQ92
    • Q9TQ93
    • Q9TQ94
    • Q9TQ95
    • Q9TQ96
    • Q9TQ97
    • Q9TQ98
    • Q9TQ99
    • Q9TQA0
    • Q9TQA1
    • Q9TQA2
    • Q9TQA3
    • Q9TQA4
    • Q9TQI9
    • Q9TQJ0
    • Q9TQJ1
    • Q9TQJ9
    • Q9TQK0
    • Q9TQK1
    • Q9TQK2
    • Q9TQK8
    • Q9TQK9
    • Q9TQL0
    • Q9TQL1
    • Q9TQL2
    • Q9TQL3
    • Q9TQL4
    • Q9UE04
    • Q9UE05
    • Q9UE06
    • Q9UE11

    Protein attributes for MICA Gene

    383 amino acids
    Molecular mass:
    42915 Da
    Quaternary structure:
    • Unlike classical MHC class I molecules, does not form a heterodimer with beta-2-microglobulin. Binds as a monomer to a KLRK1/NKG2D homodimer. KLRK1 forms a complex with HCST/DAP10 in which KLRK1 binds MICA while HCST acts as an adapter molecule which enables signal transduction. Interacts with PDIA6 on the surface of tumor cells, leading to disulfide bond reduction which is required for release of MICA from tumor cells. Interacts with human cytomegalovirus/HHV-5 protein UL142.
    • Recognized by antibodies in the sera of some organ transplant recipients and may be a target molecule in allograft rejection.

    Three dimensional structures from OCA and Proteopedia for MICA Gene

    Alternative splice isoforms for MICA Gene


neXtProt entry for MICA Gene

Proteomics data for MICA Gene at MOPED

Post-translational modifications for MICA Gene

  • N-glycosylated. Glycosylation is not essential for interaction with KLRK1/NKG2D but enhances complex formation.
  • Proteolytically cleaved and released from the cell surface of tumor cells which impairs KLRK1/NKG2D expression and T-cell activation.
  • Glycosylation at Asn 31, Asn 79, Asn 125, Asn 210, Asn 220, and Asn 261
  • Modification sites at PhosphoSitePlus

Other Protein References for MICA Gene

Antibody Products

No data available for DME Specific Peptides for MICA Gene

Domains & Families for MICA Gene

Gene Families for MICA Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 Ig-like C1-type (immunoglobulin-like) domain.
  • Belongs to the MHC class I family. MIC subfamily.
  • Contains 1 Ig-like C1-type (immunoglobulin-like) domain.
  • Belongs to the MHC class I family. MIC subfamily.
genes like me logo Genes that share domains with MICA: view

Function for MICA Gene

Molecular function for MICA Gene

GENATLAS Biochemistry:
MHC class I,chain-related gene A,43kDa,preferentially expressed in fibroblast and epithelial cell,with a repeat polymorphism in TM region possibly associated with Behcet disease,not involved in ankylosing spondylitis
UniProtKB/Swiss-Prot Function:
Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T-cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis.
UniProtKB/Swiss-Prot Induction:
By heat shock, by infection with human cytomegalovirus (HCMV), human adenovirus 5, M.tuberculosis and diarrheagenic E.coli, and by exposure to DNA damaging conditions such as high doses of ionizing radiation, chromatin-modifying treatments and inhibitors of DNA replication. The HCMV UL142 protein causes down-regulation of the full-length protein but not of the truncated MICA*008 allele.
genes like me logo Genes that share phenotypes with MICA: view

Animal Model Products

CRISPR Products

miRNA for MICA Gene

miRTarBase miRNAs that target MICA

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MICA Gene

Localization for MICA Gene

Subcellular locations from UniProtKB/Swiss-Prot for MICA Gene

Cell membrane; Single-pass type I membrane protein. Cytoplasm. Note=Expressed on the cell surface in gastric epithelium, endothelial cells and fibroblasts and in the cytoplasm in keratinocytes and monocytes. Infection with human adenovirus 5 suppresses cell surface expression due to the adenoviral E3-19K protein which causes retention in the endoplasmic reticulum. {ECO:0000269 PubMed:10363723, ECO:0000269 PubMed:18287244, ECO:0000269 PubMed:8901601}.

Subcellular locations from

Jensen Localization Image for MICA Gene COMPARTMENTS Subcellular localization image for MICA gene
Compartment Confidence
plasma membrane 3
extracellular 2
cytosol 1
endoplasmic reticulum 1
nucleus 1

No data available for Gene Ontology (GO) - Cellular Components for MICA Gene

Pathways & Interactions for MICA Gene

genes like me logo Genes that share pathways with MICA: view

Pathways by source for MICA Gene

Interacting Proteins for MICA Gene

Gene Ontology (GO) - Biological Process for MICA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006974 cellular response to DNA damage stimulus IDA 15995699
GO:0016032 viral process IEA --
GO:0042267 natural killer cell mediated cytotoxicity IDA 10426993
GO:0042742 defense response to bacterium IDA 11485740
GO:0045953 negative regulation of natural killer cell mediated cytotoxicity IMP 20068167
genes like me logo Genes that share ontologies with MICA: view

No data available for SIGNOR curated interactions for MICA Gene

Drugs & Compounds for MICA Gene

No Compound Related Data Available

Transcripts for MICA Gene

mRNA/cDNA for MICA Gene

(5) REFSEQ mRNAs :
(12) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MICA Gene

MHC class I polypeptide-related sequence A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MICA Gene

No ASD Table

Relevant External Links for MICA Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MICA Gene

mRNA expression in normal human tissues for MICA Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for MICA Gene

SOURCE GeneReport for Unigene cluster for MICA Gene Hs.130838

mRNA Expression by UniProt/SwissProt for MICA Gene

Tissue specificity: Widely expressed with the exception of the central nervous system where it is absent. Expressed predominantly in gastric epithelium and also in monocytes, keratinocytes, endothelial cells, fibroblasts and in the outer layer of Hassals corpuscles within the medulla of normal thymus. In skin, expressed mainly in the keratin layers, basal cells, ducts and follicles. Also expressed in many, but not all, epithelial tumors of lung, breast, kidney, ovary, prostate and colon. In thyomas, overexpressed in cortical and medullar epithelial cells. Tumors expressing MICA display increased levels of gamma delta T-cells.
genes like me logo Genes that share expression patterns with MICA: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Protein tissue co-expression partners for MICA Gene

Orthologs for MICA Gene

This gene was present in the common ancestor of chordates.

Orthologs for MICA Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia -- 36
  • 37 (a)
(Monodelphis domestica)
Mammalia MILL-LIKE 36
  • 26 (a)
(Mus musculus)
Mammalia Mill1 36
  • 26 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 18 (a)
(Pan troglodytes)
Mammalia MICB 36
  • 73 (a)
(Gallus gallus)
Aves -- 36
  • 28 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 22 (a)
(Danio rerio)
Actinopterygii arpc1a 36
  • 16 (a)
BX572619.1 36
  • 18 (a)
BX572619.2 36
  • 18 (a)
BX572619.3 36
  • 20 (a)
BX682558.1 36
  • 18 (a)
CABZ01031753.1 36
  • 17 (a)
CABZ01031754.1 36
  • 15 (a)
CR339041.1 36
  • 19 (a)
CR339041.2 36
  • 16 (a)
CU571323.1 36
  • 18 (a)
DARE-ZE*0601 36
  • 17 (a)
mhc1uba 36
  • 20 (a)
mhc1uca 36
  • 19 (a)
mhc1zaa 36
  • 17 (a)
mhc1zaa 36
  • 17 (a)
mhc1zba 36
  • 17 (a)
mhc1zca 36
  • 20 (a)
mhc1zea 36
  • 20 (a)
mhc1zfa 36
  • 18 (a)
si:ch211-147g22.1 36
  • 20 (a)
si:ch211-147g22.2 36
  • 17 (a)
si:ch211-147g22.3 36
  • 18 (a)
si:ch211-147g22.4 36
  • 23 (a)
si:dkey-52p2.4 36
  • 16 (a)
si:dkey-52p2.6 36
  • 18 (a)
si:dkey-52p2.7 36
  • 19 (a)
zgc:113060 36
  • 15 (a)
Species with no ortholog for MICA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MICA Gene

Gene Tree for MICA (if available)
Gene Tree for MICA (if available)

Paralogs for MICA Gene

Paralogs for MICA Gene

genes like me logo Genes that share paralogs with MICA: view

Variants for MICA Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for MICA Gene

The following alleles of MICA are known: MICA*001, MICA*002, MICA*004, MICA*005, MICA*006, MICA*007, MICA*008, MICA*009, MICA*010, MICA*011, MICA*012, MICA*013, MICA*014, MICA*015, MICA*016, MICA*017, MICA*018, MICA*019, MICA*020, MICA*022, MICA*023, MICA*024, MICA*025, MICA*026, MICA*027, MICA*028, MICA*029, MICA*030, MICA*031, MICA*032, MICA*033, MICA*034, MICA*035, MICA*036, MICA*037, MICA*038, MICA*039, MICA*040, MICA*041, MICA*042, MICA*043, MICA*044, MICA*045, MICA*046, MICA*047, MICA*048, MICA*049, MICA*050, MICA*051, MICA*052, MICA*053, MICA*054, MICA*055 and MICA*056. The sequence shown is that of MICA*001.

Sequence variations from dbSNP and Humsavar for MICA Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs9380254 - 31,410,558(+) TCTTC(A/C/G)TTATA reference, missense, utr-variant-5-prime
rs1063630 - 31,410,581(+) TGTCC(C/G/T)GGGAT reference, missense, utr-variant-5-prime
rs1051785 - 31,410,611(+) TTCTT(A/G)CTGAG reference, missense, utr-variant-5-prime
rs17200158 - 31,410,618(+) TGAGG(G/T)ACATC reference, missense, utr-variant-5-prime
rs1051786 - 31,410,648(+) GCGCT(A/C/G)TGACA reference, missense, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for MICA Gene

Variant ID Type Subtype PubMed ID
nsv428140 CNV Gain+Loss 18775914
esv690 CNV CNV 17122850
dgv1042e201 CNV Deletion 23290073
dgv1921e1 CNV Complex 17122850
esv33563 CNV Gain+Loss 17666407
nsv884319 CNV Gain 21882294
nsv517441 CNV Gain+Loss 19592680
nsv509125 CNV Insertion 20534489
dgv213e55 CNV Gain 17911159
dgv214e55 CNV Gain 17911159
dgv1926e1 CNV Complex 17122850
essv13266 CNV CNV 17122850
esv34063 CNV Loss 18971310
esv26480 CNV Loss 19812545
dgv6571n71 CNV Loss 21882294
dgv747n27 CNV Loss 19166990
dgv1098e199 CNV Deletion 23128226
esv2731822 CNV Deletion 23290073
esv3160 CNV Duplication 18987735
nsv511868 CNV Loss 21212237
nsv513736 CNV Insertion 21212237
esv2432528 CNV Deletion 19546169
dgv6573n71 CNV Loss 21882294
nsv435829 CNV Deletion 17901297
nsv10820 CNV Gain+Loss 18304495
nsv884353 CNV Gain 21882294
nsv884354 CNV Loss 21882294
dgv6574n71 CNV Gain 21882294
dgv6575n71 CNV Gain+Loss 21882294
nsv823497 CNV Loss 20364138
dgv215e55 CNV Loss 17911159
esv29968 CNV Gain 17803354
nsv441990 CNV CNV 18776908
dgv748n27 CNV Loss 19166990
nsv462854 CNV Gain 19166990
nsv818409 CNV Loss 17921354
nsv884382 CNV Loss 21882294
nsv437496 CNV Loss 16327808

Variation tolerance for MICA Gene

Residual Variation Intolerance Score: 98.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 18.71; 98.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MICA Gene

Human Gene Mutation Database (HGMD)

Disorders for MICA Gene

MalaCards: The human disease database

(17) MalaCards diseases for MICA Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
psoriatic arthritis
  • arthritis psoriatica
multiple myeloma
  • plasma cell neoplasm
  • multiple myeloma
behcet's disease
  • adamantiades-behcet disease
- elite association - COSMIC cancer census association via MalaCards
Search MICA in MalaCards View complete list of genes associated with diseases


  • Note=Anti-MICA antibodies and ligand shedding are involved in the progression of monoclonal gammopathy of undetermined significance (MGUS)to multiple myeloma.
  • Psoriasis 1 (PSORS1) [MIM:177900]: A common, chronic inflammatory disease of the skin with multifactorial etiology. It is characterized by red, scaly plaques usually found on the scalp, elbows and knees. These lesions are caused by abnormal keratinocyte proliferation and infiltration of inflammatory cells into the dermis and epidermis. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
  • Psoriatic arthritis (PSORAS) [MIM:607507]: An inflammatory, seronegative arthritis associated with psoriasis. It is a heterogeneous disorder ranging from a mild, non-destructive disease to a severe, progressive, erosive arthropathy. Five types of psoriatic arthritis have been defined: asymmetrical oligoarthritis characterized by primary involvement of the small joints of the fingers or toes; asymmetrical arthritis which involves the joints of the extremities; symmetrical polyarthritis characterized by a rheumatoid like pattern that can involve hands, wrists, ankles, and feet; arthritis mutilans, which is a rare but deforming and destructive condition; arthritis of the sacroiliac joints and spine (psoriatic spondylitis). {ECO:0000269 PubMed:10323458}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Relevant External Links for MICA

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with MICA: view

No data available for Genatlas for MICA Gene

Publications for MICA Gene

  1. The MICA-A9 triplet repeat polymorphism in the transmembrane region confers additional susceptibility to the development of psoriatic arthritis and is independent of the association of Cw*0602 in psoriasis. (PMID: 10323458) Gonzalez S. … Lopez-Larrea C. (Arthritis Rheum. 1999) 3 4 48 67
  2. A second lineage of mammalian major histocompatibility complex class I genes. (PMID: 8022771) Bahram S. … Spies T. (Proc. Natl. Acad. Sci. U.S.A. 1994) 2 3
  3. A genome-wide association study of rheumatoid arthritis without antibodies against citrullinated peptides. (PMID: 24532677) Bossini-Castillo L. … Koeleman B.P. (Ann. Rheum. Dis. 2015) 3
  4. Meta-analysis of the association between functional MICA-TM polymorphisms and systemic lupus erythematosus, rheumatoid arthritis and ankylosing spondylitis. (PMID: 25060517) Lee Y.H. … Song G.G. (Z Rheumatol 2015) 3
  5. MICA SNPs and the NKG2D system in virus-induced HCC. (PMID: 25270965) Goto K. … Kato N. (J. Gastroenterol. 2015) 3

Products for MICA Gene

Sources for MICA Gene