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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

MICA Gene

protein-coding GIFtS: 56
GCID: GC06P031373

MHC class I polypeptide-related sequence A

Explore 98 diseases affiliated with
MICA via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
MHC Class I Polypeptide-Related Sequence A¹ ²
PERB11.1¹ ² ³
MIC-A² ³
HLA Class I Antigen²
MHC Class I Chain-Related Protein A²
Stress Inducible Class I Homolog²

External Ids:	HGNC: 7090¹	Entrez Gene: 100507436²	Ensembl: ENSG00000204520⁷	OMIM: 600169⁵	UniProtKB: Q29983³

Export aliases for MICA gene to outside databases

Previous GC identifers: GC06P031425 GC06P031140 GC06P031471 GC06P031475 GC06P031479 GC06Pf31500 GC06Pc31510 GC06P031371 GC06P031370

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MICA:

MICA encodes the higly polymorphic MHC (HLA) class I chain-related gene A. The protein product is expressed on the cell

surface, although unlike canonical class I molecules does not seem to associate with beta-2-microglobulin. It is

thought that MICA functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma

delta T cells. Alternative splicing results in multiple transcript variants. (provided by RefSeq, Nov 2010)

UniProtKB/Swiss-Prot: MICA_HUMAN, Q29983

Function: Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by

gamma delta T-cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000006.11 NC_018917.1 NT_007592.15 NT_113891.2 NT_167249.1 NT_167246.1 NT_167248.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the MICA gene promoter:
c-Fos Sp1 AP-1 ATF-2 c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MICA promoter sequence

Search SABiosciences Chromatin IP Primers for MICA

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MICA

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.33 Ensembl cytogenetic band: 6p21.33 HGNC cytogenetic band: 6p21.3

MICA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MICA gene location

GeneLoc information about chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06P031373: view genomic region (about GC identifiers)

Start:	31,367,561 bp from pter	End:	31,433,586 bp from pter
Size:	66,026 bases	Orientation:	plus strand

3 alternative locations:

Chr6+,ALT_REF_LOCI_4 31,333,656-31,349,181

Chr6+,ALT_REF_LOCI_6 31,357,610-31,408,820

Chr6+,ALT_REF_LOCI_2 31,358,053-31,472,802

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MICA_HUMAN, Q29983 (See protein sequence)

Recommended Name: MHC class I polypeptide-related sequence A precursor

Size: 383 amino acids; 42915 Da

Subunit: Unlike classical MHC class I molecules, does not form a heterodimer with beta-2-microglobulin. Binds as a

monomer to a KLRK1/NKG2D homodimer. KLRK1 forms a complex with HCST/DAP10 in which KLRK1 binds MICA while HCST acts as

an adapter molecule which enables signal transduction. Interacts with PDIA6 on the surface of tumor cells, leading to

disulfide bond reduction which is required for release of MICA from tumor cells. Interacts with human

cytomegalovirus/HHV-5 protein UL142

Subcellular location: Cell membrane; Single-pass type I membrane protein. Cytoplasm. Note=Expressed on the cell surface

in gastric epithelium, endothelial cells and fibroblasts and in the cytoplasm in keratinocytes and monocytes.

Infection with human adenovirus 5 suppresses cell surface expression due to the adenoviral E3-19K protein which causes

retention in the endoplasmic reticulum

Miscellaneous: Recognized by antibodies in the sera of some organ transplant recipients and may be a target molecule in

allograft rejection

2 PDB 3D structures from and Proteopedia for MICA:

1B3J (3D)

1HYR (3D)

Secondary accessions: A8KQR0 A9LRW5 A9QVE0 B1VJF1 O60917 O60918 O60919 O60920 O60933 O77956 O78150

O78151 O78152 O78153 O97987 O97988 O97989 O97990 O97991 O97992 O97993 O97994 O97995 O98234 O98235

O98236 O98237 O98238 P79506 P79507 P79508 P79509 P79510 P79511 P79512 P79513 P79514 P79515 P79516

P79517 P79518 P79519 P79520 P79521 Q5C9P8 Q5XM81 Q70I48 Q70I49 Q7JFH9 Q7JFI0 Q7JFI1 Q7JFI2 Q7YQ98

Q861I1 Q95464 Q95HA2 Q95HD6 Q95HN4 Q95HN5 Q95HN6 Q95IB2 Q95IY7 Q99692 Q9BCR3 Q9BCR4 Q9BCR5 Q9BCR6

Q9BCR7 Q9BCR8 Q9BCR9 Q9BCS0 Q9BCS1 Q9BCS2 Q9BCS3 Q9BCS4 Q9BD20 Q9GIZ1 Q9GIZ2 Q9GIZ3 Q9GIZ4 Q9GIZ5

Q9GIZ6 Q9GJ01 Q9GJ02 Q9GJ03 Q9GJ04 Q9GJ05 Q9GJ06 Q9GJ07 Q9GJ08 Q9GJ09 Q9MY21 Q9TQ86 Q9TQ87 Q9TQ88

Q9TQ89 Q9TQ92 Q9TQ93 Q9TQ94 Q9TQ95 Q9TQ96 Q9TQ97 Q9TQ98 Q9TQ99 Q9TQA0 Q9TQA1 Q9TQA2 Q9TQA3 Q9TQA4

Q9TQI9 Q9TQJ0 Q9TQJ1 Q9TQJ9 Q9TQK0 Q9TQK1 Q9TQK2 Q9TQK8 Q9TQK9 Q9TQL0 Q9TQL1 Q9TQL2 Q9TQL3 Q9TQL4

Q9UE04 Q9UE05 Q9UE06 Q9UE11

Alternative splicing: 2 isoforms: Q29983-1 Q29983-2

Explore the universe of human proteins at neXtProt for MICA: NX_Q29983

Post-translational modifications:

N-glycosylated. Glycosylation is not essential for interaction with KLRK1/NKG2D but enhances complex formation¹

Proteolytically cleaved and released from the cell surface of tumor cells which impairs KLRK1/NKG2D expression and

T-cell activation¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q29983

MICA Protein expression data from MOPED and PaxDb: --

REFSEQ proteins (2 alternative transcripts):

NP_000238.1 NP_001170990.1

ENSEMBL proteins:

ENSP00000365396 ENSP00000365394 ENSP00000382125 ENSP00000402410 ENSP00000413079

Human Recombinant Protein Products:

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	GenScript Purified and Recombinant Proteins for MICA
	Novus Biologicals MICA Proteins Novus Biologicals MICA Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for MICA
	Uscn Proteins for MICA

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005615	extracellular space	IDA	18676862
GO:0005737	cytoplasm	IEA	--
GO:0005886	plasma membrane	--	--
GO:0005887	integral to plasma membrane	IDA	18676862
GO:0009986	cell surface	IDA	18676862

MICA for ontologies About GeneDecksing

MICA Antibody Products:

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	Uscn ELISAs and CLIAs for MICA

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

MICA for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR011162 MHC_I/II-like_Ag-recog

IPR013783 Ig-like_fold

IPR003597 Ig_C1-set

IPR007110 Ig-like_dom

IPR011161 MHC_I-like_Ag-recog

Graphical View of Domain Structure for InterPro Entry Q29983

ProtoNet protein and cluster: Q29983

1 Blocks protein family: IPB003597 Immunoglobulin C-type

UniProtKB/Swiss-Prot: MICA_HUMAN, Q29983

Similarity: Belongs to the MHC class I family. MIC subfamily

Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: MICA_HUMAN, Q29983

Function: Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by

gamma delta T-cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis

Induction: By heat shock, by infection with human cytomegalovirus (HCMV), human adenovirus 5, M.tuberculosis and

diarrheagenic E.coli, and by exposure to DNA damaging conditions such as high doses of ionizing radiation,

chromatin-modifying treatments and inhibitors of DNA replication. The HCMV UL142 protein causes down-regulation of the

full-length protein but not of the truncated MICA*008 allele

Genatlas biochemistry entry for MICA:

MHC class I,chain-related gene A,43kDa,preferentially expressed in fibroblast and epithelial cell,with a repeat

polymorphism in TM region possibly associated with Behcet disease,not involved in ankylosing spondylitis

miRNA Products:		miRTarBase miRNAs that target MICA: hsa-mir-373 (MIRT002551), hsa-mir-520b (MIRT004677)

		OriGene 3'-UTR Clone: MICA Browse MicroRNA Expression Plasmids
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		SwitchGear 3'UTR luciferase reporter plasmid: MICA 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Gene Editing
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		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MICA
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for MICA
		Search LifeMap BioReagents cell lines for MICA

In Situ Assay
Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for MICA

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0030881	NOT beta-2-microglobulin binding	IDA	8901601
GO:0046703	natural killer cell lectin-like receptor binding	IDA	11491531

MICA for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Immune System

Immune System

1.00

Adaptive Immune System

0.59

Natural killer cell mediated cytotoxicity

Natural killer cell mediated cytotoxicity

1.00

Cleavage of Alpha-1-Microglobulin

Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

0.30

Pathway sources
See GeneCards unified pathways
Show all pathways

1 Kegg Pathway (Kegg details for MICA):

Natural killer cell mediated cytotoxicity

MICA for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for MICA

3 Interacting proteins for MICA (Q29983^{2, 3}) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
LGALS3	P17931²^,³	MINT-8214455 MINT-8214577 I2D: score=1
KLRK1	P26718²^,³	MINT-8214603 I2D: score=4
KLRC4	O43908³	I2D: score=1

About this table

Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002223	stimulatory C-type lectin receptor signaling pathway	IDA	10426994
GO:0002418	immune response to tumor cell	IDA	10359807
GO:0006955	immune response	--	--
GO:0006974	response to DNA damage stimulus	IDA	15995699
GO:0009408	response to heat	IDA	8901601

MICA for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for MICA
Search CenterWatch for drugs/clinical trials and news about MICA

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MICA gene (2 alternative transcripts):

NM_000247.1 NM_001177519.1

Unigene Cluster for MICA:

MHC class I polypeptide-related sequence A

Hs.130838 [show with all ESTs]

Unigene Representative Sequence: NR_036523

7 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000376222(uc003rxz.1 uc021yun.1) ENST00000484008 ENST00000364810(uc021yuo.1)

ENST00000399172 ENST00000421350 ENST00000468458 ENST00000449934(uc003ntk.1)

miRNA Products:		OriGene 3'-UTR Clone: MICA Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MICA
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Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Clone Products:		OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MICA OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: MICA (NM_014632)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MICA
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MICA

Additional cDNA sequence:

AB506764.1 AK094237.1 AK225393.1 AK299135.1 AK310028.1 AK311667.1 AY204547.1 AY750850.1

BC016929.1 L14848.1 NR_036523.1 NR_036524.1

20 DOTS entries:

DT.121310192 DT.413253 DT.97798115 DT.100813116 DT.121310373 DT.100813115 DT.40210949 DT.100837934

DT.121310550 DT.121310691 DT.121310518 DT.95280037 DT.121310783 DT.408185 DT.100773245 DT.92003125

DT.95085360 DT.92434498 DT.91911313 DT.97844162

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MICA expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTCTGCTGT

About this image

MICA expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

PureStem™ progenitor SK17 (Embryonic Progenitor Cell)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Genevestigator expression for MICA

SOURCE GeneReport for Unigene cluster: Hs.130838

UniProtKB/Swiss-Prot: MICA_HUMAN, Q29983

Tissue specificity: Widely expressed with the exception of the central nervous system where it is absent. Expressed

predominantly in gastric epithelium and also in monocytes, keratinocytes, endothelial cells, fibroblasts and in the

outer layer of Hassal's corpuscles within the medulla of normal thymus. In skin, expressed mainly in the keratin

layers, basal cells, ducts and follicles. Also expressed in many, but not all, epithelial tumors of lung, breast,

kidney, ovary, prostate and colon. In thyomas, overexpressed in cortical and medullar epithelial cells. Tumors

expressing MICA display increased levels of gamma delta T-cells

SABiosciences Custom PCR Arrays for MICA

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MICA

In Situ
Assay Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for MICA

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for MICA gene from 3/7 species (see all 7) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	F1NM79_CHICK⁶ -- (see all 15)	--	29(a) 28(a) (see all 15)	many ↔ many many ↔ many (see all 15)	16(40458-41204) Un(62829135-62830402)
lizard (Anolis carolinensis)	Reptilia	-- -- (see all 25)	--	31(a) 31(a) (see all 25)	many ↔ many many ↔ many (see all 25)	AAWZ02039289(783-2823) AAWZ02040156(3915-5955)
zebrafish (Danio rerio)	Actinopterygii	zgc:136614⁶ si:ch211-287j19.6⁶ (see all 7)	si:ch211-287j19.6 (see all 7)	20(a) 19(a) (see all 7)	many ↔ many many ↔ many (see all 7)	1(47637895-47648897) 1(47613228-47619236)

ENSEMBL Gene Tree for MICA (if available)
TreeFam Gene Tree for MICA (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for MICA gene

MICB² AZGP1²

18/94 SIMAP similar genes for MICA using alignment to 65 protein entries: MICA_HUMAN (see all proteins) (see all similar genes):

PERB11.1 MICB DKFZp762B162 HLA-A*0201V3 PTPNS1 SIRPB1

HLA-G2.2 Cw HFE CD1E HLA-Cw* HLA-G

HLA C* HLA-A*02 HLA-A24AK MHC HLA-B* HLA-A*33

MICA for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

UniProtKB/Swiss-Prot: MICA_HUMAN, Q29983

Polymorphism: The following alleles of MICA are known: MICA*001, MICA*002, MICA*004, MICA*005, MICA*006, MICA*007,

MICA*008, MICA*009, MICA*010, MICA*011, MICA*012, MICA*013, MICA*014, MICA*015, MICA*016, MICA*017, MICA*018,

MICA*019, MICA*020, MICA*022, MICA*023, MICA*024, MICA*025, MICA*026, MICA*027, MICA*028, MICA*029, MICA*030,

MICA*031, MICA*032, MICA*033, MICA*034, MICA*035, MICA*036, MICA*037, MICA*038, MICA*039, MICA*040, MICA*041,

MICA*042, MICA*043, MICA*044, MICA*045, MICA*046, MICA*047, MICA*048, MICA*049, MICA*050, MICA*051, MICA*052,

MICA*053, MICA*054, MICA*055 and MICA*056. The sequence shown is that of MICA*001

SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs185452057^1,2		--	31366500(+)	`CTTAAA/CCTTTT`	1	--	us2k¹		0	--	--	--	--
rs189764172^1,2		--	31366506(+)	`CTTTTA/TAAAAA`	1	--	us2k¹		0	--	--	--	--
rs56129118^1,2	C	--	31366568(+)	`TTACTC/TTTTTT`	1	--	us2k¹		0	--	--	--	--
rs2596542^1,2	C,F,H,	--	31366595(-)	`TACACG/AATAAA`	1	--	us2k¹ tfbs³		17		NS EA WA CSA NA	2235
rs2428475^1,2	C,F,H,	--	31366622(-)	`GATTTT/CAATCG`	1	--	us2k¹		17		NS EA WA CSA NA	2237
rs111765073^1,2		--	31366696(+)	`GAACAT/CTTTAA`	1	--	us2k¹		2		CSA WA	119
rs139439524^1,2		--	31366737(+)	`TCCCAA/GTAAGA`	1	--	us2k¹		0	--	--	--	--
rs184241361^1,2		--	31366749(+)	`GATTTA/TAAAAT`	1	--	us2k¹		0	--	--	--	--
rs78048235^1,2	C,	--	31366825(+)	`TGCCCG/AGGAGA`	1	--	us2k¹		1		WA	2
rs145495927^1,2		--	31366835(+)	`ACACAC/TCCTGA`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for MICA (31367561 - 31433586 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 28 variations for MICA
15/27 CNVs (see all 27): 81316 8509 3601 51892 8510 2625 34518 64473 7564 31276 93623 34623 32782 53986 38638
1 Indel: 43716
Human Gene Mutation Database (HGMD): MICA

Locus Specific Mutation Databases (LSDB): MICA

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MICA

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

MICA for disorders About GeneDecksing

OMIM gene information: 600169 OMIM disorders: --

UniProtKB/Swiss-Prot: MICA_HUMAN, Q29983

Note=Anti-MICA antibodies and ligand shedding are involved in the progression of monoclonal gammopathy of

undetermined significance (MGUS)to multiple myeloma

Genetic variations in MICA may be a cause of susceptibility to psoriasis type 1 (PSORS1) [MIM:177900].

Psoriasis is a common, chronic inflammatory disease of the skin with multifactorial etiology. It is characterized by

red, scaly plaques usually found on the scalp, elbows and knees. These lesions are caused by abnormal keratinocyte

proliferation and infiltration of inflammatory cells into the dermis and epidermis

Genetic variation in MICA is a cause of susceptibility to psoriatic arthritis (PSORAS) [MIM:607507]. PSORAS is

an inflammatory, seronegative arthritis associated with psoriasis. It is a heterogeneous disorder ranging from a mild,

non-destructive disease to a severe, progressive, erosive arthropathy. Five types of psoriatic arthritis have been

defined: asymmetrical oligoarthritis characterized by primary involvement of the small joints of the fingers or toes;

asymmetrical arthritis which involves the joints of the extremities; symmetrical polyarthritis characterized by a

rheumatoidlike pattern that can involve hands, wrists, ankles, and feet; arthritis mutilans, which is a rare but

deforming and destructive condition; arthritis of the sacroiliac joints and spine (psoriatic spondylitis)

20/98 diseases for MICA (see all 98): About MalaCards

monoclonal gammopathy of undetermined significance stiff-person syndrome mixed connective tissue disease connective tissue disease

graft versus host disease sclerosing cholangitis primary sclerosing cholangitis oral submucous fibrosis

familial mediterranean fever type 1 diabetes mellitus alopecia areata idiopathic pulmonary fibrosis

ankylosing spondylitis cholangitis oral squamous cell carcinoma cleft lip

systemic lupus erythematosus squamous cell carcinoma cleft palate lupus erythematosus

2 diseases from the University of Copenhagen DISEASES database for MICA:

Celiac disease Addison's disease

Genetic Association Database (GAD): MICA
Human Genome Epidemiology (HuGE) Navigator: MICA (178 documents)

Export disorders for MICA gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for MICA gene, integrated from 9 sources (see all 363):
(articles sorted by number of sources associating them with MICA)

Utopia: connect your pdf to the dynamic
world of online information

The MICA-A9 triplet repeat polymorphism in the transmembrane region confers additional susceptibility to the development of psoriatic arthritis and is independent of the association of Cw*0602 in psoriasis. (PubMed id 10323458)^{1, 2, 4} Gonzalez S.... Lopez-Larrea C. (1999)
A second lineage of mammalian major histocompatibility complex class I genes. (PubMed id 8022771)^{1, 2, 3} Bahram S.... Spies T. (1994)
NKG2D ligand MICA is retained in the cis-Golgi appara tus by human cytomegalovirus protein UL142. (PubMed id 19793804)^{1, 2} Ashiru O....Wills M.R. (2009)
Adenovirus E3/19K promotes evasion of NK cell recognition by intracellular sequestration of the NKG2D ligands MICA and MICB. (PubMed id 18287244)^{1, 2} McSharry B.P.... Wilkinson G.W. (2008)
MHC class I chain-related protein A antibodies and shedding are associated with the progression of multiple myeloma. (PubMed id 18202175)^{1, 2} Jinushi M.... Dranoff G. (2008)
In vivo expression pattern of MICA and MICB and its relevance to auto-immunity and cancer. (PubMed id 17565371)^{1, 2} Schrambach S.... Bahram S. (2007)
Disulphide-isomerase-enabled shedding of tumour-associated NKG2D ligands. (PubMed id 17495932)^{1, 2} Kaiser B.K.... Spies T. (2007)
Down-regulation of the NKG2D ligand MICA by the human cytomegalovirus glycoprotein UL142. (PubMed id 16750166)^{1, 2} Chalupny N.J.... Cosman D. (2006)
The identification of three novel MICA alleles by sequence-based typing. (PubMed id 16634869)^{1, 2} Quiroga I.... Fuggle S.V. (2006)
[Polymorphism of short tandem repeat of exon 5 of MHC class-I chain related gene A and association with nasopharyngeal carcinoma in a southern Chinese population] (PubMed id 15952123)^{1, 4} Tian W....Cao Y. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 100507436	HGNC: 7090	Ensembl:ENSG00000204520	euGenes: HUgn100507436	ECgene: MICA	Kegg: 100507436
H-InvDB: MICA

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for MICA	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for MICA	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for MICA gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for MICA gene:
Search GeneIP for patents involving MICA

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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