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Aliases for MIB2 Gene

Aliases for MIB2 Gene

  • Mindbomb E3 Ubiquitin Protein Ligase 2 2 3
  • Zinc Finger ZZ Type With Ankyrin Repeat Domain Protein 1 3 4
  • Zinc Finger, ZZ Type With Ankyrin Repeat Domain 1 2 3
  • Putative NF-Kappa-B-Activating Protein 002N 3 4
  • Novel Zinc Finger Protein 3 4
  • Mind Bomb Homolog 2 3 4
  • Skeletrophin 3 4
  • Novelzin 3 4
  • ZZANK1 3 4
  • Mindbomb Homolog 2 (Drosophila) 2
  • Mindbomb Homolog 2 3
  • EC 63
  • EC 6.3.2.- 4
  • EC 6.3.2 63
  • ZZZ5 3
  • SKD 4

External Ids for MIB2 Gene

Previous HGNC Symbols for MIB2 Gene

  • ZZANK1

Previous GeneCards Identifiers for MIB2 Gene

  • GC01P9N0043
  • GC01P001540
  • GC01P000824
  • GC01P001550

Summaries for MIB2 Gene

GeneCards Summary for MIB2 Gene

MIB2 (Mindbomb E3 Ubiquitin Protein Ligase 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Downstream signaling events of B Cell Receptor (BCR). GO annotations related to this gene include actin binding and ubiquitin-protein transferase activity. An important paralog of this gene is ANKDD1B.

UniProtKB/Swiss-Prot for MIB2 Gene

  • E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors (By similarity).

Gene Wiki entry for MIB2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIB2 Gene

Genomics for MIB2 Gene

Regulatory Elements for MIB2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MIB2 Gene

1,614,975 bp from pter
1,630,610 bp from pter
15,636 bases
Plus strand

Genomic View for MIB2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIB2 Gene

Proteins for MIB2 Gene

  • Protein details for MIB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    E3 ubiquitin-protein ligase MIB2
    Protein Accession:
    Secondary Accessions:
    • A2AGM5
    • A2AGM6
    • B3KV93
    • B3KVF4
    • B3KXY1
    • B4DZ57
    • E9PGU1
    • E9PHQ1
    • F8WA73
    • J3KNZ7
    • Q7Z437
    • Q8IY62
    • Q8N786
    • Q8N897
    • Q8N8R2
    • Q8N911
    • Q8NB36
    • Q8NCY1
    • Q8NG59
    • Q8NG60
    • Q8NG61
    • Q8NI59
    • Q8WYN1

    Protein attributes for MIB2 Gene

    1013 amino acids
    Molecular mass:
    109939 Da
    Quaternary structure:
    • Interacts with actin monomer.
    • Sequence=AAH16490.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB82979.1; Type=Frameshift; Positions=193, 205; Evidence={ECO:0000305}; Sequence=BAC03707.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC04646.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC04752.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC04952.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for MIB2 Gene

neXtProt entry for MIB2 Gene

Proteomics data for MIB2 Gene at MOPED

Post-translational modifications for MIB2 Gene

  • Ubiquitinated. Possibly via autoubiquitination (By similarity).
  • Ubiquitination at Lys 427 and Lys 842
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for MIB2 (Mind Bomb 2/MIB2)

Domains & Families for MIB2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 MIB/HERC2 domains.
  • Contains 9 ANK repeats.
  • Contains 2 MIB/HERC2 domains.
  • Contains 9 ANK repeats.
  • Contains 2 RING-type zinc fingers.
  • Contains 1 ZZ-type zinc finger.
genes like me logo Genes that share domains with MIB2: view

Function for MIB2 Gene

Molecular function for MIB2 Gene

UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors (By similarity).
UniProtKB/Swiss-Prot Induction:
Down-regulated in many primary skin melanomas. Treatment with a demethylating agent, 5-aza-2-deoxycytidine, restores expression, suggesting that down-regulation is the result of methylation of the gene.

Enzyme Numbers (IUBMB) for MIB2 Gene

Gene Ontology (GO) - Molecular Function for MIB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0004842 ubiquitin-protein transferase activity IBA --
GO:0004871 signal transducer activity IMP 12761501
GO:0005515 protein binding IPI 21903422
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with MIB2: view
genes like me logo Genes that share phenotypes with MIB2: view

Animal Models for MIB2 Gene

MGI Knock Outs for MIB2:

No data available for Transcription Factor Targets and HOMER Transcription for MIB2 Gene

Localization for MIB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIB2 Gene

Cytoplasm. Endosome. Note=Colocalizes with endosomal compartments.

Subcellular locations from

Jensen Localization Image for MIB2 Gene COMPARTMENTS Subcellular localization image for MIB2 gene
Compartment Confidence
endosome 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for MIB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex IEA --
GO:0005737 cytoplasm IBA --
GO:0005769 early endosome IEA --
genes like me logo Genes that share ontologies with MIB2: view

Pathways & Interactions for MIB2 Gene

genes like me logo Genes that share pathways with MIB2: view

Pathways by source for MIB2 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

UniProtKB/Swiss-Prot Q96AX9-MIB2_HUMAN

  • Pathway: Protein modification; protein ubiquitination

SIGNOR curated interactions for MIB2 Gene


Gene Ontology (GO) - Biological Process for MIB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007219 Notch signaling pathway IEA --
GO:0016567 protein ubiquitination IEA --
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IMP 12761501
genes like me logo Genes that share ontologies with MIB2: view

Drugs & Compounds for MIB2 Gene

No Compound Related Data Available

Transcripts for MIB2 Gene

Unigene Clusters for MIB2 Gene

Mindbomb E3 ubiquitin protein ligase 2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MIB2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIB2 Gene

No ASD Table

Relevant External Links for MIB2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIB2 Gene

mRNA expression in normal human tissues for MIB2 Gene

Protein differential expression in normal tissues from HIPED for MIB2 Gene

This gene is overexpressed in Pancreas (24.2), Bone (18.2), Heart (10.8), and Liver, secretome (10.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MIB2 Gene

SOURCE GeneReport for Unigene cluster for MIB2 Gene Hs.135805

mRNA Expression by UniProt/SwissProt for MIB2 Gene

Tissue specificity: Expressed in skeletal muscle, and to a lesser extent in heart, brain and kidney.
genes like me logo Genes that share expression patterns with MIB2: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein tissue co-expression partners for MIB2 Gene

Orthologs for MIB2 Gene

This gene was present in the common ancestor of animals.

Orthologs for MIB2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MIB2 35
  • 86.99 (n)
  • 89.66 (a)
MIB2 36
  • 89 (a)
(Canis familiaris)
Mammalia MIB2 35
  • 89.39 (n)
  • 93.3 (a)
MIB2 36
  • 91 (a)
(Mus musculus)
Mammalia Mib2 35
  • 85.49 (n)
  • 92.95 (a)
Mib2 16
Mib2 36
  • 93 (a)
(Pan troglodytes)
Mammalia MIB2 35
  • 93.31 (n)
  • 90.92 (a)
(Rattus norvegicus)
Mammalia Mib2 35
  • 85.1 (n)
  • 92.43 (a)
(Monodelphis domestica)
Mammalia MIB2 36
  • 72 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 68 (a)
-- 36
  • 64 (a)
(Gallus gallus)
Aves MIB2 35
  • 67.16 (n)
  • 69.26 (a)
MIB2 36
  • 69 (a)
(Anolis carolinensis)
Reptilia MIB2 36
  • 81 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mib2 35
  • 63.82 (n)
  • 67.72 (a)
(Danio rerio)
Actinopterygii mib2 35
  • 66.9 (n)
  • 62.7 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008851 35
  • 56.26 (n)
  • 45.31 (a)
fruit fly
(Drosophila melanogaster)
Insecta mib2 35
  • 53.3 (n)
  • 45.21 (a)
mib2 36
  • 40 (a)
Species with no ortholog for MIB2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIB2 Gene

Gene Tree for MIB2 (if available)
Gene Tree for MIB2 (if available)

Paralogs for MIB2 Gene

Paralogs for MIB2 Gene

genes like me logo Genes that share paralogs with MIB2: view

Variants for MIB2 Gene

Sequence variations from dbSNP and Humsavar for MIB2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs12066 -- 1,613,974(+) gtggc(A/G)aaaac upstream-variant-2KB
rs1127870 -- 1,613,797(-) GATTC(C/G)CTGTG upstream-variant-2KB
rs3935032 -- 1,628,814(+) CCCCT(C/T)CAGTG intron-variant
rs4648611 -- 1,615,322(-) GGTCC(C/T)AGAGA upstream-variant-2KB, utr-variant-5-prime
rs4648781 -- 1,614,505(-) gggcc(A/G)ggcga upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIB2 Gene

Variant ID Type Subtype PubMed ID
nsv10161 CNV Gain+Loss 18304495
dgv10n71 CNV Loss 21882294
dgv20n71 CNV Loss 21882294
dgv34n71 CNV Loss 21882294
nsv871837 CNV Loss 21882294
nsv871690 CNV Gain 21882294
dgv9e1 CNV Complex 17122850
dgv43n71 CNV Loss 21882294
dgv44n71 CNV Gain+Loss 21882294
nsv871954 CNV Loss 21882294
nsv871540 CNV Gain 21882294
dgv45n71 CNV Loss 21882294
nsv870847 CNV Loss 21882294
nsv871940 CNV Loss 21882294
dgv46n71 CNV Loss 21882294
nsv822031 CNV Loss 20364138
esv2661270 CNV Deletion 23128226
esv2748585 CNV Deletion 23290073
esv2659399 CNV Deletion 23128226

Variation tolerance for MIB2 Gene

Residual Variation Intolerance Score: 85.42% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.26; 85.06% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MIB2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MIB2 Gene

Disorders for MIB2 Gene

Relevant External Links for MIB2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with MIB2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIB2 Gene

Publications for MIB2 Gene

  1. Drosophila mind bomb2 is required for maintaining muscle integrity and survival. (PMID: 17954605) Nguyen H.T. … Frasch M. (J. Cell Biol. 2007) 23 67
  2. A ubiquitin ligase, skeletrophin, is a negative regulator of melanoma invasion. (PMID: 16715130) Takeuchi T. … Ohtsuki Y. (Oncogene 2006) 23 67
  3. Skeletrophin, a novel ubiquitin ligase to the intracellular region of Jagged-2, is aberrantly expressed in multiple myeloma. (PMID: 15920166) Takeuchi T. … Ohtsuki Y. (Am. J. Pathol. 2005) 23 67
  4. Skeletrophin, a novel RING molecule controlled by the chromatin remodeling complex, is downregulated in malignant melanoma. (PMID: 15869411) Takeuchi T. … Ohtsuki Y. (DNA Cell Biol. 2005) 23 67
  5. Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. (PMID: 12761501) Matsuda A. … Sugano S. (Oncogene 2003) 2 67

Products for MIB2 Gene

Sources for MIB2 Gene

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