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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MIB2 Gene

protein-coding   GIFtS: 51
GCID: GC01P001540

mindbomb E3 ubiquitin protein ligase 2

(Previous names: zinc finger, ZZ type with ankyrin repeat domain 1, mindbomb...)
(Previous symbol: ZZANK1)
 Explore 4 diseases affiliated with
MIB2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MIB2    

Aliases
for MIB2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Mindbomb E3 Ubiquitin Protein Ligase 21 2     Mindbomb Homolog 2 (Drosophila)1
ZZANK11 2 3     E3 Ubiquitin-Protein Ligase MIB22
ZZZ51 2     Mindbomb Homolog 22
Skeletrophin3     Novelzin3
Zinc Finger, ZZ Type With Ankyrin Repeat Domain 11 2     EC 6.3.2.-3
Mind Bomb Homolog 22 3     Novelzin3
Novel Zinc Finger Protein2 3     SKD3
Putative NF-Kappa-B-Activating Protein 002N2 3     Skeletrophin3
Zinc Finger ZZ Type With Ankyrin Repeat Domain Protein 12 3     EC 6.3.28
FLJ397871     EC 6.3.2.138

External Ids:    HGNC: 305771   Entrez Gene: 1426782   Ensembl: ENSG000001975307   OMIM: 6111415   UniProtKB: Q96AX93   
ORGUL members:         
NONCODE:n409082    

Export aliases for MIB2 gene to outside databases

Previous GC identifers: GC01P9N0043 GC01P000824


Summaries
for MIB2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: MIB2_HUMAN, Q96AX9
Function: E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch
proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta,
leading to endocytosis of Delta receptors (By similarity)

Gene Wiki entry for MIB2


Genomic Views
for MIB2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004350.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MIB2 gene promoter:
         c-Fos   Max1   AP-1   JunB   Fra-1   FosB   GATA-1   AREB6   JunD   c-Jun   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for MIB2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MIB2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.33   Ensembl cytogenetic band:  1p36.33   HGNC cytogenetic band: 1p36.33

MIB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MIB2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P001540:  view genomic region     (about GC identifiers)

Start:
 1,550,795 bp from pter      End:
 1,565,990 bp from pter
Size:
 15,196 bases      Orientation:
 plus strand

Proteins
for MIB2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MIB2_HUMAN, Q96AX9 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase MIB2  
Size: 1013 amino acids; 109939 Da
Subunit: Interacts with actin monomer
Subcellular location: Cytoplasm. Endosome. Note=Colocalizes with endosomal compartments
Sequence caution: Sequence=AAH16490.1; Type=Erroneous initiation; Sequence=BAB82979.1; Type=Frameshift; Positions=193,
205; Sequence=BAC03707.1; Type=Erroneous initiation; Sequence=BAC04646.1; Type=Erroneous initiation;
Sequence=BAC04752.1; Type=Erroneous initiation; Sequence=BAC04952.1; Type=Erroneous initiation;
Secondary accessions: A2AGM5 A2AGM6 B3KV93 B3KVF4 B3KXY1 Q7Z437 Q8IY62 Q8N786 Q8N897 Q8N8R2 Q8N911
Q8NB36 Q8NCY1 Q8NG59 Q8NG60 Q8NG61 Q8NI59 Q8WYN1
Alternative splicing: 10 isoforms:  Q96AX9-1   Q96AX9-2   Q96AX9-3   Q96AX9-4   Q96AX9-5   Q96AX9-10   Q96AX9-7   Q96AX9-8   
Q96AX9-9   Q96AX9-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MIB2: NX_Q96AX9

Post-translational modifications:

  • Ubiquitinated. Possibly via autoubiquitination (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q96AX9

    • 4/12 DME Specific Peptides for MIB2 (Q96AX9) (see all 12)
     AVQRGFL  RGMRWKC  RRMKKCI  RVVRGVDW 

    MIB2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (5 alternative transcripts): 
    NP_001164157.1  NP_001164158.1  NP_001164159.1  NP_001164160.1  NP_543151.2  

    ENSEMBL proteins: 
     ENSP00000428660   ENSP00000348081   ENSP00000428264   ENSP00000426103   ENSP00000426007  
     ENSP00000420935   ENSP00000424615   ENSP00000423221   ENSP00000367984   ENSP00000426865  
     ENSP00000426128   ENSP00000426603   ENSP00000367980   ENSP00000425032   ENSP00000427680  
     ENSP00000463504   ENSP00000464106   ENSP00000349741   ENSP00000353713   ENSP00000367982  
    Reactome Protein details: Q96AX9
    Human Recombinant Protein Products: 
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    Uscn Proteins for MIB2

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000151ubiquitin ligase complex ----
    GO:0005768endosome IEA--
    GO:0005769early endosome ----


    MIB2 for ontologies           About GeneDecksing



    MIB2 Antibody Products: 
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    Assay Products for MIB2: 
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    Uscn ELISAs and CLIAs for MIB2

    Protein Domains /
    Families
    for MIB2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MIB2 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR001841 Znf_RING
     IPR013083 Znf_RING/FYVE/PHD
     IPR002110 Ankyrin_rpt
     IPR010606 Mib_Herc2
     IPR020683 Ankyrin_rpt-contain_dom

    Graphical View of Domain Structure for InterPro Entry Q96AX9

    ProtoNet protein and cluster: Q96AX9

    2 Blocks protein families:
    IPB000433 Zn-finger
    IPB001841 Zn-finger


    UniProtKB/Swiss-Prot: MIB2_HUMAN, Q96AX9
    Similarity: Contains 9 ANK repeats
    Similarity: Contains 2 MIB/HERC2 domains
    Similarity: Contains 2 RING-type zinc fingers
    Similarity: Contains 1 ZZ-type zinc finger


    Function
    for MIB2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: MIB2_HUMAN, Q96AX9
    Function: E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch
    proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta,
    leading to endocytosis of Delta receptors (By similarity)
    Induction: Down-regulated in many primary skin melanomas. Treatment with a demethylating agent, 5'-aza-2-deoxycytidine,
    restores expression, suggesting that down-regulation is the result of methylation of the gene

    Enzyme Numbers (IUBMB): EC 6.3.2.-1 EC 6.3.22 EC 6.3.2.132

    miRNA
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    Inhib. RNA
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    Gene Editing
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    Clone
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    Cell Line
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    In Situ Assay
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         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MIB2

    Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
    GO:0004842ubiquitin-protein ligase activity IEA--
    GO:0004871signal transducer activity IMP12761501
    GO:0005515protein binding IPI--
    GO:0008270zinc ion binding IEA--


    MIB2 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Mib2tm1Art for MIB2
         9 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Mib2):
     behavior/neurological  growth/size  homeostasis/metabolism  limbs/digits/tail  mortality/aging 
     nervous system  normal  skeleton  vision/eye 

    MIB2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for MIB2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Signaling by NOTCH1 t(7 9)(NOTCH1:M1580_K2555) Translocation Mutant
    8/10 pathways (see all 10)
    		Signaling by NOTCH1 PEST Domain Mutants in Cancer1.00
    		Signaling by NOTCH11.00
    		Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer1.00
    		Signaling by NOTCH1 t(7 9)(NOTCH1:M1580_K2555) Translocation Mutant1.00
    		Signaling by NOTCH1 in Cancer1.00
    		Constitutive Signaling by NOTCH1 PEST Domain Mutants0.79
    		Signaling by NOTCH1 HD Domain Mutants in Cancer1.00
    		Signaling by NOTCH0.77
    2NOTCH2 Activation and Transmission of Signal to the Nucleus
    		NOTCH2 Activation and Transmission of Signal to the Nucleus1.00
    		Constitutive Signaling by NOTCH1 HD Domain Mutants0.62
    		Signaling by NOTCH21.00
    		Activated NOTCH1 Transmits Signal to the Nucleus0.58
    3Disease
    		Disease1.00
    4Signaling by GPCR
    		Signal Transduction0.56

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5/16        Reactome Pathways for MIB2 (see all 16)
        Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
    FBXW7 Mutants and NOTCH1 in Cancer
    Signaling by NOTCH1 HD Domain Mutants in Cancer
    Signaling by NOTCH1 in Cancer
    Disease


    UniProtKB/Swiss-Prot: MIB2_HUMAN, Q96AX9
    Pathway: Protein modification; protein ubiquitination


    MIB2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MIB2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    5/17 Interacting proteins for MIB2 (Q96AX91, 3 ENSP000003480814) via UniProtKB, MINT, STRING, and/or I2D (see all 17)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    TBK1Q9UHD21, 3EBI-2130249,EBI-1383470 I2D: score=1 
    MAP3K7O433183, ENSP000003583354I2D: score=2 STRING: ENSP00000358335
    UBE2UQ5VVX93, ENSP000003601164I2D: score=2 STRING: ENSP00000360116
    BCL10O959993, ENSP000002710154I2D: score=2 STRING: ENSP00000271015
    ACTA1P681333I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction ----
    GO:0007219Notch signaling pathway IEA--
    GO:0016567protein ubiquitination ----
    GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cascade IMP12761501


    MIB2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for MIB2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MIB2
    Search CenterWatch for drugs/clinical trials and news about MIB2 

    Transcripts
    for MIB2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MIB2 gene (5 alternative transcripts): 
    NM_001170686.1  NM_001170687.1  NM_001170688.1  NM_001170689.1  NM_080875.2  

    Unigene Clusters for MIB2:

    Mindbomb E3 ubiquitin protein ligase 2
    Hs.135805  [show with all ESTs], Hs.593430  [show with all ESTs]
    Unigene Representative Sequences: NM_080875, BC035078
    18/35 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 35):
    ENST00000520777 ENST00000355826 ENST00000518681 ENST00000505820 ENST00000479659
    ENST00000489635 ENST00000511502 ENST00000477990(uc021oet.1) ENST00000514363
    ENST00000487053(uc001agl.2 uc001agm.3) ENST00000502470 ENST00000378712
    ENST00000507082 ENST00000463492 ENST00000510793 ENST00000504599(uc010nyq.2)
    ENST00000507229 ENST00000503789

    miRNA
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    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MIB2 (see all 4)
    OriGene shRNA RFP: MIB2
    OriGene siRNA: MIB2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MIB2
    Clone
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    Primer
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    Additional cDNA sequence: BC035078.1 

    24/28 DOTS entries (see all 28):

    DT.101970850  DT.427135  DT.100030554  DT.101984676  DT.100787496  DT.101969062  DT.95298171  DT.97762267 
    DT.100787493  DT.95185010  DT.100030560  DT.121450211  DT.97823806  DT.100030559  DT.65286733  DT.95185024 
    DT.121450231  DT.95185027  DT.100787491  DT.65285549  DT.95185013  DT.121450160  DT.121450195  DT.91760184 

    24/48 AceView cDNA sequences (see all 48):

    BQ440174 AI637776 BF197236 AV653361 BV178518 BG152598 BX509465 BE250256 
    BE858181 AI360951 W61347 AI223236 CB051127 BU849243 AI739664 AI620113 
    AI628802 AI312107 AI761594 BE467928 BE326445 BM925490 AW014171 BE222279 

    GeneLoc Exon Structure


    Expression
    for MIB2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MIB2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CGCCCCCTGC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See MIB2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MIB2

    SOURCE GeneReport for Unigene clusters: Hs.135805 Hs.593430

    UniProtKB/Swiss-Prot: MIB2_HUMAN, Q96AX9
    Tissue specificity: Expressed in skeletal muscle, and to a lesser extent in heart, brain and kidney

        SABiosciences Expression via Pathway-Focused PCR Array including MIB2: 
              Ubiquitin Ligases in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MIB2

    Orthologs
    for MIB2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for MIB2 gene from 5/15 species (see all 15)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves MIB21 mindbomb homolog 2 (Drosophila) 67.12(n)
    69.37(a)    		   419408  NM_001006301.1  NP_001006301.1 
    lizard
    (Anolis carolinensis)    		 Reptilia MIB26
    		 --
    		 78(a)
    		 1 ↔ 1
    		 AAWZ02036979(3652-5691)
    zebrafish
    (Danio rerio)    		 Actinopterygii mib21 mind bomb 2 66.77(n)
    62.44(a)    		   560887  NM_001079678.1  NP_001073146.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta mib21 mind bomb 2 51.34(n)
    44.14(a)    		   35170  NM_136089.2  NP_609933.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea mib-16
    		 Protein MIB-1
    		 18(a)
    		 1 ↔ 1
    		 III(11286236-11290600)


    ENSEMBL Gene Tree for MIB2 (if available)
    TreeFam Gene Tree for MIB2 (if available) 

    Paralogs
    for MIB2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MIB2 gene
    ANKDD1A2  MIB12  ANKDD1B2  ANKRD62  
    8 SIMAP similar genes for MIB2 using alignment to 17 protein entries:     MIB2_HUMAN (see all proteins):
    ANKRD44    ANK2    ANKRD6    PPP1R12A    ANK3    IkBa
    RAI14    MIB1

    MIB2 for paralogs           About GeneDecksing



    Genomic Variants
    for MIB2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/269 NCBI SNPs in MIB2 are shown (see all 269)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs94424301,2
    		C,F,--1548801(-) AGGGCG/AGATCA 5 -- us2k15Minor allele frequency- A:0.20NA WA CSA 10
    rs75198631,2
    		C,--1548896(-) ctatgC/Gtgttt 5 -- us2k13Minor allele frequency- G:0.11NA WA 122
    rs1870367141,2
    		--1548899(+) CAGCAC/TAGCCC 5 -- us2k10--------
    rs1461619301,2
    		--1548975(+) CGGCAC/TGGTGG 5 -- us2k10--------
    rs1401242361,2
    		--1549007(+) ACTCAC/GGAGGC 5 -- us2k10--------
    rs753779811,2
    		C,--1549066(+) CAAGAC/TAGTGC 5 -- us2k11Minor allele frequency- T:0.50WA 2
    rs1165545871,2
    		F,--1549069(+) GATAGT/AGCCAC 5 -- us2k11Minor allele frequency- A:0.04WA 118
    rs1910804031,2
    		--1549099(+) CAGAGA/CAAGAC 5 -- us2k10--------
    rs345011551,2
    		C,F,--1549149(-) CCTAAG/ACNNNN 5 -- us2k14Minor allele frequency- A:0.20NA EA 244
    rs751094771,2
    		C,F,--1549166(+) TTTTTC/TGTTTA 5 -- us2k11Minor allele frequency- T:0.02WA 118

    HapMap Linkage Disequilibrium report for MIB2 (1550795 - 1565990 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 4 variations for MIB2
         4 CNVs: 2042 2295 30362 3276

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    Disorders / Diseases
    for MIB2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MIB2 for disorders           About GeneDecksing

    OMIM gene information: 611141    OMIM disorders: --

    4 diseases for MIB2:    About MalaCards
    skin melanoma    multiple myeloma    myeloma    melanoma

    4 Novoseek disease relationships for MIB2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nevi 59 3 14507647 (1), 16715130 (1)
    melanoma 43 16 16715130 (8), 14507647 (3), 15869411 (3)
    tumors 4.65 1 16715130 (1)
    cancer 0 1 16715130 (1)


    Export disorders for MIB2 gene to outside databases

    Publications
    for MIB2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MIB2 gene, integrated from 9 sources (see all 22):
    (articles sorted by number of sources associating them with MIB2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. (PubMed id 12761501)1, 2, 3 Matsuda A....Sugano S. (2003)
    2. Down-regulation of a novel actin-binding molecule, skeletrophin, in malignant melanoma. (PubMed id 14507647)1, 2, 9 Takeuchi T....Ohtsuki Y. (2003)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. A ubiquitin ligase, skeletrophin, is a negative regulator of melanoma invasion. (PubMed id 16715130)1, 9 Takeuchi T....Ohtsuki Y. (2006)
    6. Skeletrophin, a novel ubiquitin ligase to the intracellular region of Jagged-2, is aberrantly expressed in multiple myeloma. (PubMed id 15920166)1, 9 Takeuchi T....Ohtsuki Y. (2005)
    7. Skeletrophin, a novel RING molecule controlled by the chromatin remodeling complex, is downregulated in malignant melanoma. (PubMed id 15869411)1, 9 Takeuchi T....Ohtsuki Y. (2005)
    8. Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. (PubMed id 21903422)1 Li S....Dorf M.E. (2011)
    9. The E3 ubiquitin ligase mind bomb-2 (MIB2) protein co ntrols B-cell CLL/lymphoma 10 (BCL10)-dependent NF-I_B activation. (PubMed id 21896478)1 Stempin C.C....Redecke V. (2011)
    10. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)

    External Searches for MIB2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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    Genome Databases showing MIB2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 142678 HGNC: 30577 AceView: LOC142678.1 Ensembl:ENSG00000197530 euGenes: HUgn142678
    ECgene: MIB2 H-InvDB: MIB2

    Other Databases showing MIB2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing MIB2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MIB2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MIB2 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for MIB2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MIB2 gene:
    Search GeneIP for patents involving MIB2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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