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Aliases for MIB1 Gene

Aliases for MIB1 Gene

  • Mindbomb E3 Ubiquitin Protein Ligase 1 2 3
  • DIP1 3 4 6
  • Zinc Finger ZZ Type With Ankyrin Repeat Domain Protein 2 3 4
  • DAPK-Interacting Protein 1 3 4
  • KIAA1323 4 6
  • ZZANK2 3 4
  • DIP-1 3 4
  • LVNC7 3 6
  • MIB 3 6
  • E3 Ubiquitin-Protein Ligase MIB1 3
  • Mindbomb Homolog 1 (Drosophila) 2
  • Ubiquitin Ligase Mind Bomb 3
  • Mind Bomb Homolog 1 4
  • EC 6.3.2.- 4
  • EC 6.3.2 63
  • ZZZ6 3

External Ids for MIB1 Gene

Previous GeneCards Identifiers for MIB1 Gene

  • GC18P017574
  • GC18P017575
  • GC18P019321
  • GC18P016168
  • GC18P019284

Summaries for MIB1 Gene

Entrez Gene Summary for MIB1 Gene

  • This gene encodes a protein containing multiple ankyrin repeats and RING finger domains that functions as an E3 ubiquitin ligase. The encoded protein positively regulates Notch signaling by ubiquitinating the Notch receptors, thereby facilitating their endocytosis. This protein may also promote the ubiquitination and degradation of death-associated protein kinase 1 (DAPK1). [provided by RefSeq, Jun 2013]

GeneCards Summary for MIB1 Gene

MIB1 (Mindbomb E3 Ubiquitin Protein Ligase 1) is a Protein Coding gene. Diseases associated with MIB1 include left ventricular noncompaction 7 and left ventricular noncompaction. Among its related pathways are Signaling by GPCR and Disease. GO annotations related to this gene include ubiquitin-protein transferase activity. An important paralog of this gene is ANKDD1B.

UniProtKB/Swiss-Prot for MIB1 Gene

  • E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis (By similarity). Involved in ubiquitination of centriolar satellite CEP131, CEP290 and PCM1 proteins and hence inhibits primary cilium formation in proliferating cells. Mediates Lys-63-linked polyubiquitination of TBK1, which probably participates in kinase activation.

Gene Wiki entry for MIB1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIB1 Gene

Genomics for MIB1 Gene

Regulatory Elements for MIB1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MIB1 Gene

Start:
21,704,957 bp from pter
End:
21,870,957 bp from pter
Size:
166,001 bases
Orientation:
Plus strand

Genomic View for MIB1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIB1 Gene

Proteins for MIB1 Gene

  • Protein details for MIB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86YT6-MIB1_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase MIB1
    Protein Accession:
    Q86YT6
    Secondary Accessions:
    • B0YJ38
    • Q2TB37
    • Q68D01
    • Q6YI51
    • Q8NBY0
    • Q8TCB5
    • Q8TCL7
    • Q9P2M3

    Protein attributes for MIB1 Gene

    Size:
    1006 amino acids
    Molecular mass:
    110136 Da
    Quaternary structure:
    • Interacts with CEP131 and PCM1.
    Miscellaneous:
    • In epilepsy brain tissue, levels of expression are increased in the cytoplasm and microsomal fractions (endoplasmic reticulum)
    SequenceCaution:
    • Sequence=AAH22403.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAN18023.1; Type=Frameshift; Positions=3; Evidence={ECO:0000305}; Sequence=BAC11439.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for MIB1 Gene

Proteomics data for MIB1 Gene at MOPED

Post-translational modifications for MIB1 Gene

  • Ubiquitinated; possibly via autoubiquitination (By similarity). Ubiquitinated; this modification is inhibited in response to cellular stress, such as ultraviolet light (UV) radiation or heat shock.
  • Ubiquitination at Lys28, Lys79, Lys202, Lys222, Lys313, Lys368, Lys399, Lys421, Lys437, Lys452, Lys485, Lys618, Lys691, Lys726, Lys735, Lys750, Lys772, Lys787, Lys854, Lys917, Lys938, and Lys949
  • Modification sites at PhosphoSitePlus

Other Protein References for MIB1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for MIB1 (Mind Bomb 1/MIB1)
  • Cell Signaling Technology (CST) Antibodies for MIB1 (MIB1)

Domains for MIB1 Gene

Gene Families for MIB1 Gene

HGNC:
  • ANKRD :Ankyrin repeat domain containing
  • ZZZ :Zinc fingers, ZZ-type

Suggested Antigen Peptide Sequences for MIB1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86YT6

UniProtKB/Swiss-Prot:

MIB1_HUMAN :
  • Q86YT6
Domain:
  • Contains 2 MIB/HERC2 domains.
Similarity:
  • Contains 9 ANK repeats.
  • Contains 3 RING-type zinc fingers.
  • Contains 1 ZZ-type zinc finger.
genes like me logo Genes that share domains with MIB1: view

Function for MIB1 Gene

Molecular function for MIB1 Gene

UniProtKB/Swiss-Prot Function: E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis (By similarity). Involved in ubiquitination of centriolar satellite CEP131, CEP290 and PCM1 proteins and hence inhibits primary cilium formation in proliferating cells. Mediates Lys-63-linked polyubiquitination of TBK1, which probably participates in kinase activation.

Enzyme Numbers (IUBMB) for MIB1 Gene

Gene Ontology (GO) - Molecular Function for MIB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IBA --
GO:0005515 protein binding IPI 21903422
GO:0008270 zinc ion binding IEA --
GO:0016874 ligase activity IEA --
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with MIB1: view
genes like me logo Genes that share phenotypes with MIB1: view

Animal Models for MIB1 Gene

MGI Knock Outs for MIB1:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MIB1

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for MIB1 Gene

Localization for MIB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIB1 Gene

Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Cell membrane. Note=Localizes to the plasma membrane (By similarity). According to PubMed:15048887, it is mitochondrial, however such localization remains unclear. Displaced from centriolar satellites in response to cellular stress, such as ultraviolet light (UV) radiation or heat shock. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MIB1 Gene COMPARTMENTS Subcellular localization image for MIB1 gene
Compartment Confidence
cytoskeleton 5
cytosol 4
nucleus 4
plasma membrane 4
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for MIB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0005813 centrosome IDA 21399614
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IEA --
GO:0014069 postsynaptic density IEA --
genes like me logo Genes that share ontologies with MIB1: view

Pathways for MIB1 Gene

genes like me logo Genes that share pathways with MIB1: view

Pathways by source for MIB1 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

UniProtKB/Swiss-Prot Q86YT6-MIB1_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for MIB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001568 blood vessel development IEA --
GO:0001701 in utero embryonic development IEA --
GO:0001756 somitogenesis IEA --
GO:0001841 neural tube formation IEA --
GO:0001947 heart looping IEA --
genes like me logo Genes that share ontologies with MIB1: view

Compounds for MIB1 Gene

(4) HMDB Compounds for MIB1 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine monophosphate
  • 5'-AMP
61-19-8
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
Phosphoric acid
  • acide phosphorique (FRENCH)
7664-38-2
Pyrophosphate
  • (4-)Diphosphoric acid ion
14000-31-8
genes like me logo Genes that share compounds with MIB1: view

Transcripts for MIB1 Gene

Unigene Clusters for MIB1 Gene

Mindbomb E3 ubiquitin protein ligase 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MIB1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for MIB1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIB1 Gene

No ASD Table

Relevant External Links for MIB1 Gene

GeneLoc Exon Structure for
MIB1
ECgene alternative splicing isoforms for
MIB1

Expression for MIB1 Gene

mRNA expression in normal human tissues for MIB1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MIB1 Gene

SOURCE GeneReport for Unigene cluster for MIB1 Gene Hs.140903

mRNA Expression by UniProt/SwissProt for MIB1 Gene

Q86YT6-MIB1_HUMAN
Tissue specificity: Widely expressed at low level. Expressed at higher level in spinal cord, ovary, whole brain, and all specific brain regions examined.
genes like me logo Genes that share expressions with MIB1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for MIB1 Gene

Orthologs for MIB1 Gene

This gene was present in the common ancestor of animals.

Orthologs for MIB1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MIB1 35
  • 99.44 (n)
  • 99.6 (a)
MIB1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MIB1 35
  • 91.75 (n)
  • 99.6 (a)
MIB1 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MIB1 35
  • 94 (n)
  • 98.01 (a)
MIB1 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mib1 35
  • 91.12 (n)
  • 99.3 (a)
Mib1 16
Mib1 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MIB1 36
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MIB1 36
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mib1 35
  • 91.12 (n)
  • 99.2 (a)
chicken
(Gallus gallus)
Aves MIB1 35
  • 86.28 (n)
  • 99.01 (a)
MIB1 36
  • 99 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MIB1 36
  • 99 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.16510 35
tropical clawed frog
(Silurana tropicalis)
Amphibia mib1 35
  • 82.21 (n)
  • 96.42 (a)
Str.15052 35
zebrafish
(Danio rerio)
Actinopterygii mib 35
  • 76.69 (n)
  • 94.32 (a)
mib 36
  • 92 (a)
OneToMany
MIB1 (1 of 2) 36
  • 89 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011932 35
  • 61.24 (n)
  • 68.92 (a)
fruit fly
(Drosophila melanogaster)
Insecta mib1 35
  • 66.14 (n)
  • 73.87 (a)
mib1 36
  • 58 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7778 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 61 (a)
OneToOne
Species with no ortholog for MIB1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIB1 Gene

ENSEMBL:
Gene Tree for MIB1 (if available)
TreeFam:
Gene Tree for MIB1 (if available)

Paralogs for MIB1 Gene

Paralogs for MIB1 Gene

Selected SIMAP similar genes for MIB1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MIB1: view

Variants for MIB1 Gene

Sequence variations from dbSNP and Humsavar for MIB1 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs7449 -- 21,867,032(+) ACCCT(C/G)CTCAT utr-variant-3-prime
rs11905 -- 21,868,465(+) TGTCT(A/G)TTCAT utr-variant-3-prime
rs14062 -- 21,870,342(+) AGCAT(A/G)AGTGT utr-variant-3-prime
rs948563 -- 21,759,968(-) AACAA(C/G)TTAGA intron-variant
rs948564 -- 21,750,884(-) AGCAT(A/G)TATTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MIB1 Gene

Variant ID Type Subtype PubMed ID
nsv909448 CNV Gain 21882294
nsv909450 CNV Gain 21882294
esv2716852 CNV Deletion 23290073
nsv2222 CNV Insertion 18451855
dgv3395n71 CNV Loss 21882294
nsv909453 CNV Loss 21882294

Relevant External Links for MIB1 Gene

HapMap Linkage Disequilibrium report
MIB1
Human Gene Mutation Database (HGMD)
MIB1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MIB1 Gene

Disorders for MIB1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for MIB1 Gene including...

Search for MIB1 Gene in MalaCards »

(1) OMIM Diseases for MIB1 Gene (608677)

UniProtKB/Swiss-Prot

MIB1_HUMAN
  • Left ventricular non-compaction 7 (LVNC7) [MIM:615092]: A disease due to an arrest of myocardial morphogenesis. It is characterized by a hypertrophic left ventricle with deep trabeculations and with poor systolic function, with or without associated left ventricular dilation. In some cases, it is associated with other congenital heart anomalies. {ECO:0000269 PubMed:23314057}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(4) University of Copenhagen DISEASES for MIB1 Gene

(3) Novoseek inferred disease relationships for MIB1 Gene

Disease -log(P) Hits PubMed IDs
tumors 13.2 2
carcinoma 1.98 2
necrosis 0 2
genes like me logo Genes that share disorders with MIB1: view

Publications for MIB1 Gene

  1. A death-associated protein kinase (DAPK)-interacting protein, DIP-1, is an E3 ubiquitin ligase that promotes tumor necrosis factor-induced apoptosis and regulates the cellular levels of DAPK. (PMID: 12351649) Jin Y. … Gallagher P.J. (J. Biol. Chem. 2002) 3 23
  2. Mind bomb 1 regulation of cFLIP interactions. (PMID: 19710364) Zhang L. … Gallagher P.J. (Am. J. Physiol., Cell Physiol. 2009) 3 23
  3. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T. … Ohara O. (DNA Res. 2000) 3 4
  4. Mind bomb is a ubiquitin ligase that is essential for efficient activation of Notch signaling by Delta. (PMID: 12530964) Itoh M. … Chitnis A.B. (Dev. Cell 2003) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for MIB1 Gene

  • Addgene plasmids for MIB1

Sources for MIB1 Gene

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