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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MIB1 Gene

protein-coding   GIFtS: 59
GCID: GC18P019284

mindbomb E3 ubiquitin protein ligase 1

(Previous name: mindbomb homolog 1 (Drosophila) )
 Explore 19 diseases affiliated with
MIB1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MIB1    

Aliases
for MIB1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Mindbomb E3 Ubiquitin Protein Ligase 11 2     DAPK-Interacting Protein 12 3
DIP-11 2 3     Mindbomb Homolog 1 (Drosophila)1
ZZANK21 2 3     E3 Ubiquitin-Protein Ligase MIB12
MIB1 2     Mindbomb Homolog 12
ZZZ61 2     Ubiquitin Ligase Mind Bomb2
KIAA13231 3     Ubiquitin Ligase Protein MIB12
Mind Bomb Homolog 12 3     EC 6.3.2.-3
Zinc Finger ZZ Type With Ankyrin Repeat Domain Protein 22 3     EC 6.3.28
DIP12 3     

External Ids:    HGNC: 210861   Entrez Gene: 575342   Ensembl: ENSG000001017527   OMIM: 6086775   UniProtKB: Q86YT63   

Export aliases for MIB1 gene to outside databases

Previous GC identifers: GC18P017574 GC18P017575 GC18P019321 GC18P016168


Summaries
for MIB1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: MIB1_HUMAN, Q86YT6
Function: E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch
proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta,
leading to endocytosis of Delta receptors. Probably mediates ubiquitination and subsequent proteasomal degradation of
DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis (By similarity). Mediates
'Lys-63'-linked polyubiquitination of TBK1, which probably participates in kinase activation

Gene Wiki entry for MIB1


Genomic Views
for MIB1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000018.9  NC_018929.1  NT_010966.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MIB1 gene promoter:
         Pax-5   p53   p300   YY1   c-Ets-1   STAT3   Msx-1   Pax-4a   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MIB1 promoter sequence
   Search SABiosciences Chromatin IP Primers for MIB1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MIB1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q11.2   Ensembl cytogenetic band:  18q11.2   HGNC cytogenetic band: 18q11.2

MIB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MIB1 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18P019284:  view genomic region     (about GC identifiers)

Start:
 19,284,918 bp from pter      End:
 19,450,918 bp from pter
Size:
 166,001 bases      Orientation:
 plus strand

Proteins
for MIB1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MIB1_HUMAN, Q86YT6 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase MIB1  
Size: 1006 amino acids; 110136 Da
Subcellular location: Cytoplasm. Cell membrane (By similarity). Note=Localizes to the plasma membrane (By similarity).
According to PubMed:15048887, it is mitochondrial, however such localization remains unclear
Miscellaneous: In epilepsy brain tissue, levels of expression are increased in the cytoplasm and microsomal fractions
(endoplasmic reticulum)
Sequence caution: Sequence=AAH22403.1; Type=Erroneous initiation; Sequence=AAN18023.1; Type=Frameshift; Positions=3;
Sequence=BAC11439.1; Type=Erroneous initiation;
Secondary accessions: B0YJ38 Q2TB37 Q68D01 Q6YI51 Q8NBY0 Q8TCB5 Q8TCL7 Q9P2M3

Explore the universe of human proteins at neXtProt for MIB1: NX_Q86YT6

Post-translational modifications:

  • Ubiquitinated. Possibly via autoubiquitination (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q86YT6

    • 4/24 DME Specific Peptides for MIB1 (Q86YT6) (see all 24)
     TSWTYNP  LAKCHKEK  QAASQNGH  RVVRGVDW 

    MIB1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_065825.1  
    ENSEMBL proteins: 
     ENSP00000261537  
    Reactome Protein details: Q86YT6
    Human Recombinant Protein Products: 
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    Browse Sino Biological Recombinant Proteins
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    Uscn Proteins for MIB1

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005813centrosome IDA--
    GO:0005829cytosol ----
    GO:0005886plasma membrane IDA--
    GO:0014069postsynaptic density ----
    GO:0031410cytoplasmic vesicle IEA--


    MIB1 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for MIB1

    Protein Domains /
    Families
    for MIB1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MIB1 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR001841 Znf_RING
     IPR013083 Znf_RING/FYVE/PHD
     IPR002110 Ankyrin_rpt
     IPR010606 Mib_Herc2
     IPR020683 Ankyrin_rpt-contain_dom

    Graphical View of Domain Structure for InterPro Entry Q86YT6

    ProtoNet protein and cluster: Q86YT6

    3 Blocks protein families:
    IPB000433 Zn-finger
    IPB001841 Zn-finger
    IPB002110 Ankyrin repeat signature


    UniProtKB/Swiss-Prot: MIB1_HUMAN, Q86YT6
    Similarity: Contains 9 ANK repeats
    Similarity: Contains 2 MIB/HERC2 domains
    Similarity: Contains 3 RING-type zinc fingers
    Similarity: Contains 1 ZZ-type zinc finger


    Function
    for MIB1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: MIB1_HUMAN, Q86YT6
    Function: E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch
    proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta,
    leading to endocytosis of Delta receptors. Probably mediates ubiquitination and subsequent proteasomal degradation of
    DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis (By similarity). Mediates
    'Lys-63'-linked polyubiquitination of TBK1, which probably participates in kinase activation

    Enzyme Numbers (IUBMB): EC 6.3.2.-1 EC 6.3.22

    miRNA
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    hsa-mir-210 (MIRT003176)

    OriGene 3'-UTR Clone: MIB1
    Browse MicroRNA Expression Plasmids
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    8/112 QIAGEN miScript miRNA Assays for microRNAs that regulate MIB1 (see all 112):
    hsa-miR-576-3p hsa-miR-520e hsa-miR-607 hsa-miR-411 hsa-miR-15a hsa-miR-200a hsa-miR-3653 hsa-miR-3074-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MIB1 (see all 7)
    OriGene shRNA RFP: MIB1
    Browse OriGene siRNA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MIB1

    Gene Editing
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    Clone
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    Search LifeMap BioReagents cell lines for MIB1

    In Situ Assay
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity IEA--
    GO:0005515protein binding IPI--
    GO:0008270zinc ion binding IEA--


    MIB1 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-outs for MIB1: Mib1tm1Kong Mib1tm1Art
         15/16 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Mib1) (see all 16):
     cardiovascular system  cellular  craniofacial  digestive/alimentary  embryogenesis 
     endocrine/exocrine gland  growth/size  hematopoietic system  homeostasis/metabolism  integument 
     limbs/digits/tail  mortality/aging  nervous system  no phenotypic analysis  normal 

    MIB1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for MIB1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Signaling by NOTCH1 t(7 9)(NOTCH1:M1580_K2555) Translocation Mutant
    8/10 pathways (see all 10)
    		Signaling by NOTCH1 PEST Domain Mutants in Cancer1.00
    		Signaling by NOTCH11.00
    		Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer1.00
    		Signaling by NOTCH1 t(7 9)(NOTCH1:M1580_K2555) Translocation Mutant1.00
    		Signaling by NOTCH1 in Cancer1.00
    		Constitutive Signaling by NOTCH1 PEST Domain Mutants0.79
    		Signaling by NOTCH1 HD Domain Mutants in Cancer1.00
    		Signaling by NOTCH0.77
    2NOTCH2 Activation and Transmission of Signal to the Nucleus
    		NOTCH2 Activation and Transmission of Signal to the Nucleus1.00
    		Constitutive Signaling by NOTCH1 HD Domain Mutants0.62
    		Signaling by NOTCH21.00
    		Activated NOTCH1 Transmits Signal to the Nucleus0.58
    3Wnt / Hedgehog / Notch
    		Wnt / Hedgehog / Notch1.00
    4Protein Stability
    		Protein Stability1.00
    5Disease
    		Disease1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    2 Cell Signaling Technology (CST) Pathways for MIB1
        Wnt / Hedgehog / Notch
    Protein Stability

    1 BioSystems Pathway for MIB1 
        Notch signaling pathway

    5/16        Reactome Pathways for MIB1 (see all 16)
        Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
    FBXW7 Mutants and NOTCH1 in Cancer
    Signaling by NOTCH1 HD Domain Mutants in Cancer
    Signaling by NOTCH1 in Cancer
    Disease


    UniProtKB/Swiss-Prot: MIB1_HUMAN, Q86YT6
    Pathway: Protein modification; protein ubiquitination


    MIB1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MIB1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/33 Interacting proteins for MIB1 (Q86YT61, 2, 3 ENSP000002615374) via UniProtKB, MINT, STRING, and/or I2D (see all 33)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    SNX5Q9Y5X32, 3, ENSP000003669884MINT-2841402 I2D: score=2 STRING: ENSP00000366988
    TBK1Q9UHD21, 3, ENSP000003299674EBI-2129148,EBI-1383470 I2D: score=1 STRING: ENSP00000329967
    UBE2D2P628373, ENSP000003817174I2D: score=2 STRING: ENSP00000381717
    UBE2D3P610773, ENSP000003497224I2D: score=2 STRING: ENSP00000349722
    UBE2NP610883, ENSP000003161764I2D: score=2 STRING: ENSP00000316176
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001568blood vessel development IEA--
    GO:0001701in utero embryonic development IEA--
    GO:0001756somitogenesis IEA--
    GO:0001841neural tube formation IEA--
    GO:0001947heart looping IEA--


    MIB1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for MIB1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MIB1

    4 HMDB Compounds for MIB1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--
    Search CenterWatch for drugs/clinical trials and news about MIB1 

    Transcripts
    for MIB1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MIB1 gene: 
    NM_020774.2  

    Unigene Clusters for MIB1:

    Mindbomb E3 ubiquitin protein ligase 1
    Hs.140903  [show with all ESTs], Hs.658808  [show with all ESTs]
    Unigene Representative Sequences: NM_020774, BX648566
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000578646 ENST00000261537(uc002ktp.3 uc002ktq.3) ENST00000577749
    ENST00000578260

    miRNA
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    8/112 QIAGEN miScript miRNA Assays for microRNAs that regulate MIB1 (see all 112):
    hsa-miR-576-3p hsa-miR-520e hsa-miR-607 hsa-miR-411 hsa-miR-15a hsa-miR-200a hsa-miR-3653 hsa-miR-3074-3p
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    Inhib. RNA
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    Primer
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    Additional cDNA sequence: 

    AF086463.1 AK123912.1 BX648566.1 

    12 DOTS entries:

    DT.454347  DT.101981882  DT.95264194  DT.101985456  DT.121088044  DT.422365  DT.100792997  DT.121088041 
    DT.204878  DT.75112943  DT.97827295  DT.100792996 

    24/288 AceView cDNA sequences (see all 288):

    W88972 BX489289 AA215348 AW150307 BU192771 AX746883 AI240596 AV727020 
    AA972891 AA806186 AA243594 AW770441 AA578562 AI863550 AW572357 N44566 
    BM903940 AI275750 AK091266 AA935386 AL713705 CR617658 AY149908 CR749635 

    GeneLoc Exon Structure


    Expression
    for MIB1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MIB1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TAAGAATTAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See MIB1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MIB1

    SOURCE GeneReport for Unigene clusters: Hs.140903 Hs.658808

    UniProtKB/Swiss-Prot: MIB1_HUMAN, Q86YT6
    Tissue specificity: Widely expressed at low level. Expressed at higher level in spinal cord, ovary, whole brain, and
    all specific brain regions examined

        SABiosciences Expression via Pathway-Focused PCR Arrays including MIB1: 
              Ubiquitination (Ubiquitylation) Pathway in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MIB1

    Orthologs
    for MIB1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for MIB1 gene from 6/20 species (see all 20)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Mib11 , 5 mindbomb homolog 1 (Drosophila)1, 5 91.12(n)1
    99.3(a)1    		   18 (5.35 cM)5
    2251641  NM_144860.21  NP_659109.21 
     107255485 
    chicken
    (Gallus gallus)    		 Aves MIB11 mindbomb homolog 1 (Drosophila) 86.28(n)
    99.01(a)    		   421069  XM_419157.3  XP_419157.2 
    lizard
    (Anolis carolinensis)    		 Reptilia --
    --
    		 --
    		 99(a)
    93(a)
    		 1 ↔ 1
    possible ortholog
    		 4(38877466-38891931)
    4(38839670-38876103)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.165102 Xenopus laevis transcribed sequence with weak similarity more 79.47(n)    CA987003.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii mib2 mind bomb 80.33(n)   352910  AF537301.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta mib11 mind bomb 1 66.03(n)
    73.54(a)    		   39750  NM_140569.2  NP_648826.2 


    ENSEMBL Gene Tree for MIB1 (if available)
    TreeFam Gene Tree for MIB1 (if available) 

    Paralogs
    for MIB1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MIB1 gene
    ANKDD1A2  MIB22  ANKDD1B2  ANKRD62  
    6 SIMAP similar genes for MIB1 using alignment to 2 protein entries:     MIB1_HUMAN (see all proteins):
    PPP1R12A    CDKN2C    PSMD10    MIB2    DKFZp761E1322    MTPN

    MIB1 for paralogs           About GeneDecksing



    Genomic Variants
    for MIB1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1840 NCBI SNPs in MIB1 are shown (see all 1840)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 18 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1161129171,2
    		F,--19319578(+) TTTATC/TCCTGG 1 -- us2k12Minor allele frequency- T:0.12WA NA 238
    rs285155041,2
    		F,--19319637(+) GTTCGA/TGACCA 1 -- us2k11Minor allele frequency- T:0.05WA 118
    rs1134899811,2
    		C,--19319885(+) AAAACAA/-AACAA 1 -- us2k11Minor allele frequency- -:0.00CSA 2
    rs456108401,2
    		C,--19319891(+) AAAAAA/CAAAAC 1 -- us2k12Minor allele frequency- C:0.07NS NA 40
    rs2013790551,2
    		--19319899(+) AACAA-/CAACAA 1 -- us2k10--------
    rs118747351,2
    		C,F,A,H,--19319902(+) AACAAC/AAAAAA 1 -- us2k11Minor allele frequency- A:0.50NA 4
    rs1997368821,2
    		--19319902(+) AACAA-/CAAAAA 1 -- us2k10--------
    rs1487335781,2
    		--19319935(+) TTTCAA/GTACAT 1 -- us2k10--------
    rs1920166231,2
    		--19320110(+) ACCCTA/GTGCAG 1 -- us2k10--------
    rs1417447971,2
    		--19320200(+) TTAGGA/GACTGA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for MIB1 (19284918 - 19450918 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for MIB1: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MIB1
    DNA2.0 Custom Variant and Variant Library Synthesis for MIB1

    Disorders / Diseases
    for MIB1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MIB1 for disorders           About GeneDecksing

    OMIM gene information: 608677    OMIM disorders: --

    19 diseases for MIB1:    About MalaCards
    dysembryoplastic neuroepithelial tumor    temporal lobe epilepsy    soft tissue sarcoma    cavernous malformation
    mucoepidermoid carcinoma    squamous cell carcinoma    gallbladder carcinoma    ependymoma
    hepatitis c    sarcoma    carcinoma    meningioma
    breast carcinoma    lung cancer    prostate cancer    breast cancer
    hepatitis    prostatitis    neuronitis

    5 diseases from the University of Copenhagen DISEASES database for MIB1:
    Carcinoma     Meningioma     Breast cancer     Adenoma
    Malignant glioma

    3 Novoseek disease relationships for MIB1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 13.2 2 10072173 (1), 12351649 (1)
    carcinoma 1.98 2 7792271 (1), 10738715 (1)
    necrosis 0 2 10072173 (1), 12351649 (1)


    Export disorders for MIB1 gene to outside databases

    Publications
    for MIB1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MIB1 gene, integrated from 9 sources (see all 57):
    (articles sorted by number of sources associating them with MIB1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. (PubMed id 21903422)1, 2 Li S....Dorf M.E. (2011)
    2. Death-associated protein kinase expression in human temporal lobe epilepsy. (PubMed id 15048887)1, 2 Henshall D.C....Simon R.P. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Mind bomb is a ubiquitin ligase that is essential for efficient activation of Notch signaling by Delta. (PubMed id 12530964)1, 2 Itoh M.... Chitnis A.B. (2003)
    6. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2 Nagase T.... Ohara O. (2000)
    7. A death-associated protein kinase (DAPK)-interacting protein, DIP-1, is an E3 ubiquitin ligase that promotes tumor necrosis factor-induced apoptosis and regulates the cellular levels of DAPK. (PubMed id 12351649)1, 9 Jin Y....Gallagher P.J. (2002)
    8. Mind bomb 1 regulation of cFLIP interactions. (PubMed id 19710364)1, 9 Zhang L. and Gallagher P.J. (2009)
    9. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    10. Clinicopathologic correlation of vitamin D receptor ex pression with retinoid X receptor and MIB-1 expression in primary and metastatic osteosarcoma. (PubMed id 22542077)1 Gallagher R....Tawfik O. (2012)

    External Searches for MIB1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
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    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing MIB1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57534 HGNC: 21086 AceView: MIB1 Ensembl:ENSG00000101752 euGenes: HUgn57534
    ECgene: MIB1 H-InvDB: MIB1

    Other Databases showing MIB1 gene

    (According to HUGE)
    About This Section
    HUGE: KIAA1323

    Specialized Databases showing MIB1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MIB1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for MIB1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MIB1 gene:
    Search GeneIP for patents involving MIB1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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