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Aliases for MIAT Gene

Subcategory (RNA class) for MIAT Gene

non-coding RNA

Quality Score for this RNA gene is

3

Aliases for MIAT Gene

  • Myocardial Infarction Associated Transcript (Non-Protein Coding) 2 3 5
  • Long Intergenic Non-Protein Coding RNA 66 2 3
  • Chromosome 22 Open Reading Frame 35 2
  • Non-Protein Coding RNA 66 2
  • MI Related Novel MRNA 3
  • LncRNA-MIAT 3
  • NCRNA00066 3
  • LINC00066 3
  • C22orf35 3
  • GOMAFU 3
  • RNCR2 3

External Ids for MIAT Gene

Previous HGNC Symbols for MIAT Gene

  • C22orf35

Previous GeneCards Identifiers for MIAT Gene

  • GC22P025372
  • GC22P027042
  • GC22P010000

Summaries for MIAT Gene

Entrez Gene Summary for MIAT Gene

  • This gene encodes a spliced long non-coding RNA that may constitute a component of the nuclear matrix. Altered expression of this locus has been reported to be associated with a susceptibility to myocardial infarction. It has also been proposed that pathways involving this transcript may contribute to the pathophysiology of schizophrenia. A similar gene in mouse has been associated with retinal cell fate determination. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Dec 2014]

GeneCards Summary for MIAT Gene

MIAT (Myocardial Infarction Associated Transcript (Non-Protein Coding)) is an RNA Gene, and is affiliated with the non-coding RNA class. Diseases associated with MIAT include myocardial infarction and schizophrenia.

Gene Wiki entry for MIAT Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIAT Gene

Genomics for MIAT Gene

Regulatory Elements for MIAT Gene

Genomic Location for MIAT Gene

Chromosome:
22
Start:
26,646,428 bp from pter
End:
26,676,478 bp from pter
Size:
30,051 bases
Orientation:
Plus strand

Genomic View for MIAT Gene

Genes around MIAT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIAT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIAT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIAT Gene

Proteins for MIAT Gene

Post-translational modifications for MIAT Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIAT Gene

Domains & Families for MIAT Gene

Gene Families for MIAT Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIAT: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIAT Gene

Function for MIAT Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIAT Gene

Localization for MIAT Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MIAT Gene COMPARTMENTS Subcellular localization image for MIAT gene
Compartment Confidence
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for MIAT Gene

Pathways & Interactions for MIAT Gene

SuperPathways for MIAT Gene

No Data Available

Interacting Proteins for MIAT Gene

Gene Ontology (GO) - Biological Process for MIAT Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIAT Gene

Drugs & Compounds for MIAT Gene

No Compound Related Data Available

Transcripts for MIAT Gene

Unigene Clusters for MIAT Gene

Myocardial infarction associated transcript (non-protein coding):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MIAT Gene

No ASD Table

Relevant External Links for MIAT Gene

GeneLoc Exon Structure for
MIAT
ECgene alternative splicing isoforms for
MIAT

Expression for MIAT Gene

mRNA expression in normal human tissues for MIAT Gene

mRNA differential expression in normal tissues according to GTEx for MIAT Gene

This gene is overexpressed in Pituitary (x10.0), Brain - Frontal Cortex (BA9) (x6.6), Brain - Cortex (x6.0), Brain - Anterior cingulate cortex (BA24) (x4.4), and Whole Blood (x4.0).

SOURCE GeneReport for Unigene cluster for MIAT Gene Hs.517502

genes like me logo Genes that share expression patterns with MIAT: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MIAT Gene

Orthologs for MIAT Gene

Evolution for MIAT Gene

ENSEMBL:
Gene Tree for MIAT (if available)
TreeFam:
Gene Tree for MIAT (if available)

No data available for Orthologs for MIAT Gene

Paralogs for MIAT Gene

No data available for Paralogs for MIAT Gene

Variants for MIAT Gene

Sequence variations from dbSNP and Humsavar for MIAT Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs4274 -- 26,668,324(+) GGGAT(A/G)GAGCC nc-transcript-variant
rs7985 -- 26,670,572(+) TCTTA(A/G)AGTAA nc-transcript-variant
rs8209 -- 26,670,355(-) TATCC(C/T)ATCCA nc-transcript-variant
rs1061541 -- 26,665,973(+) AGTTT(C/T)AGCAC nc-transcript-variant
rs2301523 -- 26,666,705(+) GGGTG(A/G)AATAA nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for MIAT Gene

Variant ID Type Subtype PubMed ID
nsv7350 OTHER Inversion 18451855

Relevant External Links for MIAT Gene

HapMap Linkage Disequilibrium report
MIAT
Human Gene Mutation Database (HGMD)
MIAT

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIAT Gene

Disorders for MIAT Gene

MalaCards: The human disease database

(2) MalaCards diseases for MIAT Gene - From: OMIM and GeneCards

Disorder Aliases PubMed IDs
myocardial infarction
  • myocardial infarction, protection against
schizophrenia
  • schizophrenia 12
- elite association - COSMIC cancer census association via MalaCards
Search MIAT in MalaCards View complete list of genes associated with diseases

Relevant External Links for MIAT

Genetic Association Database (GAD)
MIAT
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIAT
genes like me logo Genes that share disorders with MIAT: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIAT Gene

Publications for MIAT Gene

  1. A long non-coding RNA signature in glioblastoma multiforme predicts survival. (PMID: 23726844) Zhang X.Q. … Leung G.K. (Neurobiol. Dis. 2013) 2 3 67
  2. The long non-coding RNA Gomafu is acutely regulated in response to neuronal activation and involved in schizophrenia-associated alternative splicing. (PMID: 23628989) Barry G. … Mattick J.S. (Mol. Psychiatry 2013) 2 3
  3. The mRNA-like noncoding RNA Gomafu constitutes a novel nuclear domain in a subset of neurons. (PMID: 17623775) Sone M. … Nakagawa S. (J. Cell. Sci. 2007) 2 3
  4. Identification of a novel non-coding RNA, MIAT, that confers risk of myocardial infarction. (PMID: 17066261) Ishii N. … Tanaka T. (J. Hum. Genet. 2006) 2 3
  5. lncRNA-MIAT regulates microvascular dysfunction by functioning as a competing endogenous RNA. (PMID: 25587098) Yan B. … Jiang Q. (Circ. Res. 2015) 3

Products for MIAT Gene

Sources for MIAT Gene

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