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Aliases for MIAT Gene

Subcategory (RNA class) for MIAT Gene

non-coding RNA

Quality Score for this RNA gene is


Aliases for MIAT Gene

  • Myocardial Infarction Associated Transcript (Non-Protein Coding) 2 3 5
  • Long Intergenic Non-Protein Coding RNA 66 2 3
  • Chromosome 22 Open Reading Frame 35 2
  • Non-Protein Coding RNA 66 2
  • MI Related Novel MRNA 3
  • LncRNA-MIAT 3
  • NCRNA00066 3
  • LINC00066 3
  • C22orf35 3
  • GOMAFU 3
  • RNCR2 3

External Ids for MIAT Gene

Previous HGNC Symbols for MIAT Gene

  • C22orf35

Previous GeneCards Identifiers for MIAT Gene

  • GC22P025372
  • GC22P027042
  • GC22P010000

Summaries for MIAT Gene

Entrez Gene Summary for MIAT Gene

  • This gene encodes a spliced long non-coding RNA that may constitute a component of the nuclear matrix. Altered expression of this locus has been reported to be associated with a susceptibility to myocardial infarction. It has also been proposed that pathways involving this transcript may contribute to the pathophysiology of schizophrenia. A similar gene in mouse has been associated with retinal cell fate determination. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Dec 2014]

GeneCards Summary for MIAT Gene

MIAT (Myocardial Infarction Associated Transcript (Non-Protein Coding)) is an RNA Gene, and is affiliated with the non-coding RNA class. Diseases associated with MIAT include Myocardial Infarction and Paranoid Schizophrenia.

Gene Wiki entry for MIAT Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIAT Gene

Genomics for MIAT Gene

Regulatory Elements for MIAT Gene

Enhancers for MIAT Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22F026668 0.9 Ensembl ENCODE 18 +26.2 26156 7.3 HDGF ATF1 PKNOX1 CREB3L1 WRNIP1 ZNF133 SIN3A ETS1 YY1 GLIS2 MIAT ENSG00000206028 TFIP11 HPS4 SRRD CRYBB1 CRYBA4 ENSG00000275942
GH22F026659 0.6 ENCODE 14.3 +11.6 11555 0.7 BCOR ZNF263 SMARCA5 SP3 SP2 ZMYM3 NFXL1 POLR2A ADNP ZNF341 MIAT CRYBB1 CRYBA4 HPS4 SRRD TFIP11 TPST2 ENSG00000206028 ENSG00000278404 ENSG00000277941
GH22F026660 0.8 Ensembl ENCODE 14 +14.7 14676 1.1 ZFP69B JUND SMARCA4 ZNF692 POLR2A HMBOX1 ZBTB40 MIAT CRYBB1 CRYBA4 HPS4 SRRD TFIP11 TPST2 ENSG00000206028 ENSG00000278404 ENSG00000277941
GH22F026664 0.9 Ensembl ENCODE 12.4 +19.3 19268 1.7 CTCF RAD21 RELA POLR2A ZNF366 ZNF143 SMC3 MAFK ZNF654 BHLHE40 MIAT TPST2 HMGB1P10 MIR548J TFIP11 CRYBB1 CRYBA4 HPS4 SRRD ENSG00000206028
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIAT on UCSC Golden Path with GeneCards custom track

Promoters for MIAT Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000616231 -1028 801 ATF1 PKNOX1 CREB3L1 ARID4B ZNF2 ETS1 YY1 GLIS2 ZNF143 SP3

Genomic Location for MIAT Gene

26,646,428 bp from pter
26,676,478 bp from pter
30,051 bases
Plus strand

Genomic View for MIAT Gene

Genes around MIAT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIAT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIAT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIAT Gene

Proteins for MIAT Gene

Post-translational modifications for MIAT Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIAT Gene

Domains & Families for MIAT Gene

Gene Families for MIAT Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIAT: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIAT Gene

Function for MIAT Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIAT Gene

Localization for MIAT Gene

Subcellular locations from

Jensen Localization Image for MIAT Gene COMPARTMENTS Subcellular localization image for MIAT gene
Compartment Confidence
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for MIAT Gene

Pathways & Interactions for MIAT Gene

SuperPathways for MIAT Gene

No Data Available

Interacting Proteins for MIAT Gene

Gene Ontology (GO) - Biological Process for MIAT Gene


No data available for Pathways by source and SIGNOR curated interactions for MIAT Gene

Transcripts for MIAT Gene

Unigene Clusters for MIAT Gene

Myocardial infarction associated transcript (non-protein coding):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MIAT Gene

No ASD Table

Relevant External Links for MIAT Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIAT Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIAT Gene

mRNA differential expression in normal tissues according to GTEx for MIAT Gene

This gene is overexpressed in Pituitary (x10.0), Brain - Frontal Cortex (BA9) (x6.6), Brain - Cortex (x6.0), Brain - Anterior cingulate cortex (BA24) (x4.4), and Whole Blood (x4.0).

NURSA nuclear receptor signaling pathways regulating expression of MIAT Gene:


SOURCE GeneReport for Unigene cluster for MIAT Gene:

genes like me logo Genes that share expression patterns with MIAT: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIAT Gene

Orthologs for MIAT Gene

Evolution for MIAT Gene

Gene Tree for MIAT (if available)
Gene Tree for MIAT (if available)

No data available for Orthologs for MIAT Gene

Paralogs for MIAT Gene

No data available for Paralogs for MIAT Gene

Variants for MIAT Gene

Sequence variations from dbSNP and Humsavar for MIAT Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs1007476 -- 26,660,685(+) TCTGC(G/T)TCTTC intron-variant
rs1018834 -- 26,673,944(+) AAAAA(A/T)ATATA intron-variant, nc-transcript-variant
rs1045362 -- 26,676,177(+) GACAT(A/G)TTGAG intron-variant, nc-transcript-variant
rs1045363 -- 26,676,183(+) TTGAG(C/T)TGGGG intron-variant, nc-transcript-variant
rs10529015 -- 26,665,247(+) GAAAA(-/AAAG/AAAGAAAG/AAAGAAAGAAAGAAAG)AAAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MIAT Gene

Variant ID Type Subtype PubMed ID
dgv1311e212 CNV loss 25503493
esv3568337 CNV loss 25503493
nsv7350 OTHER inversion 18451855

Relevant External Links for MIAT Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIAT Gene

Disorders for MIAT Gene

MalaCards: The human disease database

(4) MalaCards diseases for MIAT Gene - From: OMIM, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
myocardial infarction
  • myocardial infarction, protection against
paranoid schizophrenia
  • chronic paranoid schizophrenia
splenic disease
  • dyssplenism
  • schizophrenia 12
- elite association - COSMIC cancer census association via MalaCards
Search MIAT in MalaCards View complete list of genes associated with diseases

Relevant External Links for MIAT

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with MIAT: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIAT Gene

Publications for MIAT Gene

  1. The long non-coding RNA Gomafu is acutely regulated in response to neuronal activation and involved in schizophrenia-associated alternative splicing. (PMID: 23628989) Barry G. … Mattick J.S. (Mol. Psychiatry 2013) 2 3 64
  2. A long non-coding RNA signature in glioblastoma multiforme predicts survival. (PMID: 23726844) Zhang X.Q. … Leung G.K. (Neurobiol. Dis. 2013) 2 3 64
  3. The mRNA-like noncoding RNA Gomafu constitutes a novel nuclear domain in a subset of neurons. (PMID: 17623775) Sone M. … Nakagawa S. (J. Cell. Sci. 2007) 2 3 64
  4. Identification of a novel non-coding RNA, MIAT, that confers risk of myocardial infarction. (PMID: 17066261) Ishii N. … Tanaka T. (J. Hum. Genet. 2006) 2 3 64
  5. LncRNA MIAT: Myocardial infarction associated and more. (PMID: 26707210) Liao J. … Wang J. (Gene 2016) 3 64

Products for MIAT Gene

Sources for MIAT Gene

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