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Aliases for MIAT Gene

Subcategory (RNA class) for MIAT Gene

non-coding RNA

Quality Score for this RNA gene is


Aliases for MIAT Gene

  • Myocardial Infarction Associated Transcript (Non-Protein Coding) 2 3
  • Long Intergenic Non-Protein Coding RNA 66 2 3
  • Chromosome 22 Open Reading Frame 35 2
  • Non-Protein Coding RNA 66 2
  • MI Related Novel MRNA 3
  • LncRNA-MIAT 3
  • NCRNA00066 3
  • LINC00066 3
  • C22orf35 3
  • GOMAFU 3
  • RNCR2 3

External Ids for MIAT Gene

Previous HGNC Symbols for MIAT Gene

  • C22orf35

Previous GeneCards Identifiers for MIAT Gene

  • GC22P025372
  • GC22P027042
  • GC22P010000

Summaries for MIAT Gene

Entrez Gene Summary for MIAT Gene

  • This gene encodes a spliced long non-coding RNA that may constitute a component of the nuclear matrix. Altered expression of this locus has been reported to be associated with a susceptibility to myocardial infarction. It has also been proposed that pathways involving this transcript may contribute to the pathophysiology of schizophrenia. A similar gene in mouse has been associated with retinal cell fate determination. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Dec 2014]

GeneCards Summary for MIAT Gene

MIAT (Myocardial Infarction Associated Transcript (Non-Protein Coding)) is an RNA Gene, and is affiliated with the non-coding RNA class. Diseases associated with MIAT include myocardial infarction and splenic disease.

Gene Wiki entry for MIAT Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIAT Gene

Genomics for MIAT Gene

Regulatory Elements for MIAT Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MIAT Gene

26,646,428 bp from pter
26,676,478 bp from pter
30,051 bases
Plus strand

Genomic View for MIAT Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIAT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIAT Gene

Proteins for MIAT Gene

Post-translational modifications for MIAT Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIAT Gene

Domains & Families for MIAT Gene

Gene Families for MIAT Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIAT: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIAT Gene

Function for MIAT Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIAT Gene

Localization for MIAT Gene

Subcellular locations from

Jensen Localization Image for MIAT Gene COMPARTMENTS Subcellular localization image for MIAT gene
Compartment Confidence
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for MIAT Gene

Pathways & Interactions for MIAT Gene

SuperPathways for MIAT Gene

No Data Available

Interacting Proteins for MIAT Gene

Gene Ontology (GO) - Biological Process for MIAT Gene


No data available for Pathways by source and SIGNOR curated interactions for MIAT Gene

Drugs & Compounds for MIAT Gene

No Compound Related Data Available

Transcripts for MIAT Gene

Unigene Clusters for MIAT Gene

Myocardial infarction associated transcript (non-protein coding):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MIAT Gene

No ASD Table

Relevant External Links for MIAT Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIAT Gene

mRNA expression in normal human tissues for MIAT Gene

mRNA differential expression in normal tissues according to GTEx for MIAT Gene

This gene is overexpressed in Pituitary (x10.0), Brain - Frontal Cortex (BA9) (x6.6), Brain - Cortex (x6.0), Brain - Anterior cingulate cortex (BA24) (x4.4), and Whole Blood (x4.0).

SOURCE GeneReport for Unigene cluster for MIAT Gene Hs.517502

genes like me logo Genes that share expression patterns with MIAT: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MIAT Gene

Orthologs for MIAT Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for MIAT Gene

Organism Taxonomy Gene Similarity Type Details
(Mus musculus)
Mammalia Miat 16
Species with no ortholog for MIAT:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIAT Gene

Gene Tree for MIAT (if available)
Gene Tree for MIAT (if available)

Paralogs for MIAT Gene

No data available for Paralogs for MIAT Gene

Variants for MIAT Gene

Sequence variations from dbSNP and Humsavar for MIAT Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs4274 -- 26,668,324(+) GGGAT(A/G)GAGCC nc-transcript-variant
rs7985 -- 26,670,572(+) TCTTA(A/G)AGTAA nc-transcript-variant
rs8209 -- 26,670,355(-) TATCC(C/T)ATCCA nc-transcript-variant
rs8775 -- 26,670,494(-) AGCTT(A/G)CTAGG nc-transcript-variant
rs1007476 -- 26,660,685(+) TCTGC(A/G/T)TCTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MIAT Gene

Variant ID Type Subtype PubMed ID
nsv7350 OTHER Inversion 18451855

Relevant External Links for MIAT Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIAT Gene

Disorders for MIAT Gene

MalaCards: The human disease database

(3) MalaCards diseases for MIAT Gene - From: OMIM, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
myocardial infarction
  • myocardial infarction, protection against
splenic disease
  • dyssplenism
  • schizophrenia 12
- elite association
Search MIAT in MalaCards View complete list of genes associated with diseases

Relevant External Links for MIAT

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with MIAT: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIAT Gene

Publications for MIAT Gene

  1. The long non-coding RNA Gomafu is acutely regulated in response to neuronal activation and involved in schizophrenia-associated alternative splicing. (PMID: 23628989) Barry G. … Mattick J.S. (Mol. Psychiatry 2013) 2 67
  2. A long non-coding RNA signature in glioblastoma multiforme predicts survival. (PMID: 23726844) Zhang X.Q. … Leung G.K. (Neurobiol. Dis. 2013) 2 67
  3. The mRNA-like noncoding RNA Gomafu constitutes a novel nuclear domain in a subset of neurons. (PMID: 17623775) Sone M. … Nakagawa S. (J. Cell. Sci. 2007) 2 67
  4. Identification of a novel non-coding RNA, MIAT, that confers risk of myocardial infarction. (PMID: 17066261) Ishii N. … Tanaka T. (J. Hum. Genet. 2006) 2 67
  5. lncRNA-MIAT regulates microvascular dysfunction by functioning as a competing endogenous RNA. (PMID: 25587098) Yan B. … Jiang Q. (Circ. Res. 2015) 67

Products for MIAT Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate MIAT
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for MIAT
    • Block miRNA regulation of MIAT using miScript Target Protectors

    Sources for MIAT Gene

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