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Aliases for MIA2 Gene

Aliases for MIA2 Gene

  • Melanoma Inhibitory Activity 2 2 3 5

External Ids for MIA2 Gene

Previous GeneCards Identifiers for MIA2 Gene

  • GC14P037083
  • GC14M033560
  • GC14P037693
  • GC14P038772
  • GC14P039703
  • GC14P019817

Summaries for MIA2 Gene

GeneCards Summary for MIA2 Gene

MIA2 (Melanoma Inhibitory Activity 2) is a Protein Coding gene. An important paralog of this gene is CTAGE9.

UniProtKB/Swiss-Prot for MIA2 Gene

  • May play a role in the pathophysiology of liver disease and may serve as a marker of liver damage.

Gene Wiki entry for MIA2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIA2 Gene

Genomics for MIA2 Gene

Regulatory Elements for MIA2 Gene

Enhancers for MIA2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MIA2 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIA2 Gene

39,230,231 bp from pter
39,253,655 bp from pter
23,425 bases
Plus strand

Genomic View for MIA2 Gene

Genes around MIA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIA2 Gene

Proteins for MIA2 Gene

  • Protein details for MIA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Melanoma inhibitory activity protein 2
    Protein Accession:
    Secondary Accessions:
    • A1L4H0
    • Q9H6C1

    Protein attributes for MIA2 Gene

    542 amino acids
    Molecular mass:
    61771 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MIA2 Gene


neXtProt entry for MIA2 Gene

Proteomics data for MIA2 Gene at MOPED

Post-translational modifications for MIA2 Gene

  • Glycosylation at Asn 59 and Asn 368
  • Modification sites at PhosphoSitePlus

Other Protein References for MIA2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MIA2 Gene

Domains & Families for MIA2 Gene

Protein Domains for MIA2 Gene


Suggested Antigen Peptide Sequences for MIA2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 SH3 domain.
  • Belongs to the MIA/OTOR family.
  • Contains 1 SH3 domain.
  • Belongs to the MIA/OTOR family.
genes like me logo Genes that share domains with MIA2: view

No data available for Gene Families for MIA2 Gene

Function for MIA2 Gene

Molecular function for MIA2 Gene

UniProtKB/Swiss-Prot Function:
May play a role in the pathophysiology of liver disease and may serve as a marker of liver damage.
genes like me logo Genes that share phenotypes with MIA2: view

Animal Model Products

miRNA for MIA2 Gene

miRTarBase miRNAs that target MIA2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MIA2 Gene

Localization for MIA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIA2 Gene


Subcellular locations from

Jensen Localization Image for MIA2 Gene COMPARTMENTS Subcellular localization image for MIA2 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 4
mitochondrion 2

Gene Ontology (GO) - Cellular Components for MIA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with MIA2: view

Pathways & Interactions for MIA2 Gene

SuperPathways for MIA2 Gene

No Data Available

Interacting Proteins for MIA2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000280082 for MIA2 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for MIA2 Gene


No data available for Pathways by source and SIGNOR curated interactions for MIA2 Gene

Drugs & Compounds for MIA2 Gene

No Compound Related Data Available

Transcripts for MIA2 Gene

mRNA/cDNA for MIA2 Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MIA2 Gene

Melanoma inhibitory activity 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MIA2 Gene

No ASD Table

Relevant External Links for MIA2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIA2 Gene

mRNA expression in normal human tissues for MIA2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MIA2 Gene

This gene is overexpressed in Liver (x21.0), Kidney - Cortex (x8.5), Pancreas (x6.8), and Small Intestine - Terminal Ileum (x6.7).

Protein differential expression in normal tissues from HIPED for MIA2 Gene

This gene is overexpressed in Lymph node (27.7), Uterus (8.9), Esophagus (7.6), and Rectum (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MIA2 Gene

SOURCE GeneReport for Unigene cluster for MIA2 Gene Hs.287694

mRNA Expression by UniProt/SwissProt for MIA2 Gene

Tissue specificity: Highly expressed in liver and weakly in testis. Expression was higher in patients with severe fibrosis or inflammation and chronic hepatitis.
genes like me logo Genes that share expression patterns with MIA2: view

Primer Products

No data available for Protein tissue co-expression partners for MIA2 Gene

Orthologs for MIA2 Gene

This gene was present in the common ancestor of animals.

Orthologs for MIA2 Gene

Organism Taxonomy Gene Similarity Type Details
(Mus musculus)
Mammalia Mia2 35
  • 75.7 (n)
  • 59.92 (a)
Mia2 16
Mia2 36
  • 58 (a)
(Pan troglodytes)
Mammalia MIA2 35
  • 99.75 (n)
  • 99.54 (a)
MIA2 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Ctage5 35
  • 75.13 (n)
  • 58.59 (a)
(Bos Taurus)
Mammalia MIA2 36
  • 71 (a)
(Canis familiaris)
Mammalia -- 36
  • 10 (a)
fruit fly
(Drosophila melanogaster)
Insecta Tango1 36
  • 5 (a)
Species with no ortholog for MIA2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIA2 Gene

Gene Tree for MIA2 (if available)
Gene Tree for MIA2 (if available)

Paralogs for MIA2 Gene

(3) SIMAP similar genes for MIA2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with MIA2: view

Variants for MIA2 Gene

Sequence variations from dbSNP and Humsavar for MIA2 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
VAR_036460 A breast cancer sample
rs7140766 -- 39,237,537(+) CAGTG(G/T)TGGTT intron-variant
rs7141840 -- 39,234,120(+) ATGGC(A/G)AAATT reference, synonymous-codon
rs441084 -- 39,251,493(+) ttttt(A/C)ttata intron-variant
rs1570131 -- 39,251,806(+) ACTCA(C/T)AAGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MIA2 Gene

Variant ID Type Subtype PubMed ID
nsv84871 CNV Loss 16902084
esv272287 CNV Insertion 20981092

Variation tolerance for MIA2 Gene

Residual Variation Intolerance Score: 84.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.60; 78.11% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for MIA2 Gene

Disorders for MIA2 Gene

Relevant External Links for MIA2

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MIA2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIA2 Gene

Publications for MIA2 Gene

  1. Specific expression and regulation of the new melanoma inhibitory activity-related gene MIA2 in hepatocytes. (PMID: 12586826) Bosserhoff A.K. … Hellerbrand C. (J. Biol. Chem. 2003) 2 3 4 67
  2. A common genetic variation of melanoma inhibitory activity-2 labels a subtype of pancreatic adenocarcinoma with high endoplasmic reticulum stress levels. (PMID: 25657029) Kong B. … Michalski C.W. (Sci Rep 2015) 3
  3. Protumoral roles of melanoma inhibitory activity 2 in oral squamous cell carcinoma. (PMID: 23511560) Kurihara M. … Kuniyasu H. (Br. J. Cancer 2013) 3
  4. Comprehensive analysis of interactions between the Src-associated protein in mitosis of 68 kDa and the human Src-homology 3 proteome. (PMID: 22745667) Asbach B. … Wagner R. (PLoS ONE 2012) 3
  5. A synthetic interaction screen identifies factors selectively required for proliferation and TERT transcription in p53-deficient human cancer cells. (PMID: 23284306) Xie L. … Green M.R. (PLoS Genet. 2012) 3

Products for MIA2 Gene

Sources for MIA2 Gene