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Aliases for MIA Gene

Aliases for MIA Gene

  • Melanoma Inhibitory Activity 2 3 5
  • Melanoma Inhibitory Activity Protein 4
  • CD-RAP 3

External Ids for MIA Gene

Previous GeneCards Identifiers for MIA Gene

  • GC19P041920
  • GC19P041673
  • GC19P045958
  • GC19P045975
  • GC19P045976
  • GC19P045978
  • GC19P041283
  • GC19P037714

Summaries for MIA Gene

GeneCards Summary for MIA Gene

MIA (Melanoma Inhibitory Activity) is a Protein Coding gene. Diseases associated with MIA include melanoma and skin melanoma. Among its related pathways are Neural Crest Differentiation. GO annotations related to this gene include growth factor activity. An important paralog of this gene is MIA-RAB4B.

UniProtKB/Swiss-Prot for MIA Gene

  • Elicits growth inhibition on melanoma cells in vitro as well as some other neuroectodermal tumors, including gliomas.

Gene Wiki entry for MIA Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIA Gene

Genomics for MIA Gene

Regulatory Elements for MIA Gene

Genomic Location for MIA Gene

40,771,648 bp from pter
40,777,493 bp from pter
5,846 bases
Plus strand

Genomic View for MIA Gene

Genes around MIA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIA Gene

Proteins for MIA Gene

  • Protein details for MIA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Melanoma-derived growth regulatory protein
    Protein Accession:
    Secondary Accessions:
    • Q6FHV3

    Protein attributes for MIA Gene

    131 amino acids
    Molecular mass:
    14509 Da
    Quaternary structure:
    • Interacts with FASLG. Interacts with TMIGD2.

    Three dimensional structures from OCA and Proteopedia for MIA Gene

    Alternative splice isoforms for MIA Gene


neXtProt entry for MIA Gene

Proteomics data for MIA Gene at MOPED

Post-translational modifications for MIA Gene

Other Protein References for MIA Gene

Antibody Products

No data available for DME Specific Peptides for MIA Gene

Domains & Families for MIA Gene

Protein Domains for MIA Gene


Suggested Antigen Peptide Sequences for MIA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 SH3 domain.
  • Belongs to the MIA/OTOR family.
  • Contains 1 SH3 domain.
  • Belongs to the MIA/OTOR family.
genes like me logo Genes that share domains with MIA: view

No data available for Gene Families for MIA Gene

Function for MIA Gene

Molecular function for MIA Gene

GENATLAS Biochemistry:
melanoma inhibitory activity,11kDa,regulator of cell growth (see TSG19A)
UniProtKB/Swiss-Prot Function:
Elicits growth inhibition on melanoma cells in vitro as well as some other neuroectodermal tumors, including gliomas.
genes like me logo Genes that share phenotypes with MIA: view

Animal Models for MIA Gene

MGI Knock Outs for MIA:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for MIA Gene

Localization for MIA Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIA Gene


Subcellular locations from

Jensen Localization Image for MIA Gene COMPARTMENTS Subcellular localization image for MIA gene
Compartment Confidence
extracellular 5
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for MIA Gene

Pathways & Interactions for MIA Gene

SuperPathways for MIA Gene

genes like me logo Genes that share pathways with MIA: view

Pathways by source for MIA Gene

1 BioSystems pathway for MIA Gene

Interacting Proteins for MIA Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: Q16674-MIA_HUMAN ENSP00000263369 for MIA Gene via I2D STRING

Gene Ontology (GO) - Biological Process for MIA Gene


No data available for SIGNOR curated interactions for MIA Gene

Drugs & Compounds for MIA Gene

No Compound Related Data Available

Transcripts for MIA Gene

Unigene Clusters for MIA Gene

Melanoma inhibitory activity:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MIA Gene

No ASD Table

Relevant External Links for MIA Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIA Gene

mRNA expression in normal human tissues for MIA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MIA Gene

This gene is overexpressed in Nerve - Tibial (x19.5) and Pituitary (x9.7).

Protein differential expression in normal tissues from HIPED for MIA Gene

This gene is overexpressed in Lung (52.1) and Testis (16.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MIA Gene

SOURCE GeneReport for Unigene cluster for MIA Gene Hs.646364

mRNA Expression by UniProt/SwissProt for MIA Gene

Tissue specificity: All malignant melanoma cell lines tested and infrequently in glioma cell lines.
genes like me logo Genes that share expression patterns with MIA: view

Protein tissue co-expression partners for MIA Gene

Primer Products

In Situ Assay Products

Orthologs for MIA Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIA Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MIA 35
  • 87.69 (n)
  • 86.15 (a)
MIA 36
  • 86 (a)
(Canis familiaris)
Mammalia MIA 35
  • 89.06 (n)
  • 87.79 (a)
(Mus musculus)
Mammalia Mia 35
  • 84.62 (n)
  • 82.31 (a)
Mia 16
Gm21983 36
  • 77 (a)
Mia 36
  • 82 (a)
(Pan troglodytes)
Mammalia MIA 35
  • 99.49 (n)
  • 100 (a)
-- 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Mia 35
  • 83.59 (n)
  • 83.85 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mia 35
  • 68.58 (n)
  • 68.85 (a)
(Danio rerio)
Actinopterygii zgc:194158 35
  • 61.28 (n)
  • 56.92 (a)
MIA 36
  • 55 (a)
Species with no ortholog for MIA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIA Gene

Gene Tree for MIA (if available)
Gene Tree for MIA (if available)

Paralogs for MIA Gene

Paralogs for MIA Gene

(4) SIMAP similar genes for MIA Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with MIA: view

Variants for MIA Gene

Sequence variations from dbSNP and Humsavar for MIA Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs2607419 -- 40,773,490(-) ATAAG(C/T)GTGAG upstream-variant-2KB
rs35547763 -- 40,773,434(+) GTCTC(-/A)AAAAA upstream-variant-2KB
rs60460080 -- 40,773,359(+) ACCCG(A/G)GAGGG upstream-variant-2KB
rs71173677 -- 40,773,454(+) AAAAA(-/A)GAAAT upstream-variant-2KB
rs111408303 -- 40,773,520(+) GCTGC(A/G)GTGGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIA Gene

Variant ID Type Subtype PubMed ID
nsv833832 CNV Loss 17160897
esv26234 CNV Loss 19812545

Variation tolerance for MIA Gene

Residual Variation Intolerance Score: 56.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.88; 18.33% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MIA Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MIA Gene

Disorders for MIA Gene

MalaCards: The human disease database

(3) MalaCards diseases for MIA Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
  • malignant melanoma
skin melanoma
  • melanoma
uveal melanoma
  • melanoma of uvea
- elite association - COSMIC cancer census association via MalaCards
Search MIA in MalaCards View complete list of genes associated with diseases

Relevant External Links for MIA

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with MIA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIA Gene

Publications for MIA Gene

  1. Cloning of a novel malignant melanoma-derived growth-regulatory protein, MIA. (PMID: 7923218) Blesch A. … Bogdahn U. (Cancer Res. 1994) 2 3 4 67
  2. Melanoma-inhibiting activity (MIA/CD-RAP) is expressed in a variety of malignant tumors of mainly neuroectodermal origin. (PMID: 12014625) Hau P. … Bogdahn U. (Anticancer Res. 2002) 3 23
  3. Structure and promoter analysis of the gene encoding the human melanoma-inhibiting protein MIA. (PMID: 8550608) Bosserhoff A.-K. … Buettner R. (J. Biol. Chem. 1996) 3 23
  4. Assignment of the human melanoma inhibitory activity gene (MIA) to 19q13.32-q13.33 by fluorescence in situ hybridization (FISH). (PMID: 8661134) Koehler M.R. … Schmid M. (Genomics 1996) 2 3
  5. Melanoma inhibitory activity in melanoma diagnostics and therapy - a small protein is looming large. (PMID: 24372647) Riechers A. … Bosserhoff A.K. (Exp. Dermatol. 2014) 3

Products for MIA Gene

Sources for MIA Gene

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