MIA Gene
protein-coding GIFtS : 56
GCID: GC19 P041283
melanoma inhibitory activity
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Aliasesfor MIA gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Melanoma Inhibitory Activity 1 2 CD-RAP1 2 Melanoma-Derived Growth Regulatory Protein2 Melanoma Inhibitory Activity Protein3
Export aliases for MIA gene to outside databases Previous GC identifers: GC19P041920 GC19P041673 GC19P045958 GC19P045975 GC19P045976 GC19P045978 GC19P037714
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Summariesfor MIA gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: MIA_HUMAN, Q16674 Function : Elicits growth inhibition on melanoma cells in vitro as well as some other neuroectodermal tumors, includinggliomas Gene Wiki entry for MIA (Melanoma inhibitory activity)
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Genomic Viewsfor MIA gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000019.9 NC_018930.1 NT_011109.16 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the MIA gene promoter: E2F-4 E2F-3a C/EBPbeta AP-1 ATF-2 E2F-2 E2F E2F-1 c-Jun Other transcription factors Search SABiosciences Chromatin IP Primers for MIA Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MIA
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 19q13.2 Ensembl cytogenetic band: 19q13.2 HGNC cytogenetic band: 19q13.2 MIA Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 19 GeneLoc Exon Structure
GeneLoc location for GC19P041283: view genomic region
(about GC identifiers )
Start:
41,281,300 bp from pter
End:
41,283,395 bp from pter
Size:
2,096 bases
Orientation:
plus strand
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Proteinsfor MIA gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: MIA_HUMAN, Q16674 (See
protein sequence )Recommended Name: Melanoma-derived growth regulatory protein precursor Size : 131 amino acids; 14509 Da
Subunit : Interacts with FASLG. Interacts with TMIGD2
Subcellular location : Secreted
3 PDB 3D structures from and Proteopedia for MIA :1HJD (3D)
  1I1J (3D)
  1K0X (3D)
 
Secondary accessions : Q6FHV3Alternative splicing : 2 isoforms : Q16674-1 Q16674-2 Explore the universe of human proteins at neXtProt for MIA: NX_Q16674 Post-translational modifications:
May possess two intramolecular disulfide bonds1
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q16674 MIA Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins (2 alternative transcripts):
NP_001189482.1 NP_006524.1 ENSEMBL proteins: ENSP00000263369 Human Recombinant Protein Products: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
MIA for ontologies About GeneDecksing MIA Antibody Products: Assay Products for MIA:
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Protein
Domains / Familiesfor MIA gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
MIA for domains About GeneDecksing 2 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q16674 ProtoNet protein and cluster: Q16674
1 Blocks protein family : IPB001452 SH3 domain signature UniProtKB/Swiss-Prot: MIA_HUMAN, Q16674 Similarity : Belongs to the MIA/OTOR familySimilarity : Contains 1 SH3 domain
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Functionfor MIA gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: MIA_HUMAN, Q16674 Function : Elicits growth inhibition on melanoma cells in vitro as well as some other neuroectodermal tumors, includinggliomas
Genatlas biochemistry entry for MIA : melanoma inhibitory activity,11kDa,regulator of cell growth (see TSG19A) Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for MIA (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for MIAOriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): MIA (NM_006533 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MIA Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat MIA
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MIA
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0008083 growth factor activity
IEA --
MIA for ontologies About GeneDecksing 1 GenomeRNAi human phenotype for MIA :Animal Models: Mouse knock-out Mia tm1Rbu for MIA 3 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Mia) :
MIA for phenotypes About GeneDecksing
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Pathways & Interactionsfor MIA gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways   About this table See pathways by source Super-pathway contained gene-specific pathways 1 Neural Crest Differentiation
1 BioSystems Pathway for MIA Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MIA STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)2 Interacting proteins for MIA (Q16674 3 ENSP00000263369 4 ) via UniProtKB, MINT, STRING , and/or I2D About this table Gene Ontology (GO): 3 biological process terms (GO ID links to tree view) : About this table
MIA for ontologies About GeneDecksing
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Drugs & Compoundsfor MIA gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for MIA Search CenterWatch for drugs/clinical trials and news about MIA
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Transcriptsfor MIA gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for MIA gene (2 alternative transcripts): NM_001202553.1 NM_006533.3 Unigene Cluster for MIA:
Melanoma inhibitory activity Hs.646364 [show with all ESTs ] Unigene Representative Sequence: BG765502 1 Ensembl transcript including schematic representation, and UCSC links where relevant : ENST00000263369 (uc010xvt.1 uc021uuu.1 uc002opb.4 ) Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for MIA (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for MIAOriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): MIA (NM_006533 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MIA Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat MIA
Additional cDNA sequence: BC005910.1 BT007044.1 CR541648.1 X75450.1
6 DOTS entries : DT.215114 DT.100792664
DT.121503341 DT.121503423 DT.121503385 DT.91750613 24/186 AceView cDNA sequences (see all 186 ):
AI797993 BQ935941 BM561937 BQ957483 X75450 AI086169 AW793349 BX480149 CA435622 BC046927 BM856478 CR541648 AI493506 BU956946 AK024845 AI934691 BQ279120 BX280685 BQ927637 AI830148 BU150091 CD673201 BQ279167 AA815081 GeneLoc Exon Structure
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Expression for MIA gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section MIA expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: GCCCCCGACT
About this image MIA expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table See MIA Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for MIA SOURCE GeneReport for Unigene cluster: Hs.646364 UniProtKB/Swiss-Prot: MIA_HUMAN, Q16674 Tissue specificity : All malignant melanoma cell lines tested and infrequently in glioma cell lines SABiosciences Custom PCR Arrays for MIA Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for MIABrowse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat MIA QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat MIA QIAGEN QuantiFast Probe-based Assays in human , mouse , rat MIA In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MIA
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Orthologsfor MIA gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of animals.
Orthologs for MIA gene from 4/11 species (see all 11 ) About this table
ENSEMBL Gene Tree for MIA (if available)TreeFam Gene Tree for MIA (if available)
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Paralogsfor MIA gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for MIA gene MIA2 2 OTOR 2 4 SIMAP similar genes for MIA using alignment to 4 protein entries: MIA_HUMAN (see all proteins ):OTOR MIA3 CTAGE5 MIA2
MIA for paralogs About GeneDecksing
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Genomic Variantsfor MIA gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 19 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for MIA (41281300 - 41283395 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 2 variations for MIA 2 CNVs : 73368 5100
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing MIA
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Disorders
/ Diseasesfor MIA gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
MIA for disorders About GeneDecksing
OMIM gene information: 601340
OMIM disorders : --11 diseases for MIA : About MalaCards melanoma oral squamous cell carcinoma squamous cell carcinoma periostitis neuroectodermal tumors skin melanoma noma gastric cancer pancreatic cancer pancreatitis carcinoma 1 disease from the University of Copenhagen DISEASES database for MIA :Melanoma Export disorders for MIA gene to outside databases
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Publicationsfor MIA gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for MIA gene, integrated from 9 sources (see all 41 ): (articles sorted by number of sources associating them with MIA) Utopia : connect your pdf to the dynamic world of online information
Cloning of a novel malignant melanoma-derived growth-regulatory protein, MIA. (PubMed id 7923218) 1 , 2 , 3 Blesch A.... Bogdahn U. (1994) Structure and promoter analysis of the gene encoding the human melanoma-inhibiting protein MIA. (PubMed id 8550608) 1 , 2 , 9 Bosserhoff A.-K.... Buettner R. (1996) Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening. (PubMed id 19807924) 1 , 2 Voss M....Janssen O. (2009) Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161) 1 , 2 Zhang Z. and Henzel W.J. (2004) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Cloning and characterization of the expression pattern of a novel splice product MIA (splice) of malignant melanoma-derived growth-inhibiting activity (MIA/CD-RAP) [corrected]. (PubMed id 12230496) 1 , 2 Hau P....Apfel R. (2002) Structure of melanoma inhibitory activity protein, a member of a recently identified family of secreted proteins. (PubMed id 11331761) 1 , 2 Lougheed J.C.... Handel T.M. (2001) Assignment of the human melanoma inhibitory activity gene (MIA) to 19q13.32-q13.33 by fluorescence in situ hybridization (FISH). (PubMed id 8661134) 1 , 3 Koehler M.R....Schmid M. (1996) Melanoma-inhibiting activity (MIA/CD-RAP) is expressed in a variety of malignant tumors of mainly neuroectodermal origin. (PubMed id 12014625) 1 , 9 Hau P....Bogdahn U. (2002) A genome-wide association study identifies three new r isk loci for Kawasaki disease. (PubMed id 22446962) 1 Onouchi Y.... . (2012)
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External Searches for MIA gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing MIA gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing MIA gene
(According to HUGE )
About This Section --
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Specialized Databases showing MIA gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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About This Section Patent Information for MIA gene: Search GeneIP for patents involving MIA GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor MIA gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for MIA OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for MIA OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for MIA OriGene Protein Over-expression Lysate for MIA Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for MIA OriGene 3'-UTR Clone for MIA OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for MIA OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for MIA Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for MIA OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for MIA OriGene Custom Protein Services for MIA OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MIA QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing MIA QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MIA QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat MIA QIAGEN QuantiFast Probe-based Assays in human , mouse , rat MIA QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat MIA
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