Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MIA Gene

Aliases for MIA Gene

  • Melanoma Inhibitory Activity 2 3 5
  • Melanoma-Derived Growth Regulatory Protein 3
  • Melanoma Inhibitory Activity Protein 4
  • CD-RAP 3

External Ids for MIA Gene

Previous GeneCards Identifiers for MIA Gene

  • GC19P041920
  • GC19P041673
  • GC19P045958
  • GC19P045975
  • GC19P045976
  • GC19P045978
  • GC19P041283
  • GC19P037714

Summaries for MIA Gene

GeneCards Summary for MIA Gene

MIA (Melanoma Inhibitory Activity) is a Protein Coding gene. Diseases associated with MIA include Skin Melanoma and Uveal Melanoma. Among its related pathways are Neural Crest Differentiation. GO annotations related to this gene include growth factor activity. An important paralog of this gene is MIA-RAB4B.

UniProtKB/Swiss-Prot for MIA Gene

  • Elicits growth inhibition on melanoma cells in vitro as well as some other neuroectodermal tumors, including gliomas.

Gene Wiki entry for MIA Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIA Gene

Genomics for MIA Gene

Regulatory Elements for MIA Gene

Enhancers for MIA Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F040747 1.6 FANTOM5 ENCODE 9.4 -18.9 -18887 9.8 MLX CREB3L1 ZFP64 YBX1 FEZF1 DMAP1 YY1 ZNF416 ZNF143 ZNF263 SNRPA FBL ENSG00000269843 COQ8B ITPKC CCDC97 SERTAD3 ENSG00000269069 CYP2G2P ENSG00000271299
GH19F040776 1.1 ENCODE 12 +6.3 6296 3.3 HDGF PKNOX1 WRNIP1 ZFP64 ARID4B SIN3A ZNF2 YY1 ZNF207 ZNF143 SNRPA FBL ENSG00000269843 PSMC4 ITPKC CCDC97 CYP2F2P C19orf54 MIA RNU6-195P
GH19F040713 1.9 FANTOM5 Ensembl ENCODE 6.4 -53.3 -53301 9.2 CREB3L1 FEZF1 DMAP1 YY1 ZNF143 ZNF416 ZNF548 SP3 NFYC SSRP1 SNRPA ITPKC ENSG00000269843 FBL CCDC97 ENSG00000268366 SERTAD3 PSMC4 COQ8B CYP2G2P
GH19F040774 0.8 Ensembl ENCODE 12.4 +3.7 3672 1.4 ZNF664 ZFHX2 IKZF1 ZMYM3 C19orf54 MIA SNRPA RNU6-195P ITPKC RAB4B MIA-RAB4B
GH19F040761 0.6 ENCODE 10.5 -9.7 -9670 0.8 ZBTB48 POLR2A ZNF747 ZNF600 PRDM10 NR2F2 ENSG00000269843 SNRPA MIA PSMC4 GC19P040765 C19orf54
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIA on UCSC Golden Path with GeneCards custom track

Genomic Location for MIA Gene

Chromosome:
19
Start:
40,771,648 bp from pter
End:
40,777,493 bp from pter
Size:
5,846 bases
Orientation:
Plus strand

Genomic View for MIA Gene

Genes around MIA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIA Gene

Proteins for MIA Gene

  • Protein details for MIA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16674-MIA_HUMAN
    Recommended name:
    Melanoma-derived growth regulatory protein
    Protein Accession:
    Q16674
    Secondary Accessions:
    • Q6FHV3

    Protein attributes for MIA Gene

    Size:
    131 amino acids
    Molecular mass:
    14509 Da
    Quaternary structure:
    • Interacts with FASLG. Interacts with TMIGD2.

    Three dimensional structures from OCA and Proteopedia for MIA Gene

    Alternative splice isoforms for MIA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MIA Gene

Post-translational modifications for MIA Gene

Other Protein References for MIA Gene

No data available for DME Specific Peptides for MIA Gene

Domains & Families for MIA Gene

Gene Families for MIA Gene

Protein Domains for MIA Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for MIA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q16674

UniProtKB/Swiss-Prot:

MIA_HUMAN :
  • Contains 1 SH3 domain.
  • Belongs to the MIA/OTOR family.
Domain:
  • Contains 1 SH3 domain.
Family:
  • Belongs to the MIA/OTOR family.
genes like me logo Genes that share domains with MIA: view

Function for MIA Gene

Molecular function for MIA Gene

GENATLAS Biochemistry:
melanoma inhibitory activity,11kDa,regulator of cell growth (see TSG19A)
UniProtKB/Swiss-Prot Function:
Elicits growth inhibition on melanoma cells in vitro as well as some other neuroectodermal tumors, including gliomas.

Gene Ontology (GO) - Molecular Function for MIA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008083 growth factor activity IEA --
genes like me logo Genes that share ontologies with MIA: view
genes like me logo Genes that share phenotypes with MIA: view

Animal Models for MIA Gene

MGI Knock Outs for MIA:

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for MIA Gene

Localization for MIA Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIA Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIA gene
Compartment Confidence
extracellular 5
plasma membrane 1

Gene Ontology (GO) - Cellular Components for MIA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space TAS 7923218
genes like me logo Genes that share ontologies with MIA: view

Pathways & Interactions for MIA Gene

SuperPathway Contained pathways
1 Neural Crest Differentiation
genes like me logo Genes that share pathways with MIA: view

Pathways by source for MIA Gene

1 BioSystems pathway for MIA Gene

Interacting Proteins for MIA Gene

Gene Ontology (GO) - Biological Process for MIA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008283 cell proliferation TAS 7923218
genes like me logo Genes that share ontologies with MIA: view

No data available for SIGNOR curated interactions for MIA Gene

Transcripts for MIA Gene

Unigene Clusters for MIA Gene

Melanoma inhibitory activity:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIA Gene

No ASD Table

Relevant External Links for MIA Gene

GeneLoc Exon Structure for
MIA
ECgene alternative splicing isoforms for
MIA

Expression for MIA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MIA Gene

This gene is overexpressed in Nerve - Tibial (x19.5) and Pituitary (x9.7).

Protein differential expression in normal tissues from HIPED for MIA Gene

This gene is overexpressed in Lung (52.1) and Testis (16.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MIA Gene



Protein tissue co-expression partners for MIA Gene

NURSA nuclear receptor signaling pathways regulating expression of MIA Gene:

MIA

SOURCE GeneReport for Unigene cluster for MIA Gene:

Hs.646364

mRNA Expression by UniProt/SwissProt for MIA Gene:

Q16674-MIA_HUMAN
Tissue specificity: All malignant melanoma cell lines tested and infrequently in glioma cell lines.
genes like me logo Genes that share expression patterns with MIA: view

Orthologs for MIA Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 35
  • 100 (a)
OneToMany
MIA 34
  • 99.49 (n)
dog
(Canis familiaris)
Mammalia MIA 34
  • 89.06 (n)
cow
(Bos Taurus)
Mammalia MIA 34 35
  • 87.69 (n)
mouse
(Mus musculus)
Mammalia Mia 34 16 35
  • 84.62 (n)
Gm21983 35
  • 77 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Mia 34
  • 83.59 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 67 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia mia 34
  • 68.58 (n)
zebrafish
(Danio rerio)
Actinopterygii zgc:194158 34
  • 61.28 (n)
MIA 35
  • 55 (a)
OneToMany
Species where no ortholog for MIA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIA Gene

ENSEMBL:
Gene Tree for MIA (if available)
TreeFam:
Gene Tree for MIA (if available)

Paralogs for MIA Gene

Paralogs for MIA Gene

(4) SIMAP similar genes for MIA Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with MIA: view

Variants for MIA Gene

Sequence variations from dbSNP and Humsavar for MIA Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs111408303 -- 40,773,520(+) GCTGC(A/G)GTGGG upstream-variant-2KB
rs111679146 -- 40,777,517(+) GGGGT(C/G)GGGTA intron-variant, upstream-variant-2KB
rs111819634 -- 40,773,362(+) CGGGA(A/G)GGGGA upstream-variant-2KB
rs111829523 -- 40,773,616(+) CCTGT(-/A)AAAAA upstream-variant-2KB
rs112887231 -- 40,776,045(+) TTTCC(G/T)AGACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MIA Gene

Variant ID Type Subtype PubMed ID
esv26234 CNV loss 19812545
nsv833832 CNV loss 17160897

Variation tolerance for MIA Gene

Residual Variation Intolerance Score: 56.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.88; 18.33% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MIA Gene

Human Gene Mutation Database (HGMD)
MIA
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MIA Gene

Disorders for MIA Gene

MalaCards: The human disease database

(2) MalaCards diseases for MIA Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
skin melanoma
  • melanoma
uveal melanoma
  • melanoma of uvea
- elite association - COSMIC cancer census association via MalaCards
Search MIA in MalaCards View complete list of genes associated with diseases

Relevant External Links for MIA

Genetic Association Database (GAD)
MIA
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIA
genes like me logo Genes that share disorders with MIA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIA Gene

Publications for MIA Gene

  1. Structure and promoter analysis of the gene encoding the human melanoma-inhibiting protein MIA. (PMID: 8550608) Bosserhoff A.-K. … Buettner R. (J. Biol. Chem. 1996) 3 4 22 64
  2. Cloning of a novel malignant melanoma-derived growth-regulatory protein, MIA. (PMID: 7923218) Blesch A. … Bogdahn U. (Cancer Res. 1994) 2 3 4 64
  3. A genome-wide association study identifies three new risk loci for Kawasaki disease. (PMID: 22446962) Onouchi Y. … . (Nat. Genet. 2012) 3 46 64
  4. Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening. (PMID: 19807924) Voss M. … Janssen O. (BMC Immunol. 2009) 3 4 64
  5. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z. … Henzel W.J. (Protein Sci. 2004) 3 4 64

Products for MIA Gene

Sources for MIA Gene

Content
Loading form....