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MIA Gene

protein-coding   GIFtS: 57
GCID: GC19P041283

Melanoma Inhibitory Activity

  See MIA-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Melanoma Inhibitory Activity1 2
CD-RAP2
Melanoma-Derived Growth Regulatory Protein2
Melanoma Inhibitory Activity Protein3

External Ids:    HGNC: 70761   Entrez Gene: 81902   Ensembl: ENSG000002618577   OMIM: 6013405   UniProtKB: Q166743   

Export aliases for MIA gene to outside databases

Previous GC identifers: GC19P041920 GC19P041673 GC19P045958 GC19P045975 GC19P045976 GC19P045978 GC19P037714


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MIA Gene:
MIA (melanoma inhibitory activity) is a protein-coding gene. Diseases associated with MIA include skin melanoma, and oral squamous cell carcinoma. GO annotations related to this gene include growth factor activity. An important paralog of this gene is OTOR.

UniProtKB/Swiss-Prot: MIA_HUMAN, Q16674
Function: Elicits growth inhibition on melanoma cells in vitro as well as some other neuroectodermal tumors,
including gliomas

Gene Wiki entry for MIA (Melanoma inhibitory activity) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011109.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the MIA gene promoter:
         E2F-4   E2F-3a   C/EBPbeta   AP-1   ATF-2   E2F-2   E2F   E2F-1   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMIA promoter sequence
   Search Chromatin IP Primers for MIA

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MIA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.2   Ensembl cytogenetic band:  19q13.2   HGNC cytogenetic band: 19q13.2

MIA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MIA gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P041283:  view genomic region     (about GC identifiers)

Start:
41,277,553 bp from pter      End:
41,283,398 bp from pter
Size:
5,846 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: MIA_HUMAN, Q16674 (See protein sequence)
Recommended Name: Melanoma-derived growth regulatory protein precursor  
Size: 131 amino acids; 14509 Da
Subunit: Interacts with FASLG. Interacts with TMIGD2
3 PDB 3D structures from and Proteopedia for MIA:
1HJD (3D)        1I1J (3D)        1K0X (3D)    
Secondary accessions: Q6FHV3
Alternative splicing: 2 isoforms:  Q16674-1   Q16674-2   

Explore the universe of human proteins at neXtProt for MIA: NX_Q16674

Explore proteomics data for MIA at MOPED

Post-translational modifications: 

  • May possess two intramolecular disulfide bonds1
  • Modification sites at neXtProt

  • See MIA Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001189482.1  NP_006524.1  

    ENSEMBL proteins: 
     ENSP00000472982   ENSP00000470129   ENSP00000469499   ENSP00000263369   ENSP00000470641  
     ENSP00000471439  

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    antibodies-online proteins for MIA (17 products) 

     
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    antibodies-online antibodies for MIA (23 products) 

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    antibodies-online kits for MIA (10 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR001452 SH3_domain
     IPR011511 SH3_2

    Graphical View of Domain Structure for InterPro Entry Q16674

    ProtoNet protein and cluster: Q16674

    1 Blocks protein domain: IPB001452 SH3 domain signature

    UniProtKB/Swiss-Prot: MIA_HUMAN, Q16674
    Similarity: Belongs to the MIA/OTOR family
    Similarity: Contains 1 SH3 domain


    Find genes that share domains with MIA           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MIA_HUMAN, Q16674
    Function: Elicits growth inhibition on melanoma cells in vitro as well as some other neuroectodermal tumors,
    including gliomas

         Genatlas biochemistry entry for MIA:
    melanoma inhibitory activity,11kDa,regulator of cell growth (see TSG19A)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0008083growth factor activity IEA--
         
    Find genes that share ontologies with MIA           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for MIA:
     Synthetic lethal with Ras 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Mia):
     endocrine/exocrine gland  integument  skeleton 

    Find genes that share phenotypes with MIA           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Miatm1Rbu for MIA

       genOway: Develop your customized and physiologically relevant rodent model for MIA

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MIA_HUMAN, Q16674: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space TAS7923218

    Find genes that share ontologies with MIA           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MIA About    
    See pathways by source

    SuperPathContained pathways About
    1Neural Crest Differentiation
    Neural Crest Differentiation


    1 BioSystems Pathway for MIA
        Neural Crest Differentiation



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MIA
    Interactions:

        GeneGlobe Interaction Network for MIA

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for MIA (Q166743 ENSP000002633694) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FN1P027513, ENSP000003468394I2D: score=2 STRING: ENSP00000346839
    FASLGP480233, ENSP000003566944I2D: score=1 STRING: ENSP00000356694
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008283cell proliferation TAS7923218

    Find genes that share ontologies with MIA           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MIA



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MIA gene (2 alternative transcripts): 
    NM_001202553.1  NM_006533.3  

    Unigene Cluster for MIA:

    Melanoma inhibitory activity
    Hs.646364  [show with all ESTs]
    Unigene Representative Sequence: BG765502
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000597600 ENST00000594436 ENST00000597784 ENST00000263369(uc010xvt.1 uc021uuu.1 uc002opb.4)
    ENST00000597140 ENST00000601159 ENST00000593317
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    Additional mRNA sequence: 

    BC005910.1 BT007044.1 CR541648.1 X75450.1 

    6 DOTS entries:

    DT.215114  DT.100792664  DT.121503341  DT.121503423  DT.121503385  DT.91750613 

    Selected AceView cDNA sequences (see all 186):

    CR541648 AI830148 BQ686015 AW793349 BQ279120 AI086169 AW136325 AF498935 
    AA164359 BU538102 AI312115 CA432161 BQ935941 CB961988 BC033081 BM856478 
    AI561007 BQ279167 BU150091 X75450 BM561937 BU956946 AI270301 CA307435 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MIA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCCCCGACT
    MIA Expression
    About this image


    MIA expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             Mesenchymal Condensate Cells Zeugopod
             Zeugopod Growth Plate
     
     Limb (Muscoskeletal System)
             Mesenchymal Condensate Cells Zeugopod
     
     Testis (Reproductive System)
             Pre-Sertoli Cells Testis Cord
     
     Endothelium (Cardiovascular System)
             Mature Endothelial Cells Blood Brain Barrier
     
     Kidney (Urinary System)
             Ureteric Bud Tip Cells Ureteric Bud
    MIA Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MIA Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.646364

    UniProtKB/Swiss-Prot: MIA_HUMAN, Q16674
    Tissue specificity: All malignant melanoma cell lines tested and infrequently in glioma cell lines

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for MIA gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mia1 , 5 melanoma inhibitory activity 15
    melanoma inhibitory activity1
    84.62(n)1
    82.31(a)1
      7 (15.84 cM)5
    125871  NM_019394.31  NP_062267.21 
     271797445 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    67(a)
    1 → many
    LGf(2815365-2818119)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia mia1 melanoma inhibitory activity 68.58(n)
    68.85(a)
      100216293  NM_001142244.1  NP_001135716.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1941581 zgc:194158 61.28(n)
    56.92(a)
      569807  NM_001128754.1  NP_001122226.1 


    ENSEMBL Gene Tree for MIA (if available)
    TreeFam Gene Tree for MIA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MIA gene
    OTOR2  MIA-RAB4B2  
    4 SIMAP similar genes for MIA using alignment to 4 protein entries:     MIA_HUMAN (see all proteins):
    OTOR    MIA3    MIA2    CTAGE5

    Find genes that share paralogs with MIA           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MIA (see all 14)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1827163211,2
    --41279103(+) GGAGGC/TCAAGG 1 -- us2k10--------
    rs1869988911,2
    --41279119(+) GGGTCA/GCTTGA 1 -- us2k10--------
    rs1417885191,2
    --41279142(+) GACACC/TAGCCT 1 -- us2k10--------
    rs1118196341,2
    C--41279267(+) CGGGAG/AGGGGA 1 -- us2k11Minor allele frequency- A:0.50NA 2
    rs1505608261,2
    C--41279293(+) AGATCA/GTGCCA 2 -- us2k10--------
    rs711736771,2
    C--41279359(+) AAAAA-/A/GGAAAT 2 -- us2k11NA 2
    rs3758682271,2
    C--41279360(+) AAAAA-/GAAATT 2 -- us2k10--------
    rs1151180641,2
    F--41279394(+) GCTCAC/TACTTA 2 -- us2k11Minor allele frequency- T:0.06WA 118
    rs26074191,2
    C,F--41279395(-) ATAAGT/CGTGAG 2 -- us2k13Minor allele frequency- C:0.14WA NA EA 358
    rs1114083031,2
    C,F--41279425(+) GCTGCG/AGTGGG 2 -- us2k12Minor allele frequency- A:0.10CSA WA 120

    HapMap Linkage Disequilibrium report for MIA (41277553 - 41283398 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for MIA:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv26234CNV Loss19812545
    nsv833832CNV Loss17160897

    Human Gene Mutation Database (HGMD): MIA
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MIA
    DNA2.0 Custom Variant and Variant Library Synthesis for MIA

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601340    OMIM disorders: --

    3 diseases for MIA:    
    About MalaCards
    skin melanoma    oral squamous cell carcinoma    melanoma

    1 disease from the University of Copenhagen DISEASES database for MIA:
    Melanoma

    Find genes that share disorders with MIA           About GenesLikeMe

    Genetic Association Database (GAD): MIA

    Export disorders for MIA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MIA gene, integrated from 10 sources (see all 43):
    (articles sorted by number of sources associating them with MIA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of a novel malignant melanoma-derived growth-regulatory protein, MIA. (PubMed id 7923218)1, 2, 3 Blesch A.... Bogdahn U. (Cancer Res. 1994)
    2. Structure and promoter analysis of the gene encoding the human melanoma-inhibiting protein MIA. (PubMed id 8550608)1, 2, 9 Bosserhoff A.-K.... Buettner R. (J. Biol. Chem. 1996)
    3. A genome-wide association study identifies three new risk loci for Kawasaki disease. (PubMed id 22446962)1, 4 Onouchi Y.... . (Nat. Genet. 2012)
    4. Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening. (PubMed id 19807924)1, 2 Voss M.... Janssen O. (BMC Immunol. 2009)
    5. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (Protein Sci. 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Cloning and characterization of the expression pattern of a novel splice product MIA (splice) of malignant melanoma-derived growth- inhibiting activity (MIA/CD-RAP). (PubMed id 12230496)1, 2 Hau P.... Apfel R. (J. Invest. Dermatol. 2002)
    8. Structure of melanoma inhibitory activity protein, a member of a recently identified family of secreted proteins. (PubMed id 11331761)1, 2 Lougheed J.C.... Handel T.M. (Proc. Natl. Acad. Sci. U.S.A. 2001)
    9. Assignment of the human melanoma inhibitory activity gene (MIA) to 19q13.32-q13.33 by fluorescence in situ hybridization (FISH). (PubMed id 8661134)1, 3 Koehler M.R....Schmid M. (Genomics 1996)
    10. Melanoma-inhibiting activity (MIA/CD-RAP) is expressed in a variety of malignant tumors of mainly neuroectodermal origin. (PubMed id 12014625)1, 9 Hau P....Bogdahn U. (Anticancer Res. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    NCBI Bookshelf
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8190 HGNC: 7076 AceView: MIAandRAB4B Ensembl:ENSG00000261857 euGenes: HUgn8190
    ECgene: MIA H-InvDB: MIA

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MIA Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MIA Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MIA gene:
    Search GeneIP for patents involving MIA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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