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Aliases for MIA Gene

Aliases for MIA Gene

  • Melanoma Inhibitory Activity 2 3
  • Melanoma-Derived Growth Regulatory Protein 3
  • Melanoma Inhibitory Activity Protein 4
  • CD-RAP 3

External Ids for MIA Gene

Summaries for MIA Gene

GeneCards Summary for MIA Gene

MIA (Melanoma Inhibitory Activity) is a Protein Coding gene. Diseases associated with MIA include melanoma and skin melanoma. Among its related pathways are Neural Crest Differentiation. GO annotations related to this gene include growth factor activity. An important paralog of this gene is MIA-RAB4B.

UniProtKB/Swiss-Prot for MIA Gene

  • Elicits growth inhibition on melanoma cells in vitro as well as some other neuroectodermal tumors, including gliomas

Gene Wiki entry for MIA Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIA Gene

Genomics for MIA Gene

Genomic Location for MIA Gene

Start:
40,771,648 bp from pter
End:
40,777,493 bp from pter
Size:
5,846 bases
Orientation:
Plus strand

Genomic View for MIA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIA Gene

Regulatory Elements for MIA Gene

Proteins for MIA Gene

  • Protein details for MIA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16674-MIA_HUMAN
    Recommended name:
    Melanoma-derived growth regulatory protein
    Protein Accession:
    Q16674
    Secondary Accessions:
    • Q6FHV3

    Protein attributes for MIA Gene

    Size:
    131 amino acids
    Molecular mass:
    14509 Da
    Quaternary structure:
    • Interacts with FASLG. Interacts with TMIGD2.

    Three dimensional structures from OCA and Proteopedia for MIA Gene

    Alternative splice isoforms for MIA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MIA Gene

Proteomics data for MIA Gene at MOPED

Post-translational modifications for MIA Gene

Other Protein References for MIA Gene

No data available for DME Specific Peptides for MIA Gene

Domains for MIA Gene

Protein Domains for MIA Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

MIA_HUMAN
Domain:
  • Contains 1 SH3 domain.:
    • Q16674
Family:
  • Belongs to the MIA/OTOR family.:
    • Q16674
genes like me logo Genes that share domains with MIA: view

No data available for Gene Families for MIA Gene

Function for MIA Gene

Molecular function for MIA Gene

GENATLAS Biochemistry: melanoma inhibitory activity,11kDa,regulator of cell growth (see TSG19A)
UniProtKB/Swiss-Prot Function: Elicits growth inhibition on melanoma cells in vitro as well as some other neuroectodermal tumors, including gliomas

Gene Ontology (GO) - Molecular Function for MIA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0008083 growth factor activity IEA --
genes like me logo Genes that share ontologies with MIA: view

Phenotypes for MIA Gene

genes like me logo Genes that share phenotypes with MIA: view

Animal Models for MIA Gene

MGI Knock Outs for MIA:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for MIA Gene

Localization for MIA Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIA Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MIA Gene COMPARTMENTS Subcellular localization image for MIA gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for MIA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space TAS 7923218
genes like me logo Genes that share ontologies with MIA: view

Pathways for MIA Gene

SuperPathways for MIA Gene

genes like me logo Genes that share pathways with MIA: view

Pathways by source for MIA Gene

1 BioSystems pathway for MIA Gene

Interacting Proteins for MIA Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000263369%0d%0a9606.ENSP00000346839%0d%0a9606.ENSP00000358081%0d%0a
Selected Interacting proteins: ENSP00000263369 Q16674-MIA_HUMAN for MIA Gene via STRING I2D

Gene Ontology (GO) - Biological Process for MIA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008283 cell proliferation TAS 7923218
genes like me logo Genes that share ontologies with MIA: view

Transcripts for MIA Gene

Unigene Clusters for MIA Gene

Melanoma inhibitory activity:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MIA Gene

No ASD Table

Relevant External Links for MIA Gene

GeneLoc Exon Structure for
MIA
ECgene alternative splicing isoforms for
MIA

Expression for MIA Gene

mRNA expression in normal human tissues for MIA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MIA Gene

This gene is overexpressed in Nerve - Tibial (19.5) and Pituitary (9.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for MIA Gene

SOURCE GeneReport for Unigene cluster for MIA Gene Hs.646364

mRNA Expression by UniProt/SwissProt for MIA Gene

Q16674-MIA_HUMAN
Tissue specificity: All malignant melanoma cell lines tested and infrequently in glioma cell lines
genes like me logo Genes that share expressions with MIA: view

Orthologs for MIA Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 37
  • 100 (a)
OneToMany
MIA 36
  • 99.49 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia MIA 36
  • 87.69 (n)
  • 86.15 (a)
MIA 37
  • 86 (a)
OneToMany
dog
(Canis familiaris)
Mammalia MIA 36
  • 89.06 (n)
  • 87.79 (a)
mouse
(Mus musculus)
Mammalia Gm21983 37
  • 77 (a)
ManyToMany
Mia 36
  • 84.62 (n)
  • 82.31 (a)
Mia 16
Mia 37
  • 82 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Mia 36
  • 83.59 (n)
  • 83.85 (a)
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 67 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia mia 36
  • 68.58 (n)
  • 68.85 (a)
zebrafish
(Danio rerio)
Actinopterygii MIA 37
  • 55 (a)
OneToMany
zgc:194158 36
  • 61.28 (n)
  • 56.92 (a)
Species with no ortholog for MIA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIA Gene

ENSEMBL:
Gene Tree for MIA (if available)
TreeFam:
Gene Tree for MIA (if available)

Paralogs for MIA Gene

Paralogs for MIA Gene

Selected SIMAP similar genes for MIA Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with MIA: view

Variants for MIA Gene

Sequence variations from dbSNP and Humsavar for MIA Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs2607419 -- 40,773,490(-) ATAAG(C/T)GTGAG upstream-variant-2KB
rs35547763 -- 40,773,434(+) GTCTC(-/A)AAAAA upstream-variant-2KB
rs60460080 -- 40,773,359(+) ACCCG(A/G)GAGGG upstream-variant-2KB
rs71173677 -- 40,773,454(+) AAAAA(-/A)GAAAT upstream-variant-2KB
rs111408303 -- 40,773,520(+) GCTGC(A/G)GTGGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIA Gene

Variant ID Type Subtype PubMed ID
nsv833832 CNV Loss 17160897
esv26234 CNV Loss 19812545

Relevant External Links for MIA Gene

HapMap Linkage Disequilibrium report
MIA
Human Gene Mutation Database (HGMD)
MIA

Disorders for MIA Gene

(1) University of Copenhagen DISEASES for MIA Gene

Relevant External Links for MIA

Genetic Association Database (GAD)
MIA
genes like me logo Genes that share disorders with MIA: view

No data available for UniProtKB/Swiss-Prot for MIA Gene

Publications for MIA Gene

  1. Cloning of a novel malignant melanoma-derived growth-regulatory protein, MIA. (PMID: 7923218) Blesch A. … Bogdahn U. (Cancer Res. 1994) 2 3 4
  2. Structure and promoter analysis of the gene encoding the human melanoma-inhibiting protein MIA. (PMID: 8550608) Bosserhoff A.-K. … Buettner R. (J. Biol. Chem. 1996) 3 4 23
  3. Melanoma-inhibiting activity (MIA/CD-RAP) is expressed in a variety of malignant tumors of mainly neuroectodermal origin. (PMID: 12014625) Hau P. … Bogdahn U. (Anticancer Res. 2002) 3 23
  4. Structure of melanoma inhibitory activity protein, a member of a recently identified family of secreted proteins. (PMID: 11331761) Lougheed J.C. … Handel T.M. (Proc. Natl. Acad. Sci. U.S.A. 2001) 3 4
  5. Assignment of the human melanoma inhibitory activity gene (MIA) to 19q13.32-q13.33 by fluorescence in situ hybridization (FISH). (PMID: 8661134) Koehler M.R. … Schmid M. (Genomics 1996) 2 3

Products for MIA Gene

Sources for MIA Gene

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