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Aliases for MIA Gene

Aliases for MIA Gene

  • Melanoma Inhibitory Activity 2 3 5
  • Melanoma-Derived Growth Regulatory Protein 3
  • Melanoma Inhibitory Activity Protein 4
  • CD-RAP 3

External Ids for MIA Gene

Previous GeneCards Identifiers for MIA Gene

  • GC19P041920
  • GC19P041673
  • GC19P045958
  • GC19P045975
  • GC19P045976
  • GC19P045978
  • GC19P041283
  • GC19P037714

Summaries for MIA Gene

GeneCards Summary for MIA Gene

MIA (Melanoma Inhibitory Activity) is a Protein Coding gene. Diseases associated with MIA include Melanoma and Skin Melanoma. Among its related pathways are Neural Crest Differentiation. GO annotations related to this gene include growth factor activity. An important paralog of this gene is MIA-RAB4B.

UniProtKB/Swiss-Prot for MIA Gene

  • Elicits growth inhibition on melanoma cells in vitro as well as some other neuroectodermal tumors, including gliomas.

Gene Wiki entry for MIA Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIA Gene

Genomics for MIA Gene

Regulatory Elements for MIA Gene

Enhancers for MIA Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G040747 1.8 FANTOM5 ENCODE dbSUPER 9.5 -18.9 -18887 9.8 MLX CREB3L1 ZFP64 DMAP1 YBX1 FEZF1 YY1 ZNF416 ZNF143 ZNF263 ENSG00000269843 SNRPA ENSG00000205041 FBL COQ8B ITPKC CCDC97 NUMBL C19orf54 SERTAD3
GH19G040776 1.4 ENCODE dbSUPER 12.1 +6.3 6296 3.3 HDGF PKNOX1 FOXA2 CREB3L1 ARNT ZFP64 WRNIP1 ARID4B SIN3A ZNF2 SNRPA PSMC4 C19orf54 MIA RNU6-195P ENSG00000269843 FBL ITPKC CYP2T1P COQ8B
GH19G040713 2.1 FANTOM5 Ensembl ENCODE dbSUPER 6.4 -53.3 -53301 9.2 CREB3L1 DMAP1 FEZF1 YY1 ZNF143 ZNF416 ZNF548 SP3 NFYC SSRP1 SNRPA FBL ITPKC ENSG00000205041 ENSG00000269843 CCDC97 PSMC4 NUMBL COQ8B ENSG00000269069
GH19G040761 0.9 ENCODE dbSUPER 10.5 -9.7 -9670 0.8 ZNF114 ZNF195 ZNF311 NR2F2 POLR2A ZBTB48 ZNF747 PRDM10 ZNF600 ENSG00000269843 SNRPA MIA PSMC4 GC19P040765 C19orf54
GH19G040762 0.7 dbSUPER 10.5 -8.0 -7978 2.0 CTCF ZNF146 ZNF48 ZIC2 ZNF121 GLIS2 POLR2A ZNF239 ZNF600 EGR2 EGLN2 MIA ITPKC C19orf54 GC19P040765
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIA on UCSC Golden Path with GeneCards custom track

Genomic Location for MIA Gene

Chromosome:
19
Start:
40,771,648 bp from pter
End:
40,777,493 bp from pter
Size:
5,846 bases
Orientation:
Plus strand

Genomic View for MIA Gene

Genes around MIA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIA Gene

Proteins for MIA Gene

  • Protein details for MIA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16674-MIA_HUMAN
    Recommended name:
    Melanoma-derived growth regulatory protein
    Protein Accession:
    Q16674
    Secondary Accessions:
    • Q6FHV3

    Protein attributes for MIA Gene

    Size:
    131 amino acids
    Molecular mass:
    14509 Da
    Quaternary structure:
    • Interacts with FASLG. Interacts with TMIGD2.

    Three dimensional structures from OCA and Proteopedia for MIA Gene

    Alternative splice isoforms for MIA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MIA Gene

Post-translational modifications for MIA Gene

Other Protein References for MIA Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for MIA

Assay Products

  • Cloud-Clone Corp. Assay Kits for MIA

No data available for DME Specific Peptides for MIA Gene

Domains & Families for MIA Gene

Gene Families for MIA Gene

Protein Domains for MIA Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for MIA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q16674

UniProtKB/Swiss-Prot:

MIA_HUMAN :
  • Belongs to the MIA/OTOR family.
Family:
  • Belongs to the MIA/OTOR family.
genes like me logo Genes that share domains with MIA: view

Function for MIA Gene

Molecular function for MIA Gene

GENATLAS Biochemistry:
melanoma inhibitory activity,11kDa,regulator of cell growth (see TSG19A)
UniProtKB/Swiss-Prot Function:
Elicits growth inhibition on melanoma cells in vitro as well as some other neuroectodermal tumors, including gliomas.

Gene Ontology (GO) - Molecular Function for MIA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008083 growth factor activity IEA --
genes like me logo Genes that share ontologies with MIA: view
genes like me logo Genes that share phenotypes with MIA: view

Animal Models for MIA Gene

MGI Knock Outs for MIA:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for MIA

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for MIA Gene

Localization for MIA Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIA Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIA gene
Compartment Confidence
extracellular 5
plasma membrane 1

Gene Ontology (GO) - Cellular Components for MIA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space TAS 7923218
genes like me logo Genes that share ontologies with MIA: view

Pathways & Interactions for MIA Gene

SuperPathway Contained pathways
1 Neural Crest Differentiation
genes like me logo Genes that share pathways with MIA: view

Pathways by source for MIA Gene

1 BioSystems pathway for MIA Gene

Interacting Proteins for MIA Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000263369%0d%0a9606.ENSP00000346839%0d%0a
Selected Interacting proteins: ENSP00000263369 Q16674-MIA_HUMAN for MIA Gene via STRING IID

Gene Ontology (GO) - Biological Process for MIA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008283 cell proliferation TAS 7923218
genes like me logo Genes that share ontologies with MIA: view

No data available for SIGNOR curated interactions for MIA Gene

Drugs & Compounds for MIA Gene

No Compound Related Data Available

Transcripts for MIA Gene

Unigene Clusters for MIA Gene

Melanoma inhibitory activity:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for MIA

Alternative Splicing Database (ASD) splice patterns (SP) for MIA Gene

No ASD Table

Relevant External Links for MIA Gene

GeneLoc Exon Structure for
MIA
ECgene alternative splicing isoforms for
MIA

Expression for MIA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MIA Gene

This gene is overexpressed in Nerve - Tibial (x19.5) and Pituitary (x9.7).

Protein differential expression in normal tissues from HIPED for MIA Gene

This gene is overexpressed in Lung (52.1) and Testis (16.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MIA Gene



Protein tissue co-expression partners for MIA Gene

NURSA nuclear receptor signaling pathways regulating expression of MIA Gene:

MIA

SOURCE GeneReport for Unigene cluster for MIA Gene:

Hs.646364

mRNA Expression by UniProt/SwissProt for MIA Gene:

Q16674-MIA_HUMAN
Tissue specificity: All malignant melanoma cell lines tested and infrequently in glioma cell lines.

Evidence on tissue expression from TISSUES for MIA Gene

  • Skin(4.2)
genes like me logo Genes that share expression patterns with MIA: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for MIA Gene

Orthologs for MIA Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 35
  • 100 (a)
OneToMany
MIA 34
  • 99.49 (n)
dog
(Canis familiaris)
Mammalia MIA 34
  • 89.06 (n)
cow
(Bos Taurus)
Mammalia MIA 34 35
  • 87.69 (n)
mouse
(Mus musculus)
Mammalia Mia 34 16 35
  • 84.62 (n)
Gm21983 35
  • 77 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Mia 34
  • 83.59 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 67 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia mia 34
  • 68.58 (n)
zebrafish
(Danio rerio)
Actinopterygii zgc:194158 34
  • 61.28 (n)
MIA 35
  • 55 (a)
OneToMany
Species where no ortholog for MIA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIA Gene

ENSEMBL:
Gene Tree for MIA (if available)
TreeFam:
Gene Tree for MIA (if available)

Paralogs for MIA Gene

Paralogs for MIA Gene

(4) SIMAP similar genes for MIA Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with MIA: view

Variants for MIA Gene

Sequence variations from dbSNP and Humsavar for MIA Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000827255 -- 40,776,547(+) CCAGC(A/C)TGGGC intron-variant, upstream-variant-2KB
rs1000931237 -- 40,776,738(+) CCCTG(C/T)TTCCA intron-variant, upstream-variant-2KB
rs1001399212 -- 40,775,098(+) GTTTC(C/T)GGTAA upstream-variant-2KB
rs1001783863 -- 40,773,318(+) ATCCC(C/T)GCTAC upstream-variant-2KB
rs1002824990 -- 40,776,745(+) TCCAA(-/AATAATAAT)AATAA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIA Gene

Variant ID Type Subtype PubMed ID
esv26234 CNV loss 19812545
nsv833832 CNV loss 17160897

Variation tolerance for MIA Gene

Residual Variation Intolerance Score: 56.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.88; 18.33% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MIA Gene

Human Gene Mutation Database (HGMD)
MIA
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MIA Gene

Disorders for MIA Gene

MalaCards: The human disease database

(3) MalaCards diseases for MIA Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
melanoma
  • malignant melanoma
skin melanoma
  • melanoma
uveal melanoma
  • melanoma of uvea
- elite association - COSMIC cancer census association via MalaCards
Search MIA in MalaCards View complete list of genes associated with diseases

Relevant External Links for MIA

Genetic Association Database (GAD)
MIA
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIA
genes like me logo Genes that share disorders with MIA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIA Gene

Publications for MIA Gene

  1. Structure and promoter analysis of the gene encoding the human melanoma-inhibiting protein MIA. (PMID: 8550608) Bosserhoff A.-K. … Buettner R. (J. Biol. Chem. 1996) 3 4 22 64
  2. Cloning of a novel malignant melanoma-derived growth-regulatory protein, MIA. (PMID: 7923218) Blesch A. … Bogdahn U. (Cancer Res. 1994) 2 3 4 64
  3. A genome-wide association study identifies three new risk loci for Kawasaki disease. (PMID: 22446962) Onouchi Y. … . (Nat. Genet. 2012) 3 46 64
  4. Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening. (PMID: 19807924) Voss M. … Janssen O. (BMC Immunol. 2009) 3 4 64
  5. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z. … Henzel W.J. (Protein Sci. 2004) 3 4 64

Products for MIA Gene

Sources for MIA Gene

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