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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

MGST3 Gene

protein-coding GIFtS: 66
GCID: GC01P165600

microsomal glutathione S-transferase 3

Explore 7 diseases affiliated with
MGST3 via

MalaCards

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Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Microsomal Glutathione S-Transferase 3¹ ²
GST-III¹ ²
Microsomal GST-3² ³
Microsomal GST-III² ³
Microsomal Glutathione S-Transferase III²
EC 2.5.1.18³

External Ids:	HGNC: 7064¹	Entrez Gene: 4259²	Ensembl: ENSG00000143198⁷	OMIM: 604564⁵	UniProtKB: O14880³

Export aliases for MGST3 gene to outside databases

Previous GC identifers: GC01P163234 GC01P161251 GC01P162296 GC01P162787 GC01P162332 GC01P163866 GC01P136847

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MGST3:

This gene encodes a member of the MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) protein

family. Members of this family are involved in the production of leukotrienes and prostaglandin E, important mediators

of inflammation. This gene encodes an enzyme which catalyzes the conjugation of leukotriene A4 and reduced glutathione

to produce leukotriene C4. This enzyme also demonstrates glutathione-dependent peroxidase activity towards lipid

hydroperoxides.(provided by RefSeq, May 2011)

UniProtKB/Swiss-Prot: MGST3_HUMAN, O14880

Function: Also functions as a glutathione peroxidase

Gene Wiki entry for MGST3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_004487.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the MGST3 gene promoter:
Pbx1a Bach2 AP-2gamma E47 C/EBPalpha GATA-1 HNF-1A GATA-6 HNF-1 RSRFC4
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MGST3 promoter sequence

Search SABiosciences Chromatin IP Primers for MGST3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MGST3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q23 Ensembl cytogenetic band: 1q24.1 HGNC cytogenetic band: 1q23

MGST3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MGST3 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P165600: view genomic region (about GC identifiers)

Start:	165,600,098 bp from pter	End:	165,631,033 bp from pter
Size:	30,936 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MGST3_HUMAN, O14880 (See protein sequence)

Recommended Name: Microsomal glutathione S-transferase 3

Size: 152 amino acids; 16516 Da

Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Microsome membrane;

Multi-pass membrane protein (Potential). Microsome membrane; Lipid-anchor (Potential)

Secondary accessions: B2R592 Q6ICN4

Explore the universe of human proteins at neXtProt for MGST3: NX_O14880

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O14880

MGST3 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_004519.1

ENSEMBL proteins:

ENSP00000356864 ENSP00000356863 ENSP00000356860 ENSP00000384372 ENSP00000356859

ENSP00000356858 ENSP00000356861

Reactome Protein details: O14880
Human Recombinant Protein Products:

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	Browse ProSpec Recombinant Proteins
	Uscn Proteins for MGST3

Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005624	membrane fraction	--	--
GO:0005635	nuclear envelope	IBA	--
GO:0005783	endoplasmic reticulum	IBA	--
GO:0005789	endoplasmic reticulum membrane	TAS	--
GO:0005792	microsome	--	--

MGST3 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for MGST3

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

MGST3 for domains About GeneDecksing

2 InterPro domains/families:

IPR023352 MAPEG-like_dom

IPR001129 Membr-assoc_MAPEG

Graphical View of Domain Structure for InterPro Entry O14880

ProtoNet protein and cluster: O14880

2 Blocks protein families:

IPB001129 Membrane-associated proteins in eicosanoid and glutathione metabolism (MAPEG)

IPB003382 Flavoprotein

UniProtKB/Swiss-Prot: MGST3_HUMAN, O14880

Similarity: Belongs to the MAPEG family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: MGST3_HUMAN, O14880

Function: Also functions as a glutathione peroxidase

Catalytic activity: RX + glutathione = HX + R-S-glutathione

Genatlas biochemistry entry for MGST3:

glutathione-S-transferase 3,microsomal,16.5kDa,widely distributed,predominantly expressed in heart,skeletal

muscle,adrenal cortex,microsomal GST superfamily

Enzyme Number (IUBMB): EC 2.5.1.18¹

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		6 QIAGEN miScript miRNA Assays for microRNAs that regulate MGST3:
		hsa-miR-485-5p hsa-miR-582-3p hsa-miR-875-3p hsa-miR-325 hsa-miR-888 hsa-miR-331-5p
		SwitchGear 3'UTR luciferase reporter plasmid: MGST3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Gene Editing
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for MGST3
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MGST3

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004364	glutathione transferase activity	IBA	--
GO:0004601	peroxidase activity	TAS	9278457
GO:0004602	glutathione peroxidase activity	IBA	--
GO:0016740	transferase activity	--	--

MGST3 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for MGST3:

Increased gamma-H2AX phosphory

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Glutathione metabolism

Glutathione metabolism	1.00	glutathione-mediated detoxification I	0.53
Glutathione metabolism	0.92	Glutathione conjugation	0.50
Glutathione metabolism	0.70

Biological oxidations

	Biological oxidations	1.00			metapathway biotransformation	0.41
	Phase II conjugation	0.52

Drug metabolism - cytochrome P450

Drug metabolism - cytochrome P450

1.00

Metabolism of xenobiotics by cytochrome P450

0.73

Arachidonic acid metabolism

HETE and HPETE biosynthesis and metabolism

0.39

HETE and HPETE biosynthesis and metabolism

0.39

Metabolism

Metabolism

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for MGST3

	HETE and HPETE biosynthesis and metabolism
	Glutathione metabolism

2 GeneGo (Thomson Reuters) Pathways for MGST3

	HETE and HPETE biosynthesis and metabolism
	Glutathione metabolism

2 BioSystems Pathways for MGST3

	glutathione-mediated detoxification I
	metapathway biotransformation

4 Reactome Pathways for MGST3

	Metabolism
	Biological oxidations
	Glutathione conjugation
	Phase II conjugation

3 Kegg Pathways (Kegg details for MGST3):

	Glutathione metabolism
	Metabolism of xenobiotics by cytochrome P450
	Drug metabolism - cytochrome P450

MGST3 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for MGST3

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/66 Interacting proteins for MGST3 (O14880³ ENSP00000356859⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 66)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
F10	P00742³, ENSP00000364709⁴	I2D: score=3 STRING: ENSP00000364709
CLN3	Q13286³	I2D: score=1
MLST8	Q9BVC4³	I2D: score=1
CYP1A2	ENSP00000342007⁴	STRING: ENSP00000342007
CYP1B1	ENSP00000260630⁴	STRING: ENSP00000260630

About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006629	lipid metabolic process	TAS	9278457
GO:0006750	glutathione biosynthetic process	IBA	--
GO:0006805	xenobiotic metabolic process	TAS	--
GO:0007165	signal transduction	TAS	9278457
GO:0044281	small molecule metabolic process	TAS	--

MGST3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

MGST3 for compounds About GeneDecksing

EMD Millipore small molecules for MGST3:
Small Molecule - inhibitor

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for MGST3

10/12 HMDB Compounds for MGST3 (see all 12) About this table

Compound	Synonyms	CAS #	PubMed Ids
2-Hydroxyestrone-1-S-glutathione	2,3-dihydroxy-1,3,5[10]-estratriene-17-one-1-S-glutathione;2-hydroxyestrone-1-S-glutathione	--	--
2-Hydroxyestrone-4-S-glutathione	2,3-dihydroxy-1,3,5[10]-estratriene-17-one-4-S-glutathione	--	--
4-Hydroxyestrone-2-S-glutathione	3,4-dihydroxy-1,3,5[10]-estratriene-17-one-2-S-glutathione	--	--
Adrenochrome	adrenochrome oxidised;adrenochrome O-quinone;N-methyl-5,6-dioxo-2,3,5,6-tetrahydro-3-hydroxyindole;N-methyl-5,6-dioxo-2,3,5,6-tetrahydro-3-indolol;AdChr	54-06-8	--
Estrone-2,3-quinone	catecholestrogen quinone	40551-33-5	--
Estrone-3,4-quinone	catecholestrogen quinone	633-34-1	--
Glutathione	5-L-Glutamyl-L-cysteinylglycine (see all 32)	70-18-8	--
Hydrochloric acid	Hydrogen chloride anhydrous [UN1050] [Poison gas] (see all 16)	7647-01-0	--
Noradrenochrome	noradrenochrome O-quinone;noradrenochrome oxidised;5,6-dioxo-2,3,5,6-tetrahydro-3-hydroxyindole;5,6-dioxo-2,3,5,6-tetrahydro-3-indolol;AdChr	490-89-1	--
S-(PGJ2)-glutathione	GSPGJ2;9-(S-glutathionyl)-prostaglandin J(,2)	--	--

1 DrugBank Compound for MGST3 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Glutathione	5-L-Glutamyl-L-cysteinylglycine (see all 5)	70-18-8	target	--	17632548

1 Novoseek chemical compound relationship for MGST3 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
ltc4	71.3	4	9278457 (3), 11322876 (1)

Search CenterWatch for drugs/clinical trials and news about MGST3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MGST3 gene:

NM_004528.3

Unigene Clusters for MGST3:

Microsomal glutathione S-transferase 3

Hs.191734 [show with all ESTs], Hs.732686 [show with all ESTs]

Unigene Representative Sequences: BX537737, BX337020

14 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000367889(uc001gdf.3) ENST00000367888 ENST00000461308 ENST00000460632

ENST00000495447 ENST00000367885 ENST00000404549 ENST00000367884 ENST00000488688

ENST00000367883 ENST00000461759 ENST00000477450 ENST00000494074 ENST00000367886

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MGST3
		6 QIAGEN miScript miRNA Assays for microRNAs that regulate MGST3:
		hsa-miR-485-5p hsa-miR-582-3p hsa-miR-875-3p hsa-miR-325 hsa-miR-888 hsa-miR-331-5p
		SwitchGear 3'UTR luciferase reporter plasmid: MGST3 3' UTR sequence

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MGST3

Additional cDNA sequence: DQ185045.1

18 DOTS entries:

DT.95154903 DT.75153859 DT.75102318 DT.99933683 DT.100772862 DT.453552 DT.91770320 DT.40121738

DT.95154913 DT.91770329 DT.91770337 DT.92325950 DT.100759869 DT.121391841 DT.65287149 DT.75160635

DT.91770335 DT.121391833

24/569 AceView cDNA sequences (see all 569):

AA354180 AI141671 CR607567 CB131991 AI695763 H97313 AA609721 BM687266

BM708026 BU731426 AI129537 BC003034 AI083901 F34708 N91998 AA603767

BU730088 BM692218 BX113433 AI913723 AL696703 BF220082 BM668685 AW157190

GeneLoc Exon Structure

5/12 Alternative Splicing Database (ASD) splice patterns (SP) for MGST3 (see all 12) About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4	^	5a	·	5b	·	5c	·	5d	^	6	^	7a	·	7b	·	7c	^	8	^	9	^	10	^	11a	·	11b	^	12a	·	12b	·	12c	·	12d
SP1:							-		-		-		-						-		-						-				-		-
SP2:							-		-		-		-						-		-						-				-		-		-
SP3:									-		-		-						-		-						-				-		-
SP4:																			-		-		-				-				-		-
SP5:							-		-		-								-		-						-				-		-

ECgene alternative splicing isoforms for MGST3

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MGST3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TACAGCACGG

About this image

MGST3 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Liver

Liver Lobule

Liver

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See MGST3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MGST3

SOURCE GeneReport for Unigene clusters: Hs.191734 Hs.732686

UniProtKB/Swiss-Prot: MGST3_HUMAN, O14880

Tissue specificity: Predominantly expressed in heart, skeletal muscle, and adrenal cortex. Also found in brain,

placenta, liver, kidney, pancreas, thyroid, testis and ovary. Almost absent in lung, thymus and peripheral blood

leukocytes

SABiosciences Expression via Pathway-Focused PCR Arrays including MGST3:

Oxidative Stress in human mouse rat

Drug Metabolism: Phase II Enzymes in human mouse rat

Drug Metabolism in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MGST3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for MGST3 gene from 7/23 species (see all 23) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Mgst3^{1 , 5}	microsomal glutathione S-transferase 3^{1, 5}	83.77(n)¹ 86.18(a)¹		1 (74.76 cM)⁵ 66447¹ NM_025569.1¹ NP_079845.1¹ 167371966⁵
chicken (Gallus gallus)	Aves	MGST3¹	microsomal glutathione S-transferase 3	74.29(n) 80(a)		424404 XM_001232859.2 XP_001232860.1
lizard (Anolis carolinensis)	Reptilia	MGST3⁶	--	78(a)	1 ↔ 1	GL343405.1(185306-196100)
African clawed frog (Xenopus laevis)	Amphibia	Xl.11525²	Xenopus laevis transcribed sequence with moderate similarity more	75.06(n)		CF519859.1
zebrafish (Danio rerio)	Actinopterygii	mgst3¹	microsomal glutathione S-transferase 3	60.43(n) 64.75(a)		406736 NM_213427.1 NP_998592.1
thale cress (Arabidopsis thaliana)	eudicotyledons	AT1G65820¹	glutathione S-transferase	53.02(n) 42.52(a)		842893 NM_105255.2 NP_176758.1
rice (Oryza sativa)	Liliopsida	Os03g0709000¹	hypothetical protein	53.12(n) 45.31(a)		4333870 NM_001057577.1 NP_001051042.1

ENSEMBL Gene Tree for MGST3 (if available)
TreeFam Gene Tree for MGST3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs6672982^1,2	C,F,	--	136860295(+)	`aaataT/Aacata`	1	--	us2k¹		9		NA WA CSA EA	370
rs61800391^1,2		--	136860370(+)	`TTGAGG/ACCAGG`	1	--	us2k¹		1		NA	2
rs34340940^1,2		--	136860457(+)	`GCGGGC/TGCCTG`	1	--	us2k¹		0	--	--	--	--
rs112531005^1,2	C,F,	--	136860543(+)	`TTGTGC/TCACTG`	1	--	us2k¹		2		WA CSA	4
rs73028722^1,2	C,	--	136861074(+)	`AGGCAG/ATTGTA`	1	--	us2k¹		1		WA	2
rs9333439^1,2	C,F,	--	136861141(+)	`gtaacA/Tatatg`	1	--	us2k¹		1		NS	176
rs9333440^1,2	C,	--	136861169(+)	`tggtaC/Tacctg`	1	--	us2k¹		1		NS	176
rs11591043^1,2	C,F,H	--	136861261(+)	`gcctaG/Tggcat`	1	--	us2k¹		5		NS EA NA	420
rs9333441^1,2	C,F,	--	136861291(+)	`CCTTAC/AGTACA`	1	--	us2k¹		4		NS WA NA	416
rs9333442^1,2	C,F,	--	136861292(+)	`CTTACG/ATACAC`	1	--	us2k¹		4		NS NA WA	298

HapMap Linkage Disequilibrium report for MGST3 (165600098 - 165631033 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for MGST3
1 Indel: 65129
Human Gene Mutation Database (HGMD): MGST3

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

MGST3 for disorders           About GeneDecksing

OMIM gene information: 604564    OMIM disorders: --

7 diseases for MGST3:    About MalaCards

essential hypertension hypertension t-cell leukemia alzheimer's disease

leukemia neuroblastoma thyroiditis

Genetic Association Database (GAD): MGST3
Human Genome Epidemiology (HuGE) Navigator: MGST3 (5 documents)

Export disorders for MGST3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for MGST3 gene, integrated from 9 sources (see all 33):
(articles sorted by number of sources associating them with MGST3)

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Identification and characterization of a novel microsomal enzyme with glutathione-dependent transferase and peroxidase activities. (PubMed id 9278457)^{1, 2, 3, 9} Jakobsson P.-J.... Ford-Hutchinson A.W. (1997)
Evaluation of the microsomal glutathione S-transferase 3 (MGST3) locus on 1q23 as a Type 2 diabetes susceptibility gene in Pima Indians. (PubMed id 12898215)^{1, 4, 9} Thameem F....Prochazka M. (2003)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{1, 2} Gregory S.G.... Bentley D.R. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)
Shotgun proteomics and network analysis of ubiquitin-r elated proteins from human breast carcinoma epithelial cells. (PubMed id 21853274)¹ Zhou J....Liang S. (2012)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)
A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)¹ Wagner S.A....Choudhary C. (2011)
Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (2011)
Site-specific analysis of protein S-acylation by resin-assisted capture. (PubMed id 21044946)² Forrester M.T.... Casey P.J. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 4259	HGNC: 7064	AceView: MGST3	Ensembl:ENSG00000143198	euGenes: HUgn4259
ECgene: MGST3	Kegg: 4259	H-InvDB: MGST3

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for MGST3	Pharmacogenomics, SNPs, Pathways
NIEHS-SNPs	http://egp.gs.washington.edu/data/mgst3/

Intellectual Property for MGST3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for MGST3 gene:
Search GeneIP for patents involving MGST3

GeneCards and IP:
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microsomal glutathione S-transferase 3

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MGST3 Gene

microsomal glutathione S-transferase 3

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