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Aliases for MGST3 Gene

Aliases for MGST3 Gene

  • Microsomal Glutathione S-Transferase 3 2 3 5
  • Microsomal GST-III 2 3 4
  • Microsomal GST-3 2 3 4
  • Microsomal Glutathione S-Transferase III 2 3
  • EC 2.5.1.18 4
  • GST-III 3

External Ids for MGST3 Gene

Previous GeneCards Identifiers for MGST3 Gene

  • GC01P163234
  • GC01P161251
  • GC01P162296
  • GC01P162787
  • GC01P162332
  • GC01P163866
  • GC01P136847

Summaries for MGST3 Gene

Entrez Gene Summary for MGST3 Gene

  • This gene encodes a member of the MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) protein family. Members of this family are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. This gene encodes an enzyme which catalyzes the conjugation of leukotriene A4 and reduced glutathione to produce leukotriene C4. This enzyme also demonstrates glutathione-dependent peroxidase activity towards lipid hydroperoxides.[provided by RefSeq, May 2011]

GeneCards Summary for MGST3 Gene

MGST3 (Microsomal Glutathione S-Transferase 3) is a Protein Coding gene. Among its related pathways are Cytochrome P450 - arranged by substrate type and Drug metabolism - cytochrome P450. GO annotations related to this gene include glutathione transferase activity and glutathione peroxidase activity.

UniProtKB/Swiss-Prot for MGST3 Gene

  • Also functions as a glutathione peroxidase.

Gene Wiki entry for MGST3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MGST3 Gene

Genomics for MGST3 Gene

Regulatory Elements for MGST3 Gene

Enhancers for MGST3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F165629 1.1 ENCODE 43.9 +1.3 1264 4.6 HDGF ARNT CREB3L1 MLX WRNIP1 ARID4B SIN3A ZNF2 YY1 ZNF766 MGST3 LOC284685 LRRC52 ENSG00000236364 ALDH9A1 ENSG00000206990 GC01M165662
GH01F165601 1 Ensembl ENCODE 30.6 -29.0 -28961 0.6 ELF3 CTCF WRNIP1 RAD21 RFX5 YY1 ZNF366 SMC3 MIXL1 ZNF263 MGST3 LRRC52 RXRG ENSG00000236206
GH01F165644 1 Ensembl ENCODE 21 +15.5 15495 3.2 KLF1 ZNF146 TAL1 CEBPG RARA YY1 ZNF121 NCOR1 HNF4G NFE2 MGST3 GC01M165662 ENSG00000206990
GH01F165636 0.9 Ensembl ENCODE 21.8 +6.6 6576 2.5 MTA2 CEBPB CEBPG RAD21 NR2F2 YY1 ATF3 HNF4G ZBTB33 MGST3 GC01M165662 ENSG00000206990
GH01F165392 1.2 Ensembl ENCODE 11.4 -237.5 -237507 0.9 PKNOX1 ZNF2 GLIS2 ZNF143 KLF7 SP3 TSHZ1 REST ZNF610 SMARCA4 MGST3 LMX1A GC01M165392
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MGST3 on UCSC Golden Path with GeneCards custom track

Promoters for MGST3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000546900 1139 4001 HDGF ARNT CREB3L1 MLX WRNIP1 ZFP64 ARID4B SIN3A ZNF2 YY1

Genomic Location for MGST3 Gene

Chromosome:
1
Start:
165,630,861 bp from pter
End:
165,661,796 bp from pter
Size:
30,936 bases
Orientation:
Plus strand

Genomic View for MGST3 Gene

Genes around MGST3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MGST3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MGST3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MGST3 Gene

Proteins for MGST3 Gene

  • Protein details for MGST3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14880-MGST3_HUMAN
    Recommended name:
    Microsomal glutathione S-transferase 3
    Protein Accession:
    O14880
    Secondary Accessions:
    • B2R592
    • Q6ICN4

    Protein attributes for MGST3 Gene

    Size:
    152 amino acids
    Molecular mass:
    16516 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MGST3 Gene

Post-translational modifications for MGST3 Gene

  • Ubiquitination at Lys 111
  • Modification sites at PhosphoSitePlus

Other Protein References for MGST3 Gene

No data available for DME Specific Peptides for MGST3 Gene

Domains & Families for MGST3 Gene

Gene Families for MGST3 Gene

Suggested Antigen Peptide Sequences for MGST3 Gene

Graphical View of Domain Structure for InterPro Entry

O14880

UniProtKB/Swiss-Prot:

MGST3_HUMAN :
  • Belongs to the MAPEG family.
Family:
  • Belongs to the MAPEG family.
genes like me logo Genes that share domains with MGST3: view

Function for MGST3 Gene

Molecular function for MGST3 Gene

GENATLAS Biochemistry:
glutathione-S-transferase 3,microsomal,16.5kDa,widely distributed,predominantly expressed in heart,skeletal muscle,adrenal cortex,microsomal GST superfamily
UniProtKB/Swiss-Prot CatalyticActivity:
RX + glutathione = HX + R-S-glutathione.
UniProtKB/Swiss-Prot Function:
Also functions as a glutathione peroxidase.

Enzyme Numbers (IUBMB) for MGST3 Gene

Gene Ontology (GO) - Molecular Function for MGST3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004364 glutathione transferase activity TAS --
GO:0004601 peroxidase activity TAS 9278457
GO:0004602 glutathione peroxidase activity IBA --
GO:0005515 protein binding IPI 25416956
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with MGST3: view
genes like me logo Genes that share phenotypes with MGST3: view

Animal Models for MGST3 Gene

MGI Knock Outs for MGST3:

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MGST3 Gene

Localization for MGST3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MGST3 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein. Microsome membrane; Multi-pass membrane protein. Microsome membrane; Lipid-anchor.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MGST3 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 5
nucleus 3
mitochondrion 2
cytosol 2
plasma membrane 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for MGST3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005635 nuclear envelope IBA --
GO:0005783 endoplasmic reticulum IBA --
GO:0005789 endoplasmic reticulum membrane IEA,TAS --
GO:0016020 membrane IEA,IDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MGST3: view

Pathways & Interactions for MGST3 Gene

genes like me logo Genes that share pathways with MGST3: view

Gene Ontology (GO) - Biological Process for MGST3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process TAS 9278457
GO:0006805 xenobiotic metabolic process TAS --
GO:0007165 signal transduction TAS 9278457
GO:0010243 response to organonitrogen compound IEA --
GO:0098869 cellular oxidant detoxification IEA --
genes like me logo Genes that share ontologies with MGST3: view

No data available for SIGNOR curated interactions for MGST3 Gene

Drugs & Compounds for MGST3 Gene

(4) Drugs for MGST3 Gene - From: DrugBank, ApexBio, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glutathione Approved Nutra Target 0
Water Approved Pharma 0
Ezatiostat hydrochloride Pharma GST inhibitor 0
Trichloroethylene Pharma 5

(40) Additional Compounds for MGST3 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(1R)-Glutathionyl-(2R)-hydroxy-1,2-dihydronaphthalene
(1R)-Hydroxy-(2R)-glutathionyl-1,2-dihydronaphthalene
(1S)-Hydroxy-(2S)-glutathionyl-1,2-dihydronaphthalene
(1S,2R)-Naphthalene 1,2-oxide
1,1-Dichloroethylene epoxide

(1) ApexBio Compounds for MGST3 Gene

Compound Action Cas Number
Ezatiostat hydrochloride GST inhibitor 286942-97-0
genes like me logo Genes that share compounds with MGST3: view

Transcripts for MGST3 Gene

Unigene Clusters for MGST3 Gene

Microsomal glutathione S-transferase 3:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MGST3 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c · 12d
SP1: - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - - -
SP4: - - - - - -
SP5: - - - - - - - -
SP6: - - - - - - -
SP7: - - - - - - -
SP8: - - - - - -
SP9: -
SP10:
SP11: - - - -
SP12: - -

Relevant External Links for MGST3 Gene

GeneLoc Exon Structure for
MGST3
ECgene alternative splicing isoforms for
MGST3

Expression for MGST3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MGST3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MGST3 Gene

This gene is overexpressed in Nasal epithelium (22.3), Heart (8.0), and Fetal heart (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MGST3 Gene



Protein tissue co-expression partners for MGST3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MGST3 Gene:

MGST3

SOURCE GeneReport for Unigene cluster for MGST3 Gene:

Hs.191734

mRNA Expression by UniProt/SwissProt for MGST3 Gene:

O14880-MGST3_HUMAN
Tissue specificity: Predominantly expressed in heart, skeletal muscle, and adrenal cortex. Also found in brain, placenta, liver, kidney, pancreas, thyroid, testis and ovary. Almost absent in lung, thymus and peripheral blood leukocytes.
genes like me logo Genes that share expression patterns with MGST3: view

No data available for mRNA differential expression in normal tissues for MGST3 Gene

Orthologs for MGST3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MGST3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MGST3 34 35
  • 99.78 (n)
dog
(Canis familiaris)
Mammalia MGST3 34 35 35
  • 91.01 (n)
cow
(Bos Taurus)
Mammalia MGST3 34 35
  • 89.04 (n)
rat
(Rattus norvegicus)
Mammalia Mgst3 34
  • 84.65 (n)
mouse
(Mus musculus)
Mammalia Mgst3 34 16 35
  • 83.77 (n)
oppossum
(Monodelphis domestica)
Mammalia MGST3 35
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MGST3 35
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves MGST3 34 35
  • 74.29 (n)
lizard
(Anolis carolinensis)
Reptilia MGST3 35
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mgst3 34
  • 71.43 (n)
Str.10366 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.11525 34
zebrafish
(Danio rerio)
Actinopterygii mgst3 34 35
  • 60.43 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13985 34
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G65820 34
  • 53.02 (n)
rice
(Oryza sativa)
Liliopsida Os03g0709000 34
  • 53.12 (n)
Species where no ortholog for MGST3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MGST3 Gene

ENSEMBL:
Gene Tree for MGST3 (if available)
TreeFam:
Gene Tree for MGST3 (if available)

Paralogs for MGST3 Gene

(1) SIMAP similar genes for MGST3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with MGST3: view

No data available for Paralogs for MGST3 Gene

Variants for MGST3 Gene

Sequence variations from dbSNP and Humsavar for MGST3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10102 -- 165,655,576(+) ttttt(C/T)taaat utr-variant-3-prime
rs10603252 -- 165,647,727(+) ACACC(-/T)TTTTT intron-variant
rs10737515 -- 165,630,223(+) GGTGA(A/G)GAATC upstream-variant-2KB
rs10737516 -- 165,645,512(+) ATAAT(A/G)CTAAA intron-variant
rs10800118 -- 165,630,537(+) TCTGG(C/G)TCGCG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MGST3 Gene

Variant ID Type Subtype PubMed ID
dgv611n54 CNV loss 21841781
dgv612n54 CNV loss 21841781
esv28160 CNV loss 19812545
nsv548090 CNV loss 21841781
nsv548096 CNV loss 21841781

Variation tolerance for MGST3 Gene

Residual Variation Intolerance Score: 50.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.18; 39.44% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MGST3 Gene

Human Gene Mutation Database (HGMD)
MGST3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MGST3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MGST3 Gene

Disorders for MGST3 Gene

Relevant External Links for MGST3

Genetic Association Database (GAD)
MGST3
Human Genome Epidemiology (HuGE) Navigator
MGST3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MGST3

No disorders were found for MGST3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MGST3 Gene

Publications for MGST3 Gene

  1. Identification and characterization of a novel microsomal enzyme with glutathione-dependent transferase and peroxidase activities. (PMID: 9278457) Jakobsson P.-J. … Ford-Hutchinson A.W. (J. Biol. Chem. 1997) 2 3 4 22 64
  2. Evaluation of the microsomal glutathione S-transferase 3 (MGST3) locus on 1q23 as a Type 2 diabetes susceptibility gene in Pima Indians. (PMID: 12898215) Thameem F. … Prochazka M. (Hum. Genet. 2003) 3 22 46 64
  3. Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease. (PMID: 21116278) Furney S.J. … . (Mol. Psychiatry 2011) 3 46 64
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  5. Pre-B-cell leukemia homeobox 1 (PBX1) shows functional and possible genetic association with bone mineral density variation. (PMID: 19064610) Cheung C.L. … Kung A.W. (Hum. Mol. Genet. 2009) 3 46 64

Products for MGST3 Gene

Sources for MGST3 Gene

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