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MGST3 Gene

protein-coding   GIFtS: 67
GCID: GC01P165600

Microsomal Glutathione S-Transferase 3

  Search for MGST3
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Microsomal Glutathione S-Transferase 31 2
Microsomal GST-31 2 3
Microsomal GST-III1 2 3
Microsomal Glutathione S-Transferase III1 2
GST-III2
EC 2.5.1.183

External Ids:    HGNC: 70641   Entrez Gene: 42592   Ensembl: ENSG000001431987   OMIM: 6045645   UniProtKB: O148803   

Export aliases for MGST3 gene to outside databases

Previous GC identifers: GC01P163234 GC01P161251 GC01P162296 GC01P162787 GC01P162332 GC01P163866 GC01P136847


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MGST3 Gene:
This gene encodes a member of the MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism)
protein family. Members of this family are involved in the production of leukotrienes and prostaglandin E,
important mediators of inflammation. This gene encodes an enzyme which catalyzes the conjugation of leukotriene
A4 and reduced glutathione to produce leukotriene C4. This enzyme also demonstrates glutathione-dependent
peroxidase activity towards lipid hydroperoxides.(provided by RefSeq, May 2011)

GeneCards Summary for MGST3 Gene:
MGST3 (microsomal glutathione S-transferase 3) is a protein-coding gene. GO annotations related to this gene include glutathione transferase activity and glutathione peroxidase activity.

UniProtKB/Swiss-Prot: MGST3_HUMAN, O14880
Function: Also functions as a glutathione peroxidase

Gene Wiki entry for MGST3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MGST3 gene promoter:
         Pbx1a   Bach2   AP-2gamma   E47   C/EBPalpha   GATA-1   HNF-1A   GATA-6   HNF-1   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMGST3 promoter sequence
   Search Chromatin IP Primers for MGST3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MGST3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q23   Ensembl cytogenetic band:  1q24.1   HGNC cytogenetic band: 1q23

MGST3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MGST3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P165600:  view genomic region     (about GC identifiers)

Start:
165,600,098 bp from pter      End:
165,631,033 bp from pter
Size:
30,936 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MGST3_HUMAN, O14880 (See protein sequence)
Recommended Name: Microsomal glutathione S-transferase 3  
Size: 152 amino acids; 16516 Da
Secondary accessions: B2R592 Q6ICN4

Explore the universe of human proteins at neXtProt for MGST3: NX_O14880

Explore proteomics data for MGST3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys111
  • Modification sites at PhosphoSitePlus

  • See MGST3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004519.1  
    ENSEMBL proteins: 
     ENSP00000356864   ENSP00000356863   ENSP00000356860   ENSP00000356859   ENSP00000356858  
     ENSP00000356861  
    Reactome Protein details: O14880

    MGST3 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Protein Over-expression Lysate for MGST3
    OriGene Custom MassSpec
    OriGene Custom Protein Services for MGST3
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    Novus Biologicals MGST3 Proteins
    Novus Biologicals MGST3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MGST3

     
    Search eBioscience for Proteins for MGST3 

    MGST3 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for MGST3
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    Abcam antibodies for MGST3
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    ThermoFisher Antibodies for MGST3
    LSBio Antibodies in human, mouse, rat for MGST3

    MGST3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MGST3
    Cloud-Clone Corp. CLIAs for MGST3
    Search eBioscience for ELISAs for MGST3 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    MGST: Glutathione S-transferases / Microsomal

    2 InterPro protein domains:
     IPR023352 MAPEG-like_dom
     IPR001129 Membr-assoc_MAPEG

    Graphical View of Domain Structure for InterPro Entry O14880

    ProtoNet protein and cluster: O14880

    2 Blocks protein domains:
    IPB001129 Membrane-associated proteins in eicosanoid and glutathione metabolism (MAPEG)
    IPB003382 Flavoprotein


    UniProtKB/Swiss-Prot: MGST3_HUMAN, O14880
    Similarity: Belongs to the MAPEG family


    Find genes that share domains with MGST3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MGST3_HUMAN, O14880
    Function: Also functions as a glutathione peroxidase
    Catalytic activity: RX + glutathione = HX + R-S-glutathione

         Genatlas biochemistry entry for MGST3:
    glutathione-S-transferase 3,microsomal,16.5kDa,widely distributed,predominantly expressed in heart,skeletal
    muscle,adrenal cortex,microsomal GST superfamily

         Enzyme Number (IUBMB): EC 2.5.1.181

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004364glutathione transferase activity IBA--
    GO:0004601peroxidase activity TAS9278457
    GO:0004602glutathione peroxidase activity IBA--
         
    Find genes that share ontologies with MGST3           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for MGST3:
     Increased gamma-H2AX phosphory 

         1 MGI phenotypic allele for Mgst3 (no phenotypes)

    Find genes that share phenotypes with MGST3           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MGST3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MGST3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MGST3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MGST3

    miRNA
    Products:
        
    miRTarBase miRNAs that target MGST3:
    hsa-mir-26b-5p (MIRT029259)

    Block miRNA regulation of human, mouse, rat MGST3 using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate MGST3:
    hsa-miR-485-5p hsa-miR-582-3p hsa-miR-875-3p hsa-miR-325 hsa-miR-888 hsa-miR-331-5p
    SwitchGear 3'UTR luciferase reporter plasmidMGST3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MGST3
    Predesigned siRNA for gene silencing in human, mouse, rat MGST3

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for MGST3

    Clone
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    GenScript: all cDNA clones in your preferred vector: MGST3 (NM_004528)
    Sino Biological Human cDNA Clone for MGST3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MGST3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MGST3

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MGST3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MGST3_HUMAN, O14880: Endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Microsome membrane;
    Multi-pass membrane protein (Potential). Microsome membrane; Lipid-anchor (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    nucleus3
    extracellular2
    cytosol1
    mitochondrion1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005635nuclear envelope IBA--
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0016020membrane TAS9278457
    GO:0016021integral component of membrane IEA--
    GO:0043231intracellular membrane-bounded organelle TAS9278457

    Find genes that share ontologies with MGST3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MGST3 About    
    See pathways by source

    SuperPathContained pathways About
    1Glutathione metabolism
    Glutathione metabolism0.65
    Glutathione conjugation0.60
    Glutathione metabolism0.65
    glutathione-mediated detoxification I0.42
    2Biological oxidations
    Biological oxidations0.56
    metapathway biotransformation0.42
    Phase II conjugation0.56
    3Chemical carcinogenesis
    Chemical carcinogenesis0.71
    Drug metabolism - cytochrome P4500.69
    Metabolism of xenobiotics by cytochrome P4500.71
    4Metabolism
    Metabolism0.38
    5Arachidonic acid metabolism
    HETE and HPETE biosynthesis and metabolism0.33


    Find genes that share SuperPaths with MGST3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 GeneGo (Thomson Reuters) Pathways for MGST3
        HETE and HPETE biosynthesis and metabolism
    Glutathione metabolism

    2 BioSystems Pathways for MGST3
        glutathione-mediated detoxification I
    metapathway biotransformation


    1 Reactome Pathway for MGST3
        Glutathione conjugation


    4 Kegg Pathways  (Kegg details for MGST3):
        Glutathione metabolism
    Metabolism of xenobiotics by cytochrome P450
    Drug metabolism - cytochrome P450
    Chemical carcinogenesis

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MGST3: 
              Oxidative Stress in human mouse rat
              Drug Metabolism: Phase II Enzymes in human mouse rat
              Drug Metabolism in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for MGST3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MGST3 (O148803 ENSP000003568594) via UniProtKB, MINT, STRING, and/or I2D (see all 66)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    F10P007423, ENSP000003647094I2D: score=3 STRING: ENSP00000364709
    CLN3Q132863I2D: score=1 
    MLST8Q9BVC43I2D: score=1 
    CYP1A2ENSP000003420074STRING: ENSP00000342007
    CYP1B1ENSP000002606304STRING: ENSP00000260630
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006629lipid metabolic process TAS9278457
    GO:0006805xenobiotic metabolic process TAS--
    GO:0007165signal transduction TAS9278457
    GO:0044281small molecule metabolic process TAS--
    GO:0055114oxidation-reduction process TAS9278457

    Find genes that share ontologies with MGST3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MGST3

    Selected HMDB Compounds for MGST3 (see all 12)    About this table
    CompoundSynonyms CAS #PubMed Ids
    2-Hydroxyestrone-1-S-glutathione2,3-dihydroxy-1,3,5[10]-estratriene-17-one-1-S-glutathione;2-hydroxyestrone-1-S-glutathione ----
    2-Hydroxyestrone-4-S-glutathione2,3-dihydroxy-1,3,5[10]-estratriene-17-one-4-S-glutathione ----
    4-Hydroxyestrone-2-S-glutathione3,4-dihydroxy-1,3,5[10]-estratriene-17-one-2-S-glutathione ----
    Adrenochromeadrenochrome oxidised;adrenochrome O-quinone;N-methyl-5,6-dioxo-2,3,5,6-tetrahydro-3-hydroxyindole;N-methyl-5,6-dioxo-2,3,5,6-tetrahydro-3-indolol;AdChr 54-06-8--
    Estrone-2,3-quinonecatecholestrogen quinone 40551-33-5--
    Estrone-3,4-quinonecatecholestrogen quinone 633-34-1--
    Glutathione5-L-Glutamyl-L-cysteinylglycine (see all 32)70-18-8--
    Hydrochloric acidHydrogen chloride anhydrous [UN1050] [Poison gas] (see all 16)7647-01-0--
    Noradrenochromenoradrenochrome O-quinone;noradrenochrome oxidised;5,6-dioxo-2,3,5,6-tetrahydro-3-hydroxyindole;5,6-dioxo-2,3,5,6-tetrahydro-3-indolol;AdChr 490-89-1--
    S-(PGJ2)-glutathioneGSPGJ2;9-(S-glutathionyl)-prostaglandin J(,2) ----

    1 DrugBank Compound for MGST3    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Glutathione5-L-Glutamyl-L-cysteinylglycine (see all 5)70-18-8target--17632548

    1 Novoseek inferred chemical compound relationship for MGST3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ltc4 71.3 4 9278457 (3), 11322876 (1)



    Find genes that share compounds with MGST3           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MGST3 gene: 
    NM_004528.3  

    Unigene Cluster for MGST3:

    Microsomal glutathione S-transferase 3
    Hs.191734  [show with all ESTs]
    Unigene Representative Sequence: BX537737
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367889(uc001gdf.3) ENST00000367888 ENST00000461308 ENST00000460632
    ENST00000495447 ENST00000367885 ENST00000367884 ENST00000488688 ENST00000367883
    ENST00000461759 ENST00000609263 ENST00000477450 ENST00000494074 ENST00000367886

    miRNA
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    Block miRNA regulation of human, mouse, rat MGST3 using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate MGST3:
    hsa-miR-485-5p hsa-miR-582-3p hsa-miR-875-3p hsa-miR-325 hsa-miR-888 hsa-miR-331-5p
    SwitchGear 3'UTR luciferase reporter plasmidMGST3 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MGST3
    Predesigned siRNA for gene silencing in human, mouse, rat MGST3
    Clone
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    OriGene clones in human, mouse for MGST3 (see all 6)
    OriGene ORF clones in mouse, rat for MGST3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MGST3 (NM_004528)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MGST3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MGST3
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for MGST3
    OriGene qSTAR qPCR primer pairs in human, mouse for MGST3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MGST3
      QuantiTect SYBR Green Assays in human, mouse, rat MGST3
      QuantiFast Probe-based Assays in human, mouse, rat MGST3

    Additional mRNA sequence: 

    AF026977.1 AK094471.1 AK223012.1 AK312103.1 BC000505.2 BC003034.2 BC005964.1 BX537737.1 
    CR450359.1 

    17 DOTS entries:

    DT.95154903  DT.75153859  DT.75102318  DT.99933683  DT.453552  DT.91770320  DT.100772862  DT.40121738 
    DT.95154913  DT.91770329  DT.91770337  DT.92325950  DT.100759869  DT.121391841  DT.65287149  DT.91770335 
    DT.121391833 

    Selected AceView cDNA sequences (see all 569):

    CR621489 BM856131 C04037 AW593644 BX113433 AI282609 AI301024 AI277275 
    BF434310 W46485 BX420074 AA354180 BM313199 BM662180 AA033729 AA603767 
    AA609721 BM797525 BM693410 H97313 CR607567 AA736501 AI591182 BM142619 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MGST3 (see all 12)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c · 12d
    SP1:                    -     -     -     -                 -     -                 -           -     -                                       
    SP2:                    -     -     -     -                 -     -                 -           -     -     -                                 
    SP3:                          -     -     -                 -     -                 -           -     -                                       
    SP4:                                                        -     -     -           -           -     -                                       
    SP5:                    -     -     -                       -     -                 -           -     -                                       


    ECgene alternative splicing isoforms for MGST3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    MGST3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACAGCACGG
    MGST3 Expression
    About this image


    MGST3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Adipose (Muscoskeletal System)    fully expand to see all 2 entries
             Body Subcutaneous White Adipose
     
     Epithelial Cells
             Fetal Matrix Cells Hair Follicle
     
     Hair (Integumentary System)
             Fetal Matrix Cells Hair Follicle
    MGST3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MGST3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.191734

    UniProtKB/Swiss-Prot: MGST3_HUMAN, O14880
    Tissue specificity: Predominantly expressed in heart, skeletal muscle, and adrenal cortex. Also found in brain,
    placenta, liver, kidney, pancreas, thyroid, testis and ovary. Almost absent in lung, thymus and peripheral blood
    leukocytes

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MGST3: 
              Oxidative Stress in human mouse rat
              Drug Metabolism: Phase II Enzymes in human mouse rat
              Drug Metabolism in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for MGST3
    OriGene qSTAR qPCR primer pairs in human, mouse for MGST3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MGST3
    QuantiTect SYBR Green Assays in human, mouse, rat MGST3
    QuantiFast Probe-based Assays in human, mouse, rat MGST3
    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MGST3 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mgst31 , 5 microsomal glutathione S-transferase 31, 5 83.77(n)1
    86.18(a)1
      1 (74.76 cM)5
    664471  NM_025569.11  NP_079845.11 
     1673719665 
    chicken
    (Gallus gallus)
    Aves MGST31 microsomal glutathione S-transferase 3 74.29(n)
    80(a)
      424404  NM_001277533.1  NP_001264462.1 
    lizard
    (Anolis carolinensis)
    Reptilia MGST36
    microsomal glutathione S-transferase 3
    78(a)
    1 ↔ 1
    GL343405.1(183574-205426)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.115252 Xenopus laevis transcribed sequence with moderate similarity more 75.06(n)    CF519859.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mgst31 microsomal glutathione S-transferase 3 60.43(n)
    64.75(a)
      406736  NM_213427.1  NP_998592.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G658201 AT1G65820 53.02(n)
    42.52(a)
      842893  NM_105255.2  NP_176758.1 
    rice
    (Oryza sativa)
    Liliopsida Os03g07090001 Os03g0709000 53.12(n)
    45.31(a)
      4333870  NM_001057577.1  NP_001051042.1 


    ENSEMBL Gene Tree for MGST3 (if available)
    TreeFam Gene Tree for MGST3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MGST3 gene
    1 SIMAP similar gene for MGST3 using alignment to 3 protein entries:     MGST3_HUMAN (see all proteins):
    MGST2

    Find genes that share paralogs with MGST3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MGST3 (see all 555)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1919443761,2
    --165598119(+) CCTGGC/TTCCTT 1 -- us2k10--------
    rs1163107691,2
    C,F--165598177(+) TGCCTC/TTGGAA 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1156571861,2
    C,F--165598239(+) ACTTCC/GCACCT 1 -- us2k11Minor allele frequency- G:0.02WA 118
    rs23487331,2
    C,F,A,H--165598262(+) CAAAAC/TATATT 1 -- us2k121Minor allele frequency- T:0.19NS EA NA WA CSA 1216
    rs1413681651,2
    --165598384(+) AATGAC/TATCCA 1 -- us2k10--------
    rs1452842511,2
    C--165598419(+) AACTCC/TCTTCC 1 -- us2k10--------
    rs1136629121,2
    C--165598436(+) GCATCTTA/-TTGAC 1 -- us2k11Minor allele frequency- -:0.50CSA 2
    rs1840659531,2
    C--165598436(+) GCATCC/TTATTG 1 -- us2k10--------
    rs1476338061,2
    --165598529(+) CAAGAC/TTGTAC 1 -- us2k10--------
    rs1491159671,2
    --165598612(+) ATGCAC/GTGATT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for MGST3 (165600098 - 165631033 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for MGST3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv28160CNV Loss19812545

    Human Gene Mutation Database (HGMD): MGST3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MGST3
    DNA2.0 Custom Variant and Variant Library Synthesis for MGST3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604564    OMIM disorders: --


    Find genes that share disorders with MGST3           About GenesLikeMe

    Genetic Association Database (GAD): MGST3
    Human Genome Epidemiology (HuGE) Navigator: MGST3 (5 documents)

    Export disorders for MGST3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MGST3 gene, integrated from 10 sources (see all 35):
    (articles sorted by number of sources associating them with MGST3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of a novel microsomal enzyme with glutathione-dependent transferase and peroxidase activities. (PubMed id 9278457)1, 2, 3, 9 Jakobsson P.-J.... Ford-Hutchinson A.W. (J. Biol. Chem. 1997)
    2. Evaluation of the microsomal glutathione S-transferase 3 (MGST3) locus on 1q23 as a Type 2 diabetes susceptibility gene in Pima Indians. (PubMed id 12898215)1, 4, 9 Thameem F....Prochazka M. (Hum. Genet. 2003)
    3. Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease. (PubMed id 21116278)1, 4 Furney S.J.... . (Mol. Psychiatry 2011)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PubMed id 19343046)1, 4 Saito A....Kamatani N. (J. Hum. Genet. 2009)
    6. Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study. (PubMed id 19536175)1, 4 Ehret G.B....Chakravarti A. (Eur. J. Hum. Genet. 2009)
    7. Pre-B-cell leukemia homeobox 1 (PBX1) shows functional and possible genetic association with bone mineral density variation. (PubMed id 19064610)1, 4 Cheung C.L....Kung A.W. (Hum. Mol. Genet. 2009)
    8. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4259 HGNC: 7064 AceView: MGST3 Ensembl:ENSG00000143198 euGenes: HUgn4259
    ECgene: MGST3 Kegg: 4259 H-InvDB: MGST3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MGST3 Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/mgst3/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MGST3 gene:
    Search GeneIP for patents involving MGST3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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