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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MGST2 Gene

protein-coding   GIFtS: 62
GCID: GC04P140586

microsomal glutathione S-transferase 2
 Explore 5 diseases affiliated with
MGST2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MGST2    

Aliases
for MGST2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Microsomal Glutathione S-Transferase 21 2
GST22 3 5
MGST-II1 2
Microsomal GST-22 3
Microsomal GST-II2 3
EC 2.5.1.183

External Ids:    HGNC: 70631   Entrez Gene: 42582   Ensembl: ENSG000000858717   OMIM: 6017335   UniProtKB: Q997353   

Export aliases for MGST2 gene to outside databases

Previous GC identifers: GC04P141492 GC04P140886 GC04P141053 GC04P141164 GC04P140944 GC04P136315


Summaries
for MGST2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for MGST2:
The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human
proteins, several of which are involved in the production of leukotrienes and prostaglandin E, important mediators of
inflammation. This gene encodes a protein which catalyzes the conjugation of leukotriene A4 and reduced glutathione to
produce leukotriene C4. Alternatively spliced transcript variants encoding different isoforms have been identified in
this gene. (provided by RefSeq, Feb 2011)

UniProtKB/Swiss-Prot: MGST2_HUMAN, Q99735
Function: Can catalyze the production of LTC4 from LTA4 and reduced glutathione. Can catalyze the conjugation of
1-chloro-2,4-dinitrobenzene with reduced glutathione

Gene Wiki entry for MGST2


Genomic Views
for MGST2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_016354.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MGST2 gene promoter:
         AML1a   Brachyury   ATF-2   MEF-2   FOXD1   Evi-1   GATA-2   MEF-2A   HOXA5   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MGST2 promoter sequence
   Search SABiosciences Chromatin IP Primers for MGST2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MGST2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q28.3   Ensembl cytogenetic band:  4q31.1   HGNC cytogenetic band: 4q28.3

MGST2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MGST2 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P140586:  view genomic region     (about GC identifiers)

Start:
 140,586,922 bp from pter      End:
 140,661,899 bp from pter
Size:
 74,978 bases      Orientation:
 plus strand

Proteins
for MGST2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MGST2_HUMAN, Q99735 (See protein sequence)
Recommended Name: Microsomal glutathione S-transferase 2  
Size: 147 amino acids; 16621 Da
Subunit: Homotrimer
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Microsome membrane;
Multi-pass membrane protein (Potential)
Secondary accessions: D6RBB5 Q7Z5B8
Alternative splicing: 2 isoforms:  Q99735-1   Q99735-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MGST2: NX_Q99735

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q99735

    • MGST2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (4 alternative transcripts): 
    NP_001191295.1  NP_001191296.1  NP_001191297.1  NP_002404.1  

    ENSEMBL proteins: 
     ENSP00000265498   ENSP00000424278   ENSP00000423008  
    Reactome Protein details: Q99735
    Human Recombinant Protein Products: 
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    Novus Biologicals MGST2 Protein
    Novus Biologicals MGST2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for MGST2

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005635nuclear envelope IBA--
    GO:0005737cytoplasm ----
    GO:0005783endoplasmic reticulum IBA--
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0005792microsome ----


    MGST2 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for MGST2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MGST2 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR001446 5_LipOase_AP
     IPR018295 FLAP/GST2/LTC4S_CS
     IPR023352 MAPEG-like_dom
     IPR001129 Membr-assoc_MAPEG

    Graphical View of Domain Structure for InterPro Entry Q99735

    ProtoNet protein and cluster: Q99735

    1 Blocks protein family: IPB001129 Membrane-associated proteins in eicosanoid and glutathione metabolism (MAPEG)

    UniProtKB/Swiss-Prot: MGST2_HUMAN, Q99735
    Similarity: Belongs to the MAPEG family


    Function
    for MGST2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: MGST2_HUMAN, Q99735
    Function: Can catalyze the production of LTC4 from LTA4 and reduced glutathione. Can catalyze the conjugation of
    1-chloro-2,4-dinitrobenzene with reduced glutathione
    Catalytic activity: RX + glutathione = HX + R-S-glutathione

         Genatlas biochemistry entry for MGST2:
    microsomal glutathione-S-transferase 2,expressed in liver,spleen,heart,skeletal muscle,involved in leukotriene
    biosynthesis,microsomal,GST superfamily

    Enzyme Number (IUBMB): EC 2.5.1.181

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MGST2
    8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate MGST2 (see all 12):
    hsa-miR-3688-3p hsa-miR-1271 hsa-miR-491-3p hsa-miR-103a hsa-miR-3142 hsa-miR-885-3p hsa-miR-182 hsa-miR-617
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene shRNA RFP: MGST2
    OriGene siRNA: MGST2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MGST2

    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004364glutathione transferase activity IDA8703034
    GO:0004464leukotriene-C4 synthase activity IDA9092565
    GO:0004602glutathione peroxidase activity IBA--
    GO:0008047enzyme activator activity IEA--


    MGST2 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for MGST2:
     Decreased viability of wild-ty  Upregulation of Wnt/beta-caten 


    Pathways & Interactions
    for MGST2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Glutathione metabolism
    		Glutathione metabolism1.00
    		glutathione-mediated detoxification I0.53
    		Glutathione metabolism0.92
    		Glutathione conjugation0.50
    		Glutathione metabolism0.70
    2Biological oxidations
    		Biological oxidations1.00
    		metapathway biotransformation0.41
    		Phase II conjugation0.52
    3Drug metabolism - cytochrome P450
    		Drug metabolism - cytochrome P4501.00
    		Metabolism of xenobiotics by cytochrome P4500.73
    4Arachidonic acid metabolism
    		HETE and HPETE biosynthesis and metabolism0.39
    		HETE and HPETE biosynthesis and metabolism0.39
    5Metabolism
    		Metabolism1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 EMD Millipore Pathways for MGST2
        HETE and HPETE biosynthesis and metabolism
    Glutathione metabolism


    2 GeneGo (Thomson Reuters) Pathways for MGST2
        HETE and HPETE biosynthesis and metabolism
    Glutathione metabolism

    2 BioSystems Pathways for MGST2 
        glutathione-mediated detoxification I
    metapathway biotransformation

    4        Reactome Pathways for MGST2
        Metabolism
    Biological oxidations
    Glutathione conjugation
    Phase II conjugation

    1 PharmGKB Pathway for MGST2
        Busulfan Pathway, Pharmacodynamics

    3         Kegg Pathways  (Kegg details for MGST2):
        Glutathione metabolism
    Metabolism of xenobiotics by cytochrome P450
    Drug metabolism - cytochrome P450


    MGST2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MGST2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/62 Interacting proteins for MGST2 (Q997353 ENSP000002654984) via UniProtKB, MINT, STRING, and/or I2D (see all 62)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HDHD2Q9H0R43, ENSP000003006054I2D: score=1 STRING: ENSP00000300605
    SKOR2Q2VWA43I2D: score=1 
    ADH7ENSP000002096654STRING: ENSP00000209665
    ALDH3A1ENSP000002257404STRING: ENSP00000225740
    CYP1A1ENSP000003690504STRING: ENSP00000369050
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006750glutathione biosynthetic process IDA8703034
    GO:0006805xenobiotic metabolic process TAS--
    GO:0010243response to organic nitrogen ----
    GO:0019370leukotriene biosynthetic process IDA8703034
    GO:0032496response to lipopolysaccharide ----


    MGST2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for MGST2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MGST2 for compounds           About GeneDecksing

    EMD Millipore small molecules for MGST2:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MGST2

    10/12 HMDB Compounds for MGST2 (see all 12)    About this table
    CompoundSynonyms CAS #PubMed Ids
    2-Hydroxyestrone-1-S-glutathione2,3-dihydroxy-1,3,5[10]-estratriene-17-one-1-S-glutathione;2-hydroxyestrone-1-S-glutathione ----
    2-Hydroxyestrone-4-S-glutathione2,3-dihydroxy-1,3,5[10]-estratriene-17-one-4-S-glutathione ----
    4-Hydroxyestrone-2-S-glutathione3,4-dihydroxy-1,3,5[10]-estratriene-17-one-2-S-glutathione ----
    Adrenochromeadrenochrome oxidised;adrenochrome O-quinone;N-methyl-5,6-dioxo-2,3,5,6-tetrahydro-3-hydroxyindole;N-methyl-5,6-dioxo-2,3,5,6-tetrahydro-3-indolol;AdChr 54-06-8--
    Estrone-2,3-quinonecatecholestrogen quinone 40551-33-5--
    Estrone-3,4-quinonecatecholestrogen quinone 633-34-1--
    Glutathione5-L-Glutamyl-L-cysteinylglycine (see all 32)70-18-8--
    Hydrochloric acidHydrogen chloride anhydrous [UN1050] [Poison gas] (see all 16)7647-01-0--
    Noradrenochromenoradrenochrome O-quinone;noradrenochrome oxidised;5,6-dioxo-2,3,5,6-tetrahydro-3-hydroxyindole;5,6-dioxo-2,3,5,6-tetrahydro-3-indolol;AdChr 490-89-1--
    S-(PGJ2)-glutathioneGSPGJ2;9-(S-glutathionyl)-prostaglandin J(,2) ----

    1 DrugBank Compound for MGST2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Glutathione5-L-Glutamyl-L-cysteinylglycine (see all 5)70-18-8target--17632548

    2 Novoseek chemical compound relationships for MGST2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ltc4 76.4 5 11322876 (4), 9230064 (1)
    gsts 65.1 2 15607001 (1), 9230064 (1)

    Search CenterWatch for drugs/clinical trials and news about MGST2 

    Transcripts
    for MGST2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MGST2 gene (4 alternative transcripts): 
    NM_001204366.1  NM_001204367.1  NM_001204368.1  NM_002413.4  

    Unigene Cluster for MGST2:

    Microsomal glutathione S-transferase 2
    Hs.81874  [show with all ESTs]
    Unigene Representative Sequence: BX538128
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000265498(uc003ihy.3 uc021xse.1) ENST00000506797 ENST00000515137(uc021xsf.1 uc010ioi.1)
    ENST00000502587 ENST00000503816 ENST00000515067

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    hsa-miR-3688-3p hsa-miR-1271 hsa-miR-491-3p hsa-miR-103a hsa-miR-3142 hsa-miR-885-3p hsa-miR-182 hsa-miR-617
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    Additional cDNA sequence: 

    AK130948.1 AK307231.1 BC025416.1 BX538128.1 CR407640.1 U77604.1 

    8 DOTS entries:

    DT.453234  DT.92431846  DT.92431849  DT.100815111  DT.121236341  DT.100740204  DT.121236331  DT.97820548 

    24/178 AceView cDNA sequences (see all 178):

    BE791999 BG109770 CB991077 W93965 F30810 BM838445 AA122237 W93999 
    BM856400 BI063204 BI062653 BG621659 AU133068 BE909913 CA942823 CR407640 
    BI062563 AA452952 BI063000 BI063059 BI061711 AA443448 AA724376 AI421427 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for MGST2 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d
    SP1:                                                  -                                             
    SP2:                                -                 -     -                                       
    SP3:                                                  -     -     -                                 
    SP4:                                -                 -     -     -                                 
    SP5:                                -     -     -     -     -                                       


    ECgene alternative splicing isoforms for MGST2

    Expression
    for MGST2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MGST2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AAGGTAATAT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    MGST2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    SomiteLumbar Vertebral BodySomite
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 4 LifeMap Cells 
    NameCategory
    Definitive endoderm-like cells (Generation of mesend...)
    Mesendoderm-like cells (Generation of mesend...)
    Definitive endoderm-like cells (A scalable, suspensi...)
    Definitive Endoderm (Generation of beta c...)

    See MGST2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MGST2

    SOURCE GeneReport for Unigene cluster: Hs.81874

    UniProtKB/Swiss-Prot: MGST2_HUMAN, Q99735
    Tissue specificity: Liver, spleen, skeletal muscle, heart, adrenals, pancreas, prostate, testis, fetal liver, and fetal
    spleen. Very low expression in lung, brain, placenta and bone marrow

        SABiosciences Expression via Pathway-Focused PCR Arrays including MGST2: 
              Drug Metabolism: Phase II Enzymes in human mouse rat
              Drug Metabolism in human mouse rat

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    In Situ
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    Orthologs
    for MGST2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for MGST2 gene from 2/10 species (see all 10)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves MGST21 microsomal glutathione S-transferase 2 67.35(n)
    63.95(a)    		   770916  XM_001234229.2  XP_001234230.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii mgst21 microsomal glutathione S-transferase 2 56.15(n)
    53.08(a)    		   723997  NM_001045302.1  NP_001038767.1 


    ENSEMBL Gene Tree for MGST2 (if available)
    TreeFam Gene Tree for MGST2 (if available) 

    Paralogs
    for MGST2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MGST2 gene
    ALOX5AP2  LTC4S2  
    3 SIMAP similar genes for MGST2 using alignment to 1 protein entry:     MGST2_HUMAN:
    LTC4S    MGST3    ALOX5AP

    MGST2 for paralogs           About GeneDecksing



    Genomic Variants
    for MGST2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Human Gene Mutation Database (HGMD): MGST2
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MGST2
    DNA2.0 Custom Variant and Variant Library Synthesis for MGST2

    Disorders / Diseases
    for MGST2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MGST2 for disorders           About GeneDecksing

    OMIM gene information: 601733    OMIM disorders: --

    5 diseases for MGST2:    About MalaCards
    chronic myeloid leukemia    myeloid leukemia    psoriasis    leukemia
    prostatitis

    2 Novoseek disease relationships for MGST2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    psoriasis 40.2 9 16773312 (4), 16498398 (3)
    asthma 16 1 10436863 (1)

    Human Genome Epidemiology (HuGE) Navigator: MGST2 (5 documents)

    Export disorders for MGST2 gene to outside databases

    Publications
    for MGST2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MGST2 gene, integrated from 9 sources (see all 24):
    (articles sorted by number of sources associating them with MGST2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of a novel human microsomal glutathione S-transferase with leukotriene C4 synthase activity and significant sequence identity to 5-lipoxygenase-activating protein and leukotriene C4 synthase. (PubMed id 8703034)1, 2, 3 Jakobsson P.-J.... Ford-Hutchinson A.W. (1996)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Systematic evaluation of association between the microsomal glutathione S-transferase 2 common variation and psoriasis vulgaris in Chinese population. (PubMed id 16773312)1, 9 Yang S....Liu J.J. (2006)
    4. A novel MGST2 non-synonymous mutation in a Chinese pedigree with psoriasis vulgaris. (PubMed id 16498398)1, 9 Yan K.L....Liu J.J. (2006)
    5. Human umbilical vein endothelial cells generate leukotriene C4 via microsomal glutathione S-transferase type 2 and express the CysLT(1) receptor. (PubMed id 11322876)1, 9 Sjostrom M....Haeggstrom J.Z. (2001)
    6. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    7. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    8. Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PubMed id 19343046)1 Saito A....Kamatani N. (2009)
    9. Crystal structure of a human membrane protein involved in cysteinyl leukotriene biosynthesis. (PubMed id 17632548)7 Ago H....Miyano M. (2007)
    10. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)

    External Searches for MGST2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing MGST2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4258 HGNC: 7063 AceView: MGST2 Ensembl:ENSG00000085871 euGenes: HUgn4258
    ECgene: MGST2 Kegg: 4258 H-InvDB: MGST2

    Other Databases showing MGST2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing MGST2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MGST2 Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/mgst2/

    Intellectual Property
    for MGST2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MGST2 gene:
    Search GeneIP for patents involving MGST2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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