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Aliases for MGST2 Gene

Aliases for MGST2 Gene

  • Microsomal Glutathione S-Transferase 2 2 3 5
  • Microsomal GST-II 3 4
  • Microsomal GST-2 3 4
  • GST2 3 4
  • EC 2.5.1.18 4
  • MGST-II 3

External Ids for MGST2 Gene

Previous GeneCards Identifiers for MGST2 Gene

  • GC04P141492
  • GC04P140886
  • GC04P141053
  • GC04P141164
  • GC04P140944
  • GC04P140586
  • GC04P136315

Summaries for MGST2 Gene

Entrez Gene Summary for MGST2 Gene

  • The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, several of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. This gene encodes a protein which catalyzes the conjugation of leukotriene A4 and reduced glutathione to produce leukotriene C4. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Feb 2011]

GeneCards Summary for MGST2 Gene

MGST2 (Microsomal Glutathione S-Transferase 2) is a Protein Coding gene. Among its related pathways are Cytochrome P450 - arranged by substrate type and Drug metabolism - cytochrome P450. GO annotations related to this gene include enzyme activator activity and glutathione peroxidase activity. An important paralog of this gene is LTC4S.

UniProtKB/Swiss-Prot for MGST2 Gene

  • Can catalyze the production of LTC4 from LTA4 and reduced glutathione. Can catalyze the conjugation of 1-chloro-2,4-dinitrobenzene with reduced glutathione.

Gene Wiki entry for MGST2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MGST2 Gene

Genomics for MGST2 Gene

Regulatory Elements for MGST2 Gene

Enhancers for MGST2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04F139656 1.3 FANTOM5 Ensembl ENCODE 12.8 -6.6 -6595 5.3 ATF1 MLX ARID4B ZNF143 FOS ZNF263 SP5 MXD4 REST PPARG MGST2 LOC101927490
GH04F139663 1.1 Ensembl ENCODE 12.3 +1.3 1338 7.4 PKNOX1 ARNT CREB3L1 MLX ARID4B SIN3A DMAP1 YY1 SP5 ZHX2 MGST2 GC04P139684
GH04F139674 1 Ensembl ENCODE 5.4 +9.5 9533 1.4 GATAD2A ZNF680 TEAD1 HLF FOXA3 CEBPB CEBPG CEBPA IKZF1 SPI1 MGST2 GC04P139684
GH04F139651 1.3 Ensembl ENCODE 0.4 -14.2 -14155 0.8 CTCF IRF2 TAL1 ZNF2 RAD21 FOXK2 ZNF366 NCOR1 SCRT2 ZNF143 LOC101927490 MGST2
GH04F139676 1 Ensembl ENCODE 0.4 +10.7 10741 0.3 GC04P139684 MGST2
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MGST2 on UCSC Golden Path with GeneCards custom track

Promoters for MGST2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001250357 732 2201 PKNOX1 ARNT CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF48 YY1 GATA2

Genomic Location for MGST2 Gene

Chromosome:
4
Start:
139,665,768 bp from pter
End:
139,740,745 bp from pter
Size:
74,978 bases
Orientation:
Plus strand

Genomic View for MGST2 Gene

Genes around MGST2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MGST2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MGST2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MGST2 Gene

Proteins for MGST2 Gene

  • Protein details for MGST2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99735-MGST2_HUMAN
    Recommended name:
    Microsomal glutathione S-transferase 2
    Protein Accession:
    Q99735
    Secondary Accessions:
    • D6RBB5
    • Q7Z5B8

    Protein attributes for MGST2 Gene

    Size:
    147 amino acids
    Molecular mass:
    16621 Da
    Quaternary structure:
    • Homotrimer.

    Alternative splice isoforms for MGST2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MGST2 Gene

Post-translational modifications for MGST2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MGST2 Gene

Domains & Families for MGST2 Gene

Gene Families for MGST2 Gene

Suggested Antigen Peptide Sequences for MGST2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q99735

UniProtKB/Swiss-Prot:

MGST2_HUMAN :
  • Belongs to the MAPEG family.
Family:
  • Belongs to the MAPEG family.
genes like me logo Genes that share domains with MGST2: view

Function for MGST2 Gene

Molecular function for MGST2 Gene

GENATLAS Biochemistry:
microsomal glutathione-S-transferase 2,expressed in liver,spleen,heart,skeletal muscle,involved in leukotriene biosynthesis,microsomal,GST superfamily
UniProtKB/Swiss-Prot CatalyticActivity:
RX + glutathione = HX + R-S-glutathione.
UniProtKB/Swiss-Prot Function:
Can catalyze the production of LTC4 from LTA4 and reduced glutathione. Can catalyze the conjugation of 1-chloro-2,4-dinitrobenzene with reduced glutathione.

Enzyme Numbers (IUBMB) for MGST2 Gene

Gene Ontology (GO) - Molecular Function for MGST2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004364 glutathione transferase activity TAS --
GO:0004464 leukotriene-C4 synthase activity IDA 8703034
GO:0004602 glutathione peroxidase activity IEA,IBA --
GO:0008047 enzyme activator activity IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with MGST2: view
genes like me logo Genes that share phenotypes with MGST2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for MGST2

miRNA for MGST2 Gene

miRTarBase miRNAs that target MGST2

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MGST2 Gene

Localization for MGST2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MGST2 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein. Microsome membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MGST2 Gene COMPARTMENTS Subcellular localization image for MGST2 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 5
extracellular 3
nucleus 2
cytosol 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for MGST2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005635 nuclear envelope IBA --
GO:0005737 cytoplasm IEA --
GO:0005783 endoplasmic reticulum IEA,IBA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0005886 plasma membrane IDA 9092565
genes like me logo Genes that share ontologies with MGST2: view

Pathways & Interactions for MGST2 Gene

genes like me logo Genes that share pathways with MGST2: view

Gene Ontology (GO) - Biological Process for MGST2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006691 leukotriene metabolic process IEA --
GO:0006750 glutathione biosynthetic process IDA 8703034
GO:0006805 xenobiotic metabolic process TAS --
GO:0010243 response to organonitrogen compound IEA --
GO:0019370 leukotriene biosynthetic process IEA,IDA 8703034
genes like me logo Genes that share ontologies with MGST2: view

No data available for SIGNOR curated interactions for MGST2 Gene

Drugs & Compounds for MGST2 Gene

(5) Drugs for MGST2 Gene - From: DrugBank, FDA Approved Drugs, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glutathione Approved Nutra Target 0
Busulfan Approved, Investigational Pharma Enzyme, substrate 540
Busulfex Approved February 1999 Pharma 0
Water Approved Pharma 0
Trichloroethylene Pharma 5

(41) Additional Compounds for MGST2 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(1R)-Glutathionyl-(2R)-hydroxy-1,2-dihydronaphthalene
(1R)-Hydroxy-(2R)-glutathionyl-1,2-dihydronaphthalene
(1S)-Hydroxy-(2S)-glutathionyl-1,2-dihydronaphthalene
(1S,2R)-Naphthalene 1,2-oxide
1,1-Dichloroethylene epoxide
genes like me logo Genes that share compounds with MGST2: view

Transcripts for MGST2 Gene

Unigene Clusters for MGST2 Gene

Microsomal glutathione S-transferase 2:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MGST2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d
SP1: -
SP2: - - -
SP3: - - -
SP4: - - - -
SP5: - - - - -
SP6: -

Relevant External Links for MGST2 Gene

GeneLoc Exon Structure for
MGST2
ECgene alternative splicing isoforms for
MGST2

Expression for MGST2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MGST2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MGST2 Gene

This gene is overexpressed in Nasal epithelium (15.3), Liver (7.2), and Pancreas (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MGST2 Gene



Protein tissue co-expression partners for MGST2 Gene

NURSA nuclear receptor signaling pathways regulating expression of MGST2 Gene:

MGST2

SOURCE GeneReport for Unigene cluster for MGST2 Gene:

Hs.81874

mRNA Expression by UniProt/SwissProt for MGST2 Gene:

Q99735-MGST2_HUMAN
Tissue specificity: Liver, spleen, skeletal muscle, heart, adrenals, pancreas, prostate, testis, fetal liver, and fetal spleen. Very low expression in lung, brain, placenta and bone marrow.
genes like me logo Genes that share expression patterns with MGST2: view

Primer Products

No data available for mRNA differential expression in normal tissues for MGST2 Gene

Orthologs for MGST2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MGST2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MGST2 34 35
  • 99.55 (n)
cow
(Bos Taurus)
Mammalia MGST2 34 35
  • 88.28 (n)
dog
(Canis familiaris)
Mammalia MGST2 34 35
  • 86.58 (n)
rat
(Rattus norvegicus)
Mammalia Mgst2 34
  • 81.63 (n)
mouse
(Mus musculus)
Mammalia Mgst2 34 16 35
  • 80.27 (n)
oppossum
(Monodelphis domestica)
Mammalia MGST2 35
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MGST2 35
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves MGST2 34 35
  • 67.35 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101731146 34
  • 59.54 (n)
zebrafish
(Danio rerio)
Actinopterygii mgst2 34 35
  • 56.15 (n)
Species where no ortholog for MGST2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MGST2 Gene

ENSEMBL:
Gene Tree for MGST2 (if available)
TreeFam:
Gene Tree for MGST2 (if available)

Paralogs for MGST2 Gene

Paralogs for MGST2 Gene

(3) SIMAP similar genes for MGST2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MGST2: view

Variants for MGST2 Gene

Sequence variations from dbSNP and Humsavar for MGST2 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1000222 -- 139,666,831(-) GTCTA(C/T)GGCTT intron-variant
rs10005805 -- 139,744,764(+) TTCAC(A/G)GAAAA intron-variant
rs10018096 -- 139,713,475(+) agaca(A/G)aaaaa intron-variant
rs10034474 -- 139,711,329(+) ttgca(C/T)gagtg intron-variant
rs10049940 -- 139,752,238(+) ACCTT(A/G)CAGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MGST2 Gene

Variant ID Type Subtype PubMed ID
dgv1533e212 CNV loss 25503493
esv3569728 CNV loss 25503493
esv3602439 CNV gain 21293372
esv3602440 CNV gain 21293372
nsv472268 CNV novel sequence insertion 20440878
nsv525242 CNV loss 19592680
nsv830086 CNV gain 17160897
nsv964099 CNV duplication 23825009

Variation tolerance for MGST2 Gene

Residual Variation Intolerance Score: 63.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.02; 37.26% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MGST2 Gene

Human Gene Mutation Database (HGMD)
MGST2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MGST2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MGST2 Gene

Disorders for MGST2 Gene

Relevant External Links for MGST2

Genetic Association Database (GAD)
MGST2
Human Genome Epidemiology (HuGE) Navigator
MGST2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MGST2

No disorders were found for MGST2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MGST2 Gene

Publications for MGST2 Gene

  1. A novel MGST2 non-synonymous mutation in a Chinese pedigree with psoriasis vulgaris. (PMID: 16498398) Yan K.L. … Liu J.J. (J. Invest. Dermatol. 2006) 3 22 46 64
  2. Systematic evaluation of association between the microsomal glutathione S-transferase 2 common variation and psoriasis vulgaris in Chinese population. (PMID: 16773312) Yang S. … Liu J.J. (Arch. Dermatol. Res. 2006) 3 22 46 64
  3. Identification and characterization of a novel human microsomal glutathione S-transferase with leukotriene C4 synthase activity and significant sequence identity to 5-lipoxygenase-activating protein and leukotriene C4 synthase. (PMID: 8703034) Jakobsson P.-J. … Ford-Hutchinson A.W. (J. Biol. Chem. 1996) 2 3 4 64
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  5. Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PMID: 19343046) Saito A. … Kamatani N. (J. Hum. Genet. 2009) 3 46 64

Products for MGST2 Gene

Sources for MGST2 Gene

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