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MGST2 Gene

protein-coding   GIFtS: 65
GCID: GC04P140586

Microsomal Glutathione S-Transferase 2

  Search for MGST2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Microsomal Glutathione S-Transferase 21 2
GST22 3 5
Microsomal GST-22 3
Microsomal GST-II2 3
MGST-II2
EC 2.5.1.183

External Ids:    HGNC: 70631   Entrez Gene: 42582   Ensembl: ENSG000000858717   OMIM: 6017335   UniProtKB: Q997353   

Export aliases for MGST2 gene to outside databases

Previous GC identifers: GC04P141492 GC04P140886 GC04P141053 GC04P141164 GC04P140944 GC04P136315


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MGST2 Gene:
The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human
proteins, several of which are involved in the production of leukotrienes and prostaglandin E, important
mediators of inflammation. This gene encodes a protein which catalyzes the conjugation of leukotriene A4 and
reduced glutathione to produce leukotriene C4. Alternatively spliced transcript variants encoding different
isoforms have been identified in this gene. (provided by RefSeq, Feb 2011)

GeneCards Summary for MGST2 Gene:
MGST2 (microsomal glutathione S-transferase 2) is a protein-coding gene. GO annotations related to this gene include enzyme activator activity and glutathione peroxidase activity. An important paralog of this gene is LTC4S.

UniProtKB/Swiss-Prot: MGST2_HUMAN, Q99735
Function: Can catalyze the production of LTC4 from LTA4 and reduced glutathione. Can catalyze the conjugation of
1-chloro-2,4-dinitrobenzene with reduced glutathione

Gene Wiki entry for MGST2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NT_016354.20  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MGST2 gene promoter:
         AML1a   Brachyury   ATF-2   MEF-2   FOXD1   Evi-1   GATA-2   MEF-2A   HOXA5   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMGST2 promoter sequence
   Search Chromatin IP Primers for MGST2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MGST2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q28.3   Ensembl cytogenetic band:  4q31.1   HGNC cytogenetic band: 4q28.3

MGST2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MGST2 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P140586:  view genomic region     (about GC identifiers)

Start:
140,586,922 bp from pter      End:
140,661,899 bp from pter
Size:
74,978 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MGST2_HUMAN, Q99735 (See protein sequence)
Recommended Name: Microsomal glutathione S-transferase 2  
Size: 147 amino acids; 16621 Da
Subunit: Homotrimer
Secondary accessions: D6RBB5 Q7Z5B8
Alternative splicing: 2 isoforms:  Q99735-1   Q99735-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MGST2: NX_Q99735

Explore proteomics data for MGST2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MGST2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001191295.1  NP_001191296.1  NP_001191297.1  NP_002404.1  

    ENSEMBL proteins: 
     ENSP00000265498   ENSP00000424278   ENSP00000423008  
    Reactome Protein details: Q99735

    MGST2 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for MGST2
    OriGene Custom MassSpec
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    Novus Biologicals MGST2 Protein
    Novus Biologicals MGST2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MGST2

     
    Search eBioscience for Proteins for MGST2 

    MGST2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    LSBio Antibodies in human, mouse, rat for MGST2

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    Cloud-Clone Corp. ELISAs for MGST2
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    Search eBioscience for ELISAs for MGST2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    MGST: Glutathione S-transferases / Microsomal

    4 InterPro protein domains:
     IPR001446 5_LipOase_AP
     IPR018295 FLAP/GST2/LTC4S_CS
     IPR023352 MAPEG-like_dom
     IPR001129 Membr-assoc_MAPEG

    Graphical View of Domain Structure for InterPro Entry Q99735

    ProtoNet protein and cluster: Q99735

    1 Blocks protein domain: IPB001129 Membrane-associated proteins in eicosanoid and glutathione metabolism (MAPEG)

    UniProtKB/Swiss-Prot: MGST2_HUMAN, Q99735
    Similarity: Belongs to the MAPEG family


    Find genes that share domains with MGST2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MGST2_HUMAN, Q99735
    Function: Can catalyze the production of LTC4 from LTA4 and reduced glutathione. Can catalyze the conjugation of
    1-chloro-2,4-dinitrobenzene with reduced glutathione
    Catalytic activity: RX + glutathione = HX + R-S-glutathione

         Genatlas biochemistry entry for MGST2:
    microsomal glutathione-S-transferase 2,expressed in liver,spleen,heart,skeletal muscle,involved in leukotriene
    biosynthesis,microsomal,GST superfamily

         Enzyme Number (IUBMB): EC 2.5.1.181

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004364glutathione transferase activity IDA8703034
    GO:0004464leukotriene-C4 synthase activity IDA8703034
    GO:0004602glutathione peroxidase activity IBA--
    GO:0008047enzyme activator activity IEA--
         
    Find genes that share ontologies with MGST2           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for MGST2:
     Decreased viability of wild-ty  Upregulation of Wnt/beta-caten 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MGST2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MGST2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MGST2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MGST2

    miRNA
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    miRTarBase miRNAs that target MGST2:
    hsa-mir-30a-5p (MIRT028440), hsa-mir-155-5p (MIRT020512), hsa-mir-340-3p (MIRT043852)

    Block miRNA regulation of human, mouse, rat MGST2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MGST2 (see all 12):
    hsa-miR-3688-3p hsa-miR-1271 hsa-miR-491-3p hsa-miR-103a hsa-miR-3142 hsa-miR-885-3p hsa-miR-182 hsa-miR-617
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat MGST2

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 4): MGST2 (NM_001204367)
    Browse Sino Biological Human cDNA Clones
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MGST2_HUMAN, Q99735: Endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Microsome membrane;
    Multi-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    plasma membrane5
    extracellular3
    nucleus3
    lysosome1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005635nuclear envelope IBA--
    GO:0005737cytoplasm ----
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0005886plasma membrane IDA9092565
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with MGST2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MGST2 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Glutathione metabolism
    Glutathione metabolism0.65
    Glutathione conjugation0.60
    Glutathione metabolism0.65
    glutathione-mediated detoxification I0.42
    2Biological oxidations
    Biological oxidations0.56
    metapathway biotransformation0.42
    Phase II conjugation0.56
    3Chemical carcinogenesis
    Chemical carcinogenesis0.71
    Drug metabolism - cytochrome P4500.69
    Metabolism of xenobiotics by cytochrome P4500.71
    4Metabolism
    Metabolism0.38
    5Arachidonic acid metabolism
    HETE and HPETE biosynthesis and metabolism0.33


    Find genes that share SuperPaths with MGST2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 GeneGo (Thomson Reuters) Pathways for MGST2
        HETE and HPETE biosynthesis and metabolism
    Glutathione metabolism

    2 BioSystems Pathways for MGST2
        glutathione-mediated detoxification I
    metapathway biotransformation

    1 Reactome Pathway for MGST2
        Glutathione conjugation

    1 PharmGKB Pathway for MGST2
        Busulfan Pathway, Pharmacodynamics

    4 Kegg Pathways  (Kegg details for MGST2):
        Glutathione metabolism
    Metabolism of xenobiotics by cytochrome P450
    Drug metabolism - cytochrome P450
    Chemical carcinogenesis

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MGST2: 
              Drug Metabolism: Phase II Enzymes in human mouse rat
              Drug Metabolism in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for MGST2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MGST2 (Q997353 ENSP000002654984) via UniProtKB, MINT, STRING, and/or I2D (see all 62)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HDHD2Q9H0R43, ENSP000003006054I2D: score=1 STRING: ENSP00000300605
    SKOR2Q2VWA43I2D: score=1 
    ADH7ENSP000002096654STRING: ENSP00000209665
    ALDH3A1ENSP000002257404STRING: ENSP00000225740
    CYP1A1ENSP000003690504STRING: ENSP00000369050
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006750glutathione biosynthetic process IDA8703034
    GO:0006805xenobiotic metabolic process TAS--
    GO:0010243response to organonitrogen compound IEA--
    GO:0019370leukotriene biosynthetic process IDA8703034
    GO:0032496response to lipopolysaccharide IEA--

    Find genes that share ontologies with MGST2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MGST2

    Selected HMDB Compounds for MGST2 (see all 12)    About this table
    CompoundSynonyms CAS #PubMed Ids
    2-Hydroxyestrone-1-S-glutathione2,3-dihydroxy-1,3,5[10]-estratriene-17-one-1-S-glutathione;2-hydroxyestrone-1-S-glutathione ----
    2-Hydroxyestrone-4-S-glutathione2,3-dihydroxy-1,3,5[10]-estratriene-17-one-4-S-glutathione ----
    4-Hydroxyestrone-2-S-glutathione3,4-dihydroxy-1,3,5[10]-estratriene-17-one-2-S-glutathione ----
    Adrenochromeadrenochrome oxidised;adrenochrome O-quinone;N-methyl-5,6-dioxo-2,3,5,6-tetrahydro-3-hydroxyindole;N-methyl-5,6-dioxo-2,3,5,6-tetrahydro-3-indolol;AdChr 54-06-8--
    Estrone-2,3-quinonecatecholestrogen quinone 40551-33-5--
    Estrone-3,4-quinonecatecholestrogen quinone 633-34-1--
    Glutathione5-L-Glutamyl-L-cysteinylglycine (see all 32)70-18-8--
    Hydrochloric acidHydrogen chloride anhydrous [UN1050] [Poison gas] (see all 16)7647-01-0--
    Noradrenochromenoradrenochrome O-quinone;noradrenochrome oxidised;5,6-dioxo-2,3,5,6-tetrahydro-3-hydroxyindole;5,6-dioxo-2,3,5,6-tetrahydro-3-indolol;AdChr 490-89-1--
    S-(PGJ2)-glutathioneGSPGJ2;9-(S-glutathionyl)-prostaglandin J(,2) ----

    2 DrugBank Compounds for MGST2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    BusulfanBusulphan (see all 8)55-98-1enzymesubstrate15779864
    Glutathione5-L-Glutamyl-L-cysteinylglycine (see all 5)70-18-8target--17632548

    2 Novoseek inferred chemical compound relationships for MGST2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ltc4 76.4 5 11322876 (4), 9230064 (1)
    gsts 65.1 2 15607001 (1), 9230064 (1)



    Find genes that share compounds with MGST2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MGST2 gene (4 alternative transcripts): 
    NM_001204366.1  NM_001204367.1  NM_001204368.1  NM_002413.4  

    Unigene Cluster for MGST2:

    Microsomal glutathione S-transferase 2
    Hs.81874  [show with all ESTs]
    Unigene Representative Sequence: BX538128
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000265498(uc003ihy.3 uc021xse.1) ENST00000506797 ENST00000515137(uc021xsf.1 uc010ioi.1)
    ENST00000502587 ENST00000503816 ENST00000515067
    miRNA
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    hsa-miR-3688-3p hsa-miR-1271 hsa-miR-491-3p hsa-miR-103a hsa-miR-3142 hsa-miR-885-3p hsa-miR-182 hsa-miR-617
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    GenScript: all cDNA clones in your preferred vector (see all 4): MGST2 (NM_001204367)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MGST2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MGST2
    Primer
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    OriGene qPCR primer pairs and template standards for MGST2
    OriGene qSTAR qPCR primer pairs in human, mouse for MGST2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MGST2
      QuantiTect SYBR Green Assays in human, mouse, rat MGST2
      QuantiFast Probe-based Assays in human, mouse, rat MGST2

    Additional mRNA sequence: 

    AK130948.1 AK307231.1 BC025416.1 BX538128.1 CR407640.1 U77604.1 

    8 DOTS entries:

    DT.453234  DT.92431846  DT.92431849  DT.100815111  DT.121236341  DT.100740204  DT.121236331  DT.97820548 

    Selected AceView cDNA sequences (see all 178):

    BE791999 BG621659 BE909913 BM838445 BM856400 F30810 BI063204 BI062563 
    BI063000 BI062653 CB991077 CA942823 W93999 BI063059 AA122237 CR407640 
    AA452952 W93965 AU133068 BG109770 AI028327 W73826 AW958007 CD385200 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MGST2 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d
    SP1:                                                  -                                             
    SP2:                                -                 -     -                                       
    SP3:                                                  -     -     -                                 
    SP4:                                -                 -     -     -                                 
    SP5:                                -     -     -     -     -                                       


    ECgene alternative splicing isoforms for MGST2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    MGST2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGGTAATAT
    MGST2 Expression
    About this image


    MGST2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 16) fully expand
     
     Gonad
             XY Germ Cells Testis Cord
     
     Cartilage (Muscoskeletal System)
             Mesenchymal Condensate Cells Zeugopod
     
     Testis (Reproductive System)
             XY Germ Cells Testis Cord
     
     Primitive Streak (Early Embryonic Tissues)
             Primitive streak-like cells
     
     Bone (Muscoskeletal System)
             Mesenchymal Condensate Cells Zeugopod
    MGST2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MGST2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.81874

    UniProtKB/Swiss-Prot: MGST2_HUMAN, Q99735
    Tissue specificity: Liver, spleen, skeletal muscle, heart, adrenals, pancreas, prostate, testis, fetal liver, and
    fetal spleen. Very low expression in lung, brain, placenta and bone marrow

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MGST2: 
              Drug Metabolism: Phase II Enzymes in human mouse rat
              Drug Metabolism in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for MGST2
    OriGene qSTAR qPCR primer pairs in human, mouse for MGST2
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    QuantiFast Probe-based Assays in human, mouse, rat MGST2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MGST2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for MGST2 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mgst21 , 5 microsomal glutathione S-transferase 21, 5 80.27(n)1
    74.83(a)1
      3 (22.52 cM)5
    2116661  NM_174995.21  NP_778160.21 
     516603605 
    chicken
    (Gallus gallus)
    Aves MGST21 microsomal glutathione S-transferase 2 67.35(n)
    63.95(a)
      770916  XM_001234229.3  XP_001234230.1 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1017311461 microsomal glutathione S-transferase 2-like 59.54(n)
    59.31(a)
      101731146  XM_004911122.1  XP_004911179.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mgst21 microsomal glutathione S-transferase 2 56.15(n)
    53.08(a)
      723997  NM_001045302.2  NP_001038767.1 


    ENSEMBL Gene Tree for MGST2 (if available)
    TreeFam Gene Tree for MGST2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MGST2 gene
    LTC4S2  ALOX5AP2  
    3 SIMAP similar genes for MGST2 using alignment to 1 protein entry:     MGST2_HUMAN:
    LTC4S    MGST3    ALOX5AP

    Find genes that share paralogs with MGST2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MGST2 (see all 1507)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs81919971,2
    C,F,H--136313877(+) TTCCTG/ATATAT 4 -- us2k127Minor allele frequency- A:0.24NS EA NA WA CSA 2982
    rs81919981,2
    C,F,H--136313935(+) GTTCCC/TTCATG 4 -- us2k1 tfbs310Minor allele frequency- T:0.15NS EA WA CSA NA 947
    rs81919991,2
    C,F--136314336(+) cccctC/Ttgcaa 4 -- us2k12Minor allele frequency- T:0.04NS WA 288
    rs81920001,2
    C,F--136314352(+) atgttG/Aagacc 4 -- us2k12Minor allele frequency- A:0.02NS NA 174
    rs1855220351,2
    --136314458(+) TAAGAA/CGTGAC 4 -- us2k10--------
    rs81920011,2
    C,F--136314547(+) gattgG/Tccagc 4 -- us2k12Minor allele frequency- T:0.01NS WA 298
    rs81920021,2
    C,F,H--136314596(+) gaataA/Cattgc 4 -- us2k1 tfbs321Minor allele frequency- C:0.19NS EA NA WA CSA 2519
    rs1389026421,2
    --136314791(+) GGAACA/GACCTT 4 -- us2k10--------
    rs7956001,2
    C,F--136314793(-) ccaagG/Atcgtt 4 -- us2k19Minor allele frequency- A:0.35NA NS WA CSA EA 537
    rs1494224101,2
    C--136314847(+) CTCAGC/TCCCCT 4 -- us2k10--------

    HapMap Linkage Disequilibrium report for MGST2 (140586922 - 140661899 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for MGST2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv880162CNV Loss21882294
    nsv525242CNV Loss19592680
    dgv5766n71CNV Loss21882294
    nsv830086CNV Gain17160897

    Human Gene Mutation Database (HGMD): MGST2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MGST2
    DNA2.0 Custom Variant and Variant Library Synthesis for MGST2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601733    OMIM disorders: --


    Find genes that share disorders with MGST2           About GenesLikeMe

    2 Novoseek inferred disease relationships for MGST2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    psoriasis 40.2 9 16773312 (4), 16498398 (3)
    asthma 16 1 10436863 (1)

    Genetic Association Database (GAD): MGST2
    Human Genome Epidemiology (HuGE) Navigator: MGST2 (5 documents)

    Export disorders for MGST2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MGST2 gene, integrated from 10 sources (see all 27):
    (articles sorted by number of sources associating them with MGST2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of a novel human microsomal glutathione S-transferase with leukotriene C4 synthase activity and significant sequence identity to 5-lipoxygenase-activating protein and leukotriene C4 synthase. (PubMed id 8703034)1, 2, 3 Jakobsson P.-J.... Ford-Hutchinson A.W. (J. Biol. Chem. 1996)
    2. Systematic evaluation of association between the microsomal glutathione S-transferase 2 common variation and psoriasis vulgaris in Chinese population. (PubMed id 16773312)1, 4, 9 Yang S....Liu J.J. (Arch. Dermatol. Res. 2006)
    3. A novel MGST2 non-synonymous mutation in a Chinese pedigree with psoriasis vulgaris. (PubMed id 16498398)1, 4, 9 Yan K.L....Liu J.J. (J. Invest. Dermatol. 2006)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PubMed id 19343046)1, 4 Saito A....Kamatani N. (J. Hum. Genet. 2009)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Human umbilical vein endothelial cells generate leukotriene C4 via microsomal glutathione S-transferase type 2 and express the CysLT(1) receptor. (PubMed id 11322876)1, 9 SjAPstrAPm M....HaeggstrAPm J.Z. (Eur. J. Biochem. 2001)
    8. Catalytic characterization of human microsomal glutathione S-transferase 2: identification of rate-limiting steps. (PubMed id 23409838)1 Ahmad S....Rinaldo-Matthis A. (Biochemistry 2013)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    10. Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness. (PubMed id 17903302)4 Levy D....Mitchell G.F. (BMC Med. Genet. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4258 HGNC: 7063 AceView: MGST2 Ensembl:ENSG00000085871 euGenes: HUgn4258
    ECgene: MGST2 Kegg: 4258 H-InvDB: MGST2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MGST2 Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/mgst2/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MGST2 gene:
    Search GeneIP for patents involving MGST2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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