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MGST1 Gene

protein-coding   GIFtS: 66
GCID: GC12P016500

Microsomal Glutathione S-Transferase 1


(Previous symbol: GST12)
  See MGST1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Microsomal Glutathione S-Transferase 11 2     MGST2 3
GST121 2 3 5     EC 2.5.1.183 8
Microsomal GST-12 3     MGST-I2
Microsomal GST-I2 3     Glutathione S-Transferase 122

External Ids:    HGNC: 70611   Entrez Gene: 42572   Ensembl: ENSG000000083947   OMIM: 1383305   UniProtKB: P106203   

Export aliases for MGST1 gene to outside databases

Previous GC identifers: GC12P016240 GC12P016644 GC12P016400 GC12P016391


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MGST1 Gene:
The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human
proteins, two of which are involved in the production of leukotrienes and prostaglandin E, important mediators of
inflammation. Other family members, demonstrating glutathione S-transferase and peroxidase activities, are
involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds.
This gene encodes a protein that catalyzes the conjugation of glutathione to electrophiles and the reduction of
lipid hydroperoxides. This protein is localized to the endoplasmic reticulum and outer mitochondrial membrane
where it is thought to protect these membranes from oxidative stress. Several transcript variants, some
non-protein coding and some protein coding, have been found for this gene. (provided by RefSeq, May 2012)

GeneCards Summary for MGST1 Gene:
MGST1 (microsomal glutathione S-transferase 1) is a protein-coding gene. Diseases associated with MGST1 include megalencephalic leukoencephalopathy with subcortical cysts, and hereditary pancreatitis. GO annotations related to this gene include glutathione peroxidase activity and protein homodimerization activity. An important paralog of this gene is PTGES.

UniProtKB/Swiss-Prot: MGST1_HUMAN, P10620
Function: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic
electrophiles. Has a wide substrate specificity

Gene Wiki entry for MGST1 (Microsomal glutathione S-transferase 1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NT_009714.18  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MGST1 gene promoter:
         HFH-3   FOXI1   POU2F1   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): MGST1 promoter sequence
   Search Chromatin IP Primers for MGST1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MGST1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p12.3-p12.1   Ensembl cytogenetic band:  12p12.3   HGNC cytogenetic band: 12p12.3-p12.1

MGST1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MGST1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P016500:  view genomic region     (about GC identifiers)

Start:
16,500,076 bp from pter      End:
16,762,193 bp from pter
Size:
262,118 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: MGST1_HUMAN, P10620 (See protein sequence)
Recommended Name: Microsomal glutathione S-transferase 1  
Size: 155 amino acids; 17599 Da
Subunit: Homotrimer; The trimer binds only one molecule of glutathione (By similarity)
Secondary accessions: A8K533 G5EA53
Alternative splicing: 2 isoforms:  P10620-1   P10620-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MGST1: NX_P10620

Explore proteomics data for MGST1 at MOPED

Post-translational modifications: 

  • Peroxynitrite induces nitration at Tyr-93 which activates the enzyme (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • 3 DME Specific Peptides for MGST1 (P10620)
     KVFANPEDC  PFLGIGLLYSLSGPD  ARIYHTIAYLTPLPQPNR 


    See MGST1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (7 alternative transcripts): 
    NP_001247440.1  NP_001247441.1  NP_001254527.1  NP_064696.1  NP_665707.1  NP_665734.1  NP_665735.1  

    ENSEMBL proteins: 
     ENSP00000442557   ENSP00000442767   ENSP00000379513   ENSP00000438308   ENSP00000437988  
     ENSP00000442970   ENSP00000440443   ENSP00000379510   ENSP00000010404   ENSP00000379512  
    Reactome Protein details: P10620

    MGST1 Human Recombinant Protein Products:

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    Novus Biologicals MGST1 Protein
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MGST1

     
    Search eBioscience for Proteins for MGST1 

     
    antibodies-online proteins for MGST1 (3 products) 

     
    antibodies-online peptides for MGST1

    MGST1 Antibody Products:

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    antibodies-online kits for MGST1 (18 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    MGST: Glutathione S-transferases / Microsomal

    2 InterPro protein domains:
     IPR023352 MAPEG-like_dom
     IPR001129 Membr-assoc_MAPEG

    Graphical View of Domain Structure for InterPro Entry P10620

    ProtoNet protein and cluster: P10620

    1 Blocks protein domain: IPB001129 Membrane-associated proteins in eicosanoid and glutathione metabolism (MAPEG)

    UniProtKB/Swiss-Prot: MGST1_HUMAN, P10620
    Similarity: Belongs to the MAPEG family


    Find genes that share domains with MGST1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MGST1_HUMAN, P10620
    Function: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic
    electrophiles. Has a wide substrate specificity
    Catalytic activity: RX + glutathione = HX + R-S-glutathione
    Enzyme regulation: Can be activated by reagents that attack Cys-50 sulfhydryl, such as N-ethylmaleimide.
    Activation also occurs via nitration of Tyr-93 by peroxynitrite (By similarity)

         Genatlas biochemistry entry for MGST1:
    microsomal glutathione-S-transferase 1,microsomal,GST superfamily,expressed in the liver and several other tissues

         Enzyme Number (IUBMB): EC 2.5.1.181 2

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004364glutathione transferase activity IDA--
    GO:0004602glutathione peroxidase activity IDA--
    GO:0005515protein binding IPI--
    GO:0042802identical protein binding ----
    GO:0042803protein homodimerization activity IEA--
         
    Find genes that share ontologies with MGST1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for MGST1:
     Decreased nuclei size in G2M 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for MGST1

    miRNA
    Products:
        
    miRTarBase miRNAs that target MGST1:
    hsa-mir-96-5p (MIRT027876), hsa-mir-652-3p (MIRT039484)

    Block miRNA regulation of human, mouse, rat MGST1 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate MGST1
    SwitchGear 3'UTR luciferase reporter plasmidMGST1 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat MGST1

    Gene Editing
    Products:
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 4): MGST1 (NM_020300)
    Sino Biological Human cDNA Clone for MGST1
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MGST1

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MGST1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MGST1_HUMAN, P10620: Microsome (By similarity). Mitochondrion outer membrane; Peripheral membrane protein (By
    similarity). Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    mitochondrion5
    peroxisome4
    cytosol2
    nucleus2
    extracellular1

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005739mitochondrion IDA--
    GO:0005741mitochondrial outer membrane IEA--
    GO:0005743mitochondrial inner membrane IEA--
    GO:0005778peroxisomal membrane ISS--

    Find genes that share ontologies with MGST1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MGST1 About    
    See pathways by source

    SuperPathContained pathways About
    1Glutathione metabolism
    Glutathione metabolism0.65
    Glutathione conjugation0.60
    Glutathione metabolism0.65
    glutathione-mediated detoxification I0.42
    2Biological oxidations
    Biological oxidations0.56
    metapathway biotransformation0.42
    Phase II conjugation0.56
    3Chemical carcinogenesis
    Chemical carcinogenesis0.71
    Drug metabolism - cytochrome P4500.69
    Metabolism of xenobiotics by cytochrome P4500.71
    4Metabolism
    Metabolism0.38
    5Oxidative Stress
    Oxidative Stress


    Find genes that share SuperPaths with MGST1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for MGST1
        Glutathione metabolism

    3 BioSystems Pathways for MGST1
        Oxidative Stress
    glutathione-mediated detoxification I
    metapathway biotransformation


    1 Reactome Pathway for MGST1
        Glutathione conjugation


    4 Kegg Pathways  (Kegg details for MGST1):
        Glutathione metabolism
    Metabolism of xenobiotics by cytochrome P450
    Drug metabolism - cytochrome P450
    Chemical carcinogenesis

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MGST1: 
              Drug Metabolism: Phase II Enzymes in human mouse rat
              Drug Metabolism in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for MGST1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MGST1 (P106201, 3 ENSP000000104044) via UniProtKB, MINT, STRING, and/or I2D (see all 63)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NELFBQ8WX921, 3EBI-2691601,EBI-347721 I2D: score=1 
    LTC4SQ168733, ENSP000002925964I2D: score=1 STRING: ENSP00000292596
    ADH1AENSP000002096684STRING: ENSP00000209668
    ADH1BENSP000003066064STRING: ENSP00000306606
    ADH7ENSP000002096654STRING: ENSP00000209665
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006749glutathione metabolic process IEA--
    GO:0006805xenobiotic metabolic process TAS--
    GO:0010243response to organonitrogen compound IEA--
    GO:0032496response to lipopolysaccharide IEA--
    GO:0033327Leydig cell differentiation IEA--

    Find genes that share ontologies with MGST1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MGST1

    Selected HMDB Compounds for MGST1 (see all 12)    About this table
    CompoundSynonyms CAS #PubMed Ids
    2-Hydroxyestrone-1-S-glutathione2,3-dihydroxy-1,3,5[10]-estratriene-17-one-1-S-glutathione;2-hydroxyestrone-1-S-glutathione ----
    2-Hydroxyestrone-4-S-glutathione2,3-dihydroxy-1,3,5[10]-estratriene-17-one-4-S-glutathione ----
    4-Hydroxyestrone-2-S-glutathione3,4-dihydroxy-1,3,5[10]-estratriene-17-one-2-S-glutathione ----
    Adrenochromeadrenochrome oxidised;adrenochrome O-quinone;N-methyl-5,6-dioxo-2,3,5,6-tetrahydro-3-hydroxyindole;N-methyl-5,6-dioxo-2,3,5,6-tetrahydro-3-indolol;AdChr 54-06-8--
    Estrone-2,3-quinonecatecholestrogen quinone 40551-33-5--
    Estrone-3,4-quinonecatecholestrogen quinone 633-34-1--
    Glutathione5-L-Glutamyl-L-cysteinylglycine (see all 32)70-18-8--
    Hydrochloric acidHydrogen chloride anhydrous [UN1050] [Poison gas] (see all 16)7647-01-0--
    Noradrenochromenoradrenochrome O-quinone;noradrenochrome oxidised;5,6-dioxo-2,3,5,6-tetrahydro-3-hydroxyindole;5,6-dioxo-2,3,5,6-tetrahydro-3-indolol;AdChr 490-89-1--
    S-(PGJ2)-glutathioneGSPGJ2;9-(S-glutathionyl)-prostaglandin J(,2) ----

    1 DrugBank Compound for MGST1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Glutathione5-L-Glutamyl-L-cysteinylglycine (see all 5)70-18-8target--17306223 17297922

    Selected Novoseek inferred chemical compound relationships for MGST1 gene (see all 14)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gsts 78 3 15607001 (1), 9230064 (1), 17982697 (1)
    1-chloro-24-dinitrobenzene 68.1 2 9177297 (1), 15236595 (1)
    n-ethylmaleimide 62.5 3 15013818 (1), 15236595 (1)
    ltc4 54.9 3 11322876 (2), 9230064 (1)
    chlorambucil 42.2 1 16920737 (1)
    epoxide 41.6 1 11048672 (1)
    cysteine 21.2 5 14527828 (1), 17645877 (1), 9177297 (1), 15366924 (1)
    nadph 16.7 4 15013818 (3), 19428324 (1)
    estrogen 7.07 1 17982697 (1)
    tyrosine 0 2 10673221 (1), 12532421 (1)



    Find genes that share compounds with MGST1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MGST1 gene (7 alternative transcripts): 
    NM_001260511.1  NM_001260512.1  NM_001267598.1  NM_020300.4  NM_145764.2  NM_145791.2  NM_145792.2  

    Unigene Cluster for MGST1:

    Microsomal glutathione S-transferase 1
    Hs.389700  [show with all ESTs]
    Unigene Representative Sequence: AK123482
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000536371 ENST00000534835 ENST00000543076 ENST00000396210(uc001rdg.3)
    ENST00000539036 ENST00000537878 ENST00000542256(uc009zih.1) ENST00000539708
    ENST00000535309 ENST00000540056 ENST00000540126 ENST00000538885 ENST00000396207(uc001rdi.3)
    ENST00000538857 ENST00000535624 ENST00000359720 ENST00000010404(uc001rdf.3)
    ENST00000396209(uc001rdh.3)
    miRNA
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    GenScript: all cDNA clones in your preferred vector (see all 4): MGST1 (NM_020300)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MGST1
    Primer
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    OriGene qPCR primer pairs and template standards for MGST1
    OriGene qSTAR qPCR primer pairs in human, mouse for MGST1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MGST1
      QuantiTect SYBR Green Assays in human, mouse, rat MGST1
      QuantiFast Probe-based Assays in human, mouse, rat MGST1

    Additional mRNA sequence: 

    AK123482.1 AK291148.1 AK309707.1 BC005923.1 BC056863.1 BC062473.1 BT006982.1 CR407629.1 
    J03746.1 NR_048545.1 NR_048547.1 

    21 DOTS entries:

    DT.99937813  DT.100888209  DT.40255485  DT.91768506  DT.100888213  DT.100031556  DT.100888207  DT.121188419 
    DT.91995994  DT.121188368  DT.309711  DT.91768505  DT.101985177  DT.100693190  DT.121188425  DT.92025874 
    DT.121188361  DT.91833202  DT.91985767  DT.121188372  DT.91914092 

    Selected AceView cDNA sequences (see all 653):

    BM762189 NM_145791 BM840050 AA418533 H53334 BM784708 CR609242 AW069054 
    CB117478 CB116771 CA305959 CB268257 CB143860 AI167365 CB528319 CD368596 
    BE003775 BM760523 N90387 BE047685 AV649518 AA120994 BX282571 BG569399 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MGST1 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c · 6d
    SP1:              -     -                 -                                 
    SP2:                                      -                                 
    SP3:                                -     -                                 
    SP4:              -     -                 -     -                           
    SP5:                                                                        


    ECgene alternative splicing isoforms for MGST1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    MGST1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAATAAAGAA
    MGST1 Expression
    About this image


    MGST1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 23) fully expand
     
     Brain (Nervous System)    fully expand to see all 8 entries
             Cerebral Cortex
             N2/LSB/S/F8/CHIR-induced cells
     
     Neural Tube (Nervous System)    fully expand to see all 6 entries
             Metencephalon
             Floor plate-like cells
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Testicular Interstitial Cells Testis Interstitium
             Vas Deferens
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             Mesenchymal Condensate Cells Zeugopod
             Bone Marrow
     
     Liver (Hepatobiliary System)    fully expand to see all 2 entries
             Hepatocytes Liver Lobule
             Liver Lobule
    MGST1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MGST1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.389700

    UniProtKB/Swiss-Prot: MGST1_HUMAN, P10620
    Tissue specificity: Highly expressed in liver

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MGST1: 
              Drug Metabolism: Phase II Enzymes in human mouse rat
              Drug Metabolism in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MGST1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mgst11 , 5 microsomal glutathione S-transferase 11, 5 79.35(n)1
    82.58(a)1
      6 (68.40 cM)5
    566151  NM_019946.41  NP_064330.21 
     1381403165 
    chicken
    (Gallus gallus)
    Aves MGST11 microsomal glutathione S-transferase 1 72.47(n)
    67.74(a)
      418178  NM_001135550.1  NP_001129022.1 
    lizard
    (Anolis carolinensis)
    Reptilia MGST16
    microsomal glutathione S-transferase 1
    58(a)
    1 ↔ 1
    GL343336.1(659875-672966)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia mgst11 microsomal glutathione S-transferase 1 59.35(n)
    58.71(a)
      496690  NM_001011245.1  NP_001011245.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mgst1.11 microsomal glutathione S-transferase 1.1 57.36(n)
    57.14(a)
      449784  NM_001005957.1  NP_001005957.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Mgstl1 Microsomal glutathione S-transferase-like 51.54(n)
    48.23(a)
      44110  NM_079957.4  NP_524696.2 


    ENSEMBL Gene Tree for MGST1 (if available)
    TreeFam Gene Tree for MGST1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MGST1 gene
    PTGES2  
    1 SIMAP similar gene for MGST1 using alignment to 7 protein entries:     MGST1_HUMAN (see all proteins):
    PTGES

    Find genes that share paralogs with MGST1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MGST1 (see all 752)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs108463321,2
    C,F,A--16498097(+) GTTTTA/GAAAAC 1 -- us2k17Minor allele frequency- G:0.36WA NA EA 366
    rs1167235961,2
    F--16498154(+) TTCTAA/GTTTGA 1 -- us2k11Minor allele frequency- G:0.02WA 118
    rs1479440881,2
    --16498169(+) CTGAAC/TAGTCT 1 -- us2k10--------
    rs756456451,2
    C--16498176(+) TCTGC-/TTTTTT 1 -- us2k10--------
    rs1842866791,2
    --16498466(+) TGTCAA/GTTATT 1 -- us2k10--------
    rs1174505221,2
    F--16498481(+) AACTTT/CTACCT 1 -- us2k11Minor allele frequency- C:0.01NA 120
    rs1901089051,2
    --16498492(+) GTTACC/TGCCCT 1 -- us2k10--------
    rs124261251,2
    H--16498496(+) CCGCCC/GTAGTT 1 -- us2k14Minor allele frequency- G:0.00NS EA 418
    rs1418675701,2
    --16498543(+) CTTTCC/TTTCCA 1 -- us2k10--------
    rs1822136691,2
    --16498621(+) AGCTCC/TTTGAC 6 -- us2k10--------

    HapMap Linkage Disequilibrium report for MGST1 (16500076 - 16750076 bp, first 250kb of MGST1)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for MGST1:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv1381n71CNV Loss21882294
    nsv832338CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MGST1
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 138330    OMIM disorders: --

    2 diseases for MGST1:    
    About MalaCards
    megalencephalic leukoencephalopathy with subcortical cysts    hereditary pancreatitis


    Find genes that share disorders with MGST1           About GenesLikeMe

    4 Novoseek inferred disease relationships for MGST1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carcinoma squamous cell 0 1 12532421 (1)
    inflammation 0 2 18786635 (2)
    tumors 0 1 15645424 (1)
    cancer 0 1 18333132 (1)

    Genetic Association Database (GAD): MGST1
    Human Genome Epidemiology (HuGE) Navigator: MGST1 (6 documents)

    Export disorders for MGST1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MGST1 gene, integrated from 10 sources (see all 96):
    (articles sorted by number of sources associating them with MGST1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genetic analysis of the glutathione s-transferase genes MGST1, GSTM3, GSTT1, and GSTM1 in patients with hereditary pancreatitis. (PubMed id 15338373)1, 4, 9 Schneider A....Whitcomb D.C. (J. Gastroenterol. 2004)
    2. Structural organization of the human microsomal glutathione S- transferase gene (GST12). (PubMed id 8812420)1, 2, 9 Kelner M.J.... Montoya M.A. (Genomics 1996)
    3. Microsomal glutathione S-transferase gene polymorphisms and colorectal cancer risk in a Han Chinese population. (PubMed id 17483957)1, 4, 9 Zhang H....Wu M. (Int J Colorectal Dis 2007)
    4. Functional candidate genes in age-related macular degeneration: significant association with VEGF, VLDLR, and LRP6. (PubMed id 16384981)1, 4, 9 Haines J.L....Pericak-Vance M.A. (amp 2006)
    5. Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PubMed id 19343046)1, 4 Saito A....Kamatani N. (J. Hum. Genet. 2009)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Microsomal GST-I: genomic organization, expression, and alternative splicing of the human gene. (PubMed id 10524215)1, 2 Lee S.H. and DeJong J. (Biochim. Biophys. Acta 1999)
    8. Gene expression of rat and human microsomal glutathione S- transferases. (PubMed id 3372534)1, 2 Dejong J.L.... Tu C.-P.D. (J. Biol. Chem. 1988)
    9. Structural organization of the microsomal glutathione S-transferase gene (MGST1) on chromosome 12p13.1-13.2. Identification of the correct promoter region and demonstration of transcriptional regulation in response to oxidative stress. (PubMed id 10777602)1, 9 Kelner M.J....Morgenstern R. (J. Biol. Chem. 2000)
    10. Catalog of 46 single-nucleotide polymorphisms (SNPs) in the microsomal glutathione S-transferase 1 (MGST1) gene. (PubMed id 11587073)1, 9 Iida A....Nakamura Y. (J. Hum. Genet. 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4257 HGNC: 7061 AceView: MGST1 Ensembl:ENSG00000008394 euGenes: HUgn4257
    ECgene: MGST1 Kegg: 4257 H-InvDB: MGST1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MGST1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MGST1 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/mgst1/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MGST1 gene:
    Search GeneIP for patents involving MGST1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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