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Aliases for MGST1 Gene

Aliases for MGST1 Gene

  • Microsomal Glutathione S-Transferase 1 2 3 5
  • Microsomal GST-1 3 4
  • Microsomal GST-I 3 4
  • EC 2.5.1.18 4 58
  • GST12 3 4
  • MGST 3 4
  • Glutathione S-Transferase 12 3
  • MGST-I 3

External Ids for MGST1 Gene

Previous HGNC Symbols for MGST1 Gene

  • GST12

Previous GeneCards Identifiers for MGST1 Gene

  • GC12P016240
  • GC12P016644
  • GC12P016400
  • GC12P016391
  • GC12P016500

Summaries for MGST1 Gene

Entrez Gene Summary for MGST1 Gene

  • The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, two of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. Other family members, demonstrating glutathione S-transferase and peroxidase activities, are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. This gene encodes a protein that catalyzes the conjugation of glutathione to electrophiles and the reduction of lipid hydroperoxides. This protein is localized to the endoplasmic reticulum and outer mitochondrial membrane where it is thought to protect these membranes from oxidative stress. Several transcript variants, some non-protein coding and some protein coding, have been found for this gene. [provided by RefSeq, May 2012]

GeneCards Summary for MGST1 Gene

MGST1 (Microsomal Glutathione S-Transferase 1) is a Protein Coding gene. Diseases associated with MGST1 include Megalencephalic Leukoencephalopathy With Subcortical Cysts. Among its related pathways are Glutathione metabolism and Metabolism. GO annotations related to this gene include protein homodimerization activity and glutathione transferase activity. An important paralog of this gene is PTGES.

UniProtKB/Swiss-Prot for MGST1 Gene

  • Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has a wide substrate specificity.

Gene Wiki entry for MGST1 Gene

Additional gene information for MGST1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MGST1 Gene

Genomics for MGST1 Gene

Regulatory Elements for MGST1 Gene

Enhancers for MGST1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12H016346 1.3 ENCODE dbSUPER 24.2 +3.0 2969 6 FOXA2 ARNT ARID4B SIN3A DMAP1 YY1 GLIS2 FOS RUNX3 SP3 MGST1 SLC15A5 GC12P016380
GH12H016389 0.4 ENCODE 11 +42.6 42560 0 MAX GABPA MGST1 GC12P016380 SUPT16HP1
GH12H016280 0.6 ENCODE 5.7 -65.8 -65765 1 MAX REST RAD21 FOXA1 GABPA YY1 JUND ATF3 HNF4G HNF4A MGST1 SLC15A5 PIR41579
GH12H016367 0.2 dbSUPER 11.4 +21.9 21872 3 MGST1 ENSG00000256564 LMO3 GC12P016380
GH12H016299 0.4 ENCODE 4.9 -46.8 -46844 1 SCRT2 MGST1 PIR41579 SLC15A5
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MGST1 on UCSC Golden Path with GeneCards custom track

Promoters for MGST1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000049324 1258 2401 FOXA2 ARNT ARID4B SIN3A DMAP1 YY1 TCF12 GLIS2 FOS RUNX3

Genomic Location for MGST1 Gene

Chromosome:
12
Start:
16,347,142 bp from pter
End:
16,609,259 bp from pter
Size:
262,118 bases
Orientation:
Plus strand

Genomic View for MGST1 Gene

Genes around MGST1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MGST1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MGST1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MGST1 Gene

Proteins for MGST1 Gene

  • Protein details for MGST1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P10620-MGST1_HUMAN
    Recommended name:
    Microsomal glutathione S-transferase 1
    Protein Accession:
    P10620
    Secondary Accessions:
    • A8K533
    • G5EA53

    Protein attributes for MGST1 Gene

    Size:
    155 amino acids
    Molecular mass:
    17599 Da
    Quaternary structure:
    • Homotrimer; The trimer binds only one molecule of glutathione.

    Alternative splice isoforms for MGST1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MGST1 Gene

Selected DME Specific Peptides for MGST1 Gene

P10620:
  • KVFANPEDC
  • PFLGIGLLYSLSGPD
  • ARIYHTIAYLTPLPQPNR

Post-translational modifications for MGST1 Gene

  • Peroxynitrite induces nitration at Tyr-93 which activates the enzyme.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for MGST1 Gene

Gene Families for MGST1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for MGST1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P10620

UniProtKB/Swiss-Prot:

MGST1_HUMAN :
  • Belongs to the MAPEG family.
Family:
  • Belongs to the MAPEG family.
genes like me logo Genes that share domains with MGST1: view

Function for MGST1 Gene

Molecular function for MGST1 Gene

GENATLAS Biochemistry:
microsomal glutathione-S-transferase 1,microsomal,GST superfamily,expressed in the liver and several other tissues
UniProtKB/Swiss-Prot CatalyticActivity:
RX + glutathione = HX + R-S-glutathione.
UniProtKB/Swiss-Prot EnzymeRegulation:
Can be activated by reagents that attack Cys-50 sulfhydryl, such as N-ethylmaleimide. Activation also occurs via nitration of Tyr-93 by peroxynitrite (By similarity).
UniProtKB/Swiss-Prot Function:
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has a wide substrate specificity.

Enzyme Numbers (IUBMB) for MGST1 Gene

Phenotypes From GWAS Catalog for MGST1 Gene

Gene Ontology (GO) - Molecular Function for MGST1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004364 glutathione transferase activity TAS --
GO:0004602 glutathione peroxidase activity IDA 20727966
GO:0005515 protein binding IPI 20195357
GO:0016740 transferase activity IEA --
GO:0042802 identical protein binding IEA --
genes like me logo Genes that share ontologies with MGST1: view
genes like me logo Genes that share phenotypes with MGST1: view

Animal Model Products

CRISPR Products

miRNA for MGST1 Gene

miRTarBase miRNAs that target MGST1

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for MGST1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MGST1 Gene

Localization for MGST1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MGST1 Gene

Microsome. Mitochondrion outer membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MGST1 gene
Compartment Confidence
mitochondrion 5
endoplasmic reticulum 5
plasma membrane 4
peroxisome 4
lysosome 4
nucleus 3
cytosol 3
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (2)
  • Mitochondria (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MGST1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005739 mitochondrion IEA,IDA 20727966
GO:0005741 mitochondrial outer membrane IEA --
GO:0005778 peroxisomal membrane ISS --
GO:0005783 endoplasmic reticulum ISS --
genes like me logo Genes that share ontologies with MGST1: view

Pathways & Interactions for MGST1 Gene

genes like me logo Genes that share pathways with MGST1: view

Gene Ontology (GO) - Biological Process for MGST1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006805 xenobiotic metabolic process TAS --
GO:0010243 response to organonitrogen compound IEA --
GO:0032496 response to lipopolysaccharide IEA --
GO:0033327 Leydig cell differentiation IEA --
GO:0042493 response to drug IEA --
genes like me logo Genes that share ontologies with MGST1: view

No data available for SIGNOR curated interactions for MGST1 Gene

Drugs & Compounds for MGST1 Gene

(9) Drugs for MGST1 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glutathione Approved Nutra Target 0
Water Approved Pharma 0
Trichloroethylene Pharma 5

(46) Additional Compounds for MGST1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(1R)-Glutathionyl-(2R)-hydroxy-1,2-dihydronaphthalene
(1R)-Hydroxy-(2R)-glutathionyl-1,2-dihydronaphthalene
(1S)-Hydroxy-(2S)-glutathionyl-1,2-dihydronaphthalene
(1S,2R)-Naphthalene 1,2-oxide
1,1-Dichloroethylene epoxide
genes like me logo Genes that share compounds with MGST1: view

Transcripts for MGST1 Gene

Unigene Clusters for MGST1 Gene

Microsomal glutathione S-transferase 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for MGST1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MGST1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c · 6d
SP1: - - -
SP2: -
SP3: - -
SP4: - - - -
SP5:
SP6: - -

Relevant External Links for MGST1 Gene

GeneLoc Exon Structure for
MGST1
ECgene alternative splicing isoforms for
MGST1

Expression for MGST1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MGST1 Gene

mRNA differential expression in normal tissues according to GTEx for MGST1 Gene

This gene is overexpressed in Liver (x9.0), Adrenal Gland (x6.8), and Adipose - Visceral (Omentum) (x4.5).

Protein differential expression in normal tissues from HIPED for MGST1 Gene

This gene is overexpressed in Nasal epithelium (17.6) and Liver (12.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MGST1 Gene



Protein tissue co-expression partners for MGST1 Gene

NURSA nuclear receptor signaling pathways regulating expression of MGST1 Gene:

MGST1

SOURCE GeneReport for Unigene cluster for MGST1 Gene:

Hs.389700

mRNA Expression by UniProt/SwissProt for MGST1 Gene:

P10620-MGST1_HUMAN
Tissue specificity: Highly expressed in liver.

Evidence on tissue expression from TISSUES for MGST1 Gene

  • Liver(4.9)
  • Nervous system(4.6)
  • Lung(3.4)
  • Adrenal gland(3)
  • Kidney(3)
  • Heart(2.6)
  • Intestine(2.5)
  • Gall bladder(2.2)
  • Thyroid gland(2.2)
  • Muscle(2)
genes like me logo Genes that share expression patterns with MGST1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for MGST1 Gene

Orthologs for MGST1 Gene

This gene was present in the common ancestor of animals.

Orthologs for MGST1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MGST1 33 34
  • 99.57 (n)
dog
(Canis familiaris)
Mammalia MGST1 33 34
  • 88.6 (n)
cow
(Bos Taurus)
Mammalia MGST1 33 34
  • 87.31 (n)
mouse
(Mus musculus)
Mammalia Mgst1 33 16 34
  • 79.35 (n)
rat
(Rattus norvegicus)
Mammalia Mgst1 33
  • 77.85 (n)
oppossum
(Monodelphis domestica)
Mammalia MGST1 34
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves MGST1 33 34
  • 72.47 (n)
lizard
(Anolis carolinensis)
Reptilia MGST1 34
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mgst1 33
  • 59.35 (n)
zebrafish
(Danio rerio)
Actinopterygii mgst1.1 33 34
  • 57.36 (n)
mgst1.2 34
  • 57 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Mgstl 33 34
  • 51.54 (n)
CG33177 34
  • 36 (a)
ManyToMany
CG33178 34
  • 33 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta GSTMIC1 33
  • 49.07 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 50 (a)
OneToMany
-- 34
  • 44 (a)
OneToMany
-- 34
  • 38 (a)
OneToMany
-- 34
  • 33 (a)
OneToMany
Species where no ortholog for MGST1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MGST1 Gene

ENSEMBL:
Gene Tree for MGST1 (if available)
TreeFam:
Gene Tree for MGST1 (if available)

Paralogs for MGST1 Gene

Paralogs for MGST1 Gene

(1) SIMAP similar genes for MGST1 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with MGST1: view

Variants for MGST1 Gene

Sequence variations from dbSNP and Humsavar for MGST1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000018649 -- 16,359,891(+) ATTCC(G/T)CCCTA intron-variant
rs1000029810 -- 16,359,618(+) TAAAA(A/T)AAAGT intron-variant
rs1000294151 -- 16,366,009(+) CGTCT(C/T)TCATC intron-variant
rs1000337448 -- 16,372,411(+) GGCCA(A/G)CTAGT intron-variant
rs1000563723 -- 16,359,772(+) AACTG(A/G)AAAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MGST1 Gene

Variant ID Type Subtype PubMed ID
esv3892149 CNV loss 25118596
esv3892150 CNV loss 25118596
nsv1036638 CNV loss 25217958
nsv1049805 CNV loss 25217958
nsv832338 CNV gain 17160897

Variation tolerance for MGST1 Gene

Residual Variation Intolerance Score: 61.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.71; 15.09% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MGST1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MGST1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MGST1 Gene

Disorders for MGST1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MGST1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
megalencephalic leukoencephalopathy with subcortical cysts
  • vacuolating megalencephalic leukoencephalopathy with subcortical cysts
- elite association - COSMIC cancer census association via MalaCards
Search MGST1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MGST1

Genetic Association Database (GAD)
MGST1
Human Genome Epidemiology (HuGE) Navigator
MGST1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MGST1
genes like me logo Genes that share disorders with MGST1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MGST1 Gene

Publications for MGST1 Gene

  1. Microsomal glutathione S-transferase gene polymorphisms and colorectal cancer risk in a Han Chinese population. (PMID: 17483957) Zhang H … Wu M (International journal of colorectal disease 2007) 3 22 45 60
  2. Functional candidate genes in age-related macular degeneration: significant association with VEGF, VLDLR, and LRP6. (PMID: 16384981) Haines JL … Pericak-Vance MA (Investigative ophthalmology & visual science 2006) 3 22 45 60
  3. Genetic analysis of the glutathione s-transferase genes MGST1, GSTM3, GSTT1, and GSTM1 in patients with hereditary pancreatitis. (PMID: 15338373) Schneider A … Whitcomb DC (Journal of gastroenterology 2004) 3 22 45 60
  4. Structural organization of the human microsomal glutathione S-transferase gene (GST12). (PMID: 8812420) Kelner MJ … Montoya MA (Genomics 1996) 3 4 22 60
  5. Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PMID: 19343046) Saito A … Kamatani N (Journal of human genetics 2009) 3 45 60

Products for MGST1 Gene

Sources for MGST1 Gene

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