Aliases for MGST1 Gene
External Ids for MGST1 Gene
Previous HGNC Symbols for MGST1 Gene
Previous GeneCards Identifiers for MGST1 Gene
The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, two of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. Other family members, demonstrating glutathione S-transferase and peroxidase activities, are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. This gene encodes a protein that catalyzes the conjugation of glutathione to electrophiles and the reduction of lipid hydroperoxides. This protein is localized to the endoplasmic reticulum and outer mitochondrial membrane where it is thought to protect these membranes from oxidative stress. Several transcript variants, some non-protein coding and some protein coding, have been found for this gene. [provided by RefSeq, May 2012]
GeneCards Summary for MGST1 Gene
MGST1 (Microsomal Glutathione S-Transferase 1) is a Protein Coding gene. Diseases associated with MGST1 include Megalencephalic Leukoencephalopathy With Subcortical Cysts. Among its related pathways are Cytochrome P450 - arranged by substrate type and Drug metabolism - cytochrome P450. GO annotations related to this gene include protein homodimerization activity and glutathione transferase activity. An important paralog of this gene is PTGES.
UniProtKB/Swiss-Prot for MGST1 Gene
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has a wide substrate specificity.