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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

MGST1 Gene

protein-coding GIFtS: 66
GCID: GC12P016500

microsomal glutathione S-transferase 1

(Previous symbol: GST12)

Explore 22 diseases affiliated with
MGST1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Microsomal Glutathione S-Transferase 1¹ ²		Microsomal GST-I² ³
GST12¹ ² ³ ⁵		MGST² ³
MGST-I¹ ²		EC 2.5.1.18³ ⁸
Microsomal GST-1² ³		Glutathione S-Transferase 12²

External Ids:	HGNC: 7061¹	Entrez Gene: 4257²	Ensembl: ENSG00000008394⁷	OMIM: 138330⁵	UniProtKB: P10620³

Export aliases for MGST1 gene to outside databases

Previous GC identifers: GC12P016240 GC12P016644 GC12P016400 GC12P016391

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MGST1:

The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human

proteins, two of which are involved in the production of leukotrienes and prostaglandin E, important mediators of

inflammation. Other family members, demonstrating glutathione S-transferase and peroxidase activities, are involved in

cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. This gene encodes

a protein that catalyzes the conjugation of glutathione to electrophiles and the reduction of lipid hydroperoxides.

This protein is localized to the endoplasmic reticulum and outer mitochondrial membrane where it is thought to protect

these membranes from oxidative stress. Several transcript variants, some non-protein coding and some protein coding,

have been found for this gene. (provided by RefSeq, May 2012)

UniProtKB/Swiss-Prot: MGST1_HUMAN, P10620

Function: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

Has a wide substrate specificity

Gene Wiki entry for MGST1 (Microsomal glutathione S-transferase 1)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000012.11 NC_018923.1 NT_009714.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the MGST1 gene promoter:
HFH-3 FOXI1 POU2F1 POU2F1a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): MGST1 promoter sequence

Search SABiosciences Chromatin IP Primers for MGST1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MGST1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p12.3-p12.1 Ensembl cytogenetic band: 12p12.3 HGNC cytogenetic band: 12p12.3-p12.1

MGST1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MGST1 gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12P016500: view genomic region (about GC identifiers)

Start:	16,500,076 bp from pter	End:	16,762,193 bp from pter
Size:	262,118 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MGST1_HUMAN, P10620 (See protein sequence)

Recommended Name: Microsomal glutathione S-transferase 1

Size: 155 amino acids; 17599 Da

Subunit: Homotrimer; The trimer binds only one molecule of glutathione (By similarity)

Subcellular location: Microsome (By similarity). Mitochondrion outer membrane; Peripheral membrane protein (By

similarity). Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity)

Secondary accessions: A8K533 G5EA53

Alternative splicing: 2 isoforms: P10620-1 P10620-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MGST1: NX_P10620

Post-translational modifications:

Peroxynitrite induces nitration at Tyr-93 which activates the enzyme (By similarity)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P10620

3 DME Specific Peptides for MGST1 (P10620)

KVFANPEDC

PFLGIGLLYSLSGPD

ARIYHTIAYLTPLPQPNR

MGST1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (7 alternative transcripts):

NP_001247440.1 NP_001247441.1 NP_001254527.1 NP_064696.1 NP_665707.1 NP_665734.1 NP_665735.1

ENSEMBL proteins:

ENSP00000442557 ENSP00000442767 ENSP00000379513 ENSP00000438308 ENSP00000437988

ENSP00000442970 ENSP00000440443 ENSP00000379510 ENSP00000010404 ENSP00000379512

Reactome Protein details: P10620
Human Recombinant Protein Products:

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	Uscn Proteins for MGST1

Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005739	mitochondrion	IDA	--
GO:0005741	mitochondrial outer membrane	IEA	--
GO:0005743	mitochondrial inner membrane	IEA	--
GO:0005778	peroxisomal membrane	ISS	--

MGST1 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for MGST1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

MGST1 for domains About GeneDecksing

2 InterPro domains/families:

IPR023352 MAPEG-like_dom

IPR001129 Membr-assoc_MAPEG

Graphical View of Domain Structure for InterPro Entry P10620

ProtoNet protein and cluster: P10620

1 Blocks protein family: IPB001129 Membrane-associated proteins in eicosanoid and glutathione metabolism (MAPEG)

UniProtKB/Swiss-Prot: MGST1_HUMAN, P10620

Similarity: Belongs to the MAPEG family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: MGST1_HUMAN, P10620

Function: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

Has a wide substrate specificity

Catalytic activity: RX + glutathione = HX + R-S-glutathione

Enzyme regulation: Can be activated by reagents that attack Cys-50 sulfhydryl, such as N-ethylmaleimide. Activation

also occurs via nitration of Tyr-93 by peroxynitrite (By similarity)

Genatlas biochemistry entry for MGST1:

microsomal glutathione-S-transferase 1,microsomal,GST superfamily,expressed in the liver and several other tissues

Enzyme Number (IUBMB): EC 2.5.1.18¹ ²

miRNA Products:		OriGene 3'-UTR Clone (see all 4): MGST1 Browse MicroRNA Expression Plasmids
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Gene Editing
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MGST1

Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004364	glutathione transferase activity	IDA	--
GO:0004602	glutathione peroxidase activity	IDA	--
GO:0005515	protein binding	IPI	--
GO:0016740	transferase activity	--	--
GO:0042802	identical protein binding	--	--

MGST1 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for MGST1:

Decreased nuclei size in G2M

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Glutathione metabolism

Glutathione metabolism	1.00	glutathione-mediated detoxification I	0.53
Glutathione metabolism	0.92	Glutathione conjugation	0.50
Glutathione metabolism	0.70

Biological oxidations

	Biological oxidations	1.00			metapathway biotransformation	0.41
	Phase II conjugation	0.52

Drug metabolism - cytochrome P450

Drug metabolism - cytochrome P450

1.00

Metabolism of xenobiotics by cytochrome P450

0.73

Metabolism

Metabolism

1.00

Oxidative Stress

Oxidative Stress

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for MGST1

Glutathione metabolism

1 GeneGo (Thomson Reuters) Pathway for MGST1

Glutathione metabolism

3 BioSystems Pathways for MGST1

	glutathione-mediated detoxification I
	metapathway biotransformation
	Oxidative Stress

4 Reactome Pathways for MGST1

	Metabolism
	Biological oxidations
	Glutathione conjugation
	Phase II conjugation

3 Kegg Pathways (Kegg details for MGST1):

	Glutathione metabolism
	Metabolism of xenobiotics by cytochrome P450
	Drug metabolism - cytochrome P450

MGST1 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for MGST1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/64 Interacting proteins for MGST1 (P10620^{1, 3} ENSP00000010404⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 64)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
COBRA1	Q8WX92¹^,³	EBI-2691601,EBI-347721 I2D: score=1
NELFB	Q8WX92¹^,³	EBI-2691601,EBI-347721 I2D: score=1
LTC4S	Q16873³, ENSP00000292596⁴	I2D: score=1 STRING: ENSP00000292596
ADH7	ENSP00000209665⁴	STRING: ENSP00000209665
CYP1A1	ENSP00000369050⁴	STRING: ENSP00000369050

About this table

Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006749	glutathione metabolic process	IEA	--
GO:0006805	xenobiotic metabolic process	TAS	--
GO:0010243	response to organic nitrogen	IEA	--
GO:0032496	response to lipopolysaccharide	IEA	--
GO:0033327	Leydig cell differentiation	IEA	--

MGST1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

MGST1 for compounds About GeneDecksing

EMD Millipore small molecules for MGST1:
Small Molecule - inhibitor

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for MGST1

10/12 HMDB Compounds for MGST1 (see all 12) About this table

Compound	Synonyms	CAS #	PubMed Ids
2-Hydroxyestrone-1-S-glutathione	2,3-dihydroxy-1,3,5[10]-estratriene-17-one-1-S-glutathione;2-hydroxyestrone-1-S-glutathione	--	--
2-Hydroxyestrone-4-S-glutathione	2,3-dihydroxy-1,3,5[10]-estratriene-17-one-4-S-glutathione	--	--
4-Hydroxyestrone-2-S-glutathione	3,4-dihydroxy-1,3,5[10]-estratriene-17-one-2-S-glutathione	--	--
Adrenochrome	adrenochrome oxidised;adrenochrome O-quinone;N-methyl-5,6-dioxo-2,3,5,6-tetrahydro-3-hydroxyindole;N-methyl-5,6-dioxo-2,3,5,6-tetrahydro-3-indolol;AdChr	54-06-8	--
Estrone-2,3-quinone	catecholestrogen quinone	40551-33-5	--
Estrone-3,4-quinone	catecholestrogen quinone	633-34-1	--
Glutathione	5-L-Glutamyl-L-cysteinylglycine (see all 32)	70-18-8	--
Hydrochloric acid	Hydrogen chloride anhydrous [UN1050] [Poison gas] (see all 16)	7647-01-0	--
Noradrenochrome	noradrenochrome O-quinone;noradrenochrome oxidised;5,6-dioxo-2,3,5,6-tetrahydro-3-hydroxyindole;5,6-dioxo-2,3,5,6-tetrahydro-3-indolol;AdChr	490-89-1	--
S-(PGJ2)-glutathione	GSPGJ2;9-(S-glutathionyl)-prostaglandin J(,2)	--	--

1 DrugBank Compound for MGST1 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Glutathione	5-L-Glutamyl-L-cysteinylglycine (see all 5)	70-18-8	target	--	17306223 17297922

10/14 Novoseek chemical compound relationships for MGST1 gene (see all 14) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
gsts	78	3	15607001 (1), 9230064 (1), 17982697 (1)
1-chloro-24-dinitrobenzene	68.1	2	9177297 (1), 15236595 (1)
n-ethylmaleimide	62.5	3	15013818 (1), 15236595 (1)
ltc4	54.9	3	11322876 (2), 9230064 (1)
chlorambucil	42.2	1	16920737 (1)
epoxide	41.6	1	11048672 (1)
cysteine	21.2	5	14527828 (1), 17645877 (1), 9177297 (1), 15366924 (1)
nadph	16.7	4	15013818 (3), 19428324 (1)
estrogen	7.07	1	17982697 (1)
tyrosine	0	2	10673221 (1), 12532421 (1)

Search CenterWatch for drugs/clinical trials and news about MGST1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MGST1 gene (7 alternative transcripts):

NM_001260511.1 NM_001260512.1 NM_001267598.1 NM_020300.4 NM_145764.2 NM_145791.2 NM_145792.2

Unigene Cluster for MGST1:

Microsomal glutathione S-transferase 1

Hs.389700 [show with all ESTs]

Unigene Representative Sequence: AK123482

18/19 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):

ENST00000536371 ENST00000534835 ENST00000543076 ENST00000396210(uc001rdg.3)

ENST00000539036 ENST00000537878 ENST00000542256(uc009zih.1) ENST00000539708

ENST00000535309 ENST00000540056 ENST00000540126 ENST00000538885 ENST00000396207(uc001rdi.3)

ENST00000538857 ENST00000535624 ENST00000395815 ENST00000359720 ENST00000010404(uc001rdf.3)

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Additional cDNA sequence:

AK123482.1 AK291148.1 AK309707.1 BC005923.1 BC056863.1 BC062473.1 BT006982.1 CR407629.1

J03746.1 NR_048545.1 NR_048547.1

21 DOTS entries:

DT.99937813 DT.100888209 DT.40255485 DT.91768506 DT.100888213 DT.100031556 DT.100888207 DT.121188419

DT.91995994 DT.121188368 DT.309711 DT.91768505 DT.101985177 DT.100693190 DT.121188425 DT.92025874

DT.121188361 DT.91833202 DT.91985767 DT.121188372 DT.91914092

24/653 AceView cDNA sequences (see all 653):

AW148701 AU128622 BU688561 BQ000282 BM993042 AV656557 BM981349 CA444712

CA435976 NM_145791 CB116771 BQ436421 CD368596 BQ676238 AA120994 BQ717643

CB143860 CB528319 NM_145792 BM840050 AU126584 BE003712 R01853 BU683344

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for MGST1 (see all 6) About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4a	·	4b	·	4c	^	5	^	6a	·	6b	·	6c	·	6d
SP1:					-		-						-
SP2:													-
SP3:											-		-
SP4:					-		-						-		-
SP5:

ECgene alternative splicing isoforms for MGST1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MGST1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAATAAAGAA

About this image

MGST1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

10/15 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 15)

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Gut Tube

Hindgut

Hindgut Endoderm Cells

Endoderm

Gut Tube

Midgut

Midgut Endoderm Cells

Endoderm

Limb

Zeugopod

Mesenchymal Condensate Cells

Bone, Cartilage

Limb

Zeugopod

Prechondrocytic Mesenchymal Cells

Bone, Cartilage

Brain

Brain

Gut Tube

Gut Tube

Liver

Lung

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 3 LifeMap Cells

Name

Category

Sclerotome cells (Primary Cell)

Bone, Cartilage, Somite

N2/LSB/S/F8/CHIR-induced cells (Generation of midbra...)

Ventral/hypothalamic-like neurons (Generation of midbra...)

See MGST1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MGST1

SOURCE GeneReport for Unigene cluster: Hs.389700

UniProtKB/Swiss-Prot: MGST1_HUMAN, P10620

Tissue specificity: Highly expressed in liver

SABiosciences Expression via Pathway-Focused PCR Arrays including MGST1:

Drug Metabolism: Phase II Enzymes in human mouse rat

Drug Metabolism in human mouse rat

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MGST1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MGST1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for MGST1 gene from 5/18 species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Mgst1^{1 , 5}	microsomal glutathione S-transferase 1^{1, 5}	79.35(n)¹ 82.58(a)¹		6 (68.40 cM)⁵ 56615¹ NM_019946.4¹ NP_064330.2¹ 138140316⁵
chicken (Gallus gallus)	Aves	MGST1¹	microsomal glutathione S-transferase 1	72.47(n) 67.74(a)		418178 NM_001135550.1 NP_001129022.1
lizard (Anolis carolinensis)	Reptilia	MGST1⁶	--	59(a)	1 ↔ 1	GL343336.1(662535-665313)
zebrafish (Danio rerio)	Actinopterygii	mgst1¹	microsomal glutathione S-transferase 1	57.36(n) 57.14(a)		449784 NM_001005957.1 NP_001005957.1
fruit fly (Drosophila melanogaster)	Insecta	Mgstl¹	Microsomal glutathione S-transferase-like	51.77(n) 48.23(a)		44110 NM_079957.3 NP_524696.2

ENSEMBL Gene Tree for MGST1 (if available)
TreeFam Gene Tree for MGST1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for MGST1 gene

PTGES²

1 SIMAP similar gene for MGST1 using alignment to 7 protein entries: MGST1_HUMAN (see all proteins):

PTGES

MGST1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs10846332^1,2	C,F,A,	--	16498097(+)	`GTTTTA/GAAAAC`	1	--	us2k¹		7		WA NA EA	366
rs116723596^1,2	F,	--	16498154(+)	`TTCTAA/GTTTGA`	1	--	us2k¹		1		WA	118
rs147944088^1,2		--	16498169(+)	`CTGAAC/TAGTCT`	1	--	us2k¹		0	--	--	--	--
rs75645645^1,2	C,	--	16498176(+)	`TCTGC-/TTTTTT`	1	--	us2k¹		0	--	--	--	--
rs184286679^1,2		--	16498466(+)	`TGTCAA/GTTATT`	1	--	us2k¹		0	--	--	--	--
rs117450522^1,2		--	16498481(+)	`AACTTT/CTACCT`	1	--	us2k¹		1		NA	120
rs190108905^1,2		--	16498492(+)	`GTTACC/TGCCCT`	1	--	us2k¹		0	--	--	--	--
rs12426125^1,2	H	--	16498496(+)	`CCGCCC/GTAGTT`	1	--	us2k¹		4		NS EA	418
rs141867570^1,2		--	16498543(+)	`CTTTCC/TTTCCA`	1	--	us2k¹		0	--	--	--	--
rs182213669^1,2		--	16498621(+)	`AGCTCC/TTTGAC`	6	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for MGST1 (16500076 - 16750076 bp, first 250kb of MGST1)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MGST1: --

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QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MGST1

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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MGST1 for disorders           About GeneDecksing

OMIM gene information: 138330    OMIM disorders: --

20/22 diseases for MGST1 (see all 22):    About MalaCards

megalencephalic leukoencephalopathy with subcortical cysts age related macular degeneration diabetic macular edema macular degeneration

primary biliary cirrhosis exfoliation syndrome bronchogenic carcinoma basal cell carcinoma

hereditary pancreatitis laryngitis laryngeal carcinoma parkinson's disease

cataract pancreatitis endometriosis carcinoma

pancreatic cancer colorectal cancer breast cancer sarcoma

4 Novoseek disease relationships for MGST1 gene About this table

Disease	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
carcinoma squamous cell	1	12532421 (1)
inflammation	2	18786635 (2)
tumors	1	15645424 (1)
cancer	1	18333132 (1)

Genetic Association Database (GAD): MGST1
Human Genome Epidemiology (HuGE) Navigator: MGST1 (6 documents)

Export disorders for MGST1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for MGST1 gene, integrated from 9 sources (see all 92):
(articles sorted by number of sources associating them with MGST1)

Utopia: connect your pdf to the dynamic
world of online information

Genetic analysis of the glutathione s-transferase genes MGST1, GSTM3, GSTT1, and GSTM1 in patients with hereditary pancreatitis. (PubMed id 15338373)^{1, 4, 9} Schneider A....Whitcomb D.C. (2004)
Structural organization of the human microsomal glutathione S- transferase gene (GST12). (PubMed id 8812420)^{1, 2, 9} Kelner M.J.... Montoya M.A. (1996)
Functional candidate genes in age-related macular degeneration: significant association with VEGF, VLDLR, and LRP6. (PubMed id 16384981)^{1, 4, 9} Haines J.L....Pericak-Vance M.A. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Microsomal GST-I: genomic organization, expression, and alternative splicing of the human gene. (PubMed id 10524215)^{1, 2} Lee S.H. and DeJong J. (1999)
Gene expression of rat and human microsomal glutathione S- transferases. (PubMed id 3372534)^{1, 2} Dejong J.L.... Tu C.-P.D. (1988)
Structural organization of the microsomal glutathione S-transferase gene (MGST1) on chromosome 12p13.1-13.2. Identification of the correct promoter region and demonstration of transcriptional regulation in response to oxidative stress. (PubMed id 10777602)^{1, 9} Kelner M.J....Morgenstern R. (2000)
Catalog of 46 single-nucleotide polymorphisms (SNPs) in the microsomal glutathione S-transferase 1 (MGST1) gene. (PubMed id 11587073)^{1, 9} Iida A....Nakamura Y. (2001)
Protection of cells from oxidative stress by microsomal glutathione transferase 1. (PubMed id 17306223)^{7, 9} Siritantikorn A....Morgenstern R. (2007)
Age-related transcription levels of KU70, MGST1 and B IK in CD34+ hematopoietic stem and progenitor cells. (PubMed id 17714764)^{1, 9} Prall W.C....Aivado M. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 4257	HGNC: 7061	AceView: MGST1	Ensembl:ENSG00000008394	euGenes: HUgn4257
ECgene: MGST1	Kegg: 4257	H-InvDB: MGST1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for MGST1	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for MGST1	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/mgst1/

Intellectual Property for MGST1 gene
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Patent Information for MGST1 gene:
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GeneCards and IP:
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microsomal glutathione S-transferase 1

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MGST1 Gene

microsomal glutathione S-transferase 1

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