Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MGST1 Gene

protein-coding   GIFtS: 66
GCID: GC12P016500

Microsomal Glutathione S-Transferase 1


(Previous symbol: GST12)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Microsomal Glutathione S-Transferase 11 2     MGST2 3
GST121 2 3 5     EC 2.5.1.183 8
Microsomal GST-12 3     MGST-I2
Microsomal GST-I2 3     Glutathione S-Transferase 122

External Ids:    HGNC: 70611   Entrez Gene: 42572   Ensembl: ENSG000000083947   OMIM: 1383305   UniProtKB: P106203   

Export aliases for MGST1 gene to outside databases

Previous GC identifers: GC12P016240 GC12P016644 GC12P016400 GC12P016391


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MGST1 Gene:
The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human
proteins, two of which are involved in the production of leukotrienes and prostaglandin E, important mediators of
inflammation. Other family members, demonstrating glutathione S-transferase and peroxidase activities, are
involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds.
This gene encodes a protein that catalyzes the conjugation of glutathione to electrophiles and the reduction of
lipid hydroperoxides. This protein is localized to the endoplasmic reticulum and outer mitochondrial membrane
where it is thought to protect these membranes from oxidative stress. Several transcript variants, some
non-protein coding and some protein coding, have been found for this gene. (provided by RefSeq, May 2012)

GeneCards Summary for MGST1 Gene: 
MGST1 (microsomal glutathione S-transferase 1) is a protein-coding gene. Diseases associated with MGST1 include megalencephalic leukoencephalopathy with subcortical cysts, and bronchogenic carcinoma, and among its related super-pathways are Glutathione metabolism and Phase II conjugation. GO annotations related to this gene include glutathione peroxidase activity and protein homodimerization activity. An important paralog of this gene is PTGES.

UniProtKB/Swiss-Prot: MGST1_HUMAN, P10620
Function: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic
electrophiles. Has a wide substrate specificity

Gene Wiki entry for MGST1 (Microsomal glutathione S-transferase 1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.2  NT_009714.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MGST1 gene promoter:
         HFH-3   FOXI1   POU2F1   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): MGST1 promoter sequence
   Search SABiosciences Chromatin IP Primers for MGST1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MGST1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p12.3-p12.1   Ensembl cytogenetic band:  12p12.3   HGNC cytogenetic band: 12p12.3-p12.1

MGST1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MGST1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P016500:  view genomic region     (about GC identifiers)

Start:
16,500,076 bp from pter      End:
16,762,193 bp from pter
Size:
262,118 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MGST1_HUMAN, P10620 (See protein sequence)
Recommended Name: Microsomal glutathione S-transferase 1  
Size: 155 amino acids; 17599 Da
Subunit: Homotrimer; The trimer binds only one molecule of glutathione (By similarity)
Subcellular location: Microsome (By similarity). Mitochondrion outer membrane; Peripheral membrane protein (By
similarity). Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity)
Secondary accessions: A8K533 G5EA53
Alternative splicing: 2 isoforms:  P10620-1   P10620-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MGST1: NX_P10620

Explore proteomics data for MGST1 at MOPED 

Post-translational modifications:

  • UniProtKB: Peroxynitrite induces nitration at Tyr-93 which activates the enzyme (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P10620

  • 3 DME Specific Peptides for MGST1 (P10620)
     KVFANPEDC  PFLGIGLLYSLSGPD  ARIYHTIAYLTPLPQPNR 

    MGST1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MGST1 Protein Expression
    REFSEQ proteins (7 alternative transcripts): 
    NP_001247440.1  NP_001247441.1  NP_001254527.1  NP_064696.1  NP_665707.1  NP_665734.1  NP_665735.1  

    ENSEMBL proteins: 
     ENSP00000442557   ENSP00000442767   ENSP00000379513   ENSP00000438308   ENSP00000437988  
     ENSP00000442970   ENSP00000440443   ENSP00000379510   ENSP00000010404   ENSP00000379512  
    Reactome Protein details: P10620
    Human Recombinant Protein Products for MGST1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for MGST1
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for MGST1
    GenScript Custom Purified and Recombinant Proteins Services for MGST1
    Novus Biologicals MGST1 Protein
    Novus Biologicals MGST1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MGST1 

    Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005739mitochondrion IDA--
    GO:0005741mitochondrial outer membrane IEA--
    GO:0005743mitochondrial inner membrane IEA--
    GO:0005778peroxisomal membrane ISS--

    MGST1 for ontologies           About GeneDecksing



    MGST1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for MGST1
    OriGene Custom Antibody Services for MGST1
    GenScript Custom Superior Antibodies Services for MGST1
    Novus Biologicals MGST1 Antibodies
    Abcam antibodies for MGST1
    Cloud-Clone Corp. Antibodies for MGST1 
    ThermoFisher Antibodies for MGST1
    LSBio Antibodies in human, mouse, rat for MGST1 

    Assay Products for MGST1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MGST1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MGST1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MGST1 
    Cloud-Clone Corp. CLIAs for MGST1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    MGST: Glutathione S-transferases / Microsomal

    2 InterPro protein domains:
     IPR023352 MAPEG-like_dom
     IPR001129 Membr-assoc_MAPEG

    Graphical View of Domain Structure for InterPro Entry P10620

    ProtoNet protein and cluster: P10620

    1 Blocks protein domain: IPB001129 Membrane-associated proteins in eicosanoid and glutathione metabolism (MAPEG)

    UniProtKB/Swiss-Prot: MGST1_HUMAN, P10620
    Similarity: Belongs to the MAPEG family


    MGST1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MGST1_HUMAN, P10620
    Function: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic
    electrophiles. Has a wide substrate specificity
    Catalytic activity: RX + glutathione = HX + R-S-glutathione
    Enzyme regulation: Can be activated by reagents that attack Cys-50 sulfhydryl, such as N-ethylmaleimide.
    Activation also occurs via nitration of Tyr-93 by peroxynitrite (By similarity)

         Genatlas biochemistry entry for MGST1:
    microsomal glutathione-S-transferase 1,microsomal,GST superfamily,expressed in the liver and several other tissues

         Enzyme Number (IUBMB): EC 2.5.1.181 2

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004364glutathione transferase activity IDA--
    GO:0004602glutathione peroxidase activity IDA--
    GO:0005515protein binding IPI--
    GO:0042802identical protein binding ----
    GO:0042803protein homodimerization activity IEA--
         
    MGST1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for MGST1:
     Decreased nuclei size in G2M 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for MGST1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MGST1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MGST1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MGST1 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MGST1
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate MGST1
    SwitchGear 3'UTR luciferase reporter plasmidMGST1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MGST1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MGST1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MGST1
    Sirion Biotech Customized adenovirus for overexpression of MGST1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for MGST1 (see all 19)
    OriGene ORF clones in mouse, rat for MGST1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): MGST1 (NM_020300)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MGST1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MGST1
    Sirion Biotech Customized lentivirus for stable overexpression of MGST1 
                         Customized lentivirus expression plasmids for stable overexpression of MGST1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MGST1
    Search LifeMap BioReagents cell lines for MGST1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MGST1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MGST1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Glutathione metabolism
    Glutathione metabolism0.92
    Glutathione conjugation0.60
    Glutathione metabolism0.67
    glutathione-mediated detoxification I0.42
    2Biological oxidations
    Biological oxidations0.55
    metapathway biotransformation0.41
    Phase II conjugation0.55
    3Drug metabolism - cytochrome P450
    Metabolism of xenobiotics by cytochrome P4500.77
    Drug metabolism - cytochrome P4500.73
    Chemical carcinogenesis0.77
    4Metabolism
    Metabolism0.40
    5Oxidative Stress
    Oxidative Stress

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for MGST1
        Glutathione metabolism


    1 GeneGo (Thomson Reuters) Pathway for MGST1
        Glutathione metabolism

    3 BioSystems Pathways for MGST1
        Oxidative Stress
    glutathione-mediated detoxification I
    metapathway biotransformation

    4        Reactome Pathways for MGST1
        Metabolism
    Biological oxidations
    Glutathione conjugation
    Phase II conjugation


    4         Kegg Pathways  (Kegg details for MGST1):
        Glutathione metabolism
    Metabolism of xenobiotics by cytochrome P450
    Drug metabolism - cytochrome P450
    Chemical carcinogenesis


    MGST1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MGST1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/63 Interacting proteins for MGST1 (P106201, 3 ENSP000000104044) via UniProtKB, MINT, STRING, and/or I2D (see all 63)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NELFBQ8WX921, 3EBI-2691601,EBI-347721 I2D: score=1 
    LTC4SQ168733, ENSP000002925964I2D: score=1 STRING: ENSP00000292596
    ADH7ENSP000002096654STRING: ENSP00000209665
    CYP1A1ENSP000003690504STRING: ENSP00000369050
    CYP1A2ENSP000003420074STRING: ENSP00000342007
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006749glutathione metabolic process IEA--
    GO:0006805xenobiotic metabolic process TAS--
    GO:0010243response to organonitrogen compound IEA--
    GO:0032496response to lipopolysaccharide IEA--
    GO:0033327Leydig cell differentiation IEA--

    MGST1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MGST1 for compounds           About GeneDecksing

    EMD Millipore small molecules for MGST1:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MGST1

    10/12 HMDB Compounds for MGST1 (see all 12)    About this table
    CompoundSynonyms CAS #PubMed Ids
    2-Hydroxyestrone-1-S-glutathione2,3-dihydroxy-1,3,5[10]-estratriene-17-one-1-S-glutathione;2-hydroxyestrone-1-S-glutathione ----
    2-Hydroxyestrone-4-S-glutathione2,3-dihydroxy-1,3,5[10]-estratriene-17-one-4-S-glutathione ----
    4-Hydroxyestrone-2-S-glutathione3,4-dihydroxy-1,3,5[10]-estratriene-17-one-2-S-glutathione ----
    Adrenochromeadrenochrome oxidised;adrenochrome O-quinone;N-methyl-5,6-dioxo-2,3,5,6-tetrahydro-3-hydroxyindole;N-methyl-5,6-dioxo-2,3,5,6-tetrahydro-3-indolol;AdChr 54-06-8--
    Estrone-2,3-quinonecatecholestrogen quinone 40551-33-5--
    Estrone-3,4-quinonecatecholestrogen quinone 633-34-1--
    Glutathione5-L-Glutamyl-L-cysteinylglycine (see all 32)70-18-8--
    Hydrochloric acidHydrogen chloride anhydrous [UN1050] [Poison gas] (see all 16)7647-01-0--
    Noradrenochromenoradrenochrome O-quinone;noradrenochrome oxidised;5,6-dioxo-2,3,5,6-tetrahydro-3-hydroxyindole;5,6-dioxo-2,3,5,6-tetrahydro-3-indolol;AdChr 490-89-1--
    S-(PGJ2)-glutathioneGSPGJ2;9-(S-glutathionyl)-prostaglandin J(,2) ----

    1 DrugBank Compound for MGST1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Glutathione5-L-Glutamyl-L-cysteinylglycine (see all 5)70-18-8target--17306223 17297922

    10/14 Novoseek inferred chemical compound relationships for MGST1 gene (see all 14)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gsts 78 3 15607001 (1), 9230064 (1), 17982697 (1)
    1-chloro-24-dinitrobenzene 68.1 2 9177297 (1), 15236595 (1)
    n-ethylmaleimide 62.5 3 15013818 (1), 15236595 (1)
    ltc4 54.9 3 11322876 (2), 9230064 (1)
    chlorambucil 42.2 1 16920737 (1)
    epoxide 41.6 1 11048672 (1)
    cysteine 21.2 5 14527828 (1), 17645877 (1), 9177297 (1), 15366924 (1)
    nadph 16.7 4 15013818 (3), 19428324 (1)
    estrogen 7.07 1 17982697 (1)
    tyrosine 0 2 10673221 (1), 12532421 (1)

    Search CenterWatch for drugs/clinical trials and news about MGST1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MGST1 gene (7 alternative transcripts): 
    NM_001260511.1  NM_001260512.1  NM_001267598.1  NM_020300.4  NM_145764.2  NM_145791.2  NM_145792.2  

    Unigene Cluster for MGST1:

    Microsomal glutathione S-transferase 1
    Hs.389700  [show with all ESTs]
    Unigene Representative Sequence: AK123482
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000536371 ENST00000534835 ENST00000543076 ENST00000396210(uc001rdg.3)
    ENST00000539036 ENST00000537878 ENST00000542256(uc009zih.1) ENST00000539708
    ENST00000535309 ENST00000540056 ENST00000540126 ENST00000538885 ENST00000396207(uc001rdi.3)
    ENST00000538857 ENST00000535624 ENST00000359720 ENST00000010404(uc001rdf.3)
    ENST00000396209(uc001rdh.3)

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MGST1
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate MGST1
    SwitchGear 3'UTR luciferase reporter plasmidMGST1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MGST1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MGST1
    Clone
    Products:
         
    OriGene clones in human, mouse for MGST1 (see all 19)
    OriGene ORF clones in mouse, rat for MGST1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): MGST1 (NM_020300)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MGST1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MGST1
    Sirion Biotech Customized lentivirus for stable overexpression of MGST1 
                         Customized lentivirus expression plasmids for stable overexpression of MGST1 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for MGST1
    OriGene qSTAR qPCR primer pairs in human, mouse for MGST1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MGST1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MGST1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MGST1

    Additional mRNA sequence: 

    AK123482.1 AK291148.1 AK309707.1 BC005923.1 BC056863.1 BC062473.1 BT006982.1 CR407629.1 
    J03746.1 NR_048545.1 NR_048547.1 

    21 DOTS entries:

    DT.99937813  DT.100888209  DT.40255485  DT.91768506  DT.100888213  DT.100031556  DT.100888207  DT.121188419 
    DT.91995994  DT.121188368  DT.309711  DT.91768505  DT.101985177  DT.100693190  DT.121188425  DT.92025874 
    DT.121188361  DT.91833202  DT.91985767  DT.121188372  DT.91914092 

    24/653 AceView cDNA sequences (see all 653):

    BG569399 NM_145792 AI167365 R01853 BQ717643 BU683344 CF126900 BC062473 
    BX282571 CB143860 CB528319 BE047685 AV656557 AW802617 NM_020300 CD368596 
    CB268257 N90387 AV649518 BE003775 BM760523 BM981349 BU688767 AU128622 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for MGST1 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c · 6d
    SP1:              -     -                 -                                 
    SP2:                                      -                                 
    SP3:                                -     -                                 
    SP4:              -     -                 -     -                           
    SP5:                                                                        


    ECgene alternative splicing isoforms for MGST1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MGST1 expression in normal human tissues (normalized intensities)      MGST1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAATAAAGAA
    MGST1 Expression
    About this image


    MGST1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/37 selected tissues (see all 37) fully expand
     
     Brain (Nervous System)    fully expand to see all 9 entries
             Thalamus
             N2/LSB/S/F8/CHIR-induced cells ( Generation of midbrain dopaminergic, forebrain and...
             brain/midbrain   
     
     Neural Tube (Nervous System)    fully expand to see all 6 entries
             Metencephalon
             spinal cord/lateral wall/ventricular layer   
     
     Lower Urinary Tract (Urinary System)    fully expand to see all 6 entries
             urinary bladder ; urothelial cells   
             visceral organ   
     
     Testis (Reproductive System)    fully expand to see all 5 entries
             Testicular Interstitial Cells Testis Interstitium
             Vas Deferens
             testis ; cells in seminiferus ducts   
     
     Nose (Sensory Organs)    fully expand to see all 5 entries
             nasopharynx ; respiratory epithelial cells   
             sensory organ/nose/nasal cavity   

    See MGST1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MGST1

    SOURCE GeneReport for Unigene cluster: Hs.389700

    UniProtKB/Swiss-Prot: MGST1_HUMAN, P10620
    Tissue specificity: Highly expressed in liver

        SABiosciences Expression via Pathway-Focused PCR Arrays including MGST1: 
              Drug Metabolism: Phase II Enzymes in human mouse rat
              Drug Metabolism in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for MGST1
    OriGene qSTAR qPCR primer pairs in human, mouse for MGST1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MGST1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MGST1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MGST1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MGST1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for MGST1 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mgst11 , 5 microsomal glutathione S-transferase 11, 5 79.35(n)1
    82.58(a)1
      6 (68.40 cM)5
    566151  NM_019946.41  NP_064330.21 
     1381403165 
    chicken
    (Gallus gallus)
    Aves MGST11 microsomal glutathione S-transferase 1 72.47(n)
    67.74(a)
      418178  NM_001135550.1  NP_001129022.1 
    lizard
    (Anolis carolinensis)
    Reptilia MGST16
    Uncharacterized protein
    58(a)
    1 ↔ 1
    GL343336.1(659875-672966)
    zebrafish
    (Danio rerio)
    Actinopterygii mgst11 microsomal glutathione S-transferase 1 57.36(n)
    57.14(a)
      449784  NM_001005957.1  NP_001005957.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Mgstl1 Microsomal glutathione S-transferase-like 51.77(n)
    48.23(a)
      44110  NM_079957.3  NP_524696.2 


    ENSEMBL Gene Tree for MGST1 (if available)
    TreeFam Gene Tree for MGST1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MGST1 gene
    PTGES2  
    1 SIMAP similar gene for MGST1 using alignment to 7 protein entries:     MGST1_HUMAN (see all proteins):
    PTGES

    MGST1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/752 SNPs in MGST1 are shown (see all 752)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs108463321,2
    C,F,A--16498097(+) GTTTTA/GAAAAC 1 -- us2k17Minor allele frequency- G:0.36WA NA EA 366
    rs1167235961,2
    F--16498154(+) TTCTAA/GTTTGA 1 -- us2k11Minor allele frequency- G:0.02WA 118
    rs1479440881,2
    --16498169(+) CTGAAC/TAGTCT 1 -- us2k10--------
    rs756456451,2
    C--16498176(+) TCTGC-/TTTTTT 1 -- us2k10--------
    rs1842866791,2
    --16498466(+) TGTCAA/GTTATT 1 -- us2k10--------
    rs1174505221,2
    F--16498481(+) AACTTT/CTACCT 1 -- us2k11Minor allele frequency- C:0.01NA 120
    rs1901089051,2
    --16498492(+) GTTACC/TGCCCT 1 -- us2k10--------
    rs124261251,2
    H--16498496(+) CCGCCC/GTAGTT 1 -- us2k14Minor allele frequency- G:0.00NS EA 418
    rs1418675701,2
    --16498543(+) CTTTCC/TTTCCA 1 -- us2k10--------
    rs1822136691,2
    --16498621(+) AGCTCC/TTTGAC 6 -- us2k10--------

    HapMap Linkage Disequilibrium report for MGST1 (16500076 - 16750076 bp, first 250kb of MGST1)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for MGST1:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv1381n71CNV Loss21882294
    nsv832338CNV Gain17160897

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing MGST1
    DNA2.0 Custom Variant and Variant Library Synthesis for MGST1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 138330    OMIM disorders: --

    20/23 diseases for MGST1 (see all 23):    About MalaCards
    megalencephalic leukoencephalopathy with subcortical cysts    bronchogenic carcinoma    exfoliation syndrome    diabetic macular edema
    hereditary pancreatitis    laryngeal carcinoma    age related macular degeneration    primary biliary cirrhosis
    macular degeneration    basal cell carcinoma    laryngitis    cataract
    cytochrome p450    endometriosis    parkinson's disease    pancreatitis
    pancreatic cancer    sarcoma    colorectal cancer    hepatocellular carcinoma


    MGST1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    4 Novoseek inferred disease relationships for MGST1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carcinoma squamous cell 0 1 12532421 (1)
    inflammation 0 2 18786635 (2)
    tumors 0 1 15645424 (1)
    cancer 0 1 18333132 (1)

    Genetic Association Database (GAD): MGST1
    Human Genome Epidemiology (HuGE) Navigator: MGST1 (6 documents)

    Export disorders for MGST1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MGST1 gene, integrated from 9 sources (see all 96):
    (articles sorted by number of sources associating them with MGST1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genetic analysis of the glutathione s-transferase genes MGST1, GSTM3, GSTT1, and GSTM1 in patients with hereditary pancreatitis. (PubMed id 15338373)1, 4, 9 Schneider A....Whitcomb D.C. (2004)
    2. Structural organization of the human microsomal glutathione S- transferase gene (GST12). (PubMed id 8812420)1, 2, 9 Kelner M.J.... Montoya M.A. (1996)
    3. Microsomal glutathione S-transferase gene polymorphisms and colorectal cancer risk in a Han Chinese population. (PubMed id 17483957)1, 4, 9 Zhang H....Wu M. (2007)
    4. Functional candidate genes in age-related macular degeneration: significant association with VEGF, VLDLR, and LRP6. (PubMed id 16384981)1, 4, 9 Haines J.L....Pericak-Vance M.A. (2006)
    5. Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PubMed id 19343046)1, 4 Saito A....Kamatani N. (2009)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Microsomal GST-I: genomic organization, expression, and alternative splicing of the human gene. (PubMed id 10524215)1, 2 Lee S.H. and DeJong J. (1999)
    8. Gene expression of rat and human microsomal glutathione S- transferases. (PubMed id 3372534)1, 2 Dejong J.L.... Tu C.-P.D. (1988)
    9. Structural organization of the microsomal glutathione S-transferase gene (MGST1) on chromosome 12p13.1-13.2. Identification of the correct promoter region and demonstration of transcriptional regulation in response to oxidative stress. (PubMed id 10777602)1, 9 Kelner M.J....Morgenstern R. (2000)
    10. Catalog of 46 single-nucleotide polymorphisms (SNPs) in the microsomal glutathione S-transferase 1 (MGST1) gene. (PubMed id 11587073)1, 9 Iida A....Nakamura Y. (2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4257 HGNC: 7061 AceView: MGST1 Ensembl:ENSG00000008394 euGenes: HUgn4257
    ECgene: MGST1 Kegg: 4257 H-InvDB: MGST1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MGST1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MGST1 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/mgst1/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MGST1 gene:
    Search GeneIP for patents involving MGST1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
     EMD Millipore small molecules (inhibitor) for MGST1
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for MGST1   OriGene RNAi products in human, mouse, rat for MGST1  
     OriGene qPCR primer pairs and template standards for MGST1   OriGene Protein Over-expression Lysate for MGST1  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for MGST1  
     OriGene qSTAR qPCR primer pairs in human, mouse for MGST1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for MGST1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for MGST1   OriGene Custom Protein Services for MGST1  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MGST1
     QIAGEN SeqTarget long-range PCR primers for resequencing MGST1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MGST1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MGST1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MGST1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MGST1
     GenScript Custom Purified and Recombinant Proteins Services for MGST1 GenScript cDNA clones with any tag delivered in your preferred vector for MGST1
     GenScript Custom Assay Services for MGST1 GenScript Custom Superior Antibodies Services for MGST1
     GenScript Custom overexpressing Cell Line Services for MGST1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in MGST1 promoter
     Search Chromatin IP Primers for MGST1
     RT2 qPCR Primer Assay in human, mouse, rat MGST1
     Search GNC Networks for MGST1
     SABiosciences PCR Arrays including human, mouse, rat MGST1
     Search Tocris compounds for MGST1
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     MGST1 antibodies
     MGST1 proteins
     MGST1 lysates
     Antibodies for MGST1
     See all of Abcam's Antibodies, Kits and Proteins for MGST1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for MGST1
     Antibodies for MGST1
     ELISAs for MGST1
     CLIAs for MGST1
     Search LifeMap BioReagents cell lines for MGST1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MGST1
     SwitchGear 3'UTR luciferase reporter plasmids for MGST1
     SwitchGear Promoter luciferase reporter plasmids for MGST1
     ThermoFisher Antibodies for MGST1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MGST1
     inGenious Targeting Laboratory - Custom generated mouse model solutions for MGST1
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MGST1
    Customized:
     lentivirus for stable overexpression of MGST1
     lentivirus expression plasmids for stable overexpression of MGST1
     adenovirus for overexpression of MGST1
     LSBio Antibodies in human, mouse, rat for MGST1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      MGST1 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4